RU96113203A - BICYCLIC AROMATIC COMPOUNDS AS THERAPEUTIC MEDICINES - Google Patents

BICYCLIC AROMATIC COMPOUNDS AS THERAPEUTIC MEDICINES

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Publication number
RU96113203A
RU96113203A RU96113203/04A RU96113203A RU96113203A RU 96113203 A RU96113203 A RU 96113203A RU 96113203/04 A RU96113203/04 A RU 96113203/04A RU 96113203 A RU96113203 A RU 96113203A RU 96113203 A RU96113203 A RU 96113203A
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RU
Russia
Prior art keywords
benzodioxan
ylmethyl
methylamine
piperid
methoxyphenyl
Prior art date
Application number
RU96113203/04A
Other languages
Russian (ru)
Other versions
RU2136680C1 (en
Inventor
Керриган Франк
Джон Хил Дэвид
Франк Мартин Кит
Original Assignee
Кноль Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939318431A external-priority patent/GB9318431D0/en
Application filed by Кноль Аг filed Critical Кноль Аг
Publication of RU96113203A publication Critical patent/RU96113203A/en
Application granted granted Critical
Publication of RU2136680C1 publication Critical patent/RU2136680C1/en

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Claims (7)

1. Производные амина общей формулы I
Figure 00000001

где R - галоид, гидроксил, алкил с 1 - 3 атомами углерода, алкоксил с 1 - 3 атомами углерода;
Q - двухвалентная группа общей формулы IIа
Figure 00000002

или общей формулы IIб
Figure 00000003

где V - метилен или этилен;
Х - алкиленовая цепь с 0 - 2 атомами углерода;
Х' - алкиленовая цепь с 1 - 4 атомами углерода;
при этом общее число атомов углерода в остатках Х и Х' составляет 3 или 4;
Т - фенил, пиридил, пиразинил, бензо[b]фуранил, 1,4-бензодиоксанил и хиназолинил, незамещенные или замещенные галоидом, метоксилом или трифторметилом;
m = 0, 1,
и их фармацевтически приемлемые соли.1. Amine derivatives of the general formula I
Figure 00000001

where R is halogen, hydroxyl, alkyl with 1 to 3 carbon atoms, alkoxyl with 1 to 3 carbon atoms;
Q is a divalent group of the general formula IIa
Figure 00000002

