RU95114383A - METHOD FOR PRODUCING IMMUNO DEPRESSANTS AND A NEW MICROBIOLOGICAL VIEW FOR ITS IMPLEMENTATION - Google Patents

METHOD FOR PRODUCING IMMUNO DEPRESSANTS AND A NEW MICROBIOLOGICAL VIEW FOR ITS IMPLEMENTATION

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Publication number
RU95114383A
RU95114383A RU95114383/13A RU95114383A RU95114383A RU 95114383 A RU95114383 A RU 95114383A RU 95114383/13 A RU95114383/13 A RU 95114383/13A RU 95114383 A RU95114383 A RU 95114383A RU 95114383 A RU95114383 A RU 95114383A
Authority
RU
Russia
Prior art keywords
cbs
tolypocladium
cyclosporin
strain
depressants
Prior art date
Application number
RU95114383/13A
Other languages
Russian (ru)
Other versions
RU2112807C1 (en
Inventor
Юхани Лунделл
Аниа Копио
Тимо КОРПЕЛА
Матти Анкело
Original Assignee
Леирас Ой
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI925940A external-priority patent/FI92334C/en
Application filed by Леирас Ой filed Critical Леирас Ой
Publication of RU95114383A publication Critical patent/RU95114383A/en
Application granted granted Critical
Publication of RU2112807C1 publication Critical patent/RU2112807C1/en

Links

Claims (6)

1. Способ производства иммунодепрессантов, а именно циклоспорина А, включающий культивирование нового штамма вида Tolypocladium, селекционированного из штамма Tolypocladium sp. LeAЗ CBS 630.92 и имеющего все идентифицирующие характеристики Le AЗ CBS 630.92 в питательной среде до получения упомянутого циклоспорина. А, и, если необходимо, очистку и выделение произведенного циклоспорина А.1. A method for the production of immunosuppressants, namely cyclosporin A, comprising cultivating a new strain of the species Tolypocladium, selected from a strain of Tolypocladium sp. LeAZ CBS 630.92 and having all the identifying characteristics of Le AZ CBS 630.92 in a nutrient medium to obtain the aforementioned cyclosporin. A, and, if necessary, purification and isolation of the produced cyclosporin A. 2. Способ по п. 1, где культивирование производят аэробно при 20 - 30oС.2. The method according to p. 1, where the cultivation is performed aerobically at 20 - 30 o C. 3. Способ по п. 1, где штамм представляет собой Tolypocladium sp. LeАЗ CBS 630.92. 3. The method of claim 1, wherein the strain is Tolypocladium sp. LeAZ CBS 630.92. 4. Способ по п. 1, где питательная среда содержит мелассу и соевую муку. 4. The method according to p. 1, where the nutrient medium contains molasses and soy flour. 5. Способ по п. 1, где питательная среда содержит сахарозу и муку из хлопковых семян. 5. The method according to p. 1, where the nutrient medium contains sucrose and flour from cotton seeds. 6. Биологически чистая культура штамма Tolypocladium sp. Le АЗ CBS 630.92, продуцирующая иммунодепрессант циклоспорин А. 6. Biologically pure culture of the strain Tolypocladium sp. Le AZ CBS 630.92 producing the immunosuppressant cyclosporin A.
RU95114383A 1992-12-30 1993-12-29 Method of preparing immunodepressant cyclosporin a and a strain tolypocladium species cbs 630 92 producing cyclosporin a RU2112807C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI925940 1992-12-30
FI925940A FI92334C (en) 1992-12-30 1992-12-30 Process for producing cyclosporins and new Tolypocladium strain useful in the process
PCT/FI1993/000568 WO1994016091A1 (en) 1992-12-30 1993-12-29 A process for producing immunosuppressives and a novel microbial species to be employed therein

Publications (2)

Publication Number Publication Date
RU95114383A true RU95114383A (en) 1997-07-20
RU2112807C1 RU2112807C1 (en) 1998-06-10

