RU94019425A - DERIVATIVES OF IZATINOKSIMA, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT - Google Patents
DERIVATIVES OF IZATINOKSIMA, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENTInfo
- Publication number
- RU94019425A RU94019425A RU94019425/04A RU94019425A RU94019425A RU 94019425 A RU94019425 A RU 94019425A RU 94019425/04 A RU94019425/04 A RU 94019425/04A RU 94019425 A RU94019425 A RU 94019425A RU 94019425 A RU94019425 A RU 94019425A
- Authority
- RU
- Russia
- Prior art keywords
- cyclic
- branched
- alkyl
- izatinoksima
- derivatives
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- XRMDCWJNPDVAFI-UHFFFAOYSA-N 2,2,6,6-tetramethyl-1-oxopiperidin-1-ium-4-ol Chemical compound CC1(C)CC(O)CC(C)(C)[N+]1=O XRMDCWJNPDVAFI-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 229960002989 Glutamic Acid Drugs 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 108010011562 aspartic acid receptor Proteins 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Claims (1)
где R4 и R5 независимо представляют собой водород, галоген CF3, CN, NO2 или группу SO2NR1R2, где R1 - водород или C1 - 6 алкил, который может быть разветвленным или циклическим, R2 - водород или C1 - 6 алкил, который может быть нормальным, разветвленным или циклическим, или где R1 или R2 вместе образуют группу -(CH2)n-A-(CH2)m-, где A - 0, S, CH2 или NRI, где RI -H, C1 - 6 алкил, который может быть нормальным, разветвленным или циклическим, n = 0, 1, 2, 3, 4, 5; m = 0, 1, 2, 3, 4, 5; Q - NOH или 0; Z = 0, S, N - RI I,
where R 4 and R 5 independently represent hydrogen, halogen CF 3 , CN, NO 2 or a group of SO 2 NR 1 R 2 , where R 1 is hydrogen or C 1 - 6 alkyl, which may be branched or cyclic, R 2 - hydrogen or C 1 - 6 alkyl, which may be normal, branched or cyclic, or where R 1 or R 2 together form the group - (CH 2 ) n - A - (CH 2 ) m -, where A - 0, S, CH 2 or NR I , where R I is H, C 1 is 6 alkyl, which can be normal, branched or cyclic, n = 0, 1, 2, 3, 4, 5; m = 0, 1, 2, 3, 4, 5; Q is NOH or 0; Z = 0, S, N - R I I ,
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75116591A | 1991-08-28 | 1991-08-28 | |
| US751165 | 1991-08-28 | ||
| US751,165 | 1991-08-28 | ||
| US83185192A | 1992-02-05 | 1992-02-05 | |
| US831,851 | 1992-02-05 | ||
| US831851 | 1992-02-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94019425A true RU94019425A (en) | 1995-09-27 |
| RU2114827C1 RU2114827C1 (en) | 1998-07-10 |
Family
ID=27115380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94019425/04A RU2114827C1 (en) | 1991-08-28 | 1992-08-27 | Isatine or isatine oxime derivatives, method of synthesis of isatine oxime and a pharmaceutical composition |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0529636B1 (en) |
| JP (1) | JP3170584B2 (en) |
| KR (1) | KR100277481B1 (en) |
| AT (1) | ATE181552T1 (en) |
| AU (1) | AU655672B2 (en) |
| CA (1) | CA2076948C (en) |
| CZ (1) | CZ282759B6 (en) |
| DE (1) | DE69229461T2 (en) |
| DK (1) | DK0529636T3 (en) |
| FI (1) | FI107156B (en) |
| GE (1) | GEP20002329B (en) |
| HU (2) | HUT70753A (en) |
| MX (1) | MX9204914A (en) |
| NO (1) | NO301117B1 (en) |
| PL (1) | PL170920B1 (en) |
| RU (1) | RU2114827C1 (en) |
| SK (1) | SK280578B6 (en) |
