RU2773917C2 - Compositions and methods for causing immune response against clostridium difficile - Google Patents

Abstract

FIELD: biotechnology; medicine.

SUBSTANCE: invention relates to biotechnology and medicine, and it is a method for causing an immune response in a human against Clostridium difficile infection, including the administration to a human of an effective dose of a composition containing C. difficile toxoid with an amino acid sequence SEQ ID NO: 4, where initial methionine is absent, and C. difficile toxoid with an amino acid sequence SEQ ID NO: 6, where initial methionine is absent. In this case, the composition is administered at least three times, while the second administration is performed about 30 days after the first administration, and the third administration is performed about 180 days after the first administration. At the same time, an immune response against C. difficile toxin A and toxin B remains for at least 60 days. In this case, the composition leads to a concentration of a neutralizing antibody specific for toxin B, which is at least 2 times higher in a human after the administration of the third dose, than a concentration of neutralizing antibodies specific to toxin B in a human receiving the third dose about 30 days after the first dose, when measured under identical conditions in cytotoxicity analysis.

EFFECT: obtaining a composition for causing an immune response against Clostridium difficile.

27 cl, 9 dwg, 5 tbl, 11 ex

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority based on U.S. Provisional Application No. 62/577661 filed September 28, 2017, U.S. Provisional Application No. 62/576603 filed October 24, 2017, U.S. Provisional Application No. 62/577661 filed 26 October 2017, and U.S. Provisional Patent Application No. 62/720617, filed August 21, 2018. Each of these patent applications is incorporated herein by reference in its entirety.

FIELD OF TECHNOLOGY TO WHICH THE INVENTION RELATES

The present invention relates to compositions and methods related to Clostridium difficile toxoids and uses thereof.

BACKGROUND OF THE INVENTION

Clostridium difficile(C. difficile) is a Gram-positive anaerobic bacterium associated with gastrointestinal disease in humans. ColonizationC. difficile, usually occurs in the colon when the natural intestinal microbiota is reduced by antibiotic treatment. Infection can lead to antibiotic-associated diarrhea and sometimes pseudomembranous colitis due to the secretion of glycosylation toxins, toxin A and toxin B (308 and 270 kDa, respectively), which are major virulence factors.C. difficile.

In the past decade, the number and severity of outbreaks of C. difficile infection (CDI) in hospitals, nursing homes and other long-term care settings has increased dramatically. Key factors in this escalation include the emergence of hypervirulent pathogenic strains, increased use of antibiotics, improved detection methods, and increased airborne spores in healthcare settings.

The use of metronidazole and vancomycin is the accepted standard of antibiotic treatment for C. difficile disease (CDAD). However, approximately 20% of patients receiving such treatment experience a recurrence of infection after the first episode of CDI, and up to 50% of these patients suffer from subsequent relapses. Treatment of relapses is a very serious problem, and most relapses usually occur within one month of the previous episode.

Humoral immune responses to C. difficile toxins play an important role in preventing more severe outcome or disease recurrence in humans. The results of clinical trials indicate a correlation between high serum concentrations of immunoglobulin G against toxin A (as measured by enzyme immunoassay) and protection from CDI or from relapse after primary CDI. It has been shown that active immunization with inactivated toxins and passive immunization with antibodies against toxins protect animals from lethal outcome upon infection. In addition, hamsters treated with vancomycin alone had higher mortality rates than those treated with vancomycin plus antibodies against the toxin, indicating that vaccination may have advantages over antibiotic treatment.

There is currently no approved, highly effective, non-invasive treatment for complicated C. difficile infection (CDI). Accordingly, there is a need for immunogenic and/or therapeutic compositions, and methods of their use, directed against C. difficile .

SUMMARY OF THE INVENTION

The present invention relates to C. difficile toxoids and methods of using them to solve these and other problems. As used herein, the terms "toxoid", "mutant toxin" and "polypeptide" are synonymous and are used interchangeably unless otherwise indicated. In one aspect, the invention relates to a C. difficile vaccine currently being evaluated for efficacy and safety in subjects at risk for CDI. The choice of the optimal dose and vaccination regimen is based on research findings, taking into account immunogenicity, safety, and the potential for short- and long-term protection.

In one aspect, the invention relates to a method for inducing an immune response in a human against a Clostridium difficile infection. The method includes administering to a human an effective dose of a composition containing the toxoid, ie polypeptide, C. difficile , the composition being administered at least twice. In one embodiment, the second injection is made at least 7 days after the first injection, and the third injection is made about 30 days after the first injection. In one embodiment, the third injection is made approximately 180 days after the first injection. In one embodiment, the composition is administered at least three times. In one embodiment, the second injection is made about 30 days after the first injection, and the third injection is made about 180 days after the first or second injection. In one embodiment, the third injection is made at least 180 days after the first injection.

In one embodiment, the immune response elicited comprises a neutralizing anti-toxin A monoclonal antibody. In one embodiment, the immune response elicited includes a neutralizing anti-toxin B monoclonal antibody. In one embodiment, the immune response elicited includes a neutralizing anti-toxin A monoclonal antibody and a neutralizing anti-toxin monoclonal antibody B, wherein the concentration of the neutralizing monoclonal antibody is at least 10 μg/ml.

In one embodiment, the composition comprises C. difficile toxoid A and/or C. difficile toxoid B, each of which is at least 90% or more pure. In one embodiment, the composition comprises C. difficile toxoid A and/or C. difficile toxoid B in a ratio of about 3:1 to about 1:1. In the method according to claim 1, the composition contains C. difficile toxoid A and/or C. difficile toxoid B in a ratio of 1:1. In one embodiment, the composition contains an adjuvant. In one embodiment, the composition contains an aluminum-based adjuvant.

In one embodiment, the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 60 days. In one embodiment, the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 180 days after the first dose. In one embodiment, the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 180 days after the second dose. In one embodiment, the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 365 days after the first dose. In one embodiment, the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 365 days after the second dose. In one embodiment, the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 540 days after the first dose. In one embodiment, the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 540 days after the second dose.

In one embodiment, the second administration is made at least 7 days after the first administration, and the third administration is made at least 30 days after the first administration. In one embodiment, the third injection is made at least 30 days after the first injection. In one embodiment, the second administration is at least 7 days after the first administration, and the third administration is at least 180 days after the first or second administration. In one embodiment, the third injection is made at least 180 days after the first injection. In one embodiment, the composition comprises C. difficile toxoid A and/or C. difficile toxoid B, each of which is at least 90% or more pure.

In one embodiment, the composition comprises C. difficile toxoid A and/or C. difficile toxoid B in a ratio of about 3:1 to about 1:1. In one embodiment, the composition contains C. difficile toxoid A and/or C. difficile toxoid B in a 1:1 ratio. In one embodiment, the composition contains an adjuvant. In one embodiment, the composition contains an aluminum-based adjuvant. In one embodiment, the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 60 days. In one embodiment, the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 180 days. In one embodiment, the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 365 days.

In one embodiment, C. difficile toxoid A is associated with an aluminum-based adjuvant. In one embodiment, C. difficile toxoid B is associated with an aluminum-based adjuvant. In one embodiment, C. difficile toxoid A and/or C. difficile toxoid B are lyophilized.

In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the first dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 4-fold higher in the human after the first dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 8-fold higher in the human after the first dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 16-fold higher in the human after the first dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the first dose than the toxin A-specific neutralizing antibody concentration in the human before the first dose, when measured under identical conditions. in the cytotoxicity assay.

In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the first dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 4-fold higher in the human after the first dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 8-fold higher in the human after the first dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 16-fold higher in the human after the first dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the first dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay.

In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the second dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 4-fold higher in the human after the second dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 8-fold higher in the human after the second dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 16-fold higher in the human after the second dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the second dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay.

In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the second dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 4-fold higher in the human after the second dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 8-fold higher in the human after the second dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 16-fold higher in the human after the second dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the second dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay.

In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the third dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 4-fold higher in the human after the third dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 8-fold higher in the human after the third dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 16-fold higher in the human after the third dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the third dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay.

In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the third dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 4-fold higher in the human after the third dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 8-fold higher in the human after the third dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 16-fold higher in the human after the third dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the third dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, when measured under identical conditions. in the cytotoxicity assay.

In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in humans after the first dose, as measured at about 7, 30, 60, 90, 120, 365, or 540 days after the first dose. dose than the concentration of toxin A-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in humans after the second dose, as measured at about 7, 30, 60, 90, 120, 365, or 540 days after the second dose. dose than the concentration of toxin A-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay. In one embodiment, the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in humans after the third dose, as measured at about 7, 30, 60, 90, 120, 365, or 540 days after the third dose. dose than the concentration of toxin A-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in humans after the first dose, as measured at about 7, 30, 60, 90, 120, 365, or 540 days after the first dose. dose than the concentration of toxin B-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in humans after the second dose, as measured at about 7, 30, 60, 90, 120, 365, or 540 days after the second dose. dose than the concentration of toxin B-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay. In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in a human after the third dose, as measured on about any day of 7, 30, 60, 90, 120, 365, or 540 days after the third dose than the concentration of toxin B-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay.

In one embodiment, the composition results in a toxin B-specific neutralizing antibody concentration in humans after the third dose that is higher, as measured on about any day of 7, 30, 60, 90, 120, 365, or 540 days after the third dose, than the concentration of toxin B-specific neutralizing antibody in humans prior to the first dose, as measured under identical conditions in the cytotoxicity assay.

In one embodiment, the human is seronegative for toxin B. In one embodiment, the human is seronegative for toxin A. In one embodiment, the human is seronegative for toxin A and toxin B. In one embodiment, the human is seropositive for toxin B In one embodiment, the human is seropositive for toxin A. In one embodiment, the human is seropositive for toxin A and toxin B.

In one embodiment, the toxoid is a polypeptide containing SEQ ID NO: 4, in which the methionine residue is absent. In one embodiment, the toxoid is a polypeptide containing SEQ ID NO: 6, in which the methionine residue is absent. In one embodiment, the toxoid comprises formaldehyde-treated C. difficile toxin A. In one embodiment, the toxoid comprises formaldehyde-treated C. difficile toxin B. In another embodiment, the toxoid is a non-formaldehyde-treated polypeptide.

In one embodiment, the cause of infection is C. difficile ribotype 002. In one embodiment, the cause of infection is C. difficile ribotype 003. In one embodiment, the cause of infection is C. difficile ribotype 004. In one embodiment, the cause of infection is C. difficile ribotype 012. In one embodiment, the cause of infection is C. difficile ribotype 015. In one embodiment, the cause of infection is C. difficile ribotype 017. In one embodiment, the cause of infection is C. difficile ribotype 020. In one embodiment, the cause of infection is C. difficile ribotype 023. In one embodiment, the cause of infection is C. difficile ribotype 027. In one embodiment, the cause of infection is C. difficile ribotype 029. In one embodiment, the cause of infection is C. difficile ribotype 046. In one embodiment, the cause of infection is C. diff icile ribotype 053. In one embodiment, the cause of infection is C. difficile ribotype 059. In one embodiment, the cause of infection is C. difficile ribotype 070. In one embodiment, the cause of infection is C. difficile ribotype 075. In one embodiment, the cause of infection is C. difficile ribotype 078. In one embodiment, the cause of infection is C. difficile ribotype 081. In one embodiment, the cause of infection is C. difficile ribotype 087. In one embodiment, the cause of infection is C. difficile ribotype 106. In one embodiment, the cause of infection is infection is C. difficile ribotype 117. In one embodiment, the cause of infection is C. difficile ribotype 126. In one embodiment, the cause of infection is C. difficile ribotype 131. In one embodiment, the cause of infection is C. difficile ribotype 154. In one embodiment, exercising the cause of infection The infection is C. difficile toxinotype 0. In one embodiment, the cause of the infection is C. difficile toxinotype I. In one embodiment, the cause of the infection is C. difficile toxinotype VIII. In one embodiment, the cause of the infection is C. difficile toxinotype IV. In one embodiment, the cause of the infection is C. difficile toxinotype III. In one embodiment, the cause of the infection is C. difficile toxinotype XIII. In one embodiment, the cause of the infection is C. difficile toxinotype V.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1A-D: FIG. 1A-B - Relative Number of Subjects Scored Above Threshold* - Administration Schedule at Months 0, 1, 6 (Immunogenicity Population). An asterisk (*) corresponds to ≥219 u/mL for toxin A (FIG. 1A) and ≥2586 u/mL for toxin B (FIG. 1B). No sera were collected on days 8 and 15, and at month 4 on a monthly schedule. FIG. 1C and FIG. 1D - Relative Number of Subjects Scored Above Threshold* - Dosage Schedule on Days 1, 8, 30 (Immunogenicity Population). An asterisk (*) corresponds to ≥219 u/mL for toxin A (FIG. 1C) and ≥2586 u/mL for toxin B (FIG. 1D). No sera were collected on days 8 and 15, and at month 4 on a monthly schedule.

FIG. 2A-2D - FIG. 2A-B Geometric Mean Concentrations - Dosage Schedule at Months 0, 1, 6 (Immunogenicity Population). The dotted line (--) corresponds to 219 u/ml for toxin A (FIG. 2A) and 2586 u/ml for toxin B (FIG. 2B). No sera were collected on days 8 and 15, and at month 4 on a monthly schedule. FIG. 2C-D Geometric Mean Concentrations - Dosage Schedule on Days 1, 8, 30 (Immunogenicity Population). The dotted line (--) corresponds to 219 u/ml for toxin A (FIG. 2C) and 2586 u/ml for toxin B (FIG. 2D). No sera were collected on days 8 and 15, and at month 4 on a monthly schedule.

FIG. 3A-B - Overview of adverse events (safety population). The top panel represents the administration mode in months 0, 1, 6 (FIG. 3A). The bottom panel represents the mode of administration on days 1, 8, 30 (FIG. 3B). Note the time periods for recording protocol-specific adverse events: non-serious up to 1 month after dose 3, serious up to 6 months after dose 3 (i.e., time periods for reporting were 5 months longer for the monthly regimen).

FIG. 4A-B - Geometric mean concentrations - Toxin A (population for assessing immunogenicity). The top panel represents the administration mode in months 0, 1, 6 (FIG. 4A). The bottom panel represents the mode of administration on days 1, 8, 30 (FIG. 4B). The dotted line corresponds to 219 u/mL for toxin A; No sera were collected on days 8 and 15, and at month 4 in a monthly regimen; No sera were collected at month 6 and day 187 on a daily regimen.

FIG. 5A-B - Geometric mean concentrations - Toxin B (population for assessing immunogenicity). The top panel represents the administration mode in months 0, 1, 6 (FIG. 5A). The bottom panel represents the administration schedule on days 1, 8, 30. The dotted line corresponds to 2586 u/ml for toxin B (FIG. 5B). No sera were collected on days 8 and 15, and at month 4 in a monthly regimen; No sera were collected at month 6 and day 187 on a daily regimen.

FIG. 6A-B - Geometric Mean Concentrations by Baseline Serostatus - Toxin A (Immunogenicity Population). The top panel represents the introduction mode in months 0, 1, 6 (FIG. 6A). The bottom panel represents the mode of administration on days 1, 8, 30 (FIG. 6B). The dotted line corresponds to 219 u/mL for toxin A; No sera were collected on days 8 and 15, and at month 4 in a monthly regimen; No sera were collected at month 6 and day 187 on a daily regimen.

FIG. 7A-B - Geometric Mean Concentrations by Baseline Serostatus - Toxin B (Immunogenicity Population). The top panel represents the introduction mode in months 0, 1, 6 (FIG. 7A). The bottom panel represents the mode of administration on days 1, 8, 30 (FIG. 7B). The dotted line corresponds to 2586 u/mL for toxin B. No sera were collected on days 8 and 15, and at month 4 on a monthly schedule; No sera were collected at month 6 and day 187 on a daily regimen.

FIG. 8A-B - Geometric mean concentrations versus baseline serostatus - (administration schedule by month) - toxin A and toxin B (immunogenicity population). The top panel represents toxin A (FIG. 8A). The dotted line corresponds to 219 u/mL for toxin A. The bottom panel represents toxin B (FIG. 8B). The dotted line corresponds to 2586 u/mL for toxin B. No sera were collected on days 8 and 15, and at month 4 on a monthly schedule; No sera were collected at month 6 and day 187 on a daily regimen.

FIG. 9A-B - Geometric mean concentrations versus baseline serostatus - (administration schedule by day) - toxin A and toxin B (immunogenicity population). The top panel represents toxin A (FIG. 9A). The dashed line corresponds to 219 u/mL for toxin A. The bottom panel represents toxin B (FIG. 9B). The dotted line corresponds to 2586 u/mL for toxin B. No sera were collected on days 8 and 15, and at month 4 on a monthly schedule; No sera were collected at month 6 and day 187 on a daily regimen.

DESCRIPTION OF SEQUENCES

SEQ ID NO: 1 corresponds to the amino acid sequence of C. difficile 630 wild-type toxin A (TcdA).

SEQ ID NO: 2 corresponds to the amino acid sequence of C. difficile 630 wild-type toxin B (TcdB).

SEQ ID NO: 3 corresponds to the amino acid sequence of the mutant TcdA with the mutation at positions 285 and 287 compared to SEQ ID NO: 1.

SEQ ID NO: 4 corresponds to the amino acid sequence of the mutant TcdA mutated at positions 285, 287 and 700 compared to SEQ ID NO: 1.

SEQ ID NO: 5 corresponds to the amino acid sequence of the mutant TcdB mutated at positions 286 and 288 compared to SEQ ID NO: 2.

SEQ ID NO: 6 corresponds to the amino acid sequence of the mutant TcdB mutated at positions 286, 288 and 698 compared to SEQ ID NO: 2.

SEQ ID NO: 7 corresponds to the amino acid sequence of the mutant TcdA with a mutation at positions 269, 272, 285, 287, 460, 462 and 700 compared to SEQ ID NO: 1.

SEQ ID NO: 8 corresponds to the amino acid sequence of the mutant TcdB with a mutation at positions 270, 273, 286, 288, 461, 463 and 698 compared to SEQ ID NO: 2.

SEQ ID NO: 9 corresponds to the DNA sequence encoding wild-type toxin A (TcdA) C. difficile 630.

SEQ ID NO: 10 corresponds to the DNA sequence encoding wild-type toxin B (TcdB) C. difficile 630.

SEQ ID NO: 11 corresponds to the DNA sequence encoding SEQ ID NO: 3.

SEQ ID NO: 12 corresponds to the DNA sequence encoding SEQ ID NO: 4.

SEQ ID NO: 13 corresponds to the DNA sequence encoding SEQ ID NO: 5.

SEQ ID NO: 14 corresponds to the DNA sequence encoding SEQ ID NO: 6.

SEQ ID NO: 15 corresponds to the wild type C. difficile R20291 TcdA amino acid sequence.

SEQ ID NO: 16 corresponds to the DNA sequence encoding SEQ ID NO: 15.

SEQ ID NO: 17 corresponds to the wild type TcdA amino acid sequence of C. difficile CD196.

SEQ ID NO: 18 corresponds to the DNA sequence encoding SEQ ID NO: 17.

SEQ ID NO: 19 corresponds to the amino acid sequence of C. difficile wild-type TcdA VPI10463.

SEQ ID NO: 20 corresponds to the DNA sequence encoding SEQ ID NO: 19.

SEQ ID NO: 21 corresponds to the wild type TcdB amino acid sequence of C. difficile R20291.

SEQ ID NO: 22 corresponds to the DNA sequence encoding SEQ ID NO: 21.

SEQ ID NO: 23 corresponds to the amino acid sequence of C. difficile CD196 wild-type TcdB.

SEQ ID NO: 24 corresponds to the DNA sequence encoding SEQ ID NO: 23.

SEQ ID NO: 25 corresponds to the amino acid sequence of C. difficile wild-type TcdB VPI10463.

SEQ ID NO: 26 corresponds to the DNA sequence encoding SEQ ID NO: 25.

SEQ ID NO: 27 corresponds to the DNA sequence of the C. difficile wild-type pathogenicity locus VPI10463.

SEQ ID NO: 28 corresponds to the amino acid sequence of residues 101-293 in SEQ ID NO: 1.

SEQ ID NO: 29 corresponds to the amino acid sequence of residues 1-542 in SEQ ID NO: 1.

SEQ ID NO: 30 corresponds to the amino acid sequence of residues 101-293 in SEQ ID NO: 2.

SEQ ID NO: 31 corresponds to the amino acid sequence of residues 1-543 in SEQ ID NO: 2.

SEQ ID NO: 32 corresponds to the amino acid sequence of residues 543-809 in SEQ ID NO: 1.

SEQ ID NO: 33 corresponds to the amino acid sequence of residues 544-767 in SEQ ID NO: 2.

SEQ ID NO: 34 corresponds to the amino acid sequence of the mutant TcdA, while residues 101, 269, 272, 285, 287, 460, 462, 541, 542, 543, 589, 655 and 700 can be any amino acid.

SEQ ID NO: 35 corresponds to the amino acid sequence of the mutant TcdB, wherein residues 102, 270, 273, 286, 288, 384, 461, 463, 520, 543, 544, 587, 600, 653, 698 and 751 can be any amino acid .

SEQ ID NO: 36 corresponds to the amino acid sequence of the light chain variable region of a neutralizing antibody against C. difficile TcdA (A3-25 mAb).

SEQ ID NO: 37 corresponds to the amino acid sequence of the heavy chain variable region of a neutralizing antibody against C. difficile TcdA (A3-25 mAb).

SEQ ID NO: 38 corresponds to the amino acid sequence of the CDR1 variable region of the light chain of a neutralizing antibody against C. difficile TcdA (A3-25 mAb).

SEQ ID NO: 39 corresponds to the amino acid sequence of the light chain variable region CDR2 of a neutralizing antibody against C. difficile TcdA (A3-25 mAb).

SEQ ID NO: 40 corresponds to the amino acid sequence of the light chain variable region CDR3 of a neutralizing antibody against C. difficile TcdA (A3-25 mAb).

SEQ ID NO: 41 corresponds to the amino acid sequence of the CDR1 variable region of the heavy chain of a neutralizing antibody against C. difficile TcdA (A3-25 mAb).

SEQ ID NO: 42 corresponds to the amino acid sequence of the CDR2 variable region of the heavy chain of a neutralizing antibody against C. difficile TcdA (A3-25 mAb).

SEQ ID NO: 43 corresponds to the amino acid sequence of the CDR3 variable region of the heavy chain of a neutralizing antibody against C. difficile TcdA (A3-25 mAb).

SEQ ID NO: 44 corresponds to the DNA sequence encoding SEQ ID NO: 3.

SEQ ID NO: 45 corresponds to the DNA sequence encoding SEQ ID NO: 4.

SEQ ID NO: 46 corresponds to the DNA sequence encoding SEQ ID NO: 5.

SEQ ID NO: 47 corresponds to the DNA sequence encoding SEQ ID NO: 6.

SEQ ID NO: 48 corresponds to the nucleotide sequence of the immunostimulatory oligonucleotide ODN CpG 24555.

SEQ ID NO: 49 corresponds to the amino acid sequence of the heavy chain variable region of a neutralizing antibody against C. difficile TcdB (B8-26 mAb).

SEQ ID NO: 50 corresponds to the amino acid sequence of the signal peptide of the variable region of the heavy chain of the neutralizing antibody against C. difficile TcdB (B8-26 mAb).

SEQ ID NO: 51 corresponds to the amino acid sequence of the CDR1 variable region of the heavy chain of a neutralizing antibody against C. difficile TcdB (B8-26 mAb).

SEQ ID NO: 52 corresponds to the amino acid sequence of the CDR2 variable region of the heavy chain of a neutralizing antibody against C. difficile TcdB (B8-26 mAb).

SEQ ID NO: 53 corresponds to the amino acid sequence of the CDR3 variable region of the heavy chain of a neutralizing antibody against C. difficile TcdB (B8-26 mAb).

SEQ ID NO: 54 corresponds to the amino acid sequence of the heavy chain constant region of a neutralizing antibody against C. difficile TcdB (B8-26 mAb).

SEQ ID NO: 55 corresponds to the amino acid sequence of the light chain variable region of a neutralizing antibody against C. difficile TcdB (B8-26 mAb).

SEQ ID NO: 56 corresponds to the amino acid sequence of the light chain variable region signal peptide of a neutralizing antibody against C. difficile TcdB (B8-26 mAb).

SEQ ID NO: 57 corresponds to the amino acid sequence of the CDR1 variable region of the light chain of a neutralizing antibody against C. difficile TcdB (B8-26 mAb).

SEQ ID NO: 58 corresponds to the amino acid sequence of the light chain variable region CDR2 of a neutralizing antibody against C. difficile TcdB (B8-26 mAb).

SEQ ID NO: 59 corresponds to the amino acid sequence of the light chain variable region CDR3 of a neutralizing antibody against C. difficile TcdB (B8-26 mAb).

SEQ ID NO: 60 corresponds to the amino acid sequence of the heavy chain variable region of a neutralizing antibody against C. difficile TcdB (B59-3 mAb).

SEQ ID NO: 61 corresponds to the amino acid sequence of the signal peptide of the variable region of the heavy chain of the neutralizing antibody against C. difficile TcdB (B59-3 mAb).

SEQ ID NO: 62 corresponds to the amino acid sequence of the CDR1 variable region of the heavy chain of a neutralizing antibody against C. difficile TcdB (B59-3 mAb).

SEQ ID NO: 63 corresponds to the amino acid sequence of the CDR2 variable region of the heavy chain of a neutralizing antibody against C. difficile TcdB (B59-3 mAb).

SEQ ID NO: 64 corresponds to the amino acid sequence of the CDR3 variable region of the heavy chain of a neutralizing antibody against C. difficile TcdB (B59-3 mAb).

SEQ ID NO: 65 corresponds to the amino acid sequence of the heavy chain constant region of a neutralizing antibody against C. difficile TcdB (B59-3 mAb).

SEQ ID NO: 66 corresponds to the amino acid sequence of the light chain variable region of a neutralizing antibody against C. difficile TcdB (B59-3 mAb).

SEQ ID NO: 67 corresponds to the amino acid sequence of the light chain variable region signal peptide of a neutralizing antibody against C. difficile TcdB (B59-3 mAb).

SEQ ID NO: 68 corresponds to the amino acid sequence of the light chain variable region CDR1 of a neutralizing antibody against C. difficile TcdB (B59-3 mAb).

SEQ ID NO: 69 corresponds to the amino acid sequence of the light chain variable region CDR2 of a neutralizing antibody against C. difficile TcdB (B59-3 mAb).

SEQ ID NO: 70 corresponds to the amino acid sequence of the light chain variable region CDR3 of a neutralizing antibody against C. difficile TcdB (B59-3 mAb).

SEQ ID NO: 71 corresponds to the amino acid sequence of the heavy chain variable region of a neutralizing antibody against C. difficile TcdB (B9-30 mAb).

SEQ ID NO: 72 corresponds to the amino acid sequence of the signal peptide of the variable region of the heavy chain of the neutralizing antibody against C. difficile TcdB (B9-30 mAb).

SEQ ID NO: 73 corresponds to the amino acid sequence of the CDR1 variable region of the heavy chain of a neutralizing antibody against C. difficile TcdB (B9-30 mAb).

SEQ ID NO: 74 corresponds to the amino acid sequence of the CDR2 variable region of the heavy chain of a neutralizing antibody against C. difficile TcdB (B9-30 mAb).

SEQ ID NO: 75 corresponds to the amino acid sequence of the CDR3 variable region of the heavy chain of a neutralizing antibody against C. difficile TcdB (B9-30 mAb).

SEQ ID NO: 76 corresponds to the amino acid sequence of the heavy chain constant region of a neutralizing antibody against C. difficile TcdB (B9-30 mAb).

SEQ ID NO: 77 corresponds to the amino acid sequence of the light chain variable region of a neutralizing antibody against C. difficile TcdB (B9-30 mAb).

SEQ ID NO: 78 corresponds to the amino acid sequence of the light chain variable region signal peptide of a neutralizing antibody against C. difficile TcdB (B9-30 mAb).

SEQ ID NO: 79 corresponds to the amino acid sequence of the CDR1 variable region of the light chain of a neutralizing antibody against C. difficile TcdB (B9-30 mAb).

SEQ ID NO: 80 corresponds to the amino acid sequence of the light chain variable region CDR2 of a neutralizing antibody against C. difficile TcdB (B9-30 mAb).

SEQ ID NO: 81 corresponds to the amino acid sequence of the light chain variable region CDR3 of a neutralizing antibody against C. difficile TcdB (B9-30 mAb).

SEQ ID NO: 82 corresponds to the amino acid sequence of the mutant TcdB, where residues at positions 102, 270, 273, 286, 288, 384, 461, 463, 520, 543, 544, 587, 600, 653, 698 and 751 may be any amino acid.

SEQ ID NO: 83 corresponds to the amino acid sequence of the mutant TcdA with a mutation at positions 269, 272, 285, 287, 460, 462 and 700 compared to SEQ ID NO: 1, in which the methionine residue at position 1 is absent.

SEQ ID NO: 84 corresponds to the amino acid sequence of the mutant C. difficile toxin A with the mutation at positions 285, 287 and 700 compared to SEQ ID NO: 1, in which the methionine residue at position 1 is absent.

SEQ ID NO: 85 corresponds to the amino acid sequence of the mutant C. difficile toxin B mutated at positions 270, 273, 286, 288, 461, 463 and 698 compared to SEQ ID NO: 2, in which the methionine residue at position 1 is absent.

SEQ ID NO: 86 corresponds to the amino acid sequence of the mutant C. difficile toxin B with the mutation at positions 286, 288 and 698 compared to SEQ ID NO: 2, in which the methionine residue at position 1 is absent.

SEQ ID NO: 87 corresponds to the amino acid sequence of C. difficile wild-type TcdA 2004013.

SEQ ID NO: 88 corresponds to the wild type C. difficile TcdA amino acid sequence 2004111.

SEQ ID NO: 89 corresponds to the wild type C. difficile TcdA amino acid sequence 2004118.

SEQ ID NO: 90 corresponds to the wild-type C. difficile TcdA amino acid sequence 2004205.

SEQ ID NO: 91 corresponds to the amino acid sequence of C. difficile wild-type TcdA 2004206.

SEQ ID NO: 92 corresponds to the amino acid sequence of C. difficile wild-type TcdA 2005022.

SEQ ID NO: 93 corresponds to the C. difficile wild-type TcdA amino acid sequence 2005088.

SEQ ID NO: 94 corresponds to the C. difficile wild-type TcdA amino acid sequence 2005283.

SEQ ID NO: 95 corresponds to the amino acid sequence of C. difficile wild-type TcdA 2005325.

SEQ ID NO: 96 corresponds to the wild-type C. difficile TcdA amino acid sequence 2005359.

SEQ ID NO: 97 corresponds to the wild type C. difficile TcdA amino acid sequence 2006017.

SEQ ID NO: 98 corresponds to the C. difficile wild-type TcdA amino acid sequence 2007070.

SEQ ID NO: 99 corresponds to the wild-type C. difficile TcdA amino acid sequence 2007217.

SEQ ID NO: 100 corresponds to the amino acid sequence of C. difficile wild-type TcdA 2007302.

SEQ ID NO: 101 corresponds to the C. difficile wild-type TcdA amino acid sequence 2007816.

SEQ ID NO: 102 corresponds to the C. difficile wild-type TcdA amino acid sequence 2007838.

SEQ ID NO: 103 corresponds to the C. difficile wild-type TcdA amino acid sequence 2007858.

SEQ ID NO: 104 corresponds to the C. difficile wild-type TcdA amino acid sequence 2007886.

SEQ ID NO: 105 corresponds to the wild type C. difficile TcdA amino acid sequence 2008222.

SEQ ID NO: 106 corresponds to the C. difficile wild-type TcdA amino acid sequence 2009078.

SEQ ID NO: 107 corresponds to the C. difficile wild type TcdA amino acid sequence 2009087.

SEQ ID NO: 108 corresponds to the C. difficile wild-type TcdA amino acid sequence 2009141.

SEQ ID NO: 109 corresponds to the C. difficile wild type TcdA amino acid sequence 2009292.

SEQ ID NO: 110 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2004013.

SEQ ID NO: 111 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2004111.

SEQ ID NO: 112 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2004118.

SEQ ID NO: 113 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2004205.

SEQ ID NO: 114 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2004206.

SEQ ID NO: 115 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2005022.

SEQ ID NO: 116 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2005088.

SEQ ID NO: 117 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2005283.

SEQ ID NO: 118 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2005325.

SEQ ID NO: 119 corresponds to the C. difficile wild type TcdB amino acid sequence 2005359.

SEQ ID NO: 120 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2006017.

SEQ ID NO: 121 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2006376.

SEQ ID NO: 122 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2007070.

SEQ ID NO: 123 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2007217.

SEQ ID NO: 124 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2007302.

SEQ ID NO: 125 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2007816.

SEQ ID NO: 126 corresponds to the C. difficile wild type TcdB amino acid sequence 2007838.

SEQ ID NO: 127 corresponds to the C. difficile wild type TcdB amino acid sequence 2007858.

SEQ ID NO: 128 corresponds to the C. difficile wild type TcdB amino acid sequence 2007886.

SEQ ID NO: 129 corresponds to the C. difficile wild type TcdB amino acid sequence 2008222.

SEQ ID NO: 130 corresponds to the C. difficile wild type TcdB amino acid sequence 2009078.

SEQ ID NO: 131 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2009087.

SEQ ID NO: 132 corresponds to the C. difficile wild type TcdB amino acid sequence 2009141.

SEQ ID NO: 133 corresponds to the amino acid sequence of C. difficile wild-type TcdB 2009292.

SEQ ID NO: 134 corresponds to the amino acid sequence of C. difficile wild-type TcdA 014.

SEQ ID NO: 135 corresponds to the amino acid sequence of C. difficile wild-type TcdA 015.

SEQ ID NO: 136 corresponds to the amino acid sequence of C. difficile wild-type TcdA 020.

SEQ ID NO: 137 corresponds to the amino acid sequence of C. difficile wild-type TcdA 023.

SEQ ID NO: 138 corresponds to the amino acid sequence of C. difficile wild-type TcdA 027.

SEQ ID NO: 139 corresponds to the amino acid sequence of C. difficile wild-type TcdA 029.

SEQ ID NO: 140 corresponds to the amino acid sequence of C. difficile wild-type TcdA 046.

SEQ ID NO: 141 corresponds to the amino acid sequence of C. difficile wild-type TcdB 014.

SEQ ID NO: 142 corresponds to the amino acid sequence of C. difficile wild-type TcdB 015.

SEQ ID NO: 143 corresponds to the wild type C. difficile TcdB amino acid sequence 020.

SEQ ID NO: 144 corresponds to the wild type C. difficile TcdB amino acid sequence 023.

SEQ ID NO: 145 corresponds to the amino acid sequence of C. difficile wild-type TcdB 027.

SEQ ID NO: 146 corresponds to the wild type C. difficile TcdB amino acid sequence 029.

SEQ ID NO: 147 corresponds to the amino acid sequence of C. difficile wild-type TcdB 046.

SEQ ID NO: 148 corresponds to the wild type C. difficile 001 TcdA amino acid sequence.

SEQ ID NO: 149 corresponds to the amino acid sequence of C. difficile wild-type TcdA 002.

SEQ ID NO: 150 corresponds to the amino acid sequence of C. difficile wild-type TcdA 003.

SEQ ID NO: 151 corresponds to the amino acid sequence of C. difficile wild-type TcdA 004.

SEQ ID NO: 152 corresponds to the amino acid sequence of C. difficile wild-type TcdA 070.

SEQ ID NO: 153 corresponds to the amino acid sequence of C. difficile wild-type TcdA 075.

SEQ ID NO: 154 corresponds to the amino acid sequence of C. difficile wild-type TcdA 077.

SEQ ID NO: 155 corresponds to the amino acid sequence of C. difficile wild-type TcdA 081.

SEQ ID NO: 156 corresponds to the amino acid sequence of C. difficile 117 wild-type TcdA.

SEQ ID NO: 157 corresponds to the amino acid sequence of C. difficile wild-type TcdA 131.

SEQ ID NO: 158 corresponds to the amino acid sequence of C. difficile wild-type TcdB 001.

SEQ ID NO: 159 corresponds to the amino acid sequence of C. difficile wild-type TcdB 002.

SEQ ID NO: 160 corresponds to the amino acid sequence of C. difficile wild-type TcdB 003.

SEQ ID NO: 161 corresponds to the amino acid sequence of C. difficile wild-type TcdB 004.

SEQ ID NO: 162 corresponds to the amino acid sequence of C. difficile wild-type TcdB 070.

SEQ ID NO: 163 corresponds to the amino acid sequence of C. difficile wild-type TcdB 075.

SEQ ID NO: 164 corresponds to the amino acid sequence of C. difficile wild-type TcdB 077.

SEQ ID NO: 165 corresponds to the amino acid sequence of C. difficile wild-type TcdB 081.

SEQ ID NO: 166 corresponds to the amino acid sequence of C. difficile wild-type TcdB 117.

SEQ ID NO: 167 corresponds to the amino acid sequence of C. difficile wild-type TcdB 131.

SEQ ID NO: 168 corresponds to the amino acid sequence of C. difficile wild-type TcdA 053.

SEQ ID NO: 169 corresponds to the amino acid sequence of C. difficile wild-type TcdA 078.

SEQ ID NO: 170 corresponds to the amino acid sequence of C. difficile wild-type TcdA 087.

SEQ ID NO: 171 corresponds to the amino acid sequence of C. difficile wild-type TcdA 095.

SEQ ID NO: 172 corresponds to the amino acid sequence of C. difficile wild-type TcdA 126.

SEQ ID NO: 173 corresponds to the amino acid sequence of C. difficile wild-type TcdB 053.

SEQ ID NO: 174 corresponds to the amino acid sequence of C. difficile wild-type TcdB 078.

SEQ ID NO: 175 corresponds to the amino acid sequence of C. difficile wild-type TcdB 087.

SEQ ID NO: 176 corresponds to the amino acid sequence of C. difficile wild-type TcdB 095.

SEQ ID NO: 177 corresponds to the amino acid sequence of C. difficile wild-type TcdB 126.

SEQ ID NO: 178 corresponds to the amino acid sequence of C. difficile wild-type TcdA 059.

SEQ ID NO: 179 corresponds to the amino acid sequence of C. difficile wild-type TcdB 059.

SEQ ID NO: 180 corresponds to the amino acid sequence of C. difficile wild-type TcdA 106.

SEQ ID NO: 181 corresponds to the amino acid sequence of C. difficile 106 wild-type TcdB.

SEQ ID NO: 182 corresponds to the amino acid sequence of C. difficile wild-type TcdB 017.

SEQ ID NO: 183 corresponds to the amino acid sequence of the mutant TcdA with a mutation at positions 285, 287, 700, 972 and 978 compared to SEQ ID NO: 1.

SEQ ID NO: 184 corresponds to the amino acid sequence of the mutant TcdB mutated at positions 286, 288, 698, 970 and 976 compared to SEQ ID NO: 2.

Each of SEQ ID NO: 185 - SEQ ID NO: 195 corresponds to the amino acid sequence of an exemplary mutant toxin.

Each of SEQ ID NO: 196 - SEQ ID NO: 212 corresponds to the amino acid sequence of an exemplary mutant toxin A.

Each of SEQ ID NO: 213 - SEQ ID NO: 222 corresponds to the amino acid sequence of an exemplary mutant toxin B.

Each of SEQ ID NO: 223 - SEQ ID NO: 236 corresponds to the amino acid sequence of an exemplary mutant toxin A.

Each of SEQ ID NO: 237 - SEQ ID NO: 243 corresponds to the amino acid sequence of an exemplary mutant toxin B.

Each of SEQ ID NO: 244 - SEQ ID NO: 245 corresponds to the amino acid sequence of an exemplary mutant toxin A.

Each of SEQ ID NO: 246 - SEQ ID NO: 249 corresponds to the amino acid sequence of an exemplary mutant toxin B.

Each of SEQ ID NO: 250 - SEQ ID NO: 253 corresponds to the amino acid sequence of an exemplary mutant toxin A.

SEQ ID NO: 254 corresponds to the amino acid sequence of an exemplary mutant toxin.

Each of SEQ ID NO: 255 - SEQ ID NO: 263 corresponds to the amino acid sequence of an exemplary mutant toxin A.

Each of SEQ ID NO: 264 - SEQ ID NO: 269 corresponds to the amino acid sequence of an exemplary mutant toxin B.

Each of SEQ ID NO: 270 - SEQ ID NO: 275 corresponds to the amino acid sequence of an exemplary mutant toxin.

