RU94015830A - SUBSTITUTED PYRROLES - Google Patents
SUBSTITUTED PYRROLESInfo
- Publication number
- RU94015830A RU94015830A RU94015830/04A RU94015830A RU94015830A RU 94015830 A RU94015830 A RU 94015830A RU 94015830/04 A RU94015830/04 A RU 94015830/04A RU 94015830 A RU94015830 A RU 94015830A RU 94015830 A RU94015830 A RU 94015830A
- Authority
- RU
- Russia
- Prior art keywords
- lower alkyl
- amino
- formula
- compounds
- aryl
- Prior art date
Links
- 150000003233 pyrroles Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 150000007513 acids Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 206010000565 Acquired immunodeficiency syndrome Diseases 0.000 claims 1
- 208000006673 Asthma Diseases 0.000 claims 1
- 208000008787 Cardiovascular Disease Diseases 0.000 claims 1
- 208000002249 Diabetes Complications Diseases 0.000 claims 1
- 206010012655 Diabetic complications Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- -1 amino, carboxy Chemical group 0.000 claims 1
- 230000003698 anagen phase Effects 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 150000007514 bases Chemical class 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000003779 hair growth Effects 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000000771 oncological Effects 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
в которой R1 представляет собой низший алкил, низший циклоалкил, арил или низший аралкил, R2 - водород, арил или низший алкил, необязательно замещенные окси, ацилокси, амино, моно(низший алкил)амино, ди(низший алкил)амино, карбокси, низший алкоксикарбонилом или аминокарбонилом, а m и n равны 1 или 2, а также фармацевтически приемлемые соли кислотных соединений формулы I с основаниями и основных соединений формулы I с кислотами, которые можно использовать для лечения или предотвращения заболеваний, особенно для лечения или предотвращения воспалительных, иммунологических, онкологических, бронхолегочных, дерматологических или сердечно-сосудистых расстройств, для лечения астмы, СПИДа или диабетических осложнений, для стимуляции роста волос.In accordance with the present invention, compounds of formula I are provided.
in which R 1 represents lower alkyl, lower cycloalkyl, aryl or lower aralkyl, R 2 is hydrogen, aryl or lower alkyl, optionally substituted oxy, acyloxy, amino, mono (lower alkyl) amino, di (lower alkyl) amino, carboxy , lower alkoxycarbonyl or aminocarbonyl, and m and n are 1 or 2, as well as pharmaceutically acceptable salts of acidic compounds of formula I with bases and basic compounds of formula I with acids that can be used to treat or prevent diseases, especially to treat or prevent inflammation tionary, immunological, oncological, bronchopulmonary, dermatological and cardiovascular disorders, for the treatment of asthma, AIDS or diabetic complications, to stimulate hair growth.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB930902.2 | 1993-05-10 | ||
| GB9309602.2 | 1993-05-10 | ||
| GB939309602A GB9309602D0 (en) | 1993-05-10 | 1993-05-10 | Substituted pyrroles |
| GB9403249A GB9403249D0 (en) | 1993-05-10 | 1994-02-21 | Substituted pyrroles |
| GB9403249.7 | 1994-02-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94015830A true RU94015830A (en) | 1996-01-10 |
| RU2141960C1 RU2141960C1 (en) | 1999-11-27 |
Family
ID=26302877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94015830A RU2141960C1 (en) | 1993-05-10 | 1994-05-05 | Substituted pyrrols |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0624586B1 (en) |
| JP (1) | JP2668818B2 (en) |
| CN (1) | CN1048014C (en) |
| AT (1) | ATE184007T1 (en) |
| AU (1) | AU678435B2 (en) |
| BG (1) | BG98761A (en) |
| BR (1) | BR9401935A (en) |
| CA (1) | CA2121567A1 (en) |
| CZ (1) | CZ112894A3 (en) |
| DE (1) | DE69420310T2 (en) |
| DK (1) | DK0624586T3 (en) |
| ES (1) | ES2137281T3 (en) |
| FI (1) | FI106961B (en) |
| GR (1) | GR3031901T3 (en) |
| HR (1) | HRP940287B1 (en) |
| HU (1) | HU215954B (en) |
| IL (1) | IL109547A (en) |
| IS (1) | IS1690B (en) |
| LT (1) | LT3288B (en) |
