RU95114383A - METHOD FOR PRODUCING IMMUNO DEPRESSANTS AND A NEW MICROBIOLOGICAL VIEW FOR ITS IMPLEMENTATION - Google Patents
METHOD FOR PRODUCING IMMUNO DEPRESSANTS AND A NEW MICROBIOLOGICAL VIEW FOR ITS IMPLEMENTATIONInfo
- Publication number
- RU95114383A RU95114383A RU95114383/13A RU95114383A RU95114383A RU 95114383 A RU95114383 A RU 95114383A RU 95114383/13 A RU95114383/13 A RU 95114383/13A RU 95114383 A RU95114383 A RU 95114383A RU 95114383 A RU95114383 A RU 95114383A
- Authority
- RU
- Russia
- Prior art keywords
- cbs
- tolypocladium
- cyclosporin
- strain
- depressants
- Prior art date
Links
- 239000003018 immunosuppressive agent Substances 0.000 title claims 3
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 230000002906 microbiologic Effects 0.000 title 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17 Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 4
- 108010036949 Cyclosporine Proteins 0.000 claims 4
- 229960001265 ciclosporin Drugs 0.000 claims 4
- 241001079967 Tolypocladium sp. Species 0.000 claims 3
- 235000015097 nutrients Nutrition 0.000 claims 3
- 235000013312 flour Nutrition 0.000 claims 2
- 230000001861 immunosuppresant Effects 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 229960003444 IMMUNOSUPPRESSANTS Drugs 0.000 claims 1
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 1
- 241001149964 Tolypocladium Species 0.000 claims 1
- 235000012343 cottonseed oil Nutrition 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 235000013379 molasses Nutrition 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
Claims (6)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI925940 | 1992-12-30 | ||
FI925940A FI92334C (en) | 1992-12-30 | 1992-12-30 | Process for producing cyclosporins and new Tolypocladium strain useful in the process |
PCT/FI1993/000568 WO1994016091A1 (en) | 1992-12-30 | 1993-12-29 | A process for producing immunosuppressives and a novel microbial species to be employed therein |
Publications (2)
Publication Number | Publication Date |
---|---|
RU95114383A true RU95114383A (en) | 1997-07-20 |
RU2112807C1 RU2112807C1 (en) | 1998-06-10 |
Family
ID=8536483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU95114383A RU2112807C1 (en) | 1992-12-30 | 1993-12-29 | Method of preparing immunodepressant cyclosporin a and a strain tolypocladium species cbs 630 92 producing cyclosporin a |
Country Status (20)
Country | Link |
---|---|
US (1) | US5409816A (en) |
EP (1) | EP0677116B1 (en) |
JP (1) | JP3530531B2 (en) |
KR (1) | KR100283503B1 (en) |
AT (1) | ATE196655T1 (en) |
AU (1) | AU674723B2 (en) |
CA (1) | CA2152963C (en) |
DE (1) | DE69329500T2 (en) |
DK (1) | DK0677116T3 (en) |
EE (1) | EE03114B1 (en) |
ES (1) | ES2150980T3 (en) |
FI (1) | FI92334C (en) |
GR (1) | GR3035139T3 (en) |
HK (1) | HK1014035A1 (en) |
HU (1) | HU217683B (en) |
PL (1) | PL177023B1 (en) |
PT (1) | PT677116E (en) |
RU (1) | RU2112807C1 (en) |
SG (1) | SG49072A1 (en) |
WO (1) | WO1994016091A1 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0725076B1 (en) * | 1995-02-01 | 2001-06-06 | National Research Development Corporation of India | A process for the preparation of cyclosporin A from tolypocladium species |
KR100360675B1 (en) * | 1995-02-28 | 2003-01-14 | 내셔널 리서어치 디벨럽먼트 코포레이션 | How to make cyclosporine A |
US5747330A (en) * | 1996-06-05 | 1998-05-05 | Poli Industria Chimica | Antibiotic producing microbe |
US5709797A (en) * | 1996-06-05 | 1998-01-20 | Poli Industria Chimica S.P.A. | Method of isolating cyclosporins |
HU223054B1 (en) * | 1997-03-25 | 2004-03-01 | BIOGAL Gyógyszergyár Rt. | Purification process for producing high purity ciklosporin a |
US6423233B1 (en) * | 2000-08-15 | 2002-07-23 | Biogal Gyogyszergyar Rt. | Purification process |
KR100496929B1 (en) * | 1997-03-25 | 2005-09-30 | 테바 기오기스제르갸르 레스즈베니타르사사그 | Method of Purifying Cyclosporin |