Each of SEQ ID NO: 276 - SEQ ID NO: 323 corresponds to the amino acid sequence of an exemplary mutant toxin A.

Each of SEQ ID NO: 324 - SEQ ID NO: 373 corresponds to the amino acid sequence of an exemplary mutant toxin B.

Each of SEQ ID NO: 374 - SEQ ID NO: 421 corresponds to the amino acid sequence of an exemplary mutant toxin A.

Each of SEQ ID NO: 422 - SEQ ID NO: 471 corresponds to the amino acid sequence of an exemplary mutant toxin B.

Each of SEQ ID NO: 472 - SEQ ID NO: 519 corresponds to the amino acid sequence of an exemplary mutant toxin A.

Each of SEQ ID NO: 568 - SEQ ID NO: 615 corresponds to the amino acid sequence of an exemplary mutant toxin B.

Each of SEQ ID NO: 520 - SEQ ID NO: 567 corresponds to the amino acid sequence of an exemplary mutant toxin A.

Each of SEQ ID NO: 616 - SEQ ID NO: 663 corresponds to the amino acid sequence of an exemplary mutant toxin B.

Each of SEQ ID NO: 664 - SEQ ID NO: 711 corresponds to the amino acid sequence of an exemplary mutant toxin A.

Each of SEQ ID NO: 712 - SEQ ID NO: 761 corresponds to the amino acid sequence of an exemplary mutant toxin B.

DETAILED DESCRIPTION OF THE INVENTION

The inventors have developed highly immunogenic and well tolerated compositions and methods that can be used to treat, alleviate, reduce the risk of developing and/or prevent C. difficile infection. More specifically, for example, the inventors determined, inter alia, the immunogenicity of a C. difficile vaccine at two dose levels of antigens (toxoid doses of 100 μg and 200 μg total) in a 3-dose schedule (on days 1, 8, and 30) in healthy adults people aged 65-85 years, based on measurement of C. difficile toxin A and toxin B specific neutralizing antibodies on day 37 (7 days after dose 3). The inventors also determined, inter alia, the immunogenicity of a C. difficile vaccine at 2 dose levels of antigens (toxoid total doses of 100 μg and 200 μg) in a 3-dose regimen (at months 0, 1 and 6) in healthy adults aged 65 -85 years, based on measurement of C. difficile toxin A and toxin B specific neutralizing antibodies at month 7 (1 month after dose 3). The inventors also determined, inter alia, the immunogenicity of the C. difficile vaccine at 2 dose levels of antigens (toxoid doses of 100 μg and 200 μg total) in a 3 dose schedule (either on days 1, 8 and 30, or at months 0, 1 and 6) healthy adults aged 65-85 years, based on measurements of C. difficile toxin A and toxin B specific neutralizing antibodies at various time points after vaccination; immune response kinetics in healthy adults aged 65-85 years for at least 12 months after 3 doses of C. difficile vaccine; immunogenicity of the fourth dose of C. difficile vaccine based on measurement of C. difficile toxin A and B toxin specific neutralizing antibodies at various time points post-vaccination; and the kinetics of the immune response in healthy adults aged 65-85 years for at least 36 months after the fourth dose of C. difficile vaccine.

Illustrative compositions are offered. For example, compositions are provided containing an effective amount of C. difficile toxoid A and toxoid B (e.g., about 40 to about 500 μg/dose, e.g., about 40, 50, 60, 70, 80, 90, 100, 1 10, 120 , 130, 140, 1 50, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 450, 460, 470, 480, 490, or 500 µg/dose, e.g., about 50 to about 100 µg/dose (w/w, total toxoids A and B in the composition)), at an effective ratio of toxoids A:B (for example, about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 3:1, 3:2, or 1 :1 toxoid A to toxoid B by weight) and with sufficient purity (for example, at least from about 80 to about 100%, for example, about 80, 85, 90, 95 or 90-100% (w/w)), using one or more administrations (for example, at least two, three administrations or doses) by any suitable route of administration (for example, intramuscularly), with all doses in multiple dose regimens suitably spaced apart in time (e.g., at least about one to about ten days apart, e.g., about one, two, three, four, five, six, seven, eight, nine, or ten, e.g., approximately seven days). The amount of time (time interval) between doses, as will be understood by those skilled in the art, may vary depending on the individual, and such interval should be long enough (e.g., measured in days) so that an immune response from a previous dose can develop (e.g., be primed) and was not inhibited in any way by a subsequent dose (eg booster dose or doses).

In one embodiment, the composition used in the vaccination regimen of the present invention contains from about 40 to about 500 μg/dose of C. difficile toxoid A. In one embodiment, the composition contains from about 50 to about 400 μg/dose of C. difficile toxoid A. In one embodiment, the composition contains from about 50 to about 200 micrograms/dose of C. difficile toxoid A. In one embodiment, the composition contains from about 50 to about 150 micrograms/dose. In one embodiment, the composition contains about 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250 , 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 450, 460, 470, 480, 490 or 500 mcg/dose of C. difficile toxoid A. In one embodiment, the composition contains about 50 μg/dose of C. difficile toxoid A. In another embodiment, the composition contains about 100 μg/dose of C. difficile toxoid A.

In one embodiment, the composition used in the vaccination regimen of the present invention contains from about 40 to about 500 μg/dose of C. difficile toxoid B. In one embodiment, the composition contains from about 50 to about 400 micrograms/dose of C. difficile toxoid B. In one embodiment, the composition contains from about 50 to about 200 micrograms/dose of C. difficile toxoid B. In one embodiment, the composition contains from about 50 to about 150 micrograms/dose. In one embodiment, the composition contains about 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250 , 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 450, 460, 470, 480, 490 or 500 mcg/dose of C. difficile toxoid B. In one embodiment, the composition contains about 50 μg/dose of C. difficile toxoid B. In another embodiment, the composition contains about 100 μg/dose of C. difficile toxoid B.

In one embodiment, the composition used in the vaccination regimen of the present invention contains C. difficile toxoid A and B at the doses disclosed herein. In one embodiment, the ratio of toxoids A and B is 3:1, 3:2, or 1:1 of toxoid A to toxoid B by weight. In one embodiment, the ratio of toxoids A and B is 1:3, 2:3, or 1:1 of toxoid A to toxoid B by weight. In one embodiment, the ratio of toxoids A and B is 1:1 toxoid A to toxoid B by weight.

In one embodiment, the composition used in the vaccination regimen of the present invention contains C. difficile toxoids A and B in a purity of at least about 80% to about 100%. In one embodiment, the composition used in the vaccination regimen of the present invention contains C. difficile toxoids A and B in a purity of at least about 90% to about 100%. In one embodiment, the composition used in the vaccination regimen of the present invention contains C. difficile toxoids A and B in a purity of about 80%, 85%, 90%, 95%, or 100% (w/w).

In one embodiment, the compositions disclosed herein are administered once. In one embodiment, the compositions disclosed herein are administered twice. In one embodiment, the compositions disclosed herein are administered three times. In one embodiment, the compositions disclosed herein are administered four times.

In one embodiment, the compositions disclosed herein are administered twice at the same dose. In one embodiment, the compositions disclosed herein are administered three times at the same dose. In one embodiment, the compositions disclosed herein are administered four times at the same dose.

In one embodiment, the composition of the present invention is administered by any suitable route of administration. In one embodiment, the compositions disclosed herein are administered by intramuscular, intraperitoneal, intradermal, or subcutaneous routes of administration. In one embodiment, the compositions disclosed herein are administered subcutaneously or intramuscularly. In one embodiment, the compositions disclosed herein are administered intramuscularly.

In one embodiment of the present invention, all doses in a multi-dose regimen are appropriately spaced in time. In one embodiment, the compositions disclosed herein are administered twice, with all doses separated by an interval of from about one to about ten days. In one embodiment, the compositions disclosed herein are administered twice, with all doses separated by an interval of from about two to nine days. In one embodiment, the compositions disclosed herein are administered twice, with all doses separated by an interval of about one, two, three, four, five, six, seven, eight, nine, or ten days. In one embodiment, the compositions disclosed herein are administered twice, with all doses separated by an interval of about six days. In one embodiment, the compositions disclosed herein are administered twice, with all doses separated by an interval of about seven days. In one embodiment, the compositions disclosed herein are administered twice, with all doses separated by an interval of about eight days. In one embodiment, the compositions disclosed herein are administered twice, with all doses separated by an interval of from about one to about four months. In one embodiment, the compositions disclosed herein are administered twice, with all doses separated by an interval of about one, two, three, or four months. In one embodiment, the compositions disclosed herein are administered twice, with all doses separated by an interval of about one month. In one embodiment, the compositions disclosed herein are administered twice, with all doses separated by an interval of about two months.

In one embodiment, the compositions disclosed herein are administered three times, with the first and second doses separated by an interval of about one to about ten days, and the third dose and the first dose separated by an interval of about 15-45 days. In one embodiment, the compositions disclosed herein are administered three times, with the first and second doses separated by an interval of about 5 to about 8 days, and the third dose from the first dose separated by an interval of about 20-35 days. In one embodiment, the compositions disclosed herein are administered three times, with the first and second doses separated by an interval of about 6 to about 7 days, and the third dose from the first dose separated by an interval of about 25-35 days. In one embodiment, the compositions disclosed herein are administered three times, with the first and second doses separated by an interval of about seven days, and the third dose from the first dose separated by an interval of about 30 days.

In one embodiment, the compositions disclosed herein are administered three times, with the first and second doses separated by an interval of about one to about four months, and the third dose and the first dose separated by an interval of about 5-10 months. In one embodiment, the compositions disclosed herein are administered three times, with the first and second doses separated by an interval of about one to two months, and the third dose and the first dose separated by an interval of about 5-8 months. In one embodiment, the compositions disclosed herein are administered three times, with the first and second doses separated by an interval of about one month, and the third dose from the first dose separated by an interval of about 6 months. In one embodiment, the compositions disclosed herein are administered three times, with the first and second doses separated by an interval of about one month, and the third dose from the first dose separated by an interval of about 5 months. In one embodiment, the compositions disclosed herein are administered three times, with the first and second doses separated by an interval of about one month, and the third dose from the first dose separated by an interval of about 7 months.

In one embodiment, the compositions disclosed herein are administered four times, with the first and second doses separated by an interval of about one to about ten days, the third dose and the first dose separated by an interval of about 15-45 days, and the fourth the dose is separated from the third dose by an interval of about 6 months to about 2 years. In one embodiment, the compositions disclosed herein are administered four times, with the first and second doses separated by an interval of about 5 to about 8 days, the third dose and the first dose separated by an interval of about 20-35 days, and the fourth the dose is separated from the third dose by an interval of about 10 months to about 1.5 years. In one embodiment, the compositions disclosed herein are administered four times, with the first and second doses separated by an interval of about 6 to about 7 days, the third dose and the first dose separated by an interval of about 25-35 days, and the fourth the dose is separated from the third dose by an interval of about 11 months to about 13 months. In one embodiment, the compositions disclosed herein are administered four times, with the first and second doses separated by an interval of about seven days, the third dose and the first dose separated by an interval of about 30 days, and the fourth dose and the third dose separated by an interval of about 30 days. constituting 1 year.

In one embodiment, the compositions disclosed herein are administered four times, with the first and second doses separated by an interval of about one to about four months, the third dose and the first dose separated by an interval of about 5-10 months, and the fourth dose with the third dose separated by an interval of from about 6 months to 2 years. In one embodiment, the compositions disclosed herein are administered four times, with the first and second doses separated by an interval of about one to two months, the third dose and the first dose separated by an interval of about 5-8 months, and the fourth dose with the third dose separated by an interval of from about 10 months to 1.5 years. In one embodiment, the compositions disclosed herein are administered four times, with the first and second doses separated by an interval of about one month, the third dose with the first dose separated by an interval of about 6 months, and the fourth dose with the third dose separated by an interval of about 6 months. , ranging from about 11 months to 13 months. In one embodiment, the compositions disclosed herein are administered four times, with the first and second doses separated by an interval of about one month, the third dose with the first dose separated by an interval of about 6 months, and the fourth dose with the third dose separated by an interval of about 6 months. , which is approximately 12 months.

In one embodiment, compositions administered in any of the multiple dose regimens disclosed herein are administered at the same dose (ie, the same amount of C. difficile toxoid A and/or B). In one embodiment, the compositions administered in any of the multiple dose regimens disclosed herein are the same (i.e., the same dose and the same ingredients).

In one embodiment, compositions administered in any of the multiple dose regimens disclosed herein are administered at different doses. In one embodiment, compositions administered in any of the multiple dose regimens disclosed herein are administered at the same dose of antigens (i.e., the same amount of C. difficile toxoid A and/or B), but they may contain different ingredients (eg different adjuvants).

In some embodiments, the second administration is at least one, two, three, four, five, six, seven, eight, nine, or ten days after the first administration (e.g., day 0), and the third administration is at least about 20-200 (e.g., about 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, or 200, e.g., about 30 or approximately 180 days) days after the first administration. For example, the method may include first, second, and/or third administrations, wherein the second administration is at least 7 days after the first administration, and the third administration is at least about 30 days and/or at least about 180 days after first or second injection. In some embodiments, the second injection is given about seven days after the first injection, and the third injection is given about 30 days after the first injection.

Upon administration of such compositions using such methods to a host/subject, an immune response is typically observed, which typically includes a humoral immune response and may include a cellular immune response.

In specific embodiments, the method may include administering the immunogenic composition to a human, a subject at risk of developing an infection. In some embodiments, the human subject may be at least about 40, 50, 65 years of age, or older. In some embodiments, the human subject may be between about 40 and about 65 years of age. In some embodiments, the implementation of the subject-human may be aged 65-75 years. Thus, methods of administering the compositions are also provided. Methods for preparing the compositions are described herein and are known to those skilled in the art.

In one aspect, the invention provides methods for immunizing a subject (eg, a human) against C. difficile by administering to it a composition comprising one or more C. difficile antigens. In one aspect, the invention relates to a composition disclosed herein for use in a method of immunizing a subject against C. difficile . In one aspect, the invention relates to a composition disclosed herein for use in a method of immunizing a subject against C. difficile . In one embodiment, the human subject is 40-90 years of age. In one embodiment, the human subject is between 50 and 85 years of age. In one embodiment, the human subject is 60-85 years of age. In one embodiment, the human subject is 65-85 years of age. In one embodiment, the human subject is 65-69 years of age. In one embodiment, the human subject is 70-79 years of age. In one embodiment, the human subject is 75-79 years of age. In one embodiment, the human subject is at least 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, or 90 years old. In one embodiment, the human subject is at least 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84 or 85 years old.

For example, a suitable composition may contain a total of about 50 or about 100 micrograms (or about 50-100 micrograms) of C. difficile toxoids (toxoid A and toxoid B) with an approximate ratio of toxoid A to toxoid B of about 3:2, with the addition of or without the addition of an adjuvant (eg aluminum hydroxide). For purposes of comparison, an antigen containing composition may be administered to one group of subjects and a placebo composition (eg, 0.9% normal saline) administered (eg, in the same manner) to another group. Immunological and safety data can be obtained from subjects on specific days (eg, days 0, 14, 30, 60, 180 and/or 210, and/or up to 1000 days after the first injection). Administration of the composition may be, for example, on day 0 (first administration), around day 7 (second administration), around day 30 (third administration) and/or around day 180 (alternative third administration or fourth administration).

The composition may contain C. difficile toxoid A and toxoid B in an effective ratio of toxoid A:B (e.g., about 3:1, 3:2, or 1:1 toxoid A to toxoid B, by weight) of sufficient purity (e.g., about 90% pure). % or higher (w/w)). For example, the composition may contain a highly purified (eg, >90% (w/w/)) preparation of C. difficile toxoids A and B with an approximate ratio of toxoid A to toxoid B of about 3:2. Such compositions can be prepared using any of the suitable preparation methods, such as those described in WIPO patent application WO/2012/143902, US patent No. 9187536 and WIPO patent application WO/2014/060898, all of which are incorporated herein by reference in in full.

As used herein, the term " C. difficile toxoid" means a C. difficile toxin (toxin A or toxin B) that has been partially or completely inactivated. A toxin is inactivated if it has less toxicity (e.g., 100%, 99%, 98%, 80%, 70%, 60%, 50%, 40%, 30%, 20%, 10% or less toxicity, including any intermediate value) than the untreated toxin when measured, for example, in an in vitro cytotoxicity assay or in an animal toxicity assay. C. difficile toxoids can be obtained by purifying toxins from C. difficile cultures and chemically inactivating the toxins (eg, by treatment with formaldehyde, glutaraldehyde, peroxide, or oxygen). Alternatively, wild-type or mutant C. difficile toxins that have no, or reduced, toxicity can be generated using recombinant techniques and/or, alternatively, chemical crosslinkers. For example, genetic mutations can be introduced resulting in reduced toxicity. Wild-type or mutant C. difficile toxins can also be produced, stripped of certain regions to reduce toxicity.

A C. difficile toxoid, or mutant C. difficile toxin, is a molecule having a structure, or sequence, that differs from the corresponding wild-type structure or sequence, for example, the presence of crosslinks compared to the corresponding wild-type structure, and/or the presence of at least one mutation compared to the corresponding wild-type sequence when optimally aligned, for example, using the GAP or BESTFIT program using the default deletion penalty. The toxoid or mutant toxin described herein also has a functional property (eg, missing glucosyl transferase activity and/or missing cysteine protease activity) that differs from the corresponding property of the wild-type molecule.

The toxoid described herein may be any of the toxoids, or mutant toxins,C. difficiledescribed in WIPO Patent Application WO/2012/143902, US Patent No. 9187536 and WIPO Patent Application WO/2014/060898, all of which are incorporated herein by reference in their entirety. That is, the toxoid described herein may be any of the polypeptides described in WIPO patent application WO/2012/143902, US patent No. 9187536 and WIPO patent application WO/2014/060898, all of which are incorporated herein by links in full. ToxinC. difficilefrom any of the wild-type strains described above can be used as a source for obtaining a toxoid, or a mutant toxin,C. difficile. Preferably,C. difficile630 is the source from which the toxoid is obtainedC. difficile.

In one embodiment, the toxoid is a polypeptide having any sequence selected from SEQ ID NO: 1 - SEQ ID NO: 761, while lacking an initial methionine residue, and the polypeptide has been treated with a chemical crosslinking agent, such as, for example, formaldehyde or EDC as described herein and/or has been genetically mutated. More specifically, in one embodiment, the toxoid is a polypeptide having the amino acid sequence shown in any of SEQ ID NOs: 1-8, 15, 17, 19, 21, 23, 25, 28-35, 82-761.

The mutation may include a substitution, deletion, truncation, or modification of the wild-type amino acid residue normally found at that position. Preferably, the mutation is a non-conservative amino acid substitution. The mutant toxins of the invention can be produced by methods known in the art for generating mutations, such as, for example, site-directed mutagenesis, mutagen-assisted mutagenesis (eg, UV light), and so on. Preferably, site-directed mutagenesis is used. Alternatively, a nucleic acid molecule having the appropriate sequence can be directly synthesized. Such chemical synthesis methods are known in the art.

The mutant C. difficile toxin of the present invention has at least one mutation in the glucosyltransferase domain compared to the corresponding wild-type C. difficile toxin. In one embodiment, the glucosyltransferase domain has at least two mutations. Preferably, the mutation results in a reduction or elimination of the enzymatic glucosyl transferase activity of the toxin compared to the enzymatic glucosyl transferase activity of the corresponding C. difficile wild-type toxin.

An exemplary C. difficile toxoid A has a glucosyltransferase domain comprising SEQ ID NO: 29 having an amino acid substitution at positions 285 and 287 and a cysteine protease domain comprising SEQ ID NO: 32 having an amino acid substitution at position 158, relative to the corresponding wild A toxin. type C. difficile . For example, such a mutant C. difficile TcdA has the amino acid sequence shown in SEQ ID NO: 4, in which the initial methionine residue is missing. In another embodiment, the mutant C. difficile toxin A has the amino acid sequence shown in SEQ ID NO: 84. Additional examples of C. difficile toxoid A include the amino acid sequence shown in SEQ ID NO: 7, which has mutations D269A, R272A, D285A, D287A, E460A, R462A and C700A compared to SEQ ID NO: 1, in which the initial methionine residue is optionally absent. In another embodiment, the mutant C. difficile toxin A has the amino acid sequence shown in SEQ ID NO: 83.

An exemplary C. difficile toxoid B has the amino acid sequence shown in SEQ ID NO: 6, in which the initial methionine residue is absent. In another embodiment, the mutant C. difficile toxin B has the amino acid sequence shown in SEQ ID NO: 86. Additional examples of the mutant C. difficile TcdB include the amino acid sequence shown in SEQ ID NO: 8, which has the mutations D270A, R273A, D286A, D288A, D461A, K463A and C698A compared to SEQ ID NO: 2, and optionally no initial methionine residue in SEQ ID NO: 8. In another embodiment, the mutant C. difficile toxin B has the amino acid sequence shown in SEQ ID NO: 85.

In addition to inducing an immune response in a mammal, the toxoids described herein also have reduced cytotoxicity compared to the corresponding C. difficile wild-type toxin. Preferably, the immunogenic compositions are safe and have minimal (eg, about 6-8 log ₁₀ reduction), or no, cytotoxicity compared to that of the corresponding wild-type toxin when administered to mammals.

As used herein, the term "cytotoxicity" is a term accepted in the art and refers to apoptotic cell death and/or a condition in which one or more normal biochemical or biological functions of a cell are aberrantly impaired compared to the functions of an identical cell under identical conditions, but in the absence of a cytotoxic agent. Toxicity can be quantified, for example, in cells or in mammals, as the amount of agent needed to induce 50% cell death (ie, EC ₅₀ or ED ₅₀ , respectively) or by other methods known in the art.

Assays for determining cytotoxicity are known in the art, such as cell rounding assays. Additional illustrative cytotoxicity assays known in the art include glucosylation assays associated with imaging on a luminescent phosphor coating of Ras labeled with [ ¹⁴ C]glucose and, preferably, an in vitro cytotoxicity assay as described in WIPO patent application WO/2012/143902 , US Pat. No. 9,187,536 and WIPO Patent Application WO/2014/060898, all of which are incorporated herein by reference in their entirety, wherein EC ₅₀ may mean the concentration of an immunogenic composition that results in a cytopathogenic effect for at least about 50% cells (CPE), preferably diploid human fibroblasts (e.g., IMR90 cells (ATCC CCL-186™), compared to identical cells under identical conditions in the absence of toxin. In vitro cytotoxicity assay can also be used to assess the concentration of the composition resulting in inhibition C. difficile toxin-induced cytopathogenic effect (CPE) for at least about 50% of cells, preferably diploid human fibroblasts (eg, IMR90 cells (ATCC CCL-186™), compared to identical cells under identical conditions in the absence of toxin.

In one embodiment, the cytotoxicity of the immunogenic composition is reduced by at least about 1000, 2000, 3000, 4000, 5000, 6000, 7000, 8000, 9000, 10000, 11000, 12000, 13000 times, 14000 times, 15000 times, or more, compared with the corresponding C. difficile wild-type toxin.

In another embodiment, the cytotoxicity of the immunogenic composition is reduced by at least about 2-log ₁₀ , more preferably about 3-log ₁₀ , and most preferably about 4-log ₁₀ , or more, when compared to the corresponding wild-type toxin in identical conditions. For example, mutant C. difficile TcdB may have an EC ₅₀ value of about 10 ^-9 g/mL as measured in a standard cytopathogenic effect (CPE) assay, compared to exemplary C. difficile wild-type TcdB, which may have an EC ₅₀ value of at least about 10 ^-12 g/ml.

In another embodiment, the cytotoxicity of the mutant C. difficile toxin is characterized by an EC ₅₀ of at least about 50 μg/ml, 100 μg/ml, 200 μg/ml, 300 μg/ml, 400 μg/ml, 500 μg/ml, 600 μg/ml. ml, 700 μg/ml, 800 μg/ml, 900 μg/ml, 1000 μg/ml, or more, when measured, for example, in an in vitro cytotoxicity assay. Accordingly, in a preferred embodiment, the immunogenic compositions and mutant toxins are biologically safe for administration to mammals.

In one embodiment, the toxoid is a polypeptide having any sequence selected from SEQ ID NO: 1 - SEQ ID NO: 761, more specifically, the toxoid is a polypeptide having the amino acid sequence shown in any of SEQ ID NO: 1-8 , 15, 17, 19, 21, 23, 25, 28-35, 82-761, in which the initial methionine residue is absent, and the polypeptide has been treated with a chemical cross-linking agent such as, for example, formaldehyde or EDC, as described in this document. Crosslinking (also referred to herein as "chemical inactivation" or "inactivation") is the process of chemically joining two or more molecules by a covalent bond. The terms "crosslinkers", "crosslinkers" and "crosslinkers" mean molecules capable of reacting and/or chemically bonding with specific functional groups (primary amines, sulfhydryls, carboxyls, carbonyls, etc.) on peptides, polypeptides, and/or proteins. In one embodiment, the molecule may contain two or more reactive ends that can react and/or chemically bond with specific functional groups (primary amines, sulfhydryls, carboxyls, carbonyls, and so on) on peptides, polypeptides, and/or proteins. Preferably, the chemical crosslinker is water soluble. In another preferred embodiment, the chemical crosslinker is a heterobifunctional crosslinker. In another embodiment, the chemical crosslinker is not a heterobifunctional crosslinker. Chemical crosslinkers are known in the art.

Illustrative suitable chemical crosslinkers include formaldehyde; formalin; acetaldehyde; propionaldehyde; water-soluble carbodiimides (RN=C=NR'), which include 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 1-cyclohexyl-3-( 2-morpholinyl-(4-ethyl)carbodiimide metho-p-toluenesulfonate (CMC), N,N'-dicyclohexylcarbodiimide (DCC) and N,N'-diisopropylcarbodiimide (DIC) and their derivatives; and N-hydroxysuccinimide (NHS ); phenylglyoxal; and/or UDP-dialdehyde.

Preferably, the crosslinking agent is an EDC. When the mutant C. difficile toxin polypeptide is chemically modified with EDC (e.g., by treating the EDC polypeptide), in one embodiment, the polypeptide has (a) at least one cross-link between the side chain of the aspartic acid residue of the polypeptide and the side chain of the lysine residue of the polypeptide. In one embodiment, the polypeptide has (b) at least one cross-link between the side chain of a glutamic acid residue of the polypeptide and the side chain of a lysine residue of the polypeptide. In one embodiment, the polypeptide has (c) at least one crosslink between the carboxyl group at the C-terminus of the polypeptide and the amino group at the N-terminus of the polypeptide. In one embodiment, the polypeptide has (d) at least one crosslink between the carboxyl group at the C-terminus of the polypeptide and the side chain of a lysine residue of the polypeptide. In one embodiment, the polypeptide has (e) at least one cross-link between the side chain of the aspartic acid residue of the polypeptide and the side chain of the lysine residue of the second isolated polypeptide. In one embodiment, the polypeptide has (f) at least one cross-link between the side chain of the glutamic acid residue of the polypeptide and the side chain of the lysine residue of the second isolated polypeptide. In one embodiment, the polypeptide has (g) at least one crosslink between the carboxyl group at the C-terminus of the polypeptide and the amino group at the N-terminus of the second isolated polypeptide. In one embodiment, the polypeptide has (h) at least one crosslink between the carboxyl group at the C-terminus of the polypeptide and the side chain of the lysine residue of the second isolated polypeptide.

"Second isolated polypeptide" means any isolated polypeptide present during the reaction with the EDC. In one embodiment, the second isolated polypeptide is a C. difficile toxin mutant polypeptide having a sequence identical to that of the first isolated polypeptide. In another embodiment, the second isolated polypeptide is a mutant C. difficile toxin polypeptide having a sequence different from that of the first isolated polypeptide.

In one embodiment, the polypeptide has at least two modifications selected from modifications (a)-(d). In an exemplary embodiment, the polypeptide has (a) at least one cross-link between the side chain of the aspartic acid residue of the polypeptide and the side chain of the lysine residue of the polypeptide, and (b) at least one linkage between the side chain of the glutamic acid residue of the polypeptide and the side chain of the lysine residue of the polypeptide. In the following embodiment, the polypeptide has at least three modifications selected from modifications (a)-(d). In the following embodiment, the polypeptide has modifications (a), (b), (c) and (d).

If more than one mutant polypeptide is present in the process of chemical modification by EDC, in one embodiment, the resulting composition has at least one of the modifications (a)-(h). In one embodiment, the composition has at least two modifications selected from modifications (a)-(h). In the following embodiment, the composition has at least three modifications selected from modifications (a)-(h). In the following embodiment, the composition has at least four modifications selected from modifications (a)-(h). In another embodiment, the composition has at least one of all modifications (a)-(h).

In an exemplary embodiment, the resulting composition has (a) at least one crosslink between the side chain of the aspartic acid residue of the polypeptide and the side chain of the lysine residue of the polypeptide; and (b) at least one cross-link between the side chain of a glutamic acid residue of the polypeptide and the side chain of a lysine residue of the polypeptide. In one embodiment, the composition also has (c) at least one crosslink between the carboxyl group at the C-terminus of the polypeptide and the amino group at the N-terminus of the polypeptide; and (d) at least one crosslink between the carboxyl group at the C-terminus of the polypeptide and the side chain of a lysine residue of the polypeptide.

In another exemplary embodiment, the resulting composition has (e) at least one crosslink between the side chain of the aspartic acid residue of the polypeptide and the side chain of the lysine residue of the second isolated polypeptide; (f) at least one crosslink between the side chain of the glutamic acid residue of the polypeptide and the side chain of the lysine residue of the second isolated polypeptide; (g) at least one crosslink between the carboxyl group at the C-terminus of the polypeptide and the amino group at the N-terminus of the second isolated polypeptide; and (h) at least one crosslink between the carboxyl group at the C-terminus of the polypeptide and the side chain of the lysine residue of the second isolated polypeptide.

In the following exemplary embodiment, the resulting composition has (a) at least one crosslink between the side chain of the aspartic acid residue of the polypeptide and the side chain of the lysine residue of the polypeptide; (b) at least one crosslink between the side chain of the glutamic acid residue of the polypeptide and the side chain of the lysine residue of the polypeptide; (e) at least one crosslink between the side chain of the aspartic acid residue of the polypeptide and the side chain of the lysine residue of the second isolated polypeptide; and (f) at least one crosslink between the side chain of the glutamic acid residue of the polypeptide and the side chain of the lysine residue of the second isolated polypeptide.

In a preferred embodiment, the chemical crosslinking agent comprises formaldehyde, more preferably the reagent comprises formaldehyde in the absence of lysine. Glycine or other suitable primary amine compound can be used as a quencher in crosslinking reactions. Accordingly, in another preferred embodiment, the chemical reagent comprises formaldehyde using glycine.

In another preferred embodiment, the chemical crosslinker comprises EDC and NHS. As is known in the art, NHS can be included in crosslinking protocols using EDC. However, the inventors unexpectedly found that NHS can further reduce the cytotoxicity of the mutant C. difficile toxin compared to the corresponding wild-type toxin, compared to the genetically modified toxin, and compared to the genetically modified toxin that was chemically cross-linked using EDC. See, for example, Example 22 described in WIPO Patent Application WO/2012/143902, US Patent No. 9187536 and WIPO Patent Application WO/2014/060898, all of which are incorporated herein by reference in their entirety. Accordingly, without being bound by mechanism or theory, a mutant toxin polypeptide having a beta-alanine moiety linked to the side chain of at least one lysine residue of the polypeptide (e.g., as a result of the reaction of the mutant toxin polypeptide, EDC and NHS) may have further reduced cytotoxicity. mutant toxin compared to, for example, a C. difficile toxin (wild-type or mutant) that lacks a beta-alanine moiety.

The use of EDC and/or NHS may also include the use of glycine, or other suitable primary amine compound, as the quencher. The quencher can be any compound having a primary amine, such as, for example, the methyl ester of glycine and alanine. In a preferred embodiment, the quencher compound is a non-polymeric hydrophilic primary amine. Examples of the non-polymeric hydrophilic primary amine include, for example, amino sugars, amino alcohols and amino polyols. Specific examples of a non-polymeric hydrophilic primary amine include glycine, ethanolamine, glucamine, amine-functionalized polyethylene glycol, and amine-functionalized ethylene glycol oligomers. In one embodiment, the chemical crosslinker does not include formaldehyde. In one embodiment, the chemical crosslinker does not include formalin.

In one aspect, the invention relates to a mutant toxin, ie, a polypeptide, of C. difficile having at least one amino acid side chain chemically modified with EDC and a non-polymeric hydrophilic primary amine, preferably glycine. The resulting glycine adducts (eg, from the production of triply mutant toxins from EDC, NHS, and glycine quench) may help reduce the cytotoxicity of the mutant toxin compared to the corresponding wild-type toxin.

In one embodiment, when a mutant toxin, i.e., a polypeptide, of C. difficile is chemically modified with EDC and glycine, the polypeptide has at least one modification by modifying the polypeptide with EDC (e.g., at least one of any of the modifications ( a)-(h) described above), and at least one of the following exemplary modifications: (i) a glycine moiety linked to a carboxyl group at the C-terminus of the polypeptide; (j) a glycine moiety linked to the side chain of at least one aspartic acid residue of the polypeptide; and (k) a glycine moiety linked to the side chain of at least one glutamic acid residue of the polypeptide.

In one embodiment, at least one amino acid of the mutant TcdA, ie, polypeptide, C. difficile is chemically cross-linked and/or at least one amino acid of the mutant TcdB, ie, polypeptide, C. difficile is chemically cross-linked. Any of the mutant toxins, that is, the polypeptides described herein, can be chemically crosslinked. In another embodiment, at least one amino acid of a polypeptide having SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 7, and/or SEQ ID NO: 8 is chemically crosslinked. In one embodiment, at least one amino acid residue of a polypeptide having any amino acid sequence from SEQ ID NO: 1 - SEQ ID NO: 761 is crosslinked. For example, in one embodiment, at least one amino acid residue of a polypeptide having the amino acid sequence shown in any of SEQ ID NOs: 1-8, 15, 17, 19, 21, 23, 25, 28-35, 82-761, is stitched. In another embodiment, at least one amino acid residue of a polypeptide having any amino acid sequence from SEQ ID NO: 183 - SEQ ID NO: 761 has the modification described above, for example, any of the modifications (a)-(k), for example, (a) at least one link between the side chain of the aspartic acid residue of the polypeptide and the side chain of the lysine residue of the polypeptide.

For example, at least one amino acid may be chemically cross-linked with an agent that includes a carbodiimide, such as EDC. Carbodiimides can cause the formation of a covalent bond between the free carboxyl (eg, from the side chains of aspartic acid and/or glutamic acid) and amino groups (eg, in the side chain of lysine residues), creating stable amide bonds.

As another example, at least one amino acid can be chemically cross-linked with a reagent that includes NHS. Activated NHS ester crosslinkers can react with primary amines (eg, at the N-terminus of each polypeptide chain and/or at the side chain of lysine residues) to form an amide bond.

In another embodiment, at least one amino acid can be chemically crosslinked with a reagent that includes EDC and NHS. For example, in one embodiment, the invention relates to an isolated polypeptide having the amino acid sequence shown in SEQ ID NO: 4, in which the methionine residue at position 1 is optionally absent, while the polypeptide has at least one amino acid side chain chemically modified with EDC and NHS. In another embodiment, the invention relates to an isolated polypeptide having the amino acid sequence shown in SEQ ID NO: 6, in which the methionine residue at position 1 is optionally absent, while the polypeptide has at least one amino acid side chain chemically modified with EDC and NHS. In another embodiment, the invention relates to an isolated polypeptide having the amino acid sequence shown in SEQ ID NO: 84, SEQ ID NO: 86, SEQ ID NO: 83, SEQ ID NO: 85, SEQ ID NO: 7, or SEQ ID NO : 8. Polypeptide modified by processing the polypeptide with EDC and NHS.

If the mutant toxin, i.e., C. difficile polypeptide, is chemically modified (e.g., by treatment) with EDC and NHS, in one embodiment, the polypeptide has at least one modification by EDC modification of the polypeptide (e.g., at least one of modifications (a)-(h) described above) and (l) a beta-alanine fragment linked to the side chain of at least one lysine residue of the polypeptide.

In another aspect, the invention relates to a mutant toxin, i.e., a polypeptide, C. difficile , wherein the polypeptide has at least one amino acid side chain chemically modified with EDC, NHS and a non-polymeric hydrophilic primary amine, preferably glycine. In one embodiment, the polypeptide has at least one modification when the polypeptide is modified with EDC (e.g., at least one of modifications (a)-(h) described above), at least one modification when the polypeptide is modified with glycine (for example, at least one of the modifications (i)-(k) described above); and (l) a beta-alanine fragment associated with the side chain of at least one lysine residue of the polypeptide.

In one aspect, the invention relates to a mutant toxin, ie, a polypeptide, of C. difficile in which the side chain of at least one lysine residue of the polypeptide is linked to a beta-alanine moiety. In one embodiment, the side chain of the second lysine residue of the polypeptide is linked to the side chain of an aspartic acid residue and/or to the side chain of a glutamic acid residue. A "second" lysine residue of a polypeptide includes a lysine residue of a polypeptide that is not associated with a beta-alanine moiety. The aspartic acid side chain and/or the glutamic acid side chain to which the second lysine residue is linked may be an intramolecular crosslinking sidechain of a polypeptide or an intermolecular crosslinking sidechain of a second polypeptide. In another embodiment, the side chain of at least one aspartic acid residue and/or the side chain of at least one glutamic acid residue of the polypeptide is linked to a glycine moiety. An aspartic acid residue and/or a glutamic acid residue that is associated with a glycine moiety is also not associated with a lysine residue.

In another aspect, the invention relates to a mutant toxin, ie, a polypeptide, C. difficile in which at least one amino acid side chain of the wild type C. difficile toxin is chemically modified. In one embodiment, at least one wild-type C. difficile toxin A amino acid side chain and/or at least one wild-type C. difficile toxin B amino acid side chain is chemically modified with EDC. For example, in one embodiment, TcdA (SEQ ID NO: 1) and/or Tcdb (SEQ ID NO: 2) is chemically modified with EDC. In another embodiment, the wild-type toxin is chemically modified with EDC and NHS. In one embodiment, the mutant toxin, i.e., the polypeptide, comprises a chemically modified wild-type toxin A, wherein the wild-type toxin A is any of those listed in Table 1. In another embodiment, the mutant toxin, i.e., the polypeptide, comprises a chemically modified toxin B wild-type, with wild-type B toxin being any of those listed in Table 2.

