RU95119837A - Antagonist oxytocin - Google Patents
Antagonist oxytocinInfo
- Publication number
- RU95119837A RU95119837A RU95119837/04A RU95119837A RU95119837A RU 95119837 A RU95119837 A RU 95119837A RU 95119837/04 A RU95119837/04 A RU 95119837/04A RU 95119837 A RU95119837 A RU 95119837A RU 95119837 A RU95119837 A RU 95119837A
- Authority
- RU
- Russia
- Prior art keywords
- oxytocin
- antagonist
- pen
- mercaptopropic
- aginin
- Prior art date
Links
- 101710008205 OXT Proteins 0.000 title 1
- 102100017240 OXT Human genes 0.000 title 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N Oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 title 1
- 229960001723 Oxytocin Drugs 0.000 title 1
- 230000003042 antagnostic Effects 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 101700057139 oxyT Proteins 0.000 title 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
- 229960001230 Asparagine Drugs 0.000 claims 1
- 229960002743 Glutamine Drugs 0.000 claims 1
- 229960000310 ISOLEUCINE Drugs 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- VVNCNSJFMMFHPL-VKHMYHEASA-N Penicillamine Chemical compound CC(C)(S)[C@@H](N)C(O)=O VVNCNSJFMMFHPL-VKHMYHEASA-N 0.000 claims 1
- 229960002429 Proline Drugs 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 239000003336 oxytocin antagonist Substances 0.000 claims 1
- 229940121361 oxytocin antagonists Drugs 0.000 claims 1
- 229960001639 penicillamine Drugs 0.000 claims 1
Claims (1)
где (S)Pmp представляет собой β, β- (3-тиапентаметилен) -β- меркаптопропиновую кислоту, D-Trp представляет собой D-форму триптофана и Ile, Gln, Asn, Pen (Pen является пеницилламином), Pro и Arg представляют собой L-формы изолейцина, глутамина, аспарагина, пролина и агинина соответственно.1. The oxytocin antagonist represented by the formula
where (S) Pmp is β, β- (3-thiapentamethylene) -β-mercaptopropic acid, D-Trp is the D-form of tryptophan and Ile, Gln, Asn, Pen (Pen is penicillamine), Pro and Arg are L-forms of isoleucine, glutamine, asparagine, proline and aginin, respectively.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/052.887 | 1993-04-26 | ||
| US08/052,887 US5373089A (en) | 1988-09-02 | 1993-04-26 | Oxytocin antagonist |
| US08/052,887 | 1993-04-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU95119837A true RU95119837A (en) | 1997-11-10 |
| RU2120944C1 RU2120944C1 (en) | 1998-10-27 |
Family
ID=21980563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU95119837A RU2120944C1 (en) | 1993-04-26 | 1994-11-09 | [(S)Pmp1, D-Trp2, Pen6, Arg8]--OXYTOCIN |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5373089A (en) |
| EP (1) | EP0695309B1 (en) |
| JP (1) | JPH10507995A (en) |
| KR (1) | KR100291304B1 (en) |
| CN (1) | CN1041634C (en) |
| AT (1) | ATE182898T1 (en) |
| AU (1) | AU681399B2 (en) |
| BR (2) | BR9405914A (en) |
| CA (1) | CA2155872C (en) |
| CZ (1) | CZ285388B6 (en) |
| DE (1) | DE69419910T2 (en) |
| DK (1) | DK0695309T3 (en) |
| ES (1) | ES2134351T3 (en) |
| FI (1) | FI105921B (en) |
| GR (1) | GR3031432T3 (en) |
| HU (1) | HU217972B (en) |
| IL (1) | IL108685A (en) |
| NO (1) | NO954260D0 (en) |
| NZ (1) | NZ266049A (en) |
| PL (1) | PL177055B1 (en) |
| RU (1) | RU2120944C1 (en) |
| SK (1) | SK130295A3 (en) |
| WO (1) | WO1994025485A1 (en) |
