RU95102462A - Method of avermectin complex preparing for construction of preparations for prophylaxis and complex treatment of diseases caused by endo- and ectoparasites in animals, preparations based on thereof - Google Patents

Method of avermectin complex preparing for construction of preparations for prophylaxis and complex treatment of diseases caused by endo- and ectoparasites in animals, preparations based on thereof

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Publication number
RU95102462A
RU95102462A RU95102462/13A RU95102462A RU95102462A RU 95102462 A RU95102462 A RU 95102462A RU 95102462/13 A RU95102462/13 A RU 95102462/13A RU 95102462 A RU95102462 A RU 95102462A RU 95102462 A RU95102462 A RU 95102462A
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RU
Russia
Prior art keywords
complex
avermectin
treatment
preparations
streptomyces avermitilis
Prior art date
Application number
RU95102462/13A
Other languages
Russian (ru)
Other versions
RU2054848C1 (en
Inventor
В.А. Дриняев
Е.Б. Кругляк
Л.П. Головкина
В.А. Мосин
Д.И. Удавлиев
Г.Н. Тенькова
Г.А. Таланов
В.А. Юркив
В.Т. Лисовенко
Original Assignee
Товарищество с ограниченной ответственностью Научно-производственное объединение "Фармбиомед"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Товарищество с ограниченной ответственностью Научно-производственное объединение "Фармбиомед" filed Critical Товарищество с ограниченной ответственностью Научно-производственное объединение "Фармбиомед"
Priority to RU95102462/13A priority Critical patent/RU2054848C1/en
Application granted granted Critical
Publication of RU2054848C1 publication Critical patent/RU2054848C1/en
Publication of RU95102462A publication Critical patent/RU95102462A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fodder In General (AREA)

Abstract

FIELD: veterinary medicine. SUBSTANCE: method involves culturing the producer Streptomyces avermitilis "ВНИИСХМ-54". Additionally, before culturing clones were selected by TLC method that produce avermectin complex at amount 1800 mcg/ml (not less). Vegetative sowing material is grown for two stages, cultured for 4-8 days. Mycelial biomass is separated, milled, wetted and complex is extracted with water-mixing solvent followed by purification of ethanol extract of avermectin complex by exposition at -35 ± 5 C for 24-72 h, treatment with activated carbon and ion-exchange resins at room temperature. Preparation for treatment has 1.8-83 g/l highly purified avermectin complex isolated from Streptomyces avermitilis "ВНИИСХМ-54" mycelium in ethanol and pharmacologically acceptable carrier and used in different medicinal forms. EFFECT: improved method of preparing, enhanced effectiveness of complex

Claims (1)

Изобретение относится к ветеринарной медицине, к способу получения авермектинового комплекса путем культивирования продуцента Streptomyces avermitilis ВНИИСХМ-54, при этом дополнительно перед культивированием методом ТСХ отбирают клоны, продуцирующие авермектиновый комплекс в количестве не ниже 1800 мкг/мл и проводят выращивание вегетативного посевного материала в два этапа, культивируют 4 - 8 сут, отделяют мицелиальную биомассу, дробят, увляжняют, экстрагируют из нее комплекс растворителями, смешивающимся с водой, с последующей очисткой этанольного экстракта авермектинового комплекса выдерживания его при минус 35 ± 5oС в течение 24 - 72 ч с последующей обработкой его активированным углем и ионообменными смолами при комнатной температуре. Препарат авермектинового комплекса для профилактики и комплексного лечения заболеваний, вызванных эндо- и эктопаразитами животных в качестве активного начала содержит 1,8 - 83 г/л высокоочищенного авермектинового комплекса из мицелия Streptomyces avermitilis ВНИИСХМ-54 в этаноле и фармакологически приемлемый носитель в различных лекарственных формах.The invention relates to veterinary medicine, to a method for producing an avermectin complex by cultivating the producer of Streptomyces avermitilis VNIISXM-54, in addition, clones producing the avermectin complex in an amount of at least 1800 μg / ml are selected before cultivation by TLC and the vegetative seed is grown in two stages , cultivated for 4-8 days, the mycelial biomass is separated, crushed, settled, the complex is extracted from it with solvents miscible with water, followed by purification of ethanol about the extract of the avermectin complex holding it at minus 35 ± 5 ° C for 24 to 72 hours, followed by treatment with activated carbon and ion-exchange resins at room temperature. The preparation of the avermectin complex for the prevention and complex treatment of diseases caused by endo- and ectoparasites of animals contains 1.8 - 83 g / l of the highly purified avermectin complex from the Streptomyces avermitilis VNIISXM-54 mycelium in ethanol and a pharmacologically acceptable carrier in various dosage forms as an active principle.
RU95102462/13A 1995-02-28 1995-02-28 METHOD FOR OBTAINING AVERMECTINE COMPLEX AND DRUG OF AVERMECTINE COMPLEX FOR PREVENTION AND COMPLEX TREATMENT OF DISEASES CAUSED BY ENDO AND ECOPARASITES OF ANIMALS RU2054848C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU95102462/13A RU2054848C1 (en) 1995-02-28 1995-02-28 METHOD FOR OBTAINING AVERMECTINE COMPLEX AND DRUG OF AVERMECTINE COMPLEX FOR PREVENTION AND COMPLEX TREATMENT OF DISEASES CAUSED BY ENDO AND ECOPARASITES OF ANIMALS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU95102462/13A RU2054848C1 (en) 1995-02-28 1995-02-28 METHOD FOR OBTAINING AVERMECTINE COMPLEX AND DRUG OF AVERMECTINE COMPLEX FOR PREVENTION AND COMPLEX TREATMENT OF DISEASES CAUSED BY ENDO AND ECOPARASITES OF ANIMALS

Publications (2)

Publication Number Publication Date
RU2054848C1 RU2054848C1 (en) 1996-02-20
RU95102462A true RU95102462A (en) 1997-03-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU95102462/13A RU2054848C1 (en) 1995-02-28 1995-02-28 METHOD FOR OBTAINING AVERMECTINE COMPLEX AND DRUG OF AVERMECTINE COMPLEX FOR PREVENTION AND COMPLEX TREATMENT OF DISEASES CAUSED BY ENDO AND ECOPARASITES OF ANIMALS

Country Status (1)

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RU (1) RU2054848C1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056939A1 (en) * 1997-06-09 1998-12-17 Vladimir Alexandrovich Mosin Streptomyces avermitilis strain, method for separating avermectin complexes and preparations for protecting plants and animals

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2162699C1 (en) * 2000-02-14 2001-02-10 Закрытое Акционерное Общество "Нита-Фарм" Aqueous-dispersed medicinal form of ivermectin for treatment of ecto- and endoparasitosis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056939A1 (en) * 1997-06-09 1998-12-17 Vladimir Alexandrovich Mosin Streptomyces avermitilis strain, method for separating avermectin complexes and preparations for protecting plants and animals

Also Published As

Publication number Publication date
RU2054848C1 (en) 1996-02-20

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