RU96103835A - IMPROVED ENZYMATIC METHOD FOR OBTAINING PENICILLINS AND CEFALOSPORINS - Google Patents

IMPROVED ENZYMATIC METHOD FOR OBTAINING PENICILLINS AND CEFALOSPORINS

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Publication number
RU96103835A
RU96103835A RU96103835/13A RU96103835A RU96103835A RU 96103835 A RU96103835 A RU 96103835A RU 96103835/13 A RU96103835/13 A RU 96103835/13A RU 96103835 A RU96103835 A RU 96103835A RU 96103835 A RU96103835 A RU 96103835A
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RU
Russia
Prior art keywords
formula
acid
immobilized
enzyme
amide
Prior art date
Application number
RU96103835/13A
Other languages
Russian (ru)
Inventor
Дзенони Маурицио
Original Assignee
Эй Си Эс Добфар С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эй Си Эс Добфар С.п.А. filed Critical Эй Си Эс Добфар С.п.А.
Publication of RU96103835A publication Critical patent/RU96103835A/en

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Claims (3)

1. Способ получения пенициллина или цефалоспорина формулы I или II
Figure 00000001

Figure 00000002

где Х - S или СН2;
R - необязательно замещенное шестичленное углеводородное кольцо;
R1 - атом водорода, атом галогена, метильная группа, метоксигруппа, С1 - С4-алкенильная группа или метиленовая группа, соединенная с органическим радикалом через атом кислорода, серы или азота,
по которому 6-амино-пенициллановую кислоту или 7-аминоцефалоспорановую кислоту формулы IV или V
Figure 00000003

Figure 00000004

где Х и R1 имеют указанные значения,
подвергают взаимодействию в водной среде при температуре -5 ... +35oС в присутствии иммобилизованного фермента пенициллинацилазы с амином формулы III
Figure 00000005

где R имеет указанные значения;
R2 и R3 - каждый независимо, водород или линейная или разветвленная С1 - С3-алкильная группа,
или его солью при молярном соотношении от 1,5 до 3 молей указанного амида формулы III на I моль указанной кислоты формулы IV или V, отличающийся тем, что указанный фермент иммобилизован на азалактоновом полимере.1. The method of producing penicillin or cephalosporin of formula I or II
Figure 00000001

Figure 00000002

where X is S or CH 2 ;
R is an optionally substituted six-membered hydrocarbon ring;
R 1 is a hydrogen atom, a halogen atom, a methyl group, a methoxy group, a C 1 - C 4 alkenyl group or a methylene group attached to an organic radical via an oxygen, sulfur or nitrogen atom,
wherein 6-amino-penicillanic acid or 7-aminocephalosporanic acid of formula IV or V
Figure 00000003

Figure 00000004

where X and R 1 have the specified values,
subjected to interaction in an aqueous medium at a temperature of -5 ... +35 o C in the presence of immobilized penicillin acylase enzyme with an amine of formula III
Figure 00000005

where R has the indicated meanings;
R 2 and R 3 are each independently hydrogen or a linear or branched C 1 - C 3 alkyl group,
or its salt at a molar ratio of from 1.5 to 3 moles of the indicated amide of formula III per I mole of the indicated acid of formula IV or V, characterized in that the enzyme is immobilized on an azlactone polymer. 2. Способ по п.1, отличающийся тем, что указанный амид формулы III является D-фенилглициновым амидом или его солью органической или неорганической кислоты. 2. The method according to claim 1, characterized in that said amide of formula III is D-phenylglycine amide or its salt of an organic or inorganic acid. 3. Фермент пенициллинацилаза, иммобилизованный на азалактоновом полимере. 3. The enzyme penicillin acylase immobilized on the aza-lactone polymer.
RU96103835/13A 1995-02-28 1996-02-27 IMPROVED ENZYMATIC METHOD FOR OBTAINING PENICILLINS AND CEFALOSPORINS RU96103835A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI95A000383 1995-02-28

Publications (1)

Publication Number Publication Date
RU96103835A true RU96103835A (en) 1998-05-10

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