RU2781440C1 - Automatic analyzer - Google Patents

Abstract

FIELD: automatic analyzers.

SUBSTANCE: invention relates to an automatic analyzer and concerns the analysis of multiple groups of analysis elements (biochemistry, immunity) using a single block. The automatic analyzer comprises a first dispenser unit for issuing a sample of the first group of analysis elements, a second dispenser unit for issuing a sample of the second group, an input unit for receiving input of analytical information, a classification unit for classifying analysis information into the first group and the second group of analysis elements, and a determination unit for determining output sequence for each sample for the first group and for the second group of elements of analysis. The first group has a high probability of transfer between samples, and the second group has a low probability. The first group of elements of analysis indicates the group associated with biochemistry, and the second group indicates the group associated with immunity.

EFFECT: invention provide the reduction in the influence of transfer between samples, that is, a decrease in the analysis error with a plurality of analysis elements.

16 cl, 22 dwg

Description

Technical field

The present invention relates to an automatic analyzer.

Prerequisites for the creation of the invention

In the automatic analyzer, in order to reduce the effect of sample transfer (hereinafter referred to as transfer) in the analysis between samples, there is a technology that classifies biochemistry and immunity within the same sample and allocates biochemical analysis elements first (see JP-A-2010-025587 (PTL 1)).

Analogues

Patent Literature

PTL: JP-A-2010-025587

Brief description of the invention

Technical task

According to PTL 1 described above, since only the determination of the dispensing sequence for each sample is considered, there is a problem that the reduction of carryover between samples is insufficient.

Therefore, it is an object of the present invention to provide an automatic analyzer capable of further reducing carryover between samples.

Solution of the task

According to an aspect of the present invention, an automatic analyzer is provided, including a first dispensing unit for dispensing a sample belonging to a first analysis element group having a high carryover probability, a second dispensing unit for dispensing a sample belonging to a second analysis element group having a low carryover probability. , an input unit for receiving input of analysis information related to a plurality of analysis items for a sample, a classification unit for classifying the analysis information into a first analysis item group and a second analysis item group, and a determination unit for determining a dosing sequence for each sample for the first analysis item group, and determining the issuance sequence for each analysis element for the second group of analysis elements.

Useful effects of the invention

In accordance with the present invention, it is possible to provide an automated analyzer capable of reducing carryover between samples.

Brief description of the drawings

In FIG. 1 is a diagram showing the entire configuration of the automatic analyzer.

Fig. 2 is a diagram showing the relationship between a device cycle and a dosing cycle.

In FIG. 3 is a flowchart for determining the issuance sequence.

Fig. 4A is a diagram showing Table 1.

Fig. 4B is a diagram showing Table 2.

Fig. 5A is a diagram showing the case where dosing is performed according to the analysis request.

Fig. 5B is a diagram showing the case where all samples are distributed in descending order of reaction time.

Fig. 6A is a timing diagram to illustrate the problems of the embodiment of FIG. 5A.

Fig. 6B is a timing diagram to illustrate the problems of the embodiment of FIG. 5V.

Fig. 7A is a diagram showing the output sequence corresponding to S304 of Example 1.

Fig. 7B is a timing chart corresponding to S304 of Example 1.

Fig. 8A is a diagram showing the output sequence corresponding to S305 of Example 1.

Fig. 8B is a timing chart corresponding to S305 of Example 1.

Fig. 9 is a block diagram of Example 2.

Fig. 10A is a diagram showing Table 5.

Fig. 10B is a diagram showing the analysis sequence of Example 2.

In FIG. 11 shows the timing diagram of example 2.

Fig. 12 is a flowchart for determining the dosing sequence in Example 3.

Fig. 13A is a diagram showing Table 8.

In FIG. 13B is a view shown in Table 9.

Fig. 14A is a diagram showing an example in which the analysis sequence is rearranged for only the second group of analysis elements.

Fig. 14B is a diagram showing an example in which the dispensing sequence is rearranged based on the analysis time of one sample for the first analysis element group.

Description of implementation options

In FIG. 1 is a diagram showing the entire configuration of the automatic analyzer. The automatic analyzer 100 is a complex automatic analyzer that analyzes a plurality of groups of analysis elements (biochemistry, immunity) with a single unit. In order to reduce the device size, a predefined mechanism is shared among multiple analysis element groups.