Family

ID=8536483

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95114383A RU2112807C1 (en) 1992-12-30 1993-12-29 Method of preparing immunodepressant cyclosporin a and a strain tolypocladium species cbs 630 92 producing cyclosporin a

Country Status (20)

Country Link
US (1) US5409816A (en)
EP (1) EP0677116B1 (en)
JP (1) JP3530531B2 (en)
KR (1) KR100283503B1 (en)
AT (1) ATE196655T1 (en)
AU (1) AU674723B2 (en)
CA (1) CA2152963C (en)
DE (1) DE69329500T2 (en)
DK (1) DK0677116T3 (en)
EE (1) EE03114B1 (en)
ES (1) ES2150980T3 (en)
FI (1) FI92334C (en)
GR (1) GR3035139T3 (en)
HK (1) HK1014035A1 (en)
HU (1) HU217683B (en)
PL (1) PL177023B1 (en)
PT (1) PT677116E (en)
RU (1) RU2112807C1 (en)
SG (1) SG49072A1 (en)
WO (1) WO1994016091A1 (en)

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EP0725076B1 (en) * 1995-02-01 2001-06-06 National Research Development Corporation of India A process for the preparation of cyclosporin A from tolypocladium species
KR100360675B1 (en) * 1995-02-28 2003-01-14 내셔널 리서어치 디벨럽먼트 코포레이션 How to make cyclosporine A
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
HU223054B1 (en) * 1997-03-25 2004-03-01 BIOGAL Gyógyszergyár Rt. Purification process for producing high purity ciklosporin a
US6423233B1 (en) * 2000-08-15 2002-07-23 Biogal Gyogyszergyar Rt. Purification process
KR100496929B1 (en) * 1997-03-25 2005-09-30 테바 기오기스제르갸르 레스즈베니타르사사그 Method of Purifying Cyclosporin
ATE423130T1 (en) 1997-10-08 2009-03-15 Isotechnika Inc DEUTERATED CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
WO2000040219A1 (en) 1998-12-30 2000-07-13 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosporin
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
CN1406124A (en) * 2000-01-20 2003-03-26 巴斯利尔药物股份公司 Nasally administrable cyclic peptide compositions
US7176001B1 (en) * 2000-02-29 2007-02-13 Biocon Limited Manufacture and purification of cyclosporin A
CA2461740C (en) 2001-10-19 2013-02-12 Isotechnika Inc. Synthesis of cyclosporin analogs
US7862552B2 (en) * 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
EP2151450A1 (en) * 2008-07-29 2010-02-10 Sandoz AG Method for processing microbiologically produced cyclic oligopeptides
WO2019067423A1 (en) * 2017-09-29 2019-04-04 Valent Biosciences Llc A novel tolypocladium album strain
RU2679051C1 (en) * 2018-02-16 2019-02-05 Федеральное государственное учреждение Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук STREPTOMYCES HYGROSCOPICUS VKM Ac-2737D STRAIN - RAPAMYCIN ANTIBIOTIC PRODUCER AND METHOD FOR INCREASING PRODUCTIVITY THEREOF

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DE295870C (en) *
US3878047A (en) * 1973-02-02 1975-04-15 Upjohn Co Process for production of AT-125
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
DD295870A5 (en) * 1988-10-11 1991-11-14 Arzneimittelwerk Dresden Gmbh,De METHOD FOR MICROBIAL RECOVERY OF CYCLOSPORINS
DD298276A5 (en) * 1988-10-11 1992-02-13 Institut Fuer Mikrobiologie Und Experimentelle Therapie,De PROCESS FOR THE PREPARATION OF CYCLOSPORIN A
HU201577B (en) * 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
EP0568698B1 (en) * 1991-01-25 1997-09-10 Fujisawa Pharmaceutical Co., Ltd. Process for producing cyclosporin a and/or c
ATE127528T1 (en) * 1991-04-06 1995-09-15 Dresden Arzneimittel METHOD FOR THE FERMENTATIVE PRODUCTION AND ISOLATION OF CYCLOSPORIN A AND NEW CYCLOSPORIN-PRODUCING STRAINS.

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