RU94040361A - AEROSOL PHARMACEUTICAL COMPOSITION, SPRAYER FOR DELIVERY OF THE COMPOSITION, DOSAGE INHALATOR, METHOD FOR TREATING RESPIRATORY DISEASES, METHOD FOR PRODUCING THE COMPOSITION - Google Patents
AEROSOL PHARMACEUTICAL COMPOSITION, SPRAYER FOR DELIVERY OF THE COMPOSITION, DOSAGE INHALATOR, METHOD FOR TREATING RESPIRATORY DISEASES, METHOD FOR PRODUCING THE COMPOSITIONInfo
- Publication number
- RU94040361A RU94040361A RU94040361/14A RU94040361A RU94040361A RU 94040361 A RU94040361 A RU 94040361A RU 94040361/14 A RU94040361/14 A RU 94040361/14A RU 94040361 A RU94040361 A RU 94040361A RU 94040361 A RU94040361 A RU 94040361A
- Authority
- RU
- Russia
- Prior art keywords
- composition according
- composition
- propellant
- paragraphs
- beclomethasone dipropionate
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 27
- 206010038683 Respiratory disease Diseases 0.000 title claims 2
- 239000000443 aerosol Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 12
- 229940038482 BECLOMETHASONE DIPROPIONATE MONOHYDRATE Drugs 0.000 claims 8
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone dipropionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims 8
- 229950000210 beclometasone dipropionate Drugs 0.000 claims 8
- 239000003380 propellant Substances 0.000 claims 8
- 239000008249 pharmaceutical aerosol Substances 0.000 claims 6
- NBVXSUQYWXRMNV-UHFFFAOYSA-N Fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 claims 4
- 239000000969 carrier Substances 0.000 claims 3
- 238000002425 crystallisation Methods 0.000 claims 3
- 230000005712 crystallization Effects 0.000 claims 3
- 150000004682 monohydrates Chemical class 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-Heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims 2
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-Tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims 2
- NDAUXUAQIAJITI-UHFFFAOYSA-N Salbutamol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 2
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 229960002052 salbutamol Drugs 0.000 claims 2
- 229960004017 salmeterol Drugs 0.000 claims 2
- 229940071648 Metered Dose Inhaler Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (20)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9202519.6 | 1992-02-06 | ||
GB929202519A GB9202519D0 (en) | 1992-02-06 | 1992-02-06 | Medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
RU94040361A true RU94040361A (en) | 1998-02-10 |
RU2120285C1 RU2120285C1 (en) | 1998-10-20 |
Family
ID=10709929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94040361A RU2120285C1 (en) | 1992-02-06 | 1993-02-02 | Aerosol pharmaceutic composition, bottle for storage and delivery of aerosol pharmaceutic composition, method of treatment of respiratory diseases, composition preparation method |
Country Status (31)
Country | Link |
---|---|
US (2) | US5695744A (en) |
EP (1) | EP0625046B1 (en) |
JP (1) | JP3675474B2 (en) |
CN (1) | CN1048394C (en) |
AP (1) | AP419A (en) |
AT (1) | ATE157875T1 (en) |
AU (1) | AU667074B2 (en) |
BG (1) | BG61862B1 (en) |
CA (1) | CA2128688A1 (en) |
CZ (1) | CZ281942B6 (en) |
DE (1) | DE69313825T2 (en) |
DK (1) | DK0625046T3 (en) |
ES (1) | ES2106360T3 (en) |
GB (1) | GB9202519D0 (en) |
GE (1) | GEP19991820B (en) |
GR (1) | GR3025363T3 (en) |
HK (1) | HK1009588A1 (en) |
HU (2) | HUT68986A (en) |
IL (1) | IL104628A (en) |
IS (1) | IS1622B (en) |
MX (1) | MX9300620A (en) |
MY (1) | MY108748A (en) |
