RU93042877A - METHOD FOR IDENTIFICATION OF ANTIBODY, ORGANIC MOLECULE, PHARMACEUTICAL COMPOSITION, NUCLEIC ACID, VECTOR, CELL, METHOD FOR PRODUCING A CARRIER - Google Patents

METHOD FOR IDENTIFICATION OF ANTIBODY, ORGANIC MOLECULE, PHARMACEUTICAL COMPOSITION, NUCLEIC ACID, VECTOR, CELL, METHOD FOR PRODUCING A CARRIER

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Publication number
RU93042877A
RU93042877A RU93042877/13A RU93042877A RU93042877A RU 93042877 A RU93042877 A RU 93042877A RU 93042877/13 A RU93042877/13 A RU 93042877/13A RU 93042877 A RU93042877 A RU 93042877A RU 93042877 A RU93042877 A RU 93042877A
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RU
Russia
Prior art keywords
cell
antibody
vector
identification
carrier
Prior art date
Application number
RU93042877/13A
Other languages
Russian (ru)
Inventor
Сид Брайан
Вальз Герд
Original Assignee
Дзе Дженерал Хоспитал Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Дженерал Хоспитал Корпорейшн filed Critical Дзе Дженерал Хоспитал Корпорейшн
Publication of RU93042877A publication Critical patent/RU93042877A/en

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Claims (1)

Раскрывается способ подавления связывания клетки, несущей белок адгезии клеток, с молекулой или клеткой, несущей углеводную детерминанту, специфичную для молекулы адгезии клеток. Этот способ заключается в контакте клетки, несущей белок адгезии клеток, с молекулой ингибитора, несущей углеводную детерминанту. Также раскрывается способ подавления связывания первого члена из пары специфического связывания с вторым членом пары специфического связывания, включающий контакт первого члена с антителом, специфичным для первого члена и ковалентно-связанным с углеводной частью, которая взаимодействует со способностью антитела фиксировать комплемент и связывать Fe рецептор. Способы изобретения можно применять, например, для уменьшения воспаления.A method for inhibiting the binding of a cell carrying a cell adhesion protein to a molecule or a cell carrying a carbohydrate determinant specific for a cell adhesion molecule is disclosed. This method consists in contacting a cell carrying a cell adhesion protein with an inhibitor molecule carrying a carbohydrate determinant. Also disclosed is a method of inhibiting the binding of the first member of a specific binding pair to the second member of a specific binding pair, comprising contacting the first member with an antibody specific for the first member and covalently linked to a carbohydrate moiety that interacts with the antibody's ability to fix complement and bind the Fe receptor. The methods of the invention can be used, for example, to reduce inflammation.
RU93042877/13A 1990-11-23 1991-11-18 METHOD FOR IDENTIFICATION OF ANTIBODY, ORGANIC MOLECULE, PHARMACEUTICAL COMPOSITION, NUCLEIC ACID, VECTOR, CELL, METHOD FOR PRODUCING A CARRIER RU93042877A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US618.314 1990-11-23

Publications (1)

Publication Number Publication Date
RU93042877A true RU93042877A (en) 1997-02-10

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