RU93004869A - NERVOUS MUSCLE BLOCKER, ITS PREPARATION, PHARMACEUTICAL COMPOSITION AND METHOD OF ENSURING NERVOUS MUSCLE BLOCKING ANIMALS - Google Patents
NERVOUS MUSCLE BLOCKER, ITS PREPARATION, PHARMACEUTICAL COMPOSITION AND METHOD OF ENSURING NERVOUS MUSCLE BLOCKING ANIMALSInfo
- Publication number
- RU93004869A RU93004869A RU93004869/14A RU93004869A RU93004869A RU 93004869 A RU93004869 A RU 93004869A RU 93004869/14 A RU93004869/14 A RU 93004869/14A RU 93004869 A RU93004869 A RU 93004869A RU 93004869 A RU93004869 A RU 93004869A
- Authority
- RU
- Russia
- Prior art keywords
- cis
- nervous muscle
- ensuring
- preparation
- pharmaceutical composition
- Prior art date
Links
- 230000000903 blocking Effects 0.000 title claims 2
- 210000003205 Muscles Anatomy 0.000 title 2
- 241001465754 Metazoa Species 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- NTYJJOPFIAHURM-UHFFFAOYSA-N histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000003287 optical Effects 0.000 claims 2
- -1 3,11-dioxo-4,10 dioxatridecylen Chemical class 0.000 claims 1
- 210000003403 Autonomic Nervous System Anatomy 0.000 claims 1
- 206010029315 Neuromuscular blockade Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229960001340 histamine Drugs 0.000 claims 1
- 230000002232 neuromuscular Effects 0.000 claims 1
- 230000001734 parasympathetic Effects 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 230000003578 releasing Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 230000002889 sympathetic Effects 0.000 claims 1
Claims (1)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9015473.3 | 1990-07-13 | ||
GB909015473A GB9015473D0 (en) | 1990-07-13 | 1990-07-13 | Neuromuscular blocking agents |
PCT/GB1991/001150 WO1992000965A1 (en) | 1990-07-13 | 1991-07-12 | Neuromuscular blocking agents |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93004869A true RU93004869A (en) | 1995-03-10 |
RU2104005C1 RU2104005C1 (en) | 1998-02-10 |
Family
ID=10679071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93004869A RU2104005C1 (en) | 1990-07-13 | 1991-07-12 | Nervous-muscle blockator, its synthesis, pharmaceutical composition and method of providing nervous-muscle blockade in animals |
Country Status (40)
Country | Link |
---|---|
EP (1) | EP0539470B1 (en) |
JP (3) | JP2823356B2 (en) |
KR (1) | KR0174284B1 (en) |
AT (1) | ATE138369T1 (en) |
AU (2) | AU8190491A (en) |
BE (1) | BE1003407A3 (en) |
CA (1) | CA2087104C (en) |
CH (1) | CH683427A5 (en) |
CY (1) | CY1985A (en) |
CZ (1) | CZ284645B6 (en) |
DE (2) | DE4191541T1 (en) |
DK (2) | DK0539470T3 (en) |
ES (2) | ES2088009T3 (en) |
FI (2) | FI103507B1 (en) |
FR (1) | FR2665701B1 (en) |
GB (2) | GB9015473D0 (en) |
GE (1) | GEP19981163B (en) |
GR (1) | GR3020792T3 (en) |
HK (1) | HK80196A (en) |
HU (2) | HU218766B (en) |
IE (1) | IE912440A1 (en) |
IL (1) | IL98814A (en) |
IT (1) | IT1249677B (en) |
LT (1) | LT3317B (en) |
LU (1) | LU88198A1 (en) |
LV (1) | LV10432B (en) |
MX (1) | MX9203220A (en) |
MY (1) | MY113017A (en) |
NL (1) | NL9120017A (en) |
NZ (1) | NZ238964A (en) |
PA (1) | PA8401801A1 (en) |
PL (1) | PL167302B1 (en) |
PT (1) | PT98306B (en) |
RU (1) | RU2104005C1 (en) |
SA (1) | SA91120073B1 (en) |
SE (1) | SE9300052D0 (en) |
