RU2791387C1 - Device for extracting blood components from centrifuged whole blood - Google Patents

Abstract

FIELD: medicine; medical equipment; industrial transfusiology.

SUBSTANCE: invention is intended to extract the individual components of a layer-by-layer separated liquid. A device for extracting blood components from centrifuged whole blood contains a fixed plate, a movable plate with a double-sided stroke moved by an electric motor, lines for the individual output of each blood component with valves and transparency sensors, a movable plate position sensor, a unit for setting the movable plate position, movable plate position control unit, block for calculating the position of the movable plate. The movable plate speed calculation unit operates on the basis of data received from the movable plate position control unit. Speed control unit, at the output of which a force task is formed taking into account the value of the current speed of movement, is connected with the force control unit and with the force calculation unit according to information from the current sensor. The force control unit set by the speed control unit, is connected to the voltage generation unit configured to generate voltage on the motor winding by limiting the voltage coming from the power supply. The block for setting the pressure of the fluid flow in the lines, and the block for setting the force with which the movable plate presses on the blood bag are made with the possibility of setting the initial parameters by the operator.

EFFECT: increasing the performance of the device and reduction of the risk of operator error.

1 cl, 1 dwg

Description

The invention relates to medicine, in particular to industrial transfusiology, is intended for extracting individual components of a layer-by-layer separated liquid, and, in particular, a device for extracting blood components from centrifuged whole blood and can be used in blood service institutions, at stations and blood transfusion departments, hematological centers, research and educational medical institutions, mobile medical units.

To extract blood components from centrifuged whole blood, in particular the separation of plasma from red blood cells in polymer containers, mechanical and automatic devices called extractors have been developed. Mechanical extractors are cheap and simple in design and, as a rule, include a body (base) and a mechanical press (movable plate) of constant pressure acting on a container with donor blood components obtained as a result of its centrifugation. In this case, one of the blood components (plasma) moves through the main tube into a receiving container.

The disadvantage of mechanical devices for extracting blood components from centrifuged whole blood is their low efficiency, since when using them, the main tube is pinched manually, and the movement of plasma into the receiving container is controlled visually, which requires the participation of attendants during the entire process of separating blood components, which leads to frequent errors.

A device is known for extracting components from a liquid, in particular from whole blood, the components being present in at least two spatially separated areas, which consists of a flexible bag having at least one output device, this bag being pressed between a fixed plate and a rotary contact plate located at an angle to the latter, and the turning point of the contact plate lying under the bag on the line of intersection of both surfaces of the plate, namely at a distance of more than 30% of the length of the contact plate, and a drive device with an electric or hydraulic drive, rigidly connected to the contact plate by means of a lever (Patent DE 3815643 C2. Published on November 30, 1989).

A device for extracting blood components is known - an automatic plasma extractor "HEMOPRESS", which has a mechanical press (movable plate) and an optical sensor (transparency sensor) to control the process, as well as polymer containers with harvested and identified donor blood (http://nic-com .ru/products/plazmoekstraktor-avtomaticheskij-gemopress).

A device for extracting blood components from centrifuged whole blood is known, containing a fixed plate, a movable plate with a two-way stroke, moved by an electric motor, lines for the individual output of each blood component with valves, a control unit, a data processing device, for transmitting process data from the control unit and built-in optical sensors (transparency sensors) (Patent DE000020316115, IPC C12M 1/26, publ. 29.04.2004).

A device is known for extracting blood components from centrifuged whole blood, containing a fixed plate, a movable plate with a two-way stroke, moved by an electric motor, lines for the individual output of each blood component with valves, a control unit, a data processing device for transmitting process data from the control unit and built-in optical sensors (transparency sensors), movable plate position sensor, movable plate position setting unit, movable plate position control unit, movable plate position calculation unit (https://www.medicalexpo.ru/prod/lmb-technologie-gmbh/product -76654-504516.html).

The disadvantages of the known automatic devices are the static setting of the speed of the press (movable plate), as well as the lack of a system that allows minimizing the time of one cycle of moving the movable plate in order to extrude the liquid, provided that the safe level of pressure inside the bags and lines with blood components is not exceeded, which in turn leads to a decrease in the performance of the device for pumping blood components into the appropriate packages.

The objective of the invention is to create an efficient device for extracting blood components from centrifuged whole blood, which allows to ensure high quality of the resulting product, as well as
increase productivity and reduce the risk of operator error.

The technical result is to increase the performance of the device and reduce the risk of operator error.

This is achieved by the fact that in the claimed device for extracting blood components from centrifuged whole blood, containing a fixed plate, a movable plate with a bilateral stroke, moved by an electric motor, lines for the individual output of each blood component with valves and transparency sensors, a movable plate position sensor , movable plate position setting unit, movable plate position control unit, movable plate position calculation unit according to the invention further comprises: a movable plate speed calculation unit based on data received from the movable plate position control unit; speed control unit, at the output of which a force task is generated, taking into account the value of the current displacement speed, associated with the force control unit and with the force calculation unit according to information from the current sensor, while the force control unit specified by the speed control unit is connected to the voltage generation unit , made with the possibility of generating voltage on the motor winding by limiting the voltage coming from the power supply, and the block for setting the pressure of the fluid flow in the lines, and the block for setting the force with which the movable plate presses on the blood bag, are made with the possibility of setting the initial parameters by the operator .