NO (1) | NO306453B1 (en) |
NZ (1) | NZ246889A (en) |
OA (1) | OA10091A (en) |
RO (1) | RO118173B1 (en) |
RU (1) | RU2120285C1 (en) |
SK (1) | SK279291B6 (en) |
TW (1) | TW299234B (en) |
WO (1) | WO1993015741A1 (en) |
ZA (1) | ZA93800B (en) |
Families Citing this family (59)
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US5919435A (en) * | 1990-11-09 | 1999-07-06 | Glaxo Group Limited | Aerosol formulation containing a particulate medicament |
IL104068A (en) | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant |
AU663905B2 (en) | 1991-12-12 | 1995-10-26 | Glaxo Group Limited | Medicaments |
US7101534B1 (en) | 1991-12-18 | 2006-09-05 | 3M Innovative Properties Company | Suspension aerosol formulations |
ATE150296T1 (en) | 1991-12-18 | 1997-04-15 | Minnesota Mining & Mfg | AEROSOL COMPOSITIONS FOR MEDICINAL SUSPENSIONS |
US7105152B1 (en) | 1991-12-18 | 2006-09-12 | 3M Innovative Properties Company | Suspension aerosol formulations |
US5833950A (en) * | 1992-07-31 | 1998-11-10 | Glaxo Group Limited | Aerosol formulations containing beclomethasone dipropionate-1, 1, 1, 2-tetrafluoroethane solvate |
GB9404945D0 (en) | 1994-03-15 | 1994-04-27 | Glaxo Group Ltd | Pharmaceutical composition |
CZ288146B6 (en) * | 1994-12-22 | 2001-05-16 | Astra Ab | Pharmaceutical aerosol preparation, process of its preparation and use |
US6013245A (en) * | 1995-01-26 | 2000-01-11 | Glaxo Group Limited | Aerosol formulation containing beclomethasone dipropionate and 1,1,1,2,3,3,3-heptafluoro-n-propane as propellant |
US5874481A (en) * | 1995-06-07 | 1999-02-23 | Alliance Pharmaceutical Corp. | Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents |
EE03509B2 (en) | 1995-06-27 | 2015-02-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ethanol containing medicinal compositions for generating propellantfree aerosols |
HU224224B1 (en) * | 1997-01-14 | 2005-06-28 | Lts Lohmann Therapie-Systeme Gmbh | Expandable gastro-retentive therapeutic system with controlled active substance release in the gastro-intestinal tract |
US6054487A (en) * | 1997-03-18 | 2000-04-25 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
CN1269722A (en) * | 1997-03-18 | 2000-10-11 | Basf公司 | Method and composition for modulating responsiveness to corticosteroids |
US5891420A (en) * | 1997-04-21 | 1999-04-06 | Aeropharm Technology Limited | Environmentally safe triancinolone acetonide aerosol formulations for oral inhalation |
US6129905A (en) * | 1997-04-21 | 2000-10-10 | Aeropharm Technology, Inc. | Aerosol formulations containing a sugar as a dispersant |
US5891419A (en) * | 1997-04-21 | 1999-04-06 | Aeropharm Technology Limited | Environmentally safe flunisolide aerosol formulations for oral inhalation |
US6433040B1 (en) * | 1997-09-29 | 2002-08-13 | Inhale Therapeutic Systems, Inc. | Stabilized bioactive preparations and methods of use |
US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6946117B1 (en) * | 1997-09-29 | 2005-09-20 | Nektar Therapeutics | Stabilized preparations for use in nebulizers |
US6598603B1 (en) * | 1997-12-31 | 2003-07-29 | Astra Aktiebolag | Method for treating respiratory diseases |
US6086376A (en) * | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
TWI243687B (en) * | 1998-04-21 | 2005-11-21 | Teijin Ltd | Pharmaceutical composition for application to mucosa |
US6136294C1 (en) * | 1998-09-22 | 2002-09-24 | Aeropharm Technology Inc | Amino acid stabilized medical aerosol formulation |