SK (1) | SK279907B6 (en) |
UA (1) | UA32536C2 (en) |
WO (1) | WO1992000965A1 (en) |
ZA (1) | ZA915468B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5453510A (en) * | 1990-07-13 | 1995-09-26 | Burroughs Wellcome Co. | Neuromuscular blocking agents |
DE19535762A1 (en) * | 1995-09-26 | 1997-03-27 | Basf Ag | Racemate resolution process |
US5684154A (en) * | 1996-02-16 | 1997-11-04 | Abbott Laboratories | Process for the preparation and isolation of atracurium besylate |
CN1203061C (en) | 1997-03-25 | 2005-05-25 | 艾弗拉药品公司 | Substituted isoquinolines as ultra short acting neuromuscular blockers |
WO2008107887A2 (en) | 2007-03-08 | 2008-09-12 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
WO2008117271A1 (en) * | 2007-03-26 | 2008-10-02 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
EP2155684B1 (en) | 2007-05-01 | 2014-04-09 | Chemagis Ltd. | Process for producing cisatracurium compounds and associated intermediates |
EP2142510A1 (en) | 2007-05-01 | 2010-01-13 | Chemagis Ltd. | Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates |
US8357805B2 (en) * | 2007-06-18 | 2013-01-22 | Chemagis Ltd. | (1R,1′R)-atracurium salts separation process |
CN101337935B (en) * | 2007-07-06 | 2011-01-12 | 江苏恒瑞医药股份有限公司 | Method for purifying atracurium besylate by two-phase extraction |
CN101337936B (en) * | 2007-07-06 | 2011-03-23 | 江苏恒瑞医药股份有限公司 | Method for purifying atracurium besylate by column chromatography |
AU2008320380A1 (en) | 2007-10-29 | 2009-05-07 | Chemagis Ltd. | Novel R,R'-atracurium salts |
IT1396543B1 (en) * | 2008-07-16 | 2012-12-14 | Farmabios Spa | PROCESS FOR PURIFICATION OF NEUROMUSCULAR BLOCKS |
WO2010128518A2 (en) * | 2009-05-04 | 2010-11-11 | Gland Pharma Limited | Novel process for the preparation of cisatracurium besylate |
CN107056700A (en) * | 2017-04-18 | 2017-08-18 | 哈尔滨医科大学 | A kind of Resolution method of tetrahydroisoquinolicompounds compounds racemic modification |
CN112939862B (en) * | 2021-02-03 | 2023-01-10 | 江苏诚信药业有限公司 | Separation preparation method and application of cisatracurium besilate impurity H |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3004031A (en) * | 1958-07-03 | 1961-10-10 | Allen & Hauburys Ltd | Diquaternary salts of papaverino esters |
GB1579822A (en) * | 1976-10-29 | 1980-11-26 | Wellcome Found | Tetrahydroisoquinolinium muscle relaxants |
AU506657B2 (en) * | 1975-12-10 | 1980-01-17 | Wellcome Foundation Limited, The | Isoquinoline derivatives |
ES454090A1 (en) * | 1976-12-09 | 1978-01-16 | Wellcome Found | A method for preparing heterociclic compounds. (Machine-translation by Google Translate, not legally binding) |
DE3328664A1 (en) * | 1983-08-09 | 1985-02-21 | Robert Bosch Gmbh, 7000 Stuttgart | SUGAR DRAWER |
BG41897A1 (en) * | 1985-07-19 | 1987-09-15 | Ivanov | Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation |
-
1990
- 1990-07-13 GB GB909015473A patent/GB9015473D0/en active Pending
-
1991
- 1991-07-12 SK SK3833-92A patent/SK279907B6/en not_active IP Right Cessation
- 1991-07-12 WO PCT/GB1991/001150 patent/WO1992000965A1/en active IP Right Grant
- 1991-07-12 AT AT91913479T patent/ATE138369T1/en not_active IP Right Cessation