The automatic analyzer 100 includes an incubator 1, a reaction vessel 2, a common disk 3 for storing a reagent and a sample, a reagent vessel 4, a sample vessel 5, a first dispenser 8 for dosing a sample and a reagent for biochemical analysis using a first nozzle, a second dispensing unit 9 for issuing a sample and a reagent for immunity using a second nozzle, the first pump 10, which provides rotation and vertical movement of the first dosing device 8, the second pump 11, which provides rotation and vertical movement of the second dosing device 9, the first washing bath 12 for cleaning the first nozzle, the second wash bath 13 for cleaning the second nozzle, reagent mixing unit 14, spectrophotometer 15, detection unit 16, e.g. for tip 17, tray 20 for reaction vessel 2, disposal unit 21 for storing used tip 17 and reaction vessel 2, tip 17 installation position 22, tip 17 disposal position 23, used liquid storage tank 24, water supply tank 25 for biochemical measurements, water supply tank 26 for immunoassay, container 27 for storing cleaning liquid and a control device 30 for performing various control functions of the automatic analyzer 100.

The incubator 1 includes a reaction vessel 2 for storing the mixed solution of sample and reagent around its circumference, and maintains the reaction vessel 2 at a constant temperature to promote the reaction of the mixed solution. The incubator 1 is controlled by a drive mechanism such as a motor that is rotated and driven a distance corresponding to a predetermined number of reaction vessels 2 in one cycle.

The reaction vessel 2 is a vessel having common technical characteristics for all reactions and is disposable. With respect to the installation positions of the reaction vessels 2, the reaction vessels 2 are arranged alternately around the circumference so that, for example, the biochemical analysis vessels are in odd positions and the immunoassay vessels are in even positions.

On the common disk 3 around the circumference there are many containers 4 for reagents and containers 5 for samples. An example is shown here in which the reagent vessels 4 are located on the inner circumference of the sample vessels 5, but the sample vessels 5 can be located on the inner circumference of the reagent vessels 4 and can be located without distinguishing the inner circumference and outer circumference from each other.

The first dosing unit 8 performs dosing of the reagent and dispensing the sample from the reagent tank 4 and the sample tank 5 to the reaction tank 2 by drawing an arc around the rotation axis. According to the current of the first dosing device 8, there are position 7-1 for aspiration of the sample and position 6-1 for aspiration of the reagent on the common disk 3, the first dispensing position and the second dispensing position on the incubator 1 and the first washing bath 12. At the same time, the second dosing unit 9 performs dosing reagent and the issuance of the sample from the tank 4 for reagents and the tank 5 for samples in the reaction tank 2, describing an arc around the axis of rotation. In the path of the second dosing device 9, there are position 7-2 for aspiration of the sample and position 6-2 for aspiration of the reagent on the common disk 3, the third dosing position and the fourth dosing position on the incubator 1 and the second wash bath 13. In addition, in the case of an immunoassay an accurate measurement is required, and this is essential to prevent carryover between samples. Therefore, the second dispensing unit 9 performs dispensing using the tip 17. Accordingly, the installation position 22 and the removal position 23 are in the path of the second dispensing device 9. At the same time, in the case of biochemical analysis, since accuracy is not required as much as in immunoassay, the first dosing device 8 performs dosing while cleaning the first nozzle in the first wash bath 12 each time dosing is performed without using the tip 17.

The first metering device 8 and the second metering device 9 are arranged in such a way that the paths of the first nozzle and the second nozzle and the corresponding mechanisms of these devices do not physically interfere with each other. The first dispensing unit 8 and the second dispensing unit 9 aspirate the sample and the reagent, and then stir and mix the sample and the reagent in the reaction vessel 2 by an aspiration/discharge operation. For a sample used for both biochemical and immunological analysis, the sample is accessed by both the first dispenser 8 and the second dispenser 9.

Spectrophotometer 15, located around the incubator 1, is used for biochemical analysis. The spectrophotometer 15 is equipped with a light source or detector (not shown) and measures the absorbance of the reaction solution by spectroscopic detection of transmitted light obtained by irradiating the reaction solution in the reaction vessel 2 with light.

