RU94032103A - PEPTIDES, PHARMACEUTICAL COMPOSITION, VACCINE, CONJUGAT, TREATMENT METHODS AND IDENTIFICATION - Google Patents

PEPTIDES, PHARMACEUTICAL COMPOSITION, VACCINE, CONJUGAT, TREATMENT METHODS AND IDENTIFICATION

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Publication number
RU94032103A
RU94032103A RU94032103/04A RU94032103A RU94032103A RU 94032103 A RU94032103 A RU 94032103A RU 94032103/04 A RU94032103/04 A RU 94032103/04A RU 94032103 A RU94032103 A RU 94032103A RU 94032103 A RU94032103 A RU 94032103A
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RU
Russia
Prior art keywords
peptides
nvu
conjugat
vaccine
identification
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Application number
RU94032103/04A
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Russian (ru)
Inventor
В. Чизари Фрэнсис
Феррари Карло
Пенна Амалиа
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Дзе Скриппс Рисерч Инститьют
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Publication of RU94032103A publication Critical patent/RU94032103A/en

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Claims (1)

Пептиды используют для определения эпитопов, которые стимулируют НZА-ограниченную, цитотоксическую Т-лимфоцитную активность против антигенов вируса гепатита В. Эти пептиды получают из участков НВУ нуклеокапсида, оболочки, полимеразы и транскрипционного трансактиваторного Х протеина, и они особенно пригодны для лечения или предотвращения НВУ инфекции, включая способы стимуляции иммунной реакции хронически инфицированных индивидуумов в ответ на НВУ антигены. Фармацевтические композиции и вакцины против гепатита В, которые включают пептиды и физиологически приемлемые носители, можно использовать вместе в другими НВУ вакцинами для создания более эффективного иммунитета против этой болезни. Представлены способы идентификации индивидуумов, которые особенно предрасположены к развитию хронической НВУ инфекции, и которых можно лечить CTZ пептидами.Peptides are used to determine epitopes that stimulate HZA-limited, cytotoxic T-lymphocyte activity against hepatitis B antigens. These peptides are obtained from the NVU sections of the nucleocapsid, envelope, polymerase, and transcriptional X protein, and they are especially suitable for treating or preventing the NVU infection , including ways to stimulate the immune response of chronically infected individuals in response to NVU antigens. Pharmaceutical compositions and hepatitis B vaccines, which include peptides and physiologically acceptable carriers, can be used together with other NVU vaccines to create more effective immunity against this disease. Presents methods for identifying individuals who are particularly prone to developing chronic NWU infection and who can be treated with CTZ peptides.
RU94032103/04A 1991-08-26 1992-08-26 PEPTIDES, PHARMACEUTICAL COMPOSITION, VACCINE, CONJUGAT, TREATMENT METHODS AND IDENTIFICATION RU94032103A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US749540 1991-08-26

Publications (1)

Publication Number Publication Date
RU94032103A true RU94032103A (en) 1995-09-27

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