RU93004779A - DERIVATIVES OF PEPTIDES AND THEIR THERAPEUTICALLY ACCEPTABLE SALTS, METHOD FOR PRODUCING THEREOF, PHARMACEUTICAL AND COSMETIC COMPOSITION, METHOD FOR TREATING INFECTIOUS VIRUSES WITH HERPES VIRUS - Google Patents

DERIVATIVES OF PEPTIDES AND THEIR THERAPEUTICALLY ACCEPTABLE SALTS, METHOD FOR PRODUCING THEREOF, PHARMACEUTICAL AND COSMETIC COMPOSITION, METHOD FOR TREATING INFECTIOUS VIRUSES WITH HERPES VIRUS

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Publication number
RU93004779A
RU93004779A RU93004779/14A RU93004779A RU93004779A RU 93004779 A RU93004779 A RU 93004779A RU 93004779/14 A RU93004779/14 A RU 93004779/14A RU 93004779 A RU93004779 A RU 93004779A RU 93004779 A RU93004779 A RU 93004779A
Authority
RU
Russia
Prior art keywords
derivatives
peptides
pharmaceutical
producing
acceptable salts
Prior art date
Application number
RU93004779/14A
Other languages
Russian (ru)
Inventor
Десьель Робер
МОСС Нил
Плант Раймонд
Original Assignee
Био-Мега/Берингер Ингельгейм Рисерч Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Био-Мега/Берингер Ингельгейм Рисерч Инк. filed Critical Био-Мега/Берингер Ингельгейм Рисерч Инк.
Publication of RU93004779A publication Critical patent/RU93004779A/en

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Claims (1)

Предлагаются производные пептидов формулы A-Б-NHCH-{CH2C(O) R1}-C(O)-NHCH-{ CR2 (R3)COOH}-C(O)-B, где A - концевая группа, например алкиламинокарбонил или фенилалкиламинокарбонил; Б - остаток аминокислоты; R1 - алкил, циклоалкил или дизамещенная аминогруппа; R2 - водород или алкил и R3 - алкил, или R2 - водород и R3 - фенилалкил, или R2 и R3 вместе образуют циклоалкил; B - концевая группа, например алкиламиногруппа, или одновалентный радикал аминокислоты, например NHCH (алкил) C(O)OH. Эти вещества являются эффективными средствами для лечения заражений герпесом. Предлагаются также способ получения указанных производных пептидов, а также фармацевтическая и косметическая композиции, содержащие эти соединения, и способ лечения заражений герпесом с применением этих соединений.Derivatives of peptides of the formula A-B-NHCH- {CH 2 C (O) R 1 } -C (O) -NHCH- {CR 2 (R 3 ) COOH} -C (O) -B, where A is an end group for example alkylaminocarbonyl or phenylalkylaminocarbonyl; B — amino acid residue; R 1 is alkyl, cycloalkyl or a disubstituted amino group; R 2 is hydrogen or alkyl and R 3 is alkyl, or R 2 is hydrogen and R 3 is phenylalkyl, or R 2 and R 3 together form cycloalkyl; B is an end group, for example, an alkylamino group, or a monovalent amino acid radical, for example, NHCH (alkyl) C (O) OH. These substances are effective in treating herpes infections. Also provided are a method for producing said peptide derivatives, as well as pharmaceutical and cosmetic compositions containing these compounds, and a method for treating herpes infections using these compounds.
RU93004779/14A 1992-03-12 1993-03-12 DERIVATIVES OF PEPTIDES AND THEIR THERAPEUTICALLY ACCEPTABLE SALTS, METHOD FOR PRODUCING THEREOF, PHARMACEUTICAL AND COSMETIC COMPOSITION, METHOD FOR TREATING INFECTIOUS VIRUSES WITH HERPES VIRUS RU93004779A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US849,922 1992-03-12

Publications (1)

Publication Number Publication Date
RU93004779A true RU93004779A (en) 1997-01-10

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