RU94039629A - Stimulating agent for human bone marrow cell growth - Google Patents

Stimulating agent for human bone marrow cell growth

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Publication number
RU94039629A
RU94039629A RU94039629/14A RU94039629A RU94039629A RU 94039629 A RU94039629 A RU 94039629A RU 94039629/14 A RU94039629/14 A RU 94039629/14A RU 94039629 A RU94039629 A RU 94039629A RU 94039629 A RU94039629 A RU 94039629A
Authority
RU
Russia
Prior art keywords
bone marrow
norleucine
histidine
glycine
proline
Prior art date
Application number
RU94039629/14A
Other languages
Russian (ru)
Other versions
RU2136308C1 (en
Inventor
В.Е. Жемчугов
А.Г. Румянцев
Е.Б. Владимирская
Ю.И. Кондрашин
А.В. Зурочка
Original Assignee
В.Е. Жемчугов
А.Г. Румянцев
А.В. Зурочка
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by В.Е. Жемчугов, А.Г. Румянцев, А.В. Зурочка filed Critical В.Е. Жемчугов
Priority to RU94039629A priority Critical patent/RU2136308C1/en
Publication of RU94039629A publication Critical patent/RU94039629A/en
Application granted granted Critical
Publication of RU2136308C1 publication Critical patent/RU2136308C1/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

FIELD: medicine, hematology, immunology, oncology. SUBSTANCE: method involves the use of synthetic polypeptide for stimulation of bone marrow cells of the following amino acid sequence: lysine-glycine-proline-leucine-theronine-norleucine-norleucine- alanine-serine-histidine-tyrosine-lysine-glycine-histidine-cys- -teine-proline by the formula Lys-Gly-Pro-Leu-Thr-Nle-Nle-Ala- -Ser-His-Tyr-Lys-Gln-His-Cys-Pro that corresponds the site of natural molecule "ГМ-КСФ". Synthesis of proposed peptide is carried out by solid-phase method. EFFECT: enhanced effectiveness of agent, improved method of synthesis.

Claims (1)

Изобретение относится к экспериментальной и клинической гематологии, иммунологии, онкологии, радиационной медицине и может быть использован для лечения депрессий кроветворения, связанных с развитием нарушений кроветворения при химиотерапии опухолей, трансплантации костного мозга, других органов и тканей, лучевой терапии, радиационных поражениях; для терапии агранулоцитозов и миелодиспластических состояний различного генеза (первичных - генетически обусловленных, вторичных - вследствие воспалительных заболеваний, тяжелых травм, ожогов, вирусных инфекций, в том числе СПИДа.) Используют в качестве стимулятора роста костно мозговых клеток синтетический полипептид, включающий последовательность аминокислот лизин-глицин-пролин-лейцин-треонин-норлейцин-норлейцин-аланинсерин-гистидин-тирозин-лизин-глицин-гистидин-цистеин-пролин по формуле LYS GLY PRO LEY THR NLE NLE ALA SER HIS TYR LYS GLN HIS CYS PRO., соответствующую участку молекулы природного ГМ-КСФ. Синтез предлагаемого пептида осуществляют твердофазным методом.The invention relates to experimental and clinical hematology, immunology, oncology, radiation medicine and can be used to treat hematopoiesis depression associated with the development of hematopoiesis during chemotherapy of tumors, transplantation of bone marrow, other organs and tissues, radiation therapy, radiation injuries; for the treatment of agranulocytosis and myelodysplastic states of various origins (primary - genetically determined, secondary - due to inflammatory diseases, serious injuries, burns, viral infections, including AIDS.) A synthetic polypeptide comprising a sequence of lysine amino acids is used as a stimulator of bone marrow cell growth glycine-proline-leucine-threonine-norleucine-norleucine-alaninserin-histidine-tyrosine-lysine-glycine-histidine-cysteine-proline according to the formula LYS GLY PRO LEY THR NLE NLE ALA SER HIS TYR LYS GLN HIS CYS PRO., resp. favoring regions of the molecules of natural GM-CSF. The synthesis of the proposed peptide is carried out by the solid-phase method.
RU94039629A 1994-11-16 1994-11-16 Growth stimulating agent for human bone marrow cells RU2136308C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU94039629A RU2136308C1 (en) 1994-11-16 1994-11-16 Growth stimulating agent for human bone marrow cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU94039629A RU2136308C1 (en) 1994-11-16 1994-11-16 Growth stimulating agent for human bone marrow cells

Publications (2)

Publication Number Publication Date
RU94039629A true RU94039629A (en) 1996-09-20
RU2136308C1 RU2136308C1 (en) 1999-09-10

Family

ID=20161997

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94039629A RU2136308C1 (en) 1994-11-16 1994-11-16 Growth stimulating agent for human bone marrow cells

Country Status (1)

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RU (1) RU2136308C1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1504033A2 (en) 2002-05-03 2005-02-09 Millenium Biologix Inc. Connective tissue stimulating peptides
RU2455020C2 (en) * 2010-07-13 2012-07-10 Учреждение Российской академии наук Тюменский научный центр Сибирского отделения РАН (ТюмНЦ СО РАН) Method of increasing repair activity

Also Published As

Publication number Publication date
RU2136308C1 (en) 1999-09-10

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