The detection unit 16 is used for immunoassay. The reaction solution whose reaction is stimulated by the incubator 1 is sent to the detection unit 16 and analyzed by electrochemical luminescence or chemiluminescence. Reagents or marking agents suitable for each case are selected, as well as the structure and physical properties of the detection area, and a detector (eg, a photomultiplier tube) measures the amount of luminescence resulting from the luminescence reaction of the marking agent.

The transport unit 18 transports the reaction vessel 2 whose absorbance measurement is completed in the incubator 1 to the disposal unit 21 and disposes of the reaction vessel 2. Next, the transport unit 18 transports the reaction vessel 2 containing the reaction solution whose reaction was stimulated by the incubator 1 to the detection unit 16 . In addition, the transport unit 18 transports the reaction vessel 2 analyzed by the detection unit 16 to the disposal unit 21 and disposes of the reaction vessel 2.

The control device 30 is connected to each mechanism of the automatic analyzer 100 (connection not shown), and includes a control unit 31, a storage unit 32, an input unit 33, and a display unit 34. The control unit 31 controls the first dosing unit 8 and the second dosing unit 9 to perform parallel dosing, as well as the rotation drive of the incubator 1, rotation of the common disc 3, nozzle drive, sample aspiration and discharge, and the like. The storage unit 32 stores programs or various data of the classification unit 35 or the determination unit 36, which will be described later. The input block 33 receives a command from the user. The display unit (display) 34 displays the analysis result. An input block 33 and a display block 34 may be integrated as a user interface. The control unit 31 reads and executes the program of the classification unit 35 or the determination unit 36 from the storage unit 32 to implement the embodiment to be described later. In addition, the classification unit 35 or the determination unit 36 may be implemented in hardware.

In FIG. 2 is a diagram showing the relationship between a device cycle and a dosing cycle. In this embodiment, the device cycle is 10 seconds, and one biochemical cycle is two device cycles. In the first half cycle of two cycles, the first reagent and sample are dosed and mixed in reaction vessel 2 (first biochemical dosing and mixing), and in the second half cycle of two cycles, the second reagent is dosed and mixed in reaction vessel 2 (second biochemical dosing and mixing). Next, the reaction vessel 2 is installed and removed from the incubator 1 in the second half.

One protection cycle is six device cycles. The reaction vessel 2 for immunity is installed in the incubator 1 in the first cycle of the device cycle and removed in the third cycle. The first dosing is performed in the fourth cycle of the device cycle, and the second dosing is performed in the sixth cycle. The time for the first pipetting is the time from the first to the fourth cycle of the device cycle, but the time from the first to the third cycle is used to set the tip and aspirate reagents and samples. At this time, the first biochemistry dispensing unit 8 also aspirates reagents and samples, the biochemistry and immunity reagents are mounted on the common disc 3, and thus the time at which the first dispensing unit 8 and the second dispensing unit 9 perform the aspiration operation are controlled by such so as not to overlap.

The mark in Fig. 2 indicates the sample issuance time. When the chemistry analysis elements and the immunoassay elements coexist for the same sample, both the first chemistry analysis nozzle and the second immunity nozzle access the same sample vessel. However, since the labels do not overlap between biochemistry and immunity assays, the first nozzle and the second nozzle do not interfere with each other.

Here, in JP-A-2010-025587 (PTL 1), assay elements are classified into biological assay elements and immunoassay elements in the same sample, and allocation is performed first for biochemical analysis and then for immunity assay. Since the nozzle is cleaned every time one assay element is dispensed, when there are many chemistry elements, the nozzles are cleaned in the same amount as the plurality of chemistry elements, and then the process proceeds to protection dispense. In other words, the influence of the previous sample is practically absent, and there is an effect in which carryover, leading to an analysis error, can be reduced. In addition, for a certain sample, when there are a plurality of biochemistry assay elements, the above-described effects can be obtained, but when there is only one biological assay element (the number of elements is small) or when there are only immunoassay elements, dosing for determining immunity is performed with the same nozzle immediately after dispensing the previous sample. Therefore, there is also a problem that the probability of occurrence of transfer increases. In addition, in JP-A-2010-025587 (PTL 1), dosing related to biochemistry and immunity is performed using the same sample dosing device. Therefore, it should also be noted that the assumption in PTL 1 is different from the assumption in this automatic analyzer, which uses a biochemistry sampler and an immune sampler separately.

