RU95113187A - METHOD FOR DETERMINING SYSTEM INFLAMMATION - Google Patents

METHOD FOR DETERMINING SYSTEM INFLAMMATION

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Publication number
RU95113187A
RU95113187A RU95113187/14A RU95113187A RU95113187A RU 95113187 A RU95113187 A RU 95113187A RU 95113187/14 A RU95113187/14 A RU 95113187/14A RU 95113187 A RU95113187 A RU 95113187A RU 95113187 A RU95113187 A RU 95113187A
Authority
RU
Russia
Prior art keywords
blood
sample
fibrinogen
blood sample
level
Prior art date
Application number
RU95113187/14A
Other languages
Russian (ru)
Other versions
RU2122212C1 (en
Inventor
С.Балл Брайнан
А.Левин Роберт
С.Вордло Стефен
Original Assignee
С.Балл Брайнан
А.Левин Роберт
С.Вордло Стефен
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/348,345 external-priority patent/US5506145A/en
Application filed by С.Балл Брайнан, А.Левин Роберт, С.Вордло Стефен filed Critical С.Балл Брайнан
Publication of RU95113187A publication Critical patent/RU95113187A/en
Application granted granted Critical
Publication of RU2122212C1 publication Critical patent/RU2122212C1/en

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Claims (7)

1. Способ определения степени системного воспаления в образце несвертываемой цельной крови млекопитающего-донора, отличающийся тем, что включает следующие стадии: измерение количества фибриноген/фибрин в указанном образце крови, определение значения гематокрита или гемоглобина образца крови и вычисление числа 1, которое является показателем степени системного воспаления, при решении уравнения
r а(f) + в(h) + с,
где f - измеренный уровень фибриноген/фибрин в образце
h - определенные значения гематокрита или гелоглобина в образце;
а, b и с - эмпирически полученные константы.1. A method for determining the degree of systemic inflammation in a non-clotting whole blood sample of a mammalian donor, characterized in that it includes the following steps: measuring the amount of fibrinogen / fibrin in said blood sample, determining the value of the hematocrit or hemoglobin of the blood sample and calculating the number 1, which is an indicator of the degree systemic inflammation, when solving the equation
r a (f) + b (h) + c,
where f is the measured level of fibrinogen / fibrin in the sample
h — specific hematocrit or geloglobin values in the sample;
a, b, and c are empirically derived constants. 2. Способ по п. 1, отличающийся тем, что образцом крови является образец несвертываемой крови человека-донора, h - определенное значение гемокрита в oбpaзцe; а = 0,154, b = 1,667, и с = 42, по которому уровень фибриноген/фибрин выражен в мг/дл образца крови и значение гематокрита выражено к объемный процент от эритроцитарной массы в образце крови. 2. The method according to p. 1, characterized in that the blood sample is a sample of non-clotted blood of a human donor, h is a specific value of hemocrit in a sample; a = 0.154, b = 1.677, and c = 42, according to which the fibrinogen / fibrin level is expressed in mg / dl of the blood sample and the hematocrit value is expressed as a volume percentage of the erythrocyte mass in the blood sample. 3. Способ по п. 2, отличающийся тем, что образцом крови является центрифугируемый образец крови человека. 3. The method according to p. 2, characterized in that the blood sample is a centrifuged human blood sample. 4. Способ по п. 1, отличающийся тем, что образцом крови является образец несвертываемой крови человека-донора, h - определенное значение гемоглобина в образец, а = 0,154, b = 5,001 и с = 42, по которому уровень фибриноген/фибрин выражен в мг/дл образца крови, и значение гемоглобина выражено в г/ди образца крови. 4. The method according to p. 1, characterized in that the blood sample is a sample of non-clotted blood of a human donor, h is the specific value of hemoglobin in the sample, a = 0.154, b = 5.001 and c = 42, according to which the level of fibrinogen / fibrin is expressed in mg / dl of the blood sample, and the hemoglobin value is expressed in g / d of the blood sample. 5. Способ по п. 4, отличающийся тем, что образцом крови является центрифугируемый образец крови человека. 5. The method according to p. 4, characterized in that the blood sample is a centrifuged human blood sample. 6. Способ по п. 1, отличающийся тем, что константы а, b и с определяют путем сравнения показателя реакции оседания эритроцитов крови (РОЭ) при анализе консенсуса у множества доноров, показателя уровня фибриногена крови и показателя С-реактивного белка крови (С - реактивная кровь) по отношению к крови человека у доноров, подтверждающих в широком диапазоне симптомы воспаления, причем указанное сравнение проводят с показателем уровня фибриноген/фибрин и со значением гематокрита по отношению к крови человека той же самой популяции доноров. 6. The method according to p. 1, characterized in that the constants a, b and c are determined by comparing the rate of erythrocyte sedimentation of blood (ROE) when analyzing the consensus of many donors, the level of blood fibrinogen and the rate of C-reactive blood protein (C - reactive blood) in relation to human blood in donors who confirm a wide range of inflammation symptoms, and this comparison is made with an indicator of fibrinogen / fibrin level and with a hematocrit value in relation to human blood of the same donor population. 7. Способ по п. 1, отличающийся тем, что константы а, b и с определяют путем сравнения показателя реакции оседания эритроцитов крови (РОЭ) при анализе консенсуса у множества доноров: показателя уровня фибриногена крови и показателя С-реактивного белка крови (С-реактивная кровь) по отношению к крови человека у доноров, подтверждающих в широком диапазоне симптомы воспаления, причем указанное сравнение проводят с показателем уровня фибриноген/фибрин и значением гемоглобина по отношению к крови человека той же самой популяции доноров. 7. The method according to p. 1, characterized in that the constants a, b and c are determined by comparing the rate of erythrocyte sedimentation of blood (ROE) when analyzing the consensus of many donors: an indicator of the level of blood fibrinogen and an indicator of C-reactive blood protein (C- reactive blood) in relation to human blood in donors, confirming a wide range of symptoms of inflammation, moreover, this comparison is carried out with an indicator of fibrinogen / fibrin level and hemoglobin value in relation to human blood of the same donor population.
RU95113187A 1994-12-02 1995-07-14 Method for determining systemic inflammation RU2122212C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/348,345 1994-12-02
US08/348,345 US5506145A (en) 1994-12-02 1994-12-02 Determination of an individual's inflammation index from whole blood fibrinogen and hematocrit or hemoglobin measurements

Publications (2)

Publication Number Publication Date
RU95113187A true RU95113187A (en) 1998-01-10
RU2122212C1 RU2122212C1 (en) 1998-11-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU95113187A RU2122212C1 (en) 1994-12-02 1995-07-14 Method for determining systemic inflammation

Country Status (10)

Country Link
US (1) US5506145A (en)
EP (1) EP0715170A2 (en)
JP (1) JPH08166389A (en)
CN (1) CN1123914A (en)
AU (1) AU690972B2 (en)
CA (1) CA2149580A1 (en)
FI (1) FI955784A (en)
NO (1) NO954897L (en)
RU (1) RU2122212C1 (en)
TW (1) TW321721B (en)

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