RU94016198A - DERIVATIVES OF TETRAZOL-CONTAINING AMIDA, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS AND SALTS - Google Patents

DERIVATIVES OF TETRAZOL-CONTAINING AMIDA, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS AND SALTS

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Publication number
RU94016198A
RU94016198A RU94016198/04A RU94016198A RU94016198A RU 94016198 A RU94016198 A RU 94016198A RU 94016198/04 A RU94016198/04 A RU 94016198/04A RU 94016198 A RU94016198 A RU 94016198A RU 94016198 A RU94016198 A RU 94016198A
Authority
RU
Russia
Prior art keywords
isomers
amida
tetrazol
derivatives
salts
Prior art date
Application number
RU94016198/04A
Other languages
Russian (ru)
Other versions
RU2117664C1 (en
Inventor
Майкль О'Брайн Пэтрик
Эрманд Пикерд Джозеф
Форси Перчиз Клауд
Дейвид Рос Брус
Роберт Слискович Дреджо
Дейвид Уайт Эндриз
Original Assignee
Варнер-Ламберт Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Варнер-Ламберт Компани filed Critical Варнер-Ламберт Компани
Publication of RU94016198A publication Critical patent/RU94016198A/en
Application granted granted Critical
Publication of RU2117664C1 publication Critical patent/RU2117664C1/en

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Claims (1)

Соединения общей формулы (I)
Figure 00000001

где R1 означает фенил, замещенный фенил, нафтил, замещенный нафтил, гетероароматический остаток или углеводородный остаток с 1 - 18 атомами углерода, R2 и R3 - водород, галоид, гидроксил, алкил, алкенил, циклоалкил, незамещенный или замещенный фенил, гетероарил или вместе образуют спироалкильный остаток, R4 - углеводород с 1 - 20 атомами углерода, n - 0,1 или 2, которые представляют собой фармацевтически полезные соединения, которые могут применяться в качестве ингибиторов трансферазы ацилирования холестерина.Compounds of General Formula (I)
Figure 00000001

where R 1 means phenyl, substituted phenyl, naphthyl, substituted naphthyl, heteroaromatic residue or hydrocarbon residue with 1-18 carbon atoms, R 2 and R 3 - hydrogen, halo, hydroxyl, alkyl, alkenyl, cycloalkyl, unsubstituted or substituted phenyl, heteroaryl or together form a spiroalkyl residue, R 4 is a hydrocarbon with 1 to 20 carbon atoms, n is 0.1 or 2, which are pharmaceutically useful compounds that can be used as inhibitors of cholesterol acylation transferase.
RU94016198A 1991-08-22 1992-08-03 Derivatives of tetrazole-containing amide, a mixture of their isomers, separate isomers or pharmaceutically acceptable salts RU2117664C1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74856891A 1991-08-22 1991-08-22
US748,568 1991-08-22
US91364392A 1992-07-20 1992-07-20
US913,643 1992-07-20

Publications (2)

Publication Number Publication Date
RU94016198A true RU94016198A (en) 1995-12-27
RU2117664C1 RU2117664C1 (en) 1998-08-20

Family

ID=27114964

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94016198A RU2117664C1 (en) 1991-08-22 1992-08-03 Derivatives of tetrazole-containing amide, a mixture of their isomers, separate isomers or pharmaceutically acceptable salts

Country Status (20)

Country Link
EP (1) EP0600950B1 (en)
JP (1) JP3113678B2 (en)
KR (1) KR100221764B1 (en)
AT (1) ATE144501T1 (en)
AU (1) AU657790B2 (en)
CA (1) CA2114017C (en)
CZ (1) CZ281314B6 (en)
DE (1) DE69214827T2 (en)
DK (1) DK0600950T3 (en)
ES (1) ES2093270T3 (en)
FI (1) FI112221B (en)
GR (1) GR3021942T3 (en)
HK (1) HK1005187A1 (en)
HU (1) HU221190B1 (en)
MX (1) MX9204877A (en)
NO (1) NO300632B1 (en)
NZ (1) NZ244029A (en)
PT (1) PT100804B (en)
RU (1) RU2117664C1 (en)
WO (1) WO1993004052A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366987A (en) * 1991-08-22 1994-11-22 Warner-Lambert Company Isoxazolyl-substituted alkyl amide ACAT inhibitors
US5239082A (en) * 1992-08-03 1993-08-24 Warner-Lambert Company Sulfonamide tetrazole ACAT inhibitors
US5461049A (en) * 1994-05-27 1995-10-24 Warner-Lambert Company Amide tetrazole ACAT inhibitors
JP4035444B2 (en) * 2000-12-26 2008-01-23 株式会社ポーラファルマ Biphenyl derivatives
US7365199B2 (en) * 2001-04-20 2008-04-29 Fujifilm Corporation Dye-forming coupler, silver halide photographic light-sensitive material, and azomethine dye compound
US7320967B2 (en) * 2002-04-23 2008-01-22 L'oreal Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair
FR2845991B1 (en) * 2002-10-16 2005-02-04 Pf Medicament ALPHA-PHENYL ACETANILIDE DERIVATIVES AND THEIR USE IN HUMAN THERAPEUTICS
GB0316546D0 (en) 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds
UA85706C2 (en) 2004-05-06 2009-02-25 Уорнер-Ламберт Компани Ллси 4-phenylaminoquinazolin-6-yl amides
MY155662A (en) * 2009-06-22 2015-11-13 Sk Biopharmaceuticals Co Ltd Method for preparation of carbamic acid (r)-1-aryl-2-tetrazolyl-ethyl ester
CN102153591B (en) * 2011-01-17 2013-11-06 天津师范大学 Manganese (II) complex containing 2-(1H-tetrazole-5-methyl) pyridine and 5-nitroisophthalic acid mixed ligand and preparation method and application of manganese (II) complex
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5536447A (en) * 1978-09-07 1980-03-14 Otsuka Pharmaceut Co Ltd Butyramide derivative
US5073565A (en) * 1990-04-27 1991-12-17 Warner-Lambert Company Tetrazole ureas and thioureas and their use as acat inhibitors

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