RU94022484A - BICYCLIC COMPLEXES BETA-LACTAM / PARAMAINOBENZOIC ACID, CEPHALOSPORINES AND METHODS FOR THEIR RECEIVING - Google Patents

BICYCLIC COMPLEXES BETA-LACTAM / PARAMAINOBENZOIC ACID, CEPHALOSPORINES AND METHODS FOR THEIR RECEIVING

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Publication number
RU94022484A
RU94022484A RU94022484/04A RU94022484A RU94022484A RU 94022484 A RU94022484 A RU 94022484A RU 94022484/04 A RU94022484/04 A RU 94022484/04A RU 94022484 A RU94022484 A RU 94022484A RU 94022484 A RU94022484 A RU 94022484A
Authority
RU
Russia
Prior art keywords
complexes
paramainobenzoic
cephalosporines
lactam
bicyclic
Prior art date
Application number
RU94022484/04A
Other languages
Russian (ru)
Other versions
RU2134265C1 (en
Inventor
Годде Амос Джейн
Майкл Инделикато Джозеф
Элейн Пасини Кэрол
Мэри Ройцель Сьюзн
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/084,651 external-priority patent/US5412094A/en
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of RU94022484A publication Critical patent/RU94022484A/en
Application granted granted Critical
Publication of RU2134265C1 publication Critical patent/RU2134265C1/en

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Claims (1)

Изобретение относится к комплексам общей формулы
Figure 00000001

где X - хлор, водород, винил или -СН<Mv>3<D>, Z - CH<Mv>2<D>, S или О, n = 0 - 5, Y - фенил или 1,4-циклогексадиен-1-ил, R<Mv>1<D> и R<Mv>2<D> - водород или оксигруппа, при условии, что оба R<Mv>1<D> и R<Mv>2<D> не являются водородом, R<Mv>3<D> - -COO-, -СОО(C<Mv>1<D> - C<Mv>4<D>-алкил), NO<Mv>2<D> или -C-R<Mv>4<D>, где R<Mv>4<D> - C<Mv>1<D> - C<Mv>4<D>-алкил.The invention relates to complexes of the general formula
Figure 00000001

where X is chlorine, hydrogen, vinyl or -CH <Mv> 3 <D>, Z is CH <Mv> 2 <D>, S or O, n = 0-5, Y is phenyl or 1,4-cyclohexadiene 1-yl, R <Mv> 1 <D> and R <Mv> 2 <D> are hydrogen or hydroxy, provided that both R <Mv> 1 <D> and R <Mv> 2 <D> are not hydrogen, R <Mv> 3 <D> - -COO-, -СОО (C <Mv> 1 <D> - C <Mv> 4 <D> -alkyl), NO <Mv> 2 <D> or -CR <Mv> 4 <D>, where R <Mv> 4 <D> is C <Mv> 1 <D> is C <Mv> 4 <D> is alkyl.
RU94022484A 1993-06-28 1994-06-27 Bicyclic complexes beta-lactam/hydroxybenzoic acid, methods of beta-lactams synthesis RU2134265C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/084,651 1993-06-28
US08/084,651 US5412094A (en) 1993-06-28 1993-06-28 Bicyclic beta-lactam/paraben complexes

Publications (2)

Publication Number Publication Date
RU94022484A true RU94022484A (en) 1996-03-20
RU2134265C1 RU2134265C1 (en) 1999-08-10

Family

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Family Applications (1)

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RU94022484A RU2134265C1 (en) 1993-06-28 1994-06-27 Bicyclic complexes beta-lactam/hydroxybenzoic acid, methods of beta-lactams synthesis

Country Status (25)

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US (1) US5412094A (en)
EP (1) EP0637587B1 (en)
JP (1) JPH0748383A (en)
KR (1) KR950000707A (en)
CN (1) CN1044246C (en)
AT (1) ATE159942T1 (en)
AU (1) AU674226B2 (en)
BR (1) BR9402561A (en)
CA (1) CA2126401A1 (en)
CO (1) CO4230098A1 (en)
CZ (1) CZ285452B6 (en)
DE (1) DE69406607T2 (en)
DK (1) DK0637587T3 (en)
ES (1) ES2110185T3 (en)
FI (1) FI106460B (en)
GR (1) GR3025563T3 (en)
HU (1) HU219484B (en)
IL (1) IL110103A (en)
NO (1) NO305480B1 (en)
NZ (1) NZ260791A (en)
PE (1) PE57294A1 (en)
PL (1) PL177317B1 (en)
RU (1) RU2134265C1 (en)
YU (1) YU40694A (en)
ZA (1) ZA944376B (en)

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US6001996A (en) * 1995-05-11 1999-12-14 Eli Lilly And Company Complexes of cephalosporins and carbacephalosporins with parabens
US20090088443A1 (en) * 2002-02-15 2009-04-02 Julius Remenar Novel crystalline forms of conazoles and methods of making and using the same
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
AU2003213719A1 (en) * 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
US20070059356A1 (en) * 2002-05-31 2007-03-15 Almarsson Oern Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
AU2003243699B2 (en) * 2002-06-21 2009-01-15 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US8183290B2 (en) * 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
WO2011054741A2 (en) * 2009-11-06 2011-05-12 Basf Se Crystalline complexes of 4-hydroxy benzoic acid and selected pesticides
CN105997931A (en) * 2016-07-19 2016-10-12 南京正宽医药科技有限公司 Cefixime capsules and preparation method thereof
CN113845529B (en) * 2021-10-15 2024-02-27 东南大学 Cefalexin eutectic compound and preparation method thereof

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US3531481A (en) * 1969-04-21 1970-09-29 Lilly Co Eli Method for manufacture of crystalline cephalosporin
GB1510794A (en) * 1974-08-06 1978-05-17 Univ Kingston 1-oxacephems and intermediates therefor
AT363594B (en) * 1978-02-01 1981-08-10 Biochemie Gmbh METHOD FOR PRODUCING A NEW FORMAMIDE COMPLEX OF 7-BETA- (D-2-AMINO-2-PHENYLACETAMIDO) -3-METHYLCEPH-3-EMCARBONIC ACID
PH21016A (en) * 1982-07-23 1987-06-30 Meiji Seika Kaisha 2-alkyl-1-oxa-dethia-cephalosporin derivatives and process for producing said compound
US4782144A (en) * 1987-09-14 1988-11-01 Eli Lilly And Company 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof
DD273634A5 (en) * 1987-10-06 1989-11-22 ����@�����@�����@����k�� PROCESS FOR PREPARING A CRYSTALLINE MONOHYDRATE OF A 1-CARBACEPHALOSPORIN
KR0135979B1 (en) * 1988-05-13 1998-04-25 메리 앤 터커 Method for recovery of anti-biotics from mother liquors
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
US4977257A (en) * 1988-11-14 1990-12-11 Eli Lilly And Company DMF solvates of a β-lactam antibiotic
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