RU95118878A - INTERMEDIATE COMPOUNDS AND THEIR OBTAINING FOR BENZIMIDAZOLE DERIVATIVES - Google Patents

INTERMEDIATE COMPOUNDS AND THEIR OBTAINING FOR BENZIMIDAZOLE DERIVATIVES

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Publication number
RU95118878A
RU95118878A RU95118878/04A RU95118878A RU95118878A RU 95118878 A RU95118878 A RU 95118878A RU 95118878/04 A RU95118878/04 A RU 95118878/04A RU 95118878 A RU95118878 A RU 95118878A RU 95118878 A RU95118878 A RU 95118878A
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RU
Russia
Prior art keywords
formula
group
values
compound
paragraph
Prior art date
Application number
RU95118878/04A
Other languages
Russian (ru)
Other versions
RU2144022C1 (en
Inventor
Нака Такехико
Нисикава Кохеи
Original Assignee
Такеда Кемикал Индастриз, Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Такеда Кемикал Индастриз, Лтд. filed Critical Такеда Кемикал Индастриз, Лтд.
Priority to RU95118878A priority Critical patent/RU2144022C1/en
Priority claimed from RU95118878A external-priority patent/RU2144022C1/en
Publication of RU95118878A publication Critical patent/RU95118878A/en
Application granted granted Critical
Publication of RU2144022C1 publication Critical patent/RU2144022C1/en

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Claims (3)

1. Соединение формулы
Figure 00000001

где R2 и R3 каждый представляет группу, способную образовывать анион или группу, которая может быть превращена в анион;
кольцо А представляет бензольное кольцо, которое, необязательно помимо группы, представленной R2, имеет дополнительные заместители;
Х представляет связь фениленовой группы и фенильной, непосредственную или через пространственную группу, чья атомная цепь не превышает 2;
Q2 представляет -NO2 или -NH2, когда Q1 представляет Н, или Q2 означает - NO2, когда Q1 означает - СООR, где R означает низший (С1-С2) алкил, или соль этого соединения.1. The compound of the formula
Figure 00000001

where R 2 and R 3 each represents a group capable of forming an anion or a group that can be converted into an anion;
ring A represents a benzene ring, which, optionally, in addition to the group represented by R 2 , has additional substituents;
X represents the bond of the phenylene group and the phenyl group, directly or through a space group, whose atomic chain does not exceed 2;
Q 2 is -NO 2 or -NH 2 when Q 1 is H, or Q 2 represents - NO 2 when Q 1 is - COOR, where R is a lower (C 1 -C 2) alkyl, or a salt thereof. 2. Соединение по п. 1, представляющее собой метил 3- амино- 2 - [[(2'- цианобифенил - 4- ил) метил]амино]бензоат. 2. The compound according to claim 1, which is methyl 3-amino-2 - [[(2'-cyanobiphenyl-4-yl) methyl] amino] benzoate. 3. Способ получения соединения формулы
Figure 00000002

где значения А, R2, R3, Q1, Q2 и Х даны в п. 1,
или их солей, отличающийся тем, что сложный эфир карбаминовой кислоты общей формулы
Figure 00000003

где A, R и R2 имеют значения, указанные в п. 1, подвергают реакции алкилирования с алкилирующим агентом формулы
Figure 00000004

где W означает атом галогена;
Х и R2 имеют значения, указанные в п. 1, после чего полученное соединение формулы
Figure 00000005

где значения А, R, R2, R3 и Х указаны выше,
необязательно подвергают реакции снятия защитной группы для получения соединения формулы
Figure 00000006

где значения R2, R3, А и Х указаны выше,
с последующим необязательным восстановлением полученного соединения до соединения формулы
Figure 00000007

где значения R2, R3, А и Х указаны выше.3. The method of obtaining the compounds of formula
Figure 00000002

where the values of A, R 2 , R 3 , Q 1 , Q 2 and X are given in paragraph 1,
or their salts, characterized in that the ester of carbamic acid of General formula
Figure 00000003

where A, R and R 2 have the meanings indicated in paragraph 1, is subjected to alkylation reaction with an alkylating agent of the formula
Figure 00000004

where W means a halogen atom;
X and R 2 have the meanings indicated in paragraph 1, after which the resulting compound of the formula
Figure 00000005

where the values of A, R, R 2 , R 3 and X are as indicated above,
optionally subjected to the reaction of removing the protective group to obtain the compounds of formula
Figure 00000006

where the values of R 2 , R 3 , A and X above,
followed by the optional reduction of the obtained compound to a compound of the formula
Figure 00000007

where the values of R 2 , R 3 , A and X are as indicated above.
RU95118878A 1995-10-30 1995-10-30 N-(biphenylmethyl)aminobenzoic acid esters and method of their synthesis RU2144022C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU95118878A RU2144022C1 (en) 1995-10-30 1995-10-30 N-(biphenylmethyl)aminobenzoic acid esters and method of their synthesis

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP01277385 1989-10-24
JP01328974 1989-12-18
JP02005147 1990-01-11
JP02091675 1990-04-05
JP02097324 1990-04-11
JP02113145 1990-04-27
RU95118878A RU2144022C1 (en) 1995-10-30 1995-10-30 N-(biphenylmethyl)aminobenzoic acid esters and method of their synthesis

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU5010114 Division 1990-10-23

Publications (2)

Publication Number Publication Date
RU95118878A true RU95118878A (en) 1997-09-20
RU2144022C1 RU2144022C1 (en) 2000-01-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU95118878A RU2144022C1 (en) 1995-10-30 1995-10-30 N-(biphenylmethyl)aminobenzoic acid esters and method of their synthesis

Country Status (1)

Country Link
RU (1) RU2144022C1 (en)

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