RU781U1 - Device for biomedical treatment of biological systems - Google Patents

Abstract

1. A device for biomedical processing of biological systems, containing a radiation unit with a system for generating radiation parameters, including a pulse generator, characterized in that the radiation unit includes one or more laser emitters, and the system for generating radiation parameters is equipped with low-frequency and high-frequency frequency dividers matching circuit, switching unit, frequency control unit, power level control unit and pulse shaping unit, while the operating inputs are low frequency and high-frequency dividers are connected to a pulse generator, their control inputs are connected to the corresponding outputs of the frequency control unit, and the working outputs of the low-frequency and high-frequency frequency dividers are connected via a matching circuit and are directly connected to the working inputs of the switching unit, the control input of which is connected to the first output of the control unit power level, and the output with the first input of the pulse forming unit, the second input of which is connected to the control output of the high-frequency elitelya frequency, wherein the control output of the control unit is connected to the input frequency of the power level control unit, the second output of which is connected to a second control input of the high frequency divider chastoty.2. The device according to claim 1, characterized in that it has a permanent magnet of an annular shape, and the laser emitter is placed in a cylindrical chamber with an axial hole for the passage of the light flux, while the permanent magnet is mounted on the body of the cylindrical chamber coaxially with its axial hole, and the opposite �

Description

A6I No. 5/06

DEVICE FOR MEDICAL AND BIOLOGICAL PROCESSING OF BIOLOGICAL SYSTEMS

The utility model relates to medical equipment and can be used in the sweeping areas of medicine for laser and magnetic laser effects on biological objects in therapy, surgery, traumatology, reflexology, neuralgia, dentistry, oncology, etc., as well as for the treatment of liquid media: blood, plasma and their substitutes, growth media and voluminous medicines.

A device for biomedical treatment of biological systems is known, comprising a radiation unit with a radiation parameter generation system including a pulse generator. (See V.E. Illarionov Fundamentals of Laser Therapy, M., Respect, 1992, pp. 19-36).

However, the known device for biomedical treatment of biological systems does not have a sufficient range of possible effects on biological systems, does not allow you to change, vary the parameters of the impact during processing, to carry out combined effects and, therefore, does not provide the necessary therapeutic effect when exposed to the human body and biological effect when exposed to liquid media and preparations.

The use of a device declared as a useful model for biomedical biological systems biological treatment provides a wide range of exposure parameters for biological systems, allows varying exposure parameters during processing and has a combined effect

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and thus ca№w helps to accelerate the treatment process and increase its effectiveness in the treatment of diseases, and when processing liquid media and drugs provides the desired biological effect.

The processing efficiency is increased if, when several laser emitters are used in the process of biomedical processing, the pulses of their action are coordinated in phase and frequency. Laser radiation, modulated in frequency, in addition to giving the biological system a certain energy, carries an informative effect at the cellular level. Laser radiation with the same parameters (power, wavelength, etc.), but sent to a biological object with different the pulse repetition rate has a different effect on it, since it tells the cells different information (it programs them differently). For example, the biostimulation effect observed at a frequency of 80 Hz is explained by the fact that the frequency at which cell division occurs at 77.77 ... Hz. Thus, when an object is exposed to pulses of laser radiation with a frequency of 80 Hz, the cell is programmed as if to divide and, as a result, the wounds heal quickly, etc.

Processing efficiency is increased, the duration of the process is reduced if, simultaneously with exposure to laser radiation, the object is exposed to a constant or alternating magnetic field and / or ultraviolet radiation. combined effect, the therapeutic effect of the impact in the treatment of a number of diseases and leads to a reduction in treatment time.

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using a device for biomedical processing of biological systems, comprising a radiation unit with a radiation parameter generation system including a pulse generator, in which the radiation unit includes one or more laser emitters, and the radiation parameter generation system is provided with low-frequency and high-frequency frequency dividers, matching circuit, the unit, the switching unit, the frequency control unit, the power level control unit and the pulse shaping unit, while the operating inputs are low frequency and high-frequency dividers are connected to a pulse generator, their control inputs are connected to the corresponding outputs of the frequency control unit, and the working outputs of the low-frequency and high-frequency frequency dividers are connected via a matching circuit and are directly connected to the working inputs of the switching unit, the control input of which is connected to the first output of the control unit power level, and the output with the first input of the pulse forming unit, the second input of which is connected to the control output of the high-frequency a frequency divider, and the control output of the frequency control unit is connected to the input of the power level control unit, the second output of which is connected to the second control input of the high-frequency frequency divider.

