RU94004151A - METHOD FOR PRODUCING HYDROCHLORIDE 1-ISOPROPYLAMINO-3- (1-NAFTOXY) -2-PROPANOL - Google Patents

METHOD FOR PRODUCING HYDROCHLORIDE 1-ISOPROPYLAMINO-3- (1-NAFTOXY) -2-PROPANOL

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Publication number
RU94004151A
RU94004151A RU94004151/04A RU94004151A RU94004151A RU 94004151 A RU94004151 A RU 94004151A RU 94004151/04 A RU94004151/04 A RU 94004151/04A RU 94004151 A RU94004151 A RU 94004151A RU 94004151 A RU94004151 A RU 94004151A
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RU
Russia
Prior art keywords
isopropylamino
amount
producing
propanol
naphthoxy
Prior art date
Application number
RU94004151/04A
Other languages
Russian (ru)
Other versions
RU2063959C1 (en
Inventor
Н.Г. Желтоног
Ю.В. Жеребцов
А.Г. Базанов
А.Л. Розен
О.К. Соколова
Original Assignee
Научно-производственное объединение "Государственный институт прикладной химии"
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Publication date
Application filed by Научно-производственное объединение "Государственный институт прикладной химии" filed Critical Научно-производственное объединение "Государственный институт прикладной химии"
Priority to RU94004151A priority Critical patent/RU2063959C1/en
Priority claimed from RU94004151A external-priority patent/RU2063959C1/en
Publication of RU94004151A publication Critical patent/RU94004151A/en
Application granted granted Critical
Publication of RU2063959C1 publication Critical patent/RU2063959C1/en

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Claims (1)

Изобретение относится к способам получения гидрохлорида 1-изопропиламино -3-(1-нафтокси) -2-пропанола - лекарственного средства, известного под названием анаприлин и применяемого в медицине в качестве β - адреноблокатора неизбирательного действия. Изобретение решает задачу увеличения выхода гидрохлорида 1-изопропиламино-3-(1-нафтокси)-2-пропанола за счет повышения выхода промежуточных продуктов и снижения интенсивности протекания побочных реакций, особенно на стадии получения эпоксида, а также обеспечивает сокращение видов и количества отходов. Сущность изобретения заключается в том, что первоначально проводят взаимодействие смеси эпихлоргидрина и 1-нафтола с гидроксидом натрия, взятым в количестве 1 - 3 мас.% от его общего количества при 25 - 30°С в течение 15 - 30 мин, затем в реакционную смесь добавляют воду в количестве 90 - 110 мас.% в расчете на реакционную смесь и продолжают взаимодействие с оставшимся количеством гидроксида натрия при 60 - 65°С в течение 30 - 60 мин, после чего отделяют органическую фазу, обрабатывают ее изопропиламином, отгоняют непрореагировавший изопропиламин, остаток растворяют в изопропиловом спирте и обрабатывают концентрированной соляной кислотой при РН 3,5 - 5,0.The invention relates to methods for producing 1-isopropylamino-3- (1-naphthoxy) -2-propanol hydrochloride, a drug known as anaprilin and used in medicine as a β-blocker of non-selective action. The invention solves the problem of increasing the yield of 1-isopropylamino-3- (1-naphthoxy) -2-propanol hydrochloride by increasing the yield of intermediate products and reducing the intensity of side reactions, especially at the stage of producing epoxide, and also reduces the types and quantities of waste. The essence of the invention lies in the fact that they initially carry out the interaction of a mixture of epichlorohydrin and 1-naphthol with sodium hydroxide, taken in an amount of 1 - 3 wt.% Of its total amount at 25 - 30 ° C for 15 - 30 minutes, then into the reaction mixture water is added in an amount of 90 to 110 wt.%, based on the reaction mixture, and the reaction is continued with the remaining amount of sodium hydroxide at 60 to 65 ° C for 30 to 60 minutes, after which the organic phase is separated, treated with isopropylamine, the unreacted isopropylamine is distilled off residue p It is dissolved in isopropyl alcohol and treated with concentrated hydrochloric acid at PH 3.5 - 5.0.
RU94004151A 1994-02-08 1994-02-08 Method of synthesis of 1-isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride RU2063959C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU94004151A RU2063959C1 (en) 1994-02-08 1994-02-08 Method of synthesis of 1-isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU94004151A RU2063959C1 (en) 1994-02-08 1994-02-08 Method of synthesis of 1-isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride

Publications (2)

Publication Number Publication Date
RU94004151A true RU94004151A (en) 1995-09-27
RU2063959C1 RU2063959C1 (en) 1996-07-20

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Family Applications (1)

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RU94004151A RU2063959C1 (en) 1994-02-08 1994-02-08 Method of synthesis of 1-isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride

Country Status (1)

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RU (1) RU2063959C1 (en)

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