Table 1: Strains C. difficile wild type C. difficile strain Toxin A, SEQ ID NO: 2004013 SEQ ID NO: 87 2004111 SEQ ID NO: 88 2004118 SEQ ID NO: 89 2004205 SEQ ID NO: 90 2004206 SEQ ID NO: 91 2005022 SEQ ID NO: 92 2005088 SEQ ID NO: 93 2005283 SEQ ID NO: 94 2005325 SEQ ID NO: 95 2005359 SEQ ID NO: 96 2006017 SEQ ID NO: 97 2006376 N/A 2007070 SEQ ID NO: 98 2007217 SEQ ID NO: 99 2007302 SEQ ID NO: 100 2007816 SEQ ID NO: 101 2007838 SEQ ID NO: 102 2007858 SEQ ID NO: 103 2007886 SEQ ID NO: 104 2008222 SEQ ID NO: 105 2009078 SEQ ID NO: 106 2009087 SEQ ID NO: 107 2009141 SEQ ID NO: 108 2009292 SEQ ID NO: 109 001 SEQ ID NO: 148 002 SEQ ID NO: 149 003 SEQ ID NO: 150 012 (004) SEQ ID NO: 151 014 SEQ ID NO: 134 015 SEQ ID NO: 135 017 020 SEQ ID NO: 136 023 SEQ ID NO: 137 027 SEQ ID NO: 138 029 SEQ ID NO: 139 046 SEQ ID NO: 140 053 SEQ ID NO: 168 059 SEQ ID NO: 178 070 SEQ ID NO: 152 075 SEQ ID NO: 153 077 SEQ ID NO: 154 078 SEQ ID NO: 169 081 SEQ ID NO: 155 087 SEQ ID NO: 170 095 SEQ ID NO: 171 106 SEQ ID NO: 180 117 SEQ ID NO: 156 126 SEQ ID NO: 172 131 SEQ ID NO: 157 SE844 SEQ ID NO: 196 12087 SEQ ID NO: 197 K14 SEQ ID NO: 198 BI6 SEQ ID NO: 199 BI17 SEQ ID NO: 200 CH6230 SEQ ID NO: 201 SE881 SEQ ID NO: 202

Table 2 Strains C. difficile wild type C. difficile strain Toxin B, SEQ ID NO: 2004013 SEQ ID NO: 110 2004111 SEQ ID NO: 111 2004118 SEQ ID NO: 112 2004205 SEQ ID NO: 113 2004206 SEQ ID NO: 114 2005022 SEQ ID NO: 115 2005088 SEQ ID NO: 116 2005283 SEQ ID NO: 117 2005325 SEQ ID NO: 118 2005359 SEQ ID NO: 119 2006017 SEQ ID NO: 120 2006376 SEQ ID NO: 121 2007070 SEQ ID NO: 122 2007217 SEQ ID NO: 123 2007302 SEQ ID NO: 124 2007816 SEQ ID NO: 125 2007838 SEQ ID NO: 126 2007858 SEQ ID NO: 127 2007886 SEQ ID NO: 128 2008222 SEQ ID NO: 129 2009078 SEQ ID NO: 130 2009087 SEQ ID NO: 131 2009141 SEQ ID NO: 132 2009292 SEQ ID NO: 133 001 SEQ ID NO: 158 002 SEQ ID NO: 159 003 SEQ ID NO: 160 012 (004) SEQ ID NO: 161 014 SEQ ID NO: 141 015 SEQ ID NO: 142 017 SEQ ID NO: 182 020 SEQ ID NO: 143 023 SEQ ID NO: 144 027 SEQ ID NO: 145 029 SEQ ID NO: 146 046 SEQ ID NO: 147 053 SEQ ID NO: 173 059 SEQ ID NO: 179 070 SEQ ID NO: 162 075 SEQ ID NO: 163 077 SEQ ID NO: 164 078 SEQ ID NO: 174 081 SEQ ID NO: 165 087 SEQ ID NO: 175 095 SEQ ID NO: 176 106 SEQ ID NO: 181 117 SEQ ID NO: 166 126 SEQ ID NO: 177 131 SEQ ID NO: 167

In another example of a chemically crosslinked mutant toxin, ie, a C. difficile polypeptide, at least one amino acid can be chemically crosslinked using a reagent that includes formaldehyde. Formaldehyde can react with the amino group of the N-terminal amino acid residue and the side chains of arginine, cysteine, histidine and lysine. Formaldehyde and glycine can form a Schiff base adduct that can add to primary N-terminal amino groups, arginine and tyrosine residues, and to a lesser extent to asparagine, glutamine, histidine, and tryptophan residues.

A chemical crosslinker is said to reduce the cytotoxicity of a toxin if the treated toxin has less toxicity (e.g., about 100%, 99%, 95%, 90%, 80%, 75%, 60%, 50%, 25%, or 10% less toxicity) than the untreated toxin under identical conditions when measured, for example, in an in vitro cytotoxicity assay, or in an animal toxicity assay.

Preferably, the chemical crosslinker reduces the cytotoxicity of the C. difficile mutant toxin by at least about 2-log ₁₀ reduction, more preferably about 3-log ₁₀ reduction, and most preferably about 4-log ₁₀ reduction, or more, compared to the mutant toxin under identical conditions but in the absence of a chemical crosslinker. The chemical crosslinker preferably reduces the cytotoxicity of the mutant toxin, compared to the wild-type toxin, by an amount corresponding to at least about 5-log ₁₀ reduction, about 6-log ₁₀ reduction, about 7-log ₁₀ reduction, about 8-log ₁₀ reduction , or more.

In another preferred embodiment, the chemically inactivated mutant toxin, i.e., polypeptide, of C. difficile has an EC ₅₀ value of greater than, or at least about, 50 μg/mL, 100 μg/mL, 200 μg/mL, 300 μg/mL . as the assay described in this paper.

The reaction conditions for reacting the mutant toxin with the chemical crosslinking agent are within the skill of those skilled in the art, and the conditions may vary depending on the reagent used. However, the inventors have determined the optimal reaction conditions for treating a mutant toxin, i.e., a polypeptide, with a C. difficile chemical crosslinker, while retaining functional epitopes and reducing the cytotoxicity of the mutant toxin compared to the corresponding wild-type toxin.

Preferably, for the treatment of the mutant toxin with a crosslinking agent, the reaction conditions are chosen so that the mutant toxin has a minimum concentration of about 0.5, 0.75, 1.0, 1.25, 1.5, 1.75, 2.0 mg / ml to a maximum of about 3.0, 2.5, 2.0, 1.5 or 1.25 mg/ml. Any minimum value can be combined with any maximum value to determine the range of concentrations of the mutant toxin suitable for the reaction. Most preferably, the mutant toxin has a reaction concentration of about 1.0-1.25 mg/mL.

In one embodiment, the reagent used in the reaction has a minimum concentration of about 1 mM, 2 mM, 3 mM, 4 mM, 5 mM, 10 mM, 15 mM, 20 mM, 30 mM, 40 mM, or 50 mM, and a maximum concentration of about 100 mM, 90 mM, 80 mM, 70 mM, 60 mM or 50 mM. Any minimum value can be combined with any maximum value to determine the range of suitable chemical reagent concentrations for the reaction.

In a preferred embodiment, when the reagent includes formaldehyde, the concentration used is preferably any concentration from about 2 mM to 80 mM, most preferably about 40 mM. In another preferred embodiment where the reagent includes EDC, the concentration used is preferably any concentration from about 1.3 mM to about 13 mM, more preferably from about 2 mM to 3 mM, most preferably about 2.6 mM. In one embodiment, the concentration of EDC is not more than 5 g/l, 4 g/l, 3 g/l, 2.5 g/l, 2 g/l, 1.5 g/l, 1.0 g/l, 0.5 g/l based on the total volume of the reaction mixture, preferably not more than 1 g/l, more preferably not more than 0.5 g/l.

Exemplary reaction times in which a mutant toxin is treated with a chemical crosslinker include a minimum of about 0.5, 1, 2, 3, 4, 5, 6, 12, 24, 36, 48, or 60 hours, and a maximum of about 14 days, 12 days, 10 days, 7 days, 5 days, 3 days, 2 days, 1 day, or 12 hours, 11, 10, 9, 8, 7, 6, 5, 4, 3, 2, or 1 hour. Any minimum value can be combined with any maximum value to determine a suitable response time range.

In a preferred embodiment, the step of treating the mutant toxin with a chemical crosslinker occurs for a period of time sufficient to reduce the cytotoxicity of the C. difficile mutant toxin to an EC ₅₀ value of at least about 1000 μg/mL in suitable human cells, e.g., IMR cells. -90, in a standard in vitro cytotoxicity assay, compared to an identical mutant toxin in the absence of a crosslinker. More preferably, the reaction step is carried out for a time period that is at least twice, and most preferably at least three times or more, the time period sufficient to reduce the cytotoxicity of the mutant toxin to an EC ₅₀ value. constituting at least about 1000 μg/ml in suitable human cells. In one embodiment, the reaction time does not exceed about 168 hours (or 7 days).

For example, in one embodiment in which the reagent includes formaldehyde, the mutant toxin is preferably treated with the reagent for about 12 hours, which is shown to be an illustrative period of time sufficient to reduce the cytotoxicity of the C. difficile mutant toxin to an EC ₅₀ value of at least about 1000 μg/ml in suitable human cells, eg, IMR-90 cells, in a standard in vitro cytotoxicity assay, compared to an identical mutant toxin in the absence of a crosslinker. In a more preferred embodiment, the reaction is carried out for about 48 hours, which is at least about three times the time period sufficient for the reaction. In such an embodiment, the reaction time preferably does not exceed about 72 hours.

In another embodiment, when the reagent includes an EDC, the mutant toxin is preferably treated with the reagent for about 0.5 hour, more preferably at least about 1 hour, or most preferably about 2 hours. In one embodiment, the mutant toxin is treated with EDC for no more than about 5 hours, preferably no more than about 3 hours, more preferably no more than about 2 hours. In such an embodiment, the reaction time preferably does not exceed about 6 hours.

Exemplary pH at which the mutant toxin is treated with a chemical crosslinker includes a minimum of about pH 5.5, 6.0, 6.5, 7.0, or 7.5 and a maximum of about pH 8.5, 8.0, 7 .5, 7.0 or 6.5. Any minimum value can be combined with any maximum value to determine a range of suitable pH values. Preferably, the reaction is carried out at pH 6.5-7.5, preferably at pH 7.0.

Exemplary temperatures at which the mutant toxin is treated with a chemical crosslinker include a minimum temperature of about 2°C, 4°C, 10°C, 20°C, 25°C, or 37°C, and a maximum temperature of about 40°C, 37°C. C, 30°C, 27°C, 25°C or 20°C. Any minimum value can be combined with any maximum value to determine a suitable reaction temperature range. Preferably, the reaction is carried out at about 20°C - 30°C, most preferably at about 25°C.

The immunogenic compositions described above may contain a single mutant toxin, ie, a polypeptide, C. difficile (A or B). Accordingly, the immunogenic compositions may be in separate vials (eg, a separate vial for a composition containing a mutant C. difficile toxin A and a separate vial for a composition containing a mutant C. difficile toxin B) in a formulation or kit. Immunogenic compositions may be designed for simultaneous, sequential or separate use.

In another embodiment, the immunogenic compositions described above may contain both mutant toxins, ie, polypeptide, C. difficile (A and B). Any combination of the described mutant C. difficile toxin A and mutant C. difficile toxin B can be used for the immunogenic composition. Accordingly, immunogenic compositions can be combined in a single vial (eg, a single vial containing both a composition containing a mutant C. difficile TcdA and a composition containing a mutant C. difficile TcdB). Preferably, the immunogenic compositions comprise mutant C. difficile TcdA and mutant TcdB, ie, C. difficile polypeptides.

For example, in one embodiment, the immunogenic composition comprises SEQ ID NO: 4 and SEQ ID NO: 6, wherein at least one amino acid in each of SEQ ID NO: 4 and SEQ ID NO: 6 is chemically crosslinked. In another embodiment, the immunogenic composition comprises a mutant C. difficile toxin A that contains SEQ ID NO: 4 or SEQ ID NO: 7, and a mutant C. difficile toxin B that contains SEQ ID NO: 6 or SEQ ID NO: 8, wherein at least one amino acid of each mutant C. difficile toxin is chemically crosslinked.

In another embodiment, the immunogenic composition comprises any sequence selected from SEQ ID NO: 4, SEQ ID NO: 84, and SEQ ID NO: 83, and any sequence selected from SEQ ID NO: 6, SEQ ID NO: 86, and SEQ ID NO: 85. In another embodiment, the immunogenic composition comprises SEQ ID NO: 84 and an immunogenic composition comprising SEQ ID NO: 86. In another embodiment, the immunogenic composition comprises SEQ ID NO: 83 and an immunogenic composition comprising SEQ ID NO: 85. In another embodiment, the immunogenic composition comprises SEQ ID NO: 84, SEQ ID NO: 83, SEQ ID NO: 86, and SEQ ID NO: 85.

In another embodiment, the immunogenic composition comprises a polypeptide having any sequence selected from SEQ ID NO: 1 - SEQ ID NO: 761 and a second polypeptide having any sequence selected from SEQ ID NO: 1 - SEQ ID NO: 761, with the polypeptide has been treated with a chemical crosslinker, such as, for example, formaldehyde or EDC, as described herein. For example, in one embodiment, the immunogenic composition comprises a first polypeptide having the amino acid sequence shown in any of SEQ ID NOs: 1-8, 15, 17, 19, 21, 23, 25, 28-35, 82-761, and a second a polypeptide having the amino acid sequence shown in any of SEQ ID NOs: 1-8, 15, 17, 19, 21, 23, 25, 28-35, 82-761, wherein the first polypeptide and the second polypeptide have been treated with a chemical crosslinker , such as, for example, formaldehyde or EDC, as described herein.

In specific embodiments, it is preferred that the compositions described herein exhibit immunogenic properties (eg, induce a detectable and/or neutralizing and/or protective immune response) upon appropriate administration to a subject. The presence of a neutralizing and/or protective immune response can be demonstrated as described above and/or by demonstrating that an infection caused by a pathogen (eg, C. difficile ) is affected (eg, reduced) in individuals (eg, humans or other animals) to which the materials described herein were introduced, in comparison with individuals who were not introduced to these materials. For example, one or more test subjects (e.g., human or non-human subjects) can be administered by any suitable route of administration and in any mode, the composition described herein, and then after an appropriate period of time (e.g., about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 weeks) challenge with the pathogen. Animal(s) can be monitored for immune function (eg, antibody production, T-cell activity) following administration and/or challenge. Sera can be assayed for overall antibody response or expression of specific subtypes using, for example, ELISA and/or pathogen neutralization assay. T-cell activity can be determined, for example, by measuring the production of IFN-γ after re-stimulation with antigen. Statistical analysis (eg, Fisher's exact test, Wilcoxon test, Mann-Whitney test) of the data can then be used to determine the effectiveness of the material influencing the immune response.

The C. difficile toxoids A and/or B described herein may be combined with one or more pharmaceutically acceptable carriers to form a composition prior to administration to a host. A pharmaceutically acceptable carrier is a material that is not biologically or otherwise undesirable, for example, the material can be administered to a subject without causing any undesirable biological effects or damaging interaction with any of the other components of the pharmaceutical composition in which it is contained. The carrier will naturally be chosen to minimize any degradation of the active ingredient and minimize any undesirable side effects in the subject, as will be known to those skilled in the art. Suitable pharmaceutical carriers and formulations thereof are described in, for example, Remington's: The Science and Practice of Pharmacy, 274' Edition, David B. Troy, ed., ^Lippicott Williams & Wilkins (2005) and may be appropriately selected. Typically, an appropriate amount of a pharmaceutically acceptable salt is used in the formulation to render the formulation isotonic. Examples of pharmaceutically acceptable carriers include, but are not limited to, sterile water, saline, buffer solutions such as Ringer's solution, and dextrose solution. The pH of the solution is typically from about 5 to about 8, or from about 7 to about 7.5. Other carriers include sustained release carriers such as semi-permeable matrices of solid hydrophobic polymers containing polypeptides or fragments thereof. The matrices may be in the form of shaped articles such as films, liposomes or microparticles. It will be apparent to those skilled in the art that certain carriers may be more preferred, depending on, for example, the route of administration and the concentration of the composition being administered. Carriers are carriers suitable for administration to humans or other subjects.

As stated above, the immunological composition is typically a composition containing C. difficile antigen(s) and, upon administration to a host (e.g., animal), induces or enhances an immune response directed against the antigen (e.g., C. difficile ) . Such responses may include antibody production (eg, through B cell stimulation) or a T cell response (eg, cytolytic response) as described above, which may be protective and/or neutralizing. A protective or neutralizing immune response may be a response that is detrimental to the infectious microorganism with the appropriate antigen (eg, from which the antigen was derived) and beneficial to the host (eg, by reducing or preventing infection). The protective or neutralizing antibodies and/or cellular responses described herein may be directed against the C. difficile antigen(s) described herein, especially when administered in an effective amount and/or regimen. Such antibodies and/or cellular responses may result in an attenuation or reduction in the severity, duration and/or lethality of C. difficile infection when tested in animals. As shown in the examples, the compositions described herein can be used to induce an immune response against C. difficile . An immunological composition that, when administered to a host, elicits a therapeutic (eg, typically when administered during an active infection) and/or protective (eg, typically when administered before or after an active infection) and/or neutralizing immune response can be considered vaccine.

In one embodiment, the composition induces an immune response. In a preferred embodiment, the use of the composition results in a reduction in the frequency of the first initial episode of C. difficile infection. The frequency may be reduced after the first administration of the composition, after the second administration of the composition, and/or after the third administration of the composition compared to the frequency before the first administration of the composition. In another embodiment, the use of the composition results in a reduction in the recurrence rate of C. difficile infection. The frequency of recurrence of infection can be reduced after the first administration of the composition, after the second administration of the composition and/or after the third administration of the composition.

In another embodiment, the use of the composition results in a reduction in the severity of the C. difficile infection. For example, the duration of an episode of C. difficile infection may be reduced after the first administration of the composition, after the second administration of the composition, and/or after the third administration of the composition compared to the frequency prior to the first administration of the composition. An episode of C. difficile infection may include, for example, at least two days with at least three loose stools and/or the need for an antibiotic to fight the C. difficile infection. The duration of an episode of C. difficile infection can be considered reduced if the patient does not have at least three or more loose stools for at least two days and/or no longer requires an antibiotic to fight the C. difficile .

In some embodiments, methods are also provided for preventing, alleviating, reducing the risk of developing and/or treating (eg, eliminating) a C. difficile infection. Methods for treating one or more disease states caused by, or involving, C. difficile in a subject include administering to the subject at least one or more effective doses of the compositions described herein (e.g., containing antigens, e.g., toxoid A, toxoid B , C. difficile ). The antigens can be administered in dose amounts from about 1 to about 300 μg (e.g., about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 30, 35, 40 , 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 1 10, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290 and/or 300 mcg). The antigens can be administered more than once in the same or different dose amounts. In specific embodiments, C. difficile antigens can be administered to a subject by the same or different suitable routes of administration one, two, three, four, five, six, seven, eight, nine, ten or more times. When multiple doses are administered, the doses may contain approximately the same or different types and/or amounts of C. difficile antigens in each dose. The doses may also be spaced in time at the same or different intervals. For example, doses may be separated by intervals of about 6, 12, 24, 36, 48, 60, 72, 84, or 96 hours, seven days, 14 days, 21 days, 30 days, 40 days, 50 days, 60 days, 70 days, 80 days, 90 days, 100 days, 110 days, 120 days, 130 days, 140 days, 150 days, 160 days, 170 days, 180 days, 190 days, 200 days, one week, two weeks, three weeks , one month, two months, three months, four months, five months, six months, seven months, eight months, nine months, 10 months, 11 months, 12 months, 1.5 years, 2 years, 3 years, 4 years , 5 years, or any period of time before, after and / or in between these periods of time. In some embodiments, C. difficile antigens can be administered alone or in combination with other reagents (eg, antibiotics). Such other reagents may be administered simultaneously (or approximately simultaneously) with the same or different C. difficile antigens, or at a different time and/or frequency. Other embodiments of such methods may also be suitable, as one of skill in the art can readily determine.

Also provided are methods of immunizing a subject (such as a human) by administering any such compositions. In some embodiments, the methods may include administering to the subject an immunogenic composition (e.g., a vaccine) containing an effective amount (e.g., at least about 40 to about 500, e.g., about 50 to about 100 µg) of toxoid A and toxoid B C. difficile (collectively, w/w) at an effective ratio of A:B toxoids (e.g., 3:1, 3:2, 1:1 by weight (w/w)) and with sufficient purity (e.g., at least 90% (w/w)), using one or more administrations (eg, at least three times, with appropriate separation of all doses over time (eg, at least about 7 days)). An effective ratio of toxoids A:B is any ratio in which they can be formulated to induce an effective immune response against C. difficile toxin A and/or toxin B.

In one embodiment, the method may include first, second, and third administrations, wherein the second administration is at least 7 days after the first administration, and the third administration is at least about 30 days and/or at least about 180 days after first and/or second administration.

In some embodiments, the methods may result in the induction and/or enhancement of an existing immune response in an individual previously exposed to C. difficile (eg, seropositive human, secondary immune response).

In one embodiment, the individual had an unplanned hospitalization within 12 months prior to the first administration of the composition. In another embodiment, the individual was in a skilled nursing facility (a nursing facility that provides vocational care and rehabilitation services, typically after being discharged from a hospital) within 12 months prior to first administration of the composition. In another embodiment, the individual has been in a nursing home (eg, a residential facility that provides professional care and rehabilitation services, typically after being discharged from a hospital) within 12 months prior to first administration of the composition. In another embodiment, the individual visited the emergency room two or more times within 12 months prior to the first administration of the composition. In another embodiment, the individual had 10 or more outpatient visits (visits for primary and/or secondary care, excluding visits to pharmacies and psychiatric services) within 12 months prior to first administration of the composition.

In another embodiment, the human was administered a systemic antibiotic within 12 weeks prior to the first administration of the composition. In another embodiment, the individual had significant comorbidity or health care exposure within 12 months prior to first administration of the composition. In another embodiment, the subject underwent 1 hospitalization in a hospital for ≥2 nights within 12 months prior to the first administration of the composition. In another embodiment, the subject visited the emergency room ≥2 times within 12 months prior to the first administration of the composition. In another embodiment, the individual had ≥10 outpatient visits within 12 months prior to the first administration of the composition. In another embodiment, the individual is in a skilled nursing facility within 12 months prior to the first administration of the composition. In another embodiment, the individual is in a nursing home within 12 months prior to the first administration of the composition. In another embodiment, the individual is scheduled for hospitalization for ≥2 nights ≥37 days after randomization within 12 months prior to first administration of the composition. In another embodiment, the individual has received systemic antibiotics at any time within the 12 weeks preceding the first administration of the composition.

In specific embodiments, the person works, or has contacts, in any of the following institutions within 12 months prior to the first administration of the composition: a hospital, a skilled nursing facility (a nursing facility that provides vocational care and rehabilitation services, typically , upon discharge from the hospital), nursing home (for example, a residential facility that provides professional care and rehabilitation services, usually after discharge from the hospital), emergency department and outpatient facility (visit for primary and/or secondary care, except for visits to pharmacies and mental health services).

In specific embodiments, the person(s) could, during the 12-month time period prior to the first administration, be in the hospital at least once or twice, each time for at least about 24, 48, or 72 hours, or more, and/or received systemic (non-topical) antibiotics; and/or, he will be hospitalized for a planned surgery within about 60 days after the first injection. In some embodiments, the expected/imminent hospital stay/hospitalization may be scheduled for about 24, 48-72 hours, or more, and the cause may be surgery involving at least one of: genitourinary system, musculoskeletal system, respiratory system , circulatory system and central nervous system.

Preferably, the immune response elicited by these methods is sufficient to prevent and/or alleviate and/or reduce the risk of symptomatic C. difficile infection. In specific embodiments, the method may include administering the immunogenic composition to a human subject at risk of developing a symptomatic infection that is at least about 40, 50, or 65, 70, 75, 80, or 85 years of age. In some embodiments, the implementation of the method may include the introduction of the composition to each individual in a group of people having an age of from about 40 to about 65 years, and/or from about 65 to about 75 years. In some embodiments, the method may result in about a two-fold to four-fold increase in immune response in the form of antibodies against C. difficile toxin A and/or B toxin B in about 80%, 85%, 90%, 95%, or 100% of a group of individuals considered seropositive up to the first injection, when measured, for example, in the analysis of ELISA and/or TNA. In some embodiments, the method may result in about a two to four-fold increase in immune response in the form of antibodies against C. difficile toxin A and/or toxin B in about 20%, 25%, 30%, 35%, 40%, 45%, or 50% of a population of individuals. , considered seronegative prior to composition administration, as measured, for example, in an ELISA and/or TNA assay 14 days after the first administration (eg, after administration on days 0, seven and 30). In some embodiments, the method may result in about a two- to four-fold increase in immune response in the form of antibodies against C. difficile toxin A and/or toxin B in about 30, 35, 40, 45, 50, 55, 60, 65, 70%, 75%, or 80% of a group of individuals considered seronegative prior to composition administration as measured, for example, in an ELISA and/or TNA assay 60 days after the first administration (eg, after administration on days 0, seven, and 30). In some embodiments, individuals in such groups are between about 40 and about 65 years of age. In some embodiments, individuals in such groups are between about 50 and 75 years of age, or between about 50 and about 65 years of age. In some embodiments, such an increase is observed about 30 days after the first administration (on day 0), typically followed by a second administration on about day 7, and is typically observed until the third administration (for example, on about day 30 or day 180). In some embodiments, an immune response against toxin A and/or toxin B can be detected up to about 30 months (eg, about 1000 days) after the first, second, and/or third administration in a multi-dose regimen. In some embodiments, administration of a composition described herein to a human subject on day 0 (first administration), about day 7 (second administration), and about day 30 (third administration) results in an enhancement or induction of an immune response against toxin A and/ or C. difficile toxin B for up to about 30 months, or about 1000 days, as measured, for example, in an ELISA and/or TNA assay, preferably in a cytotoxicity assay. In some embodiments, the level of immune response may be at least as high at about day 1000 after the first administration as at about day 14 after the first administration in a three-dose regimen, as measured, for example, in an ELISA and/or TNA assay. preferably in a cytotoxicity assay. In some embodiments, the level of immune response may be at least as high on about any of days 100, 200, 300, 400, 500, 600, 700, 800, 900, and 1000 after the first administration as on about day 14 after the first administration, when measured, for example, in an ELISA and/or TNA assay, preferably in a cytotoxicity assay. In some embodiments, the immune response may be about two to eight times baseline (e.g., levels of antibodies against toxin A and/or toxin B on day 0, prior to first administration, as measured, for example, in an ELISA and/or TNA assay. In some embodiments, the immune response may be from about 2.5 to about 6.8 times baseline, as measured, for example, in an ELISA and/or TNA assay, preferably in a cytotoxicity assay.In some embodiments, the immune response in seropositive individuals (e.g., previously exposed) about three times baseline on about day 7; about 10 to about 70 times on about day 14; about 30 to about 200 times on about day 30; and about 100 to about 200 times on about day 60, as measured in a toxin A and/or B ELISA assay (e.g., after administration on days 0, 7, and 30).In some embodiments, the immune response in seropositive and in individuals (eg, previously exposed) about three times baseline around day 7; about 10 to about 100 times on about day 14; about 15 to about 130 times on about day 30; and about 100 to about 130 times on about day 60, as measured in the TNA assay for toxins A and/or B (eg, after administration on days 0, seven, and 30). In some embodiments, the immune response in seronegative individuals (eg, naive) exceeds baseline by about two times around day 14; about five to about 10 times on about day 30; and about 25 to about 60 times about day 60, as measured in an ELISA for toxins A and/or B (eg, after administration on days 0, seven, and 30). In some embodiments, the immune response in seronegative individuals (eg, naive) exceeds baseline from about two to about three times around day 14; about two to about five times on about day 30; and about five to about 40 times on about day 60, as measured in the TNA analysis for toxins A and/or B (eg, after administration on days 0, 7, and 30). In some embodiments, the immune responses described herein are detected in individuals considered either seropositive or seronegative on day 0 (eg, prior to the first administration). In some embodiments, such an immune response is detected against both toxin A and toxin B, C. difficile when measured, for example, in an ELISA and/or TNA assay, preferably in a cytotoxicity assay. Also provided are methods (eg, in vitro or in vivo ) for producing such C. difficile antigens (eg, toxoids A and/or B) and compositions containing them. Such methods may include, for example, any of the methods available and/or known to those skilled in the art and/or the methods described in WIPO patent application WO/2012/143902, US patent No. 9187536 and WIPO patent application WO/2014/060898 , all of which are incorporated herein by reference in their entirety.

As used herein, "subject" or "host" means "individual". The term "subject" may include domestic animals such as cats and dogs, livestock (eg, cattle, horses, pigs, sheep, and goats), laboratory animals (eg, mice, rabbits, rats, guinea pigs), and birds. In one aspect, the subject is a mammal, such as a primate or a human.

Composition and vaccine

In one embodiment, the composition is an immunogenic composition. In one embodiment, the composition is a human immunogenic composition. In another embodiment, the composition is a vaccine. The term "vaccine" means a composition containing an antigen that contains at least one epitope that induces an immune response specific for that antigen. The vaccine can be administered directly to the subject by subcutaneous, oral, oronasal, or intranasal routes of administration. Preferably, the vaccine is administered intramuscularly. In one embodiment, the composition is a human vaccine. In one embodiment, the composition is an immunogenic composition against C. difficile .

In specific embodiments, the compositions may further comprise one or more C. difficile antigens, one or more pharmaceutically acceptable carriers, and/or one or more adjuvants (e.g., an aluminum salt, an emulsion, cationic liposomes, an anionic polymer, a Toll-like receptor agonist, and also their combination).

In one embodiment, the composition, which may be a vaccine, may be provided as a lyophilized preparation that can be reconstituted at the clinic with a diluent and mixed with any adjuvant (for example, an aluminum based adjuvant such as aluminum phosphate or aluminum hydroxide) or water for injection (WFI), as directed.

In one embodiment, the composition contains pharmaceutically acceptable carriers, which are any solvents, dispersion media, stabilizers, diluents and/or buffers that are physiologically acceptable. Exemplary stabilizers include carbohydrates such as sorbitol, mannitol, starch, dextran, sucrose, trehalose, lactose and/or glucose; inert proteins such as albumin and/or casein; and/or other large, slowly metabolized macromolecules, e.g., polysaccharides such as chitosan, polylactic acids, polyglycolic acids, and copolymers (e.g., SEPHAROSE™ functionalized latex, agarose, cellulose, etc.), amino acids, polymeric amino acids, amino acid copolymers, and lipid aggregates (such as oil drops or liposomes). In addition, these carriers can act as immunostimulatory agents (ie, adjuvants).

Preferably, the composition contains trehalose. Preferred amounts of trehalose (% by weight) include amounts from a minimum of about 1%, 2%, 3%, or 4% to a maximum of about 10%, 9%, 8%, 7%, 6%, or 5%. Any minimum value can be combined with any maximum value to determine a suitable range. In one embodiment, the composition contains about 3%-6% trehalose, most preferably 4.5% trehalose, for example, per 0.5 ml dose.

Examples of suitable diluents include distilled water, saline, physiological phosphate buffered saline, glycerol, alcohol (such as ethanol), Ringer's solutions, dextrose solution, Hank's balanced salt solutions, and/or lyophilization excipient. The diluent may be, for example, any pharmaceutically acceptable diluent (eg, 20 mM sodium citrate with 5% sucrose and 0.016% formaldehyde; 10 mM citrate with 4% sucrose, 0.008% formaldehyde, 0.57% sodium chloride). In a preferred embodiment, the composition contains 10 mM Tris, 4.5% trehalose, 0.01% polysorbate 80 (PS80), pH 7.4.

Exemplary buffers include phosphate (such as potassium phosphate, sodium phosphate); acetate (such as sodium acetate); succinate (such as sodium succinate); glycine; histidine; carbonate, tris (tris(hydroxymethyl)aminomethane) and/or bicarbonate (such as ammonium bicarbonate) buffers. Preferably, the composition contains a Tris buffer. Preferred amounts of Tris buffer include amounts from a minimum of about 1 mM, 5 mM, 6 mM, 7 mM, 8 mM, 9 mM, 10 mM to a maximum of about 100 mM, 50 mM, 20 mM, 19 mM, 18 mM, 17 mM , 16 mM, 15 mM, 14 mM, 13 mM, 12 mM or 11 mM. Any minimum value can be combined with any maximum value to determine a suitable range. In one embodiment, the composition contains about 8 mM - 12 mM Tris buffer, most preferably 10 mM Tris buffer, for example, per 0.5 ml dose.

In another preferred embodiment, the composition contains a histidine buffer. Preferred amounts of histidine buffer include amounts from a minimum of about 1 mM, 5 mM, 6 mM, 7 mM, 8 mM, 9 mM, 10 mM to a maximum of about 100 mM, 50 mM, 20 mM, 19 mM, 18 mM, 17 mM, 16 mM, 15 mM, 14 mM, 13 mM, 12 mM or 11 mM. Any minimum value can be combined with any maximum value to determine a suitable range. In one embodiment, the composition contains about 8 mM - 12 mM histidine buffer, most preferably 10 mM histidine buffer, for example, per 0.5 ml dose.

In another preferred embodiment, the composition contains a phosphate buffer. Preferred amounts of phosphate buffer include amounts from a minimum of about 1 mM, 5 mM, 6 mM, 7 mM, 8 mM, 9 mM, 10 mM to a maximum of about 100 mM, 50 mM, 20 mM, 19 mM, 18 mM, 17 mM, 16 mM, 15 mM, 14 mM, 13 mM, 12 mM or 11 mM. Any minimum value can be combined with any maximum value to determine a suitable range. In one embodiment, the composition contains about 8 mM - 12 mM phosphate buffer, most preferably 10 mM phosphate buffer, for example, per 0.5 ml dose.

The pH value of the buffer is generally chosen to stabilize the selected active material and can be determined by those skilled in the art using known methods. Preferably, the pH of the buffer will be in the physiological pH range. Thus, the preferred pH ranges are from about 3 to about 8; more preferably, from about 6.0 to about 8.0; even more preferably, from about 6.5 to about 7.5; and most preferably, from about 7.0 to about 7.2.

In another embodiment, the compositions described herein may contain the adjuvant described below. Preferred adjuvants enhance the characteristic immune response to the immunogen without inducing conformational changes in the immunogen that may affect the quality of the immune response. Illustrative adjuvants include 3-de-O-acylated monophosphoryl lipid A (MPL™) (see GB 2220211 (GSK)); an aluminum hydroxide gel such as ALHYDROGEL™ (Brenntag Biosector, Denmark); aluminum salts (such as aluminum hydroxide, aluminum phosphate, aluminum sulfate), which may be used with or without the addition of an immunostimulatory agent such as MPL or 3-DMP, QS-21, polymeric or monomeric amino acids such as polyglutamic acid or polylysine. Another exemplary adjuvant is an immunostimulatory oligonucleotide such as a CpG oligonucleotide (see e.g. WO 1998/040100, WO2010/067262) or a saponin and an immunostimulatory oligonucleotide such as a CpG oligonucleotide (see e.g. WO 00/062800). In a preferred embodiment, the adjuvant is a CpG oligonucleotide, most preferably CpG oligodeoxynucleotides (CpG ODNs). Preferred CpG ODNs are class B and preferentially activate B cells. In aspects of the invention, the CpG ODN has the nucleotide sequence 5' T*C*G*T*C*G*T*T*T*T*T*C*G*G*T*G*C*T*T*T* T 3' (SEQ ID NO: 48), where * denotes a phosphorothioate bond. A CpG ODN with this sequence is known as CpG 24555 described in WO2010/067262. In a preferred embodiment, CpG 24555 is used in conjunction with an aluminum hydroxide salt such as ALHYDROGEL. A further class of exemplary adjuvants includes saponin adjuvants such as STIMULON™ (QS-21, which is a triterpene glycoside or saponin, Aquila, Framingham, Mass.), or particles derived from it, such as ISCOM (Immunostimulatory Complexes), and an adjuvant ^ISCOMATRIX® . Accordingly, the compositions of the present invention can be delivered in the form of ISCOMs, ISCOMs containing CTBs, liposomes, or encapsulated compounds such as acrylates or poly(DL-lactide-co-glycoside) to form microspheres of a size suitable for absorption. Generally, the term "ISCOM" refers to immunogenic complexes formed between glycosides such as triterpenoid saponins (particularly Quil A) and antigens that contain a hydrophobic region. In a preferred embodiment, the adjuvant is an ISCOMATRIX adjuvant. Other illustrative adjuvants include RC-529, GM-CSF, complete Freund's adjuvant (CFA), and incomplete Freund's adjuvant (IFA). Another class of exemplary adjuvants are glycolipid analogs, including N-glycosylamides, N-glycosylureas, and N-glycosylcarbamates, each of which is substituted on the sugar moiety by an amino acid. Optionally, the pharmaceutical composition contains two or more different adjuvants. Preferred adjuvant combinations include any combination of adjuvants, including, for example, at least two of the following adjuvants: alum, MPL, QS-21, ISCOMATRIX, CpG, and ALHYDROGEL. An exemplary combination of adjuvants includes the combination of CpG and ALHYDROGEL.

The adjuvant may, for example, have an appropriate concentration (eg, about 800-1600 μg/ml) of an adjuvant, eg, an adjuvant containing an aluminum compound (eg, aluminum hydroxide or aluminum phosphate) in WFI. For example, an adjuvant (eg, 800-1600 g/ml aluminum hydroxide in 0.57% sodium chloride solution) can be used as a diluent to reconstitute the lyophilized formulation. WFI can be used to dilute a lyophilized vaccine for non-adjuvanted preparations. The final dosing solution may contain, for example, a composition/vaccine, a diluent and an adjuvant.

Alternatively, in one embodiment, the composition is administered to a mammal without an adjuvant. That is, the composition does not contain an adjuvant.

In some embodiments, the implementation of the composition contains a surfactant. Any surfactant is suitable, amphoteric, non-ionic, cationic or anionic. Exemplary surfactants include surfactants based on esters of sorbitan and fatty acids (for example, TWEEN ^® ), such as polysorbate 20 and/or polysorbate 80; polyoxyethylene fatty alcohol ethers of lauryl, cetyl, stearyl and oleyl alcohols (known as BRIJ surfactants), such as triethylene glycol monolauryl ether (BRIJ 30); TRITON X100, or t-octylphenoxypolyethoxyethanol; and esters of sorbitan (commonly known as SPAN), such as sorbitan trioleate (SPAN 85) and sorbitan monolaurate, as well as combinations thereof. Preferred surfactants include polysorbate 80 (polyoxyethylene sorbitan monooleate).

Polysorbate 80 (PS-80) is a non-ionic surfactant. In one embodiment, the composition contains PS-80 in the concentration range from 0.0005% to 1%. For example, the concentration of PS-80 in the composition may be at least 0.0005%, 0.005%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06% , 0.07%, 0.08%, 0.09%, 0.10%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7% , 0.8%, 0.9%, 1% or 1.1% PS-80. In one embodiment, the concentration of PS-80 in the composition may be no more than 2.0%, 1.9%, 1.8%, 1.7%, 1.6%, 1.5%, 1.4%, 1 .3%, 1.2%, 1.1%, 1.0%, 0.9%, 0.8% or 0.7% PS-80. Any minimum value can be combined with any maximum value described herein to define a range. Preferably, the composition contains 0.01% PS-80.

In an illustrative embodiment, the immunogenic composition comprises trehalose and polysorbate 80. In another illustrative embodiment, the immunogenic composition comprises Tris buffer and polysorbate 80. In another illustrative embodiment, the immunogenic composition comprises a histidine buffer and polysorbate 80. In another illustrative embodiment, the immunogenic composition comprises a phosphate buffer and polysorbate 80.

In one illustrative embodiment, the immunogenic composition comprises trehalose, Tris buffer, and polysorbate 80. In another illustrative embodiment, the immunogenic composition comprises trehalose, histidine buffer, and polysorbate 80. In another illustrative embodiment, the immunogenic composition comprises trehalose, phosphate buffer, and polysorbate 80.

In some embodiments, the pharmaceutical composition further comprises formaldehyde. For example, in a preferred embodiment, a pharmaceutical composition that further contains formaldehyde comprises an immunogenic composition wherein the mutant C. difficile toxin in the immunogenic composition has been treated with a chemical crosslinker that includes formaldehyde. The amount of formaldehyde present in the pharmaceutical composition can range from a minimum of about 0.001%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.010%, 0.013%, or 0.015%, to the maximum is approximately 0.020%, 0.019%, 0.018%, 0.017% 0.016%, 0.015%, 0.014%, 0.013%, 0.012% 0.011% or 0.010%. Any minimum value can be combined with any maximum value to determine a suitable range. In one embodiment, the pharmaceutical composition contains about 0.010% formaldehyde.

In some alternative embodiments, the pharmaceutical compositions described herein do not contain formaldehyde. For example, in a preferred embodiment, a pharmaceutical composition that does not contain formaldehyde comprises an immunogenic composition wherein at least one amino acid of the mutant C. difficile toxin is chemically crosslinked with a reagent that includes EDC. More preferably, in such an embodiment, the mutant C. difficile toxin has not been treated with a chemical crosslinker that includes formaldehyde. In another illustrative embodiment, the pharmaceutical composition, which is in lyophilized form, does not contain formaldehyde.

Also provided herein are kits for the administration of C. difficile antigens. In one embodiment, one or more C. difficile antigens may be part of, and/or provided as a kit for administration to a subject. The kit may also provide instructions for administering C. difficile antigens. Compositions containing C. difficile antigens described herein may be included in a kit (eg, vaccine kit). For example, the kit may include a first container containing the composition described herein in dry or lyophilized form, and a second container containing an aqueous solution to reconstitute the composition. The kit may optionally include a device for administering the reconstituted composition in liquid form (eg, hypodermic syringe, microneedle set) and/or instructions for use. The administration device may be provided with a pre-filled aqueous solution to reconstitute the composition.

The volume of each delivered dose of investigational medicinal product (vaccine or placebo) may be approximately 0.5 ml. The volume of each delivered dose of the composition disclosed herein may be about 0.2, 0.3, 0.4, 0.5, 0.6, 0.7; 0.8, 0.9 or 1 ml. The volume of each delivered dose of the composition disclosed herein may be about 0.4, 0.5, 0.6 ml. The volume of each delivered dose of the composition disclosed herein may be about 0.5 ml. The volume of each delivered dose of the composition disclosed herein may be about 1 ml. The formulations may be administered by any suitable route of administration (eg, subcutaneous, intravenous, intramuscular, intraperitoneal, intradermal, lymph node, intranasal, oral).