One of the possible embodiments of the device is one in which it has a repeated magnet of a ring-shaped shape, and the laser emitter is placed in a cylindrical chamber with an axial hole for the passage of the light flux, while the permanent magnet is mounted on the body of the cylindrical space, measures coaxially with its axial hole, and the outer wall of the chamber opposing it is equipped with a holder.

The treatment process is ensured by the fact that, in this embodiment, the device has a light flux focusing system located between the permanent magnet and the laser emitter, and a set of optical fibers.

With a combined exposure to a magnetic field and laser radiation, the biomedical effect of the treatment increases, the efficiency increases, and the treatment time is reduced. This result is achieved by using a modification of the device, which is equipped with a permanent magnet made in the form of a disk or ring, and the laser emitters that make up the radiation unit are oriented in one direction, while the permanent magnet is installed behind the laser emitters of the radiation unit.

The use of several laser emitters in the radiation unit allows you to cover a large surface of the object during processing, and also to affect the object with laser radiation in different modes simultaneously, for example, in continuous and pulsed modes and in their various time combinations, sequence and intensity.

A special case of the implementation of the device of this modification is one in which the laser emitters of the radiation unit are located uniformly in the plane of the circle with a diameter equal to the diameter of a permanent magnet.

Particular cases of the implementation of the device are those in which the permanent magnet is made with radial or axial magnetization.

A higher uniformity of the magnetic field compared with a modification of the device in which the magnet has axial magnetization has a variant of its implementation in which the permanent magnet is made of interconnected side faces of individual sectors with radial magnetization.

Another possible modification of the device is one in which the permanent magnet is made in the form of a disk with axial magnetization and interconnected by lateral faces of sectors with radial magnetization, along the arcs of its smaller bases conjugated with the generatrix of the disk, which ensures the creation of a stronger magnetic field.

The convenience of using the device is enhanced if the laser emitter housing is equipped with a holder.

The holder can be made hollow, in this case it can be used to supply external communications (current supply) of the device.

The therapeutic effect of a number of diseases is enhanced, their treatment time is reduced with combined laser and / or magnetic laser irradiation of objects in combination with exposure to the object with ultraviolet radiation. To ensure this result, the device is supplied with a source of ultraviolet radiation.

The essence of the utility model is illustrated by graphic materials.

On Fig, 1,2,3,4,5 shows various modifications of the device for biomedical treatment of biological systems.

In FIG. b is a block diagram of a system for generating radiation parameters.

On Fig, 7.8 shows tactograms explaining the operation of the system for the formation of radiation parameters.

A device for biomedical treatment of biological systems includes a radiation unit, which can be made in the form of one or more laser emitters I, When using several laser emitters I in the radiation unit, the latter are grouped into matrices (Figs. 1, 2, 5), creating a total laser radiation.

The matrix may contain from 10 to 30 laser emitters I, which are oriented in the direction of the processed object.

The processed objects can be in a static position, for example, in the treatment of diseases of people or animals, when the radiation unit is positioned relative to any of their organs, in the treatment of liquid media or preparations, for example, blood placed in a vessel 2 (Fig. 1) for collection donated blood to be preserved.

Processed objects can be in motion (see figure 2) when the processed liquid medium is pumped through: through the treatment zone, which is carried out in a flat cuvette 3. System 4 (see figure 1) for generating radiation parameters provides the necessary character of the effect on the object , setting and varying the parameters of laser radiation, choosing the mode of exposure, matching the phase and frequency of the pulses of exposure to laser radiation.

In addition to laser radiation, the object can be exposed to a magnetic field, which is created by means of a permanent magnet 5, which can be made in the form of a disk or ring (Fig. 1,2,5) or have only an annular shape (Fig. 3 and 4). The shape of the permanent magnet 5 is determined by the design features of the laser emitter.