| ZA (1) | ZA941160B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE501678C2 (en) * | 1993-07-13 | 1995-04-10 | Ferring Bv | Peptide with oxytocin antagonist activity and pharmaceutical composition containing said peptide |
| DK0939632T3 (en) | 1996-02-23 | 2006-01-30 | Lilly Co Eli | Non-peptidyl vasopressin V1a antagonists |
| KR20010006361A (en) | 1997-04-14 | 2001-01-26 | 아사이 이페이 | Permucous Preparation |
| EP0896001A1 (en) * | 1997-08-08 | 1999-02-10 | Daicel Chemical Industries, Ltd. | Method for preparing oxytocin antagoniste derivatives, intermediates for the preparation of oxytocin antagonist derivatives and method for preparing the intermediates |
| JP2003335797A (en) * | 2000-06-28 | 2003-11-28 | Daicel Chem Ind Ltd | Peptide compound and medicine composition containing the compound as active ingredient |
| EP1555029A1 (en) * | 2004-01-19 | 2005-07-20 | Ferring B.V. | Use of substances having oxytocin antagonistic properties for the preparation of a medicament for treating hypertension |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4597901A (en) * | 1984-12-14 | 1986-07-01 | Smithkline Beckman Corporation | β-indolylalanyl or β-indolylglycinyl vasopressin antagonists |
| US4711877A (en) * | 1985-09-18 | 1987-12-08 | Smithkline Beckman Corporation | 6-pen-vasopressin compounds |
| WO1990002756A1 (en) * | 1988-09-02 | 1990-03-22 | Northwestern University | Oxytocin antagonist |
| US5070187A (en) * | 1989-11-03 | 1991-12-03 | Trustees Of Boston University | Pharmacologically effective antagonists of arginine-vasopressin |
-
1993
- 1993-04-26 US US08/052,887 patent/US5373089A/en not_active Expired - Fee Related
-
1994
- 1994-02-09 DE DE69419910T patent/DE69419910T2/en not_active Expired - Fee Related
- 1994-02-09 HU HU9502366A patent/HU217972B/en not_active IP Right Cessation
- 1994-02-09 CZ CZ952778A patent/CZ285388B6/en not_active IP Right Cessation
- 1994-02-09 AT AT94915332T patent/ATE182898T1/en active
- 1994-02-09 KR KR1019950704748A patent/KR100291304B1/en not_active IP Right Cessation
- 1994-02-09 SK SK1302-95A patent/SK130295A3/en unknown
- 1994-02-09 AU AU66630/94A patent/AU681399B2/en not_active Ceased
- 1994-02-09 DK DK94915332T patent/DK0695309T3/en active
- 1994-02-09 JP JP6524234A patent/JPH10507995A/en active Pending
- 1994-02-09 CA CA002155872A patent/CA2155872C/en not_active Expired - Fee Related
- 1994-02-09 ES ES94915332T patent/ES2134351T3/en not_active Expired - Lifetime
- 1994-02-09 CN CN94191909A patent/CN1041634C/en not_active Expired - Fee Related
- 1994-02-09 NZ NZ266049A patent/NZ266049A/en unknown
- 1994-02-09 PL PL94311475A patent/PL177055B1/en unknown
- 1994-02-09 BR BR9405914A patent/BR9405914A/en not_active Application Discontinuation
- 1994-02-09 WO PCT/US1994/001439 patent/WO1994025485A1/en active IP Right Grant
- 1994-02-09 EP EP94915332A patent/EP0695309B1/en not_active Expired - Lifetime
- 1994-02-17 IL IL108685A patent/IL108685A/en not_active IP Right Cessation
- 1994-02-21 ZA ZA941160A patent/ZA941160B/en unknown
- 1994-11-09 RU RU95119837A patent/RU2120944C1/en active
-
1995
- 1995-07-31 FI FI953646A patent/FI105921B/en active
- 1995-10-25 NO NO954260A patent/NO954260D0/en not_active Application Discontinuation
-
1997
- 1997-05-14 BR BR1101113-0A patent/BR1101113A/en active IP Right Grant
-
1999
- 1999-10-07 GR GR990402521T patent/GR3031432T3/en unknown
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