Detoxifying activity

The immune response induced by administration of the composition to a human can be determined using a toxin neutralization assay (TNA), ELISA, or more preferably a cytotoxicity assay, e.g. WO/2014/060898, all of which are incorporated herein by reference in their entirety.

The in vitro cytotoxicity assay is a key safety assay designed to test for any potential residual cytotoxicity in a drug substance material. Determination of any potential residual cytotoxicity of toxoid A is performed using an IMR-90 cell-based assay. C. difficile wild-type toxin A exhibits strong in vitro cytotoxicity, with small amounts of the toxin being sufficient to cause various effects in mammalian cells, such as cell rounding (cytopathic effect or CPE) and lack of metabolic activity (as determined by ATP levels) . The CPE assay is performed by incubating with IMR90 cells in a culture of toxoid material at 500 μg/ml at 37° C. and evaluating cell rounding after 24 hours. CPE analysis requires subjective visual assessment of CPE by specially trained analysts and thus cannot be readily validated. A cytotoxicity assay was developed based on the measurement of the intensity of the luminescent signal generated from ATP, which is proportional to the number of metabolically active cells after treatment with either toxoid A or wild-type toxin. The results are expressed as EC ₅₀ , which is defined as the amount of toxin or toxoid that causes a 50% decrease in ATP levels, measured as relative light units. The toxoid is tested at a concentration of 100 μg/ml. This method was chosen for release and stability testing (limited number of time points) because it is more reliable, objective and suitable for GMP testing than alternative cytopathic effect (CPE) assay. Cytotoxicity analysis is performed on the toxoid only, since it can be tested at a higher concentration than the drug product material without interference from the matrix. This ensures that the measurement is taken at the highest concentration step in the C. difficile vaccine manufacturing cycle. In addition, the cytotoxicity assay will be performed stably to monitor for any potential recovery of toxicity.

The in vitro cytotoxicity assay is a key safety assay designed to test for any potential residual cytotoxicity in a drug substance material. Determination of any potential residual cytotoxicity of toxoid B is performed using an IMR-90 cell-based assay. C. difficile wild-type toxin B exhibits strong in vitro cytotoxicity, with small amounts of the toxin being sufficient to cause various effects in mammalian cells, such as cell rounding (cytopathic effect or CPE) and lack of metabolic activity (as determined by ATP levels) . The CPE assay is performed by incubating with IMR90 cells in a culture of toxoid material at 500 μg/ml at 37° C. and evaluating cell rounding after 24 hours. CPE analysis requires subjective visual assessment of CPE by specially trained analysts and thus cannot be readily validated. A cytotoxicity assay was developed based on measuring the intensity of the luminescent signal generated from ATP, which is proportional to the number of metabolically active cells after treatment with either toxoid B or wild type B toxin. The results are expressed as EC ₅₀ , which is defined as the amount of toxin or toxoid that causes a 50% decrease in ATP levels, measured as relative light units. The maximum toxoid concentration that was initially tested in this assay was 200 µg/mL. However, the results of using the method over time indicated that a maximum concentration of only 100 μg/ml could lead to reliable performance. This method was chosen for release and stability testing (limited number of time points) because it is more reliable, objective, and suitable for GMP testing than the alternative CPE assay. Cytotoxicity analysis is only performed on toxoid B drug substance material, as it can be tested at a higher concentration than the drug product material without interference from the matrix. This ensures that the measurement is taken at the highest concentration step in the C. difficile vaccine manufacturing cycle. In addition, the cytotoxicity assay will be performed stably to monitor for any potential recovery of toxicity.

To validate the suitability of the 50% neutralization titer assay for clinical use, to provide additional reliability of the assay, and to ensure uniform long-term functional parameters in the clinical setting, a reference standard and appropriate controls were added to the assay, allowing neutralization titer results to be obtained in units of neutralization/mL relative to the reference standard. . Prior to analysis, the current study used sera from vaccinated individuals to demonstrate a linear relationship between 50% neutralization titers and units of neutralization/mL in the neutralization assay. From these correlation studies, "defensive" neutralization thresholds were calculated and used to analyze the clinical data in this study.

In one embodiment, TNA is an automated and sensitive assay based on luminescence indices. The neutralization titers of the test samples are calculated from the reference standard. In one embodiment, the LEL of the assay for Txd A is 158.0 U/mL; for Txd B=249.5 U/ml. Preferably TNA

In the immunogenicity assays, cut-offs for "protective" responses in the form of producing neutralizing antibodies against toxin A and toxin B were 219 and 2586 neu/mL, respectively. Several immunogenicity endpoints for Study B5091009 were evaluated based on these protective response thresholds.

As used herein, unless specifically stated otherwise, the "assigned threshold" value is defined as 219 neu/ml for toxin A and 2586 neu/ml for toxin B.

In one embodiment, the immune response induced in the human is neutralizing against the strainC. difficile, which expresses toxin A having an amino acid sequence that has at least 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identity with the toxoid A sequence of the composition.

In another embodiment, the immune response induced in the human is neutralizing against the strainC. difficile, which expresses toxin B having an amino acid sequence that has at least 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identity with the toxoid B sequence of the composition.

The usefulness (eg, immunogenicity) of any of the materials (eg, compositions) and/or methods described herein can be assessed by any of a variety of methods known to those skilled in the art. Any one or more of the assays described herein, or any other one or more suitable assays, can be used to determine the suitability of any of the materials described herein for the intended purpose. It should be understood that these methods are illustrative and non-limiting; other assays may also be suitable. For example, the compositions described herein typically induce and/or enhance the production of antibodies against C. difficile when administered to a subject. Such antibodies can be detected in a subject using any of the methods available to those skilled in the art. For example, as described in the Examples section, sera can be obtained from a subject and tested by ELISA to detect antibodies - immunoglobulin type G (IgG) to C. difficile toxin A and/or toxin B (e.g., "primary immunogenicity data" ). Antibodies present in the test serum may react with antigens, toxins A or B, adsorbed in individual wells of the microtiter plate. The amount of antibodies bound to the antigen coated on the wells can be determined using a colorimetric reaction with the substrate after binding of an enzyme-conjugated secondary anti-IgG antibody (eg, anti-human IgG). Then, as a rule, an enzyme substrate is added, causing a color change in the reaction mixture, in direct proportion to the amount of antibodies associated with the antigen. Serum antibody concentration can be determined by extrapolation from a standard curve that has been constructed using several dilutions of a reference serum standard with a known number of IgG units (ELISA units (EU)/mL)). A toxin neutralization assay (TNA) can also be used to quantify neutralizing antibodies to C. difficile toxin. In this assay, serially diluted serum can be incubated with a fixed amount of C. difficile toxin A or B. Cells to be tested (eg Vero cells) can then be added and the serum-toxin-cell mixture incubated under appropriate conditions (eg at 37° C. for 6 days). The ability of serum to neutralize the cytotoxic effect of C. difficile toxin can be determined based on and correlates with cell viability. The assay uses the accumulation of acid metabolites in closed culture wells as an indicator of normal cellular respiration. In cells exposed to the toxin, metabolism and CO ₂ production are reduced; therefore, the pH value increases (eg to 7.4 or higher) as indicated by the pH indicator phenol red in the cell culture medium. At this pH value, the medium looks red. However, control cells, or cells exposed to a toxin that has been neutralized by an antibody, have normal metabolism and CO ₂ production; as a result, the pH value is maintained at a normal level (for example, 7.0 or lower), and at this pH value, the medium appears yellow. Thus, the amount of antibodies that neutralize C. difficile toxin correlates with the ability of serum to neutralize the metabolic effects of C. difficile toxin on cells, as indicated by their ability to maintain a certain pH value (eg, 7.0 or below). The color change of the medium can be measured (eg, at a wavelength of 562 nm to 630 nm) using a plate reader to then calculate the toxin-neutralizing antibody titer at 50% inhibition of C. difficile toxin-mediated cytotoxicity. In one embodiment, the composition induces the production of a toxin-neutralizing antibody with a titer that is at least 1-fold higher, such as at least 1.01-fold, 1.1-fold, 1.5-fold, 2-fold, 3-fold, 4-fold. times, 5 times, 6 times, 7 times, 8 times, 9 times, 10 times, 11 times, 12 times, 13 times, 14 times, 15 times, 16 times, 32 times, or more, in a human after receiving a dose of the composition than the toxin-neutralizing antibody titer in humans prior to the indicated dose, when measured under identical conditions in the toxin neutralization assay.

Credits

In one embodiment, the composition induces an increase in a toxin-neutralizing antibody titer in a human relative to a toxin-neutralizing antibody titer in a human prior to administration of a dose of the composition, when measured under identical conditions, eg, in a cytotoxicity assay. In one embodiment, the increased toxin-neutralizing antibody titer is compared to the toxin-neutralizing antibody titer in a human prior to administration of the first dose of the composition, i.e., compared to the toxin-neutralizing antibody titer in a human prior to administration of the first dose of the composition, when measured under identical conditions, e.g., in an assay cytotoxicity. In another embodiment, an increase in titer is observed after the second dose of the composition compared to the titer of the toxin-neutralizing antibody in humans prior to the first dose of the composition, when measured under identical conditions, eg, in a cytotoxicity assay. In another embodiment, an increase in toxin-neutralizing antibody titer is observed after the third dose of the composition compared to the human toxin-neutralizing antibody titer prior to administration of the first dose of the composition, when measured under identical conditions, e.g., in a cytotoxicity assay. In another embodiment, an increase in titer is observed after the second dose of the composition compared to the titer of the toxin-neutralizing antibody in humans prior to the second dose of the composition, when measured under identical conditions, eg, in a cytotoxicity assay. In another embodiment, an increase in toxin-neutralizing antibody titer is observed after the third dose of composition compared to human toxin-neutralizing antibody titer prior to administration of the third dose of composition, when measured under identical conditions, eg, in a cytotoxicity assay.

In one embodiment, the composition induces a toxin-neutralizing antibody titer in a post-dose human, wherein the toxin-neutralizing antibody titer is at least more than 1-fold higher than the toxin-neutralizing antibody titer in the pre-dose human, when measured under identical conditions, e.g. , in a cytotoxicity assay. For example, the toxin neutralizing antibody titer can be at least 1.01 times, 1.1 times, 1.5 times, 2 times, 3 times, 4 times, 5 times, 6 times, 7 times, 8 times, 9 times , 10-fold, 11-fold, 12-fold, 13-fold, 14-fold, 15-fold, 16-fold, 32-fold, or 64-fold higher in a post-dose human compared to the pre-dose human toxin-neutralizing antibody titer, as measured in identical conditions, for example, in the analysis of cytotoxicity.

In one embodiment, the term "responder" refers to a human in which the composition induces a toxin-neutralizing antibody titer after dosing, wherein the toxin-neutralizing antibody titer is at least more than 1-fold higher than the toxin-neutralizing antibody titer in the human prior to dose administration. In a preferred embodiment, the responsive human exhibits an increase of at least ≥4-fold in toxin-neutralizing antibody titer compared to the pre-dose human toxin-neutralizing antibody titer. It can be said that such a responding person has a protective antibody titer.

In one embodiment, the composition induces a toxin-neutralizing antibody titer in a human after receiving the first dose that is at least 2-fold higher than the toxin-neutralizing antibody titer in the human prior to the first dose (e.g., higher than the toxin-neutralizing antibody titer in a human in no first dose), when measured under identical conditions in the cytotoxicity assay. In one embodiment, the composition induces a toxin-neutralizing antibody titer in a human that is at least 4-fold higher than the toxin-neutralizing antibody titer in a human prior to the first dose, when measured under identical conditions in a cytotoxicity assay. In one embodiment, the composition induces a toxin-neutralizing antibody titer in a human that is at least 8-fold higher than the toxin-neutralizing antibody titer in a human prior to the first dose, when measured under identical conditions in a cytotoxicity assay.

In one embodiment, the human has, for example, a toxin-neutralizing antibody titer equal to or greater than the lower limit of quantification (LQQ) in a cytotoxicity assay after administration of the first dose of the composition. In another embodiment, the human has, for example, in a cytotoxicity assay, a titer equal to or greater than the LEL in the cytotoxicity assay after administration of a second dose of the composition. In another embodiment, the human has, for example, a toxin-neutralizing antibody titer equal to or greater than the LEL in the cytotoxicity assay after administration of the third dose of the composition.

Methods and Introduction

In one aspect, the invention relates to a method for inducing an immune response against C. difficile in a human. In another aspect, the invention relates to a method for vaccinating a human. In one embodiment, the method includes administering to a human at least one dose of the composition described above. In a preferred embodiment, the method comprises administering to a human no more than one dose of the composition described above. In another embodiment, the method includes administering to a human at least a first dose and a second dose of the composition described above.

In one embodiment, the second dose is administered at least 20, 30, 50, 60, 100, 120, 160, 170, or 180 days after the first dose, and no more than 250, 210, 200, or 190 days after the first dose. Any minimum value can be combined with any maximum value described herein to define a range.

In another embodiment, the second dose is administered about 30 days after the first dose. In another embodiment, the second dose is administered about 60 days after the first dose, such as the 0.2 month immunization schedule. In another embodiment, the second dose is administered about 180 days after the first dose, such as the 0.6 month immunization schedule. In another embodiment, the second dose is administered about 120 days after the first dose, such as the immunization schedule at 2.6 months.

In one embodiment, the method includes administering to a human two doses of the composition, and no more than two doses. In one embodiment, two doses are administered within a time period of about 6 months after the first dose. In one embodiment, the method does not include an additional booster dose to a human. As used herein, the term "booster" means additional administration of the composition to a human. Administration to a human of no more than two doses of the composition may be advantageous. Such advantages include, for example, easier adherence by a person to a complete administration regimen and reduced cost of administration of the regimen.

In one embodiment, the first dose and the second dose are administered to a human over a period of about 5 days, 7 days, 14 days, 21, 25, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130 , 140, 150, 160, 170, 180, 190 or 200 days, and no more than 400, 390, 380, 370, 365, 350, 340, 330, 320, 310, 300, 290, 280, 270, 260, 250 , 240, 230, 220, 210 or 200 days after the first dose. In one embodiment, the second dose is administered to the human at least 8, 14, 21, 25, or 30 days, and no more than 100, 90, 80, 70, 60, 50, 45, 40, 35, or 30 days after administration. first dose. For example, in one embodiment, the second dose is administered to the human at least 21 days and not more than 40 days after the first dose. Any minimum value can be combined with any maximum value described herein to define a range. Preferably, the first dose and the second dose are administered to a human over a period of about 8 days. More preferably, the first dose and the second dose are administered to a human over a period of about 30 days. Most preferably, the first dose and the second dose are administered to a human over a period of at least about 30 days.

In one embodiment, the first dose and the second dose are administered to a human over a period of about 30 days. In another embodiment, the first dose and the second dose are administered to a human over a period of about 60 days. In another embodiment, the first dose and the second dose are administered to a human over a period of about 180 days.

In one embodiment, the first dose and the second dose are administered to a human over a period of no more than 30 days. In another embodiment, the first dose and the second dose are administered to a human over a period of no more than 60 days. In another embodiment, the first dose and the second dose are administered to a human over a time period of no more than 180 days.

Doses

In one embodiment, the method includes administering three doses of the composition to a human. In another embodiment, the method includes administering no more than three doses of the composition. In one embodiment, three doses are administered over a period of about 6 months after the first dose. In one embodiment, the method includes administering a booster dose to a human after the third dose. In another embodiment, the method does not include administering a booster dose to a human after the third dose. In another embodiment, the method does not include additional administration of a fourth or booster dose of the composition to a human. In a further embodiment, no more than three doses are administered to a human within a time period of about 6 months.

In an exemplary embodiment, the second dose is administered about 30 days after the first dose, and the third dose is administered about 150-180 days after the second dose, eg, in a 0, 1, 6 month immunization schedule. In another illustrative embodiment, the second dose is administered about 60 days after the first dose, and the third dose is administered about 120 days after the second dose, eg, in a 0, 2, 6 month immunization schedule.

In one embodiment, the first dose, second dose, and third dose are administered to a human over a period of about 150, 160, 170, or 180 days, and no more than 240, 210,200, or 190 days. Any minimum value can be combined with any maximum value described herein to define a range. Preferably, the first dose, second dose, and third dose are administered to a human over a period of about 180 days or 6 months. For example, a second dose may be administered to a human about 60 days after the first dose, and a third dose may be administered to a human about 120 days after the second dose. Accordingly, an exemplary administration schedule includes administering a dose to a human at about months 0, 2, and 6.

As described above, multiple doses of the immunogenic composition may be administered to a human, and the number of days between each dose may vary. The advantage of the method includes, for example, the flexibility to facilitate human compliance with administration regimens.

In one embodiment, the method includes administering to a human no more than three doses of the same immunogenic composition. For example, in a preferred embodiment, the method does not include administering a first dose of a first composition to a human, administering a second dose of a second composition to a human, and administering a third dose of a third composition to a human, wherein the first, second, and third compositions are not identical. In another embodiment, the method comprises administering to a human no more than four doses of the same immunogenic composition.

EXAMPLES

The following examples illustrate embodiments of the invention. Unless otherwise indicated herein, the following examples refer to a candidate vaccine or immunogenic composition containing a mixture of genetically modified toxoid A, i.e., a polypeptide, C. difficile (comprising SEQ ID NO: 4, in which the initial methionine residue missing) and a genetically modified toxoid B, i.e., a polypeptide, C. difficile (containing SEQ ID NO: 6, in which the initial methionine residue is missing), which were further chemically inactivated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide) (EDC) and N-hydroxysuccinimide (NHS) to eliminate residual cytotoxicity but retain the natural antigenic structure and induce a neutralizing antibody response as described in Example 21 in WIPO patent application WO/2012/143902, patent US No. 9187536 and WIPO Patent Application WO/2014/060898, WIPO Patent Application WO/2012/143902, US Patent No. 9187536 and WIPO Patent Application WO/2014/060898, all of which are incorporated herein by reference in their entirety. Briefly, after purification, GM toxins (SEQ ID NO: 4 and SEQ ID NO: 6) are inactivated for 2 hours at 25° C. using 0.5 mg EDC and 0.5 mg NHS per mg purified GM toxins A and B (about 2.6 mm and 4.4 mm, respectively). The reaction is quenched by adding glycine to a final concentration of 100 mm, and the reaction mixture is incubated for an additional 2 hours at 25°C. Inactivation is carried out at pH 7.0 ± 0.5 in 10 mM phosphate buffer, 150 mM sodium chloride. The inactivation period should be three times the period required to reduce the EC ₅₀ value in IMR90 cells by more than 1000 μg/ml. After 2 hours, the biological activity is reduced by 7-8 log ₁₀ relative to the natural toxin. After 4 hours of incubation, the inactivated mutant toxin is transferred to the final drug substance buffer by diafiltration. For example, using a regenerated cellulose acetate ultrafiltration cassette with a cutoff of 100 kDa, the inactivated toxin is concentrated to a concentration of 1-2 mg/ml and a buffer exchange is carried out. More specifically, the vaccine composition contains: (a) a first polypeptide that has the amino acid sequence shown in SEQ ID NO: 4, while the methionine residue at position 1 in SEQ ID NO: 4 is absent, while the side chain of the lysine residue of the first polypeptide is cross-linked with a beta-alanine fragment, and wherein the first polypeptide further has a crosslink between the side chain of the aspartic acid residue of the first polypeptide and a glycine fragment, and a crosslink between the side chain of the glutamic acid residue of the first polypeptide and the glycine fragment; and (b) a second polypeptide that has the amino acid sequence shown in SEQ ID NO: 6, wherein the methionine residue at position 1 in SEQ ID NO: 6 is absent, while the side chain of the lysine residue of the second polypeptide is linked to a beta-alanine fragment, and wherein the second polypeptide further has a crosslink between the side chain of the aspartic acid residue of the second polypeptide and the glycine moiety, and a crosslink between the side chain of the glutamic acid residue of the second polypeptide and the glycine moiety.

The C. difficile vaccine under investigation consists of 2 toxoids (A and B) in equal amounts. The vaccine was provided as a sterile lyophilized powder at a dosage of 100 µg and 200 µg of total toxoids A and B per dose. The vaccine was prepared for injection by resuspension of the lyophilized vaccine in aluminum hydroxide diluent just prior to use. The diluent, aluminum hydroxide, was provided as a liquid suspension containing 1 mg aluminum/ml (in the form of aluminum hydroxide).

In preclinical experiments, the vaccine candidate has been studied either alone or in combination with an adjuvant. In a hamster model, all vaccine formulations have demonstrated survival utility, providing at least 90% protection against lethal C. difficile spore challenge in immunized hamsters. In the primate model, all toxoid vaccine formulations tested induced robust neutralizing antibody responses against the toxin, both C. difficile toxin A and C. difficile toxin B.

Example 1 - First Phase 1 Human Study, 3 Dose Schedule at Months 0, 1 and 6 (B5091001)

An exemplary vaccine candidate against C. difficile was evaluated in the first phase 1 human study (FIH) B5091001, conducted in the USA, which included 192 healthy adults aged 50 to 85 years. This was a dose-escalation, placebo-controlled, randomized, observer-blinded trial to evaluate the safety, tolerability, and immunogenicity of C. difficile vaccine at 3 doses at months 0, 1, and 6. Three (3) levels were assessed. doses of antigens (50, 100 and 200 µg) of the candidate vaccine, either alone or in combination with aluminum hydroxide.

Safety analyzes showed that both drugs and all 3 dose levels were generally well tolerated. Local reactions were predominantly mild to moderate, and were mainly pain at the injection site. No truly severe or grade 4 local reactions were noted. In the 65-85 age group, at the 200 µg dose level, local reactions tended to occur more frequently in the toxoid-only group compared to the aluminum hydroxide dose groups. After all 3 doses, the frequency and severity of local reactions did not increase with increasing dose level or number of doses in the all dose groups. Systemic events were predominantly mild to moderate and were mainly headache and fatigue. There was no evidence of an increase in the frequency of systemic events with increasing dose level or number of doses in the all dose groups.

Immunogenicity analysis showed a limited antibody response after dose 1, however, after dose 2 there was a significant increase in antibody titers against both toxin A and toxin B, which were generally maximal at 7 days after dose 2, and stable after 1 month after dose 2. Seven (7) days after dose 3, a significant booster response was evident, which was slightly more pronounced again 1 month after dose 3. Overall, strong anti-toxin neutralizing antibody responses were produced by both drugs, although there was a trend in the form of stronger responses in recipients of the drug with only toxoids. For example, at 1 month after dose 3 in the 65-85 year age group, the geometric mean fold increase (GMEF) from baseline (up to dose 1) of toxin A-specific neutralizing antibody titers ranged from 131 to 254 in the s-only dose groups. toxoids and 42 to 80 in the aluminum hydroxide dose groups. The corresponding ranges for toxin B-specific neutralizing antibody titers were 2953 to 4922 and 136 to 484, respectively.

Preclinical data in rhesus monkeys support the use of a 3-dose C. difficile vaccine schedule administered with or without addition of aluminum hydroxide at weeks 0, 2, and 4. In addition, in a toxicology study in rabbits, the regimen 4 doses of C. difficile vaccine (dose levels up to 400 µg) given on days 1, 8, 22, and 36 did not result in adverse toxicological results and caused an increase in neutralizing antibody titers against toxin A and against toxin B, confirming the expected immunological response in animals to the administered immunogen.

These preclinical and toxicological data, as well as the encouraging immune response observed after 3 doses in the phase 1 study B5091001, were in support of the phase 2 study B5091003.

Example 2 Phase 2 Study, 3 Dose Schedule on Days 1, 8 and 30 (B5091003)

Phase 2 study B5091003 was designed to evaluate the safety, tolerability, and immunogenicity of the toxoid-only vaccine.C. difficile, at dose levels of 100 and 200 µg of antigen (toxoids A and B total) in a 3-dose regimen given on days 1, 8, and 30 in healthy adults aged 50 to 85 years.

Vaccinations in study B5091003 were stopped after the appearance of redness at the injection site. The subjects had no associated severe systemic symptoms, no redness was noted to interfere with their daily activities, and all local reactions resolved completely. Local reactions observed in the case of a preparation containing only toxoids could be due to the interaction of free toxoids and the immune response elicited.

Example 3 Phase 2 Study, 3 Dose Schedule on Days 1, 8, and 30 (Daily Schedule) or Months 0, 1, and 6 (Monthly Schedule) (B5091009)

It has been shown that adsorption on aluminum leads to binding and slow release of vaccine components from the injection zone. In addition, there is a potential need for rapid induction of an immune response and prolonged protection against CDI. Accordingly, study B5091009 assessed the safety, tolerability, and immunogenicity of an aluminum hydroxide-containing vaccine at 2 dose levels of antigens (i.e., total of 100 µg and 200 µg of toxoids) selected from FIH study B5091001 using 2 different dosing regimens: on days 1, 8 and 30 or in months 0, 1 and 6.

The primary endpoint of immunogenicity was assessed based on the ability of the vaccine to induce levels of toxin A specific and toxin B specific neutralizing antibodies greater than or equal to the established thresholds for each C. difficile toxoid in the vaccine. These established thresholds were taken from a phase 2 efficacy study showing that passive administration of 2 mAb against toxin A and toxin B resulted in protection against CDI. In addition to the demonstrated efficacy of anti-toxin mAbs against recurrent CDI infection, results from the phase 2 efficacy study also indicated that levels of neutralizing anti-toxin A and anti-toxin B mAbs above the cut-off of 10 µg/mL (the "protective" threshold) associated with protection against recurrence of CDI infection.

The observation that (1) the same cytotoxicity assay was used to translate the "protective" toxin A and toxin B threshold levels from the Phase 2 Efficacy Evaluation study into 50% neutralization titers induced by the candidate vaccine was used. to measure the neutralization of toxins and (2) the inhibitory mAb concentration that results in the neutralization of 50% of the toxins (IC_fifty [50% inhibitory concentration]) has been published (IC values_fifty for mAbs against toxin A and toxin B are 100 ng/ml and 15 ng/ml, respectively). The "protective" titer of 50% neutralization for each antibody against the toxin was thus calculated as the antibody concentration at a protective cutoff level of 10 μg/mL divided by the IC value_fifty corresponding mat.

To validate the suitability of the 50% neutralization titer assay for clinical use, to provide additional reliability of the assay, and to ensure uniform long-term functional parameters in the clinical setting, a reference standard and appropriate controls were added to the assay, allowing neutralization titer results to be obtained in units of neutralization/mL relative to the reference standard. . Prior to analysis, the current study used sera from vaccinated individuals to demonstrate a linear relationship between 50% neutralization titers and units of neutralization/mL in the neutralization assay. From these correlation studies, "defensive" neutralization thresholds were calculated and used to analyze the clinical data in this study.

In the immunogenicity assays, the "protective" thresholds for neutralizing antibody responses against toxin A and toxin B were 219 and 2586 neu/mL, respectively. Several immunogenicity endpoints for Study B5091009 were evaluated based on these protective response thresholds.

As used herein, unless specifically stated otherwise, the "assigned threshold" value is defined as 219 neu/ml for toxin A and 2586 neu/ml for toxin B.

Because it will be important to provide vaccinated subjects with prolonged protection against CDI, and because individuals who require vaccination may have a reduced ability to generate and maintain an immune response, the subjects in the present study were monitored after their third vaccination to assess antibody persistence and response to the fourth vaccination. Thus, subjects on both dosing regimens who received the first 3 doses of C. difficile vaccine (100 µg or 200 µg) were offered an extension phase and were randomized 1:1 to receive C. difficile vaccine. or placebo. These subjects will receive either a fourth dose of C. difficile vaccine at the same antigen dose level (100 µg or 200 µg) they previously received, or placebo, approximately 1 year after their third dose. These subjects will be observed to assess the persistence of antibodies. Subjects initially randomized to placebo on any dosing regimen will not participate in the extended phase of the study.

Analyzes in this clinical study were performed when all subjects completed visit 9 (month 13 for subjects on days 1, 8, and 30 [daily schedule] and month 18 for subjects on months 0, 1, and 6 [mode of administration by month]), and all immunogenicity and safety data up to and including visit 9 were available.

Analysis methods. Any level of C. difficile toxin A or toxin B specific neutralizing antibody that was below the lower limit of quantitation (LQLO), LO, was assigned a value defined as 0.5×LQQ. The LUQV values in the neutralization assays for toxin A and toxin B were 158.0 neu/ml and 249.5 neu/ml, respectively. No other missing assay data was included in the analyses. All immunogenicity assays were performed after appropriate substitution for antibody levels that were below the LEL. If the level of toxin A-specific neutralizing antibodies was ≥ LEL for toxin A, the subject was considered seropositive for toxin A. If the level of toxin B-specific neutralizing antibodies was ≥ LEL for toxin B, the subject was considered seropositive for toxin B. Conversely, if the antibody level was <LLR, the subject was considered seronegative. Immunogenicity data were summarized according to the vaccine dose determined at randomization. For the initial scheduled stage, all immunogenicity data were summarized separately for each prescribed dosing regimen (days 1, 8 and 30, and months 0, 1 and 6). For each prescribed dosing regimen, 3 vaccination groups (100 µg C difficile , 200 µg C difficile and placebo) were used.

Example 4: Phase 2 Study, 3 Dose Schedule on Days 1, 8, and 30 (daily schedule) or Months 0, 1, and 6 (monthly schedule) (B5091009) - General Study Design and Plan

Approximately 854 healthy adults aged 65-85 were enrolled in the study at approximately 15 centers in the United States as planned. Subjects were assigned to 1 of 2 dosing regimens and then randomized in parallel in a 3:3:1 ratio to either C. difficile vaccine (100 μg or 200 μg) or placebo (saline) (Table 3).

Table 3. Vaccination groups and planned number of subjects per group and per dosing regimen Vaccine group Description of the vaccine preparation Dosing regimen Number of subjects ^1a Aluminum hydroxide-containing C. difficile vaccine (100 mcg dose of antigens) Days 1, 8 and 30 183 ^2a Aluminum hydroxide-containing C. difficile vaccine (200 mcg dose of antigens) Days 1, 8 and 30 183 3 Placebo (saline solution) Days 1, 8 and 30 61 ^4a Aluminum hydroxide-containing C. difficile vaccine (100 mcg dose of antigens) Months 0, 1 and 6 183 ^5a Aluminum hydroxide-containing C. difficile vaccine (200 mcg dose of antigens) Months 0, 1 and 6 183 6 Placebo (saline solution) Months 0, 1 and 6 61 Total 854 a. Subjects in these groups were invited to participate in the extended phase of the study.
Source: Statistical Analysis Plan (version 2.0), Table 4.

A phase 2 study, a placebo-controlled, randomized, observer-blinded study, was conducted to evaluate the safety, tolerability, and immunogenicity of an aluminum hydroxide-containing C. difficile vaccine at 2 dose levels of antigens (toxoid doses of 100 µg and 200 µg total), in the administration of 3 doses either on days 1, 8 and 30 or months 0, 1 and 6, to healthy adults aged 65-85 years. The 100 µg antigen dose level (toxoids A and B combined) and the 200 µg antigen dose level (toxoids A and B combined) were selected for this study because the immunogenicity and safety results from the FIH study (B5091001) showed that antigen dose levels of 100 and 200 μg induced similar immune responses. For the control group, sterile normal saline solution for injection (0.9% sodium chloride) in a volume of 0.5 ml was used as a placebo. Aluminum hydroxide was chosen as the diluent because adsorption to aluminum has been shown to bind and slowly release vaccine components from the injection site.

The study was placebo-controlled (although randomization at the original design stage was advantageous for the active drug groups) to compare the safety and tolerability of the investigational vaccine product, and to monitor any potential change over time in natural background antibodies to toxins A and B C difficile

Using the daily regimen, subjects received 1 dose of C. difficile /placebo vaccine at visits 1 (Day 1), 2 (Day 8), and 4 (Day 30). Using the monthly regimen, subjects received 1 dose of C. difficile /placebo vaccine at visits 1 (day 1), 2 (day 30), and 5 (month 6).

Primary immunogenicity endpoints at Day 37 (7 days post dose 3 for subjects on a daily schedule) and Month 7 (1 month post dose 3 on subjects on a monthly schedule) relative number of subjects in each vaccination group c: toxin A-specific neutralizing antibody level (neutralization units/mL) ≥ toxin A threshold; toxin B-specific neutralizing antibody level (neutralization units/mL) ≥ toxin B threshold; and toxin A and toxin B specific neutralizing antibody levels (neutralization units/mL) ≥ toxin A threshold and toxin B threshold, respectively. Cutoffs were set at 219 u/mL for toxin A and 2586 u/mL for toxin B.

Secondary immunogenicity endpoints at day 37 (7 days post-dose 3 for subjects on a daily schedule) and at month 7 (1 month post-dose 3 on subjects on a monthly schedule): levels of specific toxin A and toxin B neutralizing antibodies, expressed as geometric mean concentrations (SGK) (neutralization units/ml). FGM values at baseline (pre-dose 1) for: toxin A and toxin B specific neutralizing antibodies (neutralization units/mL). Relative numbers of subjects in each vaccination group with ≥4-fold, ≥8-fold, ≥16-fold, and ≥32-fold increases from baseline: toxin A-specific levels; specific for toxin B; and specific for both toxin A and toxin B, neutralizing antibodies (neutralization units/ml). For subjects using a daily regimen, day 1 (immediately prior to dose 1), day 8 (immediately prior to dose 2), day 15 (7 days after dose 2), day 30 (immediately prior to dose 3 ), at month 2 (1 month after dose 3), at month 4 (at 3 months after dose 3), at month 7 (at 6 months after dose 3), and at month 13 (12 months after dose 3); or for subjects using a monthly regimen, day 1 (immediately before dose 1), day 30 (immediately before dose 2), day 37 (7 days after dose 2), month 2 (after 1 month after dose 2), at month 6 (immediately before dose 3), at day 187 (7 days after dose 3), at month 12 (6 months after dose 3), and at month 18 (12 months after dose 3) : relative numbers of subjects in each vaccination group with: toxin A-specific neutralizing antibody level (neutralization units/mL) ≥ toxin A threshold; toxin B-specific neutralizing antibody level (neutralization units/mL) ≥ toxin B threshold; and levels of both toxin A and toxin B specific neutralizing antibodies (neutralization units/mL) ≥ toxin A threshold and toxin B threshold, respectively (these parameters will also be assessed at baseline). Cut-offs were set at 219 neu/ml for toxin A and 2586 neu/ml for toxin B. Toxin A and toxin B specific neutralizing antibody levels expressed as SGV (neutralization units/ml). FGM values at baseline for: toxin A and toxin B specific neutralizing antibody levels (neutralization units/mL). Relative numbers of subjects in each vaccination group with ≥4-fold, ≥8-fold, ≥16-fold, and ≥32-fold increases from baseline: toxin A-specific levels; specific for toxin B; and specific for both toxin A and toxin B, neutralizing antibodies (neutralization units/ml). Baseline values for the above endpoints were the values at the last measurement before the first vaccination on day 1.

Immunogenicity assays. Analyzes in the present study were performed when all subjects completed visit 9 (month 13 for subjects on daily schedules and month 18 for subjects on monthly schedules), and all immunogenicity and safety data up to and including visit 9 were available. In this section, the immunogenicity results are presented separately for the monthly regimen and the daily regimen.

Primary immunogenicity endpoints were: the relative number of subjects in each vaccination arm with toxin A-specific, toxin B, and both toxin A and toxin B titers of neutralizing antibodies ≥ established cut-offs (219 neu/mL for toxin A-specific antibodies and 2586 neu/mL for toxin-specific antibodies) at day 37 (7 days after dose 3 for subjects on a daily regimen) and at month 7 (1 month after dose 3 for subjects on a monthly regimen) . The secondary endpoints of immunogenicity were: levels of toxin A and toxin B specific neutralizing antibodies at all sampling time points, expressed as SGCs. Levels of specific toxin A and toxin B neutralizing antibodies at all sampling time points, expressed as GCMS. Relative numbers of subjects in each vaccination group who achieved a specified fold increase from baseline in levels of toxin A-specific, toxin B, and both toxin A and toxin B neutralizing antibodies at all sampling time points.

Conclusions regarding immunogenicity. Compared to the daily regimen, the monthly regimen achieved a higher immune response at day 187 and month 7 against both toxin A and toxin B. Compared to the monthly regimen, the daily regimen had achieved a higher early immune response at day 37 and month 2 against toxin A, but responses against toxin B were similar at these time points. The 200 μg dose level was more immunogenic than the 100 μg dose level for both regimens. In the case of toxin A, baseline seropositivity could increase the intensity of the immune response shortly after dose 1 (particularly at the 100 µg dose level), but there was little difference in immune response after dose 3 in both regimens compared to those in subjects who were seronegative at baseline. against toxin A. In the case of toxin B, baseline seropositivity increased the intensity of the immune response in both regimens. The relative numbers of subjects that achieved both toxin A and toxin B specific neutralizing antibody levels ≥ cut-offs at month 7 using the monthly regimen or day 37 using the daily regimen were similar at stratified by age quintile 65-85 (although the number of subjects aged 80-85 was small).

This was a phase 2 study, a placebo-controlled, randomized, observer-blinded trial to evaluate the safety, tolerability, and immunogenicity of an aluminum hydroxide-containing C. difficile vaccine at 2 dose levels of antigens (toxoid doses of 100 µg and 200 µg total) in the administration of 3 doses: either on days 1, 8 and 30 (daily regimen) or in months 0, 1 and 6 (monthly regimen). Overall, the C. difficile vaccine was highly immunogenic, well tolerated, and had an acceptable safety profile.

Discussion of the results of determination of immunogenicity. The primary objective of the immunogenicity study in this study was to determine the immunogenicity of the C. difficile vaccine at 2 antigen dose levels (toxoid total doses of 100 µg and 200 µg) in a 3 dose schedule (either on days 1, 8 and 30, or on months 0 , 1 and 6) in healthy adults aged 65-85 years based on measurements of C. difficile toxin A and toxin B specific neutralizing antibodies on day 37 (7 days after dose 3) on a daily regimen, and also on based on measurement of levels of specific C. difficile toxin A and toxin B neutralizing antibodies at month 7 (1 month after dose 3) on a monthly schedule. Immunogenicity was assessed by measuring toxin A and toxin B specific neutralizing antibody titers throughout the study. The results were expressed as GBS, the relative numbers of subjects that achieved different fold titers, and the relative numbers of subjects that achieved titers above the set threshold for each toxin.

In both the monthly and daily regimens, doses of 100 µg and 200 µg of C. difficile antigens were immunogenic compared to placebo. The 200 μg dose level was more immunogenic than the 100 μg dose level, as judged based on the intensity and duration of response.

The relative numbers of subjects on the monthly regimen who achieved titers above the set threshold for each toxin were highest at day 187 (1 week after dose 3) and month 7 (1 month after dose 3) as in the case of toxin A and toxin B.

The relative numbers of subjects on the daily regimen that achieved titers above the set threshold for toxin A were higher at day 37 and month 2 for toxin A, but the relative numbers of subjects were similar at these time points for toxin B .

Prior to vaccination, the majority of subjects on both dosing regimens were seronegative for toxin A and for toxin B. In the monthly dosing regimen, 69.8% of subjects were seronegative, 8.7% of subjects were seropositive for toxin A only, 19.0% subjects were seropositive for toxin B only and 2.6% of subjects were seropositive for both toxin A and toxin B. In the daily dosing regimen, 75.4% of subjects were seronegative, 4.9% of subjects were seropositive for only toxin A, 16.4% of subjects were seropositive for toxin B only and 3.0% of subjects were seropositive for both toxin A and toxin B.

In the case of toxin A, baseline seropositivity could increase the intensity of the immune response shortly after dose 1 (particularly at the 100 μg dose level), however, there was little difference in immune response after dose 3 in both regimens compared to those in subjects who were seronegative at baseline. for toxin A.

In the case of toxin B, baseline seropositivity increased the intensity of the immune response in both regimens. In subjects who were initially seronegative for toxin B, only the third dose administered at month 6 resulted in a significant relative number of subjects reaching the threshold.

The relative numbers of subjects that achieved both toxin A and toxin B specific neutralizing antibody levels ≥ cut-offs at month 7 using the monthly dosing regimen, or at day 37 using the daily dosing regimen were similar when stratified by age quintile 65-85 (although the number of subjects aged 80-85 was small).