Permanent magnets 5 are interchangeable. The change of permanent magnets 5, you can change the intensity of exposure to the object with a magnetic field, the biological and medical effect of exposure to a magnetic field is different when the polarity of the magnet is changed.

In addition to laser and magnetic laser effects, the object can be exposed to ultraviolet radiation, which can be carried out using the emitter 6 of ultraviolet radiation (figure 2).

Laser emitters I are housed in housings 7 of non-magnetic material.

In one of the possible modifications of the device, the housing 7 is made in the form of a cylindrical camera (Fig. 3,4), having an axial hole 8 for passing the light flux of the laser radiation.

A permanent magnet 5 of an annular shape is fixed on the housing of the cylindrical chamber coaxially to the axial hole of the chamber. Outer wall of the chamber opposite to the axial hole 8 is equipped with a holder 9.

When used in the processing of optical fibers (not shown in the drawings), the device is equipped with an optical system 10 for focusing the light flux located between the permanent magnet 5 and the laser emitter I (Fig. 4).

The radiation parameter generation system 4 includes (Fig. 6) a pulse generator 10 connected to the working inputs of a low-frequency divider II and a high-frequency divider 12. The control inputs of the frequency dividers II and 12 are connected to the outputs of the frequency control unit 13, and the operational outputs of the frequency dividers II and 12 are connected to the inputs of the matching circuit 14 and to the operational inputs of the switching unit 15. The output of the matching circuit 14 is connected to the third working input of the switching unit 15, the control input of which is connected to the first output of the power level control unit 16. The output of the switching unit 15 is connected to the first input of the pulse forming unit 17, the second input of which is connected to the control output of the high-frequency frequency divider 12. The output of the frequency control unit 13 is connected to the input of the power level control unit 16, the second output of which is connected to the second control input of the high-frequency frequency divider 12, the outputs of the pulse generating unit 17 are connected to the radiation units.

A device for biomedical processing of biological systems operates as follows.

The object to be processed is placed (FigL) or fed (Fig.2) to the irradiation zone. During medical treatment (treatment) of a person, the device is positioned relative to the organs or parts of the body being treated (Fig. 3 and 5), and in cases of exposure to hard-to-reach, including internal organs, access to them and exposure is carried out using optical fibers (Fig. 4) .

After that, the object is exposed to laser radiation with predetermined parameters, which are determined based on the nature of the disease, treatment recommendations, the characteristics of the medium being treated, the drug, etc.

The exposure to laser radiation is carried out by means of one (Fig. 3,4) or several (Fig. 1,2,5) laser emitters I.

The impact on the object is carried out continuously or in a pulsed mode with a pulse duration of from 50 to 100 not.

When using several laser emitters I, the impact on the object can be carried out simultaneously in continuous and pulsed modes.

Exposure to a magnetic field by means of permanent magnets 5 and / or ultraviolet radiation by means of an ultraviolet radiation source b can be carried out simultaneously with laser irradiation or in a different sequence.

The task and changing the parameters of the laser radiation, the coordination of the phase and frequency of the pulsed action is carried out through the system 4 of the formation of radiation parameters.

The functioning of the system 4 of the formation of radiation parameters is as follows.

NEW II and high-frequency 12 frequency dividers with different Qt and Kg respectively division factors. Obtained as a result of dividing the various frequency signals from the outputs of the dividers P and 12 frequencies are fed to the inputs of the matching circuit 14 and to the inputs of the switching unit 15. The signal from the output of the matching circuit 14 is supplied to the third working input of the switching unit 15, which connects one of these three signals to the pulse forming unit 17 by the command coming from the power level control unit 16.

Values of Kt and Kp division factors for divisors II and

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12 frequencies are set by the unit. 13 frequency control. Corresponding information from the frequency control unit 13 is also supplied to the power level control unit 16, which in turn can correct the value of K and thereby affect the frequency of the signal at the output of the high-frequency frequency divider 12.

