RU93027651A - METHOD FOR OBTAINING BENZIMIDAZOLES WITH THE HELP OF AN IMPROVED RESTORATIVE CYCLIZATION METHOD OF O-NITROANILIDES - Google Patents

METHOD FOR OBTAINING BENZIMIDAZOLES WITH THE HELP OF AN IMPROVED RESTORATIVE CYCLIZATION METHOD OF O-NITROANILIDES

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Publication number
RU93027651A
RU93027651A RU93027651/04A RU93027651A RU93027651A RU 93027651 A RU93027651 A RU 93027651A RU 93027651/04 A RU93027651/04 A RU 93027651/04A RU 93027651 A RU93027651 A RU 93027651A RU 93027651 A RU93027651 A RU 93027651A
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RU
Russia
Prior art keywords
nitroanilides
benzimidazoles
help
obtaining
cyclization
Prior art date
Application number
RU93027651/04A
Other languages
Russian (ru)
Inventor
Ю.В. Кузнецов
Л.Д. Смирнов
К.М. Дюмаев
Original Assignee
Товарищество с ограниченной ответственностью - Фирма "Брукс"
Filing date
Publication date
Application filed by Товарищество с ограниченной ответственностью - Фирма "Брукс" filed Critical Товарищество с ограниченной ответственностью - Фирма "Брукс"
Publication of RU93027651A publication Critical patent/RU93027651A/en

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Claims (1)

Изобретение относится к органической химии, а именно - к новым химическим технологиям, применяющимся в синтезе азотсодержащих гетероциклических соединений. Предлагается оптимизация процесса восстановительной циклизации о-нитроанилидов, заключающаяся в уменьшении в 5 раз времени реакции, увеличении выхода (более, чем в 1,5 раза) и чистоты конечного продукта - замещенного бензимидазола путем добавления рассчитанного количества смеси уксусной и соляной кислот к водному раствору о-нитроанилида, обработанному гидросульфитом натрия.The invention relates to organic chemistry, namely to new chemical technologies used in the synthesis of nitrogen-containing heterocyclic compounds. It is proposed to optimize the process of reductive cyclization of o-nitroanilides, which consists in reducing the reaction time by 5 times, increasing the yield (more than 1.5 times) and the purity of the final product - substituted benzimidazole by adding the calculated amount of a mixture of acetic and hydrochloric acids to an aqueous solution -nitroanilide, treated with sodium hydrosulfite.
RU93027651/04A 1993-05-13 METHOD FOR OBTAINING BENZIMIDAZOLES WITH THE HELP OF AN IMPROVED RESTORATIVE CYCLIZATION METHOD OF O-NITROANILIDES RU93027651A (en)

Publications (1)

Publication Number Publication Date
RU93027651A true RU93027651A (en) 1996-02-27

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