RU93031251A - WATER-GLYCERINE COMPLEX (2,3-DIOXIPROPIN) -ORTO TITANATE HYDROCHLORIDE AND HELF-CONTAINING PHARMACEUTICAL COMPOSITION ON ITS BASIS - Google Patents
WATER-GLYCERINE COMPLEX (2,3-DIOXIPROPIN) -ORTO TITANATE HYDROCHLORIDE AND HELF-CONTAINING PHARMACEUTICAL COMPOSITION ON ITS BASISInfo
- Publication number
- RU93031251A RU93031251A RU93031251/04A RU93031251A RU93031251A RU 93031251 A RU93031251 A RU 93031251A RU 93031251/04 A RU93031251/04 A RU 93031251/04A RU 93031251 A RU93031251 A RU 93031251A RU 93031251 A RU93031251 A RU 93031251A
- Authority
- RU
- Russia
- Prior art keywords
- carrier
- water
- active substance
- hydrochloride
- temperature
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title claims 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 title claims 3
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 239000000969 carrier Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N n-butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 229940088623 Biologically Active Substance Drugs 0.000 claims 1
- 239000004166 Lanolin Substances 0.000 claims 1
- 229940039717 Lanolin Drugs 0.000 claims 1
- 239000004264 Petrolatum Substances 0.000 claims 1
- 229940066842 Petrolatum Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000005587 bubbling Effects 0.000 claims 1
- KKSAZXGYGLKVSV-UHFFFAOYSA-N butan-1-ol;titanium Chemical compound [Ti].CCCCO KKSAZXGYGLKVSV-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 239000004020 conductor Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 150000002484 inorganic compounds Chemical class 0.000 claims 1
- 229910010272 inorganic material Inorganic materials 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 235000019388 lanolin Nutrition 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 235000019271 petrolatum Nutrition 0.000 claims 1
- CMDGQTVYVAKDNA-UHFFFAOYSA-N propane-1,2,3-triol;hydrate Chemical compound O.OCC(O)CO CMDGQTVYVAKDNA-UHFFFAOYSA-N 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
- 239000010936 titanium Substances 0.000 claims 1
Claims (1)
MM 40209, плотность 25%-ного водного раствора 1,038 - 1,058, вязкость 1,40 - 2,80. Содержание титана 2,150 - 2,800. Содержание хлорид-иона 0,70 - 1,00, полученный взаимодействием глицерина с бутилортотитанатом при мольном соотношении 12: 1 соответственно, с отгонкой бутанола под вакуумом при температуре до 105oC не менее 3 ч с последующим барбатированием воздуха через реакционную массу при температуре до 30oC добавлением воды и соляной кислоты до pH 2,2 - 3,0; выдержкой массы при температуре до 95oC не более 2 ч. Предлагается также гелесодержащая фармацевтическая композиция, содержащая активное вещество и носитель, в качестве носителя - указанное соединение, а активное вещество может быть представлено любым лекарственным средством или биологически активным веществом при следующем соотношении компонентов, мас. %: активное вещество 0,01 - 10,00, носитель - остальное. С целью уменьшения расхода носителя композиция дополнительно может содержать разбавитель, выбранный из группы органических или неорганических соединений, таких как вазелин, ланолин, вода. Носитель - не менее 25 мас.%, остальное - разбавитель. Препарат и его композиции могут найти широкое применение в медицине для лечения различных заболеваний, а также в качестве транскутанного проводника.The invention relates to a new chemical compound of an unspecified structure, namely, a water-glycerin complex (2,3-dioxipropyl) -ortho titanate gross hydrochloride of the formula
MM 40209, the density of a 25% aqueous solution of 1.038 - 1.058, the viscosity of 1.40 - 2.80. Titanium content 2,150 - 2,800. The chloride ion content of 0.70 - 1.00, obtained by the interaction of glycerol with butylorthotitanate in a molar ratio of 12: 1, respectively, with distillation of butanol under vacuum at a temperature of up to 105 o C for at least 3 hours, followed by bubbling of air through the reaction mass at a temperature of up to 30 o With the addition of water and hydrochloric acid to a pH of 2.2 - 3.0; holding the mass at a temperature of up to 95 o C for no more than 2 hours. A gel-containing pharmaceutical composition containing an active substance and a carrier is also proposed, the specified compound is a carrier, and the active substance can be any drug or biologically active substance in the following ratio of components, wt. %: active substance 0.01 - 10.00, carrier - the rest. In order to reduce carrier consumption, the composition may further comprise a diluent selected from the group of organic or inorganic compounds, such as petrolatum, lanolin, water. The carrier is at least 25 wt.%, The rest is a diluent. The drug and its compositions can be widely used in medicine for the treatment of various diseases, as well as as a transcutaneous conductor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU93031251A RU2042683C1 (en) | 1993-06-23 | 1993-06-23 | Aqueous-glycerol complex (2,3-dihydroxypropyl)-ortho-titanate hydrochloride and pharmaceutical gel-containing composition on its basis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU93031251A RU2042683C1 (en) | 1993-06-23 | 1993-06-23 | Aqueous-glycerol complex (2,3-dihydroxypropyl)-ortho-titanate hydrochloride and pharmaceutical gel-containing composition on its basis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2042683C1 RU2042683C1 (en) | 1995-08-27 |
| RU93031251A true RU93031251A (en) | 1996-12-10 |
Family
ID=20143241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93031251A RU2042683C1 (en) | 1993-06-23 | 1993-06-23 | Aqueous-glycerol complex (2,3-dihydroxypropyl)-ortho-titanate hydrochloride and pharmaceutical gel-containing composition on its basis |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2042683C1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2635088C1 (en) * | 2016-09-15 | 2017-11-09 | Открытое акционерное общество "Уралбиофарм" | Titaniumorganic glycerogeland method of its production |
-
1993
- 1993-06-23 RU RU93031251A patent/RU2042683C1/en active
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