RU93046319A - NEW DERIVATIVES OF 3,4-DIHYDROISOCHINOLINE, METHOD FOR PRODUCING THEM, AND NEW PHARMACEUTICAL APPLICATION OF CARBOCYCLICALLY AND HETEROCYCLICALLY ANNELATED DIGYDROPYRIDINES - Google Patents
NEW DERIVATIVES OF 3,4-DIHYDROISOCHINOLINE, METHOD FOR PRODUCING THEM, AND NEW PHARMACEUTICAL APPLICATION OF CARBOCYCLICALLY AND HETEROCYCLICALLY ANNELATED DIGYDROPYRIDINESInfo
- Publication number
- RU93046319A RU93046319A RU93046319/14A RU93046319A RU93046319A RU 93046319 A RU93046319 A RU 93046319A RU 93046319/14 A RU93046319/14 A RU 93046319/14A RU 93046319 A RU93046319 A RU 93046319A RU 93046319 A RU93046319 A RU 93046319A
- Authority
- RU
- Russia
- Prior art keywords
- annelated
- new
- dihydroisochinoline
- digydropyridines
- carbocyclically
- Prior art date
Links
- NKSZCPBUWGZONP-UHFFFAOYSA-N 3,4-dihydroisoquinoline Chemical class C1=CC=C2C=NCCC2=C1 NKSZCPBUWGZONP-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 210000004556 Brain Anatomy 0.000 claims 1
- 230000023555 blood coagulation Effects 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 230000001684 chronic Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
Claims (1)
а также их таутомерных форм формулы II
где A является одной из аннелированных кольцевых систем
и X является группой OR1, NHR2 или NR3R4 в качестве средства для защиты головного мозга, средства для лечения хронических воспалительных процессов и в качестве средства для торможения свертываемости крови. Изобретение касается также новых соединений общей формулы Iе, которые определены в тексте описания изобретения и приведенной выше общей формулой I.The invention relates to the use of carbocyclic or heterocyclic annelated dihydropyridines of the formula I
as well as their tautomeric forms of formula II
where A is one of the annelated ring systems
and X is a group of OR 1 , NHR 2 or NR 3 R 4 as an agent for protecting the brain, an agent for treating chronic inflammatory processes, and as an agent for inhibiting blood coagulation. The invention also relates to new compounds of the general formula Ie, which are defined in the text of the description of the invention and the above general formula I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4041482A DE4041482A1 (en) | 1990-12-22 | 1990-12-22 | NEW PHARMACEUTICAL USE OF CARBOCYCLIC AND HETEROCYCLICALLY ANNELATED DIHYDROPYRIDINE |
| DEP4041482.5 | 1990-12-22 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94046320/14A Division RU2149000C1 (en) | 1990-12-22 | 1991-12-20 | Use of carbocyclic and heterocyclic anellated dihydropyridines and their pharmaceutically acceptable salts as blocker of nonselective channel of cations in protection of brain and for treatment of patients with chronic bronchial asthma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93046319A true RU93046319A (en) | 1997-01-27 |
| RU2115647C1 RU2115647C1 (en) | 1998-07-20 |
Family
ID=6421218
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93046319A RU2115647C1 (en) | 1990-12-22 | 1991-12-20 | 3,4-dihydroisoquinoline derivatives or pharmaceutically acceptable salts thereof, method of preparation thereof, and pharmaceutical composition based thereon |