In addition, in WO 2017/138285, in order to reduce the analysis time, the dosing is performed in descending order of the reaction time of the analyzed elements. However, when measuring in descending order of assay response time for all samples, there is a high probability that a certain sample (pre-sample) is dispensed, and then a sample (post-sample) that is different from the pre-sample is often dispensed. As a result, the pre-sample attached to the first nozzle is likely to be mixed with the subsequent sample, increasing the chance of carryover. In particular, in the case of an automatic analyzer that shares reagents and samples on a common disk 3, reagents or samples cannot be added until the analysis operation of all samples is completed, and thus, when analysis completion is delayed, adding reagents or samples for use in the next analysis will be postponed and the effectiveness of the analysis will decrease.

Therefore, in the following, an embodiment relating to an automatic analyzer that can further reduce carryover will be described, in particular, an automatic analyzer that can achieve both a reduction in carryover between samples and a reduction in analysis time by using different sample dispensers for different elements. analysis. In addition, the following will describe that the program is the main control in some cases, but needless to say, this means that the control unit 31 reads the program from the storage unit 32 and executes the program.

Example 1

In FIG. 3 is a flowchart for determining the dosing sequence. The flow diagram shows the flow after the user registers the parameters necessary for analysis in advance in the memory device 32 through the input block 33, installs the sample and reagent, and gives the command to start the analysis (presses the analysis start button).

First, the control unit 31 obtains information (hereinafter referred to as analysis information) necessary for analyzing the target component contained in the sample. More specifically, a table (hereinafter referred to as Table 1) listing the sample types shown in FIG. 4A and the analysis elements for the sample are related to each other, obtained (S301). Table 1 is associated with a table (hereinafter referred to as Table 2) in which each element of the analysis is shown in FIG. 4B is related to the reaction time. The contents of table 1 is entered by the user through the block 33 input. The contents of the table 2 is stored in the storage unit 32 beforehand.

A label (eg barcode, 2D code or RFID) is affixed to the sample container 5 and the analysis elements for the sample are stored on the label. A reader (not shown) reads the analysis elements from the label and transmits the analysis elements to the control device 30. The control unit 31 matches the analysis elements with the parameters registered by the user and generates table 1 based on the matched analysis elements.

Then, the classification unit 35 classifies the analysis information into a first analysis element group and a second analysis element group. In other words, Table 1 is divided into each analysis item group (S302). In the case of biochemical analysis, the nozzle is in direct contact with the reagent or sample, and thus there is a high possibility of transfer. Meanwhile, in the case of immunoassay, since the nozzle has a dosing tip 17 attached thereto, the possibility of transfer is low. Thus, Table 1 is divided into an analysis element group having a high transfer probability as the first analysis element group (biochemistry) and an analysis element group having a low transfer probability as the second analysis element group (immunity). Thus, a table (hereinafter referred to as Table 3) is created only for the first group of analysis elements and a table (hereinafter referred to as Table 4) only for the second group of analysis elements.

Next, the determining unit 36 determines the output sequence for each sample for the first analysis element group, and determines the output sequence for each sample for the analysis element for the second analysis element group. More specifically, the determination unit 36 determines whether or not a priority element (which will be described later) is included in table 4 (S303), and when the priority element is not included, the output sequence is not rearranged for table 3, but the output sequence is rearranged in descending order of response time for table 4 (S304). Meanwhile, when the priority element is turned on, the determining unit 36 places the priority element first in table 4, and places the same pattern as the one having the priority element to be placed last in table 3, and rearranges the output sequence in descending order of reaction time common elements (which will be described later) in Table 4 (S305). When there is no pattern that matches the pattern having the priority element in table 3, the output sequence is not reordered. In addition, in Table 4, when a plurality of priority items are included, the issuance sequence of priority items is rearranged in descending order of reaction time, after the priority items, the issuance sequence of general items is rearranged in descending order of response time.

After S304 or S305, the control unit 31 starts the output associated with the sample that is the target of the analysis request in accordance with the determined output sequence.

Here, the priority element (also referred to as the high priority element) is one of the types of immunity elements, and indicates an analysis element that requires particularly precise analysis among the immunity elements. The common element shows the element of normal immunity (element of the immunoassay requiring normal accuracy). In other words, the priority element has a higher priority than the general element.