or general formula IIb
Figure 00000003

where V is methylene or ethylene;
X is an alkylene chain with 0 to 2 carbon atoms;
X 'is an alkylene chain with 1 to 4 carbon atoms;
wherein the total number of carbon atoms in residues X and X ′ is 3 or 4;
T is phenyl, pyridyl, pyrazinyl, benzo [b] furanyl, 1,4-benzodioxanyl and quinazolinyl, unsubstituted or substituted by halogen, methoxy or trifluoromethyl;
m = 0, 1,
and their pharmaceutically acceptable salts. 2. Производные амина формулы I по п.1, где R - гидроксил, метокси, фтор или хлор. 2. Derivatives of the amine of formula I according to claim 1, where R is hydroxyl, methoxy, fluorine or chlorine. 3. Производные амина формулы I по п.1, где Т - 2-пиридил, 2-пиразинил, фенил, 2,3-дигидробензо[b] фуран-7-ил, 1,4-бензодиоксан-5-ил или 4-хиназолинил, незамещенные или замещенные метоксилом, трифторметилом или галоидом. 3. The amine derivatives of formula I according to claim 1, where T is 2-pyridyl, 2-pyrazinyl, phenyl, 2,3-dihydrobenzo [b] furan-7-yl, 1,4-benzodioxan-5-yl or 4- quinazolinyl unsubstituted or substituted with methoxyl, trifluoromethyl or halogen. 4. Производные амина формулы I по п.1, выбранные из группы, включающей
Figure 00000004
-(1,4-бензодиоксан-2-илметил)-1-[1-(пиразин-2-ил)пиперид-4-ил]метиламин;
Figure 00000005
- (1,4-бензодиоксан-2-илметил)-1-[1-(2-метоксифенил)пиперид-4-ил] метиламин;
Figure 00000006
-(1,4-бензодиоксан-2-илметил)-1-[1-(3-хлорпирид-2-ил)пиперид-4-] -метиламин;
Figure 00000007
-(1,4-бензодиоксан-2-илметил)-1-[1-(хиназолин-4-ил)пиперид-4-ил]метиламин;
Figure 00000008
-(1,4-бензодиоксан-2-илметил)-1-[1-(пиперид-4-ил] метиламин;
Figure 00000009
-(8-метокси-1,4-бензодиоксан-2-илметил)-1-[1-(2-метоксифенил)пиперид-4-ил] метиламин;
Figure 00000010
-(1,4-бензодиоксан-2-илметил)-1-(1-фенилпиперид-4-ил)метиламин;
Figure 00000011
-(1,4-бензодиоксан-2-илметил)-1-[1-(1,4-бензодиоксан-5-ил)пиперид-4-ил] метиламин; 1-[1-(1,4-бензодиоксан-2-илметил)пиперид-4-ил]-
Figure 00000012
-(2-метоксифенил)метиламин;
Figure 00000013
-(1,4-бензодиоксан-2-илметил)-1-[1-(4-метоксифенил)пиперид-4-ил] метиламин;
Figure 00000014
(8-метокси-1,4-бензодиоксан-2-илметил)-
Figure 00000015
-(2-метоксифенил)-1,3-пропандиамин;
Figure 00000016
-(1,4-бензодиоксан-2-илметил) -1-[1-(3-метоксифенил)пиперид-4-ил] метиламин;
Figure 00000017
-(1,4- бензодиоксан-2-илметил)-1-[1-(2-хлорфенил)пиперид-4-ил] метиламин;
Figure 00000018
-(5-фтор-1,4-бензодиоксан-2-илметил)-1-[1-(2-метоксифенил)пиперид-4-ил] метиламин;
Figure 00000019
-(8-фтор-1,4-бензодиоксан-2-илметил)-1-[1-(2-метоксифенил)пиперид-4- ил] метиламин; 1-[1-(2,3-дигидробензо[b] фуран-7-ил)пиперид-4-ил] -
Figure 00000020
-(8-метокси-1,4-бензодиоксан-2-илметил)метиламин;
Figure 00000021
-(6-хлор- 1,4-бензодиоксан-2-илметил)-1-[1-(2-метоксифенил)пиперид-4-ил]метиламин;
Figure 00000022
-(7-хлор-1,4-бензодиоксан-2-илметил)-1-[1-(2-метоксифенил)пиперид-4-ил] метиламин;
Figure 00000023
-(8-окси-1,4-бензодиоксан-2-илметил)-1-[1-(2-метоксифенил)пиперид-4-ил] метиламин, и их фармацевтически приемлемые соли, которые могут иметься в виде отдельных энантиомеров, рацематов или других смесей энантиомеров.4. Derivatives of the amine of formula I according to claim 1, selected from the group including
Figure 00000004
- (1,4-benzodioxan-2-ylmethyl) -1- [1- (pyrazin-2-yl) piperid-4-yl] methylamine;
Figure 00000005
- (1,4-benzodioxan-2-ylmethyl) -1- [1- (2-methoxyphenyl) piperid-4-yl] methylamine;
Figure 00000006
- (1,4-benzodioxan-2-ylmethyl) -1- [1- (3-chloropyrid-2-yl) piperide-4-] methylamine;
Figure 00000007
- (1,4-benzodioxan-2-ylmethyl) -1- [1- (quinazolin-4-yl) piperid-4-yl] methylamine;
Figure 00000008
- (1,4-benzodioxan-2-ylmethyl) -1- [1- (piperid-4-yl] methylamine;
Figure 00000009
- (8-methoxy-1,4-benzodioxan-2-ylmethyl) -1- [1- (2-methoxyphenyl) piperid-4-yl] methylamine;
Figure 00000010
- (1,4-benzodioxan-2-ylmethyl) -1- (1-phenylpiperid-4-yl) methylamine;
Figure 00000011
