RU73778U1 - MACHINE FOR FIXING SMALL LABORATORY ANIMALS - Google Patents

Abstract

The utility model relates to the field of experimental medicine and veterinary medicine. The proposed machine for fixing small laboratory animals includes a rectangular frame formed by two bearing longitudinal perforated strips and two transverse elements, which are also supporting elements of the machine. One of the supporting elements of the machine is a corner made of perforated aluminum. Another supporting element is a bracket. Perforated aluminum strips are attached to the ends of the bracket. The supporting elements are represented by three perforated aluminum strips connecting the supporting strips, as well as a transversely perforated aluminum plate fixed to the supporting strips in approximately their middle part. Elements for fixing the animal are made in the form of duralumin clamps equipped with adjusting screws, mounted on two transverse strips and a plate. The attachment of perforated aluminum strips to the bracket, as well as the attachment of the bracket, corner, transverse strips and plates to the bearing strips, is carried out using screw connections. The advantages of the proposed device in relation to the prototype: compact design - the machine is specially designed for fixing small laboratory animals - mice and rats; low weight of the machine; the ability to arbitrarily change the angle of the machine; the ability to change the length and width of the machine depending on the individual characteristics of the animal; the possibility of reliable fixation of the animal to the machine; excluded conditions for the occurrence of necrotization of limb tissues.

Description

The utility model relates to the field of experimental medicine and veterinary medicine.

A device for fixing the spine of an animal or human is known (EP 1842504). This device is designed to fix only the spine.

A device is known (EP 1842504 A1) for fixing the limbs of an animal; a device for fixing the head of an animal (US 4, 620, 540); device for fixing small laboratory animals (Schupp E, Bekemeier H. A. fixation form for rats and other small laboratory animals / Z Versuchstierkd. 1973; 15 (5): 290-6. PMID: 4779676.

A device for fixing animals is described in the patent "Method for experimental modeling of general controlled hyperthermia in small laboratory animals" (RF patent No. 2165105, prototype). This machine contains a frame measuring 150 mm × 200 mm made of a metal pipe with a diameter of 15 mm. The machine-supporting elements of the machine are made of pieces of wire 5 mm in diameter welded to the short sides of the frame. The supporting elements of the machine are represented by four legs, also made of a pipe with a diameter of 15 mm. At the same time, the parts of the legs (30 mm) protrude above the surface of the frame, for which the animal is fixed on the machine. The front legs of the machine are shorter than the rear, the frame is fixed to the legs at an angle of 60 degrees with respect to them. To prevent corrosion, the fixing machine is coated with paint.

However, this device has a number of disadvantages in use:

1) the bulkiness of the structure (the machine is much larger than

required for fixing small laboratory animals (mice and rats) and a large mass;

2) the lack of the ability to arbitrarily change the angle of inclination of the machine;

3) the inability to change the length of the machine depending on the individual characteristics of the animal;

4) the impossibility of reliable fixation of the animal to the machine. When using the prototype machine, the animal is stretched beyond the limbs and fixed to the upper ends of the machine legs with gauze ties. A rat or mouse can gnaw through the gauze tie, or the tie may loose spontaneously, especially when operating the machine in a liquid environment;

5) when using the prototype machine, necrotic tissue of the animal’s limbs was often noted above the place of its fixation with gauze.

Disclosure of the proposed utility model

The proposed machine for fixing small laboratory animals includes a rectangular frame formed by two bearing longitudinal perforated strips and two transverse elements attached to their ends, which are also supporting elements of the machine. One of the supporting elements of the machine is a corner made of perforated aluminum. Another supporting element is a bracket. Perforated aluminum strips are attached to the bent ends of the bracket. The angle of inclination of the strips to the curved ends of the bracket can be changed using the mount. The supporting elements are represented by three transversely arranged perforated aluminum strips fixed to the bearing strips between their ends, as well as a transversely arranged perforated aluminum plate fixed to the bearing strips in approximately their middle part. Elements for fixing the animal are made in the form of

adjusting screws of duralumin clamps mounted on two transverse strips and a plate. Using the adjusting screws, you can arbitrarily change the diameter of the clamps to adapt them to the size of the body of a particular animal.

