RU2821015C1 - New clothianidin compositions and methods of use thereof - Google Patents

Abstract

FIELD: agriculture.

SUBSTANCE: invention relates to a pesticide composition. Stable pesticide composition is characterized by content of 10 to 60% wt./wt. of clothianidin, from 1 to 10% wt./wt. of graft copolymer, from 0.1 to 10% wt./wt. of acrylic-type copolymer having a backbone containing an ethylenically unsaturated carboxylated monomer and an ethylenically unsaturated non-carboxylated monomer, from 0.1 to 10% wt./wt. of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer with average molecular weight from 4,950 to 6,500 and content of hydrophilic part from 30 to 50% by weight and content from 10 to 87.8% wt./wt. water. Stable pesticide composition can additionally contain one or more additional additives. Stable pesticide composition is used in the pest control method by applying the composition to the area to be protected from pests. Preferred pest is aphid or wireworm.

EFFECT: disclosed stable pesticide composition has improved rheological properties, is stable during storage in a wide range of temperatures, has high efficiency with respect to the target pest.

6 cl, 5 tbl, 3 ex

Description

TECHNICAL FIELD

[1] The present invention relates to a pesticide composition comprising clothianidin, a graft copolymer, an acrylic (acrylic type) copolymer having a backbone containing a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer, and optionally a poly(ethylene oxide)-poly block copolymer (propylene oxide)-poly(ethylene oxide) with an average molecular weight of from about 4950 to about 6500 and a hydrophilic moiety content of from about 30% to about 50% by weight. The present invention also relates to a pest control method comprising applying a composition according to the present invention to an area to be protected from pests.

BACKGROUND OF THE ART

[2] Arthropod pests, including insects and mites, are major threats to human well-being, pose ongoing pressure on food supplies, and transmit a wide range of medical and veterinary diseases. Insect pests can cause serious and costly damage to crops, ornamental plants and food supplies. In addition, insects and mites transmit disease to humans and from person to person, resulting in reduced life expectancy, decreased quality of life, and increased medical costs.

[3] Aphids are pests of cultivated plants that cause many problems and cause great economic losses. Approximately 250 species of aphids have been described and feed on crops, trees and ornamental plants. Aphids feed on plant nectar, which leads to reduced growth rates, low yields and death. Aphids are also vectors of a variety of microscopic plant pathogens that transmit disease from plant to plant. Aphid control measures include the use of synthetic pesticides and the use of natural predators. Although aphids have many natural enemies, such as ladybugs and parasitic wasps, predators and parasitoids alone are not effective in preventing aphid damage to crops. Unfortunately, aphids have also developed resistance to many common pesticides.

[4] Another insect pest that causes great economic damage is the wireworm. Wireworms feed mainly on herbaceous crops. Wireworm infestation can cause severe crop damage. Wireworms are especially destructive to corn. Wireworm infestation of corn often leads to large crop losses.

[5] Clothianidin is available as an active ingredient in NipsIt INSIDE®. NipsIt INSIDE® is a registered trademark seed treatment that contains 47.8% (w/w) clothianidin and is available from Valent U.S.A. LLC. NipsIt INSIDE® has proven effective against aphids and wireworms. However, NipsIt INSIDE® has a short shelf life.

[6] Accordingly, there is a need in the art for a stable composition of clothianidin.

BRIEF DESCRIPTION OF THE INVENTION

[7] The present invention relates to a pesticide composition comprising clothianidin, a graft copolymer, an acrylic (acrylic type) copolymer having a backbone containing a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer, and optionally a poly(ethylene oxide)-poly block copolymer (propylene oxide)-poly(ethylene oxide) with an average molecular weight of from about 4950 to about 6500 and a hydrophilic moiety content of from about 30% to about 50% by weight.

[8] The present invention also relates to a pest control method comprising applying a composition according to the present invention to an area to be protected from pests.

DETAILED DESCRIPTION OF THE INVENTION

[9] The applicant has discovered a unique mixture of surfactants capable of forming a shelf-stable clothianidin composition.

[10] In one embodiment, the present invention provides a pesticide composition comprising clothianidin, a graft copolymer, an acrylic (acrylic-type) copolymer having a backbone comprising a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer, and a poly(ethylene oxide) block copolymer. -poly(propylene oxide)-poly(ethylene oxide) with an average molecular weight of from about 4950 to about 6500 and a hydrophilic moiety content of from about 30% to about 50% by weight.

