RU94039629A - Stimulating agent for human bone marrow cell growth
- Google Patents
Stimulating agent for human bone marrow cell growth
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Publication number
RU94039629A
RU94039629ARU94039629/14ARU94039629ARU94039629ARU 94039629 ARU94039629 ARU 94039629ARU 94039629/14 ARU94039629/14 ARU 94039629/14ARU 94039629 ARU94039629 ARU 94039629ARU 94039629 ARU94039629 ARU 94039629A
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Application filed by В.Е. Жемчугов, А.Г. Румянцев, А.В. ЗурочкаfiledCriticalВ.Е. Жемчугов
Priority to RU94039629ApriorityCriticalpatent/RU2136308C1/en
Publication of RU94039629ApublicationCriticalpatent/RU94039629A/en
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Publication of RU2136308C1publicationCriticalpatent/RU2136308C1/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Abstract
FIELD: medicine, hematology, immunology, oncology. SUBSTANCE: method involves the use of synthetic polypeptide for stimulation of bone marrow cells of the following amino acid sequence: lysine-glycine-proline-leucine-theronine-norleucine-norleucine- alanine-serine-histidine-tyrosine-lysine-glycine-histidine-cys- -teine-proline by the formula Lys-Gly-Pro-Leu-Thr-Nle-Nle-Ala- -Ser-His-Tyr-Lys-Gln-His-Cys-Pro that corresponds the site of natural molecule "ГМ-КСФ". Synthesis of proposed peptide is carried out by solid-phase method. EFFECT: enhanced effectiveness of agent, improved method of synthesis.
Claims (1)
Изобретение относится к экспериментальной и клинической гематологии, иммунологии, онкологии, радиационной медицине и может быть использован для лечения депрессий кроветворения, связанных с развитием нарушений кроветворения при химиотерапии опухолей, трансплантации костного мозга, других органов и тканей, лучевой терапии, радиационных поражениях; для терапии агранулоцитозов и миелодиспластических состояний различного генеза (первичных - генетически обусловленных, вторичных - вследствие воспалительных заболеваний, тяжелых травм, ожогов, вирусных инфекций, в том числе СПИДа.) Используют в качестве стимулятора роста костно мозговых клеток синтетический полипептид, включающий последовательность аминокислот лизин-глицин-пролин-лейцин-треонин-норлейцин-норлейцин-аланинсерин-гистидин-тирозин-лизин-глицин-гистидин-цистеин-пролин по формуле LYS GLY PRO LEY THR NLE NLE ALA SER HIS TYR LYS GLN HIS CYS PRO., соответствующую участку молекулы природного ГМ-КСФ. Синтез предлагаемого пептида осуществляют твердофазным методом.The invention relates to experimental and clinical hematology, immunology, oncology, radiation medicine and can be used to treat hematopoiesis depression associated with the development of hematopoiesis during chemotherapy of tumors, transplantation of bone marrow, other organs and tissues, radiation therapy, radiation injuries; for the treatment of agranulocytosis and myelodysplastic states of various origins (primary - genetically determined, secondary - due to inflammatory diseases, serious injuries, burns, viral infections, including AIDS.) A synthetic polypeptide comprising a sequence of lysine amino acids is used as a stimulator of bone marrow cell growth glycine-proline-leucine-threonine-norleucine-norleucine-alaninserin-histidine-tyrosine-lysine-glycine-histidine-cysteine-proline according to the formula LYS GLY PRO LEY THR NLE NLE ALA SER HIS TYR LYS GLN HIS CYS PRO., resp. favoring regions of the molecules of natural GM-CSF. The synthesis of the proposed peptide is carried out by the solid-phase method.
RU94039629A1994-11-161994-11-16Growth stimulating agent for human bone marrow cells
RU2136308C1
(en)
Pharmaceutical compositions, methods of leukosis treatment, method of stem cell level increase, antagonist c-kit-ligand, nonsense nucleic acid, method of melanoma treatment, method of transfection enhancement, method of gene transfer, method of peripheral blood level increase, method of platelet level increase, method of biological function modification, method of anemia treatment, method of bone marrow implantation improvement, method of bone marrow recovery acceleration, method of leukopenia treatment