The attachment of perforated aluminum strips to the bracket, as well as the attachment of the bracket, corner, transverse strips and plates to the bearing strips, is carried out using screw connections.

Frame dimensions: the length of the short sides (corner and bracket) is 40-70 mm, the long sides (bearing strips) are 180-250 mm.

The advantages of the proposed device in relation to the prototype:

1) compact design - the machine is specially designed for fixing small laboratory animals - mice and rats;

2) a small mass of the machine;

3) the ability to arbitrarily change the angle of inclination of the machine;

4) the ability to change the length and width of the machine depending on the individual characteristics of the animal;

5) the possibility of reliable fixation of the animal to the machine;

6) the conditions for the occurrence of necrotization of limb tissues are excluded.

The list of figures illustrative material.

Figure 1 - photograph of a machine for fixing small laboratory animals: 1 - bearing aluminum strips; 2 - transversely arranged aluminum strips; 3 - clamps; 4 - aluminum plate; 5 - bracket with aluminum strips attached to its ends; 6 - corner.

Figure 2 is a drawing of a machine for fixing small laboratory animals (the designation of the machine elements in numbers is similar to that indicated in figure 1).

Figure 3 - comparative dimensions of the machine and small laboratory animal

Figure 4 - the rat is fixed in the machine. The machine is fixed by an arm over the edge of the thermal bath.

Figure 1, 2 shows a photograph and a drawing of the proposed machine. The machine contains a rectangular frame, the long sides of which are formed by two bearing perforated aluminum strips. The short sides of the frame are the supporting elements of the machine. One of the supporting elements located in the lower part of the machine is made in the form of a corner. Another support element located in the upper part of the machine is a bracket - a perforated aluminum strip with bent ends. Short aluminum strips are attached to these ends with screws, the angle of inclination of which to the ends of the bracket can be changed depending on what the bracket is attached to, what position in space we want to give the machine.

To maintain the body of the animal, the machine is equipped with three aluminum strips (for example, 50 mm long, 10 mm wide) attached transversely to the bearing strips, and one wide plate (for example, 50 mm long and 30 mm wide), which serves to prevent loss of the body of the animal from the machine). The plate is attached transversely to the bearing strips in about their middle part. To fix the animal in the machine, there are three duralumin clamps with a variable diameter attached to two transverse strips and a plate. Each clamp is equipped with an adjusting screw, allowing quick installation of the required diameter, depending on the individual characteristics of the animal.

Perforation pitch of strips and plate (distance between centers

holes in all aluminum elements of the machine) amounted to 10 mm, but it may be different.

The proposed machine is a modular design - its device allows you to increase and reduce the number of structural elements of the machine when working with large specimens of small laboratory animals due to the perforation holes on the aluminum plates, which allows you to add / remove structural elements of the machine.

The technique of operation of the machine.

Having placed the animal in the machine, using the screwdriver set the desired diameter of the clamps, which ensures reliable fixation of the animal in the machine. Fixation of the animal with clamps is performed in the neck, in the iliac region and in the pelvic area. Then fix the bracket of the machine for any suitable stop for fixing the machine. After that, it is possible to conduct directly the experimental part of the study.

Claims (1)

A machine for fixing small laboratory animals, including a rectangular frame, supporting supporting elements and elements for fixing the animal on the machine, characterized in that the frame is formed by two bearing longitudinal perforated strips and two transverse elements attached to their ends, which are also supporting elements of the machine, one of which is a corner made of perforated aluminum, and the other is a bracket with perforated aluminum strips attached to its bent ends, supporting digits together represent the three elements disposed transversely perforated aluminum strips attached to the support strip between their ends, and transversely extending perforated aluminum plate fixed to the support strip approximately in the middle part thereof; elements for fixing the animal are made in the form of duralumin clamps equipped with adjusting screws, mounted on two transverse strips and a plate; moreover, the attachment of perforated aluminum strips to the bracket, as well as the attachment of the bracket, corner, transverse strips and plates to the bearing strips is carried out using screw connections.