[11] In a preferred embodiment, the present invention relates to a pesticide composition comprising:

from about 10% to about 60% (w/w) clothianidin;

from about 1% to about 10% (w/w) graft copolymer;

from about 0.1% to about 10% (wt/wt) acrylic (acrylic type) copolymer having a backbone containing a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer;

optionally, from about 0.1% to about 10% (w/w) of a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer having an average molecular weight of 4950 and a hydrophilic moiety content of 30% by weight.

[12] In a more preferred embodiment, the present invention provides a composition comprising:

about 47.8% (w/w) clothianidin;

about 5.0% (w/w) graft copolymer;

about 1.5% (w/w) acrylic (acrylic type) copolymer having a backbone containing a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer; And

about 0.5% (w/w) of a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer with an average molecular weight of 4950 and a hydrophilic moiety content of 30% by weight.

[13] Clothianidin may be present in the compositions of the present invention at a concentration of from about 1% to about 60% (wt/wt), preferably from about 10% to about 60% (wt/wt), even more preferably from about 40% to about 60% (w/w), and most preferably about 47.8% (w/w).

[14] The graft copolymer may be present in the compositions of the present invention at a concentration of from about 1% to about 20% (w/w), preferably from about 1% to about 10% (w/w), even more preferably from about 3% to about 7% (w/w), and most preferably about 5.0% (w/w). In a preferred embodiment, the graft copolymer is Tersperse® 2500, Atlox® 4913 or Stepflow® 4000.

[15] An acrylic (acrylic-type) copolymer having a backbone containing a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer may be present in the compositions of the present invention at a concentration of from about 0.1% to about 20% (wt/wt). .), preferably from about 0.1% to about 10% (wt/wt), even more preferably from about 0.5% to about 2.5% (wt/wt), and most preferably about 1. 5% (w/w). In a preferred embodiment, the acrylic (acrylic type) copolymer having a backbone comprising a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer is Envi-pol® 871.

[16] A poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer having an average molecular weight of from about 4950 to about 6500 and a hydrophilic portion content of from about 30% to about 50% by weight can be present in the compositions of the present invention in concentrations from about 0.1% to about 20% (w/w), preferably from about 0.1% to about 10% (w/w), even more preferably from about 0.1% to about 1 % (w/w) and most preferably about 0.5% (w/w). In a preferred embodiment, the ethylenically unsaturated, non-carboxylated monomer and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer with an average molecular weight of 4950 and a hydrophilic moiety content of 30% by weight is Pluronic® P103.

[17] The compositions of the present invention may further contain one or more excipients selected from the group consisting of a friction reducing agent, a liquid wetting agent, an antifoaming agent, a polymer emulsion, a preservative and a thickening agent.

[18] Friction reducing agent suitable for use in the present invention includes, but is not limited to, 25% carnauba wax in water emulsion and micronized polyethylene glycol wax having NPIRI grindometer values of 1.0 to 1. 5. MPP-611XF is one source of micronized polyethylene glycol wax that has NPIRI grindometer values of 1.0 to 1.5 and is available from Micro Powders, Inc.

[19] Friction reducing agents may be present in the compositions of the present invention at a concentration of from about 1% to about 10% (w/w), preferably from about 1% to about 5% (w/w), more preferably from about 2% to about 4% (wt./mass.) and even more preferably about 3% (wt./mass.).

[20] Liquid wetting agents suitable for use in the present invention include, but are not limited to, glycerin, polypropylene glycols and diethylene or polyethylene glycols, ethylhexanediol, hexylene glycol, butylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene-5-laureth-5, polyglycerol cocoate, sorbitol, fructose, glycine, inositol, panthenol and mixtures thereof. In a preferred embodiment, the liquid wetting agent is glycerol.

[21] Liquid wetting agents may be present in the compositions of the present invention at a concentration of from about 1% to about 20% (w/w), preferably from about 1% to about 10% (w/w), more preferably from about 5% to about 7% (w/w), and even more preferably about 6% (w/w).

