RU95122764A - METHOD FOR CLEANING 10-DESACETHYLBACCATIN III AND TAXOTHER - Google Patents

METHOD FOR CLEANING 10-DESACETHYLBACCATIN III AND TAXOTHER

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Publication number
RU95122764A
RU95122764A RU95122764/04A RU95122764A RU95122764A RU 95122764 A RU95122764 A RU 95122764A RU 95122764/04 A RU95122764/04 A RU 95122764/04A RU 95122764 A RU95122764 A RU 95122764A RU 95122764 A RU95122764 A RU 95122764A
Authority
RU
Russia
Prior art keywords
water
mixture
phases
distribution coefficient
heptane
Prior art date
Application number
RU95122764/04A
Other languages
Russian (ru)
Other versions
RU2125563C1 (en
Inventor
Дюран Андре
Жербо Алан
Марграфф Родольф
Original Assignee
Рон-Пуленк Роре С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9303251A external-priority patent/FR2703049B1/en
Application filed by Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А.
Publication of RU95122764A publication Critical patent/RU95122764A/en
Application granted granted Critical
Publication of RU2125563C1 publication Critical patent/RU2125563C1/en

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Claims (10)

1. Способ очистки 10-дезацетилбаккатина III и Таксотера центрифужной распределительной хроматографией между двумя фазами, частично смешивающимися, состоящими из воды и нехлорированных и нетоксичных растворителей, выбранных среди спиртов, простых эфиров, сложных эфиров, кетонов и алифатических углеводородов, отличающийся тем, что при очистке 10-дезацетилбаккатина III используют смесь алифатического углеводорода, сложного эфира, спирта и воды, коэффициент распределения которой между двумя фазами равен 0,1 - 10, или смесь алифатических кетонов и воды, коэффициент распределения которой между двумя фазами равен 0,1 - 10, а при очистке Таксотера используют смесь алифатического углеводорода, сложного эфира, спирта и воды, коэффициент распределения которой между двумя фазами равен 0,1 - 10.1. The method of purification of 10-deacetylbaccatin III and Taxotere by centrifugal distribution chromatography between two phases, partially miscible, consisting of water and non-chlorinated and non-toxic solvents selected among alcohols, ethers, esters, ketones and aliphatic hydrocarbons, characterized in that during the purification 10-deacetylbaccatin III use a mixture of aliphatic hydrocarbon, ester, alcohol and water, the distribution coefficient of which between the two phases is 0.1 to 10, or a mixture of aliphatic ketones and water, the distribution coefficient between the two phases is 0.1 - 10, and when cleaning Taxotere, a mixture of aliphatic hydrocarbon, ester, alcohol and water is used, the distribution coefficient of which between the two phases is 0.1 - 10. 2. Способ по п. 1, отличающийся тем, что коэффициент распределения между двумя фазами равен 0,5 - 5. 2. The method according to p. 1, characterized in that the distribution coefficient between the two phases is 0.5 to 5. 3. Способ по п. 1, отличающийся тем, что коэффициент распределения между двумя фазами близок к 1. 3. The method according to p. 1, characterized in that the distribution coefficient between the two phases is close to 1. 4. Способ по одному из пп. 1 - 3, отличающийся тем, что для выделения 10-дезацетилбаккатина III используют смесь гептана, этилацетата, метанола и воды. 4. The method according to one of paragraphs. 1-3, characterized in that a mixture of heptane, ethyl acetate, methanol and water is used to isolate 10-deacetylbaccatin III. 5. Способ по п. 4, отличающийся тем, что используют смесь гептан-этилацетат-метанол-воды (1-2-1-2 по объему). 5. The method according to p. 4, characterized in that a mixture of heptane-ethyl acetate-methanol-water (1-2-1-2 by volume) is used. 6. Способ по одному из пп. 1 - 3, отличающийся тем, что используют смесь метилизобутилкетона, ацетона и воды. 6. The method according to one of paragraphs. 1 to 3, characterized in that they use a mixture of methyl isobutyl ketone, acetone and water. 7. Способ по п. 6, отличающийся тем, что используют смесь метилизобутилкетон-ацетон-вода (2-3-2 по объему). 7. The method according to p. 6, characterized in that they use a mixture of methyl isobutyl ketone-acetone-water (2-3-2 by volume). 8. Способ по одному из п. 1-3, отличающийся тем, что для очистки Таксотера используют смесь гептана, этилацетата, метанола и воды. 8. The method according to one of p. 1-3, characterized in that for the treatment of Taxotere using a mixture of heptane, ethyl acetate, methanol and water. 9. Способ по п. 8, отличающийся тем, что используют смесь гептан-этилацетат-метанол-вода (2-4-3-2 по объему). 9. The method according to p. 8, characterized in that use a mixture of heptane-ethyl acetate-methanol-water (2-4-3-2 by volume). 10. Тригидрат 3-трет.бутоксикарбониламино-3-фенил-2-окси-(2R, 3S)пропионат 4-ацетокси-2α-бензоилокси-5β, 20-, эпокси-1β, 7β, 10β- триокси-9-оксо-11-таксен-13α-ила или тригидрат Таксотера. 10. 3-tert. Butoxycarbonylamino-3-phenyl-2-hydroxy- (2R, 3S) propionate 4-acetoxy-2α-benzoyloxy-5β, 20-, epoxy-1β, 7β, 10β-trioxy-9-oxo- trihydrate 11-taxen-13α-yl or Taxotere trihydrate.
RU95122764A 1993-03-22 1994-03-18 Method of purification of 10-deacetylbaccatin-iii and taxoter, taxoter trihydrate RU2125563C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9303251A FR2703049B1 (en) 1993-03-22 1993-03-22 Method for the purification of taxoids.
FR9303251 1993-03-22
PCT/FR1994/000300 WO1994021622A1 (en) 1993-03-22 1994-03-18 Method for purifying taxoids

