RU94000717A - TRICYCLIC CONDENSED HETEROCYCLIC COMPOUNDS, METHOD OF THEIR PREPARATION, APPLICATION OF COMPOSITION FORMS, METHOD OF TREATMENT - Google Patents
TRICYCLIC CONDENSED HETEROCYCLIC COMPOUNDS, METHOD OF THEIR PREPARATION, APPLICATION OF COMPOSITION FORMS, METHOD OF TREATMENTInfo
- Publication number
- RU94000717A RU94000717A RU94000717/04A RU94000717A RU94000717A RU 94000717 A RU94000717 A RU 94000717A RU 94000717/04 A RU94000717/04 A RU 94000717/04A RU 94000717 A RU94000717 A RU 94000717A RU 94000717 A RU94000717 A RU 94000717A
- Authority
- RU
- Russia
- Prior art keywords
- treatment
- preparation
- application
- heterocyclic compounds
- condensed heterocyclic
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- -1 2-piperazinyl Chemical group 0.000 claims 2
- 206010001897 Alzheimer's disease Diseases 0.000 claims 1
- 102000003914 Cholinesterases Human genes 0.000 claims 1
- 108090000322 Cholinesterases Proteins 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 229940048961 cholinesterase Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000001747 exhibiting Effects 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
в которой Аr представляет собой необязательно замещенную трехядерную конденсированную группу с бензольным кольцом, содержащую по крайней мере одно гетероциклическое кольцо в качестве компонента структуры; n является целым числом от 2 до 10; R1 представляет собой H или необязательно замещенную углеводородную группу, которые могут отличаться друг от друга при n - повторении; и У представляет собой необязательно замещенную 4-пиперидинильную, 2-пиперазинильную или 4-бензил-1-пиперидинильную группу или их соли, проявляющие отличную ингибирующую активность против холинэстеразы и репоглощения моноамина, и таким образом являющиеся пригодными в качестве медикаментозных средств для лечения и/или профилактики сенильной деменции.New compounds of the formula
in which Ar represents an optionally substituted tricyclic fused group with a benzene ring containing at least one heterocyclic ring as a component of the structure; n is an integer from 2 to 10; R 1 represents H or an optionally substituted hydrocarbon group, which may differ from each other when n is repeated; and Y is an optionally substituted 4-piperidinyl, 2-piperazinyl or 4-benzyl-1-piperidinyl group or their salts exhibiting excellent inhibitory activity against cholinesterase and monoamine reabsorption, and thus being suitable as medicament for treatment and / or prevention of senile dementia.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP05-005535 | 1993-01-18 | ||
| JP05-173287 | 1993-07-13 | ||
| JP05-239672 | 1993-09-27 | ||
| JP05-299827 | 1993-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU94000717A true RU94000717A (en) | 1995-08-27 |
Family
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