RU61556U1 - ENZYME IMMUNOMODULATING ANTIBACTERIAL PERFORATIVE ATRAUMATIC ADHESIVE PLASTER - Google Patents

Abstract

The utility model relates to medicine, namely to purulent surgery. The device contains a textile towel 10 cm long and 5 cm wide, which has a depot system of a drug and a biocompatible polymer. Holes were made on the napkin over its entire area; it was fixed on a medical adhesive plaster 10 cm long and 7 cm wide, on which holes were made in the depot zone. The depot system additionally contains the drug Wobenzym. The use of the proposed product affects the production of interferon, activation of local immunity, improves microcirculation, which ensures an increase in the concentration of antibiotics in the focus of infection, reduces the healing time of the wound due to the active discharge of exudate through the perforated openings of the tissue and adhesive plaster, reduces the toxicity of antibacterial drugs, increases the antibacterial, anti-inflammatory , decongestant, fibrinolytic effect. 1 ave. 2 ill.

Description

The utility model relates to medicine, namely to purulent surgery and serves for local treatment of wounds.

In the treatment of patients with extensive and long non-healing wounds, various types of dressings are used. Currently, many types of dressings and plasters have been developed: the bactericidal adhesive plaster "S-plast" and the bactericidal adhesive plaster of Novosibkhimpharm OJSC and others (catalogs of dressings of Biotekfarm CJSC, Novosibkhimpharm OJSC).

The prototype of the proposed product is the medical dressing material "Activtex HF" (T. Vasilyeva, Biologically active textile dressings "Activtex" // Materials of the 4th international conference "Modern approaches to the development and clinical use of effective dressings, suture materials and polymer implants" . - Moscow, November 27-28, 2001 - S.105-106).

Significant disadvantages of the above funds are trauma to the wound surface during dressings due to displacement of the dressing, insufficient bactericidal, anti-inflammatory, regenerative effect, multi-stage dressing.

The technical result is an increase in the effectiveness of treatment, a reduction in the healing time, an increase in the discharge of exudate.

Figure 1 shows a napkin and adhesive tape with holes, figure 2 is a General view of the proposed device.

The proposed product is a medical dressing material - textile napkin 1 with a length of 10 cm and a width of 5 cm with additional holes 2 over its entire area, containing a depot system 3 with a biocompatible polymer, an antibacterial drug and

a preparation consisting of a combination of natural enzymes (enzymes) WOBENZIM, dissolved in a 0.9% aqueous solution of sodium chloride. The napkin is glued on a medical adhesive plaster 4 with a length of 10 cm and a width of 7 cm with pre-punched holes 5 in the area of the depot system. On the front adhesive surface of the adhesive patch there is a protective film (Fig.1-2).

The proposed product is used as follows: during dressings, the wound surface is washed with an antiseptic. A protective film is removed from the adhesive plaster. On the prepared adhesive plaster, 10 cm long and 7 cm wide with perforated holes, dressing material "Activetex HF" is glued 10 cm long and 5 cm wide with additional perforated holes. Prepared product before use, in the field of glued dressing "Activetex HF". it is impregnated with a biocompatible polymer, an antibacterial drug, a drug from a combination of natural enzymes VOBENZIM, dissolved in a 0.9% aqueous solution of sodium chloride. The proposed product is applied to the wound. Dressings are carried out as perforated holes become contaminated.

The object of our study was 40 people. The main group was bandaged wounds using the proposed tool. Wobenzym has an anti-inflammatory, fibrinolytic effect, improves microcirculation, which ensures an increase in the concentration of antibiotics in the focus of infection. At the same time, it increases the sensitivity of microorganisms to antibiotics, reduces their toxic effect and activates the production of interferon.

25 patients made up the main group, which performed the dressings of the proposed tool.

15 patients made up the control group, which performed dressings with the means adopted for the prototype.

When comparing clinical results in the main and control groups, the following results were noted:

Based on the results of the application of the proposed product in the main group, high antibacterial, fibrinolytic, regenerative, anti-inflammatory properties were identified. Also, due to the production of interferon, due to the activation of immunity, an active discharge of exudate through additionally made perforated holes on a napkin was noted.

Studies have shown that the use of Activetex HF dressings in combination with the WOBENZIM preparation affects the production of interferon, the activation of local immunity, improves microcirculation, which increases the concentration of antibiotics in the focus of infection, reduces the healing time of the wound due to the active discharge of exudate through perforated hole wipes and adhesive tape, reduces the toxicity of antibacterial drugs, increases antibacterial, anti-inflammatory, anti edema, fibrinolytic action. The difference in healing in the main and control groups was 5 days.

Clinical example: Patient B., 45 years old. Entered with an infected left hip wound. Diagnosis - Scalpated infected wound of the left leg in the thigh. The defect area was 5 × 6 cm. The treatment was carried out using dressings using the proposed product. The bandaging frequency was 1 time in two days as the perforated holes became dirty. Held 5 dressings. As the wound was ligated, it was cleaned in a short time due to local production of interferon, activation of immunity, and additionally made perforated holes on a napkin. The wound granulated with a decrease in the area of the skin defect. Wound epithelization occurred in a short time. The healing of a skin defect with the formation of a scar was 8-10 days.

The inventive perforated medical adhesive plaster was used in bandaging in 25 patients with long-term non-healing wounds. The duration of wound epithelization was 8-10 days. Thus, the results of clinical studies show that the proposed product has an effect on the production of interferon, activation of local immunity, improves microcirculation, it provides an increase in the concentration of antibiotics in the focus of infection, reduces the healing time of the wound due to the active discharge of exudate through the perforated openings of the tissue and adhesive patch, reduces toxicity of antibacterial drugs, increases antibacterial, anti-inflammatory, decongestant and fibrinolytic effects .

Claims (1)

A means for dressing long-term non-healing wounds, containing a textile towel 10 cm long and 5 cm wide, which has a depot system of the drug and biocompatible polymer, characterized in that the holes are made over the entire area of the tissue, and it is fixed on a 10 cm medical adhesive plaster and a width of 7 cm, on which openings are made in the zone of the depot system, and the depot system further comprises a Wobenzym preparation.