- (1,4-benzodioxan-2-ylmethyl) -1- [1- (1,4-benzodioxan-5-yl) piperid-4-yl] methylamine; 1- [1- (1,4-benzodioxan-2-ylmethyl) piperid-4-yl] -
Figure 00000012
- (2-methoxyphenyl) methylamine;
Figure 00000013
- (1,4-benzodioxan-2-ylmethyl) -1- [1- (4-methoxyphenyl) piperid-4-yl] methylamine;
Figure 00000014
(8-methoxy-1,4-benzodioxan-2-ylmethyl) -
Figure 00000015
- (2-methoxyphenyl) -1,3-propanediamine;
Figure 00000016
- (1,4-benzodioxan-2-ylmethyl) -1- [1- (3-methoxyphenyl) piperid-4-yl] methylamine;
Figure 00000017
- (1,4-benzodioxan-2-ylmethyl) -1- [1- (2-chlorophenyl) piperid-4-yl] methylamine;
Figure 00000018
- (5-fluoro-1,4-benzodioxan-2-ylmethyl) -1- [1- (2-methoxyphenyl) piperid-4-yl] methylamine;
Figure 00000019
- (8-fluoro-1,4-benzodioxan-2-ylmethyl) -1- [1- (2-methoxyphenyl) piperid-4-yl] methylamine; 1- [1- (2,3-dihydrobenzo [b] furan-7-yl) piperid-4-yl] -
Figure 00000020
- (8-methoxy-1,4-benzodioxan-2-ylmethyl) methylamine;
Figure 00000021
- (6-chloro-1,4-benzodioxan-2-ylmethyl) -1- [1- (2-methoxyphenyl) piperid-4-yl] methylamine;
Figure 00000022
- (7-chloro-1,4-benzodioxan-2-ylmethyl) -1- [1- (2-methoxyphenyl) piperid-4-yl] methylamine;
Figure 00000023
- (8-hydroxy-1,4-benzodioxan-2-ylmethyl) -1- [1- (2-methoxyphenyl) piperid-4-yl] methylamine, and their pharmaceutically acceptable salts, which may exist as single enantiomers, racemates or other mixtures of enantiomers. 5. Производные амина формулы I по п.4, выбранные из группы, включающей
Figure 00000024
-(-)-
Figure 00000025
-(1,4-бензодиоксан-2-илметил)-1-[1-(2-метоксифенил)пиперид-4-ил] метиламин;
Figure 00000026
(1,4-бензодиоксан-2-илметил)-1-[1-(2-метоксифенил)пиперид-4-ил] метиламин;
Figure 00000027
(1,4-бензодиоксан-2-илметил)-1-[1-(пирид-2-ил)пиперид-4-ил] метиламин в виде дигидрохлорида;
Figure 00000028
(1,4-бензодиоксан-2-илметил)-1-[1-(пирид-2-4-ил]метиламин в виде дигидрохлорида.5. Derivatives of the amine of formula I according to claim 4, selected from the group including
Figure 00000024
- (-) -
Figure 00000025
- (1,4-benzodioxan-2-ylmethyl) -1- [1- (2-methoxyphenyl) piperid-4-yl] methylamine;
Figure 00000026
(1,4-benzodioxan-2-ylmethyl) -1- [1- (2-methoxyphenyl) piperid-4-yl] methylamine;
Figure 00000027
(1,4-benzodioxan-2-ylmethyl) -1- [1- (pyrid-2-yl) piperid-4-yl] methylamine as dihydrochloride;
Figure 00000028
(1,4-benzodioxan-2-ylmethyl) -1- [1- (pyrid-2-4-yl] methylamine as dihydrochloride. 6. Фармацевтическая композиция со сродством в отношении рецепторов 5-НТ1А и D2, содержащая органическое активное вещество и по меньшей мере один фармацевтически приемлемый разбавитель или носитель, отличающаяся тем, что в качестве органического активного вещества она содержит соединение общей формулы I по п.1 или его соль в эффективном количестве.6. A pharmaceutical composition with an affinity for 5-HT 1A and D 2 receptors, containing an organic active substance and at least one pharmaceutically acceptable diluent or carrier, characterized in that it contains a compound of general formula I as an organic active substance according to 1 or its salt in an effective amount. 7. Способ лечения психозов или шизофрении путем дачи пациенту органического активного вещества, отличающийся тем, что в качестве органического активного вещества используют соединение формулы I по любому из пп.1 - 5 или его соль в терапевтически эффективном количестве. 7. A method of treating psychosis or schizophrenia by giving the patient an organic active substance, characterized in that the compound of formula I according to any one of claims 1 to 5 or a salt thereof in a therapeutically effective amount is used as the organic active substance.
RU96113203A 1993-09-06 1994-09-01 Amine derivatives and pharmaceutical composition on said RU2136680C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9318431.5 1993-09-06
GB939318431A GB9318431D0 (en) 1993-09-06 1993-09-06 Therapeutic agents
PCT/EP1994/002904 WO1995007274A1 (en) 1993-09-06 1994-09-01 Bicyclic aromatic compounds as therapeutic agents