| WO (1) | WO1993005043A1 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2109516T3 (en) | 1992-10-13 | 1998-01-16 | Warner Lambert Co | DERIVATIVES OF QUINOXALINODIONA AS EXCITATOR AMINO ACID ANTAGONISTS. |
| US5843945A (en) * | 1993-05-13 | 1998-12-01 | Neurosearch A/S | AMPA antagonists and a method of treatment |
| WO1994026747A1 (en) * | 1993-05-13 | 1994-11-24 | Neurosearch A/S | Ampa antagonists and a method of treatment therewith |
| DK81593D0 (en) * | 1993-07-07 | 1993-07-07 | Neurosearch As | NEW ISATIN OXIMIZE DERIVATIVES, THEIR PREPARATION AND USE |
| WO1996008495A1 (en) * | 1994-09-14 | 1996-03-21 | Neurosearch A/S | Fused indole and quinoxaline derivatives, their preparation and use |
| EE03355B1 (en) * | 1994-09-14 | 2001-02-15 | Neurosearch A/S | Indole-2,3-dione-3-oxime derivatives, their preparation and use |
| UA54403C2 (en) * | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | indole-2,3-dione-3-oxime derivatives, A PHARMACEUTICAL COMPOSITION, A METHOD FOR TREATING DISORDER OR DISEASE OF MAMMALS INCLUDING A MAN, AND A METHOD FOR PREPARATION OF Indole-2,3-dione-3-oxime derivatives |
| FR2768624B1 (en) | 1997-09-25 | 1999-11-12 | Oreal | USE OF AN EXCITING AMINO ACID INHIBITOR IN A COSMETIC OR DERMATOLOGICAL COMPOSITION FOR SENSITIVE SKIN AND COMPOSITION OBTAINED |
| CA2369746A1 (en) | 1999-05-19 | 2000-11-30 | Neurosearch A/S | Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders |
| CA2394292A1 (en) | 2000-01-24 | 2001-08-02 | Neurosearch A/S | Isatine derivatives with neurotrophic activity |
| AU2003273114A1 (en) | 2002-10-29 | 2004-05-25 | Sungkyunkwan University | Medicament component of berberine for the use of prevention and treatment of psycological dependence on and analgesic tolerance to morphine |
| AU2006317545B2 (en) | 2005-11-23 | 2012-04-12 | Aros Pharma Aps | Compositions and methods for modulating gated ion channels |
| ES2739395T3 (en) | 2012-12-19 | 2020-01-30 | Bayer Cropscience Ag | Indanylcarboxamides difluoromethyl-nicotinic as fungicides |
| CN106061938B (en) * | 2014-02-28 | 2019-04-12 | 住友化学株式会社 | The manufacturing method of 2- (halogenated methyl) -3- methyl nitrobenzene |
| BR112018068688B1 (en) | 2016-03-17 | 2023-02-14 | Fmc Corporation | PROCESS FOR CONVERTING S-ENANTIOMERS INTO ITS RACEMIC FORM, COMPOUND AND USE THEREOF |
| CN112266367B (en) * | 2017-11-15 | 2023-12-08 | 中山光禾医疗科技有限公司 | Preparation, raw materials, products and application of photocrosslinked hydrogel material |
| CN108912127B (en) * | 2018-08-27 | 2019-12-10 | 青岛农业大学 | Benzo [ b, e ] azepine compound based on isatin skeleton and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE69677B1 (en) * | 1989-12-11 | 1996-10-02 | Neurosearch As | Isatine derivatives their preparation and use |
-
1992
- 1992-08-26 MX MX9204914A patent/MX9204914A/en not_active IP Right Cessation
- 1992-08-26 CA CA002076948A patent/CA2076948C/en not_active Expired - Fee Related
- 1992-08-27 EP EP92114654A patent/EP0529636B1/en not_active Expired - Lifetime
- 1992-08-27 WO PCT/EP1992/001999 patent/WO1993005043A1/en active IP Right Grant
- 1992-08-27 JP JP50493393A patent/JP3170584B2/en not_active Expired - Fee Related
- 1992-08-27 HU HU9400595A patent/HUT70753A/en unknown
- 1992-08-27 KR KR1019940700676A patent/KR100277481B1/en not_active IP Right Cessation