[22] Antifoam agents suitable for use in the present invention include, but are not limited to, silicone antifoam agents, including silicone emulsions, vegetable oils, acetylene glycols and high molecular weight propylene oxide adducts and lower block copolymers of polyoxyethylene and polyoxypropylene (where the number of octyl-, nonyl and phenyl polyoxyethylene/ethylene oxide is >5) and long chain alcohols, 2,4,7,9-tetramethyl-5-decine-4,7-diol (Surfynol® 104PG-50 (CAS No. 126-86-3) is one source of 2,4,7,9-tetramethyl-5-decine-4,7-diol and is a registered trademark and available from Air Products and Chemicals Inc.) and mixtures thereof. In a preferred embodiment, the antifoam agent is a silicone emulsion.

[23] Antifoam agents may be present in the compositions of the present invention at a concentration of from about 0.01% to about 1% (wt/wt), preferably from about 0.05% to about 0.5% (wt/wt). .), more preferably from about 0.2% to about 0.4% (w/w), and even more preferably about 0.3% (w/w).

[24] Polymer emulsion suitable for use in the present invention includes, but is not limited to, acrylic copolymer in aqueous solution and vinyl acetate-ethylene copolymer in water. AG Coat US emulsion and STFS emulsion are each a source of acrylic copolymer in an aqueous emulsion. AG Coat US emulsion and STFS emulsion are available from Lamberti SPA. Eco VAE 401 is one source of vinyl acetate-ethylene copolymer in water and is available from Celelanese.

[25] Polymer emulsions may be present in the compositions of the present invention at a concentration of from about 1% to about 10% (w/w), preferably from about 1% to about 5% (w/w), more preferably from about 2% to about 4% (w/w), and even more preferably about 3% (w/w).

[26] Thickeners suitable for use in the present invention include, but are not limited to, hydroxyethylcellulose, magnesium aluminum silicate, attapulgite, hydrophilic colloidal silica, alumina, xanthan gum, and mixtures thereof. In a preferred embodiment, the thickener is a mixture of magnesium aluminum silicate and xanthan gum.

[27] Thickeners may be present in the compositions of the present invention at a concentration of from about 0.01% to about 5% (w/w), preferably from about 0.01% to about 1% (w/w), more preferably, from about 0.05% to about 0.5% (w/w), and even more preferably, about 0.1% (w/w).

[28] Preservatives suitable for use in the present invention include, but are not limited to, a solution of 1.15% 5-chloro-2-methyl-4-isothiazolin-3-one and 0.35% 2-methyl-4- isothiazolin-3-one in water, such as Kathon ^® CG/ICP (available from Rohm and Haas Company) and Legend MK ^® (available from Rohm and Haas Company), 19.3% 1,2-benzisothiazolin-3-one and mixtures of them. In a preferred embodiment, the preservative is 19.3% 1,2-benzisothiazolin-3-one.

[29] The preservative is present in the compositions of the present invention at a concentration of from about 0.01% to about 5% (w/w), preferably from about 0.1% to about 5% (w/w), more preferably from about 0.2% to about 0.4% (w/w), and even more preferably about 0.25% (w/w).

[30] Water may be present in the compositions of the present invention at a concentration of from about 1% to about 99% (w/w), preferably from about 10% to about 89% (w/w), more preferably from about 20% to about 40% (w/w) and even more preferably from about 30% to about 35% (w/w) and most preferably about 32.6% (w/w).

[31] In another embodiment, the present invention relates to methods of pest control comprising applying compositions of the invention to an area to be protected from pests.

[32] Pests against which the compositions of the present invention may provide protection include, but are not limited to, aphids and wireworms.

[33] As used herein, "aphid" refers to pests belonging to the superfamily Aphidoidea of the order Hemiptera.

[34] As used herein, "wireworm" refers to pests belonging to the family Elateridae of the order Coleoptera.

[35] As used herein, “pest control” refers to reducing the negative effects of pests on plants or animals to a level desirable to the producer or animal.

[36] As used herein, “site to be protected from pests” refers to any site where a pest is present at any stage of development. One of the preferred media for treatment with the methods of the present invention includes plants, plant propagation material and the pest host and surrounding soil. The pest's habitat may also include harvested plants, gardens, fields, greenhouses or other structures, and various interior surfaces and structures such as furniture, including beds, and furnishings, including books, clothing, etc.

[37] As used herein, the term “plant propagation material” refers to seeds and seedlings of all types (fruits, tubers and grains), clonal and micropropagated plants, etc.

[38] In the application, the singular forms (corresponding to the English articles “a”, “an” and “the”) include the plural unless the context clearly requires otherwise.

