RU92004474A - DERIVATIVES OF AMINO ACIDS - Google Patents
DERIVATIVES OF AMINO ACIDSInfo
- Publication number
- RU92004474A RU92004474A RU92004474/04A RU92004474A RU92004474A RU 92004474 A RU92004474 A RU 92004474A RU 92004474/04 A RU92004474/04 A RU 92004474/04A RU 92004474 A RU92004474 A RU 92004474A RU 92004474 A RU92004474 A RU 92004474A
- Authority
- RU
- Russia
- Prior art keywords
- derivatives
- amino acids
- mixtures
- formula
- blood pressure
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title 1
- 206010007554 Cardiac failure Diseases 0.000 claims 2
- 206010019280 Heart failure Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108090000783 Renin Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000000875 corresponding Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 230000001131 transforming Effects 0.000 claims 1
Claims (1)
где X, R1, R2,R3,R4,R5 имеют указанное значение в форме оптически чистых диастереомеров, смесей диастереомеров, диастереомерных рацематов или смесей диатереомерных рацематов и их применяемых в фармации солей, тормозящих действие природного фермента ренин и их можно, следовательно, применять в форме фармацевтических препаратов при борьбе с высоким кровяным давлением и сердечной недостаточностью или при предупреждении высокого кровяного давления и сердечной недостаточности. Их можно получать превращением аминодиола формулы (II)
с соответствующей кислотой или с ее активированным производным.The proposed compounds of formula (I)
where X, R 1 , R 2 , R 3 , R 4 , R 5 have the indicated value in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diathereomeric racemates and their salts used in pharmacy that inhibit the action of the natural enzyme renin therefore, be used in the form of pharmaceuticals in the fight against high blood pressure and heart failure, or in the prevention of high blood pressure and heart failure. They can be obtained by transformation of the aminodiol of formula (II)
with the corresponding acid or with its activated derivative.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH3374/91 | 1991-11-19 | ||
| CH2665/92 | 1992-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU92004474A true RU92004474A (en) | 1995-08-20 |
Family
ID=
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