Publications (2)

Publication Number Publication Date
RU95122764A true RU95122764A (en) 1997-11-10
RU2125563C1 RU2125563C1 (en) 1999-01-27

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RU95122764A RU2125563C1 (en) 1993-03-22 1994-03-18 Method of purification of 10-deacetylbaccatin-iii and taxoter, taxoter trihydrate

Country Status (28)

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US (3) US5723635A (en)
EP (1) EP0690852B1 (en)
JP (3) JP3470721B2 (en)
KR (1) KR100320802B1 (en)
CN (2) CN1504465A (en)
AT (1) ATE149160T1 (en)
AU (1) AU687039B2 (en)
CA (1) CA2157905C (en)
CZ (2) CZ283363B6 (en)
DE (1) DE69401810T2 (en)
DK (1) DK0690852T3 (en)
EE (1) EE03100B1 (en)
ES (1) ES2098127T3 (en)
FI (1) FI119023B (en)
FR (1) FR2703049B1 (en)
GE (1) GEP20012581B (en)
GR (1) GR3022681T3 (en)
HU (1) HU221303B1 (en)
LT (1) LT3238B (en)
LV (1) LV11031B (en)
NO (1) NO312403B1 (en)
NZ (1) NZ262917A (en)
PL (1) PL178496B1 (en)
RU (1) RU2125563C1 (en)
SK (2) SK281542B6 (en)
UA (1) UA43333C2 (en)
WO (1) WO1994021622A1 (en)
ZA (1) ZA941968B (en)

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FR2698871B1 (en) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa New taxoids, their preparation and the pharmaceutical compositions containing them.
FR2729666A1 (en) * 1995-01-25 1996-07-26 Rhone Poulenc Rorer Sa PROCESS FOR THE PREPARATION OF (2R, 3S) TRIHYDRATE - BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE OF 4,10-DIACETOXY- 2ALPHA-BENZOYLOXY-5BETA, 20-EPOXY-1,7BETA-DIHYDROXY-9-OX 11-EN-13ALPHA-YLE
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FR2750133B1 (en) * 1996-06-21 1998-08-28 Ifremer METHOD FOR PURIFYING PHOSPHOLIPIDS BY CENTRIFUGAL SHARING CHROMATOGRAPHY
US6174974B1 (en) 1996-07-05 2001-01-16 Bayer Aktiengesellschaft Method for producing thermoplastic elastomers
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US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
US7169307B2 (en) 2004-09-02 2007-01-30 Jian Liu Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
WO2006073519A1 (en) * 2005-01-03 2006-07-13 Teva Pharmaceutical Industries Ltd. Olmesartan medoxomil with reduced levels of impurities
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CN1300131C (en) * 2005-04-27 2007-02-14 浙江钱江生物化学股份有限公司 Separation method for purifying gibberellin GA3
US20070142457A1 (en) * 2005-10-12 2007-06-21 Alessandro Pontiroli Crystalline forms of docetaxel and processes for their preparation
JP2009533330A (en) * 2006-03-21 2009-09-17 ドクター レディズ ラボラトリーズ リミテッド Docetaxel polymorphs and processes
FR2903104B1 (en) * 2006-07-03 2008-09-26 Pierre Fabre Medicament Sa PURIFICATION OF 10-DAB III BY CENTRIFUGAL SHARING CHROMATOGRAPHY
KR101266549B1 (en) * 2006-10-20 2013-05-24 시노팜 싱가포르 피티이 리미티드 Process for making crystalline anhydrous docetaxel
US20100197944A1 (en) * 2007-07-04 2010-08-05 Dr. Reddy's Laboratories Limited Docetaxel process and polymorphs
DE102008031208B4 (en) * 2008-07-03 2010-03-25 Technische Universität Dortmund Process for the large-scale production of taxanes
PL388144A1 (en) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate 4-acetoxy-2?-benzoiloxy-5� ,20-epoxy-1, 7�, 10�-trihydroxy-9-oxo-taks-11 -en-13?-yl solvates, a method for their production and application thereof
US8686165B2 (en) * 2009-11-04 2014-04-01 Emcure Pharmaceuticals Limited Process for preparation of taxane derivatives
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