[39] As used herein, all numerical values relating to quantities, percentages by weight, etc. are defined as "approximate" or "approximate" a specific value plus or minus 10%. For example, the phrase “at least 5.0% by weight” should be understood as “at least 4.5% to 5.5% by weight.” Thus, amounts within 10% of the claimed values are included within the scope of the claims.

[40] These exemplary embodiments are not limiting and are described solely to illustrate certain aspects of the invention.

[41] In addition, the following examples are provided for illustration only and not limitation.

EXAMPLES

Table 1

% (mass/mass) No. 1 No. 2 Clothianidin 47.8 47.8 graft copolymer 5.0 5.0 An acrylic (acrylic-type) copolymer having a backbone containing a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer 1.5 1.0 Block copolymer poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) with an average molecular weight of 4950 and a hydrophilic part content of 30% by weight 0.5 - Carnauba wax (25% emulsion in water) 3.0 3.0 Silicone emulsion 0.3 0.3 Acrylic copolymer in water emulsion 3.0 3.0 19.3% 1,2-benzisothiazolin-3-one 0.25 0.075 Xanthan gum 0.1 0.075 Glycerol 6.0 6.0 Water+impurities from clothianidin TG 32.55 33.75

[42] The graft copolymer source used was Tersperse® 2500 (Tersperse is a registered trademark and available from Huntsman Petrochemical Corporation).

[43] Envi-pol® 871 (Envi-pol is a registered trademark and available from Lamberti SPA) was used as a source of acrylic (acrylic type) copolymer having a backbone containing a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer.

[44] Pluronic® P103 (Pluronic is a registered trademark and available from BASF Corporation) was used as a source of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer. Pluronic® P103 has an average molecular weight of 4950 and a hydrophilic content of 30% by weight.

[45] The source of carnauba wax (25% emulsion in water) used was Michem® Lube 156PFP (CAS No. Closed), which is a registered trademark and available from Michelman Inc.

[46] Xiameter® AFE-0010 (Xiameter is a registered trademark and available from Dow Corning Corporation) was used as the silicone emulsion source.

[47] AG Coat US emulsion, available from Lamberti SPA, was used as a source of acrylic copolymer in aqueous emulsion.

[48] Proxel® GXL was used as a source of 19.3% 1,2-benzisothiazolin-3-one (Proxel is a registered trademark of Arch UK Biocides and is available from Lonza).

[49] Kelzan® CC (Kelzan is a registered trademark and available from CP Kelco) was used as a source of xanthan gum.

Example 1 - Preparation of a composition according to the invention

Way

Obtaining a liquid carrier

[50] Glycerol was added to water with stirring to obtain a carrier. The graft copolymer and an acrylic (acrylic type) copolymer having a backbone containing a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer were then added to the carrier. In a separate container, a 20% EO-PO block copolymer solution was prepared by dissolving a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer with an average molecular weight of 4950 and a hydrophilic portion content of 30% by weight in water with or without heating using conventional low shear mixer. Then a 20% solution of EO-PO block copolymer was added to the carrier with stirring. Finally, a 25% emulsion of carnauba wax in water and a silicone emulsion were added to the carrier with stirring.

Getting the mixture for grinding

[51] Technical clothianidin (purity 99.6%, obtained from Jiangsu Flag Chemical Industry Co., Ltd.) was added to the carrier with stirring for 20 minutes until all clothianidin particles were wetted to obtain a mixture. A bead mill (Dispermat AE-C, equipped with a TML-1 bead grinding system) was then used to grind the mixture using 1.2-1.7 mm zirconium oxide beads to a median particle size ranging from 1.8 to 2.8 microns .

Obtaining the final composition

[52] In a separate container, 1.5% xanthan gum and 2.5% 1,2-benzisothiazolin-3-one were first dissolved in water to form a solution. The solution, the acrylic copolymer in aqueous emulsion and the remaining water were added to the grinding mixture with stirring over a period of 45 minutes to 1 hour.

Example 2 - Surfactant Screening

table 2

% (mass/mass) A Clothianidin 47.8 Surface-active substance 0.5-2.0 graft copolymer 1.5 Polyvinyl alcohol, partially hydrolyzed (24% solution in water) 5.67 2,4,7,9-tetramethyl-5-decine-4,7-diol (50% solution in propylene glycol) 0.063 Carnauba wax (25% emulsion in water) 3.0 Silicone emulsion 0.1 Xanthan gum 0.05 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, solution in water 0.05 Glycerol 5.0 Water Q.S.