The priority in controlling the division ratio K has a block

13 frequency control, when the output of the switching unit 15 is necessary to obtain a sequence of single high-frequency pulses. At the same time, at the input of the pulse forming unit 17, the switching unit 15 supplies a signal from the output of the high-frequency frequency divider 12 (point B in FIG. B). The priority in controlling the division ratio K has the power level control unit 16, when the signal from the coincidence circuit 14 must be supplied to the input of the pulse generating unit 17 (through the switching unit 15),

In the initial state, according to the signal from the power level control unit 16, the switching unit 15 supplies the input from the output of the low-frequency divider II frequency to the input of the power generating unit 17. In this case, low-frequency pulses follow with a frequency

- / 3-

The value of the dividing coefficient Km is set by the frequency control unit 13, based on the desired value of the frequency of the laser radiation generated by the radiation units I, taking into account the possible limit values set for the low-frequency divider II frequency (for example, from O to 1500 Hz). If the required frequency lies above this limit, then it is set using the frequency control unit 13, changing the division coefficient K of the high-frequency frequency divider 12.

In this case, the switching unit 15 disconnects the output of the low-frequency frequency divider II from the input of the pulse-forming unit 17, and connects the corresponding output of the high-frequency frequency divider 12 to the pulse-forming unit 17. Thus, using the frequency control unit 13, it is possible to set the desired repetition rate of single pulses in the range O −f 100000 Hz.

So, for example, the frequency control unit 13 sets the desired frequency of 100 Hz, which is fed to the input of the pulse forming unit 17. In this case, single pulses of optical radiation with a frequency of 100 Hz will be obtained at the outputs of blocks I of radiation. For pulsed lasers having a rather high 10-W GW per Pulse and a fixed radiation pulse duration of 70 T150 nes, the average power will be 0.08 I m W, which is insufficient for most cases of processing biosystems with laser radiation. With an increase in average power due to an increase in impulse power, the biosystem is damaged at the cellular level (cell rupture, etc.). An increase in average power due to an increase in the duration of and; the pulse is also not possible, since this leads to the failure of laser emitters I.

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to the output of the high-frequency 12 divider), to widely control the average power (in this case, from 0, m W to 40,460 m W).

To obtain pulse packets using block 16 control the power level change the division ratio Kg.

At the same time, the switching unit 15 switches the input of the pulse forming unit 17, connecting it to the output of the matching circuit 14 (point C of FIG. 6). At the same time .. at the input of the pulse generation unit 17, pulse packets with a frequency of 100 Hz appear, and the pulse repetition rate in the packets can vary from 400 Hz to 100,000 Hz. The power level control unit 16 sets the required for. this value K.

Thus, either a sequence of single pulses or pulse packets is supplied to the first input of the pulse generating unit 17.

At its first exit, along the front of the incoming pulse, pulses of constant duration are formed. At the second exit from the incoming pulses along the front, pulses are formed, which in shape are mea, tsr. This output is used to start the laser emitters I in the continuous mode of radiation. Moreover, the amplitude of the output pulses is proportional to the radiation power. The magnitude of the amplitude is directly proportional to the frequency at the output of the high-frequency 12 frequency divider.

Thus, with an increase in the frequency at the output of the high-frequency 12 frequency divider, along with an increase in the average power of the pulsed radiation, the average power (continuous radiation power) of the laser emitters of the first radiation unit, operating in the continuous mode, starting according to the second

the output of the pulse forming unit 17. In the particular case of the implementation of the present invention, the frequency dividers II and 12 can be digital counters, which provide a division of the input frequency by a specified division ratio. The frequency at the output of the divider f

So, for example, by setting the division coefficient K, in the general case, from a fixed frequency coming from a pulsed 10 generator (100,000 Hz), it is possible to obtain signals with different frequencies in the range from 0 to 100,000 Hz at the output of the dividers P and 12. The low-frequency divider of the II frequency operates in the range of 041500 Hz. A high frequency divider 12 frequency provides an output signal with a higher frequency up to 100000 Hz.

The frequency dividers P and 12 can work both alternately, generating single pulses in the frequency range from tenths of a hertz to hundreds of kilohertz, and together. In the latter case, laser radiation is modulated at two frequencies: low and high, which is precisely what leads to the formation of a packet of pulses of different densities.

If a low frequency, for example 80 Hz, at which the pronounced effect of biostimulation, wound healing, etc., is observed, is fixed, and a high frequency is changed within 400 Hz to 50,000 Hz, then it is possible not only to adjust within narrow limits

average radiation power and change the information code of the impact on the biosystem, but also get additional effects of anesthesia at frequencies of 1500 Hz, ZOOO-bOOO Hz, 24000 Hz, 30,000 Hz.