The 200 μg dose level was quantitatively more immunogenic than the 100 μg dose level in both dosing regimens.

The monthly dosing regimen resulted in a higher response after dose 3 at both dose levels, 100 μg and 200 μg, especially for toxin B in subjects who were sero-negative at baseline.

The relative numbers of subjects that achieved levels of both toxin A and toxin B specific neutralizing antibodies ≥ cutoffs were similar when stratified by age quintile 65-85 years (although the number of subjects aged 80-85 years was small). ).

Example 5 Phase 2 Study, 3 Dose Schedule at Days 1, 8, and 30 (Daily Schedule) or Months 0, 1, and 6 (Monthly Schedule) (B5091009) - Immunogenicity Evaluation, Monthly Schedule

Monthly introduction mode. The relative numbers of subjects achieving toxin A specific titers, toxin B specific titers, and both toxin A and toxin B neutralizing antibody titers ≥ established thresholds, depending on the subject's baseline serostatus, were assessed for a monthly regimen. All (100.0%) randomized subjects were assessed for baseline serostatus. Most were sero-negative for both toxin A and toxin B at baseline. Among the sero-negative subjects at baseline, the relative number of subjects who achieved toxin A-specific neutralizing antibody titers ≥ the established threshold reached 98.0% at month 7 in the administration group 100 µg C. difficile antigens and 95.0% at month 7 in the 200 µg C. difficile antigens injection group. The relative number of subjects achieving toxin B-specific neutralizing antibody titers ≥ the established cut-off reached 69.4% at month 7 in the 100 µg C. difficile antigens group and 85.0% at month 7 in the 200 µg group C. difficile antigens. Among baseline seropositive subjects, the relative proportion of subjects achieving toxin A-specific neutralizing antibody titers ≥ the cut-off reached 100.0% at month 7 in the 100 µg C. difficile antigens group and 100.0% at month 7 at group receiving 200 µg of C. difficile antigens. The relative number of subjects who achieved toxin B-specific neutralizing antibody titers ≥ the established cut-off was 100.0% at day 187 and month 7 in the 100 µg C. difficile antigens group and 96.8% at day 37, month 2 and month 7 in the 200 µg C. difficile antigens group.

For toxin A, at month 7 on a monthly schedule, 160 subjects (95% CI: 94.7%; 99.6%) in the 100 μg C. difficile antigens group and 151 subjects (95% CI: 91 .1%; 98.2%) in the 200 μg C. difficile antigens group, the established threshold was reached, compared with 1 subject (95% CI: 0.0%; 10.1%) in the placebo group.

For toxin B, at month 7 on a monthly schedule, 122 (74.8%) subjects (95% CI: 67.5%; 81.3%) in the 100 μg C. difficile antigens group and 138 ( 87.3%) of subjects (95% CI: 81.1%; 92.1%) in the 200 μg C. difficile antigens group reached the target threshold compared to 4 (7.5%) subjects (95% CI: 2.1%; 18.2%) in the placebo group.

For both toxin A and toxin B, at month 7 on a monthly schedule in 121 (74.2%) subjects (95% CI: 66.8%; 80.8%) in the 100 μg C antigens group difficile and 136 (86.1%) subjects (95% CI: 79.7%; 91.1%) in the 200 μg C. difficile antigens group reached the established cut-off point compared with no such subjects (95 % CI: 0.0%; 6.7%) in the placebo group.

In the monthly regimen, 1 subject in the 100 μg C. difficile antigens group, 2 (1.3%) subjects in the 200 μg C. difficile antigens group, and 1 subject in the placebo group had toxin A-specific neutralizing antibody levels ≥ set threshold. After doses 1 and 2, but before dose 3, the relative numbers of subjects that reached the threshold for toxin A-specific antibodies were limited, with 71 (43.6%) subjects (95% CI: 35.8%; 51.5%) in the 100 µg C. difficile antigens group and 89 (56.7%) subjects (95% CI: 48.6%; 64.6%) in the 200 µg C. difficile antigens day 37 group After dose 3, the relative numbers of subjects who reached this threshold increased at day 187. In the 100 μg C. difficile antigens group at month 7, 160 (98.2%) subjects reached the toxin-specific threshold A antibodies, and the relative number of subjects who reached the cut-off, decreased to 75 (48.7%) subjects at month 18. In the 200 µg C. difficile antigens at month 7 group, 151 (95.6%) subjects threshold for toxin A-specific antibodies was reached, and the relative number of subjects who had o threshold reached, decreased to 81 (53.3%) subjects at month 18.

In a monthly regimen, 4 (2.5%) subjects in the 100 µg C. difficile antigens group, 7 (4.4%) subjects in the 200 µg C. difficile antigens group, and 2 (3.8%) subjects in the placebo group at baseline had levels of toxin B-specific neutralizing antibodies ≥ the established threshold. After doses 1 and 2 but before dose 3, 47 (28.8%) subjects (95% CI: 22.0%; 36.4%) in the 100 μg C. difficile antigens group reached the daily threshold 37 and at month 2, and 60 (38.2%) subjects (95% CI: 30.6%; 46.3%) in the 200 μg C. difficile antigens group reached the threshold at day 37. Post-dose 3, the relative number of subjects who reached this threshold increased at day 187. In the 100 µg C. difficile antigens group at month 7, 122 (74.8%) subjects reached the threshold for toxin B-specific antibodies, and the relative number of subjects who reached the threshold decreased to 53 (34.4%) subjects at month 18. In the 200 μg C. value for toxin B-specific antibodies, and the relative number of subjects in whom this threshold was reached decreased up to 72 (47.4%) subjects in month 18.

Overall, the results for the relative number of subjects that achieved levels of both toxin A and toxin B specific neutralizing antibodies ≥ the established thresholds were similar to those for toxin B.

Toxin A and toxin B specific neutralizing antibodies were estimated at geometric mean concentrations (GMCs) at each time point. On a monthly regimen, the GAM value of toxin A-specific neutralizing antibodies was lower than the LLR (158.0 neu/mL) at baseline in subjects in the 100 µg C. difficile antigen, 200 µg C. difficile antigen, and placebo groups. Compared to baseline, in subjects in the 100 µg C. difficile antigens group, an increase in GBS was observed on day 30 (137 neu/mL), peaked at month 7 (1245 u/mL), and decreased to 214 u/mL. ml at month 18. Compared to baseline in subjects in the 200 µg C. difficile antigens group, an increase in GBS was observed on day 30 (149 u/ml), peaked at month 7 (1380 u/ml) and decreased to 257 neu/mL at month 18. Toxin A-specific neutralizing antibody SCR values in the placebo group were ≥93 neu/mL at all time points.

In a monthly regimen, the GAM value of toxin B-specific neutralizing antibodies at baseline was lower than the LUQV (249.5 neu/mL) in subjects in the 100 µg C. difficile antigen, 200 µg C. difficile antigen, and placebo groups. Compared to baseline, in subjects in the 100 μg C. difficile antigens group, an increase in GCS was observed on day 30 (570 neu/ml), peaked at month 7 (6255 neu/ml), and decreased to 1248 neu/mL. ml at month 18. Compared to baseline, subjects in the 200 μg C. difficile antigens group experienced an increase in BGC at day 30 (909 u/ml), peaked at month 7 (9549 u/ml), and decreased to 2178 neu/mL at month 18. Toxin A-specific neutralizing antibody SGD values in the placebo group were ≥263 neu/mL at all time points.

On a monthly regimen, at all visits after the start of the study, toxin A-specific neutralizing antibody GCR values were higher in the 200 μg C. difficile antigens than in the 100 μg C. difficile antigens group. In both 100 µg and 200 µg C. difficile antigen groups, post-study GBS values were higher than in the placebo group; however, there was no clear dose-response relationship in the 100 µg and 200 µg C. difficile antigen groups. On a monthly regimen, at all visits after study initiation, toxin B-specific neutralizing antibody GCR values were higher in the 200 μg C. difficile antigens than in the 100 μg C. difficile antigens group. In both 100 µg and 200 µg C. difficile antigens groups, post-study GBS values were higher than in the placebo group. A clear dose-response relationship was observed in the 100 μg and 200 μg C. difficile antigens treatment groups after dose 3 (at month 12 and month 18). Toxin A-specific and toxin-B specific neutralizing antibody GCR values as a function of subjects' baseline serostatus were summarized for a monthly regimen. Toxin A-specific and toxin-B-specific neutralizing antibody GCR values by age and baseline serostatus of subjects were summarized for a daily regimen.

For the administration regimen by months, the values of the geometric mean fold increase (GMC) of titers specific for toxin A and toxin B of neutralizing antibodies from baseline values were calculated on day 30, day 37, month 2, month 6, day 187, month 7 , in month 12 and in month 18.

After dose 2, an increase in FMC values for toxin A-specific neutralizing antibodies was observed on day 37 (100 µg C. difficile antigens group, 2.70; 200 µg C. difficile antigens, 3.78 group). After dose 3, a booster response was observed on day 187 (100 µg C. difficile antigens group, 5.85; 200 µg C. difficile antigens group, 8.54). This booster response was maximal at month 7 (1 month post-dose 3), with GCMS scores of 14.58 in the 100 µg C. difficile antigens group and 15.85 in the 200 µg C. difficile antigens group. MCMS values decreased to 2.51 in the 100 µg C. difficile antigens group and to 2.95 in the 200 µg C. difficile antigens group at month 18.

After dose 2, an increase in FMC values for toxin B-specific neutralizing antibodies was observed at day 37 (100 µg C. difficile antigens group, 3.75; 200 µg C. difficile antigens, 5.59 group). After dose 3, a significant booster response was observed at day 187 (100 µg C. difficile antigens group, 15,85; 200 µg C. difficile antigens group, 24,44). This booster response was maximal at month 7 (1 month post-dose 3), with GCMS scores of 35.43 in the 100 µg C. difficile antigens group and 49.98 in the 200 µg C. difficile antigens group. MCMS values decreased to 7.07 in the 100 µg C. difficile antigens group and to 11.21 in the 200 µg C. difficile antigens group at month 18.

From day 30 to month 18, FMC values for toxin A and toxin B specific neutralizing antibodies were higher in the 200 μg C. difficile antigens than in the 100 μg C. difficile antigens group.

The values of SGCM for specific toxin A and toxin B neutralizing antibodies at each time point, depending on the initial serostatus of the subjects were assessed for the regimen of administration by months. In baseline sero-negative subjects, an increase in GMCC values for toxin A-specific neutralizing antibodies was observed at day 37 (100 μg C. difficile antigens, 2.74; 200 μg C. difficile antigens, 4.07). After dose 3, a booster response was observed on day 187 (100 µg C. difficile antigens group, 6,29; 200 µg C. difficile antigens group, 9,37). This booster response was maximal at month 7, with GCMS scores of 15.88 in the 100 µg C. difficile antigens group and 17.32 in the 200 µg C. difficile antigens group. The FMC values decreased to 2.59 in the 100 µg C. difficile antigens group and to 3.12 in the 200 µg C. difficile antigens group at month 18. After dose 2, the FMC values for toxin B-specific neutralizing antibodies were equal in the administration group. 100 µg C. difficile antigens (day 30: 2.45; day 37: 2.67; month 2: 2.79) and 200 µg C. difficile antigens (day 30: 3.40; per day 37: 3.95; in month 2: 3.94). After dose 3, a significant booster response was observed on day 187 (100 µg C. difficile antigens group, 16.00; 200 µg C. difficile antigens group, 26.67). This booster response was maximal at month 7, with GCMS scores of 39.29 in the 100 µg C. difficile antigens group and 61.04 in the 200 µg C. difficile antigens group. MCMS values decreased to 6.95 in the 100 µg C. difficile antigens group and to 11.57 in the 200 µg C. difficile antigens group at month 18.

In seropositive subjects at baseline, an increase in FCC values for toxin A-specific neutralizing antibodies was observed on day 37 (100 μg C. difficile antigens group, 2.37; 200 μg C. difficile antigens group, 2.13). After dose 3, a booster response was observed on day 187 (100 µg C. difficile antigens group, 3.03; 200 µg C. difficile antigens group, 4.18). This booster response was maximal at month 7, with GCMS scores of 6.65 in the 100 µg C. difficile antigens group and 7.96 in the 200 µg C. difficile antigens group. FMC values decreased to 1.87 in the 100 μg C. difficile antigens group and to 1.91 in the 200 μg C. difficile antigens group at month 18. After dose 2, an increase in FMC values for toxin B-specific neutralizing antibodies was observed per day 37 (100 µg C. difficile antigens group, 17.97; 200 µg C. difficile antigens administration group, 23.01). After dose 3, a significant booster response was observed at month 7 (100 µg C. difficile antigens group, 21.96; 200 µg C. difficile antigens group, 21.99). This booster response was maximal at month 7. MCMS values decreased to 7.68 in the 100 µg C. difficile antigens group and to 9.91 in the 200 µg C. difficile antigens group at month 18.

From day 30 to month 18, the FMC values for toxin A-specific neutralizing antibodies were higher in the 200 µg C. difficile antigens group than in the 100 µg C. difficile antigens group, except for values on day 30 and day 37 in baseline seropositive subjects. After day 187, SGCT values for toxin A-specific neutralizing antibodies were higher in baseline sero-negative subjects in both dose groups compared to baseline seropositive subjects. From day 30 to month 18, the SGCT values for toxin B-specific neutralizing antibodies in baseline seronegative and seropositive subjects were higher in the 200 µg C. difficile antigens group than in the 100 µg C. difficile antigens group. From day 30 to month 6, the FMC values for toxin B-specific neutralizing antibodies were higher in baseline seropositive subjects compared to baseline seronegative subjects, but from day 187 to month 18, the FMC values for toxin B-specific neutralizing antibodies were higher in baseline sero-negative subjects compared to baseline seropositive subjects.

The relative numbers of subjects who achieved the established fold increase from baseline levels of toxin A-specific, toxin B, and both toxin A and toxin B neutralizing antibodies at day 37 and at other sampling time points were summarized.

In general, greater relative numbers of subjects who achieved the established fold increase from baseline toxin A-specific neutralizing antibody levels were observed in the 200 µg C. difficile antigens group than in the 100 µg C. difficile antigens group. In the 100 μg C. difficile antigens group, an increase in the relative numbers of subjects achieving a ≥4-fold increase was observed from day 37, with 125 (76.7%) subjects achieving a ≥8-fold increase at month 7 In the 100 μg C. difficile antigens group, 77 (47.2%) subjects achieved a ≥16-fold increase, and 33 (20.2%) subjects achieved a ≥32-fold increase in toxin A-specific neutralizing antibodies at month 7. In the 200 µg C. difficile antigens group, an increase in the relative numbers of subjects who achieved a ≥4-fold increase was observed from day 37, with a significant increase in the relative number of subjects who achieved a ≥8-fold increase per day 187. In the 200 μg C. difficile antigens group, 89 (56.3%) subjects achieved a ≥16-fold increase, and 34 (21.5%) subjects achieved a ≥32-fold increase in levels specific for toxin A neutralizing antibodies in month 7.

In general, higher relative numbers of subjects who achieved the stated fold increase from baseline toxin B-specific neutralizing antibody levels were observed in the 200 µg C. difficile antigens group than in the 100 µg C. difficile antigens group. In the 100 µg C. difficile antigens group, an increase in the relative numbers of subjects who achieved a ≥4-fold increase was observed from day 37, with 138 (84.7%) subjects achieving a ≥8-fold increase at month 7 In the 100 μg C. difficile antigens group, 85 (52.5%) subjects achieved ≥16-fold, and 52 (32.1%) subjects achieved ≥32-fold, increases in toxin B-specific neutralizing antibodies on day 187. In the 200 μg C. difficile antigens group, an increase in the relative numbers of subjects who achieved a ≥4-fold increase was observed from day 187, with a significant increase in the relative number of subjects who achieved a ≥8-fold increase per day 187. For the 200 µg C. difficile antigens group, 105 (66.5%) subjects in the 200 µg C. difficile antigens group achieved a ≥32-fold increase in toxin B-specific neutralization levels. developing antibodies in month 7.

Overall, the results for the relative number of subjects who achieved the established fold increase from baseline levels of both toxin A and toxin B specific neutralizing antibodies were similar to those for toxin A.

Inverse Cumulative Distribution Curves (IRDCs) representing data for toxin A-specific neutralizing antibody levels measured on Day 1, Day 30, Day 37, Month 2, Month 6, Day 187, Month 7, Month 12 and at month 18, depending on the vaccination groups were evaluated for the administration schedule by month. KOIR reporting data for toxin B-specific neutralizing antibody levels measured on Day 1, Day 30, Day 37, Month 2, Month 6, Day 187, Month 7, Month 12, and Month 18, depending on the vaccination groups were evaluated for the administration regimen by months. In general, a curve shift to the right was observed for the vaccinated groups, indicating that immunization with the toxoid vaccine resulted in increased titer levels relative to those observed with placebo. These data were consistent with data on GBS and the relative number of subjects who achieved levels ≥ the established thresholds.

Example 6 Phase 2 Study, 3 Dose Schedule on Days 1, 8, and 30 (Daily Schedule) or Months 0, 1, and 6 (Monthly Schedule) (B5091009) - Immunogenicity Evaluation, Daily Schedule

Mode of administration by day . The relative numbers of subjects that achieved toxin A-specific, toxin B, and both toxin A and toxin B specific neutralizing antibody titers ≥ the established thresholds, depending on the subject's baseline serostatus, were estimated for the daily regimen. The majority of subjects were seronegative for both toxin A and toxin B at baseline. Among the seronegative subjects at baseline, the relative number of subjects who achieved toxin A-specific neutralizing antibody titers ≥ the established cut-off reached 67.7% on day 37 in the group 100 µg C. difficile antigens and 85.2% on day 37 and month 2 in the 200 µg C. difficile antigens group. The relative number of subjects achieving toxin B-specific neutralizing antibody titers ≥ the set cut-off was 14.0% on day 15 and day 37 in the 100 μg C. difficile antigens group and 25.2% on day 37 in the administration of 200 µg of C. difficile antigens. In seropositive subjects at baseline, the relative numbers of subjects achieving toxin A-specific neutralizing antibody titers ≥ set cut-off reached 80.0% on day 37 in the 100 μg C. difficile antigens group and 86.7% on day 37 and month 2 in the 200 µg C. difficile antigens group. The relative numbers of subjects achieving toxin B-specific neutralizing antibody titers ≥ the established cut-off were 97.1% on day 30 in the 100 μg C. difficile antigens group and 93.9% on day 37 and month 2 in the administration of 200 µg of C. difficile antigens.

For toxin A, on day 37 on a daily schedule, 117 (68.4%) subjects (95% CI: 60.9%; 75.3%) in the 100 µg C. difficile antigens group and 141 ( 85.5%) of the subject (95% CI: 79.1%; 90.5%) in the 200 μg C. difficile antigens group reached the target threshold compared to 7 (12.5%) subjects (95% CI: 5.2%; 24.1%) in the placebo group.

For toxin B, on day 37 on a daily schedule, 51 (29.8%) subjects (95% CI: 23.1%; 37.3%) in the 100 μg C. difficile antigens group and 64 ( 38.8%) of subjects (95% CI: 31.3%; 46.7%) in the 200 μg C. difficile antigens group reached the target threshold compared to 1 subject (95% CI: 0.0% ; 9.6%) in the placebo group.

For both toxin A and toxin B, on day 37 on a daily regimen in 45 (26.3%) subjects (95% CI: 19.9%; 33.6%) in the 100 µg C antigens group difficile and 64 (38.8%) subjects (95% CI: 31.3%; 46.7%) in the 200 µg C. difficile antigens group achieved the cut-off point compared with no such subjects (95 % CI: 0.0%; 6.4%) in the placebo group.

In the daily regimen, 2 (1.2%) subjects in the 100 µg C. difficile antigens group and 1 subject in the 200 µg C. difficile antigens group had toxin A-specific neutralizing antibody levels ≥ the established cut-off at baseline. After doses 1 and 2, but before dose 3, the relative numbers of subjects who reached the threshold for toxin A-specific antibodies were limited, with 29 (17.0%) subjects (95% CI: 11.7%; 23.4%) in the 100 μg C. difficile antigens group and 41 (25.0%) subjects (95% CI: 18.6%; 32.3%) in the 200 μg C. difficile antigens on day 15 group After dose 3, the relative number of subjects who reached this threshold increased on day 37. In the 100 µg C. difficile antigens group on day 37, 117 (68.4%) subjects reached the toxin-specific threshold A antibodies, and the relative number of subjects who reached the threshold decreased to 16 (10.1%) subjects at month 13. In the 200 μg C. difficile antigens group on day 37 and 5%) of the subject has reached the threshold for toxin A-specific antibodies, and the relative number of subjects who have of whom this threshold was reached decreased to 40 (25.8%) subjects at month 13.

On a daily regimen, 8 (4.7%) subjects in the 100 µg C. difficile antigens group, 6 (3.7%) subjects in the 200 µg C. difficile antigens group, and 3 (5.4%) subjects in the placebo group had levels of toxin B-specific neutralizing antibodies ≥ the established threshold at baseline. After doses 1 and 2 but before dose 3, 52 (30.4%) subjects (95% CI: 23.6%; 37.9%) in the 100 µg C. difficile antigens group and 61 (37, 2%) of the subject (95% CI: 29.8%; 45.1%) in the 200 μg C. difficile antigens group reached the cut-off on day 15. After dose 3, the relative number of subjects who reached this cut-off remained stable until day 37. In the 100 μg C. difficile antigens group on days 30 and 37, 51 (29.8%) subjects reached the threshold for toxin B-specific antibodies, and the relative number of subjects who had threshold reached, decreased to 31 (19.6%) subjects at month 13. In the 200 μg C. difficile antigens on day 37 group, 64 (38.8%) subjects reached the threshold for toxin B-specific antibodies, and the relative number of subjects who met this threshold decreased to 48 (31.0%) subjects at month 13.

Overall, the results for the relative number of subjects that achieved levels of both toxin A and toxin B specific neutralizing antibodies ≥ the established thresholds were similar to those for toxin B.

Toxin A-specific and toxin-B specific neutralizing antibodies were assessed at each time point. On a daily regimen at baseline, the GAM value of toxin A-specific neutralizing antibodies was lower than the LEL (158.0 neu/mL) in subjects in the 100 µg C. difficile antigen, 200 µg C. difficile antigen, and placebo groups. Compared to baseline in subjects in the 100 µg C. difficile antigens group, an increase in GCS was observed on day 15 (143 u/mL), peaked at day 37 (368 u/mL), and decreased to 105 u/mL at month 13. Compared to baseline in subjects in the 200 μg C. difficile antigens group, an increase in GCS was observed on day 15 (192 neu/mL), peaked at day 37 (556 neu/mL) and decreased to 138 neu/mL at month 13. Toxin A-specific neutralizing antibody SCR values in the placebo group were ≤102 neu/mL at all time points.

On a daily regimen at baseline, the GAM value of toxin B-specific neutralizing antibodies was lower than the LEL (249.5 neu/mL) in subjects in the 100 µg C. difficile antigen, 200 µg C. difficile antigen, and placebo groups. Compared to baseline in subjects in the 100 μg C. difficile antigens group, an increase in GBS was observed on day 8 (273 u/mL), peaked at day 15 (807 u/mL), and decreased to 447 u/mL at month 13. Compared to baseline in subjects in the 200 μg C. difficile antigens group, an increase in GBS was observed on day 8 (290 neu/mL), peaked at day 37 (1219 u/mL) and decreased to 828 neu/mL at month 13. Toxin A-specific neutralizing antibody SGD values in the placebo group were ≥211 neu/mL at all time points.

On a daily regimen, at all visits after study initiation, toxin A-specific neutralizing antibody GCR values were higher in the 200 μg C. difficile antigens than in the 100 μg C. difficile antigens group. In both 100 µg and 200 µg C. difficile antigen groups, post-study GBS values were higher than in the placebo group; and a clear dose-response relationship was observed in the 100 µg and 200 µg C. difficile antigen groups.

On a daily regimen, at all visits after study initiation, toxin B-specific neutralizing antibody GCS values were higher in the 200 μg C. difficile antigens than in the 100 μg C. difficile antigens group. In both 100 µg and 200 µg C. difficile antigen groups, post-study GBS values were higher than in the placebo group; however, there was no clear dose-response relationship in the 100 µg and 200 µg C. difficile antigen groups.

Toxin A-specific and toxin-B specific neutralizing antibody GCR values as a function of subjects' baseline serostatus were summarized for a daily regimen. Toxin A-specific and toxin-B-specific neutralizing antibody GCR values by age and baseline serostatus of subjects were summarized for a daily regimen.

For the daily regimen, the geometric mean fold increase (GMF) from baseline toxin A and toxin B specific neutralizing antibody concentrations was calculated at day 8, day 15, day 30, day 37, month 2, month 4 , at month 7, and at month 13. After dose 2, an increase in FMC values for toxin A-specific neutralizing antibodies was observed on day 15 (100 µg C. difficile antigens group, 1.73; 200 µg C. difficile antigens, 2 group). ,27). After dose 3, a booster response was observed on day 37 (100 µg C. difficile antigens group, 4.45; 200 µg C. difficile antigens group, 6.56). This booster response was maximal at day 37 (7 days after dose 3) and the value was 3.56 in the 100 µg C. difficile antigens group and 5.71 in the 200 µg C. difficile antigens group at month 2. Values The MMC decreased to 1.26 in the 100 µg C. difficile antigens group and to 1.64 in the 200 µg C. difficile antigens group at month 13.

After dose 2, a marked increase in FMC values for toxin B-specific neutralizing antibodies was observed on day 15 (100 μg C. difficile antigens group, 4.31; 200 μg C. difficile antigens group, 5.86). After dose 3, a booster response was observed on day 37 in the 200 μg C. difficile antigens group (GMC 6.57), but the MC values were equal in the 100 μg C. difficile antigens group (day 30: 3.76; day 37 : 3.89; in month 2: 3.61). This booster response was maximal at day 37 (7 days after dose 3) in the 200 µg C. difficile antigens group. MCGS values decreased to 2.40 in the 100 µg C. difficile antigens group and to 4.44 in the 200 µg C antigens group . difficile in month 13.

From day 8 to month 13, the FMC values for toxin A and toxin B specific neutralizing antibodies were higher in the 200 μg C. difficile antigens than in the 100 μg C. difficile antigens group.

Toxin A and toxin B-specific neutralizing antibodies as a function of baseline serostatus of subjects at each time point were evaluated for the daily regimen. Among seronegative subjects at baseline, an increase in FCC values for toxin A-specific neutralizing antibodies was observed at day 30 (100 µg C. difficile antigens group, 2.01; 200 µg C. difficile antigens, 2.95 group). After dose 3, a booster response was observed on day 37 (100 µg C. difficile antigens group, 4.48; 200 µg C. difficile antigens group, 6.95). This booster response was maximal at day 37. The MCL values decreased to 1.28 in the 100 μg C. difficile antigens group and to 1.75 in the 200 μg C. difficile antigens group at month 13. After dose 2, an increase in MCL values for toxin B-specific neutralizing antibodies were observed on day 15 (100 µg C. difficile antigens group, 2.57; 200 µg C. difficile antigens group, 3.81). After dose 3, the MCGS values were equal in the 100 µg C. difficile antigen group (day 30: 2.37; day 37: 2.56; month 2: 2.42) and in the 200 µg C. difficile antigen group (on day 30: 3.68; day 37: 4.55; in month 2: 4.22). MCMS values decreased to 2.01 in the 100 µg C. difficile antigens group and to 4.00 in the 200 µg C. difficile antigens group at month 13.

Among seropositive subjects at baseline, an increase in FCC values for toxin A-specific neutralizing antibodies was observed at day 30 (100 μg C. difficile antigens group, 2.47; 200 μg C. difficile antigens group, 1.20). After dose 3, a booster response was observed on day 37 (100 μg C. difficile antigens group, 3.97; 200 μg C. difficile antigens group, 3.68). This booster response was maximal at day 37. MMC values decreased to 0.99 in the 100 μg C. difficile antigens group and to 0.81 in the 200 μg C. difficile antigens group at month 13. After dose 2, a marked increase in MMC values for toxin B-specific neutralizing antibodies was observed on day 15 (100 µg C. difficile antigens injection group, 32,18; 200 µg C. difficile antigens injection group, 32,14). A booster response was not evident after dose 3, as the SGCT values were equal in the 100 μg C. difficile antigens group (at day 30: 22.86; at day 37: 19.74; at month 2: 17.23) and in the administration of 200 µg of C. difficile antigens (on day 30: 27.50; on day 37: 28.23; on month 2: 25.54). MCMS values decreased to 4.72 in the 100 µg C. difficile antigens group and to 6.70 in the 200 µg C. difficile antigens group at month 13.

From day 8 to month 13, the SGCT values for toxin A-specific neutralizing antibodies in initially seronegative subjects were higher in the 200 μg C. difficile antigens than in the 100 μg C. difficile antigens group. From day 8 to month 13, the FMC values for toxin A-specific neutralizing antibodies in initially seropositive subjects were lower in the 200 µg C. difficile antigens group than in the 100 µg C. difficile antigens group, except at month 4. The FMC values for Toxin A-specific neutralizing antibodies were higher in baseline sero-negative subjects in both dose groups compared to baseline seropositive subjects. From day 8 to month 13, the SGCT values for toxin B-specific neutralizing antibodies in sero-negative and seropositive subjects at baseline were higher in the 200 µg C. difficile antigens group than in the 100 µg C. difficile antigens group, except on day 15 at baseline. seropositive subjects. From day 8 to month 13, the SGCT values for toxin B-specific neutralizing antibodies were higher in baseline seropositive subjects than in baseline seronegative subjects.

The relative numbers of subjects who achieved the established fold increase from baseline levels of toxin A-specific, toxin B, and both toxin A and toxin B neutralizing antibodies at day 37 and at other blood sampling time points were summarized.

In general, greater relative numbers of subjects who achieved the established fold increase from baseline toxin A-specific neutralizing antibody levels were observed in the 200 µg C. difficile antigens group than in the 100 µg C. difficile antigens group. In the 100 μg C. difficile antigens group, an increase in the relative numbers of subjects achieving a ≥4-fold increase was observed from day 15, with 43 (25.1%) subjects achieving a ≥8-fold increase on Day 37 In the 100 μg C. difficile antigens group, 15 (8.8%) subjects achieved a ≥16-fold increase, and 6 (3.5%) subjects achieved a ≥32-fold increase in toxin A-specific neutralizing antibodies on day 37. In the 200 μg C. difficile antigens group, an increase in the relative numbers of subjects in which a ≥4-fold increase was achieved was observed from day 15, with a marked increase in the relative number of subjects (67 [40.0%]), who achieved a ≥8-fold increase on day 37. In the 200 µg C. difficile antigens group, 23 (14.1%) subjects achieved a ≥16-fold increase and 15 (9.2%) subjects had achieved ≥32-fold increase in toxin A-specific levels neutralizing antibodies on day 15.

In general, similar relative numbers of subjects who achieved established fold increase from baseline levels of toxin B-specific neutralizing antibodies were observed in the 100 µg C. difficile antigens and 200 µg C. difficile antigens group up to month 4. At months 7 and 13, greater relative numbers of subjects who achieved the established fold increase from baseline levels of toxin A-specific neutralizing antibodies were observed in the 200 µg C. difficile antigens group than in the 100 µg C. difficile antigens group. In the 100 µg C. difficile antigens group, an increase in the relative numbers of subjects that achieved a ≥4-fold increase was observed from day 15, with 57 (33.3%) subjects achieving a ≥8-fold increase on day 15 and day 30. In the 100 μg C. difficile antigens group, 45 (26.3%) subjects achieved a ≥16-fold increase, and 35 (20.5%) subjects achieved a ≥32-fold increase in levels specific for toxin A neutralizing antibodies on day 15. In the 200 µg C. difficile antigens group, an increase in the relative numbers of subjects in which a ≥4-fold increase was achieved was observed from day 15, with a marked increase in the relative number of subjects (66 [40.2% ]), who achieved a ≥8 -fold increase on Day 37. ) subjects achieved a ≥32-fold increase in the levels of specific for toxin A neutralizing antibodies on day 30 and day 37.

Overall, the results for the relative number of subjects who achieved the established fold increase from baseline levels of both toxin A and toxin B specific neutralizing antibodies were similar to those for toxin A.

Inverse Cumulative Distribution Curves (IRDCs) representing data for toxin A-specific neutralizing antibody levels measured on Day 1, Day 8, Day 15, Day 30, Day 37, Month 2, Month 4, Month 7 and at month 13, depending on the vaccination group, were evaluated for the daily regimen. KOIR reporting data for toxin B-specific neutralizing antibody levels measured on Day 1, Day 8, Day 15, Day 30, Day 37, Month 2, Month 4, Month 7, and Month 13, depending on the vaccination groups were evaluated for the daily regimen. In general, a curve shift to the right was observed for the vaccinated groups, indicating that immunization with the toxoid vaccine resulted in increased titer levels relative to those observed with placebo. These data were consistent with data on GBS and the relative number of subjects who achieved levels ≥ the established thresholds.

Example 7 Phase 2 Study, 3 Dose Schedule at Days 1, 8, and 30 (Daily Schedule) or Months 0, 1, and 6 (Monthly Schedule) (B5091009) - Immunogenicity Evaluation, Results by Age Group

The immune response was also assessed depending on the age group (65-69 years old, 70-74 years old, 75-79 years old and 80-85 years old).

In the monthly regimen in month 7, the relative numbers of subjects in the 100 μg C. difficile antigens administration group who achieved both toxin A and toxin B specific neutralizing antibody titers ≥ the established thresholds were 80.0% of 70 subjects aged 65-69, 68.8% of 48 subjects aged 70-74, 73.5% of 34 subjects aged 75-79, and 63.6% of 11 subjects aged 80-85 years. The corresponding relative numbers of subjects in the 200 µg C. difficile antigens group were 90.6% of 64 subjects aged 65-69 years, 83.9% of 56 subjects aged 70-74 years, 89.7% of 29 subjects in aged 75-79 years and 55.6% of 9 subjects aged 80-85 years.

On a monthly regimen in month 7, the SGD values of toxin A-specific neutralizing antibodies in subjects in the 100 μg C. difficile antigens administration group were 1304 neu/ml in subjects aged 65-69 years, 1182 neu/ml in subjects in age 70-74 years, 1254 neu/ml in subjects aged 75-79 years and 1132 neu/ml in subjects aged 80-85 years. The corresponding GBS values for subjects in the 200 μg C. difficile antigens group were 1690 u/mL in subjects aged 65-69 years, 1073 u/mL in subjects aged 70-74 years, 1627 u/mL in subjects at the age of 75-79 years and 925 units of neutralization/ml in subjects aged 80-85 years.

On a monthly regimen in month 7, the SGD values of toxin B-specific neutralizing antibodies in subjects in the 100 μg C. difficile antigens administration group were 7608 neu/ml in subjects aged 65-69 years, 5688 neu/ml in subjects in age 70-74 years, 5446 neu/ml in subjects aged 75-79 years and 4178 neu/ml in subjects aged 80-85 years. Corresponding BGK values for subjects in the 200 μg C. difficile antigens group were 11835 neu/ml in subjects aged 65-69 years, 8750 neu/ml in subjects aged 70-74 years, 10533 neu/ml in subjects at the age of 75-79 years and 2608 units of neutralization/ml in subjects aged 80-85 years.

On a monthly regimen in month 7, the relative numbers of initially sero-negative subjects in the 100 µg C. difficile antigens group who achieved both toxin A and toxin B specific neutralizing antibody titers ≥ the established thresholds were 73, 9% of 46 subjects aged 65-69, 64.1% of 39 subjects aged 70-74, 67.9% of 28 subjects aged 75-79, and 62.5% of 8 subjects aged 80 -85 years old. The corresponding relative numbers of subjects in the 200 µg C. difficile antigens group were 91.3% of 46 subjects aged 65-69 years, 81.1% of 37 subjects aged 70-74 years, 86.4% of 22 subjects in aged 75-79 years and 55.6% of 9 subjects aged 80-85 years.

On a monthly regimen in month 7, the relative numbers of initially seropositive subjects in the 100 µg C. difficile antigens group who achieved both toxin A and toxin B specific neutralizing antibody titers ≥ the established thresholds were 100, 0% of 2 subjects aged 65-69 years, 100.0% of 1 subject aged 70-74 years, evaluation was not possible in subjects aged 75-79 years and evaluation was not possible in subjects aged 80-85 years. Corresponding relative numbers of subjects in the 200 μg C. difficile antigens group were 66.7% of 3 subjects aged 65-69 years, 100.0% of 2 subjects aged 70-74 years, and could not be estimated in subjects aged 75 -79 years and evaluation was not possible in subjects aged 80-85 years.

On a monthly regimen in month 7, the relative numbers of initially sero-negative subjects in the 100 µg C. difficile antigens group who achieved both toxin A and toxin B specific neutralizing antibody titers ≥ the established thresholds were 73, 9% of 46 subjects aged 65-69, 64.1% of 39 subjects aged 70-74, 67.9% of 28 subjects aged 75-79, and 62.5% of 8 subjects aged 80 -85 years old. The corresponding relative numbers of subjects in the 200 µg C. difficile antigens group were 91.3% of 46 subjects aged 65-69 years, 81.1% of 37 subjects aged 70-74 years, 86.4% of 22 subjects in aged 75-79 years and 55.6% of 9 subjects aged 80-85 years.

On a monthly regimen in month 7, the relative numbers of initially seropositive subjects in the 100 µg C. difficile antigens group who achieved both toxin A and toxin B specific neutralizing antibody titers ≥ the established thresholds were 100, 0% of 2 subjects aged 65-69 years, 100.0% of 1 subject aged 70-74 years, evaluation was not possible in subjects aged 75-79 years and evaluation was not possible in subjects aged 80-85 years. Corresponding relative numbers of subjects in the 200 μg C. difficile antigens group were 66.7% of 3 subjects aged 65-69 years, 100.0% of 2 subjects aged 70-74 years, and could not be estimated in subjects aged 75 -79 years and evaluation was not possible in subjects aged 80-85 years.

On a monthly regimen in month 7, the relative numbers of initially sero-negative subjects in the 100 μg C. difficile antigens group who achieved a ≥4-fold increase from baseline in both toxin A and toxin B specific neutralizing antibody titers ≥ established thresholds were 84.8% of 46 subjects aged 65-69 years, 87.2% of 39 subjects aged 70-74 years, 78.6% of 28 subjects aged 75-79 years and 100, 0% of 8 subjects aged 80-85 years. The corresponding relative numbers of subjects in the 200 µg C. difficile antigens group were 91.3% of 46 subjects aged 65-69 years, 81.1% of 37 subjects aged 70-74 years, 100.0% of 22 subjects in aged 75-79 years and 77.8% of 9 subjects aged 80-85 years.

On a monthly regimen in month 7, the relative numbers of initially seropositive subjects in the 100 µg C. difficile antigens group who achieved a ≥4-fold increase from baseline in both toxin A and toxin B specific neutralizing antibody titers ≥ thresholds were 100.0% of 2 subjects aged 65-69 years, 100% of 1 subject aged 70-74 years, assessment was not possible in subjects aged 75-79 years and assessment was not possible in subjects aged 75-79 years aged 80-85 years. Corresponding relative numbers of subjects in the 200 µg C. difficile antigens group were 66.7% of 3 subjects aged 65-69 years, 50.0% of 2 subjects aged 70-74 years, and could not be estimated in subjects aged 75 -79 years and evaluation was not possible in subjects aged 80-85 years.

On a day-to-day schedule of 37, the relative numbers of subjects in the 100 µg C. difficile antigens group achieving both toxin A and toxin B specific neutralizing antibody titers ≥ the established thresholds were 23.0% of 74 subjects aged 65-69, 30.2% of 53 subjects aged 70-74, 28.6% of 28 subjects aged 75-79, and 25.0% of 16 subjects aged 80-85 years. The corresponding relative numbers of subjects in the 200 µg C. difficile antigens group were 38.0% of 71 subjects aged 65-69 years, 30.0% of 50 subjects aged 70-74 years, 48.3% of 29 subjects in aged 75-79 years and 53.3% of 15 subjects aged 80-85 years.

On a daily schedule on Day 37, the GAM values of toxin A-specific neutralizing antibodies in subjects in the 100 μg C. difficile antigens administration group were 422 neu/ml in subjects aged 65-69 years, 389 neu/ml in subjects in age 70-74 years, 282 u/ml in subjects aged 75-79 years and 262 u/ml in subjects aged 80-85 years. The corresponding GBS values for subjects in the 200 μg C. difficile antigens group were 569 u/mL in subjects aged 65-69 years, 558 u/mL in subjects aged 70-74 years, 496 u/mL in subjects at the age of 75-79 years and 616 neutralization units/ml in subjects aged 80-85 years.

