RU93058194A - AGENTS OF IMPROVEMENT OF THE IMAGE, COMBINATION OF MELANINE, PARAMAGNETIC MELANIN, AGENT OF CHANGE OF RELAXATION FACTOR, COMMUNICATION INCLUSION, WAYS OF RECEIVING AN AGENT, IMPROVING THE IMAGE OF THE MONUMENT - Google Patents

AGENTS OF IMPROVEMENT OF THE IMAGE, COMBINATION OF MELANINE, PARAMAGNETIC MELANIN, AGENT OF CHANGE OF RELAXATION FACTOR, COMMUNICATION INCLUSION, WAYS OF RECEIVING AN AGENT, IMPROVING THE IMAGE OF THE MONUMENT

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RU93058194A
RU93058194A RU93058194/14A RU93058194A RU93058194A RU 93058194 A RU93058194 A RU 93058194A RU 93058194/14 A RU93058194/14 A RU 93058194/14A RU 93058194 A RU93058194 A RU 93058194A RU 93058194 A RU93058194 A RU 93058194A
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RU
Russia
Prior art keywords
melanin
metal
image
agent
paramagnetic
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RU93058194/14A
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Russian (ru)
Inventor
Ф.Уильямс Роберт
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Борд Оф Риджентс, Дзе Юниверсити Оф Техас Системз
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Publication of RU93058194A publication Critical patent/RU93058194A/en

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Настоящее изобретение относится к агенту усиления изображения, включающему парамагнитный меланин, комбинированный по существу с недиссоциируемым металлом, индуцирующим сигнал. Металл, индуцирующий сигнал, имеет константу ассоциации для своей комбинации с меланином по меньшей мере около 1020. После суспендирования или растворения в воде металл остается недиссоциированным. Предпочтительным металлом, индуцирующим сигнал, является парамагнитный или супермагнитный металл для магнитно-резонансной визуализации. Предпочтительными металлами являются гадолиний, железо, никель, медь, эрбий, европий, празеодимий, диспрозий, гольмий, хром или марганец. Гадолиний является наиболее эффективным металлом. Металл включается в меланин в ионной форме или в форме частиц. Могут использоваться меланины, которые особенно полезны для модифицирования ультразвуковых изображений путем усиления изображения, полученного от излучения и детекции высокочастотных звуковых волн. Металлы, излучающие гамма-частицы, также могут использоваться для усиления изображений, получающихся в результате сканирования излучения гамма-частиц. Для сканирования гамма-частиц предпочитаются 51хром, 68галлий, 99mтехнетий и IIIиндий. Кроме того, природный или синтезированный меланин сам по себе является эффективным агентом усиления изображения при МРВ вследствие способности регулировать содержание свободных радикалов в полимерах меланина.The present invention relates to an image intensifying agent comprising paramagnetic melanin combined substantially with a non-dissociable metal inducing a signal. The signal-inducing metal has an association constant for its combination with melanin of at least about 10 20 . After suspension or dissolution in water, the metal remains undissociated. A preferred signal inducing metal is a paramagnetic or supermagnetic metal for magnetic resonance imaging. Preferred metals are gadolinium, iron, nickel, copper, erbium, europium, praseodymium, dysprosium, holmium, chromium or manganese. Gadolinium is the most effective metal. The metal is incorporated into melanin in ionic or particulate form. Melanins can be used, which are especially useful for modifying ultrasound images by amplifying an image obtained from radiation and detecting high-frequency sound waves. Metals emitting gamma particles can also be used to enhance images resulting from scanning radiation of gamma particles. For scanning gamma particles, 51 chromium, 68 gallium, 99m technetium and III indium are preferred. In addition, natural or synthesized melanin itself is an effective agent for image enhancement during MRI due to the ability to regulate the content of free radicals in melanin polymers.
RU93058194/14A 1991-04-15 1992-04-15 AGENTS OF IMPROVEMENT OF THE IMAGE, COMBINATION OF MELANINE, PARAMAGNETIC MELANIN, AGENT OF CHANGE OF RELAXATION FACTOR, COMMUNICATION INCLUSION, WAYS OF RECEIVING AN AGENT, IMPROVING THE IMAGE OF THE MONUMENT RU93058194A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US685,937 1991-04-15

Publications (1)

Publication Number Publication Date
RU93058194A true RU93058194A (en) 1996-11-10

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