US6458338B1 (en) | 1998-09-22 | 2002-10-01 | Aeropharm Technology Incorporated | Amino acid stabilized medicinal aerosol formulations |
IT1303692B1 (en) * | 1998-11-03 | 2001-02-23 | Chiesi Farma Spa | PROCEDURE FOR THE PREPARATION OF SUSPENSIONS OF PARTICLES OF DRUGS TO BE ADMINISTERED BY INHALATION. |
US6261539B1 (en) * | 1998-12-10 | 2001-07-17 | Akwete Adjei | Medicinal aerosol formulation |
US7074388B2 (en) * | 1998-12-10 | 2006-07-11 | Kos Life Science, Inc. | Water stabilized medicinal aerosol formulation |
US20060171899A1 (en) * | 1998-12-10 | 2006-08-03 | Akwete Adjei | Water-stabilized aerosol formulation system and method of making |
US6540982B1 (en) | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
US6540983B1 (en) | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
US6548049B1 (en) | 2000-05-01 | 2003-04-15 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
US6565833B1 (en) | 2000-05-01 | 2003-05-20 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
US6447750B1 (en) | 2000-05-01 | 2002-09-10 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
DK1280520T4 (en) | 2000-05-10 | 2018-06-25 | Novartis Ag | Phospholipid based powders for drug delivery |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
AU2001247123A1 (en) * | 2000-07-19 | 2002-02-05 | Aeropharm Technology, Inc. | A medicinal aerosol formulation |
CA2417973A1 (en) * | 2000-08-04 | 2002-02-14 | Longwood Pharmaceutical Research, Inc. | Formulations of mometasone and a bronchodilator for pulmonary administration |
US6455028B1 (en) | 2001-04-23 | 2002-09-24 | Pharmascience | Ipratropium formulation for pulmonary inhalation |
GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
EP1458360B1 (en) | 2001-12-19 | 2011-05-11 | Novartis AG | Pulmonary delivery of aminoglycosides |
EP1415647A1 (en) * | 2002-10-23 | 2004-05-06 | CHIESI FARMACEUTICI S.p.A. | "Long-acting beta-2 agonists ultrafine formulations" |
AU2007231727B2 (en) * | 2002-09-03 | 2010-12-16 | Kos Life Sciences, Inc. | Water stabilized medicinal aerosol formulation |
ATE390125T1 (en) * | 2003-03-20 | 2008-04-15 | Boehringer Ingelheim Pharma | FORMULATION FOR A MESSAGE INHALER USING HYDRO-FLUORO-ALKANES AS PROpellants |
US20040191176A1 (en) * | 2003-03-28 | 2004-09-30 | Kaplan Leonard W | Formulations for treatment of pulmonary disorders |
JP5053635B2 (en) * | 2003-08-29 | 2012-10-17 | グラクソ グループ リミテッド | Medical metered dose inhaler and method related thereto |
AR041873A1 (en) * | 2003-10-30 | 2005-06-01 | Pablo Cassara Srl Lab | A PHARMACEUTICAL FORMULATION IN ADEQUATE AEROSOL FOR ORAL OR NASAL INHALATION CONTAINING GLUCOCORTICOIDS IN A STABLE SOLUTION TO STORAGE; A METHOD FOR STABILIZING FORMULATIONS AND USE OF A STABILIZING AGENT |
US20050238632A1 (en) * | 2004-04-23 | 2005-10-27 | Alburty David S | Propellant formulations |
ES2391563T5 (en) * | 2004-07-02 | 2022-10-26 | Boehringer Ingelheim Int | Aerosol suspension formulations with TG 227 ea as propellant |
BRPI0606736A2 (en) | 2005-02-11 | 2009-07-21 | Argenta Discovery Ltd | combination of methylxanthine compounds and steroids to treat chronic respiratory diseases |
US9084799B2 (en) | 2005-02-11 | 2015-07-21 | Pulmagen Therapeutics (Synergy) Limited | Inhaled combination therapy |
DE102006017320A1 (en) | 2006-04-11 | 2007-10-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosol suspension formulations with TG 227 ea or TG 134 a as propellant |
US20070286814A1 (en) * | 2006-06-12 | 2007-12-13 | Medispray Laboratories Pvt. Ltd. | Stable aerosol pharmaceutical formulations |