On a daily dosing schedule on day 37, the SGD values of toxin B-specific neutralizing antibodies in subjects in the 100 µg C. difficile antigens administration group were 653 neu/ml in subjects aged 65-69 years, 809 neu/ml in subjects in age 70-74 years, 566 u/ml in subjects aged 75-79 years and 1309 u/ml in subjects aged 80-85 years. The corresponding BGK values for subjects in the 200 μg C. difficile antigens group were 1192 u/mL in subjects aged 65-69 years, 805 u/mL in subjects aged 70-74 years, 2404 u/mL in subjects at the age of 75-79 years and 1449 units of neutralization/ml in subjects aged 80-85 years.

On a day-to-day schedule of 37, the relative numbers of initially sero-negative subjects in the 100 μg C. difficile antigens group that achieved both toxin A and toxin B specific neutralizing antibody titers ≥ the established thresholds were 11, 9% of 59 subjects aged 65-69, 13.2% of 38 subjects aged 70-74, 9.1% of 22 subjects aged 75-79, and 9.1% of 11 subjects aged 80 -85 years old. The corresponding relative numbers of subjects in the 200 µg C. difficile antigens group were 22.4% of 49 subjects aged 65-69 years, 21.1% of 38 subjects aged 70-74 years, 36.4% of 22 subjects in aged 75-79 years and 46.2% of 13 subjects aged 80-85 years.

On a day-to-day schedule of 37, the relative numbers of initially seropositive subjects in the 100 µg C. difficile antigens group that achieved both toxin A and toxin B specific neutralizing antibody titers ≥ the established thresholds were 100, 0% of 2 subjects aged 65-69 years, 50.0% of 2 subjects aged 70-74 years, evaluation was not possible in subjects aged 75-79 years and evaluation was not possible in subjects aged 80-85 years. Corresponding relative numbers of subjects in the 200 μg C. difficile antigens group were 100.0% of 3 subjects aged 65-69 years, 100.0% of 3 subjects aged 70-74 years, and could not be estimated in subjects aged 75 -79 years and evaluation was not possible in subjects aged 80-85 years.

On a day-to-day schedule of 37, the relative numbers of initially sero-negative subjects in the 100 μg C. difficile antigens group that achieved both toxin A and toxin B specific neutralizing antibody titers ≥ the established thresholds were 11, 9% of 59 subjects aged 65-69, 13.2% of 38 subjects aged 70-74, 9.1% of 22 subjects aged 75-79, and 9.1% of 11 subjects aged 80 -85 years old. The corresponding relative numbers of subjects in the 200 µg C. difficile antigens group were 22.4% of 49 subjects aged 65-69 years, 21.1% of 38 subjects aged 70-74 years, 36.4% of 22 subjects in aged 75-79 years and 46.2% of 13 subjects aged 80-85 years.

On a day-to-day schedule of 37, the relative numbers of initially seropositive subjects in the 100 µg C. difficile antigens group that achieved both toxin A and toxin B specific neutralizing antibody titers ≥ the established thresholds were 100, 0% of 2 subjects aged 65-69 years, 50.0% of 2 subjects aged 70-74 years, evaluation was not possible in subjects aged 75-79 years and evaluation was not possible in subjects aged 80-85 years. Corresponding relative numbers of subjects in the 200 μg C. difficile antigens group were 100.0% of 3 subjects aged 65-69 years, 100.0% of 3 subjects aged 70-74 years, and could not be estimated in subjects aged 75 -79 years and evaluation was not possible in subjects aged 80-85 years.

On a day-to-day schedule of 37 relative numbers of baseline sero-negative subjects in the 100 µg C. difficile antigens group who achieved a ≥4-fold increase from baseline in both toxin A and toxin B specific neutralizing antibody titers ≥ established thresholds were 15.3% of 59 subjects aged 65-69 years, 18.4% of 38 subjects aged 70-74 years, 18.2% of 22 subjects aged 75-79 years and 18, 2% of 11 subjects aged 80-85 years. The corresponding relative numbers of subjects in the 200 μg C. difficile antigens group were 24.5% of 49 subjects aged 65-69 years, 26.3% of 38 subjects aged 70-74 years, 36.4% of 22 subjects in aged 75-79 years and 46.2% of 13 subjects aged 80-85 years.

On a day-to-day schedule of 37, the relative numbers of baseline seropositive subjects in the 100 μg C. difficile antigens group who achieved a ≥4-fold increase from baseline in both toxin A and toxin B specific neutralizing antibody titers ≥ thresholds were 100.0% of 2 subjects aged 65-69 years, 50.0% of 2 subjects aged 70-74 years, assessment was not possible in subjects aged 75-79 years and assessment was not possible in subjects aged 80-85 years. Corresponding relative numbers of subjects in the 200 μg C. difficile antigens group were 33.3% of 3 subjects aged 65-69 years, 0.0% of 3 subjects aged 70-74 years, and could not be estimated in subjects aged 75 -79 years and evaluation was not possible in subjects aged 80-85 years.

Example 8: Placebo-Controlled, Randomized, Phase 2, Observer-Blanked Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Vaccine Against Clostridium difficile with two regimens of 3 doses to healthy adults aged 65-85 years, lasting up to 12 months after dose 3.

Clostridium difficile ( C. difficile ) is the leading cause of hospital-acquired diarrhea associated with antibiotics. To date, there is no vaccine to prevent C. difficile infection (CDI). In this phase 2 study, the inventors studied the safety, tolerability, and immunogenicity of a toxoid-based C. difficile vaccine in 855 healthy, immunocompetent adults aged 65-85 years in the United States.

Methods. The original scheduled phase of this trial ran from July 16, 2015 to March 7, 2017. Subjects were enrolled in the study and randomized to receive antigens at one of two dose levels (100 µg or 200 µg) or placebo, and one of the two 3-dose regimens: on days 1, 8 and 30 (daily regimen) or in months 0, 1 and 6 (monthly regimen). Immunogenicity testing was performed on blood samples collected during each of the nine visits during the study. Local and systemic reactogenicity was determined after each vaccination. Non-serious adverse events (AEs) were recorded up to 1 month after dose 3. Serious adverse events (SAEs) were recorded up to 6 months after dose 3. 855 healthy immunocompetent subjects were enrolled and randomized in parallel in a ratio of 3 :3:1 to receive 3 doses of C. difficile vaccine (100 mcg or 200 mcg total toxoids) or placebo (saline) on 1 of 2 dosing regimens: on days 1, 8 and 30 (daily dosing regimen) or in months 0, 1 and 6 (monthly dosing regimen). Immunogenicity testing was performed on blood samples collected during each of the 9 visits during the study: on days 1, 8, 15, 30, 37, months 2, 4, 7 and 13 on a daily regimen; and on days 1, 30, 37, 187, months 2, 6, 7, 12 and 18 in a monthly regimen. Toxin A and toxin B specific neutralizing immunoglobulin G (IgG) concentrations (neutralization units/mL) were measured at each scheduled visit during the study. For antibodies to toxin A and toxin B, geometric mean concentrations (GMEs) were calculated and thresholds for neutralization were set ( FIG. 2A, FIG. 2B, FIG. 2C, and FIG. 2D ). Local reactions and systemic events were recorded using an electronic diary for 14 days after each vaccination (7 days after dose 1 on a daily regimen). Adverse events were recorded from the moment of signing the informed consent and up to 1 month after dose 3. Serious adverse events (SAEs) were recorded up to 6 months after dose 3. Descriptive analyzes of safety, reactogenicity and immunogenicity were performed at each vaccination regimen for doses antigens (100 µg and 200 µg) and placebo.

Results. Overall, immunogenicity was higher in the 200 µg dosing group in the monthly dosing regimen after 3 doses. An increase in local reactogenicity was observed after dose No. 2 in the daily dosing regimen. The rate of adverse events in the monthly regimen was numerically higher than in the daily regimen due to the additional 5-month follow-up period.

A peak immune response to vaccination in the form of antibody production was observed at month 7 and day 37 after dose 3 for the monthly and daily regimens, respectively - ( FIG. 2A, FIG. 2B, FIG. 2C and FIG. 2D ).

At 12 months after dose 3, the monthly regimen showed a higher relative number of subjects with titers exceeding predetermined neutralization thresholds compared to the daily regimen, regardless of dose group - ( FIG. 1A, FIG. 1B, FIG 1C and FIG 1D ).

At 12 months post-dose 3, geometric mean concentrations (GAMs) of antibodies in the monthly regimen were higher compared to GAMs in the daily regimen for toxin B (4-fold excess) and toxin A (2-fold excess) - ( FIG. 2A, FIG. 2B, FIG. 2C and FIG. 2D ).

Twelve months after dose 3, anti-toxin A antibody GCR values remained above the neutralization threshold in the 200 μg monthly regimen - ( FIG. 2A and FIG. 2B ).

Anti-toxin B GFR values were above the neutralization threshold in the 200 μg monthly regimen group for approximately 9 months after the 3-dose ( FIG. 2A and FIG. 2B ).

Pain was the most frequently reported local reaction; the incidence of redness and swelling was <10% after each dose in both modes of administration.

No grade 4 local or systemic reactogenic events were noted during the study.

In the introduction regimen by month, there was no significant difference in the cumulative number of adverse events between the groups of introduction of doses and placebo - ( FIG. 3A and FIG. 3B ).

There were no serious adverse events (SAEs) associated with C difficile vaccination throughout the trial in all administration regimens and in all dosing groups - ( FIG. 3A and FIG. 3B ).

Conclusions.The monthly regimen is more immunogenic than the daily regimen after 3 doses of vaccine againstC difficile. Increased local reactogenicity was observed after dose 2 administered on day 8, in particular at the 200 μg dose level. Drug-related adverse events, serious adverse events, and discontinuations due to adverse events were higher in numerical terms in the active vaccine groups, but there were no clear patterns that could indicate safety problems. In general, the frequency and nature of adverse events were characteristic of this age group in all segments of the population. Vaccine againstC. difficile was immunogenic and well tolerated. Vaccine candidate fromClostridium difficileis highly immunogenic, well tolerated and has an acceptable safety profile. The monthly dose regimen of 200 mcg was generally more immunogenic and was chosen for the design of the phase 3 study.

The 200 μg dose level was consistently more immunogenic than the 100 μg dose level. The daily regimen results in a better early immune response at day 37/month 2 for toxin A, but not for toxin B. See, for example, FIG. 4A, FIG. 4B, FIG. 5A and FIG. 5B . In the case of toxin A, baseline seropositivity contributes to the intensity of the early immune response (particularly at the 100 μg dose level), but the difference was very small in both regimens after dose 3. In the case of toxin B in initially sero-negative subjects (~80% of the total), only the 3rd dose administered at month 6 resulted in a significant relative number of subjects in which thresholds were reached. See, for example, FIG. 6A, FIG. 6B, FIG. 7A and FIG. 7B . For all systemic events, there were no significant differences between the placebo and C. difficile vaccine groups, or between the 100 µg and 200 µg dose levels. Drug-related adverse events, serious adverse events, and discontinuations due to adverse events were higher in numerical terms in the active vaccine groups, but there were no clear patterns that could indicate safety problems. The dose level of 200 mcg administered at months 0, 1 and 6 was selected for the phase 3 study.

In terms of outcomes at month 12 after dose 3, at 12 months after dose #3, approximately 50% of subjects had scores above predetermined thresholds in both dose groups for toxin A neutralization. In the monthly regimen in the 200 mcg dose group Geometric Mean Concentration Values (GMCs) exceeded Toxin A Neutralization Thresholds 12 months after Dose #3. monthly introductions. SGK values in seropositive subjects exceeded the threshold values for neutralization of toxin B in both modes of administration. With respect to the monthly regimen, for toxin B, GBS values exceeded the thresholds for neutralization at 6 months after dose #3 (2993 neutralization units/ml) and remained similar (2178 neutralization units/ml) at 12 months after dose #3. See, for example, FIG. 1A-D, FIG. 2A-D , FIG. 8A, FIG. 8B and FIG. 9A and FIG. 9B .

Example 9: A Placebo-Controlled, Randomized, Phase 1, Observer-Blanked Trial to Evaluate the Safety, Tolerability, and Immunogenicity of a Vaccine Against Clostridium difficile with two 3-dose regimens for healthy Japanese adults aged 65-85 years (B5091010)

A placebo-controlled, randomized, phase 1, observer-blinded study was conducted to evaluate the safety, tolerability, and immunogenicity of the aluminum hydroxide-containing vaccine at 2 antigen dose levels (i.e., 100-µg and 200-µg) in 2 different dosing regimens. (months 0, 1 and 6 [monthly regimen] or days 1, 8 and 30 [daily regimen]) to healthy Japanese adults aged 65-85 years.

The study included a total of 128 healthy Japanese aged 65-85 years. Subjects were randomized in a 3:3:2 ratio to receive C difficile vaccine (toxoid total doses of 100 μg or 200 μg) or placebo (saline) in each dosing regimen.

Subjects were followed up for 6 months after confirmation of their last vaccination. Thus, subjects assigned to the monthly administration regimen participated for about 12 months, and subjects assigned to the daily administration regimen and completed it participated for approximately 7 months. This study was scheduled for completion in about 14 months. The end of the study was the last visit of the last subject.

The C difficile vaccine has not been previously studied in Japanese subjects. Therefore, the design of this first Japanese study B5091010 was similar to that of study B5091009 to evaluate the safety, tolerability and immunogenicity of an aluminum hydroxide-containing C difficile vaccine at 2 antigen dose levels (100 µg and 200 µg total toxoid doses) in two 3 dose regimens. (either on days 1, 8 and 30 or months 0, 1 and 6) to healthy Japanese aged 65-85.

During the development of study B5091010, the results of Phase 2 study B5091009 were analyzed and showed that both regimens and both dose levels were generally well tolerated. Local reactions were predominantly mild to moderate, with the most common manifestations being pain at the injection site. After dose 2, local reactogenicity was higher when the vaccine was administered on day 8 than when administered at month 1, especially at the 200 μg dose level. Systemic events were also predominantly mild to moderate, and the frequency of individual events was similar in the placebo group, the 100 µg dose group, and the 200 µg dose group. In each regimen, overall, the incidence of adverse events (AEs) was also similar in the placebo, 100 mcg and 200 mcg dose groups. In both regimens, there were more serious adverse events (SAEs) in numerical terms in the 100 mcg and 200 mcg dose groups than in the placebo group. However, there was no pattern for these phenomena and no safety issues were identified. Both dose levels studied resulted in significant neutralizing antibody titers against toxins A and B, with a preferred immunogenicity profile after 3 doses administered at months 0, 1, and 6. In addition, the 200 μg dose level was more immunogenic than the 100 μg dose level. Based on this, it was decided to move on to designing a phase 3 study using the 200 mcg dose level administered at months 0, 1, and 6.

For each dosing regimen, subjects were randomized to 1 of the 3 study arms shown in Table 4. Approximately 24 subjects were scheduled to receive C difficile vaccine at either 100 or 200 mcg toxoid dose levels, and approximately 16 subjects were to receive a placebo (saline solution).

Table 4. Vaccination groups and planned number of subjects per group and per dosing regimen Vaccine group Description of the vaccine preparation Dosing regimen Number of subjects one Aluminum hydroxide-containing C. difficile vaccine (100 mcg dose of antigens) Months 0, 1, 6 24 2 Aluminum hydroxide-containing C. difficile vaccine (200 mcg dose of antigens) Months 0, 1, 6 24 3 Placebo (saline solution) Months 0, 1, 6 16 four Aluminum hydroxide-containing C. difficile vaccine (100 mcg dose of antigens) Days 1, 8, 30 24 5 Aluminum hydroxide-containing C. difficile vaccine (200 mcg dose of antigens) Days 1, 8, 30 24 6 Placebo (saline solution) Days 1, 8, 30 16 Total 128

Serum samples were collected for immunogenicity testing. For the monthly regimen, Day 1 (before vaccine), Day 15 (14 days after dose 1), Day 30 (immediately before dose 2), Day 37 (7 days after dose 2), Monthly 2 (1 month after dose 2), at month 6 (immediately before dose 3), on day 187 (7 days after dose 3), at month 7 (1 month after dose 3), and at month 12 (at 6 months after dose 3).

For the daily regimen on Day 1 (prior to vaccine administration), Day 8 (immediately before dose 2), Day 15 (7 days after dose 2), Day 30 (immediately before dose 3), Day 37 ( 7 days after dose 3), month 2 (1 month after dose 3), month 4 (3 months after dose 3), and month 7 (6 months after dose 3).

Levels of specific for both toxin A and toxin B, neutralizing antibodies were measured.

Geometric Mean Concentrations of Toxin A and Toxin B Specific Neutralizing Antibodies - For the monthly regimen, month 7 (1 month after dose 3) was identified as the primary time point as these values reflected the immune response after the third dose of vaccine. Overall, toxin A and toxin B-specific neutralizing antibody values increased after dose 2, but peaked after dose 3 (at month 7) in both the 100 and 200 µg dose groups. Toxin A and toxin B specific neutralizing antibody SGD values were higher in the 200 µg dose group than in the 100 µg dose group at month 7. Toxin A and toxin B specific neutralizing antibody SGD values decreased from month 7 to month 12 at both dose levels. At month 12, GBS values remained above the thresholds for both toxin A and toxin B specific neutralizing antibodies in the 200 μg dose group, as well as for toxin A specific neutralizing antibodies in the 100 μg dose group. Toxin A-specific SGD values in the 200 µg dose group increased after dose 2 (on day 37) to 347.17 neu/ml and to 125.46 neu/ml in the 100 µg dose group on day 37. for toxin A neutralizing antibodies in both the 100 and 200 µg dose groups decreased by month 6 (prior to dose 3) to 88.89 neu/ml and 148.44 neu/ml, respectively. After dose 3, toxin A-specific neutralizing antibody SGD values increased again in both dose groups of 100 and 200 mcg, and at month 7 were numerically higher in the 200 mcg dose group (1692.38 neu/mL) than in the dose group 100 μg (1137.50 neu/mL). SGD values of toxin A-specific neutralizing antibodies then decreased up to month 12 (6 months after dose 3), although in both the 100 and 200 µg dose groups remained generally high (248.97 neu/mL and 587.46 neu/mL, respectively) compared with SGD values at month 6. SGD values of toxin B-specific neutralizing antibodies in both dose groups of 100 and 200 µg increased after dose 2 (on day 37) to 337.54 neu/mL and 901.16 neutralization units/ml, respectively. SGK values of toxin B-specific neutralizing antibodies decreased by month 6 (before dose 3) to 274.13 neu/ml and 689.74 neu/ml, respectively. After dose 3 (on day 187), toxin B-specific neutralizing antibody SGD values increased again in both the 100 and 200 µg dose groups, and at month 7 toxin B-specific neutralizing antibody SGD values were numerically higher in the 200 µg dose group ( 13756.54 neu/ml) than in the 100 µg dose group (7903.68 neu/ml). At month 12, toxin B-specific neutralizing antibody values decreased but remained generally high in the 200 mcg dose group (6298.18 neu/mL) but not in the 100 mcg dose group (1887.24 neu/mL). ), compared with SGD values at month 6. SGD values of toxin A-specific and toxin B-specific neutralizing antibodies remained unchanged from baseline to month 12 in the placebo group. In the monthly regimen, the SGK values of toxin A-specific and toxin-B specific neutralizing antibodies were largely similar in subjects aged 65-69 years and 70-74 years in the immunogenicity population.

In the monthly regimen, the geometric mean fold increase (GMEF) of toxin A and toxin B specific neutralizing antibody titers from baseline was calculated at each available time point after the start of the study: day 15 (14 days after dose 1), day 30 (immediately before dose 2), on day 37 (7 days after dose 2), in month 2 (1 month after dose 2), in month 6 (immediately before dose 3), on day 187 (7 days after dose 3), at month 7 (1 month after dose 3, main time point) and at month 12 (6 months after dose 3).

An increase in FMC values for toxin A-specific neutralizing antibodies was observed in the 200 µg dose group after dose 2 (at day 37; 4.26), but decreased to 1.82 by month 6. After dose 3, there was an additional increase in FMC values for specific for toxin A neutralizing antibodies in both dose groups of 100 and 200 mcg on day 187 (7.42 and 16.07, respectively) and a further increase at month 7 (12.58 and 20.77, respectively). By month 12, the SGCT values for toxin A-specific neutralizing antibodies decreased to 2.70 and 7.20 in the 100 and 200 μg dose groups, respectively. The FGC values for toxin A-specific neutralizing antibodies in the 200 µg dose group were consistently higher than those in the 100 µg dose group at each blood sampling time point. SGCT values for toxin A-specific neutralizing antibodies remained unchanged in the placebo group throughout the study.

An increase in FMC values for toxin B-specific neutralizing antibodies was observed in the 100 and 200 µg dose groups after dose 1 (at day 15; 2.81 and 5.21, respectively) and dose 2 (at day 37; 2.53 and 5, respectively). 35, respectively), with a slight decrease observed in month 6 (2.06 and 4.10, respectively). An additional increase in GMCC values for toxin B-specific neutralizing antibodies was observed after dose 3 in both dose groups of 100 and 200 mcg on day 187 (32.00 and 54.81, respectively) and a further increase at month 7 (59.28 and 81. 71, respectively). By month 12, the SGCT values for toxin B-specific neutralizing antibodies decreased to 14.01 and 36.90 in the 100 and 200 μg dose groups, respectively. The FGC values for toxin B-specific neutralizing antibodies in the 200 μg dose group were consistently higher than those in the 100 μg dose group at each blood sampling time point. SGCT values for toxin B-specific neutralizing antibodies remained unchanged in the placebo group throughout the study.

Relative numbers of subjects on a monthly regimen that achieved levels of specific toxin A, toxin B, and both toxin A and toxin B neutralizing antibodies above established thresholds (219 neu/mL [toxin A] and 2586 u/mL [toxin B]) were evaluated in a population to assess immunogenicity.

In general, the relative numbers of subjects that achieved levels of toxin A-specific and toxin B-specific neutralizing antibodies above cut-offs were higher in the 200 μg dose group than in the 100 μg dose group at all blood sampling time points. In both dose groups, the relative numbers of subjects with toxin A-specific, toxin B, and both toxin A and toxin B neutralizing antibody levels above thresholds increased after dose 2 and peaked after dose 3 (at month 7) .

In the case of toxin A-specific neutralizing antibodies, after dose 3 (on day 187), 78.3% (18/23, 95% CI: 56.3, 92.5) of subjects in the 100 mcg dose group and 95 7% (22/23, 95% CI: 78.1, 99.9) of subjects in the 200 µg dose group achieved levels of toxin A-specific neutralizing antibodies above the threshold compared to no such subjects in the placebo group. At month 7, 91.3% (21/23, 95% CI: 72.0, 98.9) of subjects in the 100 mcg dose group and 100.0% (23/23, 95% CI: 85.2, 100.0) subjects in the 200 μg dose group achieved levels of toxin A-specific neutralizing antibodies above the threshold compared to no such subjects in the placebo group. The relative numbers of subjects with toxin A-specific neutralizing antibody levels above the threshold remained high at month 12 in the 200 mcg dose group (95.5% [21/22] of subjects, 95% CI: 77.2, 99.9) but decreased in the 100 mcg dose group (55.0% [9/20] of subjects, 95% CI: 31.5, 76.9). None of the subjects in the placebo group had toxin A-specific neutralizing antibody levels above the threshold at month 12.

In the case of toxin B-specific neutralizing antibodies, after dose 3 (on day 187), 52.2% (12/23, 95% CI: 30.6, 73.2) of subjects in the 100 mcg dose group and 91 3% (21/23, 95% CI: 72.0, 98.9) of subjects in the 200 µg dose group achieved levels of toxin B-specific neutralizing antibodies above the threshold compared to no such subjects in the placebo group. At month 7, 91.3% (21/23, 95% CI: 72.0, 98.9) of subjects in the 100 mcg dose group and 100.0% (23/23, 95% CI: 85.2, 100.0) subjects in the 200 μg dose group achieved levels of toxin B-specific neutralizing antibodies above the threshold compared to no such subjects in the placebo group. The relative numbers of subjects with toxin B-specific neutralizing antibody levels above the threshold remained high at month 12 in the 200 mcg dose group (81.8% [18/22] of subjects, 95% CI: 59.7, 94.8) but decreased in the 100 mcg dose group (45.0% [11/20] of subjects, 95% CI: 23.1, 68.5). None of the subjects in the placebo group had toxin B-specific neutralizing antibody levels above the threshold at month 12.

In the monthly regimen, the relative numbers of subjects who achieved the established fold increase values (≥4 times, ≥8 times, ≥16 times, and ≥32 times) from baseline levels specific for toxin A, toxin B, and both for toxin A, and for toxin B, neutralizing antibodies were evaluated in the population to assess immunogenicity. Overall, a greater relative number of subjects who achieved the established fold increase from baseline levels of toxin A-specific neutralizing antibodies were observed in the 200 μg dose group compared to the 100 μg dose group. An increase in the relative number of subjects achieving ≥32-fold increase from baseline in both the 100 and 200 μg dose groups was observed after dose 3 (on day 187). By month 7, 69.6% (16/23) of subjects in the 100 mcg dose group and 91.3% (21/23) of subjects in the 200 mcg dose group achieved ≥8-fold increases from baseline levels. In addition, at month 7, 69.6% (16/23) of subjects in the 200 mcg dose group also achieved ≥16-fold increases from baseline levels. The fold increase from baseline levels of toxin A-specific neutralizing antibodies in the placebo group remained unchanged at all time points. The relative numbers of subjects who achieved the established fold increase from baseline levels of toxin A-specific neutralizing antibodies decreased at month 12 compared to month 7, with 5.0% (1/20) of subjects in the 100 µg dose group and 13 .6% (3/22) of subjects in the 200 mcg dose group who achieved ≥16-fold increase from baseline levels.

In general, a greater relative number of subjects who achieved established fold increase from baseline levels of toxin B-specific neutralizing antibodies were observed in the 200 μg dose group compared to the 100 μg dose group. An increase in the relative number of subjects who achieved a ≥32-fold increase from baseline in both the 100 and 200 μg dose groups was observed after dose 3 (on day 187). By month 7, 73.9% (17/23) of subjects in the 100 mcg dose group and 82.6% (19/23) of subjects in the 200 mcg dose group achieved ≥32-fold increases from baseline. The fold increase from baseline levels of toxin B-specific neutralizing antibodies in the placebo group remained unchanged at all time points. The relative numbers of subjects who achieved the established fold increase from baseline levels of toxin B-specific neutralizing antibodies decreased at month 12 compared to month 7, with 25.0% (5/20) of subjects in the 100 µg dose group and 45 .5% (10/22) of subjects in the 200 mcg dose group who achieved ≥32-fold increases from baseline.

An increase in the relative numbers of subjects that achieved a ≥8-fold increase from baseline in both toxin A and toxin B specific neutralizing antibodies in both the 100 and 200 μg dose groups was observed after dose 3 (at day 187). By month 7, 69.6% (16/23) of subjects in the 100 mcg dose group and 87.0% (20/23) of subjects in the 200 mcg dose group achieved ≥8-fold increases from baseline levels. In addition, at month 7, 65.2% (15/23) of subjects in the 200 mcg dose group achieved ≥16-fold increases from baseline levels. The fold increase from baseline levels of both toxin A and toxin B specific neutralizing antibodies in the placebo group remained unchanged at all time points.

The relative numbers of subjects with toxin-specific A and B neutralizing antibody levels ≦LLQV on a monthly regimen were assessed. Overall, a low relative number of subjects in both the 100 and 200 mcg dose groups had toxin A-specific or toxin B neutralizing antibody levels <LFLV at month 7 and month 12. Most subjects in the placebo group had toxin A-specific levels , toxin B, as well as both toxin A and toxin B, neutralizing antibodies < LFLV at all time points.

In the monthly regimen, day 37 (7 days after dose 3) was identified as the main time point because these values reflected the immune response after the third vaccine dose; however, due to the limited number of subjects enrolled in the study as a result of the decision to discontinue subsequent dosing under the study withdrawal rule, no conclusions could be drawn at day 30 and beyond. Toxin A-specific neutralizing antibody SGD values in the 100 and 200 µg dose groups increased after dose 1 and dose 2, but more so in the 200 µg dose group on day 15 (515.67 neu/mL) and day 30 (673 .00 u/ml) than in the 100 mcg dose group (79.00 u/ml on day 15 and 116.21 u/ml on day 30). Toxin A-specific neutralizing antibody GCR values remained unchanged throughout the study in the placebo group. Similar to toxin A, toxin B-specific neutralizing antibody MHC values in the 100 and 200 µg dose groups increased after dose 1 and dose 2, but more so in the 200 µg dose group on day 15 (3531.69 neu/mL) and on day 30 (4666.51 neu/ml) than in the 100 mcg dose group (692.98 neu/ml and 682.09 neu/ml). SGK values of toxin B-specific neutralizing antibodies remained unchanged throughout the study in the placebo group.

In the daily regimen, the MCC values for toxin A-specific and toxin B-specific neutralizing antibodies from baseline were calculated at each available time point after the start of the study: on day 8 (immediately before dose 2), on day 15 (7 days after dose 2), day 30 (immediately before dose 3), day 37 (7 days after dose 3, main time point), month 2 (1 month after dose 3), month 4 (3 months after dose 3) and at month 7 (6 months after dose 3). Due to the limited number of subjects caused by the decision to discontinue subsequent dosing under the study withdrawal rule, no conclusions could be drawn at day 30 and beyond. An increase in GMCC values for toxin A-specific neutralizing antibodies was observed in the 200 μg dose group after dose 2 on day 15 (6.11) and an additional increase on day 30 (7.79). An increase in FMC values for toxin A-specific neutralizing antibodies was observed after dose 2 in the 100 µg dose group on day 30 (1.47), but was generally lower than for FMC values observed in the 200 µg dose group at all time points . SGCT values for toxin A-specific neutralizing antibodies remained unchanged in the placebo group at all time points.

An increase in FMC values for toxin B-specific neutralizing antibodies was observed in both the 100 and 200 µg dose groups after dose 1 (on day 8: 1.41 and 1.78, respectively), with a further increase seen in both dose groups on day 15 (4.37 and 9.01, respectively) and on day 30 (4.59 and 10.63, respectively). The FGC values for toxin B-specific neutralizing antibodies were consistently higher in the 200 μg dose group than those in the 100 μg dose group. SGCT values for toxin B-specific neutralizing antibodies remained unchanged in the placebo group at all time points.

In a daily regimen, the relative numbers of subjects in the modified ITT (mITT) population who achieved levels of specific toxin A, toxin B, and both toxin A and toxin B neutralizing antibodies above the established thresholds (219 units neu/mL [toxin A] and 2586 u/mL [toxin B]). By day 30 on the daily regimen, a higher percentage of subjects in the 200 mcg dose group (62.5% [5/8] of subjects, 95% CI: 24.5, 91.5) compared to the 100 dose group mcg (20.0% [1/5] of subjects, 95% CI: 0.5, 71.6), levels of toxin A-specific neutralizing antibodies above cut-offs were achieved.

Similarly, in the case of toxin B-specific neutralizing antibodies, on day 30, a higher percentage of subjects in the 200 mcg dose group (62.5% [5/8] of subjects, 95% CI: 24.5, 91.5), compared with the 100 mcg dose group (20.0% [1/5] of subjects, 95% CI: 0.5, 71.6), levels of toxin B-specific neutralizing antibodies were achieved above cut-offs.

In the case of both toxin A and toxin B specific neutralizing antibodies, half of the subjects achieved levels above cut-offs by day 30 in the 200 mcg dose group (50.0% [4/8] of subjects, 95% CI: 15.7, 84.3), with none of the subjects reaching levels above the thresholds specific for both toxin A and toxin B neutralizing antibodies in the 100 µg dose group (0.0 % [0/5] subjects).

On a daily regimen, the relative numbers of subjects who achieved target folds (≥4 times, ≥8 times, ≥16 times, and ≥32 times) from baseline levels specific for toxin A, toxin B, and both were assessed. A, and for toxin B, neutralizing antibodies. Overall, a higher relative number of subjects on a daily regimen who achieved target fold increase from baseline levels of toxin A-specific neutralizing antibodies were observed in the 200 μg dose group compared to the 100 μg dose group. None of the subjects in the 100 µg dose group achieved a ≥4-fold or greater increase in toxin A-specific neutralizing antibody levels up to day 30. There was an increase in the relative number of subjects in the 200 µg dose group who achieved ≥32-fold increase from baseline levels after dose 2 (day 15) that continued until day 30 (25.0% [2/8] of subjects in the 200 mcg dose group achieved ≥32-fold increase from baseline) . The fold increase from baseline levels of toxin A-specific neutralizing antibodies in the placebo group remained unchanged at all time points.

Similar to the situation with toxin A-specific neutralizing antibodies, a higher relative number of subjects on the daily regimen who achieved the established fold increase from baseline levels of toxin B-specific neutralizing antibodies was observed in the 200 μg dose group compared to the 100 dose group. mcg. There was an increase in the relative number of subjects who achieved ≥32-fold increases from baseline in both the 100 and 200 mcg dose groups after dose 2 (Day 15), which continued up to day 30. On day 30, only 1 of 5 subjects in the 100 μg dose group achieved any of the established fold increase values. Conversely, 62.5% [5/8] of subjects in the 200 µg dose group achieved a ≥16-fold increase at day 30. The fold increase from baseline levels of toxin B-specific neutralizing antibodies in the placebo group remained unchanged at all time points. points.

None of the subjects in the 100 μg dose group achieved a ≥4-fold or greater increase in both toxin A and toxin B specific neutralizing antibodies up to and including day 30. There was an increase in relative the number of subjects who achieved a ≥32-fold increase from baseline in toxin A and B specific antibodies in the 200 mcg dose group after dose 2 (on day 15) that continued up to day 30 (in 12.5% [ 1/8] subjects in the 200 mcg dose group achieved ≥32-fold increases from baseline levels). The fold increase from baseline toxin A-specific and toxin B-specific neutralizing antibodies in the placebo group remained unchanged at all time points.

The relative numbers of subjects with toxin A-specific and toxin B-specific neutralizing antibody levels < LRQV per day were assessed. Subjects in both the 100 and 200 mcg dose groups had toxin A-specific neutralizing antibody levels < LLOQ after dose 2 on day 15 (100.0% [11/11] of subjects and 54.5% [6/11] of subjects, respectively) , and this amount was reduced at day 30 (60.0% [3/5] of subjects and 25.0% [2/8] of subjects, respectively). By day 30, subjects in both the 100 and 200 µg dose groups had toxin B-specific neutralizing antibody levels <LFLV (40.0% [2/5] of subjects and 37.5% [3/8] of subjects, respectively) and levels of specific for both toxin A and toxin B, neutralizing antibodies < LLR (20.0% [1/5] of subjects and 12.5% [1/8] of subjects, respectively).

Conclusions . Immunogenicity endpoints were considered secondary endpoints in this study. Immunogenicity endpoints included GBC values and FCL values from baseline toxin A-specific and toxin B-specific neutralizing antibody levels, as well as the relative number of subjects with levels specific for toxin A, toxin B, or both toxin A and toxin B, neutralizing antibodies above cut-offs and the relative numbers of subjects having ≥4-fold, ≥8-fold, ≥16-fold, and ≥32-fold increases from baseline in antibody levels. As a result of the discontinuation of the study on a daily regimen, only a limited amount of immunogenicity data was available for this group after 30 days. Thus, the following conclusions were made based on the data obtained in the introduction mode by month. Overall, toxin A-specific and toxin-B specific neutralizing antibody values increased after dose 1, peaked at month 7, and decreased until month 12 in both the 100 and 200 mcg dose groups. At month 7, both toxin A and toxin B specific neutralizing antibody values were numerically higher in the 200 mcg dose group (1692.38 and 13756.54 neu/mL, respectively) than in the 100 mcg dose group. (1137.50 and 7903.68 neu/ml, respectively). By month 12, toxin A and toxin B-specific neutralizing antibody SGD values decreased, but remained high in the 200 mcg dose group (587.46 and 6298.18 neu/mL, respectively) compared to SGD values at month 6. for toxin A-specific neutralizing antibodies in the 200 µg dose group were consistently higher than those in the 100 µg dose group at each blood sampling time point. After dose 3, an increase in SGCU values from baseline was observed in both the 100 and 200 µg dose groups. Toxin A-specific and toxin B-specific neutralizing antibody values peaked at month 7 and were numerically higher in the 200 µg dose group (20.77 and 81.71, respectively) than in the 100 µg dose group (12.58 and 59.28, respectively). Thereafter, the FMU values for toxin A and toxin B specific neutralizing antibodies decreased by month 12 in both vaccination groups. The relative numbers of subjects that achieved levels of toxin A-specific and toxin B-specific neutralizing antibodies above cut-offs tended to be higher in the 200 μg dose group than in the 100 μg dose group at all blood sampling time points. By month 7, 100.0% of subjects in the 200 µg dose group achieved toxin A and toxin B-specific neutralizing antibodies above cut-off levels, with more than 90% of subjects in the 100 µg dose group achieving levels above cut-offs. values. The relative numbers of subjects who achieved levels of toxin A-specific and toxin B-specific neutralizing antibodies above cut-offs remained high at month 12 in the 200 mcg dose group (95.5% and 81.8%, respectively), but decreased in the 100 mcg dose group (55.0% and 45.0%, respectively). None of the subjects in the placebo group had levels of toxin A-specific or toxin B neutralizing antibodies above the cut-offs at month 12. In the case of toxin A-specific neutralizing antibodies, 69.6% (16/23) of the subjects in the group 100 mcg dose and 91.3% (21/23) of subjects in the 200 mcg dose group achieved ≥8-fold increase from baseline levels by month 7, with most subjects (69.6%; 16/23) at the 200 mcg dose group also achieved a ≥16-fold increase from baseline levels at month 7. The relative numbers of subjects who achieved the established fold increase from baseline levels of toxin A-specific neutralizing antibodies decreased at month 12 compared to month 7 , with 5.0% (1/20) of subjects in the 100 μg dose group and 13.6% (3/22) of subjects in the 200 μg dose group achieving ≥16-fold increases from baseline levels. In the case of toxin B-specific neutralizing antibodies, most subjects in both the 100 and 200 µg dose groups achieved ≥32-fold increases from baseline levels (73.9% [17/23] of subjects and 82.6% [19 /23] of subjects, respectively) by month 7. The relative numbers of subjects who achieved the established fold increase from baseline levels of toxin B-specific neutralizing antibodies decreased in month 12 compared to month 7, with 25.0% (5/20) of subjects in the 100 mcg dose group and 45.5% (10/22) of subjects in the 200 mcg dose group achieved ≥32-fold increases from baseline. Due to the very low number of baseline seropositive subjects on daily and monthly regimens at baseline in the 100 µg, 200 µg and placebo dose groups, it was not possible to assess the effects of baseline serostatus on GBS. As seen in the CIR for the monthly regimen, the 200 µg dose group had higher concentrations of toxin A and toxin B specific neutralizing antibodies than the 100 µg dose group at month 7 and generally at all time points. Taken together, these results indicate that, in a monthly regimen, peak immunogenicity occurs approximately 1 month after dose 3 (at month 7) of C difficile vaccine. In addition, the 200 μg dose induces a stronger and longer lasting antibody response than the 100 μg dose, as assessed by toxin A and toxin B-specific neutralizing antibodies SGK and SGK values.

Example 10 : Antibodies induced by immunogenic compositions are able to neutralize toxins from different strains of C. difficile

Culture supernatants containing various strain-secreted toxins were tested in an in vitro neutralization assay using sera from primates immunized with the immunogenic composition to determine coverage of the immunogenic composition and to determine the ability of the immunogenic composition to protect against various toxins from circulating clinical strains.

IMR-90 cells were used to test the neutralization of toxins expressed by different strains of C. difficile . The neutralization titers of the test samples were calculated based on the reference standard. LCV analysis: Txd A=158.0 U/ml; Txd B=249.5 U/ml. The results in Table 5 show that sera from immunized primates were able to neutralize C. difficile toxins from each of the respective culture supernatants in the neutralization assay.