In the radiation units, various semiconductor laser emitters with a wavelength of 0.67 μm - 1.331 μm, matrix or single ones, operating in continuous or pulsed mode with a duration of 50 nf-1000 not for pulse emitters up to several seconds for continuous emitters, can be used powerfully i (}

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from milliwatts to hundreds of watts per pulse.

The operation of the device is illustrated by the tactograms of FIG. 7 and. 8, which illustrate the nature and sequence of the signals generated by the system 4 and, therefore, the nature of the effect of laser radiation on biological systems.

The values of the division coefficients Kj and K are set for low-frequency II and high-frequency 12 frequency dividers, based on the ratio

-, 4, - where KJ and Кр are integers.

K i: s

The following are possible examples of using the claimed utility models.

Example I. The use of utility models is possible in an ambulance when it is necessary to quickly improve the patient's condition: relieve pain, normalize blood pressure, etc., for a wide variety of injuries and diseases. Moreover, what kind of impact will most effectively depend on the specific case. In some cases, it is necessary to act with continuous radiation from a certain distant wave, in others it is most efficient to emit a pulsed laser at a high frequency in combination with the south pole of the magnet, in third it is necessary to process radiation over a large area and it is best to use radiation units with matrices of several tens of laser blocks of radiation, in the fourth - it is enough to influence biologically active points or carry out intravenous irradiation of blood. An additional convenience of work is also due to the fact that the entire device, together with radiation units and magnetic nozzles, is placed in a standard automotive pharmacy.

processing donated blood before canning in order to extend the shelf life of blood. Due to the fact that several laser emitters can work simultaneously, a high productivity of the device is achieved.

Claims (10)

1. A device for biomedical processing of biological systems, containing a radiation unit with a system for generating radiation parameters, including a pulse generator, characterized in that the radiation unit includes one or more laser emitters, and the system for generating radiation parameters is equipped with low-frequency and high-frequency frequency dividers matching circuit, switching unit, frequency control unit, power level control unit and pulse shaping unit, while the operating inputs are low frequency and high-frequency dividers are connected to a pulse generator, their control inputs are connected to the corresponding outputs of the frequency control unit, and the working outputs of the low-frequency and high-frequency frequency dividers are connected via a matching circuit and are directly connected to the working inputs of the switching unit, the control input of which is connected to the first output of the control unit power level, and the output with the first input of the pulse forming unit, the second input of which is connected to the control output of the high-frequency elitelya frequency, wherein the control output unit is connected to the frequency control input of the power level control unit, the second output of which is connected to a second control input of the high-frequency frequency divider. 2. The device according to claim 1, characterized in that it has a permanent magnet of a ring-shaped shape, and the laser emitter is placed in a cylindrical chamber with an axial hole for the passage of the light flux, while the permanent magnet is mounted on the housing of the cylindrical chamber coaxially with its axial hole, and opposing the outer wall of the camera is equipped with a holder. 3. The device according to claim 2, characterized in that it has a light flux focusing system located between the permanent magnet and the laser emitter, and a set of optical fibers. 4. The device according to claim 1, characterized in that it is equipped with a permanent magnet made in the form of a disk or ring, and the laser emitters that make up the radiation unit are oriented in one direction, while the permanent magnet is installed behind the laser emitters of the radiation unit. 5. The device according to claim 4, characterized in that the laser emitters of the radiation unit are arranged uniformly in the plane of the circle with a diameter equal to the diameter of the permanent magnet. 6. The device according to claim 2 or 4, characterized in that the permanent magnet is made with radial or axial magnetization. 7. The device according to claim 2 or 4, characterized in that the permanent magnet is made of interconnected side faces of individual sectors with radial magnetization. 8. The device according to claims 4 and 5, characterized in that the permanent magnet is made in the form of a disk with axial magnetization and interconnected by lateral faces of sectors with radial magnetization, along the arcs of its smaller bases conjugated with the generatrix of the disk surface. 9. The device according to claim 4, characterized in that the laser emitter body is equipped with a holder. 10. The device but PP.1 and 4, characterized in that it has a source of ultraviolet radiation.