[53] Selvol® 24-203 (CAS No. 25213-24-5), which is a registered trademark and available from Sekisui Specialty Chemicals America LLC, was used as a source of partially hydrolyzed polyvinyl alcohol (24% solution in water).

[54] The source of 2,4,7,9-tetramethyl-5-decine-4,7-diol (50% solution in propylene glycol) was Surfynol® 104PG-50 (CAS No. 126-86-3), which is registered trademark and available from Air Products and Chemicals Inc.

[55] Kathon® CG/ICP (CAS No. 26172-55-4) was used as a source of a solution of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one in water and 2682-20-4). They are registered trademarks and are available from Rohm and Haas Company.

Way

[56] Formulation A shown in Table 2 above was prepared without additional surfactant or using each of the 13 surfactants listed in Table 3 below. The 14 formulations were maintained at 54° C. for 2 weeks. After storage under accelerated aging conditions, drainage time, viscosity, and ease of sprayability were measured for 14 formulations. The results of this experiment are shown below in Table 3.

[57] The drip time is the time it takes for the composition to drain from the bottom of the container when 62.5 ml of the composition is placed in a 125 ml plastic jar and tipped on its side. A long drainage time from the bottom indicates poor fluid retention.

[58] The ease of atomization was determined based on the following test procedure and calculations. The 100 mesh (150 micrometer) sieve was weighed and the weight reported as tare weight (“W0”). Then a sieve was placed on a wide-necked jar.

[59] 50-60 grams of the composition (“W”) were weighed and poured through a sieve, after which the sieve was washed. Rinse with tap water at a flow rate of approximately 1.5 liters per minute for one minute. The residue sieve was then placed in an oven and dried to obtain a dry residue sieve (“W1”). The ease of atomization as a percentage was then calculated using the following equation: (W1-W0) / W * 100.

Table 3

Surface-active substance Time of drainage from the bottom (s) Viscosity Absent 120 135 Pluronic® P103 50 227 Pluronic® P104 50 228 Pluronic® P105 60 243 Tersperse® 4894 105 225 Tersperse® 2500 600 181 Reax® 907 140 173 Reax® 85A 300 220 Easysperse ^TM P20 60 419 Agrilan® 755 75 - Envi-pol® 871 0 226 Sorbitol TD 60 300 Glycerol 120 300 Selvol® 24-203 180 246

[60] Pluronic® P103 is a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer with an average molecular weight of 4950 and a hydrophilic portion of 30% by weight.

[61] Pluronic® P104 is a block copolymer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (Pluronic is a registered trademark and is available from BASF Corporation). Pluronic® P104 has an average molecular weight of 5900 and a hydrophilic portion of 40% by weight.

[62] Pluronic® P105 is a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer (Pluronic is a registered trademark and is available from BASF Corporation). Pluronic® P105 has an average molecular weight of 6500 and a hydrophilic content of 50% by weight.

[63] Tersperse® 4894 is an alkylphenol ethoxylate-free, nonionic wetting and dispersing agent combination agent (Tersperse is a registered trademark and is available from Huntsman Petrochemical Corporation).

[64] Tersperse® 2500 is a graft copolymer.

[65] Reax® 907 is a reaction product of lignin, alkali, formaldehyde and sodium bisulfite (Reax is a registered trademark and available from Ingevity).

[66] Reax® 85A is a reaction product of lignin, alkali, disodium sulfite and formaldehyde.

[67] Easysperse ^TM P20 is a spray-dried, optimized polyvinylpyrrolidone and methyl vinyl ether/maleic acid half-ester composite dispersant (Easysperse is a registered trademark and available from Ashland).

[68] Agrilan® 755 is a soft anionic polymer based on a PEG-grafted methyl methacrylate backbone (Agrilan is a registered trademark and available from Nouryon).

[69] Envi-pol® 871 is an acrylic (acrylic type) copolymer having a backbone containing a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer.