For example, when the first nozzle accesses the sample vessel A, there is a possibility that impurities present on the first nozzle are mixed in the sample vessel A. Thereafter, when the second nozzle accesses the sample vessel A, there is a possibility that the second nozzle sucks in impurities. Since the first nozzle is cleared each time dosing is performed, this problem is trivial in the case of a common element, but even a trivial effect must be taken into account in the case of a priority element. Accordingly, the control unit 31 executes the control to issue the priority element first without being affected by the transfer.

In addition, for example, there are a plurality of priority elements, and it is necessary for the second nozzle to first access the sample vessel A and then the sample vessel B. Here, when only the priority element first output control is performed, the sequence can also be received in which the second nozzle accesses the sample vessel A, the first nozzle accesses the sample vessel A, the first nozzle accesses the sample vessel B, the second nozzle accesses the sample vessel B. Then the impurities attached to the first nozzle, that accessed Sample Vessel A are mixed in Sample Vessel B, and then a second nozzle accesses Sample Vessel B, which affects priority elements. Accordingly, in the biochemical analysis, the control unit 31 executes the control to dispense the same sample as the sample having the priority element at last.

Fig. 4 is a diagram representing analytical information, FIG. 4A shows Table 1 and FIG. 4B shows Table 2. Hereinafter, the sample is referred to as S (sample), the biochemical element is referred to as CC (clinical chemistry), and the immunoassay element is referred to as IA (immunoassay). Depending on the number of types, numbers are added next to the letters, such as S1, S2…, CC1, СС2… and IA1, IA2…. Examples of CC include AST, GLU, CREJ, HDL-C and the like, and examples of IA include hCG STAT, CEA, TSH, folate and the like. Shown here is an example of performing a biochemical and immunological analysis on a total of 5 samples.

Fig. 5 is a diagram showing an output sequence for describing a problem of an embodiment, FIG. 5A shows the case where the dosing is in accordance with the analysis request, and FIG. 5B shows the case where all samples are distributed in descending order of reaction time. Next, Fig. 6 is a timing diagram for describing the problem of an embodiment, FIG. 6A corresponds to FIG. 5A and FIG. 6B corresponds to FIG. 5V, respectively. In addition, the start time of the process in the time chart is the time when the discharge to the reaction vessel 2 is first performed. Here, an example is shown in which the discharge for biochemistry and the discharge for immunity are started at the same time, but the start time of these discharges may be shifted. Further, in the case of biochemistry, the analysis is completed only by placing the reaction vessel 2 in the incubator 1, but in the case of immunity, the analysis is performed after the reaction vessel 2 is moved from the incubator 1 to the detection unit 16. In other words, in the case of biochemistry, the analysis is completed at the time indicated in the graph. Meanwhile, in the case of immunity, the time indicated in the timing chart indicates the time during which the reaction is stimulated in the incubator 1, and it is noted that the assay does not end only at this indicated time.

In this example, in FIG. 6B, in which the analysis is performed in descending order of reaction time, requires 4 minutes less analysis time than in FIG. 6A, in which dosing is performed in sequence simply according to the request for analysis. However, looking at the example in Fig. 6B, it can be seen that dispensing for a certain sample and dispensing for another sample are performed alternately. Repeated dosing increases the likelihood of carryover.

Fig. 7 is a diagram showing the process corresponding to S304 of Example 1, in FIG. 7A shows the dispensing sequence, and FIG. 7B shows a timing diagram. Typically, analysis requests are made for each sample, as shown in Table 1, and thus, when the issuance sequence is not rearranged, analysis requests are ordered for each sample. In other words, in the case of biochemistry, by performing dosing according to an analysis request, dosing is performed intensively for the same sample, and the possibility of carryover can be reduced. Meanwhile, in the case of immunity, since the effect of carryover may not be taken into account, the release sequence can be determined for each analysis object regardless of the type of sample. The return mechanism includes a rocker (50) suspended on the first and second springs (52, 54).