- 1991-07-12 EP EP91913479A patent/EP0539470B1/en not_active Expired - Lifetime
- 1991-07-12 ES ES91913479T patent/ES2088009T3/en not_active Expired - Lifetime
- 1991-07-12 RU RU93004869A patent/RU2104005C1/en active
- 1991-07-12 CZ CS923833A patent/CZ284645B6/en not_active IP Right Cessation
- 1991-07-12 IT ITRM910518A patent/IT1249677B/en active IP Right Grant
- 1991-07-12 HU HU9300052A patent/HU218766B/en unknown
- 1991-07-12 MY MYPI91001260A patent/MY113017A/en unknown
- 1991-07-12 BE BE9100665A patent/BE1003407A3/en not_active IP Right Cessation
- 1991-07-12 NZ NZ238964A patent/NZ238964A/en not_active IP Right Cessation
- 1991-07-12 IL IL9881491A patent/IL98814A/en not_active IP Right Cessation
- 1991-07-12 NL NL9120017A patent/NL9120017A/en not_active Application Discontinuation
- 1991-07-12 CH CH857/92A patent/CH683427A5/en not_active IP Right Cessation
- 1991-07-12 JP JP3512229A patent/JP2823356B2/en not_active Expired - Lifetime
- 1991-07-12 ES ES09250007A patent/ES2083315B1/en not_active Expired - Lifetime
- 1991-07-12 DK DK91913479.1T patent/DK0539470T3/en active
- 1991-07-12 DE DE19914191541 patent/DE4191541T1/en not_active Withdrawn
- 1991-07-12 AU AU81904/91A patent/AU8190491A/en not_active Abandoned
- 1991-07-12 PL PL91297606A patent/PL167302B1/en unknown
- 1991-07-12 IE IE244091A patent/IE912440A1/en not_active IP Right Cessation
- 1991-07-12 PT PT98306A patent/PT98306B/en not_active IP Right Cessation
- 1991-07-12 ZA ZA915468A patent/ZA915468B/en unknown
- 1991-07-12 KR KR1019930700072A patent/KR0174284B1/en not_active IP Right Cessation
- 1991-07-12 FR FR9108805A patent/FR2665701B1/en not_active Expired - Lifetime
- 1991-07-12 DE DE69119768T patent/DE69119768T2/en not_active Expired - Lifetime
- 1991-07-12 UA UA93101147A patent/UA32536C2/en unknown
- 1991-07-12 CA CA002087104A patent/CA2087104C/en not_active Expired - Fee Related
- 1991-08-18 SA SA91120073A patent/SA91120073B1/en unknown
-
1992
- 1992-06-24 MX MX9203220A patent/MX9203220A/en unknown
- 1992-11-26 GB GB9224764A patent/GB2260763B/en not_active Expired - Lifetime
- 1992-12-09 LU LU88198A patent/LU88198A1/en unknown
- 1992-12-14 DK DK921496A patent/DK149692D0/en not_active Application Discontinuation
- 1992-12-18 LV LVP-92-334A patent/LV10432B/en unknown
- 1992-12-28 FI FI925894A patent/FI103507B1/en not_active IP Right Cessation
- 1992-12-30 LT LTIP274A patent/LT3317B/en not_active IP Right Cessation
-
1993
- 1993-01-12 SE SE9300052A patent/SE9300052D0/en not_active Application Discontinuation
- 1993-07-26 GE GEAP19931161A patent/GEP19981163B/en unknown
-
1995
- 1995-01-23 AU AU11346/95A patent/AU687481B2/en not_active Expired
- 1995-05-12 HU HU95P/P00131P patent/HU211169A9/en unknown
-
1996
- 1996-05-09 HK HK80196A patent/HK80196A/en not_active IP Right Cessation
- 1996-08-14 GR GR960402172T patent/GR3020792T3/en unknown
- 1996-11-14 PA PA19968401801A patent/PA8401801A1/en unknown
-
1997
- 1997-09-05 CY CY198597A patent/CY1985A/en unknown
- 1997-09-08 JP JP9242598A patent/JPH10139763A/en active Pending
-
1998
- 1998-10-28 FI FI982342A patent/FI982342A/en unknown
-
2000
- 2000-09-05 JP JP2000268819A patent/JP3462165B2/en not_active Expired - Lifetime
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