RU95118407A - METHOD FOR PRODUCING (S) -2- (3-BENZOYLPHENYL) PROPIONIC ACID FROM A MIXTURE OF ITS ANALYTOMETERS OF ITS ALKYL ETHER - Google Patents

METHOD FOR PRODUCING (S) -2- (3-BENZOYLPHENYL) PROPIONIC ACID FROM A MIXTURE OF ITS ANALYTOMETERS OF ITS ALKYL ETHER

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Publication number
RU95118407A
RU95118407A RU95118407/13A RU95118407A RU95118407A RU 95118407 A RU95118407 A RU 95118407A RU 95118407/13 A RU95118407/13 A RU 95118407/13A RU 95118407 A RU95118407 A RU 95118407A RU 95118407 A RU95118407 A RU 95118407A
Authority
RU
Russia
Prior art keywords
propionic acid
benzoylphenyl
mixture
analytometers
producing
Prior art date
Application number
RU95118407/13A
Other languages
Russian (ru)
Other versions
RU2129615C1 (en
Inventor
Белинда Хэзел Уорнек Джули
Энтони Уиздом Ричард
Original Assignee
Лабораториос Менарини С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939304256A external-priority patent/GB9304256D0/en
Application filed by Лабораториос Менарини С.А. filed Critical Лабораториос Менарини С.А.
Publication of RU95118407A publication Critical patent/RU95118407A/en
Application granted granted Critical
Publication of RU2129615C1 publication Critical patent/RU2129615C1/en

Links

Claims (7)

1. Способ получения (s)-2-(3-бензоилфенил) пропионовой кислоты из смеси энантиомеров алкильного эфира 2-(3-бензоил-фенил) пропионовой кислоты с применением биокатализатора, отличающийся тем, что в качестве биокатализатора применяют организм рода Ophistoma или Ceratocystis, или вещества, имеющие ферментативную активность на основе этого микроорганизма.1. The method of obtaining (s) -2- (3-benzoylphenyl) propionic acid from a mixture of enantiomers of the alkyl ester of 2- (3-benzoyl-phenyl) propionic acid using a biocatalyst, characterized in that an organism of the genus Ophistoma or Ceratocystis is used as a biocatalyst , or substances having enzymatic activity based on this microorganism. 2. Способ по п.1, отличающийся тем, что получают миниум 93% (s)-2-(3-бензоилфенил) пропионовой кислоты при степени превращения, равной 15-25%. 2. The method according to claim 1, characterized in that a minimum of 93% (s) -2- (3-benzoylphenyl) propionic acid is obtained with a conversion of 15-25%. 3. Способ по п.1или2, отличающийся тем, что биокатализатор представляет микроорганизм Ophiostoma novo-ulmi, IMI 356050. 3. The method according to claim 1 or 2, characterized in that the biocatalyst is a microorganism Ophiostoma novo-ulmi, IMI 356050. 4. Способ по п.3, отличающийся тем, что эфир алкильная часть имеет от 1 до 3 углеродных атомов. 4. The method according to claim 3, characterized in that the ether alkyl part has from 1 to 3 carbon atoms. 5. Способ по п.4, отличающийся тем, что алкильная часть эфира представляет собой этил. 5. The method according to claim 4, characterized in that the alkyl part of the ether is ethyl. 6. Способ по любому предшествующему пункту, отличающийся тем, что реакцию проводят при pH от 8 до 11. 6. The method according to any preceding paragraph, characterized in that the reaction is carried out at a pH of from 8 to 11. 7. Способ по любому предшествующему пункту, отличающийся тем, что реакцию проводят при pH от 9,5 до 10,5. 7. The method according to any preceding paragraph, characterized in that the reaction is carried out at a pH of from 9.5 to 10.5.
RU95118407A 1993-03-03 1994-03-03 Method of producing (s)-2-(3-benzoylphenyl)-propionic acid from mixture of its alkyl ester enantiomers RU2129615C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9304256.2 1993-03-03
GB939304256A GB9304256D0 (en) 1993-03-03 1993-03-03 Arylalkanoic acid resolution
PCT/EP1994/000630 WO1994020633A1 (en) 1993-03-03 1994-03-03 Arylalkanoic acid resolution

Publications (2)

Publication Number Publication Date
RU95118407A true RU95118407A (en) 1998-12-27
RU2129615C1 RU2129615C1 (en) 1999-04-27

Family

ID=10731341

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95118407A RU2129615C1 (en) 1993-03-03 1994-03-03 Method of producing (s)-2-(3-benzoylphenyl)-propionic acid from mixture of its alkyl ester enantiomers

Country Status (19)

Country Link
EP (1) EP0693134B1 (en)
KR (1) KR100308411B1 (en)
AT (1) ATE154831T1 (en)
AU (1) AU675700B2 (en)
CA (1) CA2157369C (en)
CZ (1) CZ283262B6 (en)
DE (2) DE693134T1 (en)
DK (1) DK0693134T3 (en)
ES (1) ES2087046T3 (en)
FI (1) FI104327B (en)
GB (1) GB9304256D0 (en)
GR (2) GR960300037T1 (en)
HK (1) HK1006469A1 (en)
HU (1) HU218409B (en)
NO (1) NO318371B1 (en)
PL (1) PL177324B1 (en)
RU (1) RU2129615C1 (en)
SK (1) SK280049B6 (en)
WO (1) WO1994020633A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9607458D0 (en) 1996-04-10 1996-06-12 Zeneca Ltd Enzymatic process for stereoselective preparation of therapeutic amides
EP1626093A1 (en) * 2004-08-11 2006-02-15 Dow Global Technologies Inc. Process for the production of (S)-5-chloro-2-isopropylpent-4-enoic acid esters
IT1402974B1 (en) 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa PROCESS FOR NEBIVOLOL PREPARATION.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600245D0 (en) * 1986-01-07 1986-02-12 Shell Int Research Preparation of 2-arylpropionic acids
US5108916A (en) * 1989-06-05 1992-04-28 Rhone-Poulenc Rorer, S.A. Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa
GB9118149D0 (en) * 1991-08-22 1991-10-09 Enzymatix Ltd Araylalkanoic acid resolution
ES2046950B1 (en) * 1992-06-08 1994-10-01 Menarini Lab PROCESS FOR THE PRODUCTION OF ACID S - (+) - 2- (3-BENZOILFENIL) PROPIONICO BY ENZYMATICALLY CATALYZED ENANTIOUS HYDROLYSIS.
ATE161890T1 (en) * 1992-06-08 1998-01-15 Menarini Lab METHOD FOR PRODUCING S-(+)-2-(- 3BENZOYLPHENYL)PROPIONIC ACID BY ENZYME-CATALYzed ENANTHIOSELECTIVE TRANSESTERATION IN AN ORGANIC SOLVENT.

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