Thus, the number of dosing times from one sample to another is 3 in FIG. 5A and 8 in FIG. 5V. In addition, the analysis time is 58 minutes in FIG. 5A and 54 minutes in FIG. 5V. In other words, when dosing is performed according to the requested order, the probability of carryover is small, but the analysis time is long. However, when all samples are distributed in descending order of reaction time, the analysis time can be reduced, but the possibility of carryover is increased.

Meanwhile, in the case of Example 1, the number of dosing times from one sample to another is 3, and the analysis time is 54 minutes. In other words, the number of dosing times from one sample to another can be reduced by 5 compared to the case of simple dosing in descending order of reaction time, and the analysis time can be reduced by 4 minutes compared to the case of simple dosing according to the requested order.

Fig. 8 is a diagram showing the process corresponding to S305 of Example 1, FIG. 8A shows the dispensing sequence, and FIG. 8B shows a timing chart. In FIG. 8A, priority item processing (referred to as high priority (HP)) is added before "S5 IA3 54 minutes" in FIG. 7B. Here, the reaction time of the priority elements is 27 minutes and 18 minutes, the output sequence in descending order of the reaction time is not achieved in general, and thus the analysis time is 56 minutes, which is longer than 54 minutes in FIG. 7B (FIG. 8B). However, since the priority items are distributed in descending order of reaction time, the impact on the overall reaction time may be small. Next, in FIG. 8A, the S1 order is the last one in Table 3. In addition, examples of priority positions include HBsAgII, HBsAg quantII, TG, HIVcombiPT, and the like.

As described above, in Example 1, both carryover reduction and analysis time reduction can be realized, and priority element carryover can be reduced even in the case of immunity.

Example 2

In FIG. 9 shows a block diagram of creating an emergency sample. The flowchart shows the flow after the user registers the emergency sample analysis item in the storage unit 32 via the input unit 33 and instructs the start of the analysis of the emergency sample (presses the start button of the analysis of the emergency sample). In principle, in the case of an automatic analyzer that shares reagents and samples on a common disk 3, reagents or samples cannot be added until the analysis operation of all samples has been completed. However, in an emergency situation, the automatic analyzer will inevitably stop, and the emergency sample may also interrupt an already defined dispensing sequence.

First, the control unit 31 stops dispensing a new sample (S901) and, as shown in FIG. 3 obtains the table (hereinafter referred to as Table 5) associated with the request for analysis of the emergency sample shown in FIG. 10A (S902). The classification unit 35 divides the table 5 into a table (hereinafter referred to as table 6) in which the first analysis element group is the only analysis element group, and a table (hereinafter referred to as table 7) in which the second analysis element group is the only analysis element group (S903) . Then, the determining unit 36 does not rearrange the dosing sequence for table 6, and rearranges the dosing sequence in descending order of the reaction time for table 7 (S904).

Before starting the circuit, the first switch (S1) and the third switch (S3) are turned on and the second switch (S2) is turned off. This determines the presence or absence of reagents and samples at an intermediate dosing step. In the presence of reagents and samples, the process is repeated, and in the absence of reagents and samples, the common disk 3 stops and the process proceeds to setting the sample for urgent analysis (S906). Then, when the installation of the urgent analysis sample on the common disk 3 is completed, the control unit 31 starts dispensing associated with the urgent analysis sample according to the determined dispensing sequence.

Fig. 10 is a diagram showing analysis information when an urgent analysis sample is generated, FIG. 10A shows Table 5 in which urgent analysis sample types and analysis items are related to each other, and FIG. 10B shows the analysis sequence of Example 2. Also in FIG. 11 is a timing diagram corresponding to FIG. 10V.

Shown here is the case where dispensing of 3 samples for urgent analysis is interrupted 2 minutes after dispensing starts. For example, when the button for urgent analysis of samples is pressed during the analysis of No. 5 of Table 3 and No. 2 of Table 4, the interruption of the urgent analysis of samples No. 6-10 and No. 3-5 occurs between No. 5 and No. 6 in Table 3 and between No. 2 and No. 3 in table 4, respectively. As shown in FIG. 11, even when creating a sample for urgent analysis, it is possible to achieve both a reduction in carryover and a reduction in analysis time.

In addition, when the button for urgent sample analysis is pressed during analysis No. 4 of Table 3, priority is given to the urgent sample, and the urgent sample can be analyzed immediately after analysis No. waiting for completion of analysis #5.