| RU94046320/14A RU2149000C1 (en) | 1990-12-22 | 1991-12-20 | Use of carbocyclic and heterocyclic anellated dihydropyridines and their pharmaceutically acceptable salts as blocker of nonselective channel of cations in protection of brain and for treatment of patients with chronic bronchial asthma |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94046320/14A RU2149000C1 (en) | 1990-12-22 | 1991-12-20 | Use of carbocyclic and heterocyclic anellated dihydropyridines and their pharmaceutically acceptable salts as blocker of nonselective channel of cations in protection of brain and for treatment of patients with chronic bronchial asthma |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US5665729A (en) |
| EP (2) | EP0781556A1 (en) |
| JP (1) | JP3283877B2 (en) |
| KR (1) | KR100227953B1 (en) |
| AT (1) | ATE177948T1 (en) |
| AU (1) | AU666107B2 (en) |
| BR (1) | BR1100520A (en) |
| CA (1) | CA2098917A1 (en) |
| CZ (3) | CZ282454B6 (en) |
| DE (3) | DE9017900U1 (en) |
| DK (1) | DK0563128T3 (en) |
| ES (1) | ES2129040T3 (en) |
| FI (1) | FI105026B (en) |
| GR (1) | GR3030341T3 (en) |
| HK (1) | HK1010683A1 (en) |
| HR (1) | HRP940721B1 (en) |
| HU (1) | HU217819B (en) |
| ID (1) | ID16001A (en) |
| IE (3) | IE990430A1 (en) |
| IL (1) | IL100450A (en) |
| MX (1) | MX9102765A (en) |
| NO (1) | NO179515C (en) |
| NZ (1) | NZ241140A (en) |
| PL (1) | PL172262B1 (en) |
| PT (1) | PT99901B (en) |
| RU (2) | RU2115647C1 (en) |
| SG (1) | SG43064A1 (en) |
| SI (1) | SI9111975B (en) |
| SK (1) | SK281017B6 (en) |
| TW (1) | TW283145B (en) |
| WO (1) | WO1992011010A1 (en) |
| YU (1) | YU48063B (en) |
| ZA (1) | ZA9110116B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0957092A1 (en) * | 1992-06-22 | 1999-11-17 | Boehringer Ingelheim Pharma KG | Ring-closed dihydropyridines and their use in the preparation of pharmaceutical compositions |
| PT736012E (en) * | 1993-12-21 | 2001-03-30 | Boehringer Ingelheim Pharma | CYCLED DI-HYDROPYRIDINES AND THEIR USE FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS |
| DE4343683A1 (en) * | 1993-12-21 | 1995-06-22 | Boehringer Ingelheim Kg | Anellated dihydropyridines and their use for the preparation of pharmaceutical preparations |
| GB2341318A (en) * | 1998-09-14 | 2000-03-15 | Boehringer Ingelheim Pharma | A Dihydroisoquinoline (LOE 908) and Traumatic Brain Injury. |
| EP1482882B1 (en) * | 2002-02-11 | 2011-09-14 | Gold-T Tech, Inc. | Implantable device for preventing thrombus formation |
| DE102004055633A1 (en) * | 2004-11-12 | 2006-05-18 | Schering Ag | New 5-substituted quinoline and isoquinoline derivatives are glucocorticoid receptor binders useful for treating inflammatory diseases e.g. alveolitis, Sjogren's syndrome, atopic dermatitis, acute lymphatic leukemia, rhinitis and emesis |
| JP5148636B2 (en) * | 2007-03-15 | 2013-02-20 | エフ．ホフマン−ラ ロシュ アーゲー | Malonamide as an orexin antagonist |
| CZ20106A3 (en) * | 2010-01-05 | 2011-08-10 | Zentiva, K. S | Process for preparing 6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3-4-dihydroisoquinoline |
| EP2420237A1 (en) | 2010-08-11 | 2012-02-22 | Ville Takio | Fluorinated derivatives of endogenous isoquinolines for use in the treatment of diseases mediated through endogenous isoquinoline pathways |
| KR101645930B1 (en) | 2014-12-16 | 2016-08-05 | (주) 우수 | The towel dispenser |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3013906A1 (en) * | 1980-04-11 | 1981-10-15 | C.H. Boehringer Sohn, 6507 Ingelheim | SUBSTITUTED (ALPHA) -AMINOCARBONYL-L-BENZYL-3,4-DIHYDRO-ISOCHINOLINE, METHOD FOR THE PRODUCTION AND USE THEREOF |
| DE3621413A1 (en) * | 1986-06-26 | 1988-01-07 | Boehringer Ingelheim Kg | USE OF CARBOCYCLIC AND HETEROCYCLICALLY FURNISHED DIHYDROPYRIDINE AS A CARDIOPROTECTIVE AGENT AND NEW HETEROCYCLIC AND CARBOCYCLICALLY FURNISHED DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND ITS ADDITIONAL PRODUCTS |