- 1992-08-27 GE GEAP19922683A patent/GEP20002329B/en unknown
- 1992-08-27 CZ CZ94395A patent/CZ282759B6/en not_active IP Right Cessation
- 1992-08-27 AT AT92114654T patent/ATE181552T1/en not_active IP Right Cessation
- 1992-08-27 DK DK92114654T patent/DK0529636T3/en active
- 1992-08-27 SK SK238-94A patent/SK280578B6/en unknown
- 1992-08-27 RU RU94019425/04A patent/RU2114827C1/en not_active IP Right Cessation
- 1992-08-27 DE DE69229461T patent/DE69229461T2/en not_active Expired - Lifetime
- 1992-08-27 PL PL92302584A patent/PL170920B1/en unknown
- 1992-08-27 AU AU24820/92A patent/AU655672B2/en not_active Ceased
-
1994
- 1994-02-25 FI FI940889A patent/FI107156B/en active
- 1994-02-25 NO NO940676A patent/NO301117B1/en unknown
-
1995
- 1995-06-21 HU HU95P/P00323P patent/HU211632A9/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU94019425A (en) | DERIVATIVES OF IZATINOKSIMA, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT | |
| RU93005057A (en) | PHARMACEUTICAL COMPOUNDS, THYENOBENZODIAZEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION, PHARMOCOMPOSITION AND THEIR USE | |
| LV10860A (en) | Saturation of phenylalkylamine | |
| EP0285287A3 (en) | 3-benzazepine compounds for use in treating gastrointestinal motility disorders | |
| KR910002802A (en) | Derivatives of 1,2,3,4-tetrahydro-9-acridinamine | |
| HUT70753A (en) | Isatinoxime derivatives, process for preparing them and pharmaceutical compositions containing them | |
| ATE79257T1 (en) | USE OF TETRAHYDROBENZENE(C,D>INDOL-6CARBOXAMIDES IN THE MANUFACTURE OF PHARMACEUTICALS FOR THE TREATMENT OF ANXIETY CONDITIONS. | |
| DE69104314D1 (en) | Use of 1- [3- (dimethylamino) propyl] -1-phenylphthalenes for the treatment of cerebrovascular disorders. | |
| KR890011596A (en) | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for treating insomnia | |
| ES2061605T3 (en) | ARYLOXYPHENYLPROPYLAMINS AND THEIR PREPARATION AND USE. | |
| FI94354C (en) | Method for preparing pharmaceutically active peptides | |
| ES539123A0 (en) | A COMPOUND OF 3-INDOLCARBOXAMIDE | |
| ATE99934T1 (en) | HETEROARYL-3-OXO-PROPANNITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES. | |
| KR880001596A (en) | Dihydropyridine Compound-containing Brain Dysfunction | |
| DE68900516D1 (en) | THERAPEUTIC AGENTS FOR TREATING STOMACH. | |
| GR3002267T3 (en) | Dissymmetrical 1,4-dihydropyridine-3,5-dicarboxylic-acid derivatives, preparation processes and therapeutical use | |
| ATE143659T1 (en) | NEW ISATINEOXIME DERIVATIVES, THEIR PREPARATION AND USE | |
| SE8802428D0 (en) | NEW COMPOUNDS | |
| ATE198750T1 (en) | ISATINOXIM DERIVATIVES, THEIR PREPARATION AND USE | |
| DE3650311T2 (en) | Use of quinazolines for the manufacture of a medicament for the treatment and prevention of arrhythmia. | |
| KR880000383A (en) | 1,7-substituted heptin-2-one and its use in the treatment of neurological bladder disease | |
| DE3782229D1 (en) | USE OF 2-OXO-IMIDAZOLIDINE DERIVATIVES FOR THE TREATMENT OF KIDNEY DISEASES. | |
| DE69010606D1 (en) | 3-isoxazolone derivatives, their preparation and their use in therapy. | |
| RU92004313A (en) | DERIVATIVES OF QUINOLINA, THERAPEUTIC COMPOSITION, METHOD OF TREATMENT | |
| KR950017956A (en) | N-substituted azabicycloheptane derivatives, preparation methods and uses thereof |