Table 5

Description of Clostridium difficile strains: Epidemiological markers, toxin genotype, sequence identity with vaccine antigen, and ability of primate anti-toxin antibodies to neutralize toxins C. difficile strain Strain Source Type PFGE ribotype Toxinotype Toxin variant
(% identity with vaccine antigen ^a ) The ability of primate anti-toxin antibodies to neutralize C difficile toxins TcdB TcdA PFECD0003 Europe NAP6 002 0 TcdB_016 (99.7) TcdA_017 (99.7) + PFECD0005 Europe NAP10 003 I TcdB_010 (99.8) TcdA_018 (99.7) + PFECD0046 Europe NAPCR1 004 0 TcdB_001 (99.9) TcdA_006 (99.8) + PFECD0078 Europe NA 012 0 TcdB_001 (99.9) TcdA_001(99.9) + PFECD0008 Canada NAP12 015 0 TcdB_005 (99.8) TcdA_014 (99.6) + PFECD0010 USA NAP9 017 VIII TcdB_003 (93.7) short ^c + PFECD0011 Europe NAP4 020 0 TcdB_007 (99.8) TcdA_003 (99.7) + PFECD0012 Europe NA 023 IV TcdB_006 (98.1) TcdA_019 (98.3) + PFECD0013 Europe NAP1 027 III TcdB_012 (99.8) TcdA_010 (99.8) + PFECD0015 USA NAP1 027 III TcdB_002 (92.1) TcdA_007 (98.1) + PFECD0016 Europe NA 029 0 TcdB_006 (98.1) TcdA_019 (98.3) + PFECD0017 Europe NA 046 0 TcdB_008 (99.8) TcdA_004 (99.7) + PFECD0019 USA NAP3 053 0 TcdB_008 (99.8) TcdA_012 (99.7) + PFECD0021 Europe NA 059 IV TcdB_015 (99.7) TcdA_011 (99.7) + PFECD0022 Europe NA 070 XIII TcdB_016 (99.7) TcdA_017 (99.7) + PFECD0023 USA NAP10 070 0 TcdB_012 (99.8) TcdA_015 (99.8) + PFECD0024 Europe NA 075 III TcdB_012 (99.8) TcdA_010 (99.8) + PFECD0027 Europe NA 078 0 TcdB_004 (95.9) TcdA_013 (97.9) + PFECD0030 USA NAP7 078 V TcdB_004 (95.9) TcdA_013 (97.9) + PFECD0031 Europe NA 081 0 TcdB_013 (99.8) TcdA_009 (99.7) + PFECD0032 Europe NA 087 0 TcdB_001 (99.9) TcdA_009 (99.7) + PFECD0035 USA NAP11 106 0 TcdB_009 (99.8) TcdA_002(99.7) + PFECD0036 Europe NA 117 0 TcdB_001 (99.9) TcdA_005(99.9) + PFECD0037 Europe NA 126 NA TcdB_016 (99.7) TcdA_017 (99.7) + PFECD0039 Canada NAP7 126 V TcdB_011 (86.9) TcdA_016 (98.3) + PFECD0040 Europe NA 131 NA TcdB_016 (99.7) TcdA_017 (99.7) + PFECD0041 USA NAP4 154 0 TcdB_014 (99.8) TcdA_010 (99.8) + PFECD0043 USA NAP11 ^NAb 0 TcdB_008 (99.8) TcdA_008 (99.7) + PFECD0049 USA NAP2 ^NAb 0 TcdB_012 (99.8) TcdA_010 (99.8) +

Example 11: Diagnostic assays in support of a phase 3 study to study the efficacy of a vaccine against C. difficile

Clover (B5091007) is a phase 3 interstate pivotal study to evaluate the efficacy, safety, and tolerability of a toxoid-based Clostridium (C) difficile vaccine in subjects aged 50 years or older who are at increased risk of developing CDI. With the involvement of approximately 400 research centers in 23 countries, approximately 16,000 subjects will be included in this study. The main goal of this phase 3 study will be to demonstrate the effectiveness of the vaccine in reducing the frequency of the first major episodes of CDI based on both clinical and laboratory diagnostic criteria. To evaluate the effectiveness of the vaccine, it is necessary to monitor the occurrence of diarrhea in subjects, collect stool samples when this occurs, send these samples to a central laboratory under temperature controlled conditions, and test them for the presence of C difficile and the toxin(s) that cause the disease. To ensure the accuracy of laboratory diagnosis of CDI, a two-stage algorithm is used to test stool samples. This algorithm is based on the detection of C. difficile strains/spores carrying the toxin B gene by PCR, followed by the detection of free toxins (A and B) using a proprietary toxin detection test (CCNA). This approach was chosen because epidemiological studies have clearly demonstrated that free toxin detection is a better predictor of CDI disease than PCR alone. i, ii In addition, a two-stage testing algorithm has already been recommended in the EU by the European Society for Clinical Microbiology and Infectious Diseases, and in the US by the Infectious Diseases Society of America and the American Society for Health Epidemiology. The main operational/executive difficulties of conducting this study are described, as well as the qualification assessment of PCR and validation/clinical validation of CCNA. Both assays meet all specified acceptance criteria and are suitable for their intended use as diagnostic assays in determining the efficacy of a C. difficile vaccine and in epidemiological studies.

Qualification: CEPHEID XPERT Validation ^® C. difficile /epi-PCR test and CCNA clinical validation

The XPERT ^® C. difficile /epi-PCR and CCNA tests are sensitive, reliable and reproducible. The results of assay qualification and validation of reproducibility, linearity, accuracy and/or specificity confirmed that the XPERT ^® C. difficile /epi-PCR test and CCNA are suitable for their intended use. Each assay was tested using true positive and CDI negative stool specimens and evaluated for clinical accuracy. Both the ^XPERT® C. difficile /epi-PCR test and the CCNA were clinically accurate, correctly classifying positive and negative samples.

Specificity: 50 non-toxicogenic and non- C. difficile strains were evaluated by ^XPERT® C. difficile /epi-PCR. There was no cross-reactivity, which corresponds to an analytical specificity of 100%.

Sensitivity: The limit of detection (LOD) of 10 strains of C. difficile added to stool samples was determined. PO for 10 strains ranged from 344 to 2175 colony forming units (CFU).

Reproducibility: 9 received samples were tested by 2 analysts using 3 lots of testing reagents during 10 days of testing. Sample variability under these conditions was <2% relative standard deviation.

Accuracy: Consistency between measured value and reference value at 10x concentration is indicated by slope = -3.3 Ct.

Using the CEPHEID ^XPERT® C. difficile /epi-PCR test, specimens were correctly identified in 93 CDI cases in clinical validation; excellent CCNA reproducibility was observed during assay validation; CCNA demonstrated 100% clinical specificity compared to the reference method; and CCNA demonstrated 95.7% clinical sensitivity compared to another reference method.

Conclusion : A 2-step algorithm is used to confirm CDI laboratory methods based on the detection of the microorganism C. difficile , followed by the detection of toxins. Prior to use in the CLEVER study, both the ^XPERT® C. difficile /epi-PCR test and CCNA were found to be suitable and/or validated and demonstrated excellent analytical specificity, sensitivity and reproducibility. During the clinical validation process, both diagnostic assays were clinically specific and sensitive in identifying suspected cases of CDI. Each of the assays, combined with a robust clinical sampling strategy, is currently being used in a phase 3 clinical trial of a C. difficile vaccine.

The following paragraphs describe additional embodiments of the invention:

C1. A method for eliciting an immune response in a human against Clostridium difficile infection, comprising administering to a human an effective dose of a composition containing a C. difficile toxoid, wherein the composition is administered at least twice.

C2. The method according to C1, characterized in that the second administration is carried out at least 7 days after the first administration, and the third administration is carried out approximately 30 days after the first administration.

C3. The method according to p. C1, characterized in that the third administration is carried out approximately 180 days after the first administration.

C4. The method according to p. C1, characterized in that the composition is administered at least three times.

C5. The method according to claim C2, characterized in that the second administration is carried out approximately 30 days after the first administration, and the third administration is carried out approximately 180 days after the first or second administration.

C6. The method according to p. C2, characterized in that the third administration is carried out at least 180 days after the first administration.

C7. The method according to claim C1, characterized in that the immune response elicited includes a neutralizing monoclonal antibody against toxin A.

C8. The method according to claim C1, characterized in that the immune response elicited includes a neutralizing monoclonal antibody against toxin B.

C9. The method of claim C1, wherein the immune response elicited comprises a neutralizing monoclonal antibody against toxin A and a neutralizing monoclonal antibody against toxin B, wherein the concentration of the neutralizing monoclonal antibody is at least 10 μg/ml.

C10. The method of claim C1, wherein the composition comprises C. difficile toxoid A and/or C. difficile toxoid B, each of which is at least 90% or more pure.

C11. The method of claim C1, wherein the composition comprises C. difficile toxoid A and/or C. difficile toxoid B in a ratio of about 3:1 to about 1:1.

C12. The method according to claim C1, characterized in that the composition contains C. difficile toxoid A and/or C. difficile toxoid B in a ratio of 1:1.

C13. The method according to p. C1, characterized in that the composition contains an adjuvant.

C14. The method according to p. C1, characterized in that the composition contains an aluminum-based adjuvant.

C15. The method of claim C1 wherein the immune response against C. difficile toxin A and/or B toxin B is maintained for at least about 60 days.

C16. The method of claim C1 wherein the immune response against C. difficile toxin A and/or B toxin B is maintained for at least about 180 days.

C17. The method of claim C1 wherein the immune response against C. difficile toxin A and/or B toxin B is maintained for at least about 365 days.

C18. The method of claim C1 wherein the immune response against C. difficile toxin A and/or B toxin B is maintained for at least about 540 days.

C19. The method according to claim C1, characterized in that the second administration is carried out at least 7 days after the first administration, and the third administration is carried out at least 30 days after the first administration.

C20. The method according to claim C1, characterized in that the third administration is carried out at least 30 days after the first administration.

C21. The method according to claim C1, characterized in that the second administration is carried out at least 7 days after the first administration, and the third administration is carried out at least 180 days after the first or second administration.

C22. The method according to p. C1, characterized in that the third administration is carried out at least 180 days after the first administration.

C23. The method of claim C1, wherein the composition comprises C. difficile toxoid A and/or C. difficile toxoid B, each of which is at least 90% or more pure.

C24. The method of claim C1, wherein the composition comprises C. difficile toxoid A and/or C. difficile toxoid B in a ratio of about 3:1 to about 1:1.

C25. The method according to claim C1, characterized in that the composition contains C. difficile toxoid A and/or C. difficile toxoid B in a ratio of 1:1.

C26. The method according to p. C1, characterized in that the composition contains an adjuvant.

C27. The method according to p. C1, characterized in that the composition contains an aluminum-based adjuvant.

C28. The method of claim C1 wherein the immune response against C. difficile toxin A and/or B toxin B is maintained for at least about 60 days.

C29. The method of claim C1 wherein the immune response against C. difficile toxin A and/or B toxin B is maintained for at least about 180 days.

C30. The method of claim C1 wherein the immune response against C. difficile toxin A and/or B toxin B is maintained for at least about 365 days.

C31. The method of claim C1, wherein the C. difficile toxoid A is associated with an aluminum-based adjuvant.

C32. The method of claim C1, wherein the C. difficile toxoid B is associated with an aluminum-based adjuvant.

C33. The method of claim C1, wherein C. difficile toxoid A and/or C. difficile toxoid B are lyophilized.

C34. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the first dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C35. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 4-fold higher in the human after the first dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C36. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 8-fold higher in humans after the first dose than the toxin A-specific neutralizing antibody concentration in humans prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C37. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 16-fold higher in the human after the first dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C38. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 32-fold higher in humans after the first dose than the toxin A-specific neutralizing antibody concentration in humans prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C39. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the first dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C40. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 4-fold higher in the human after the first dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C41. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 8-fold higher in the human after the first dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C42. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 16-fold higher in the human after the first dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C43. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 32-fold higher in humans after the first dose than the toxin B-specific neutralizing antibody concentration in humans prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C44. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the second dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C45. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 4-fold higher in the human after the second dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C46. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 8-fold higher in the human after the second dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C47. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 16-fold higher in the human after the second dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C48. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the second dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C49. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the second dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C50. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 4-fold higher in the human after the second dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C51. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 8-fold higher in humans after the second dose than the toxin B-specific neutralizing antibody concentration in humans prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C52. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 16-fold higher in the human after the second dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C53. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the second dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C54. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the third dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C55. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 4-fold higher in the human after the third dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C56. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 8-fold higher in humans after the third dose than the toxin A-specific neutralizing antibody concentration in humans prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C57. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 16-fold higher in the human after the third dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C58. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the third dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C59. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the third dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C60. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 4-fold higher in the human after the third dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C61. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 8-fold higher in the human after the third dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C62. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 16-fold higher in humans after the third dose than the toxin B-specific neutralizing antibody concentration in humans prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C63. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the third dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose, at measurement under identical conditions in the cytotoxicity assay.

C64. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in humans after the first dose, as measured at about 7, 30, 60, 90, 120, 365 or 540 days after the first dose than the concentration of toxin A-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay.

C65. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in humans after the second dose, as measured at about 7, 30, 60, 90, 120, 365, or 540 days after the second dose than the concentration of toxin A-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay.

C66. The method of claim C1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in humans after the third dose, as measured at about 7, 30, 60, 90, 120, 365, or 540 days after the third dose than the concentration of toxin A-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay.

C67. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in humans after the first dose, as measured at about 7, 30, 60, 90, 120, 365 or 540 days after the first dose than the concentration of toxin B-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay.

C68. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in humans after the second dose, as measured at about 7, 30, 60, 90, 120, 365, or 540 days after the second dose than the concentration of toxin B-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay.

C69. The method of claim C1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in humans after the third dose, as measured on about any day of 7, 30, 60, 90, 120 , 365, or 540 days after the third dose than the concentration of toxin B-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay.

C70. The method of claim C1, wherein the composition results in a concentration of toxin B-specific neutralizing antibody in humans after the third dose, as measured on about any day of 7, 30, 60, 90, 120, 365, or 540 days after the third dose, than the concentration of toxin B-specific neutralizing antibody in humans prior to the first dose, when measured under identical conditions in the cytotoxicity assay.

C71. The method according to C1, wherein the person is seronegative for toxin B.

C72. The method according to C1, wherein the person is seronegative for toxin A.

C73. The method according to C1, wherein the person is seronegative for toxin A and toxin B.

C74. The method of C1, wherein the person is seropositive for toxin B.

C75. The method according to C1, wherein the person is seropositive for toxin A.

C76. The method according to C1, wherein the person is seropositive for toxin A and toxin B.

C77. The method of claim C1, wherein the toxoid comprises SEQ ID NO: 4, wherein no methionine residue is present.

C78. The method of claim C1, wherein the toxoid comprises SEQ ID NO: 6, in which there is no methionine residue.

C79. The method of claim C1, wherein the toxoid comprises any one of SEQ ID NOs: 1-8, 15, 17, 19, 21, 23, 25, 28-35, 82-761, in which there is no methionine residue.

C80. The method of claim C1, wherein the toxoid comprises formaldehyde-treated C. difficile toxin A.

C81. The method of claim C1, wherein the toxoid comprises formaldehyde-treated C. difficile toxin B.

C82. The method of claim C1, wherein the toxoid is not treated with formaldehyde.

C83. Method according to C1, wherein the cause of infection is C. difficile ribotype 002.

C84. Method according to C1, wherein the cause of infection is C. difficile ribotype 003.

C85. Method according to C1, wherein the cause of infection is C. difficile ribotype 004.

C86. Method according to C1, wherein the cause of infection is C. difficile ribotype 012.

C87. Method according to C1, wherein the cause of infection is C. difficile ribotype 015.

C88. Method according to C1, wherein the cause of infection is C. difficile ribotype 017.

C89. Method according to C1, wherein the cause of the infection is C. difficile ribotype 020.

C90. Method according to C1, wherein the cause of infection is C. difficile ribotype 023.

C91. Method according to C1, wherein the cause of the infection is C. difficile ribotype 027.

C92. The method of claim C1, wherein the cause of infection is C. difficile ribotype 029.

C93. Method according to C1, wherein the cause of infection is C. difficile ribotype 046.

C94. Method according to C1, wherein the cause of infection is C. difficile ribotype 053.

C95. Method according to C1, wherein the cause of infection is C. difficile ribotype 059.

C96. The method of claim C1, wherein the cause of the infection is C. difficile ribotype 070.

C97. Method according to C1, wherein the cause of the infection is C. difficile ribotype 075.

C98. Method according to C1, wherein the cause of infection is C. difficile ribotype 078.

C99. Method according to C1, wherein the cause of the infection is C. difficile ribotype 081.

C100. Method according to C1, wherein the cause of infection is C. difficile ribotype 087.

C101. Method according to C1, wherein the cause of infection is C. difficile ribotype 106.

C102. Method according to C1, wherein the cause of infection is C. difficile ribotype 117.

C103. Method according to C1, wherein the cause of infection is C. difficile ribotype 126.

C104. Method according to C1, wherein the cause of infection is C. difficile ribotype 131.

C105. Method according to C1, wherein the cause of infection is C. difficile ribotype 154.

C106. Method according to C1, wherein the cause of the infection is C. difficile toxinotype 0.

C107. Method according to C1, wherein the cause of the infection is C. difficile toxinotype I.

C108. The method of claim C1, wherein the cause of the infection is C. difficile toxinotype VIII.

C109. The method of claim C1, wherein the cause of the infection is C. difficile toxinotype IV.

C110. The method of claim C1, wherein the cause of the infection is C. difficile toxinotype III.

C111. The method according to C1, wherein the cause of the infection is C. difficile toxinotype XIII.

C112. Method according to C1, wherein the cause of the infection is C. difficile toxinotype V.

--->

SEQUENCE LIST

<110> PFIZER INC.

<120> COMPOSITIONS AND METHODS FOR PROCESSING AN IMMUNE RESPONSE

AGAINST CLOSTRIDIUM DIFFICILE

<130> PC72392

<150> 62/565096

<151> 2017-09-28

<160> 761

<170>PatentIn version 3.5

<210> 1

<211> 2709

<212> PROTEIN

<213> Clostridium difficile

<400> 1

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 2

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 2

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 3

<211> 2710

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: TcdA (mutations

D285A D287A)

<400> 3

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 4

<211> 2710

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: TcdA (mutations

D285A D287A C700A)

<400> 4

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 5

<211> 2366

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: TcdB (mutations

D286A D288A)

<400> 5

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 6

<211> 2366

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: TcdB (mutations

D286A D288A C698A)

<400> 6

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 7

<211> 2710

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: TcdA (mutations

D269A, R272A, D285A, D287A, E460A, R462A and C700A)

<400> 7

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Ala Ile Val Ala

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Ala Ala Ala Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 8

<211> 2366

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: TcdB (mutations

D270A, R273A, D286A, D288A, D461A, K463A and C698A)

<400> 8

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu

260 265 270

Ala Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Ala Val Ala Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 9

<211> 8133

<212> DNA

<213> Clostridium difficile

<400> 9

atgtctttaa tatctaaaga agagttaata aaactcgcat atagcattag accaagagaa 60

aatgagtata aaactatact aactaattta gacgaatata ataagttaac tacaaacaat 120

aatgaaaata aatatttaca attaaaaaaa ctaaatgaat caattgatgt ttttatgaat 180

aaatataaaa cttcaagcag aaatagagca ctctctaatc taaaaaaaga tatattaaaa 240

gaagtaattc ttattaaaaa ttccaataca agccctgtag aaaaaaattt acattttgta 300

tggataggtg gagaagtcag tgatattgct cttgaataca taaaacaatg ggctgatatt 360

aatgcagaat ataatattaa actgtggtat gatagtgaag cattcttagt aaatacacta 420

aaaaaggcta tagttgaatc ttctaccact gaagcattac agctactaga ggaagagatt 480

caaaatcctc aatttgataa tatgaaattt tacaaaaaaa ggatggaatt tatatatgat 540

agacaaaaaa ggtttataaa ttattataaa tctcaaatca ataaacctac agtacctaca 600

atagatgata ttataaagtc tcatctagta tctgaatata atagatga aactgtatta 660

gaatcatata gaacaaattc tttgagaaaa ataaatagta atcatgggat agatatcagg 720

gctaatagtt tgtttacaga acaagagtta ttaaatattt atagtcagga gttgttaaat 780

cgtggaaatt tagctgcagc atctgacata gtaagattat tagccctaaa aaattttggc 840

ggagtatatt tagatgttga tatgcttcca ggtattcact ctgatttatt taaaacaata 900

tctagaccta gctctattgg actagaccgt tgggaaatga taaaattaga ggctattatg 960

1020

1080

1140 aaattagaaa atttaaatgt atctgatctt gaaattaaaa

gttataaatc aagccttgat atcaaaacaa ggttcatatc ttactaacct agtaatagaa 1200

1260

aataacttca cagatactac taaaattttt catgattcat tatttaattc agctaccgca 1320

gaaaactcta tgtttttaac aaaaatagca ccatacttac aagtaggttt tatgccagaa 1380

gctcgctcca caataagttt aagtggtcca ggagcttatg cgtcagctta ctatgatttc 1440

ataaatttac aagaaaatac tatagaaaaa actttaaaag catcagattt aatagaattt 1500

1560

tttgatcaag caagtgcaaa atatcaattt gagaaatatg taagagatta tactggtgga 1620

tctctttctg aagacaatgg ggtagacttt aataaaaata ctgccctcga caaaaactat 1680

ttattaaata ataaaattcc atcaaacaat gtagaagaag ctggaagtaa aaattatgtt 1740

1800

tctaaaaatc ctaaaaatag tattattata caacgaaata tgaatgaaag tgcaaaaagc 1860

tactttttaa gtgatgatgg agaatctatt ttagaattaa ataaatatag gatacctgaa 1920

agattaaaaa ataaggaaaa agtaaaagta acctttattg gacatggtaa agatgaattc 1980

aacacaagcg aatttgctag attaagtgta gattcacttt ccaatgagat aagttcattt 2040

ttagatacca taaaattaga tatatcacct aaaaatgtag aagtaaactt acttggatgt 2100

aatatgttta gttatgattt taatgttgaa gaaacttatc ctgggaagtt gctattaagt 2160

attatggaca aaattacttc cactttacct gatgtaaata aaaattctat tactatagga 2220

gcaaatcaat atgaagtaag aattaatagt gagggaagaa aagaacttct ggctcactca 2280

ggtaaatgga taaataaaga agaagctatt atgagcgatt tatctagtaa agaatacatt 2340

ttttttgatt ctatagataa taagctaaaa gcaaagtcca agaatattcc aggattagca 2400

tcaatatcag aagatataaa aacattatta cttgatgcaa gtgttagtcc tgatacaaaa 2460

tttattttaa ataatcttaa gcttaatatt gaatcttcta ttggtgatta catttattat 2520

2580

ttcaatctac ttgaaaatgt atctgatgaa ttatatgaat taaaaaaatt aaataatcta 2640

gatgagaagt atttaatatc ttttgaagat atctcaaaaa ataattcaac ttactctgta 2700

agatttatta acaaaagtaa tggtgagtca gtttatgtag aaacagaaaa agaaattttt 2760

2820

2880

ttaaacgcag cattctttat tcaatcatta atagattata gtagcaataa agatgtactg 2940

aatgatttaa gtacctcagt taaggttcaa ctttatgctc aactatttag tacaggttta 3000

aatactatat atgactctat ccaattagta aatttaatat caaatgcagt aaatgatact 3060

ataaatgtac tacctacaat aacagagggg atacctattg tatctactat attagacgga 3120

ataaacttag gtgcagcaat taaggaatta ctagacgaac atgacccatt actaaaaaaa 3180

gaattagaag ctaaggtggg tgttttagca ataaatatgt cattatctat agctgcaact 3240

gtagcttcaa ttgttggaat aggtgctgaa gttactattt tcttattacc tatagctggt 3300

atatctgcag gaataccttc attagttaat aatgaattaa tattgcatga taaggcaact 3360

tcagtggtaa actattttaa tcatttgtct gaatctaaaa aatatggccc tcttaaaaca 3420

3480

aataattcga taaaactagg aacatgtaat atattagcaa tggagggggg atcaggacac 3540

acagtgactg gtaatataga tcactttttc tcatctccat ctataagttc tcatattcct 3600

3660

ataatgatgt tacctaatgc tccttcaaga gtgttttggt gggaaactgg agcagttcca 3720

3780

ccaggtaaat tttactggag attctatgct tttttcgatt atgcaataac tacattaaaa 3840

ccagtttatg aagacactaa tattaaaatt aaactagata aagatactag aaacttcata 3900

atgccaacta taactactaa cgaaattaga aacaaattat cttattcatt tgatggagca 3960

ggaggaactt actctttatt attatcttca tatccaatat caacgaatat aaatttatct 4020

4080

ggtactatta aaaaaggaaa gttaataaaa gatgttttaa gtaaaattga tataaataaa 4140

aataaactta ttataggcaa tcaaacaata gatttttcag gcgatataga taataaagat 4200

agatatatat tcttgacttg tgagttagat gataaaatta gtttaataat agaaataaat 4260

cttgttgcaa aatcttatag tttgttattg tctggggata aaaattattt gatatccaat 4320

ttatctaata ttattgagaa aatcaatact ttaggcctag atagtaaaaa tatagcgtac 4380

aattacactg atgaatctaa taataaatat tttggagcta tatctaaaac aagtcaaaaa 4440

agcataatac attataaaaa agacagtaaa aatatattag aattttataa tgacagtaca 4500

ttagaattta acagtaaaga ttttattgct gaagatataa atgtatttat gaaagatgat 4560

attaatacta taacaggaaa atactatgtt gataataata ctgataaaag tatagatttc 4620

tctatttctt tagttagtaa aaatcaagta aaagtaaatg gattatattt aaatgaatcc 4680

gtatactcat cttaccttga ttttgtgaaa aattcagatg gacaccataa tacttctaat 4740

tttatgaatt tatttttgga caatataagt ttctggaaat tgtttggggtt tgaaaatata 4800

aattttgtaa tcgataaata ctttaccctt gttggtaaaa ctaatcttgg atatgtagaa 4860

acaataataa aaatatagat atatattttg gtgaatggaa aacatcgtca 4920

tctaaaagca ctatatttag cggaaatggt agaaatgttg tagtagagcc tatatataat 4980

cctgatacgg gtgaagatat atctacttca ctagattttt cctatgaacc tctctatgga 5040

atagatagat atatcaataa agtattgata gcacctgatt tatatacaag tttaataaat 5100

attaatacca attattattc aaatgagtac taccctgaga ttatagttct taacccaaat 5160

acattccaca aaaaagtaaa tataaattta gatagttctt cttttgagta taaatggtct 5220

acagaaggaa gtgactttat tttagttaga tacttagaag aaagtaataa aaaaatatta 5280

caaaaaataa gaatcaaagg tatcttatct aatactcaat catttaataa aatgagtata 5340

gattttaaag atattaaaaa actatcatta ggatatataa tgagtaattt taaatcattt 5400

aattctgaaa atgaattaga tagagatcat ttaggattta aaataataga taataaaact 5460

tattactatg atgaagatag taaattagtt aaaggattaa tcaatataaa taattcatta 5520

ttctattttg atcctataga atttaactta gtaactggat ggcaaactat caatggtaaa 5580

aaatattatt ttgatataaa tactggagca gctttaatta gttataaaat tattaatggt 5640

aaacactttt attttaataa tgatggtgtg atgcagttgg gagtatttaa aggacctgat 5700

ggatttgaat attttgcacc tgccaatact caaaataata acatagaagg tcaggctata 5760

gtttatcaaa gtaaattctt aactttgaat ggcaaaaaat attattttga taatgactca 5820

aaagcagtca ctggatggag aattattaac aatgagaaat attactttaa tcctaataat 5880

gctattgctg cagtcggatt gcaagtaatt gacaataata agtattattt caatcctgac 5940

actgctatca tctcaaaagg ttggcagact gttaatggta gtagatacta ctttgatact 6000

6060

6120

6180

ttaactttga atggtaaaaa atattacttt gataataact caaaagcagt taccggatgg 6240

caaactattg atagtaaaaa atattacttt aatactaaca ctgctgaagc agctactgga 6300

tggcaaacta ttgatggtaa aaaatattac tttaatacta acactgctga agcagctact 6360

ggatggcaaa ctattgatgg taaaaaatat tactttaata ctaacactgc tatagcttca 6420

actggttata caattattaa tggtaaacat ttttatttta atactgatgg tattatgcag 6480

ataggagtgt ttaaaggacc taatggattt gaatattttg cacctgctaa tacggatgct 6540

6600

aaatattact ttggtagtga ctcaaaagca gttactggat ggagaattat taacaataag 6660

aaatattact ttaatcctaa taatgctatt gctgcaattc atctatgcac tataaataat 6720

6780

6840

aatactcaca ataataacat agaaggtcag 6900

gctatagttt accagaacaa attcttaact ttgaatggca aaaaatatta ttttgataat 6960

gactcaaaag cagttactgg atggcaaacc attgatggta aaaaatatta ctttaatctt 7020

aacactgctg aagcagctac tggatggcaa actattgatg gtaaaaaata ttactttaat 7080

cttaacactg ctgaagcagc tactggatgg caaactattg atggtaaaaa atattacttt 7140

aatactaaca ctttcatagc ctcaactggt tatacaagta ttaatggtaa acatttttat 7200

tttaatactg atggtattat gcagatagga gtgtttaaag gacctaatgg atttgaatac 7260

tttgcacctg ctaatactca taataataac atagaaggtc aagctatact ttaccaaaat 7320

aaattcttaa ctttgaatgg taaaaaatat tactttggta gtgactcaaa agcagttacc 7380

ggattgcgaa ctattgatgg taaaaaatat tactttaata ctaacactgc tgttgcagtt 7440

actggatggc aaactattaa tggtaaaaaa tactacttta atactaacac ttctatagct 7500

tcaactggtt atacaattat tagtggtaaa catttttatt ttaatactga tggtattatg 7560

cagataggag tgtttaaagg acctgatgga tttgaatact ttgcacctgc taatacagat 7620

7680

aatatatatt attttggtaa taattcaaaa gcagctactg gttgggtaac tattgatggt 7740

aatagatatt acttcgagcc taatacagct atgggtgcga atggttataa aactattgat 7800

aataaaaatt tttactttag aaatggttta cctcagatag gagtgtttaa agggtctaat 7860

ggatttgaat actttgcacc tgctaatacg gatgctaaca atatagaagg tcaagctata 7920

cgttatcaaa atagattcct acatttactt ggaaaaatat attactttgg taataattca 7980

aaagcagtta ctggatggca aactattaat ggtaaagtat attactttat gcctgatact 8040

gctatggctg cagctggtgg acttttcgag attgatggtg ttatatattt ctttggtgtt 8100

gatggagtaa aagcccctgg gatatatggc taa 8133

<210> 10

<211> 7101

<212> DNA

<213> Clostridium difficile

<400> 10

atgagtttag ttaatagaaa acagttagaa aaaatggcaa atgtaagatt tcgtactcaa 60

gaagatgaat atgttgcaat attggatgct ttagaagaat atcataatat gtcagagaat 120

actgtagtcg aaaaatattt aaaattaaaa gatataaata gtttaacaga tattatata 180

gatacatata aaaaatctgg tagaaataaa gccttaaaaa aatttaagga atatctagtt 240

acagaagtat tagagctaaa gaataataat ttaactccag ttgagaaaaa tttacatttt 300

360

gtaaatagtg attataatgt taatgttttt tatgatagta atgcattttt gataaacaca 420

ttgaaaaaaa ctgtagtaga atcagcaata aatgatacac ttgaatcatt tagagaaaac 480

ttaaatgacc ctagatttga ctataataaa ttcttcagaa aacgtatgga aataatttat 540

gataaacaga aaaatttcat aaactactat aaagctcaaa gagaagaaaa tcctgaactt 600

ataattgatg atattgtaaa gacatatctt tcaaatgagt attcaaagga gatagatgaa 660

cttaatacct atattgaaga atccttaaat aaaattacac agaatagtgg aaatgatgtt 720

agaaactttg aagaatttaa aaatggagag tcattcaact tatatgaaca agagttggta 780

gaaaggtgga atttagctgc tgcttctgac atattaagaa tatctgcatt aaaagaaatt 840

ggtggtatgt atttagatgt tgatatgtta cggaatac aaccagactt atttgagtct 900

atagagaaac ctagttcagt aacagtggat ttttgggaaa tgacaaagtt agaagctata 960

atgaaataca aagaatatat accagaatat acctcagaac attttgacat gttagacgaa 1020

gaagttcaaa gtagttttga atctgttcta gcttctaagt cagataaatc agaaatattc 1080

tcatcacttg gtgatatgga ggcatcacca ctagaagtta aaattgcatt taatagtaag 1140

ggtattataa atcaagggct aatttctgtg aaagactcat attgtagcaa tttaatagta 1200

1260

gataatgatt ttaatactac aacgaatacc tttattgata gtataatggc tgaagctaat 1320

gcagataatg gtagatttat gatggaacta ggaaagtatt taagagttgg tttcttccca 1380

gatgttaaaa ctactattaa cttaagtggc cctgaagcat atgcggcagc ttatcaagat 1440

ttattaatgt ttaaagaagg cagtatgaat atccatttga tagaagctga tttaagaaac 1500

tttgaaatct ctaaaactaa tatttctcaa tcaactgaac aagaaatggc tagcttatgg 1560

1620

ggttctcttg gtgaagatga taatcttgat ttttctcaaa atatagtagt tgacaaggag 1680

aaaaaatatc ttcattagca agaagttcag agagaggata tatacactat 1740

1800

actccttatg atagtgtact gtttcagaaa aatatagaag attcagaaat tgcatattat 1860

tataatcctg gagatggtga aatacaagaa atagacaagt ataaaattcc aagtataatt 1920

tctgatagac ctaagattaa attaacattt attggtcatg gtaaagatga atttaatact 1980

gatatatttg caggttttga tgtagattca ttatccacag aaatagaagc agcaatagat 2040

ttagctaaag aggatatttc tcctaagtca atagaaataa atttattagg atgtaatatg 2100

tttagctact ctatcaacgt agaggagact tatcctggaa aattattact taaagttaaa 2160

gataaaatat cagaattaat gccatctata agtcaagact ctattatagt aagtgcaaat 2220

caatatgaag ttagaataaa tagtgaagga agaagaat tattggatca ttctggtgaa 2280

tggataaata aagaagaaag tattataaag gatatttcat caaaagaata tatatcattt 2340

aatcctaaag aaaataaaat tacagtaaaa tctaaaaatt tacctgagct atctacatta 2400

ttacaagaaa ttagaaataa ttctaattca agtgatattg aactagaaga aaaagtaatg 2460

2520

attgaagaag ctaagaattt aacttctgac tctattaatt atataaaaga tgaatttaaa 2580

ctaatagaat ctatttctga tgcactatgt gacttaaaac aacagaatga attagaagat 2640

2700

attaataaag aaactggaga atctatattt gtagaaactg aaaaaacaat attctctgaa 2760

tatgctaatc atataactga agagatttct aagataaaag gtactatatt tgatactgta 2820

aatggtaagt tagtaaaaaa agtaaattta gatactacacacgaagtaaa tactttaaat 2880

gctgcatttt ttatacaatc attaatagaa tataatagtt ctaaagaatc tcttagtaat 2940

ttaagtgtag caatgaaagt ccaagtttac gctcaattat ttagtactgg tttaaatact 3000

3060

ttacttccta cattatctga aggattacct ataattgcaa ctattataga tggtgtaagt 3120

ttaggtgcag caatcaaaga gctaagtgaa acgagtgacc cattattaag acaagaaata 3180

gaagctaaga taggtataat ggcagtaaat ttaacaacag ctacaactgc aatcattact 3240

tcatctttgg ggatagctag tggatttagt atacttttag ttcctttagc aggaatttca 3300

3360

3420

3480

tcaatagttt taggtaaatg tgaaatctgg agaatggaag gtggttcagg tcatactgta 3540

actgatgata tagatcactt cttttcagca ccatcaataa catatagaga gccacactta 3600

3660

gtattaccta atgctccaaa tagagtattt gcttgggaaa caggatggac accaggttta 3720

agaagcttag aaaatgatgg cacaaaactg ttagaccgta taagagataa ctatgaaggt 3780

3840

agatatgaag atactaatat aagaataaat ttagatagta atactagaag ttttatagtt 3900

ccaataataa ctacagaata tataagagaa aaattatcat attctttcta tggttcagga 3960

ggaacttatg cattgtctct ttctcaatat aatatgggta taaatataga attaagtgaa 4020

4080

aaaattaaaa aaggtgattt aatagaaggt attttatcta cactaagtat tgaagagaat 4140

aaaattatct taaatagcca tgagattaat ttttctggtg aggtaaatgg aagtaatgga 4200

tttgtttctt taacattttc aattttagaa ggaataaatg caattataga agttgattta 4260

ttatctaaat catataaatt acttatttct ggcgaattaa aaatattgat gttaaattca 4320

aatcatattc aacagaaaat agattatata ggattcaata gcgaattaca gaaaaatata 4380

ccatatagct ttgtagatag tgaaggaaaa gagaatggtt ttattaatgg ttcaacaaaa 4440

gaaggtttat ttgtatctga attacctgat gtagttctta taagtaaggt ttatatggat 4500

gatagtaagc cttcatttgg atattatagt aataatttga aagatgtcaa agttataact 4560

aaagataatg ttaatatatt aacaggttat tatcttaagg atgatataaa aatctctctt 4620

4680

ggagtagctg agattttgaa gttcatgaat agaaaaggta atacaaatac ttcagattct 4740

ttaatgagct ttttagaaag tatgaatata aaaagtattt tcgttaattt cttacaatct 4800

aatattaagt ttatattaga tgctaatttt ataataagtg gtactacttc tattggccaa 4860

tttgagttta tttgtgatga aaatgataat atacaaccat atttcattaa gtttaataca 4920

ctagaaacta attatacttt atatgtagga aatagacaaa atatgatagt ggaaccaaat 4980

tcaatttctc tcaaaagtat 5040

5100

gaaataaata taacgcctgt atatgaaaca aataatactt atccagaagt tattgtatta 5160

gatgcaaatt atataaatga aaaaataaat gttaatatca atgatctatc tatacgatat 5220

gtatggagta atgatggtaa tgattttatt cttatgtcaa ctagtgaaga aaataaggtg 5280

tcacaagtta aaataagatt cgttaatgtt tttaaagata agactttggc aaataagcta 5340

tcttttaact ttagtgataa acaagatgta cctgtaagtg aaataatctt atcatttaca 5400

ccttcatatt atgaggatgg attgattggc tatgatttgg gtctagtttc tttatataat 5460

gagaaatttt atattaataa ctttggaatg atggtatctg gattaatata tattaatgat 5520

tcattatatt attttaaacc accagtaaat aatttgataa ctggatttgt gactgtaggc 5580

gatgataaat actactttaa tccaattaat ggtggagctg cttcaattgg agagacaata 5640

attgatgaca aaaattatta tttcaaccaa agtggagtgt tacaaacagg tgtatttagt 5700

acagaagatg gatttaaata ttttgcccca gctaatacac ttgatgaaaa cctagaagga 5760

gaagcaattg attttactgg aaaattaatt attgacgaaa atatttatta ttttgatgat 5820

aattatagag gagctgtaga atggaaagaa ttagatggtg aaatgcacta ttttagccca 5880

gaaacaggta aagcttttaa aggtctaaat caaataggtg attataaata ctatttcaat 5940

tctgatggag ttatgcaaaa aggatttgtt agtataaatg ataataaaca ctattttgat 6000

gattctggtg ttatgaaagt aggttacact gaaatagatg gcaagcattt ctactttgct 6060

6120

catcataatg aagatttagg aaatgaagaa ggtgaagaaa tctcatattc tggtatatta 6180

6240

gatttagagg atggttcaaa gtattatttt gatgaagata cagcagaagc atatataggt 6300

ttgtcattaa taaatgatgg tcaatattat tttaatgatg atggaattat gcaagttgga 6360

tttgtcacta taaatgataa agtcttctac ttctctgact ctggaattat agaatctgga 6420

gtacaaaaca tagatgacaa ttatttctat tagatgata atggtatagt tcaaattggt 6480

gtatttgata cttcagatgg atataaatat tttgcacctg ctaatactgt aaatgataat 6540

atttacggac aagcagttga atatagtggt ttagttagag ttggtgaaga tgtatattat 6600

6660

aaatattatt tcaatccaga aactaaaaaa gcatgcaaag gtattaattt aattgatgat 6720

ataaaatatt attttgatga gaagggcata atgagaacgg gtcttatatc atttgaaaat 6780

aataattatt actttaatga gaatggtgaa atgcaatttg gttatataaa tatagaagat 6840

aagatgttct attttggtga agatggtgtc atgcagattg gagtatttaa tacaccagat 6900

ggatttaaat actttgcaca tcaaaatact ttggatgaga attttgaggg agaatcaata 6960

aactatactg gttggttaga tttagatgaa aagagatatt attttacaga tgaatatatt 7020

7080 gcagcaactg gttcagttat tattgatggt gaggagtatt

caattagtga ttagtgaata g 7101

<210> 11

<211> 8133

<212> DNA

<213> Artificial

<220>

<223> Synthetic nucleotide sequence: TcdA gene (mutations

D285A D287A)

