RU95119827A - NEW DERIVATIVES PRE-VISIBLE - Google Patents

NEW DERIVATIVES PRE-VISIBLE

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Publication number
RU95119827A
RU95119827A RU95119827/04A RU95119827A RU95119827A RU 95119827 A RU95119827 A RU 95119827A RU 95119827/04 A RU95119827/04 A RU 95119827/04A RU 95119827 A RU95119827 A RU 95119827A RU 95119827 A RU95119827 A RU 95119827A
Authority
RU
Russia
Prior art keywords
formula
compound
mixture
compounds
diseases
Prior art date
Application number
RU95119827/04A
Other languages
Russian (ru)
Other versions
RU2132854C1 (en
Inventor
Амшлер Херманн
Флокерци Дитер
Ридель Рихард
Постиус Стефан
Штоек Михаэль
Бойме Рольф
Цех Карл
Гуттерер Беате
Original Assignee
Бик Гульден Ломберг Хемише Фабрик ГмбХ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бик Гульден Ломберг Хемише Фабрик ГмбХ filed Critical Бик Гульден Ломберг Хемише Фабрик ГмбХ
Priority claimed from PCT/EP1994/001015 external-priority patent/WO1994022899A1/en
Publication of RU95119827A publication Critical patent/RU95119827A/en
Application granted granted Critical
Publication of RU2132854C1 publication Critical patent/RU2132854C1/en

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Claims (10)

1. Соединение формулы I
Figure 00000001

с химическим названием 16α, 17-(22R,S)-циклогексилметилендиокси--11β,21--дигидроксипрегна -1,4-диен-3,20 -дион.1. The compound of formula I
Figure 00000001

with the chemical name 16α, 17- (22R, S) -cyclohexylmethylenedioxy - 11β, 21 - dihydroxypregna -1,4-diene-3,20-dione. 2. Соединение формулы Iа по п.1
Figure 00000002

с химическим названием 16α, 17-(22R)-циклогексилметилендиокси-11β,21-дигидроксипрегна-1,4-диен-3,20- дион.2. The compound of formula Ia according to claim 1
Figure 00000002

with the chemical name 16α, 17- (22R) -cyclohexylmethylenedioxy-11β, 21-dihydroxypregna-1,4-diene-3,20-dione. 3. Соединение формулы Iб по пп. 1 и 2
Figure 00000003

с химическим названием 16α, 17-(22S)-циклогексилметилендиокси-11β,21-дигидроксипрегна-1,4-диен-3,20-дион.3. The compound of formula Ib on PP. 1 and 2
Figure 00000003

with the chemical name 16α, 17- (22S) -cyclohexylmethylenedioxy-11β, 21-dihydroxypregna-1,4-diene-3,20-dione. 4. Соединение формулы I по пп. 1 - 3, отличающееся тем, что формула I для смеси эпимеров соединения Iа
Figure 00000004

и соединение формулы Iб
Figure 00000005

имеют любое соотношение компонентов смеси.4. The compound of formula I PP. 1 to 3, characterized in that formula I for a mixture of epimeric compounds Ia
Figure 00000004

and the compound of formula Ib
Figure 00000005

have any ratio of mixture components. 5. Способ получения соединения формулы 1 по пп. 1 - 3, отличающийся тем, что 16-гидроксипреднизолон вводят во взаимодействие с циклогексанальдегидом. 5. The method of obtaining the compounds of formula 1 according to claims. 1 to 3, characterized in that the 16-hydroxyprednisolone enter into interaction with cyclohexanaldehyde. 6. Лекарственное средство, содержащее соединение формулы I по пп. 1 - 4, в виде смеси эпимеров соединений Iа и Iб в любом соотношении компонентов смеси. 6. Drug containing a compound of the formula I on PP. 1 to 4, in the form of a mixture of epimers of compounds Ia and Ib in any ratio of components of the mixture. 7. Лекарственное средство, содержащее соединение формулы Iа по п. 2. 7. Drug containing a compound of formula Ia under item 2. 8. Лекарственное средство, содержащее соединение формулы Iб по п. 3. 8. A medicament containing a compound of formula Ib according to claim 3. 9. Соединение по одному из пп. 1 - 4 для применения при лечении или профилактике заболевания кожи, заболеваний дыхательных путей, воспалительных заболеваний кишечника и аллергических ринитов/конъюнктивитов. 9. Connection in one of the paragraphs. 1 - 4 for use in the treatment or prevention of skin diseases, respiratory diseases, inflammatory bowel diseases and allergic rhinitis / conjunctivitis. 10. Применение соединения по одному из п. 1, или 2, или 3 для изготовления лекарственных средств для лечения и/или профилактики заболеваний кожи, заболеваний дыхательных путей, воспалительных заболеваний кишечника и аллергических ринитов/конъюнктивитов. 10. The use of compounds according to one of p. 1, or 2, or 3 for the manufacture of medicines for the treatment and / or prevention of skin diseases, respiratory diseases, inflammatory bowel diseases and allergic rhinitis / conjunctivitis.
RU95119827A 1993-04-02 1994-03-31 Derivatives of prednisolone, method of their synthesis and drug RU2132854C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH1023/93-1 1993-04-02
CH102393 1993-04-02
PCT/EP1994/001015 WO1994022899A1 (en) 1993-04-02 1994-03-31 New prednisolone derivates