In examples 1 and 2, the case was described when the first group of analysis elements refers to biochemistry, and the second group of analysis elements relates to immunity. Here, as shown in FIG. 7B, since there is a large difference between the reaction time of biochemistry and immunity, the reaction time for immunity includes the reaction time for biochemistry, and no adjustment is required for biochemistry. However, the analysis object group is not limited to biochemistry and immunity, and when the difference in reaction time between the first analysis object group with a high transfer probability and the second analysis object group with a low transfer probability is small, even in the first analysis object group, the analysis time can be further reduced by rearranging dosing sequences within the same sample.

In FIG. 12 is a flowchart for determining the dosing sequence in Example 3.

The control unit 31 receives the table (hereinafter referred to as table 8) shown in FIG. 13A (S1201). Table 8 is associated with the table (hereinafter referred to as table 9) shown in FIG. 13V. Next, the classification unit 35 divides the table 8 into each analysis item group (S1202). In other words, a table (hereinafter - Table 10) in which the first analysis element group is the only analysis element group, and a table (hereinafter - Table 11) in which the second analysis element group is the only analysis element group are formed.

Next, the determining unit 36 determines whether the priority element is included in the table 8 (S1203), and if the priority element is not included, the output sequence is rearranged in descending order of the analysis time of one sample (to be described later) for table 10 (S1204), and the output sequence rearranged in descending order of the reaction time for table 11 (S1205). In addition, as a result of permutation, when there are a plurality of samples having the same analysis time length of one sample, the order in which analysis is requested is adopted.

In addition, as a result of permutation, when there are a plurality of samples having the same analysis time length of one sample, the order in which analysis is requested is adopted. For example, sample S1 has 2 analysis positions of the first group of analysis positions, and the analysis time of each analysis position is 7 minutes and 10 minutes, respectively. Further, sample S2 has 3 analytical elements of the first group of analytical elements, and the analysis time of all 3 analytical elements is 10 minutes. In addition, there is a deviation of 20 seconds in the start time of the analysis for each element of the analysis. In this case, in S1, a 10-minute analysis element is started first, and a 7-minute analysis element is started after 20 seconds, but the analysis time of S1 is only 10 minutes in total. In S2, the analysis time of all assay elements is 10 minutes, and thus when dosing starts with a time shift of 20 seconds for each, the analysis time in S2 is 10 minutes and 40 seconds. In other words, if we compare the analysis time of one sample S1 and S2 with each other, then the analysis time of S2 is longer. Accordingly, in the first analysis element group, S2, in which the analysis time of one sample is long, may be issued before S1.1.

Fig. 14 is a timing diagram in Example 3, FIG. 14A shows an example in which the analysis sequence is rearranged for only the second group of analysis elements, and FIG. 14B shows an example in which the output sequence is rearranged for the first group of analysis elements based on one sample analysis time. Here, the analysis element of the first group of analysis elements is designated as X, and the analysis element of the second group of analysis elements is designated as Y. Depending on the number of types, numbers are added next to the letters, for example, X1, X2 ..., and Y1, Y2 ...... Thus, adjusting the sequence of dosing in the first group of elements of analysis, it is possible to reduce the total time of analysis by reducing the transfer.

According to the embodiments described above, in an automatic analyzer comprising a first dispenser for a sample belonging to a first analysis element group having a high carryover probability and a second dispenser for dispensing a sample belonging to a second analysis element group having a low carryover probability, the output sequence is determined for each sample for the first analysis element group, and the output sequence is determined for each analysis element for the second analysis element group. In this way, carryover can be reduced more reliably than in prior art technology in which the dosing sequence is determined only for each sample. In the guidance display mode, the guidance display screen is displayed, in which the functions included in the FB and the explanations of the functions are displayed together with each other.

List of reference positions

100: automatic analyzer

1: incubator

2: reaction vessel

3: common drive

4: reagent vessel

5: sample vessel

6: reagent aspiration position

7: sample aspiration position

8: first dispenser

9: second dispenser

10: first pump

11: second pump

12: first rinsing bath

13: second rinsing bath

14: reagent mixing device

15: spectrophotometer

16: block detection

17: tip

18: transport block

19, 20: tray

21: recycling unit

22: handpiece installation position

23: tip removal position

24: waste tank

25, 26: water supply tank

27: cleaning fluid container

30: control device.

