RU95112842A - ANTITUMER COMPOSITION CONTAINING TAXANA DERIVATIVES - Google Patents

ANTITUMER COMPOSITION CONTAINING TAXANA DERIVATIVES

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Publication number
RU95112842A
RU95112842A RU95112842/14A RU95112842A RU95112842A RU 95112842 A RU95112842 A RU 95112842A RU 95112842/14 A RU95112842/14 A RU 95112842/14A RU 95112842 A RU95112842 A RU 95112842A RU 95112842 A RU95112842 A RU 95112842A
Authority
RU
Russia
Prior art keywords
composition according
derivatives
epidophyllotoxins
antimetabolites
procarbazine
Prior art date
Application number
RU95112842/14A
Other languages
Russian (ru)
Other versions
RU2131250C1 (en
Inventor
Биссери Мари-Кристин
Original Assignee
Рон-Пуленк Роре С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9213525A external-priority patent/FR2697752B1/en
Application filed by Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А.
Publication of RU95112842A publication Critical patent/RU95112842A/en
Application granted granted Critical
Publication of RU2131250C1 publication Critical patent/RU2131250C1/en

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Claims (13)

1. Противоопухолевая композиция, содержащая комбинации производных таксана с веществом, терапевтически пригодным для лечения опухолевых заболеваний.1. An antitumor composition containing combinations of taxane derivatives with a substance therapeutically suitable for the treatment of tumor diseases. 2. Композиция по п. 1, отличающаяся тем, что в качестве терапевтически пригодного вещества применяют алкилирующие агенты, антиметаболиты, веретенные токсины, эпидофиллотоксины, антибиотики, ферменты, ингибиторы топоизомеразы, различные соединения, выбираемые среди прокарбазина, митоксантрона, или координационные комплексы платины, модификаторы биологического ответа или ингибиторами факторов роста. 2. The composition according to p. 1, characterized in that alkylating agents, antimetabolites, spindle toxins, epidophyllotoxins, antibiotics, enzymes, topoisomerase inhibitors, various compounds selected from procarbazine, mitoxantrone, or platinum coordination complexes, modifiers are used as therapeutically suitable substances. biological response or growth factor inhibitors. 3. Композиция по п. 2, отличающаяся тем, что алкилирующие агенты выбирают среди циклофосфамина, ифосфамида, мелфалана, гексаметилмеламина, тиотепы или дикарбазина. 3. The composition according to p. 2, characterized in that the alkylating agents are selected from cyclophosphamine, ifosfamide, melphalan, hexamethylmelamine, thiotepa or dicarbazine. 4. Композиция по п. 2, отличающаяся тем, что антиметаболиты выбирают среди 5-фторурацила, цитарабина и аналогов фолиевой кислоты, выбираемых из метотрексата, идатрексата и триметрексата. 4. The composition according to p. 2, characterized in that the antimetabolites are selected among 5-fluorouracil, cytarabine and folic acid analogues selected from methotrexate, idatrexate and trimerexate. 5. Композиция по п. 2, отличающаяся тем, что веретенные токсины выбирают среди алкалоидов барвинка, из синтетических или полусинтетических аналогов, или эстрамустина или таксоидов. 5. The composition according to p. 2, characterized in that the spindle toxins are selected among vinca alkaloids, from synthetic or semi-synthetic analogues, or estramustine or taxoids. 6. Композиция по п. 2, отличающаяся тем, что эпидофиллотоксины выбирают среди этопозида и тенипозида. 6. The composition according to p. 2, characterized in that the epidophyllotoxins are selected among etoposide and teniposide. 7. Композиция по п. 2, отличающаяся тем, что антибиотики выбирают среди даунорубицина, доксорубицина, блеомицина или митомицина. 7. The composition according to p. 2, characterized in that the antibiotics are selected among daunorubicin, doxorubicin, bleomycin or mitomycin. 8. Композиция по п. 2, отличающаяся тем, что ферментом является 1-аспарагин. 8. The composition according to p. 2, characterized in that the enzyme is 1-asparagine. 9. Композиция по п. 2, отличающаяся тем, что ингибиторы топоизомеразы выбирают среди камфотецина и его производных, в свою очередь выбираемых среди СРТ-11 и топотекана и производных пиридобензоиндола. 9. The composition according to p. 2, characterized in that the topoisomerase inhibitors are selected among camphothecin and its derivatives, which in turn are selected from CPT-11 and topotecan and pyridobenzoindole derivatives. 10. Композиция по п. 2, отличающаяся тем, что различные соединения выбирают среди прокарбазина, митоксантрона и координационных комплексов платины, выбираемых среди цисплатины и карбоплатины. 10. The composition according to p. 2, characterized in that the various compounds are selected among procarbazine, mitoxantrone and platinum coordination complexes selected among cisplatin and carboplatin. 11. Композиция по п. 2, отличающаяся тем, что модификаторы биологического ответа и ингибиторы факторов роста выбирают среди интерферонов и интерлейкинов. 11. The composition according to p. 2, characterized in that the biological response modifiers and growth factor inhibitors are selected among interferons and interleukins. 12. Композиция по любому из пп. 1 - 11, отличающаяся тем, что она содержит дополнительно факторы роста кроветворного типа. 12. The composition according to any one of paragraphs. 1 to 11, characterized in that it additionally contains hematopoietic growth factors. 13. Композиция по любому из пп. 1 - 12, отличающаяся тем, что она содержит 10-90 мас.% производных таксана. 13. The composition according to any one of paragraphs. 1 to 12, characterized in that it contains 10-90 wt.% Derivatives of taxane.
RU95112842A 1992-11-10 1993-11-08 Antitumor composition containing taxane derivatives RU2131250C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9213525 1992-11-10
FR9213525A FR2697752B1 (en) 1992-11-10 1992-11-10 Antitumor compositions containing taxane derivatives.
PCT/FR1993/001096 WO1994010995A1 (en) 1992-11-10 1993-11-08 Antitumour compositions containing taxane derivatives

Publications (2)

Publication Number Publication Date
RU95112842A true RU95112842A (en) 1997-10-10
RU2131250C1 RU2131250C1 (en) 1999-06-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU95112842A RU2131250C1 (en) 1992-11-10 1993-11-08 Antitumor composition containing taxane derivatives

Country Status (25)

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US (13) US5728687A (en)
EP (4) EP1093811A1 (en)
JP (1) JP3974938B2 (en)
KR (2) KR100334051B1 (en)
AT (2) ATE205083T1 (en)
AU (1) AU680845B2 (en)
CA (1) CA2149055C (en)
CZ (2) CZ288033B6 (en)
DE (2) DE69318033T2 (en)
DK (2) DK0667771T3 (en)
ES (2) ES2114620T3 (en)
FI (1) FI952248A (en)
FR (1) FR2697752B1 (en)
GR (2) GR3026666T3 (en)
HU (1) HU223773B1 (en)
MX (1) MX9306924A (en)
NO (1) NO315027B1 (en)
NZ (1) NZ257585A (en)
PL (1) PL173951B1 (en)
PT (1) PT827745E (en)
RU (1) RU2131250C1 (en)
SK (1) SK282867B6 (en)
TW (1) TW386877B (en)
WO (1) WO1994010995A1 (en)
ZA (1) ZA938182B (en)

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