RU93004779A -
DERIVATIVES OF PEPTIDES AND THEIR THERAPEUTICALLY ACCEPTABLE SALTS, METHOD FOR PRODUCING THEREOF, PHARMACEUTICAL AND COSMETIC COMPOSITION, METHOD FOR TREATING INFECTIOUS VIRUSES WITH HERPES VIRUS
- Google Patents
DERIVATIVES OF PEPTIDES AND THEIR THERAPEUTICALLY ACCEPTABLE SALTS, METHOD FOR PRODUCING THEREOF, PHARMACEUTICAL AND COSMETIC COMPOSITION, METHOD FOR TREATING INFECTIOUS VIRUSES WITH HERPES VIRUS
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RU93004779A
RU93004779ARU93004779/14ARU93004779ARU93004779ARU 93004779 ARU93004779 ARU 93004779ARU 93004779/14 ARU93004779/14 ARU 93004779/14ARU 93004779 ARU93004779 ARU 93004779ARU 93004779 ARU93004779 ARU 93004779A
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Application filed by Био-Мега/Берингер Ингельгейм Рисерч Инк.filedCriticalБио-Мега/Берингер Ингельгейм Рисерч Инк.
Publication of RU93004779ApublicationCriticalpatent/RU93004779A/en
Предлагаются производные пептидов формулы A-Б-NHCH-{CH2C(O) R1}-C(O)-NHCH-{ CR2 (R3)COOH}-C(O)-B, где A - концевая группа, например алкиламинокарбонил или фенилалкиламинокарбонил; Б - остаток аминокислоты; R1 - алкил, циклоалкил или дизамещенная аминогруппа; R2 - водород или алкил и R3 - алкил, или R2 - водород и R3 - фенилалкил, или R2 и R3 вместе образуют циклоалкил; B - концевая группа, например алкиламиногруппа, или одновалентный радикал аминокислоты, например NHCH (алкил) C(O)OH. Эти вещества являются эффективными средствами для лечения заражений герпесом. Предлагаются также способ получения указанных производных пептидов, а также фармацевтическая и косметическая композиции, содержащие эти соединения, и способ лечения заражений герпесом с применением этих соединений.Derivatives of peptides of the formula A-B-NHCH- {CH 2 C (O) R 1 } -C (O) -NHCH- {CR 2 (R 3 ) COOH} -C (O) -B, where A is an end group for example alkylaminocarbonyl or phenylalkylaminocarbonyl; B — amino acid residue; R 1 is alkyl, cycloalkyl or a disubstituted amino group; R 2 is hydrogen or alkyl and R 3 is alkyl, or R 2 is hydrogen and R 3 is phenylalkyl, or R 2 and R 3 together form cycloalkyl; B is an end group, for example, an alkylamino group, or a monovalent amino acid radical, for example, NHCH (alkyl) C (O) OH. These substances are effective in treating herpes infections. Also provided are a method for producing said peptide derivatives, as well as pharmaceutical and cosmetic compositions containing these compounds, and a method for treating herpes infections using these compounds.
RU93004779/14A1992-03-121993-03-12
DERIVATIVES OF PEPTIDES AND THEIR THERAPEUTICALLY ACCEPTABLE SALTS, METHOD FOR PRODUCING THEREOF, PHARMACEUTICAL AND COSMETIC COMPOSITION, METHOD FOR TREATING INFECTIOUS VIRUSES WITH HERPES VIRUS
RU93004779A
(en)
DERIVATIVES OF PEPTIDES AND THEIR THERAPEUTICALLY ACCEPTABLE SALTS, METHOD FOR PRODUCING THEREOF, PHARMACEUTICAL AND COSMETIC COMPOSITION, METHOD FOR TREATING INFECTIOUS VIRUSES WITH HERPES VIRUS
Peptide derivatives with ureide group at n termination exhibiting antiherpetic activitty, method of obtaining them, pharmaceutical and cosmetic containing these compounds and method of retarding replication of herpes viruses