The inventive device for extracting blood components from centrifuged whole blood into separate containers is shown in FIG. 1 and consists of: 1, 2 - fixed plate, 3 - movable plate, 4 - screw gear, 5 - electric motor, 6 - bag with blood components; 7, 8 - lines, 9 - transparency sensor on line 7; 10 - transparency sensor on line 8; 11- valve on line 7; 12 - valve on line 8; 13 - package for collecting components from line 7; 14 - package for collecting components from line 8; 15 - position setting unit (BZP), 16 - position control unit (BKP), 17 - position calculation unit (BRP), 18 - speed calculation unit (BRS), 19 - speed control unit (BKS), 20 - pressure setting unit (BZN), 21 - force setting unit (BZU), 22 - force control unit (BKU), 23 - force calculation unit (BRU), 24 - voltage generation unit (BFN), 25 - current sensor (DT), 26 - movable plate position sensor (DPP), 27 - power supply unit (BP).

The device works as follows.

Pre-centrifuged blood (separated into the main components - plasma, platelets, leukocytes, erythrocytes) is in a plastic bag 6, to which plastic tubular lines 7 and 8 are attached for pumping liquid. The movable plate 3 is located between the fixed plates 1 and 2. The package 6 is placed between the plates 1 and 3. When the package 6 is squeezed by the plate 3, which is moved by the electric motor 5 through the screw gear 4, which is started, the liquid (blood components) is squeezed out of the package 6 and overflow along lines 7 and 8 into the corresponding packages 13 and 14. At the same time, the speed of squeezing the package determines the pumping capacity, pressure in the lines, and pressure at the outlet. For each line 7 and 8, a corresponding valve 11 and 12 is installed, blocking, if necessary, the flow of liquid in the line. The presence in the line of the blood component required for each of the packages 13 and 14 is determined using the corresponding sensors 9 and 10, based on the information from which a decision is made to block the flow of blood components going to the packages 13 or 14 through valves 11 or 12. The blocking of the flow is carried out when a component appears in the line passing through the sensor that does not correspond to this package.

The operator sets the initial parameters for the allowable force (pressure in the bag with blood components) through block 21 and the required pressure through block 20. After that, through block 15, he gives a command to move the movable plate to the position of squeezing the bag with blood components 6. The command to move gets from block 15 to block 16. Block 16, based on data from position sensor 26 and block 17, generates a task for the speed of movement to block 19. In this case, the value of this task is limited at the level of the value set through block 20 (pressure limitation). At the output of block 19, the force task is formed taking into account the value of the current displacement speed received from block 18, if the speed is less than the specified one, block 19 increases the force task, otherwise it reduces the force task. The generated task for the force from block 19 is fed to block 22, which is engaged in the formation of the force of the movable plate. In this case, the value of the input value of the force from block 19 is limited by the value of the force specified by the operator through block 21. The output value in block 22 is formed based on the value of the current developed force, which is calculated in block 23 based on information from the current sensor 25. If the current force less than specified (taking into account the restrictions from block 21), then the output value of block 22 increases, otherwise decreases. The generated value of block 22 enters block 24, which directly generates voltage on the motor windings by limiting the voltage coming from power supply 27.

Example

The package (container) with settled blood cells is carefully removed from the centrifuge and placed in the extractor. The valve of the fractionated blood bag opens.

Set the "Plasma acquisition" mode. We set the "pressure limit" as 0.1 m., "pressure limit" as 0.3 atm. A command is given to move the plate, with a limitation on the force and speed of the plate movement. As the plate moves, the plasma is pumped down the line into the empty plasma collection bag. When a signal appears on the transparency sensor about a change in transparency, which indicates the complete consumption of plasma and the appearance of erythrocytes in the line, the valve is activated, the movable plate moves away from the bag with the original blood. After that, the operator seals the lines of the package with plasma, disconnects the line connecting the package with the received plasma and the original blood.

The plastic bag with plasma is sent for storage or for further processing to obtain plasma preparations in accordance with the current regulations.

Claims (5)

A device for extracting blood components from centrifuged whole blood, containing a fixed plate, a movable plate with a two-way stroke, moved by an electric motor, lines for the individual output of each blood component with valves and transparency sensors, a movable plate position sensor, a movable plate position setting unit, movable plate position control unit, movable plate position calculation unit, characterized in that it additionally contains: - a block for calculating the speed of the movable plate based on data received from the block for controlling the position of the movable plate, - a speed control unit, at the output of which a force task is generated, taking into account the value of the current movement speed, associated with the force control unit and with the force calculation unit based on information from the current sensor, at the same time, the force control unit specified by the speed control unit is connected to the voltage generation unit, configured to generate voltage on the motor winding by limiting the voltage coming from the power supply unit, and the block for setting the pressure of the fluid flow in the lines, and the block for setting the force with which the movable plate presses on the blood bag, are made with the possibility of setting the initial parameters by the operator.

Images