| IL86131A0 (en) * | 1987-04-24 | 1988-11-15 | Boehringer Ingelheim Kg | Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them |
| DE3827727A1 (en) * | 1988-08-16 | 1990-02-22 | Boehringer Ingelheim Kg | ANALYZED TETRAHYDROPYRIDINE IGNESE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE OF SUCH CONNECTIONS FOR CARDIRO PROTECTION |
-
1990
- 1990-12-22 DE DE9017900U patent/DE9017900U1/en not_active Expired - Lifetime
- 1990-12-22 DE DE4041482A patent/DE4041482A1/en not_active Ceased
-
1991
- 1991-12-20 WO PCT/EP1991/002470 patent/WO1992011010A1/en active IP Right Grant
- 1991-12-20 IE IE19990430A patent/IE990430A1/en unknown
- 1991-12-20 EP EP96119881A patent/EP0781556A1/en not_active Withdrawn
- 1991-12-20 PT PT99901A patent/PT99901B/en not_active IP Right Cessation
- 1991-12-20 IL IL10045091A patent/IL100450A/en not_active IP Right Cessation
- 1991-12-20 AU AU90802/91A patent/AU666107B2/en not_active Ceased
- 1991-12-20 ES ES92901178T patent/ES2129040T3/en not_active Expired - Lifetime
- 1991-12-20 DK DK92901178T patent/DK0563128T3/en active
- 1991-12-20 AT AT92901178T patent/ATE177948T1/en not_active IP Right Cessation
- 1991-12-20 DE DE59109115T patent/DE59109115D1/en not_active Expired - Fee Related
- 1991-12-20 CA CA002098917A patent/CA2098917A1/en not_active Abandoned
- 1991-12-20 SG SG1996003170A patent/SG43064A1/en unknown
- 1991-12-20 JP JP50207392A patent/JP3283877B2/en not_active Expired - Fee Related
- 1991-12-20 SK SK617-93A patent/SK281017B6/en unknown
- 1991-12-20 CZ CZ952846A patent/CZ282454B6/en not_active IP Right Cessation
- 1991-12-20 RU RU93046319A patent/RU2115647C1/en not_active IP Right Cessation
- 1991-12-20 PL PL91299674A patent/PL172262B1/en unknown
- 1991-12-20 EP EP92901178A patent/EP0563128B1/en not_active Expired - Lifetime
- 1991-12-20 KR KR1019930701908A patent/KR100227953B1/en not_active IP Right Cessation
- 1991-12-20 IE IE448691A patent/IE914486A1/en not_active Application Discontinuation
- 1991-12-20 HU HU9301820A patent/HU217819B/en not_active IP Right Cessation
- 1991-12-20 IE IE20001043A patent/IE20001043A1/en unknown
- 1991-12-20 CZ CZ19931213A patent/CZ289533B6/en not_active IP Right Cessation
- 1991-12-20 RU RU94046320/14A patent/RU2149000C1/en not_active IP Right Cessation
- 1991-12-23 YU YU197591A patent/YU48063B/en unknown
- 1991-12-23 ZA ZA9110116A patent/ZA9110116B/en unknown
- 1991-12-23 NZ NZ241140A patent/NZ241140A/en unknown
- 1991-12-23 TW TW080110028A patent/TW283145B/zh active
- 1991-12-23 MX MX9102765A patent/MX9102765A/en not_active IP Right Cessation
- 1991-12-23 SI SI9111975A patent/SI9111975B/en unknown
-
1993
- 1993-06-14 FI FI932709A patent/FI105026B/en active
- 1993-06-21 NO NO932279A patent/NO179515C/en unknown
-
1994
- 1994-10-21 HR HRP-1975/91A patent/HRP940721B1/en not_active IP Right Cessation
-
1995
- 1995-06-01 US US08/456,357 patent/US5665729A/en not_active Expired - Fee Related
- 1995-06-01 US US08/458,069 patent/US6034094A/en not_active Expired - Fee Related
- 1995-06-01 US US08/456,889 patent/US5686462A/en not_active Expired - Fee Related
-
1996
- 1996-05-27 CZ CZ19961523A patent/CZ289685B6/en not_active IP Right Cessation
-
1997
- 1997-05-13 BR BR1100520-3A patent/BR1100520A/en active IP Right Grant
- 1997-06-13 ID IDP972024A patent/ID16001A/en unknown
-
1998
- 1998-10-21 HK HK98111437A patent/HK1010683A1/en not_active IP Right Cessation
-
1999
- 1999-05-27 GR GR990401430T patent/GR3030341T3/en unknown
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