| LV (1) | LV11173B (en) |
| NO (1) | NO301230B1 (en) |
| NZ (1) | NZ260475A (en) |
| RU (1) | RU2141960C1 (en) |
| SI (1) | SI0624586T1 (en) |
| SK (1) | SK53594A3 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723456A (en) * | 1993-12-07 | 1998-03-03 | Eli Lilly & Company | Therapeutic treatment for cardiovascular diseases |
| US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5843935A (en) * | 1993-12-07 | 1998-12-01 | Eli Lilly And Company | Protein kinase C inhibitors |
| HU219709B (en) * | 1993-12-07 | 2001-06-28 | Eli Lilly And Co. | Condensed indole derivatives of protein kinase c inhibitor activity, process for preparing them and pharmaceutical compositions containing them |
| PT817627E (en) * | 1993-12-23 | 2005-07-29 | Lilly Co Eli | PROTEIN INHIBITORS CINASE C |
| DE69505470T2 (en) * | 1994-08-04 | 1999-05-12 | F. Hoffmann-La Roche Ag, Basel | Pyrrolocarbazole |
| AU2217797A (en) * | 1996-03-20 | 1997-10-10 | Eli Lilly And Company | Synthesis of indolylmaleimides |
| KR100499190B1 (en) * | 1996-03-29 | 2006-04-17 | 교와 핫꼬 고교 가부시끼가이샤 | Hair restorer |
| US5859261A (en) * | 1997-03-20 | 1999-01-12 | Eli Lilly And Company | Synthesis of indolylmaleimides |
| PL366701A1 (en) | 2000-07-27 | 2005-02-07 | F.Hoffmann-La Roche Ag | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta |
| CN1582150B (en) * | 2001-10-30 | 2011-09-07 | 诺瓦提斯公司 | Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity |
| CA2393720C (en) | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
| CA2533861A1 (en) | 2003-08-08 | 2005-02-17 | Novartis Ag | Combinations comprising staurosporines |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3803620A1 (en) * | 1988-02-06 | 1989-08-17 | Goedecke Ag | INDOLOCARBAZOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME |
| IL89167A (en) * | 1988-02-10 | 1994-02-27 | Hoffmann La Roche | Substituted pyrroles, their manufacture and pharmaceutical compositions containing them |
| DE3833008A1 (en) * | 1988-09-29 | 1990-04-05 | Goedecke Ag | PYRROLOCARBOZOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT |
| MC2096A1 (en) * | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | SUBSTITUTED PYRROLES |
| CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
-
1994
- 1994-04-15 AU AU60555/94A patent/AU678435B2/en not_active Ceased
- 1994-04-26 CA CA002121567A patent/CA2121567A1/en not_active Abandoned
- 1994-05-02 DE DE69420310T patent/DE69420310T2/en not_active Expired - Fee Related
- 1994-05-02 ES ES94106812T patent/ES2137281T3/en not_active Expired - Lifetime
- 1994-05-02 EP EP94106812A patent/EP0624586B1/en not_active Expired - Lifetime
- 1994-05-02 AT AT94106812T patent/ATE184007T1/en not_active IP Right Cessation
- 1994-05-02 DK DK94106812T patent/DK0624586T3/en active
- 1994-05-02 SI SI9430273T patent/SI0624586T1/en unknown
- 1994-05-04 IL IL10954794A patent/IL109547A/en not_active IP Right Cessation
- 1994-05-04 HU HU9401298A patent/HU215954B/en not_active IP Right Cessation
- 1994-05-05 RU RU94015830A patent/RU2141960C1/en active
- 1994-05-05 HR HR9309602.2A patent/HRP940287B1/en not_active IP Right Cessation
- 1994-05-06 NO NO941682A patent/NO301230B1/en not_active IP Right Cessation
- 1994-05-06 NZ NZ260475A patent/NZ260475A/en unknown
- 1994-05-06 CZ CZ941128A patent/CZ112894A3/en unknown
- 1994-05-09 LV LVP-94-100A patent/LV11173B/en unknown
- 1994-05-09 LT LTIP1927A patent/LT3288B/en not_active IP Right Cessation
- 1994-05-09 JP JP6119542A patent/JP2668818B2/en not_active Expired - Fee Related
- 1994-05-09 SK SK535-94A patent/SK53594A3/en unknown
- 1994-05-09 CN CN94105846A patent/CN1048014C/en not_active Expired - Fee Related
- 1994-05-09 IS IS4162A patent/IS1690B/en unknown
- 1994-05-09 BR BR9401935A patent/BR9401935A/en not_active Application Discontinuation
- 1994-05-10 FI FI942158A patent/FI106961B/en not_active IP Right Cessation
- 1994-05-10 BG BG98761A patent/BG98761A/en unknown
-
1999
- 1999-11-18 GR GR990402995T patent/GR3031901T3/en unknown
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