RU94016341A - Method of preparing liposomal form of antitumor antibiotic
- Google Patents
Method of preparing liposomal form of antitumor antibiotic
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Publication number
RU94016341A
RU94016341ARU94016341/14ARU94016341ARU94016341ARU 94016341 ARU94016341 ARU 94016341ARU 94016341/14 ARU94016341/14 ARU 94016341/14ARU 94016341 ARU94016341 ARU 94016341ARU 94016341 ARU94016341 ARU 94016341A
Харьковское предприятие по производству иммунобиологических и лекарственных препаратов "Биолек" (UA)
Харьковское предприятие по производству иммунобиологических и лекарственных препаратов "Биолек"
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Application filed by Харьковское предприятие по производству иммунобиологических и лекарственных препаратов "Биолек" (UA), Харьковское предприятие по производству иммунобиологических и лекарственных препаратов "Биолек"filedCriticalХарьковское предприятие по производству иммунобиологических и лекарственных препаратов "Биолек" (UA)
Publication of RU94016341ApublicationCriticalpatent/RU94016341A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Medicinal Preparation
(AREA)
Abstract
FIELD: pharmacy, antibiotics. SUBSTANCE: phospholipids were dried under vacuum, emulsified in an aqueous medium containing glucose at amount 18-22 wt. -% and antibiotic at ratio antibiotic : phospholipids = 1:(17-20). Lipid emulsion is homogenized at 35-40 C under pressure 5.4x10-5.8x10Pa and prepared solution is subjected for sterilizing filtration and pouring. EFFECT: increased yield, enhanced quality of preparation. 5 tbl, 3 ex
Claims (1)
Изобретение относится к фармации, а именно к способу получения липосомального препарата, который может быть использован в качестве противоопухолевого средства. Изобретение направлено на повышение выхода целевого продукта и улучшение качества препарата. При производстве липосомального препарата фосфолипиды высушивают в вакууме, эмульгируют в водной среде, содержащей глюкозу в количестве 18 - 22 мас.% и антибиотик при соотношении антибиотик: фосфолипиды 1:17 - 20. Липидную эмульсию гомогенизируют при температуре 35 - 40oС и давлении 5,4•107 - 5,8•107Па. Полученный раствор подвергают стерилизующей фильтрации и разливу.The invention relates to pharmacy, and in particular to a method for producing a liposomal preparation, which can be used as an antitumor agent. The invention is aimed at increasing the yield of the target product and improving the quality of the drug. In the production of a liposomal preparation, phospholipids are dried in a vacuum, emulsified in an aqueous medium containing glucose in an amount of 18-22 wt.% And an antibiotic with an antibiotic: phospholipids ratio of 1:17 - 20. The lipid emulsion is homogenized at a temperature of 35-40 o C and a pressure of 5 4 • 10 7 - 5.8 • 10 7 Pa. The resulting solution is subjected to sterilizing filtration and spill.
RU94016341/14A1993-05-261994-04-28Method of preparing liposomal form of antitumor antibiotic
RU94016341A
(en)
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