RU93058393A - ETHANOLAMINE DERIVATIVES THAT DISTRIBUTE SYMPATHOMOMETIC AND ANTIPOLAKIURIAL ACTIVITY, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT - Google Patents
ETHANOLAMINE DERIVATIVES THAT DISTRIBUTE SYMPATHOMOMETIC AND ANTIPOLAKIURIAL ACTIVITY, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENTInfo
- Publication number
- RU93058393A RU93058393A RU93058393/04A RU93058393A RU93058393A RU 93058393 A RU93058393 A RU 93058393A RU 93058393/04 A RU93058393/04 A RU 93058393/04A RU 93058393 A RU93058393 A RU 93058393A RU 93058393 A RU93058393 A RU 93058393A
- Authority
- RU
- Russia
- Prior art keywords
- group
- additionally substituted
- acyl
- activity
- pharmaceutical composition
- Prior art date
Links
- 230000000694 effects Effects 0.000 title claims 2
- 150000002169 ethanolamines Chemical class 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 206010036018 Pollakiuria Diseases 0.000 claims 1
- 210000002700 Urine Anatomy 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 230000001975 sympathomimetic Effects 0.000 claims 1
- 230000036318 urination frequency Effects 0.000 claims 1
Claims (1)
где R1 - арильная или гетероциклическая группа, каждая из которых может содержать такие заместители, как атом галогена и т.д.; R2 - атом водорода, атом галогена, нитро-группа, оксигруппа, низшая алкильная группа, дополнительно замещенная ацильной группой, низшая алкенильная группа, дополнительно замещенная ацильной группой, низшая алкоксигруппа, дополнительно замещенная ацильной группой, или амино-группа, дополнительно замещенная ацил (низшей) алкильной группой; R3 - атом водорода, N - защитная группа или низшая алкильная группа, дополнительно замещенная низшей алкилтио-группой, n - целое число от 0 до 3, а жирная линия означает простую связь или двойную связь, при этом, если в равняется 1, то R1 - конденсированная ароматическая углеводородная группа или гетероциклическая группа, каждая из которых может содержать такие заместители, как галоген и т.д. и т.п.; и их фармацевтически приемлимые соли, способы получения указанных соединений и фармацевтическая композиция, включающая указанные соединения.The invention considers new ethanolamine derivatives with selective sympathomimetic activity and activity against urinary frequency of urine, which can be provided as a general formula
where R 1 is an aryl or heterocyclic group, each of which may contain substituents such as a halogen atom, etc .; R 2 is a hydrogen atom, a halogen atom, a nitro group, a hydroxy group, a lower alkyl group additionally substituted by an acyl group, a lower alkenyl group additionally substituted by an acyl group, a lower alkoxy group additionally substituted by an acyl group, or an amino group additionally substituted by acyl ( lower) alkyl group; R 3 is a hydrogen atom, N is a protecting group or a lower alkyl group additionally substituted by a lower alkylthio group, n is an integer from 0 to 3, and the bold line denotes a simple bond or a double bond, while if equals 1, then R 1 is a condensed aromatic hydrocarbon group or a heterocyclic group, each of which may contain substituents such as halogen, etc. etc.; and their pharmaceutically acceptable salts, methods for producing these compounds, and a pharmaceutical composition comprising these compounds.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929202236A GB9202236D0 (en) | 1992-02-03 | 1992-02-03 | New ethanolamine derivatives,a process for the preparation thereof and pharmaceutical composition comprising the same |
GB9202236.7 | 1992-02-03 | ||
GB9217991.0 | 1992-08-24 | ||
PCT/JP1993/000113 WO1993015041A1 (en) | 1992-02-03 | 1993-02-01 | Ethanolamine derivatives having sympathomimetic and anti-pollakiuria activities |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93058393A true RU93058393A (en) | 1996-04-27 |
RU2125983C1 RU2125983C1 (en) | 1999-02-10 |
Family
ID=10709721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93058393A RU2125983C1 (en) | 1992-02-03 | 1993-02-01 | Ethanolamine derivatives, method of their synthesis, pharmaceutical composition, method of treatment |
Country Status (3)
Country | Link |
---|---|
GB (1) | GB9202236D0 (en) |
RU (1) | RU2125983C1 (en) |
ZA (1) | ZA93591B (en) |
-
1992
- 1992-02-03 GB GB929202236A patent/GB9202236D0/en active Pending
-
1993
- 1993-01-27 ZA ZA93591A patent/ZA93591B/en unknown
- 1993-02-01 RU RU93058393A patent/RU2125983C1/en not_active IP Right Cessation
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