RU93037113A - DRUG FOR STIMULATION OF BONE TISSUE GROWTH - OSTIM-APATIT - Google Patents

DRUG FOR STIMULATION OF BONE TISSUE GROWTH - OSTIM-APATIT

Info

Publication number
RU93037113A
RU93037113A RU93037113/14A RU93037113A RU93037113A RU 93037113 A RU93037113 A RU 93037113A RU 93037113/14 A RU93037113/14 A RU 93037113/14A RU 93037113 A RU93037113 A RU 93037113A RU 93037113 A RU93037113 A RU 93037113A
Authority
RU
Russia
Prior art keywords
drug
ostim
stimulation
apatit
bone tissue
Prior art date
Application number
RU93037113/14A
Other languages
Russian (ru)
Other versions
RU2077329C1 (en
Inventor
В.Н. Рудин
В.Е. Божевольнов
В.П. Зуев
В.Ф. Комаров
И.В. Мелихов
В.В. Минаев
А.Ю. Орлов
А.С. Панкратов
А.А. Древаль
Original Assignee
В.Н. Рудин
В.Е. Божевольнов
В.П. Зуев
В.Ф. Комаров
И.В. Мелихов
В.В. Минаев
А.Ю. Орлов
А.С. Панкратов
А.А. Древаль
Filing date
Publication date
Application filed by В.Н. Рудин, В.Е. Божевольнов, В.П. Зуев, В.Ф. Комаров, И.В. Мелихов, В.В. Минаев, А.Ю. Орлов, А.С. Панкратов, А.А. Древаль filed Critical В.Н. Рудин
Priority to RU9393037113A priority Critical patent/RU2077329C1/en
Priority claimed from RU9393037113A external-priority patent/RU2077329C1/en
Priority to DE69413513T priority patent/DE69413513T2/en
Priority to EP94923110A priority patent/EP0664133B1/en
Priority to DK94923110T priority patent/DK0664133T3/en
Priority to PCT/RU1994/000151 priority patent/WO1995003074A1/en
Priority to AT94923110T priority patent/ATE171378T1/en
Priority to ES94923110T priority patent/ES2125470T3/en
Publication of RU93037113A publication Critical patent/RU93037113A/en
Application granted granted Critical
Publication of RU2077329C1 publication Critical patent/RU2077329C1/en

Links

Claims (1)

Сущность изобретения: изобретение относится к области медицины, а именно восстановительной костно-реконструктивной хирургии, хирургической стоматологии, травматологии и ортопедии. Предложен препарат для стимуляции роста костной ткани "Остим-апатит" на основе гидроксиапатита, его берут в виде водной пасты концентрацией 18-36 вес.% размером микрочастиц 0,015-0,16 мкм. Предложенный препарат на основе гидроксиапатита в отличие от всех существующих не является остеоконнектором. Препарат обладает фармакологическим действием за счет непосредственной стимуляции роста клеток костной ткани и характеризуется отсутствием отрицательных побочных эффектов.The inventive invention relates to the field of medicine, namely reconstructive bone reconstructive surgery, surgical dentistry, traumatology and orthopedics. A preparation is proposed for stimulating bone growth, Ostim-Apatite, based on hydroxyapatite, it is taken in the form of an aqueous paste with a concentration of 18-36 wt.% With a microparticle size of 0.015-0.16 microns. The proposed drug based on hydroxyapatite, unlike all existing ones, is not an osteoconnector. The drug has a pharmacological effect due to direct stimulation of bone cell growth and is characterized by the absence of negative side effects.
RU9393037113A 1993-07-21 1993-07-21 Agent for osseous tissue growth stimulation RU2077329C1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
RU9393037113A RU2077329C1 (en) 1993-07-21 1993-07-21 Agent for osseous tissue growth stimulation
DE69413513T DE69413513T2 (en) 1993-07-21 1994-07-14 OSTIM APATIT PREPARATION FOR PROMOTING GROWTH IN BONE TISSUE
EP94923110A EP0664133B1 (en) 1993-07-21 1994-07-14 Preparation "ostim apatite" for stimulating growth in bone tissue
DK94923110T DK0664133T3 (en) 1993-07-21 1994-07-14 "Ostim Apatit" preparation for stimulating bone growth
PCT/RU1994/000151 WO1995003074A1 (en) 1993-07-21 1994-07-14 Preparation 'ostim apatite' for stimulating growth in bone tissue
AT94923110T ATE171378T1 (en) 1993-07-21 1994-07-14 OSTIM APATIT PREPARATION FOR PROMOTING GROWTH IN BONE TISSUE
ES94923110T ES2125470T3 (en) 1993-07-21 1994-07-14 PREPARATION OF "OSTIM APATITE" FOR STIMULATION OF THE GROWTH OF THE OSEO TISSUE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU9393037113A RU2077329C1 (en) 1993-07-21 1993-07-21 Agent for osseous tissue growth stimulation

Publications (2)

Publication Number Publication Date
RU93037113A true RU93037113A (en) 1996-11-10
RU2077329C1 RU2077329C1 (en) 1997-04-20

Family

ID=20145359

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9393037113A RU2077329C1 (en) 1993-07-21 1993-07-21 Agent for osseous tissue growth stimulation

Country Status (7)

Country Link
EP (1) EP0664133B1 (en)
AT (1) ATE171378T1 (en)
DE (1) DE69413513T2 (en)
DK (1) DK0664133T3 (en)
ES (1) ES2125470T3 (en)
RU (1) RU2077329C1 (en)
WO (1) WO1995003074A1 (en)

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US6117456A (en) * 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US6953594B2 (en) 1996-10-10 2005-10-11 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
US7517539B1 (en) 1996-10-16 2009-04-14 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
DE69738398T2 (en) 1996-10-16 2008-12-04 Etex Corp., Cambridge BIOKERAMIC COMPOSITION
US8728536B2 (en) 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
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DE19816858A1 (en) 1998-04-16 1999-10-21 Merck Patent Gmbh Tricalcium phosphate-containing bio-cement pastes with cohesion promoters
DE19938704C1 (en) 1999-08-14 2001-10-31 Ivoclar Vivadent Ag Process for the production of reaction systems for implantation in the human and animal body as a bone substitute, which i.a. Contain calcium and phosphorus
DE19953771C1 (en) * 1999-11-09 2001-06-13 Coripharm Medizinprodukte Gmbh Absorbable bone implant material and method for producing the same
KR101161784B1 (en) 2003-04-11 2012-07-05 에텍스 코포레이션 Osteoinductive Bone Material
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EP1742648A4 (en) 2004-04-15 2009-03-04 Etex Corp Delayed-setting calcium phosphate pastes
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US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
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EP1958649A1 (en) 2007-02-14 2008-08-20 Graftys Injectable calcium-phosphate cement releasing a bone resorption inhibitor
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