RU93005077A - OLIGONUCLOSIDE COMPOUNDS, INHIBITION METHODS, STABILIZATION METHOD, COMPOSITIONS - Google Patents

OLIGONUCLOSIDE COMPOUNDS, INHIBITION METHODS, STABILIZATION METHOD, COMPOSITIONS

Info

Publication number
RU93005077A
RU93005077A RU93005077/04A RU93005077A RU93005077A RU 93005077 A RU93005077 A RU 93005077A RU 93005077/04 A RU93005077/04 A RU 93005077/04A RU 93005077 A RU93005077 A RU 93005077A RU 93005077 A RU93005077 A RU 93005077A
Authority
RU
Russia
Prior art keywords
compositions
compounds
oligonucloside
stabilization method
inhibition methods
Prior art date
Application number
RU93005077/04A
Other languages
Russian (ru)
Other versions
RU2131436C1 (en
Inventor
Лювик Уэйс Александр
Германн Хошир Фредерик
Венката Чала Чатурведула Прасад
Джозеф Делеки Даниэль
Фрэнсис Каванауг Поль (младший)
Сюзан Москва Патрисия
Терри Оукс Фред
Original Assignee
Стерлинг Уинтроп, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Стерлинг Уинтроп, Инк. filed Critical Стерлинг Уинтроп, Инк.
Priority claimed from PCT/US1991/005531 external-priority patent/WO1992002534A2/en
Publication of RU93005077A publication Critical patent/RU93005077A/en
Application granted granted Critical
Publication of RU2131436C1 publication Critical patent/RU2131436C1/en

Links

Claims (1)

Предлагаемое изобретение относится к соединениям, композициям и методам ингибирования экспрессии генов. Предлагаемые соединения включают: олигонуклеозидные последовательности, состоящие из примерно 6 - 200 оснований, с трехатомной межнуклеозидной связью или олигонуклеотидные последовательности, состоящие из примерно 9 - 200 оснований с диолом у любого или обоих их концов.The present invention relates to compounds, compositions and methods for inhibiting gene expression. The proposed compounds include: oligonucleoside sequences consisting of about 6 to 200 bases, with a triatomic internucleoside linkage, or oligonucleotide sequences consisting of about 9 to 200 bases with a diol at either or both of their ends.
RU93005077A 1990-09-13 1991-08-02 Nuclease-resistant oligonucleosides, method of preparing thereof, and nuclease-resistant nucleoside dimer RU2131436C1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US562.180 1990-08-03
US58228790A 1990-09-13 1990-09-13
US58245790A 1990-09-13 1990-09-13
US582.457 1990-09-13
US582,457 1990-09-13
US582,287 1990-09-13
US582.287 1990-09-13
PCT/US1991/005531 WO1992002534A2 (en) 1990-08-03 1991-08-02 Compounds and methods for inhibiting gene expression

Publications (2)

Publication Number Publication Date
RU93005077A true RU93005077A (en) 1995-08-20
RU2131436C1 RU2131436C1 (en) 1999-06-10

Family

ID=27078532

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93005077A RU2131436C1 (en) 1990-09-13 1991-08-02 Nuclease-resistant oligonucleosides, method of preparing thereof, and nuclease-resistant nucleoside dimer

Country Status (1)

Country Link
RU (1) RU2131436C1 (en)

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