RU93004574A - CYCLOSPORINS, METHOD OF THEIR PRODUCTION AND A PHARMOCOMPOSITION ON THEIR BASIS - Google Patents
CYCLOSPORINS, METHOD OF THEIR PRODUCTION AND A PHARMOCOMPOSITION ON THEIR BASISInfo
- Publication number
- RU93004574A RU93004574A RU93004574/13A RU93004574A RU93004574A RU 93004574 A RU93004574 A RU 93004574A RU 93004574/13 A RU93004574/13 A RU 93004574/13A RU 93004574 A RU93004574 A RU 93004574A RU 93004574 A RU93004574 A RU 93004574A
- Authority
- RU
- Russia
- Prior art keywords
- cyclosporins
- pharmocomposition
- basis
- production
- amino
- Prior art date
Links
- 108010036941 Cyclosporins Proteins 0.000 title claims 2
- 208000006673 Asthma Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Claims (1)
где -x-y- является -CH=CH- (транс) или -CH2-CH2-, Х - 0 или S, а R - водородом, необязательно галоид- или гидроксизамещенным C1 - 3-алкилом, -алкокси или -алкилтио, или амино или моно- или ди-( С1 - 2 - алкил)-амино, можно использовать в качестве лекарств, в частности для лечения астмы.Cyclosporins, in which the residue in position 1 has the formula
wherein -xy- is -CH = CH- (trans) or -CH 2 -CH 2 -, X - 0 or S, and R - hydrogen, optionally halo- or hydroxy-substituted C 1 - 3 -alkyl, -alkoxy or -alkylthio , or amino or mono- or di- (C 1 - 2 - alkyl) -amino, can be used as drugs, in particular for the treatment of asthma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929204466A GB9204466D0 (en) | 1992-03-02 | 1992-03-02 | Improvements in or relating to organic compounds |
GB9204466.8 | 1992-03-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93004574A true RU93004574A (en) | 1996-05-10 |
RU2131883C1 RU2131883C1 (en) | 1999-06-20 |
Family
ID=10711333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93004574A RU2131883C1 (en) | 1992-03-02 | 1993-03-01 | Derivatives of cyclosporin, method of their synthesis and pharmaceutical composition based on said |
Country Status (26)
Country | Link |
---|---|
US (1) | US5643870A (en) |
EP (1) | EP0577544B1 (en) |
JP (1) | JP3382656B2 (en) |
KR (1) | KR100256988B1 (en) |
CN (1) | CN1037104C (en) |
AT (1) | ATE146484T1 (en) |
AU (1) | AU667072B2 (en) |
CA (1) | CA2090634C (en) |
CZ (1) | CZ285421B6 (en) |
DE (1) | DE69306670T2 (en) |
DK (1) | DK0577544T3 (en) |
ES (1) | ES2096262T3 (en) |
FI (1) | FI111729B (en) |
GB (1) | GB9204466D0 (en) |
GR (1) | GR3022539T3 (en) |
HU (1) | HU214028B (en) |
IL (1) | IL104891A (en) |
MX (1) | MX9301129A (en) |
MY (1) | MY106921A (en) |
NO (1) | NO310685B1 (en) |
NZ (1) | NZ247031A (en) |
PL (1) | PL174816B1 (en) |
RU (1) | RU2131883C1 (en) |
SK (1) | SK279529B6 (en) |
TW (1) | TW264472B (en) |
ZA (1) | ZA931491B (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5639852A (en) * | 1994-09-01 | 1997-06-17 | Wisconsin Alumni Research Foundation | Immunostimulatory agents |
CN1130373C (en) * | 1996-09-13 | 2003-12-10 | 诺瓦蒂斯有限公司 | Production process |
US6517860B1 (en) | 1996-12-31 | 2003-02-11 | Quadrant Holdings Cambridge, Ltd. | Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery |
ATE314388T1 (en) | 1997-10-08 | 2006-01-15 | Isotechnika Inc | DEUTERATED AND UNDEUTERATED CYCLOSPORINE ANALOGAS AND THEIR USE AS IMMUNOMODULATING AGENTS |
US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
US6784156B2 (en) * | 2001-03-05 | 2004-08-31 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of respiratory diseases |
US6809077B2 (en) * | 2001-10-12 | 2004-10-26 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogs for the treatment of autoimmune diseases |
US20030087813A1 (en) * | 2001-10-12 | 2003-05-08 | Or Yat Sun | Cyclosporin analogs for the treatment of lung diseases |
SI1436321T1 (en) | 2001-10-19 | 2006-12-31 | Isotechnika Inc | Synthesis of cyclosporin analogs |
US7012065B2 (en) * | 2003-02-07 | 2006-03-14 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of immune disorders |
EP1603512A2 (en) * | 2003-03-17 | 2005-12-14 | Albany Molecular Research, Inc. | Novel cyclosporins |
US20040266669A1 (en) * | 2003-06-20 | 2004-12-30 | Wu Frank X. H. | Cyclosporin derivatives for the treatment of immune disorders |
JP2006014722A (en) | 2004-06-02 | 2006-01-19 | Keio Gijuku | Gene marker and its use |
JP2008514701A (en) * | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | Cyclosporine alkyne analogs and their pharmaceutical use |
US7511013B2 (en) * | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