[70] Selvol® 24-203 is a partially hydrolyzed polyvinyl alcohol (24% solution in water) and is a registered trademark and available from Sekisui Specialty Chemicals America LLC.

results

[71] As can be seen from Table 2 above, the addition of an acrylic (acrylic type) copolymer having a backbone containing a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer did not result in precipitation, as evidenced by a drain time of less than 25 seconds. Other properties of the composition are given below: relative density 1.26, pH approximately 6, viscosity in the range of 200 cP - 300 cP at 50 s ^-1 , ease of atomization using a 100 mesh screen (150 micron mesh size) is 0-0.1% .

Example 3 - Flowability of compositions according to the invention

Way

[72] Formulations #1 and #2 from Table 1 above were compared with the commercially available NipsIt® INSIDE formulation (see Table 5 below for NipsIt® INSIDE formulation ingredients). Specifically, Formulations No. 1 and No. 2 and NipsIt® INSIDE were stored under different conditions as detailed below in Table 3. After storage under accelerated aging conditions, drainage time from the bottom was assessed. The results of this experiment can be found below in Table 4.

Table 4

Storage conditions Time of drainage from the bottom (s) NipsIt® INSIDE Composition No. 1 Composition No. 2 5 freeze/thaw cycles 2-50 0 0 54°C for 2 weeks 75-120 0 9 50°C for 4 weeks 80-120 0 n/a less than -15°C for 8 weeks 0-10 0 0 40°C for 8 weeks 45-120 0 n/a 50°C for 8 weeks 300-1200 10 10 4°C for 16 weeks 10-60 0 n/a 40°C for 16 weeks 105-420 8 0 25°C for 6 months 90-135 0 n/a 25°C for 1 year 150-390 25 n/a

Table 5

% (mass/mass) Clothianidin TG (97.5%) 49.0 Michem® Lube 156P 3.0 Selvol® 24-203 5.67 Glycerol 4.3 Sorbitol, 70% solution 6.14 Tersperse® 2500 1.17 Stepfac® TSP PE-K 0.244 Surfynol® 104PG 0.063 Due-O-Set® E 200 2.8 Kathon® CG/ICP 0.05 Kelzan® CC 0.035 Water 27,528

Result

As can be seen from Table 4 above, Formulations #1 and #2 had improved drain times compared to NipsIt® INSIDE under all storage conditions tested. Thus, the particular combination of excipients in formulations #1 and #2 provides improved stability compared to commercially available NipsIt® INSIDE.

Claims (31)

1. Stable pesticide composition containing: from 10 to 60% w/w clothianidin; from 1 to 10% w/w graft copolymer; And from 0.1 to 10% w/w an acrylic type copolymer having a backbone containing a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer; from 0.1 to 10% w/w a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer with an average molecular weight from 4950 to 6500 and a hydrophilic part content from 30 to 50% by weight; And from 10 to 87.8% w/w water, where "mass/mass" denotes the ratio of mass to the total mass of the composition. 2. Composition according to claim 1, containing: from 40 to 60% w/w clothianidin; from 3 to 7% w/w graft copolymer; from 0.5 to 2.5% w/w an acrylic type copolymer having a backbone containing a carboxylated ethylenically unsaturated monomer and a non-carboxylated ethylenically unsaturated monomer; And from 0.1 to 1% w/w block copolymer poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) with an average molecular weight of 4950 and a hydrophilic part content of 30% by weight. 3. Stable pesticide composition containing: 47.8% w/w clothianidin; 5.0% w/w graft copolymer; 1.5% w/w an acrylic type copolymer having a backbone containing a carboxylated monomer with ethylenic unsaturation; And 0.5% w/w a non-carboxylated monomer with ethylenic unsaturation and a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer with an average molecular weight of 4950 and a hydrophilic part content of 30% by weight, optionally one or more additional excipients; And water to bring the total mass of the composition to 100%, where "mass/mass" denotes the ratio of mass to the total mass of the composition. 4. Composition according to claim 3, containing: 3.0% w/w 25% carnauba wax emulsion in water; 0.3% w/w silicone emulsion; 3.0% w/w acrylic copolymer in aqueous emulsion; 0.25% w/w 19.3% 1,2-benzisothiazolin-3-one; 0.1% w/w xanthan gum; 6.0% w/w glycerin; And 32.55% w/w water, where "mass/mass" denotes the ratio of mass to the total mass of the composition. 5. A method of pest control, including applying the composition according to claim 1 to the area that needs to be protected from pests. 6. The method according to claim 5, characterized in that said pest is an aphid or wireworm.