ATE423130T1 (en) | 1997-10-08 | 2009-03-15 | Isotechnika Inc | DEUTERATED CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS |
US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
WO2000040219A1 (en) | 1998-12-30 | 2000-07-13 | Dexcel Ltd. | Dispersible concentrate for the delivery of cyclosporin |
US7732404B2 (en) * | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
CN1406124A (en) * | 2000-01-20 | 2003-03-26 | 巴斯利尔药物股份公司 | Nasally administrable cyclic peptide compositions |
US7176001B1 (en) * | 2000-02-29 | 2007-02-13 | Biocon Limited | Manufacture and purification of cyclosporin A |
CA2461740C (en) | 2001-10-19 | 2013-02-12 | Isotechnika Inc. | Synthesis of cyclosporin analogs |
US7862552B2 (en) * | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
EP2151450A1 (en) * | 2008-07-29 | 2010-02-10 | Sandoz AG | Method for processing microbiologically produced cyclic oligopeptides |
WO2019067423A1 (en) * | 2017-09-29 | 2019-04-04 | Valent Biosciences Llc | A novel tolypocladium album strain |
RU2679051C1 (en) * | 2018-02-16 | 2019-02-05 | Федеральное государственное учреждение Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук | STREPTOMYCES HYGROSCOPICUS VKM Ac-2737D STRAIN - RAPAMYCIN ANTIBIOTIC PRODUCER AND METHOD FOR INCREASING PRODUCTIVITY THEREOF |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE295870C (en) * | ||||
US3878047A (en) * | 1973-02-02 | 1975-04-15 | Upjohn Co | Process for production of AT-125 |
US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
US4215199A (en) * | 1978-06-05 | 1980-07-29 | Sandoz Ltd. | Antibiotic production |
DD295870A5 (en) * | 1988-10-11 | 1991-11-14 | Arzneimittelwerk Dresden Gmbh,De | METHOD FOR MICROBIAL RECOVERY OF CYCLOSPORINS |
DD298276A5 (en) * | 1988-10-11 | 1992-02-13 | Institut Fuer Mikrobiologie Und Experimentelle Therapie,De | PROCESS FOR THE PREPARATION OF CYCLOSPORIN A |
HU201577B (en) * | 1988-12-20 | 1990-11-28 | Gyogyszerkutato Intezet | Process for producing cyclosporin antibiotics |
EP0568698B1 (en) * | 1991-01-25 | 1997-09-10 | Fujisawa Pharmaceutical Co., Ltd. | Process for producing cyclosporin a and/or c |
ATE127528T1 (en) * | 1991-04-06 | 1995-09-15 | Dresden Arzneimittel | METHOD FOR THE FERMENTATIVE PRODUCTION AND ISOLATION OF CYCLOSPORIN A AND NEW CYCLOSPORIN-PRODUCING STRAINS. |
-
1992
- 1992-12-30 FI FI925940A patent/FI92334C/en not_active IP Right Cessation
-
1993
- 1993-02-22 US US08/020,545 patent/US5409816A/en not_active Expired - Fee Related
- 1993-12-29 RU RU95114383A patent/RU2112807C1/en not_active IP Right Cessation
- 1993-12-29 AU AU57014/94A patent/AU674723B2/en not_active Ceased
- 1993-12-29 AT AT94902795T patent/ATE196655T1/en not_active IP Right Cessation
- 1993-12-29 PL PL93309613A patent/PL177023B1/en not_active IP Right Cessation
- 1993-12-29 JP JP51571394A patent/JP3530531B2/en not_active Expired - Fee Related
- 1993-12-29 PT PT94902795T patent/PT677116E/en unknown
- 1993-12-29 SG SG1996005777A patent/SG49072A1/en unknown
- 1993-12-29 DE DE69329500T patent/DE69329500T2/en not_active Expired - Fee Related
- 1993-12-29 HU HU9501951A patent/HU217683B/en not_active IP Right Cessation
- 1993-12-29 CA CA002152963A patent/CA2152963C/en not_active Expired - Fee Related
- 1993-12-29 ES ES94902795T patent/ES2150980T3/en not_active Expired - Lifetime
- 1993-12-29 WO PCT/FI1993/000568 patent/WO1994016091A1/en active IP Right Grant
- 1993-12-29 KR KR1019950702677A patent/KR100283503B1/en not_active IP Right Cessation
- 1993-12-29 DK DK94902795T patent/DK0677116T3/en active
- 1993-12-29 EP EP94902795A patent/EP0677116B1/en not_active Expired - Lifetime
-
1994
- 1994-11-16 EE EE9400184A patent/EE03114B1/en not_active IP Right Cessation
-
1998
- 1998-12-23 HK HK98115143A patent/HK1014035A1/en not_active IP Right Cessation
-
2000
- 2000-12-22 GR GR20000402825T patent/GR3035139T3/en not_active IP Right Cessation
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