JP2008515886A (en) * | 2004-10-06 | 2008-05-15 | エーエムアール テクノロジー インコーポレイテッド | Cyclosporine alkynes and their usefulness as medical drugs |
EP1814902B1 (en) * | 2004-11-22 | 2008-10-22 | Astellas Pharma Inc. | Cyclosporine analogue |
US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
EP2197461B1 (en) | 2007-10-08 | 2018-02-21 | Aurinia Pharmaceuticals Inc. | Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors |
AU2009276241A1 (en) * | 2008-07-30 | 2010-02-04 | Ciclofilin Pharmaceuticals Corp. | Nonimmunosuppressive cyclosporine analogue molecules |
ES2537385T3 (en) | 2009-06-09 | 2015-06-08 | Aurinia Pharmaceuticals Inc. | Topical supply systems for ophthalmic use |
US20130267460A1 (en) * | 2010-09-16 | 2013-10-10 | The Johns Hopkins University | Methods of Inhibiting Alphavirus Replication and Treating Alphavirus Infection |
US9200038B2 (en) | 2010-12-15 | 2015-12-01 | Ciclofilin Pharmaceuticals Corp. | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
CN105076117B (en) * | 2014-10-31 | 2017-08-25 | 北京林业大学 | A kind of seed age resister and preparation method thereof |
KR20170000243U (en) | 2015-07-09 | 2017-01-18 | (주)하나피앤씨 | Apparatus For Flange For Connecting Pipes |
US9981041B2 (en) * | 2016-08-23 | 2018-05-29 | Ira Jason Salzman | Ophthalmic lubricating spray |
US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2819094A1 (en) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | CYCLOSPORIN DERIVATIVES, THEIR USE AND MANUFACTURING |
EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
US4649047A (en) * | 1985-03-19 | 1987-03-10 | University Of Georgia Research Foundation, Inc. | Ophthalmic treatment by topical administration of cyclosporin |
US4764503A (en) * | 1986-11-19 | 1988-08-16 | Sandoz Ltd. | Novel cyclosporins |
EP0283801A3 (en) * | 1987-03-27 | 1990-05-30 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies |
US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
ATE95193T1 (en) * | 1987-06-17 | 1993-10-15 | Sandoz Ag | CYCLOSPORINS AND THEIR USE AS MEDICINAL PRODUCTS. |
US4839342A (en) * | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
CA2004626A1 (en) * | 1988-12-05 | 1990-06-05 | Bernard F. Erlanger | Derivatives of cyclosporine a, antibodies directed thereto and uses thereof |
US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
GB8916901D0 (en) * | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
US5202310A (en) * | 1990-06-06 | 1993-04-13 | Levy Gary A | Cyclosporine metabolites |
EP0484281B2 (en) * | 1990-11-02 | 2000-11-22 | Novartis AG | Cyclosporins |
-
1992
- 1992-03-02 GB GB929204466A patent/GB9204466D0/en active Pending
-
1993
- 1993-02-16 HU HU9300418A patent/HU214028B/en not_active IP Right Cessation
- 1993-02-22 EP EP93810113A patent/EP0577544B1/en not_active Expired - Lifetime
- 1993-02-22 AT AT93810113T patent/ATE146484T1/en not_active IP Right Cessation
- 1993-02-22 ES ES93810113T patent/ES2096262T3/en not_active Expired - Lifetime
- 1993-02-22 DE DE69306670T patent/DE69306670T2/en not_active Expired - Fee Related
- 1993-02-22 DK DK93810113.6T patent/DK0577544T3/en active
- 1993-02-26 US US08/023,525 patent/US5643870A/en not_active Expired - Lifetime
- 1993-02-26 SK SK140-93A patent/SK279529B6/en not_active IP Right Cessation
- 1993-02-26 MY MYPI93000352A patent/MY106921A/en unknown
- 1993-02-27 KR KR1019930002881A patent/KR100256988B1/en not_active IP Right Cessation
- 1993-03-01 MX MX9301129A patent/MX9301129A/en unknown
- 1993-03-01 PL PL93297902A patent/PL174816B1/en not_active IP Right Cessation
- 1993-03-01 NO NO19930738A patent/NO310685B1/en not_active IP Right Cessation
- 1993-03-01 FI FI930912A patent/FI111729B/en active
- 1993-03-01 NZ NZ247031A patent/NZ247031A/en not_active IP Right Cessation
- 1993-03-01 JP JP03983793A patent/JP3382656B2/en not_active Expired - Fee Related
- 1993-03-01 CN CN93102101A patent/CN1037104C/en not_active Expired - Fee Related
- 1993-03-01 CZ CZ93303A patent/CZ285421B6/en not_active IP Right Cessation
- 1993-03-01 IL IL104891A patent/IL104891A/en not_active IP Right Cessation
- 1993-03-01 AU AU33872/93A patent/AU667072B2/en not_active Ceased
- 1993-03-01 CA CA002090634A patent/CA2090634C/en not_active Expired - Fee Related
- 1993-03-01 RU RU93004574A patent/RU2131883C1/en active
- 1993-03-02 ZA ZA931491A patent/ZA931491B/en unknown
- 1993-03-03 TW TW082101559A patent/TW264472B/zh active
-
1997
- 1997-02-12 GR GR970400227T patent/GR3022539T3/en unknown
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