Claims (16)

1. An automatic analyzer comprising a first dispenser unit for issuing a sample belonging to the first group of analysis elements with a high transfer probability, a second dispenser unit for issuing a sample belonging to the second analysis element group having a low transfer probability, an input unit for receiving input of an analytical information related to a plurality of analysis items of the sample, a classification unit for classifying the analysis information into a first analysis item group and a second analysis item group, and a determining unit for determining an output sequence for each sample for the first analysis item group and determining an output sequence for each analysis item for the second groups of elements of analysis. 2. The automatic analyzer according to claim 1, characterized in that, if the second group of analysis elements does not include a priority element having a higher priority than the common element, which requires normal accuracy, the determining unit sets the sequence for issuing analysis elements, included in the first group of analysis elements, in the issuance sequence as described in the analysis information. 3. The automatic analyzer according to claim 2, characterized in that if the second group of analysis elements does not include a priority element, the determining unit rearranges the output sequence of the analysis elements included in the second group of analysis elements in descending order of reaction time. 4. An automatic analyzer according to claim 1, characterized in that, if the second group of analysis elements includes a priority element that has a higher priority than a common element that requires normal accuracy, the determination unit organizes the sequence of issuing a priority element, which should be placed first in the second analysis element group, and organizes the output sequence of the same sample as the sample included in the first analysis element group and including the priority element to be placed last in the first analysis element group. 5. The automatic analyzer according to claim 4, characterized in that, if the second group of analysis elements includes a plurality of priority elements, the determining unit sets the output sequence of the plurality of priority elements in descending order of the reaction time and establishes, after the plurality of priority elements, the output sequence of common elements in descending order of reaction time. 6. The automatic analyzer according to claim 1, characterized in that, if the input unit receives information about the urgent sample, the determination unit determines the output sequence so as to start the analysis of the urgent sample after the analysis of the sample currently being analyzed is completed. . 7. An automatic analyzer according to claim 1, characterized in that the determination unit sets the dosing sequence in the first group of analysis elements in descending order of the analysis time of one sample. 8. The automatic analyzer of claim 1, further comprising a common disk for storing a reagent vessel in which a reagent is stored and a sample vessel in which a common sample is stored. 9. An automatic analyzer comprising an input unit for inputting analytical information related to a plurality of analysis items for a sample, a classification unit for classifying the analysis information into a first analysis item group having a high transfer probability and a second analysis item group having a low transfer probability, and a determining unit for determining a dispensing sequence for each sample for the first assay element group and determining a dispensing sequence for the second assay element group in descending order of reaction time. 10. The automatic parser according to claim 9, characterized in that, if the second group of analysis elements does not include a priority element having a higher priority than the common element, which requires normal accuracy, the determining unit sets the output sequence of the analysis elements included in the first group of analysis elements, into the output sequence as described in the analysis information. 11. The automatic analyzer according to claim 9, characterized in that if the second group of analysis elements includes a priority element having a higher priority than a common element requiring normal accuracy, the determining unit organizes the sequence of issuing a priority element to be located first in the second analysis element group, and sets the output sequence of the same sample as the sample included in the first analysis element group and including the priority element, which should be located last in the first analysis element group. 12. The automatic analyzer according to claim 11, characterized in that, if the second group of analysis elements includes a plurality of priority elements, the determining unit sets the output sequence of the plurality of priority elements in descending order of reaction time and establishes, after the plurality of priority elements, the output sequence of common elements in descending order of reaction time. 13. The automatic analyzer according to claim 9, characterized in that, if the input unit receives information about the urgent sample, the determining unit determines the output sequence so as to start the analysis of the urgent sample after the analysis of the sample currently being analyzed is completed. 14. The automatic analyzer according to claim 9, characterized in that the determining unit sets the dosing sequence in the first group of analysis elements in descending order of the analysis time of one sample. 15. The automated analyzer of claim 9, further comprising a common disk for storing a reagent vessel in which a reagent is stored and a sample vessel in which a common sample is stored. 16. Automatic analyzer according to any one of claims 1 to 15, characterized in that the first group of analysis elements indicates a group of analysis elements associated with biochemistry, and the second group of analysis elements indicates a group of analysis elements associated with immunity.

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