Publications (2)

Publication Number Publication Date
RU95119827A true RU95119827A (en) 1997-11-10
RU2132854C1 RU2132854C1 (en) 1999-07-10

Family

ID=4200650

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95119827A RU2132854C1 (en) 1993-04-02 1994-03-31 Derivatives of prednisolone, method of their synthesis and drug

Country Status (21)

Country Link
US (1) US5733901A (en)
EP (1) EP0701565B1 (en)
JP (1) JP3333210B2 (en)
KR (1) KR100330941B1 (en)
CN (1) CN1062869C (en)
AT (1) ATE172739T1 (en)
AU (1) AU683463B2 (en)
BG (1) BG62491B1 (en)
CZ (1) CZ287877B6 (en)
DE (1) DE59407183D1 (en)
DK (1) DK0701565T3 (en)
ES (1) ES2124884T3 (en)
FI (1) FI113543B (en)
HU (1) HU220868B1 (en)
NO (1) NO305990B1 (en)
NZ (1) NZ265054A (en)
PL (1) PL179489B1 (en)
RU (1) RU2132854C1 (en)
SK (1) SK281226B6 (en)
UA (1) UA45311C2 (en)
WO (1) WO1994022899A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19635498A1 (en) * 1996-09-03 1998-03-26 Byk Gulden Lomberg Chem Fab Process for epimer enrichment
DE10055820C1 (en) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Preparation of 16,17-cyclohexylmethylene-dioxy-pregnadiene derivative, useful as glucocorticoid, by reacting 16,17-ketal with cyclohexylaldehyde to give high epimeric purity
PL205674B1 (en) * 2000-11-10 2010-05-31 Nycomed Gmbh Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation
KR101067795B1 (en) 2002-08-30 2011-09-27 니코메드 게엠베하 The use of the combination of ciclesonide and antihistamines for the treatment of allergic rhinitis
DK1572217T3 (en) 2002-12-12 2008-12-15 Nycomed Gmbh Combination drug of R, R-formoterol and ciclesonide
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
WO2004110460A1 (en) * 2003-06-13 2004-12-23 Altana Pharma Ag Formoterol and ciclesonide combination
CA2538202C (en) * 2003-09-15 2013-01-15 Altana Pharma Ag Use of ciclesonide for the treatment of inflammatory bowel diseases
ES2452691T5 (en) 2003-09-16 2022-09-14 Covis Pharma Gmbh Use of ciclesonide for the treatment of respiratory diseases
PE20050941A1 (en) 2003-12-16 2005-11-08 Nycomed Gmbh AQUEOUS CYCLESOUND SUSPENSIONS FOR MISTING
JP2007533706A (en) * 2004-04-20 2007-11-22 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Use of ciclesonide for the treatment of respiratory diseases in smoking patients
JP2008512428A (en) * 2004-09-10 2008-04-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Combination of ciclesonide and Syk inhibitor and method of use thereof
CN100345864C (en) * 2004-10-29 2007-10-31 天津药业研究院有限公司 Preparation method of steroid medicine for treating respiration channel disease and its intermediate
US20100209508A1 (en) * 2005-06-14 2010-08-19 Corus Pharma, Inc. Substituted Phenylphosphates as Mutual Prodrugs of Steroids and ß-Agonists for the Treatment of Title Pulmonary Inflammation and Bronchoconstriction
WO2007054974A2 (en) * 2005-09-28 2007-05-18 Arch Pharmalab Limited A green chemistry process for the preparation of pregnadiene esters
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
JP2010503722A (en) * 2006-09-19 2010-02-04 シプラ・リミテッド Process for the preparation of ciclesonide and its crystal variants
EP2262823B1 (en) * 2008-03-13 2013-01-23 Farmabios S.p.A. Process for the preparation of pregnane derivatives
ITMI20080645A1 (en) * 2008-04-11 2009-10-12 Ind Chimica Srl PROCEDURE FOR THE PREPARATION OF BUDESONIDE
CN102348714B (en) * 2009-03-09 2015-01-07 三笠制药株式会社 Steroid compound
WO2011135585A2 (en) 2010-04-28 2011-11-03 Cadila Healthcare Limited Aqueous pharmaceutical solution of ciclesonide
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
CN103421075B (en) * 2012-05-16 2017-07-28 上海特化医药科技有限公司 The preparation method of the acetal of pregnane derivatives 16,17 (ketone)
US20180126000A1 (en) 2016-06-02 2018-05-10 Abbvie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
KR20200095477A (en) 2017-12-01 2020-08-10 애브비 인코포레이티드 Glucocorticoid receptor agonists and immunoconjugates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990401A (en) * 1958-06-18 1961-06-27 American Cyanamid Co 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
GB1382614A (en) * 1972-01-10 1975-02-05 Squibb & Sons Inc Steroid compositions
IT1196142B (en) * 1984-06-11 1988-11-10 Sicor Spa PROCEDURE FOR THE PREPARATION OF 16.17-ACETALS OF PREGNANIC DERIVATIVES AND NEW COMPOUNDS OBTAINED
GR1001529B (en) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Process for the obtainment of a new pregna-1,4-diene-3,20-dione -16-17-acetal-21 esters

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