RU93046283A -
NEW BENZODIAZEPINA DERIVATIVES, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION
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NEW BENZODIAZEPINA DERIVATIVES, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION
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Publication number
RU93046283A
RU93046283ARU93046283/04ARU93046283ARU93046283ARU 93046283 ARU93046283 ARU 93046283ARU 93046283/04 ARU93046283/04 ARU 93046283/04ARU 93046283 ARU93046283 ARU 93046283ARU 93046283 ARU93046283 ARU 93046283A
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Application filed by Яманоути Фармасьютикал Ко., Лтд.filedCriticalЯманоути Фармасьютикал Ко., Лтд.
Publication of RU93046283ApublicationCriticalpatent/RU93046283A/en
Настоящее изобретение касается новых бензодиазепиновых производных, представленных нижеследующей общей формулой:
в которой R1 представляет собой группу арила, или ароматический гетероциклический радикал 5-членной моноциклической, 6-членной моноциклической или 5- и 6-членной бициклической структуры, который может быть необязательно замещенным; R2 представляет собой группу арила, которая может быть необязательно замещенной, лекарственных композиций, включающих эти соединения, и способа их получения. Соединения формулы проявляют антагонизм к рецептору ССК - В и обладают действием, подавляющим секрецию желудочной кислоты, вызванную стимулятором пентагастрина, и ввиду этого находят полезное применение в качестве лекарства от заболеваний, связанных с рецептором ССК - В и гастриновым рецептором.The present invention relates to new benzodiazepine derivatives represented by the following general formula:
in which R 1 represents an aryl group, or an aromatic heterocyclic radical of a 5-membered monocyclic, 6-membered monocyclic or 5 and 6-membered bicyclic structure, which may be optionally substituted; R 2 is an aryl group, which may be optionally substituted, drug compositions comprising these compounds, and a method for their preparation. The compounds of the formula show an antagonism of the CCK-B receptor and have an effect that suppresses gastric acid secretion caused by the pentagastrin stimulant, and therefore find useful use as a cure for diseases associated with the CCK-B receptor and gastrin receptor.
RU93046283/04A1990-12-251991-12-17
NEW BENZODIAZEPINA DERIVATIVES, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION
RU93046283A
(en)
PIRIDINE IMIDAZO DERIVATIVES THAT INHIBIT THE GASTRIC ACID SECRETION, PROCEDURE FOR THE PREPARATION OF SUCH DERIVATIVES, PHARMACEUTICAL COMPOSITION, USE OF SUCH DERIVATIVES FOR THE PREPARATION OF MEDICINES, AND INTERMEDIARY COMPOUNDS.
Substituted thieno-imidazole derivatives, process for their preparation, pharmaceutical compositions containing them and their use as gastric secretion inhibitors, gastric protecting agents and as medicaments against intestinal inflammation
6-FLUORO-3,5-DIHYDROXYCARBONIC ACIDS AND THEIR DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, THEIR USE AS MEDICINAL PRODUCTS, PHARMACEUTICAL PREPARATIONS AND INTERMEDIATE PRODUCTS.
