RU95108596A - PROTEIN Possessing the ability to inhibit collagen stimulated platelet aggregation and prevent interaction between collagen and vwf, the method of obtaining it - Google Patents
PROTEIN Possessing the ability to inhibit collagen stimulated platelet aggregation and prevent interaction between collagen and vwf, the method of obtaining itInfo
- Publication number
- RU95108596A RU95108596A RU95108596/13A RU95108596A RU95108596A RU 95108596 A RU95108596 A RU 95108596A RU 95108596/13 A RU95108596/13 A RU 95108596/13A RU 95108596 A RU95108596 A RU 95108596A RU 95108596 A RU95108596 A RU 95108596A
- Authority
- RU
- Russia
- Prior art keywords
- collagen
- protein
- vwf
- platelet aggregation
- ability
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title claims 7
- 108010035532 Collagen Proteins 0.000 title claims 7
- 229960005188 collagen Drugs 0.000 title claims 7
- 229920001436 collagen Polymers 0.000 title claims 7
- 102000004169 proteins and genes Human genes 0.000 title claims 7
- 108090000623 proteins and genes Proteins 0.000 title claims 7
- 208000010110 Spontaneous Platelet Aggregation Diseases 0.000 title claims 4
- 230000003993 interaction Effects 0.000 title claims 3
- 102100019017 VWF Human genes 0.000 claims 5
- 108010047303 von Willebrand Factor Proteins 0.000 claims 5
- 229960001134 von Willebrand factor Drugs 0.000 claims 5
- 239000000969 carrier Substances 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 241000237902 Hirudo medicinalis Species 0.000 claims 2
- 210000003296 Saliva Anatomy 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000001124 Body Fluids Anatomy 0.000 claims 1
- 241000545744 Hirudinea Species 0.000 claims 1
- 108010058683 Immobilized Proteins Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000002429 anti-coagulation Effects 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001962 electrophoresis Methods 0.000 claims 1
- 239000003527 fibrinolytic agent Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 229960000103 thrombolytic agents Drugs 0.000 claims 1
Claims (9)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93110528.2 | 1993-07-01 | ||
EP93110528 | 1993-07-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU95108596A true RU95108596A (en) | 1999-01-10 |
RU2160280C2 RU2160280C2 (en) | 2000-12-10 |
Family
ID=8213032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU95108596/13A RU2160280C2 (en) | 1993-07-01 | 1994-06-28 | PROTEIN CAPABLE ON INHIBITING COLLAGEN STIMULATED AGGREGATION OF THROMBOCYTES AND PREVENTING INTERACTION BETWEEN COLLAGEN AND vWF, METHOD OF PREPARING THEREOF, PHARMACOLOGICAL COMPOSITION BASED THEREON |
Country Status (22)
Country | Link |
---|---|
US (1) | US5710131A (en) |
EP (1) | EP0662088B1 (en) |
JP (1) | JP3742429B2 (en) |
KR (2) | KR100445309B1 (en) |
CN (1) | CN1134451C (en) |
AT (1) | ATE210679T1 (en) |
AU (1) | AU680929B2 (en) |
CA (1) | CA2143416C (en) |
CZ (1) | CZ287472B6 (en) |
DE (1) | DE69429419T2 (en) |
DK (1) | DK0662088T3 (en) |
ES (1) | ES2169080T3 (en) |
HU (1) | HU214580B (en) |
NO (1) | NO320150B1 (en) |
PL (1) | PL180752B1 (en) |
PT (1) | PT662088E (en) |
RU (1) | RU2160280C2 (en) |
SK (1) | SK282961B6 (en) |
TW (1) | TW281678B (en) |
UA (1) | UA41332C2 (en) |
WO (1) | WO1995001375A1 (en) |
ZA (1) | ZA944738B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2153760B1 (en) * | 1998-11-25 | 2001-07-01 | Univ Barcelona Autonoma | METALOCARBOXIPEPTIDASAS INHIBITORS AS A FIBRINOLITIC AGENT. |
CZ301524B6 (en) * | 1999-03-18 | 2010-03-31 | Merck Patent Gmbh | Polypeptide isolated from H. medicinalis, process for its preparation and use, pharmaceutical composition, polynucleotide, expression vector, host cell, antibody and use thereof |
SK15762001A3 (en) | 1999-05-07 | 2002-04-04 | Merck Patent Gmbh | Recombinant platelet collagen receptor glycoprotein vi and its pharmaceutical use |
MY128992A (en) | 2000-08-25 | 2007-03-30 | Merck Patent Gmbh | Saratin for inhibiting platelet adhesion to collagen |
GB0031448D0 (en) * | 2000-12-22 | 2001-02-07 | Leuven K U Res & Dev | Inhibition of the vWF-collagen interaction by anti-human vWF monoclonal antibody (82D6A3) results in abolition of in vivo arterial platelet thrombus formation |
CA2578046A1 (en) * | 2004-09-07 | 2006-03-16 | Archemix Corp. | Aptamer medicinal chemistry |
