RU93004471A - PIPERIDILOXY- AND HINUCLIDINYLOXY-ISOXASOL DERIVATIVES AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS - Google Patents

PIPERIDILOXY- AND HINUCLIDINYLOXY-ISOXASOL DERIVATIVES AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS

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Publication number
RU93004471A
RU93004471A RU93004471/04A RU93004471A RU93004471A RU 93004471 A RU93004471 A RU 93004471A RU 93004471/04 A RU93004471/04 A RU 93004471/04A RU 93004471 A RU93004471 A RU 93004471A RU 93004471 A RU93004471 A RU 93004471A
Authority
RU
Russia
Prior art keywords
piperidiloxy
hinuclidinyloxy
isoxasol
derivatives
basis
Prior art date
Application number
RU93004471/04A
Other languages
Russian (ru)
Other versions
RU2079496C1 (en
Inventor
Нагано Митсуо
Сакаи Джунити
Кобаяси Такео
Козука Масао
Цвата Нобуеси
Кубо Есико
Original Assignee
Санкио Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Санкио Компани Лимитед filed Critical Санкио Компани Лимитед
Publication of RU93004471A publication Critical patent/RU93004471A/en
Application granted granted Critical
Publication of RU2079496C1 publication Critical patent/RU2079496C1/en

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Claims (1)

Соединения формулы (I)
Figure 00000001
в которой R1 является водородом, галогеном или алкилом; R2 является водородом, алкилом, необязательно замещенным фенилом или гетероциклом; R1 и R2 вместе образуют группу формулы -CR4= CR5-CR6= CR7-, где R4, R5, R6 и R7 являются водородом, галогеном, алкильной группой, алкокси-, галоидметилом, алкиламино-, диалкиламино-, гидрокси-, нитро-, алифатической карбоксильной ациламино или аминогруппой; R3 является пиперидилом, замещенным пиперидилом или хинуклидинилом, полезными при лечении и профилактике расстройств познавательной способности, особенно старческого слабоумия, включая болезнь Алзхеймера.The compounds of formula (I)
Figure 00000001
in which R 1 is hydrogen, halogen or alkyl; R 2 is hydrogen, alkyl, optionally substituted phenyl or heterocycle; R 1 and R 2 together form a group of the formula -CR 4 = CR 5 -CR 6 = CR 7 -, where R 4 , R 5 , R 6 and R 7 are hydrogen, halogen, alkyl, alkoxy, halomethyl, alkylamino- dialkylamino, hydroxy, nitro, aliphatic carboxylic acylamino or amino group; R 3 is piperidyl, substituted piperidyl or quinuclidinyl, useful in the treatment and prevention of cognitive disorders, especially senile dementia, including Alzheimer's disease.
RU9393004471A 1990-05-11 1993-02-09 Piperidylhydroxy- or quinuclidinylhydroxy-isoxazole derivatives or their pharmaceutically acceptable salts, composition decreasing cognitive function disorders RU2079496C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2-119754 1990-05-11
JP11975490 1990-05-11
JP2-216519 1990-08-17
JP21651990 1990-08-17
JP2-278489 1990-10-17

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU4895403 Division

Publications (2)

Publication Number Publication Date
RU93004471A true RU93004471A (en) 1995-10-27
RU2079496C1 RU2079496C1 (en) 1997-05-20

Family

ID=26457428

Family Applications (2)

Application Number Title Priority Date Filing Date
SU4895403 RU2017737C1 (en) 1990-05-11 1991-05-08 Method of isoxazole derivatives synthesis
RU9393004471A RU2079496C1 (en) 1990-05-11 1993-02-09 Piperidylhydroxy- or quinuclidinylhydroxy-isoxazole derivatives or their pharmaceutically acceptable salts, composition decreasing cognitive function disorders

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SU4895403 RU2017737C1 (en) 1990-05-11 1991-05-08 Method of isoxazole derivatives synthesis

Country Status (1)

Country Link
RU (2) RU2017737C1 (en)

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