RU95115761A - 4- (N, N, N-TRIMETHYLAMINO) -CINNAMOEL DERIVATIVES OF FIBRINOLYTIC ENZYMES AS A PROLONGED THROMBOLYTIC MEANS AND METHOD FOR THEIR PRODUCTION - Google Patents

4- (N, N, N-TRIMETHYLAMINO) -CINNAMOEL DERIVATIVES OF FIBRINOLYTIC ENZYMES AS A PROLONGED THROMBOLYTIC MEANS AND METHOD FOR THEIR PRODUCTION

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Publication number
RU95115761A
RU95115761A RU95115761/14A RU95115761A RU95115761A RU 95115761 A RU95115761 A RU 95115761A RU 95115761/14 A RU95115761/14 A RU 95115761/14A RU 95115761 A RU95115761 A RU 95115761A RU 95115761 A RU95115761 A RU 95115761A
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RU
Russia
Prior art keywords
trimethylamino
derivatives
cinnamoel
production
fibrinolytic enzymes
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Application number
RU95115761/14A
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Russian (ru)
Other versions
RU2121362C1 (en
Inventor
Р.Б. Айсина
С.Д. Варфоломеев
Original Assignee
Р.Б. Айсина
С.Д. Варфоломеев
Filing date
Publication date
Application filed by Р.Б. Айсина, С.Д. Варфоломеев filed Critical Р.Б. Айсина
Priority to RU95115761A priority Critical patent/RU2121362C1/en
Priority claimed from RU95115761A external-priority patent/RU2121362C1/en
Publication of RU95115761A publication Critical patent/RU95115761A/en
Application granted granted Critical
Publication of RU2121362C1 publication Critical patent/RU2121362C1/en

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Claims (2)

1. 4-(N,N,N-триметиламино)-циннамоильные производные фибринолитических ферментов общей формулы
Figure 00000001

где Е - урокиназа, тканевый активатор плазминогена, плазмин, плазмин-стрептокиназаактиваторный комплекс, плазминоген-стрептокиназаактиваторный комплекс,
в качестве пролонгированных тромболитических агентов.1. 4- (N, N, N-trimethylamino) -cinnamoyl derivatives of fibrinolytic enzymes of the general formula
Figure 00000001

where E is urokinase, tissue plasminogen activator, plasmin, plasmin-streptokinase activator complex, plasminogen-streptokinase activator complex,
as prolonged thrombolytic agents. 2. Способ получения соединения по п.1, заключающийся в том, что фибринолитический фермент ацилируют по серину активного центра избытком 4-нитрофенилового эфира цис- или транс-изомеров 4-(N,N,N-триметиламино)-коричной кислоты с последующим выделением целевого продукта гельфильтрацией или ультрафильтрацией. 2. The method of producing the compound according to claim 1, which consists in acylation of the fibrinolytic enzyme on the serine of the active center with an excess of 4-nitrophenyl ester of cis or trans isomers of 4- (N, N, N-trimethylamino) -cyric acid target product gel filtration or ultrafiltration.
RU95115761A 1995-09-08 1995-09-08 The prolonged thrombolytic agent and a method of its preparing RU2121362C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU95115761A RU2121362C1 (en) 1995-09-08 1995-09-08 The prolonged thrombolytic agent and a method of its preparing

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU95115761A RU2121362C1 (en) 1995-09-08 1995-09-08 The prolonged thrombolytic agent and a method of its preparing

Publications (2)

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RU95115761A true RU95115761A (en) 1997-09-10
RU2121362C1 RU2121362C1 (en) 1998-11-10

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