EP2425820B1 (en) | 2007-02-11 | 2015-04-08 | MAP Pharmaceuticals Inc | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
RU2504402C1 (en) * | 2012-11-20 | 2014-01-20 | Шолекс Девелопмент Гмбх | Inhalation formulation in form of aerosol for treating bronchial asthma and chronic obstructive pulmonary disease |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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FI63672C (en) * | 1980-05-19 | 1983-08-10 | Orion Yhtymae Oy | FOERFARANDE FOER FRAMSTAELLNING AV EN BLANDNING AV BEKLOMETASONDIPROPIONAT OCH TRIKLORFLUORMETAN ELLER DIKLORDIFLUORMETAN |
KR890000664B1 (en) * | 1981-10-19 | 1989-03-22 | 바리 안소니 뉴우샘 | Preparation method for micronised be clomethasone dispropionate mono-hydrate |
GB2107715B (en) * | 1981-10-19 | 1985-11-13 | Glaxo Group Ltd | Micronised beclomethasone dipropionate monohydrate and powder inhalation compositions containing it |
GB8432063D0 (en) * | 1984-12-19 | 1985-01-30 | Riker Laboratories Inc | Physically modified steroids |
DE69105212T2 (en) * | 1990-10-18 | 1995-03-23 | Minnesota Mining & Mfg | AEROSOL PREPARATION CONTAINING BECLOMETASON 17.21 DIPROPIONATE. |
-
1992
- 1992-02-06 GB GB929202519A patent/GB9202519D0/en active Pending
-
1993
- 1993-02-02 ES ES93917355T patent/ES2106360T3/en not_active Expired - Lifetime
- 1993-02-02 DK DK93917355.5T patent/DK0625046T3/en active
- 1993-02-02 CA CA002128688A patent/CA2128688A1/en not_active Abandoned
- 1993-02-02 RU RU94040361A patent/RU2120285C1/en active
- 1993-02-02 RO RO94-01278A patent/RO118173B1/en unknown
- 1993-02-02 NZ NZ246889A patent/NZ246889A/en unknown
- 1993-02-02 JP JP51372993A patent/JP3675474B2/en not_active Expired - Fee Related
- 1993-02-02 DE DE69313825T patent/DE69313825T2/en not_active Expired - Lifetime
- 1993-02-02 CZ CZ941846A patent/CZ281942B6/en not_active IP Right Cessation
- 1993-02-02 SK SK924-94A patent/SK279291B6/en unknown
- 1993-02-02 WO PCT/EP1993/000223 patent/WO1993015741A1/en active IP Right Grant
- 1993-02-02 AU AU34525/93A patent/AU667074B2/en not_active Ceased
- 1993-02-02 EP EP93917355A patent/EP0625046B1/en not_active Expired - Lifetime
- 1993-02-02 US US08/256,294 patent/US5695744A/en not_active Expired - Lifetime
- 1993-02-02 AT AT93917355T patent/ATE157875T1/en active
- 1993-02-02 HU HU9402301A patent/HUT68986A/en unknown
- 1993-02-04 MX MX9300620A patent/MX9300620A/en active IP Right Grant
- 1993-02-05 CN CN93102529A patent/CN1048394C/en not_active Expired - Fee Related
- 1993-02-05 AP APAP/P/1993/000484A patent/AP419A/en active
- 1993-02-05 TW TW082100772A patent/TW299234B/zh active
- 1993-02-05 MY MYPI93000190A patent/MY108748A/en unknown
- 1993-02-05 ZA ZA93800A patent/ZA93800B/en unknown
- 1993-02-05 IL IL10462893A patent/IL104628A/en not_active IP Right Cessation
- 1993-02-05 IS IS3974A patent/IS1622B/en unknown
- 1993-02-06 GE GEAP19932600A patent/GEP19991820B/en unknown
-
1994
- 1994-07-08 BG BG98897A patent/BG61862B1/en unknown
- 1994-08-04 OA OA60548A patent/OA10091A/en unknown
- 1994-08-05 NO NO942923A patent/NO306453B1/en unknown
-
1995
- 1995-06-02 US US08/458,241 patent/US5688782A/en not_active Expired - Lifetime
- 1995-06-09 HU HU95P/P00177P patent/HU211696A9/en unknown
-
1997
- 1997-11-12 GR GR970403005T patent/GR3025363T3/en unknown
-
1998
- 1998-09-01 HK HK98110346A patent/HK1009588A1/en not_active IP Right Cessation
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