JP2008512098A (en) | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | Aptamers against von Willebrand factor and their use as treatments for thrombotic diseases |
US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
US20060286548A1 (en) * | 2005-06-16 | 2006-12-21 | Gregory Liposky | Method of making recombinant human antibodies for use in biosensor technology |
US20110034396A1 (en) * | 2005-09-28 | 2011-02-10 | Biovascular, Inc. | Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions |
JP2009510105A (en) * | 2005-09-28 | 2009-03-12 | バイオバスキュラー インコーポレーティッド | Methods and compositions for inhibiting platelet and cell adhesion, cell migration, and inflammation |
TWI391143B (en) * | 2005-11-04 | 2013-04-01 | Otsuka Pharma Co Ltd | Platelet aggregation inhibitor composition |
US20080015145A1 (en) * | 2006-07-11 | 2008-01-17 | Maria Gyongyossy-Issa | Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions |
US20090203766A1 (en) * | 2007-06-01 | 2009-08-13 | Archemix Corp. | vWF aptamer formulations and methods for use |
EP2316465A1 (en) * | 2009-10-15 | 2011-05-04 | Centre National De La Recherche Scientifique | Use of extract of leeches' saliva as anti-bacterial agent for the manufacture of different compositons |
WO2012104866A1 (en) | 2011-01-31 | 2012-08-09 | Council Of Scientific & Industrial Research | Chiral 1-(4-methylphenylmethyl)-5-oxo-{n-[(3-t-butoxycarbonyl- aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5238919A (en) * | 1986-05-30 | 1993-08-24 | Scipps Clinic And Research Foundation | Peptides that inhibit von Willebrand Factor binding to the platelet SPIB receptor |
ES2070116T3 (en) * | 1986-05-30 | 1995-06-01 | Scripps Research Inst | PEPTIDES THAT INHIBIT THE UNION OF THE VON WILLEBRAND FACTOR. |
US5256559A (en) * | 1988-03-04 | 1993-10-26 | Biogen, Inc. | Methods and compositions for inhibiting platelet aggregation |
IL86856A0 (en) * | 1988-06-24 | 1988-11-30 | Yissum Res Dev Co | Bovine xa factor and pharmaceutical compositions containing the same |
JPH04503660A (en) * | 1988-12-05 | 1992-07-02 | バイオジェン インコーポレイテッド | Method and composition for inhibiting platelet aggregation |
CA2008116C (en) * | 1989-02-23 | 2001-11-20 | Thomas Weller | Glycine derivatives |
CA2052486A1 (en) * | 1990-10-09 | 1992-04-10 | Thomas M. Connolly | Protein for inhibiting collagen-stimulated platelet aggregation |
GB9022040D0 (en) * | 1990-10-10 | 1990-11-21 | Biopharm Ltd | Platelet adhesion inhibitor |
US5342830A (en) * | 1990-11-16 | 1994-08-30 | Cor Therapeutics, Inc. | Antithrombosis agents |
-
1994
- 1994-06-28 PT PT94923690T patent/PT662088E/en unknown
- 1994-06-28 EP EP94923690A patent/EP0662088B1/en not_active Expired - Lifetime
- 1994-06-28 DK DK94923690T patent/DK0662088T3/en active
- 1994-06-28 HU HU9500613A patent/HU214580B/en not_active IP Right Cessation
- 1994-06-28 AT AT94923690T patent/ATE210679T1/en not_active IP Right Cessation
- 1994-06-28 KR KR1019950700766A patent/KR100445309B1/en not_active IP Right Cessation
- 1994-06-28 SK SK270-95A patent/SK282961B6/en unknown
- 1994-06-28 PL PL94307726A patent/PL180752B1/en not_active IP Right Cessation
- 1994-06-28 AU AU73836/94A patent/AU680929B2/en not_active Ceased
- 1994-06-28 UA UA95028198A patent/UA41332C2/en unknown
- 1994-06-28 RU RU95108596/13A patent/RU2160280C2/en not_active IP Right Cessation
- 1994-06-28 CA CA002143416A patent/CA2143416C/en not_active Expired - Fee Related
- 1994-06-28 ES ES94923690T patent/ES2169080T3/en not_active Expired - Lifetime
- 1994-06-28 WO PCT/EP1994/002087 patent/WO1995001375A1/en active Application Filing
- 1994-06-28 DE DE69429419T patent/DE69429419T2/en not_active Expired - Fee Related
- 1994-06-28 KR KR10-2004-7002282A patent/KR100455639B1/en not_active IP Right Cessation
- 1994-06-28 JP JP50326095A patent/JP3742429B2/en not_active Expired - Fee Related
- 1994-06-28 CZ CZ1995528A patent/CZ287472B6/en not_active IP Right Cessation
- 1994-06-28 CN CNB941904229A patent/CN1134451C/en not_active Expired - Fee Related
- 1994-06-28 US US08/392,970 patent/US5710131A/en not_active Expired - Fee Related
- 1994-06-30 ZA ZA944738A patent/ZA944738B/en unknown
- 1994-07-18 TW TW083106615A patent/TW281678B/zh active
-
1995
- 1995-02-27 NO NO19950732A patent/NO320150B1/en unknown
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