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RU96113203A true RU96113203A (en) 1998-07-20
RU2136680C1 RU2136680C1 (en) 1999-09-10

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Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9514380D0 (en) * 1995-07-13 1995-09-13 Knoll Ag Therapeutic agents
FR2738823B1 (en) * 1995-09-15 1997-10-31 Synthelabo DERIVATIVES OF 3- (OMEGA- (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN- 1-YL) ALKYL) -3,4-DIHYDROQUINOLEIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
GB9526495D0 (en) * 1995-12-23 1996-02-28 Knoll Ag Therapeutic agents
DE19624154A1 (en) 1996-06-18 1998-01-08 Hoechst Ag Ring-fused dihydropyrans, process for their preparation and their use
GB9627006D0 (en) * 1996-12-27 1997-02-12 Knoll Ag Therapeutic agents
GB9627005D0 (en) 1996-12-27 1997-02-12 Knoll Ag Therapeutic agents
FR2760014B1 (en) * 1997-02-27 1999-04-09 Adir NOVEL 2-AMINO INDANE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB9704948D0 (en) 1997-03-11 1997-04-30 Knoll Ag Therapeutic agents
FR2761358B1 (en) * 1997-03-27 1999-05-07 Adir NOVEL N-ARYL PIPERIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US6034256A (en) 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
US6077850A (en) 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
GB9811879D0 (en) * 1998-06-03 1998-07-29 Knoll Ag Therapeutic agents
FR2780057B1 (en) * 1998-06-18 2002-09-13 Sanofi Sa PHENOXYPROPANOLAMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2782515B1 (en) * 1998-08-21 2000-09-22 Adir NEW INDANE-1-Ol DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB9915616D0 (en) * 1999-07-05 1999-09-01 Knoll Ag Therapeutic agents
GB0007376D0 (en) * 2000-03-28 2000-05-17 Knoll Ag Therapeutic agents
US6458804B1 (en) 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6656951B2 (en) 2001-04-24 2003-12-02 Wyeth 8-aza-bicyclo[3.2.1]octan-3-ol derivatives of 2,3-dihydro-1,4-benzodioxan as 5-HT1A antagonists
US6656950B2 (en) 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
EP1381612A1 (en) * 2001-04-26 2004-01-21 Wyeth Antidepressant aza-heterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline
DE10120619A1 (en) * 2001-04-26 2002-10-31 Merck Patent Gmbh 2- (5- (4-fluorophenyl) -3-pyridylmethylaminomethyl-chromane
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US6667322B2 (en) 2001-10-05 2003-12-23 Wyeth Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
US6911445B2 (en) * 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
US7153849B2 (en) * 2002-09-12 2006-12-26 Wyeth Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
FR2884251B1 (en) * 2005-04-08 2007-07-13 Servier Lab PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
US8940764B2 (en) 2005-05-26 2015-01-27 Aldexa Therapeutics, Inc. Compositions and methods of treating retinal disease
TWI457122B (en) * 2007-07-20 2014-10-21 Orion Corp 2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous system diseases
CN109415355A (en) 2016-06-29 2019-03-01 奥赖恩公司 Benzdioxan derivative and its medicinal usage
AU2022303386A1 (en) * 2021-07-02 2023-12-14 Aldeyra Therapeutics, Inc. Heterocyclic aldehyde trapping compounds and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684739A (en) * 1980-12-15 1987-08-04 Mitsubishi Chemical Industries Limited Alkylenedioxybenzene derivatives and acid addition salts thereof
JPS58154574A (en) * 1982-03-09 1983-09-14 Mitsubishi Chem Ind Ltd Alkylenedioxybenzene derivative and its acid adduct salt
US4569933A (en) * 1984-04-13 1986-02-11 Cornu Pierre Jean Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole
CA1260474A (en) * 1984-12-03 1989-09-26 Raymond A. Stokbroekx Benzoxazol- and benzothiazolamine derivatives
US4749702A (en) * 1985-04-15 1988-06-07 Janssen Pharmaceutica N. V. Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
DE3901814A1 (en) * 1988-07-28 1990-02-01 Bayer Ag SUBSTITUTED AMINOMETHYLZETRALINE AND ITS HETEROCYCLIC ANALOG
FR2658823B1 (en) * 1990-02-27 1992-04-30 Adir NOVEL AMINOMETHYLPIPERIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5182292A (en) * 1991-06-21 1993-01-26 American Home Products Corporation Psychotropic piperidinylmethyl benzodioxans
FR2681325B1 (en) * 1991-09-16 1993-12-17 Fabre Medicament Pierre DERIVATIVES OF AMINOMETHYL-4 PIPERIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
SI9300097B (en) * 1992-02-27 2001-12-31 Janssen Pharmaceutica Nv (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines

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