<400> 11

atgtctttaa tatctaaaga agagttaata aaactcgcat atagcattag accaagagaa 60

aatgagtata aaactatact aactaattta gacgaatata ataagttaac tacaaacaat 120

aatgaaaata aatatttaca attaaaaaaa ctaaatgaat caattgatgt ttttatgaat 180

aaatataaaa cttcaagcag aaatagagca ctctctaatc taaaaaaaga tatattaaaa 240

gaagtaattc ttattaaaaa ttccaataca agccctgtag aaaaaaattt acattttgta 300

tggataggtg gagaagtcag tgatattgct cttgaataca taaaacaatg ggctgatatt 360

aatgcagaat ataatattaa actgtggtat gatagtgaag cattcttagt aaatacacta 420

aaaaaggcta tagttgaatc ttctaccact gaagcattac agctactaga ggaagagatt 480

caaaatcctc aatttgataa tatgaaattt tacaaaaaaa ggatggaatt tatatatgat 540

agacaaaaaa ggtttataaa ttattataaa tctcaaatca ataaacctac agtacctaca 600

atagatgata ttataaagtc tcatctagta tctgaatata atagatga aactgtatta 660

gaatcatata gaacaaattc tttgagaaaa ataaatagta atcatgggat agatatcagg 720

gctaatagtt tgtttacaga acaagagtta ttaaatattt atagtcagga gttgttaaat 780

cgtggaaatt tagctgcagc atctgacata gtaagattat tagccctaaa aaattttggc 840

ggagtatatt tagcagttgc aatgcttcca ggtattcact ctgatttatt taaaacaata 900

tctagaccta gctctattgg actagaccgt tgggaaatga taaaattaga ggctattatg 960

1020

1080

1140 aaattagaaa atttaaatgt atctgatctt gaaattaaaa

gttataaatc aagccttgat atcaaaacaa ggttcatatc ttactaacct agtaatagaa 1200

1260

aataacttca cagatactac taaaattttt catgattcat tatttaattc agctaccgca 1320

gaaaactcta tgtttttaac aaaaatagca ccatacttac aagtaggttt tatgccagaa 1380

gctcgctcca caataagttt aagtggtcca ggagcttatg cgtcagctta ctatgatttc 1440

ataaatttac aagaaaatac tatagaaaaa actttaaaag catcagattt aatagaattt 1500

1560

tttgatcaag caagtgcaaa atatcaattt gagaaatatg taagagatta tactggtgga 1620

tctctttctg aagacaatgg ggtagacttt aataaaaata ctgccctcga caaaaactat 1680

ttattaaata ataaaattcc atcaaacaat gtagaagaag ctggaagtaa aaattatgtt 1740

1800

tctaaaaatc ctaaaaatag tattattata caacgaaata tgaatgaaag tgcaaaaagc 1860

tactttttaa gtgatgatgg agaatctatt ttagaattaa ataaatatag gatacctgaa 1920

agattaaaaa ataaggaaaa agtaaaagta acctttattg gacatggtaa agatgaattc 1980

aacacaagcg aatttgctag attaagtgta gattcacttt ccaatgagat aagttcattt 2040

ttagatacca taaaattaga tatatcacct aaaaatgtag aagtaaactt acttggatgt 2100

aatatgttta gttatgattt taatgttgaa gaaacttatc ctgggaagtt gctattaagt 2160

attatggaca aaattacttc cactttacct gatgtaaata aaaattctat tactatagga 2220

gcaaatcaat atgaagtaag aattaatagt gagggaagaa aagaacttct ggctcactca 2280

ggtaaatgga taaataaaga agaagctatt atgagcgatt tatctagtaa agaatacatt 2340

ttttttgatt ctatagataa taagctaaaa gcaaagtcca agaatattcc aggattagca 2400

tcaatatcag aagatataaa aacattatta cttgatgcaa gtgttagtcc tgatacaaaa 2460

tttattttaa ataatcttaa gcttaatatt gaatcttcta ttggtgatta catttattat 2520

2580

ttcaatctac ttgaaaatgt atctgatgaa ttatatgaat taaaaaaatt aaataatcta 2640

gatgagaagt atttaatatc ttttgaagat atctcaaaaa ataattcaac ttactctgta 2700

agatttatta acaaaagtaa tggtgagtca gtttatgtag aaacagaaaa agaaattttt 2760

2820

2880

ttaaacgcag cattctttat tcaatcatta atagattata gtagcaataa agatgtactg 2940

aatgatttaa gtacctcagt taaggttcaa ctttatgctc aactatttag tacaggttta 3000

aatactatat atgactctat ccaattagta aatttaatat caaatgcagt aaatgatact 3060

ataaatgtac tacctacaat aacagagggg atacctattg tatctactat attagacgga 3120

ataaacttag gtgcagcaat taaggaatta ctagacgaac atgacccatt actaaaaaaa 3180

gaattagaag ctaaggtggg tgttttagca ataaatatgt cattatctat agctgcaact 3240

gtagcttcaa ttgttggaat aggtgctgaa gttactattt tcttattacc tatagctggt 3300

atatctgcag gaataccttc attagttaat aatgaattaa tattgcatga taaggcaact 3360

tcagtggtaa actattttaa tcatttgtct gaatctaaaa aatatggccc tcttaaaaca 3420

3480

aataattcga taaaactagg aacatgtaat atattagcaa tggagggggg atcaggacac 3540

acagtgactg gtaatataga tcactttttc tcatctccat ctataagttc tcatattcct 3600

3660

ataatgatgt tacctaatgc tccttcaaga gtgttttggt gggaaactgg agcagttcca 3720

3780

ccaggtaaat tttactggag attctatgct tttttcgatt atgcaataac tacattaaaa 3840

ccagtttatg aagacactaa tattaaaatt aaactagata aagatactag aaacttcata 3900

atgccaacta taactactaa cgaaattaga aacaaattat cttattcatt tgatggagca 3960

ggaggaactt actctttatt attatcttca tatccaatat caacgaatat aaatttatct 4020

4080

ggtactatta aaaaaggaaa gttaataaaa gatgttttaa gtaaaattga tataaataaa 4140

aataaactta ttataggcaa tcaaacaata gatttttcag gcgatataga taataaagat 4200

agatatatat tcttgacttg tgagttagat gataaaatta gtttaataat agaaataaat 4260

cttgttgcaa aatcttatag tttgttattg tctggggata aaaattattt gatatccaat 4320

ttatctaata ttattgagaa aatcaatact ttaggactag atagtaaaaa tatagcgtac 4380

aattacactg atgaatctaa taataaatat tttggagcta tatctaaaac aagtcaaaaa 4440

agcataatac attataaaaa agacagtaaa aatatattag aattttataa tgacagtaca 4500

ttagaattta acagtaaaga ttttattgct gaagatataa atgtatttat gaaagatgat 4560

attaatacta taacaggaaa atactatgtt gataataata ctgataaaag tatagatttc 4620

tctatttctt tagttagtaa aaatcaagta aaagtaaatg gattatattt aaatgaatcc 4680

gtatactcat cttaccttga ttttgtgaaa aattcagatg gacaccataa tacttctaat 4740

tttatgaatt tatttttgga caatataagt ttctggaaat tgtttggggtt tgaaaatata 4800

aattttgtaa tcgataaata ctttaccctt gttggtaaaa ctaatcttgg atatgtagaa 4860

acaataataa aaatatagat atatattttg gtgaatggaa aacatcgtca 4920

tctaaaagca ctatatttag cggaaatggt agaaatgttg tagtagagcc tatatataat 4980

cctgatacgg gtgaagatat atctacttca ctagattttt cctatgaacc tctctatgga 5040

atagatagat atatcaataa agtattgata gcacctgatt tatatacaag tttaataaat 5100

attaatacca attattattc aaatgagtac taccctgaga ttatagttct taacccaaat 5160

acattccaca aaaaagtaaa tataaattta gatagttctt cttttgagta taaatggtct 5220

acagaaggaa gtgactttat tttagttaga tacttagaag aaagtaataa aaaaatatta 5280

caaaaaataa gaatcaaagg tatcttatct aatactcaat catttaataa aatgagtata 5340

gattttaaag atattaaaaa actatcatta ggatatataa tgagtaattt taaatcattt 5400

aattctgaaa atgaattaga tagagatcat ttaggattta aaataataga taataaaact 5460

tattactatg atgaagatag taaattagtt aaaggattaa tcaatataaa taattcatta 5520

ttctattttg atcctataga atttaactta gtaactggat ggcaaactat caatggtaaa 5580

aaatattatt ttgatataaa tactggagca gctttaatta gttataaaat tattaatggt 5640

aaacactttt attttaataa tgatggtgtg atgcagttgg gagtatttaa aggacctgat 5700

ggatttgaat attttgcacc tgccaatact caaaataata acatagaagg tcaggctata 5760

gtttatcaaa gtaaattctt aactttgaat ggcaaaaaat attattttga taatgactca 5820

aaagcagtca ctggatggag aattattaac aatgagaaat attactttaa tcctaataat 5880

gctattgctg cagtcggatt gcaagtaatt gacaataata agtattattt caatcctgac 5940

actgctatca tctcaaaagg ttggcagact gttaatggta gtagatacta ctttgatact 6000

6060

6120

6180

ttaactttga atggtaaaaa atattacttt gataataact caaaagcagt taccggatgg 6240

caaactattg atagtaaaaa atattacttt aatactaaca ctgctgaagc agctactgga 6300

tggcaaacta ttgatggtaa aaaatattac tttaatacta acactgctga agcagctact 6360

ggatggcaaa ctattgatgg taaaaaatat tactttaata ctaacactgc tatagcttca 6420

actggttata caattattaa tggtaaacat ttttatttta atactgatgg tattatgcag 6480

ataggagtgt ttaaaggacc taatggattt gaatattttg cacctgctaa tacggatgct 6540

6600

aaatattact ttggtagtga ctcaaaagca gttactggat ggagaattat taacaataag 6660

aaatattact ttaatcctaa taatgctatt gctgcaattc atctatgcac tataaataat 6720

6780

6840

aatactcaca ataataacat agaaggtcag 6900

gctatagttt accagaacaa attcttaact ttgaatggca aaaaatatta ttttgataat 6960

gactcaaaag cagttactgg atggcaaacc attgatggta aaaaatatta ctttaatctt 7020

aacactgctg aagcagctac tggatggcaa actattgatg gtaaaaaata ttactttaat 7080

cttaacactg ctgaagcagc tactggatgg caaactattg atggtaaaaa atattacttt 7140

aatactaaca ctttcatagc ctcaactggt tatacaagta ttaatggtaa acatttttat 7200

tttaatactg atggtattat gcagatagga gtgtttaaag gacctaatgg atttgaatac 7260

tttgcacctg ctaatactca taataataac atagaaggtc aagctatact ttaccaaaat 7320

aaattcttaa ctttgaatgg taaaaaatat tactttggta gtgactcaaa agcagttacc 7380

ggattgcgaa ctattgatgg taaaaaatat tactttaata ctaacactgc tgttgcagtt 7440

actggatggc aaactattaa tggtaaaaaa tactacttta atactaacac ttctatagct 7500

tcaactggtt atacaattat tagtggtaaa catttttatt ttaatactga tggtattatg 7560

cagataggag tgtttaaagg acctgatgga tttgaatact ttgcacctgc taatacagat 7620

7680

aatatatatt attttggtaa taattcaaaa gcagctactg gttgggtaac tattgatggt 7740

aatagatatt acttcgagcc taatacagct atgggtgcga atggttataa aactattgat 7800

aataaaaatt tttactttag aaatggttta cctcagatag gagtgtttaa agggtctaat 7860

ggatttgaat actttgcacc tgctaatacg gatgctaaca atatagaagg tcaagctata 7920

cgttatcaaa atagattcct acatttactt ggaaaaatat attactttgg taataattca 7980

aaagcagtta ctggatggca aactattaat ggtaaagtat attactttat gcctgatact 8040

gctatggctg cagcaggtgg acttttcgag attgatggtg ttatatattt ctttggtgtt 8100

gatggagtaa aagcccctgg gatatatggc taa 8133

<210> 12

<211> 8133

<212> DNA

<213> Artificial

<220>

<223> Synthetic nucleotide sequence: TcdA gene (mutations

D285A D287A C700A)

<400> 12

atgtctttaa tatctaaaga agagttaata aaactcgcat atagcattag accaagagaa 60

aatgagtata aaactatact aactaattta gacgaatata ataagttaac tacaaacaat 120

aatgaaaata aatatttaca attaaaaaaa ctaaatgaat caattgatgt ttttatgaat 180

aaatataaaa cttcaagcag aaatagagca ctctctaatc taaaaaaaga tatattaaaa 240

gaagtaattc ttattaaaaa ttccaataca agccctgtag aaaaaaattt acattttgta 300

tggataggtg gagaagtcag tgatattgct cttgaataca taaaacaatg ggctgatatt 360

aatgcagaat ataatattaa actgtggtat gatagtgaag cattcttagt aaatacacta 420

aaaaaggcta tagttgaatc ttctaccact gaagcattac agctactaga ggaagagatt 480

caaaatcctc aatttgataa tatgaaattt tacaaaaaaa ggatggaatt tatatatgat 540

agacaaaaaa ggtttataaa ttattataaa tctcaaatca ataaacctac agtacctaca 600

atagatgata ttataaagtc tcatctagta tctgaatata atagatga aactgtatta 660

gaatcatata gaacaaattc tttgagaaaa ataaatagta atcatgggat agatatcagg 720

gctaatagtt tgtttacaga acaagagtta ttaaatattt atagtcagga gttgttaaat 780

cgtggaaatt tagctgcagc atctgacata gtaagattat tagccctaaa aaattttggc 840

ggagtatatt tagcagttgc aatgcttcca ggtattcact ctgatttatt taaaacaata 900

tctagaccta gctctattgg actagaccgt tgggaaatga taaaattaga ggctattatg 960

1020

1080

1140 aaattagaaa atttaaatgt atctgatctt gaaattaaaa

gttataaatc aagccttgat atcaaaacaa ggttcatatc ttactaacct agtaatagaa 1200

1260

aataacttca cagatactac taaaattttt catgattcat tatttaattc agctaccgca 1320

gaaaactcta tgtttttaac aaaaatagca ccatacttac aagtaggttt tatgccagaa 1380

gctcgctcca caataagttt aagtggtcca ggagcttatg cgtcagctta ctatgatttc 1440

ataaatttac aagaaaatac tatagaaaaa actttaaaag catcagattt aatagaattt 1500

1560

tttgatcaag caagtgcaaa atatcaattt gagaaatatg taagagatta tactggtgga 1620

tctctttctg aagacaatgg ggtagacttt aataaaaata ctgccctcga caaaaactat 1680

ttattaaata ataaaattcc atcaaacaat gtagaagaag ctggaagtaa aaattatgtt 1740

1800

tctaaaaatc ctaaaaatag tattattata caacgaaata tgaatgaaag tgcaaaaagc 1860

tactttttaa gtgatgatgg agaatctatt ttagaattaa ataaatatag gatacctgaa 1920

agattaaaaa ataaggaaaa agtaaaagta acctttattg gacatggtaa agatgaattc 1980

aacacaagcg aatttgctag attaagtgta gattcacttt ccaatgagat aagttcattt 2040

ttagatacca taaaattaga tatatcacct aaaaatgtag aagtaaactt acttggagct 2100

aatatgttta gttatgattt taatgttgaa gaaacttatc ctgggaagtt gctattaagt 2160

attatggaca aaattacttc cactttacct gatgtaaata aaaattctat tactatagga 2220

gcaaatcaat atgaagtaag aattaatagt gagggaagaa aagaacttct ggctcactca 2280

ggtaaatgga taaataaaga agaagctatt atgagcgatt tatctagtaa agaatacatt 2340

ttttttgatt ctatagataa taagctaaaa gcaaagtcca agaatattcc aggattagca 2400

tcaatatcag aagatataaa aacattatta cttgatgcaa gtgttagtcc tgatacaaaa 2460

tttattttaa ataatcttaa gcttaatatt gaatcttcta ttggtgatta catttattat 2520

2580

ttcaatctac ttgaaaatgt atctgatgaa ttatatgaat taaaaaaatt aaataatcta 2640

gatgagaagt atttaatatc ttttgaagat atctcaaaaa ataattcaac ttactctgta 2700

agatttatta acaaaagtaa tggtgagtca gtttatgtag aaacagaaaa agaaattttt 2760

2820

2880

ttaaacgcag cattctttat tcaatcatta atagattata gtagcaataa agatgtactg 2940

aatgatttaa gtacctcagt taaggttcaa ctttatgctc aactatttag tacaggttta 3000

aatactatat atgactctat ccaattagta aatttaatat caaatgcagt aaatgatact 3060

ataaatgtac tacctacaat aacagagggg atacctattg tatctactat attagacgga 3120

ataaacttag gtgcagcaat taaggaatta ctagacgaac atgacccatt actaaaaaaa 3180

gaattagaag ctaaggtggg tgttttagca ataaatatgt cattatctat agctgcaact 3240

gtagcttcaa ttgttggaat aggtgctgaa gttactattt tcttattacc tatagctggt 3300

atatctgcag gaataccttc attagttaat aatgaattaa tattgcatga taaggcaact 3360

tcagtggtaa actattttaa tcatttgtct gaatctaaaa aatatggccc tcttaaaaca 3420

3480

aataattcga taaaactagg aacatgtaat atattagcaa tggagggggg atcaggacac 3540

acagtgactg gtaatataga tcactttttc tcatctccat ctataagttc tcatattcct 3600

3660

ataatgatgt tacctaatgc tccttcaaga gtgttttggt gggaaactgg agcagttcca 3720

3780

ccaggtaaat tttactggag attctatgct tttttcgatt atgcaataac tacattaaaa 3840

ccagtttatg aagacactaa tattaaaatt aaactagata aagatactag aaacttcata 3900

atgccaacta taactactaa cgaaattaga aacaaattat cttattcatt tgatggagca 3960

ggaggaactt actctttatt attatcttca tatccaatat caacgaatat aaatttatct 4020

4080

ggtactatta aaaaaggaaa gttaataaaa gatgttttaa gtaaaattga tataaataaa 4140

aataaactta ttataggcaa tcaaacaata gatttttcag gcgatataga taataaagat 4200

agatatatat tcttgacttg tgagttagat gataaaatta gtttaataat agaaataaat 4260

cttgttgcaa aatcttatag tttgttattg tctggggata aaaattattt gatatccaat 4320

ttatctaata ttattgagaa aatcaatact ttaggactag atagtaaaaa tatagcgtac 4380

aattacactg atgaatctaa taataaatat tttggagcta tatctaaaac aagtcaaaaa 4440

agcataatac attataaaaa agacagtaaa aatatattag aattttataa tgacagtaca 4500

ttagaattta acagtaaaga ttttattgct gaagatataa atgtatttat gaaagatgat 4560

attaatacta taacaggaaa atactatgtt gataataata ctgataaaag tatagatttc 4620

tctatttctt tagttagtaa aaatcaagta aaagtaaatg gattatattt aaatgaatcc 4680

gtatactcat cttaccttga ttttgtgaaa aattcagatg gacaccataa tacttctaat 4740

tttatgaatt tatttttgga caatataagt ttctggaaat tgtttggggtt tgaaaatata 4800

aattttgtaa tcgataaata ctttaccctt gttggtaaaa ctaatcttgg atatgtagaa 4860

acaataataa aaatatagat atatattttg gtgaatggaa aacatcgtca 4920

tctaaaagca ctatatttag cggaaatggt agaaatgttg tagtagagcc tatatataat 4980

cctgatacgg gtgaagatat atctacttca ctagattttt cctatgaacc tctctatgga 5040

atagatagat atatcaataa agtattgata gcacctgatt tatatacaag tttaataaat 5100

attaatacca attattattc aaatgagtac taccctgaga ttatagttct taacccaaat 5160

acattccaca aaaaagtaaa tataaattta gatagttctt cttttgagta taaatggtct 5220

acagaaggaa gtgactttat tttagttaga tacttagaag aaagtaataa aaaaatatta 5280

caaaaaataa gaatcaaagg tatcttatct aatactcaat catttaataa aatgagtata 5340

gattttaaag atattaaaaa actatcatta ggatatataa tgagtaattt taaatcattt 5400

aattctgaaa atgaattaga tagagatcat ttaggattta aaataataga taataaaact 5460

tattactatg atgaagatag taaattagtt aaaggattaa tcaatataaa taattcatta 5520

ttctattttg atcctataga atttaactta gtaactggat ggcaaactat caatggtaaa 5580

aaatattatt ttgatataaa tactggagca gctttaatta gttataaaat tattaatggt 5640

aaacactttt attttaataa tgatggtgtg atgcagttgg gagtatttaa aggacctgat 5700

ggatttgaat attttgcacc tgccaatact caaaataata acatagaagg tcaggctata 5760

gtttatcaaa gtaaattctt aactttgaat ggcaaaaaat attattttga taatgactca 5820

aaagcagtca ctggatggag aattattaac aatgagaaat attactttaa tcctaataat 5880

gctattgctg cagtcggatt gcaagtaatt gacaataata agtattattt caatcctgac 5940

actgctatca tctcaaaagg ttggcagact gttaatggta gtagatacta ctttgatact 6000

6060

6120

6180

ttaactttga atggtaaaaa atattacttt gataataact caaaagcagt taccggatgg 6240

caaactattg atagtaaaaa atattacttt aatactaaca ctgctgaagc agctactgga 6300

tggcaaacta ttgatggtaa aaaatattac tttaatacta acactgctga agcagctact 6360

ggatggcaaa ctattgatgg taaaaaatat tactttaata ctaacactgc tatagcttca 6420

actggttata caattattaa tggtaaacat ttttatttta atactgatgg tattatgcag 6480

ataggagtgt ttaaaggacc taatggattt gaatattttg cacctgctaa tacggatgct 6540

6600

aaatattact ttggtagtga ctcaaaagca gttactggat ggagaattat taacaataag 6660

aaatattact ttaatcctaa taatgctatt gctgcaattc atctatgcac tataaataat 6720

6780

6840

aatactcaca ataataacat agaaggtcag 6900

gctatagttt accagaacaa attcttaact ttgaatggca aaaaatatta ttttgataat 6960

gactcaaaag cagttactgg atggcaaacc attgatggta aaaaatatta ctttaatctt 7020

aacactgctg aagcagctac tggatggcaa actattgatg gtaaaaaata ttactttaat 7080

cttaacactg ctgaagcagc tactggatgg caaactattg atggtaaaaa atattacttt 7140

aatactaaca ctttcatagc ctcaactggt tatacaagta ttaatggtaa acatttttat 7200

tttaatactg atggtattat gcagatagga gtgtttaaag gacctaatgg atttgaatac 7260

tttgcacctg ctaatactca taataataac atagaaggtc aagctatact ttaccaaaat 7320

aaattcttaa ctttgaatgg taaaaaatat tactttggta gtgactcaaa agcagttacc 7380

ggattgcgaa ctattgatgg taaaaaatat tactttaata ctaacactgc tgttgcagtt 7440

actggatggc aaactattaa tggtaaaaaa tactacttta atactaacac ttctatagct 7500

tcaactggtt atacaattat tagtggtaaa catttttatt ttaatactga tggtattatg 7560

cagataggag tgtttaaagg acctgatgga tttgaatact ttgcacctgc taatacagat 7620

7680

aatatatatt attttggtaa taattcaaaa gcagctactg gttgggtaac tattgatggt 7740

aatagatatt acttcgagcc taatacagct atgggtgcga atggttataa aactattgat 7800

aataaaaatt tttactttag aaatggttta cctcagatag gagtgtttaa agggtctaat 7860

ggatttgaat actttgcacc tgctaatacg gatgctaaca atatagaagg tcaagctata 7920

cgttatcaaa atagattcct acatttactt ggaaaaatat attactttgg taataattca 7980

aaagcagtta ctggatggca aactattaat ggtaaagtat attactttat gcctgatact 8040

gctatggctg cagcaggtgg acttttcgag attgatggtg ttatatattt ctttggtgtt 8100

gatggagtaa aagcccctgg gatatatggc taa 8133

<210> 13

<211> 7101

<212> DNA

<213> Artificial

<220>

<223> Synthetic nucleotide sequence: TcdB (mutations

D286A D288A)

<400> 13

atgagtttag ttaatagaaa acagttagaa aaaatggcaa atgtaagatt tcgtactcaa 60

gaagatgaat atgttgcaat attggatgct ttagaagaat atcataatat gtcagagaat 120

actgtagtcg aaaaatattt aaaattaaaa gatataaata gtttaacaga tattatata 180

gatacatata aaaaatctgg tagaaataaa gccttaaaaa aatttaagga atatctagtt 240

acagaagtat tagagctaaa gaataataat ttaactccag ttgagaaaaa tttacatttt 300

gtttggattg gaggtcaaat 360

gtaaatagtg attataatgt taatgttttt tatgatagta atgcattttt gataaacaca 420

ttgaaaaaaa ctgtagtaga atcagcaata aatgatacac ttgaatcatt tagagaaaac 480

ttaaatgacc ctagatttga ctataataaa ttcttcagaa aacgtatgga aataatttat 540

gataaacaga aaaatttcat aaactactat aaagctcaaa gagaagaaaa tcctgaactt 600

ataattgatg atattgtaaa gacatatctt tcaaatgagt attcaaagga gatagatgaa 660

cttaatacct atattgaaga atccttaaat aaaattacac agaatagtgg aaatgatgtt 720

agaaactttg aagaatttaa aaatggagag tcattcaact tatatgaaca agagttggta 780

gaaaggtgga atttagctgc tgcttctgac atattaagaa tatctgcatt aaaagaaatt 840

ggtggtatgt atttagcagt tgcaatgtta cggaatac aaccagactt atttgagtct 900

atagagaaac ctagttcagt aacagtggat ttttgggaaa tgacaaagtt agaagctata 960

atgaaataca aagaatatat accagaatat acctcagaac attttgacat gttagacgaa 1020

gaagttcaaa gtagttttga atctgttcta gcttctaagt cagataaatc agaaatattc 1080

tcatcacttg gtgatatgga ggcatcacca ctagaagtta aaattgcatt taatagtaag 1140

ggtattataa atcaagggct aatttctgtg aaagactcat attgtagcaa tttaatagta 1200

1260

gataatgatt ttaatactac aacgaatacc tttattgata gtataatggc tgaagctaat 1320

gcagataatg gtagatttat gatggaacta ggaaagtatt taagagttgg tttcttccca 1380

gatgttaaaa ctactattaa cttaagtggc cctgaagctt atgcggcagc ttatcaagat 1440

ttattaatgt ttaaagaagg cagtatgaat atccatttga tagaagctga tttaagaaac 1500

tttgaaatct ctaaaactaa tatttctcaa tcaactgaac aagaaatggc ttctttatgg 1560

1620

ggttctcttg gtgaagatga taatcttgat ttttctcaaa atatagtagt tgacaaggag 1680

aaaaaatatc ttcattagca agaagttcag agagaggata tatacactat 1740

1800

actccttatg atagtgtact gtttcagaaa aatatagaag attcagaaat tgcatattat 1860

tataatcctg gagatggtga aatacaagaa atagacaagt ataaaattcc aagtataatt 1920

tctgatagac ctaagattaa attaacattt attggtcatg gtaaagatga atttaatact 1980

gatatatttg caggttttga tgtagattca ttatccacag aaatagaagc agcaatagat 2040

ttagctaaag aggatatttc tcctaagtca atagaaataa atttattagg atgtaatatg 2100

tttagctact ctatcaacgt agaggagact tatcctggaa aattattact taaagttaaa 2160

gataaaatat cagaattaat gccatctata agtcaagact ctattatagt aagtgcaaat 2220

caatatgaag ttagaataaa tagtgaagga agaagaat tattggatca ttctggtgaa 2280

tggataaata aagaagaaag tattataaag gatatttcat caaaagaata tatatcattt 2340

aatcctaaag aaaataaaat tacagtaaaa tctaaaaatt tacctgagct atctacatta 2400

ttacaagaaa ttagaaataa ttctaattca agtgatattg aactagaaga aaaagtaatg 2460

2520

attgaagaag ctaagaattt aacttctgac tctattaatt atataaaaga tgaatttaaa 2580

ctaatagaat ctatttctga tgcactatgt gacttaaaac aacagaatga attagaagat 2640

2700

attaataaag aaactggaga atctatattt gtagaaactg aaaaaacaat attctctgaa 2760

tatgctaatc atataactga agagatttct aagataaaag gtactatatt tgatactgta 2820

aatggtaagt tagtaaaaaa agtaaattta gatactacacacgaagtaaa tactttaaat 2880

gctgcatttt ttatacaatc attaatagaa tataatagtt ctaaagaatc tcttagtaat 2940

ttaagtgtag caatgaaagt ccaagtttac gctcaattat ttagtactgg tttaaatact 3000

3060

ttacttccta cattatctga aggattacct ataattgcaa ctattataga tggtgtaagt 3120

ttaggtgcag caatcaaaga gctaagtgaa acgagtgacc cattattaag acaagaaata 3180

gaagctaaga taggtataat ggcagtaaat ttaacaacag ctacaactgc aatcattact 3240

tcatctttgg ggatagctag tggatttagt atacttttag ttcctttagc aggaatttca 3300

3360

3420

3480

tcaatagttt taggtaaatg tgaaatctgg agaatggaag gtggttcagg tcatactgta 3540

actgatgata tagatcactt cttttcagca ccatcaataa catatagaga gccacactta 3600

3660

gtattaccta atgctccaaa tagagtattt gcttgggaaa caggatggac accaggttta 3720

agaagcttag aaaatgatgg cacaaaactg ttagaccgta taagagataa ctatgaaggt 3780

3840

agatatgaag atactaatat aagaataaat ttagatagta atactagaag ttttatagtt 3900

ccaataataa ctacagaata tataagagaa aaattatcat attctttcta tggttcagga 3960

ggaacttatg cattgtctct ttctcaatat aatatgggta taaatataga attaagtgaa 4020

4080

aaaattaaaa aaggtgattt aatagaaggt attttatcta cactaagtat tgaagagaat 4140

aaaattatct taaatagcca tgagattaat ttttctggtg aggtaaatgg aagtaatgga 4200

tttgtttctt taacattttc aattttagaa ggaataaatg caattataga agttgattta 4260

ttatctaaat catataaatt acttatttct ggcgaattaa aaatattgat gttaaattca 4320

aatcatattc aacagaaaat agattatata ggattcaata gcgaattaca gaaaaatata 4380

ccatatagct ttgtagatag tgaaggaaaa gagaatggtt ttattaatgg ttcaacaaaa 4440

gaaggtttat ttgtatctga attacctgat gtagttctta taagtaaggt ttatatggat 4500

gatagtaagc cttcatttgg atattatagt aataatttga aagatgtcaa agttataact 4560

aaagataatg ttaatatatt aacaggttat tatcttaagg atgatataaa aatctctctt 4620

4680

ggagtagctg agattttgaa gttcatgaat agaaaaggta atacaaatac ttcagattct 4740

ttaatgagct ttttagaaag tatgaatata aaaagtattt tcgttaattt cttacaatct 4800

aatattaagt ttatattaga tgctaatttt ataataagtg gtactacttc tattggccaa 4860

tttgagttta tttgtgatga aaatgataat atacaaccat atttcattaa gtttaataca 4920

ctagaaacta attatacttt atatgtagga aatagacaaa atatgatagt ggaaccaaat 4980

tcaatttctc tcaaaagtat 5040

5100

gaaataaata taacgcctgt atatgaaaca aataatactt atccagaagt tattgtatta 5160

gatgcaaatt atataaatga aaaaataaat gttaatatca atgatctatc tatacgatat 5220

gtatggagta atgatggtaa tgattttatt cttatgtcaa ctagtgaaga aaataaggtg 5280

tcacaagtta aaataagatt cgttaatgtt tttaaagata agactttggc aaataagcta 5340

tcttttaact ttagtgataa acaagatgta cctgtaagtg aaataatctt atcatttaca 5400

ccttcatatt atgaggatgg attgattggc tatgatttgg gtctagtttc tttatataat 5460

gagaaatttt atattaataa ctttggaatg atggtatctg gattaatata tattaatgat 5520

tcattatatt attttaaacc accagtaaat aatttgataa ctggatttgt gactgtaggc 5580

gatgataaat actactttaa tccaattaat ggtggagctg cttcaattgg agagacaata 5640

attgatgaca aaaattatta tttcaaccaa agtggagtgt tacaaacagg tgtatttagt 5700

acagaagatg gatttaaata ttttgcccca gctaatacac ttgatgaaaa cctagaagga 5760

gaagcaattg attttactgg aaaattaatt attgacgaaa atatttatta ttttgatgat 5820

aattatagag gagctgtaga atggaaagaa ttagatggtg aaatgcacta ttttagccca 5880

gaaacaggta aagcttttaa aggtctaaat caaataggtg attataaata ctatttcaat 5940

tctgatggag ttatgcaaaa aggatttgtt agtataaatg ataataaaca ctattttgat 6000

gattctggtg ttatgaaagt aggttacact gaaatagatg gcaagcattt ctactttgct 6060

6120

catcataatg aagatttagg aaatgaagaa ggtgaagaaa tctcatattc tggtatatta 6180

6240

gatttagagg atggttcaaa gtattatttt gatgaagata cagcagaagc atatataggt 6300

ttgtcattaa taaatgatgg tcaatattat tttaatgatg atggaattat gcaagttgga 6360

tttgtcacta taaatgataa agtcttctac ttctctgact ctggaattat agaatctgga 6420

gtacaaaaca tagatgacaa ttatttctat tagatgata atggtatagt tcaaattggt 6480

gtatttgata cttcagatgg atataaatat tttgcacctg ctaatactgt aaatgataat 6540

atttacggac aagcagttga atatagtggt ttagttagag ttggtgaaga tgtatattat 6600

6660

aaatattatt tcaatccaga aactaaaaaa gcatgcaaag gtattaattt aattgatgat 6720

ataaaatatt attttgatga gaagggcata atgagaacgg gtcttatatc atttgaaaat 6780

aataattatt actttaatga gaatggtgaa atgcaatttg gttatataaa tatagaagat 6840

aagatgttct attttggtga agatggtgtc atgcagattg gagtatttaa tacaccagat 6900

ggatttaaat actttgcaca tcaaaatact ttggatgaga attttgaggg agaatcaata 6960

aactatactg gttggttaga tttagatgaa aagagatatt attttacaga tgaatatatt 7020

7080 gcagcaactg gttcagttat tattgatggt gaggagtatt

caattagtga ttagtgaata g 7101

<210> 14

<211> 7101

<212> DNA

<213> Artificial

<220>

<223> Synthetic nucleotide sequence: TcdB (mutations

D286A D288A C698A)

<400> 14

atgagtttag ttaatagaaa acagttagaa aaaatggcaa atgtaagatt tcgtactcaa 60

gaagatgaat atgttgcaat attggatgct ttagaagaat atcataatat gtcagagaat 120

actgtagtcg aaaaatattt aaaattaaaa gatataaata gtttaacaga tattatata 180

gatacatata aaaaatctgg tagaaataaa gccttaaaaa aatttaagga atatctagtt 240

acagaagtat tagagctaaa gaataataat ttaactccag ttgagaaaaa tttacatttt 300

360

gtaaatagtg attataatgt taatgttttt tatgatagta atgcattttt gataaacaca 420

ttgaaaaaaa ctgtagtaga atcagcaata aatgatacac ttgaatcatt tagagaaaac 480

ttaaatgacc ctagatttga ctataataaa ttcttcagaa aacgtatgga aataatttat 540

gataaacaga aaaatttcat aaactactat aaagctcaaa gagaagaaaa tcctgaactt 600

ataattgatg atattgtaaa gacatatctt tcaaatgagt attcaaagga gatagatgaa 660

cttaatacct atattgaaga atccttaaat aaaattacac agaatagtgg aaatgatgtt 720

agaaactttg aagaatttaa aaatggagag tcattcaact tatatgaaca agagttggta 780

gaaaggtgga atttagctgc tgcttctgac atattaagaa tatctgcatt aaaagaaatt 840

ggtggtatgt atttagcagt tgcaatgtta cggaatac aaccagactt atttgagtct 900

atagagaaac ctagttcagt aacagtggat ttttgggaaa tgacaaagtt agaagctata 960

atgaaataca aagaatatat accagaatat acctcagaac attttgacat gttagacgaa 1020

gaagttcaaa gtagttttga atctgttcta gcttctaagt cagataaatc agaaatattc 1080

tcatcacttg gtgatatgga ggcatcacca ctagaagtta aaattgcatt taatagtaag 1140

ggtattataa atcaagggct aatttctgtg aaagactcat attgtagcaa tttaatagta 1200

1260

gataatgatt ttaatactac aacgaatacc tttattgata gtataatggc tgaagctaat 1320

gcagataatg gtagatttat gatggaacta ggaaagtatt taagagttgg tttcttccca 1380

gatgttaaaa ctactattaa cttaagtggc cctgaagctt atgcggcagc ttatcaagat 1440

ttattaatgt ttaaagaagg cagtatgaat atccatttga tagaagctga tttaagaaac 1500

tttgaaatct ctaaaactaa tatttctcaa tcaactgaac aagaaatggc ttctttatgg 1560

1620

ggttctcttg gtgaagatga taatcttgat ttttctcaaa atatagtagt tgacaaggag 1680

aaaaaatatc ttcattagca agaagttcag agagaggata tatacactat 1740

1800

actccttatg atagtgtact gtttcagaaa aatatagaag attcagaaat tgcatattat 1860

tataatcctg gagatggtga aatacaagaa atagacaagt ataaaattcc aagtataatt 1920

tctgatagac ctaagattaa attaacattt attggtcatg gtaaagatga atttaatact 1980

gatatatttg caggttttga tgtagattca ttatccacag aaatagaagc agcaatagat 2040

ttagctaaag aggatatttc tcctaagtca atagaaataa atttattagg agctaatatg 2100

tttagctact ctatcaacgt agaggagact tatcctggaa aattattact taaagttaaa 2160

gataaaatat cagaattaat gccatctata agtcaagact ctattatagt aagtgcaaat 2220

caatatgaag ttagaataaa tagtgaagga agaagaat tattggatca ttctggtgaa 2280

tggataaata aagaagaaag tattataaag gatatttcat caaaagaata tatatcattt 2340

aatcctaaag aaaataaaat tacagtaaaa tctaaaaatt tacctgagct atctacatta 2400

ttacaagaaa ttagaaataa ttctaattca agtgatattg aactagaaga aaaagtaatg 2460

2520

attgaagaag ctaagaattt aacttctgac tctattaatt atataaaaga tgaatttaaa 2580

ctaatagaat ctatttctga tgcactatgt gacttaaaac aacagaatga attagaagat 2640

2700

attaataaag aaactggaga atctatattt gtagaaactg aaaaaacaat attctctgaa 2760

tatgctaatc atataactga agagatttct aagataaaag gtactatatt tgatactgta 2820

aatggtaagt tagtaaaaaa agtaaattta gatactacacacgaagtaaa tactttaaat 2880

gctgcatttt ttatacaatc attaatagaa tataatagtt ctaaagaatc tcttagtaat 2940

ttaagtgtag caatgaaagt ccaagtttac gctcaattat ttagtactgg tttaaatact 3000

3060

ttacttccta cattatctga aggattacct ataattgcaa ctattataga tggtgtaagt 3120

ttaggtgcag caatcaaaga gctaagtgaa acgagtgacc cattattaag acaagaaata 3180

gaagctaaga taggtataat ggcagtaaat ttaacaacag ctacaactgc aatcattact 3240

tcatctttgg ggatagctag tggatttagt atacttttag ttcctttagc aggaatttca 3300

3360

3420

3480

tcaatagttt taggtaaatg tgaaatctgg agaatggaag gtggttcagg tcatactgta 3540

actgatgata tagatcactt cttttcagca ccatcaataa catatagaga gccacactta 3600

3660

gtattaccta atgctccaaa tagagtattt gcttgggaaa caggatggac accaggttta 3720

agaagcttag aaaatgatgg cacaaaactg ttagaccgta taagagataa ctatgaaggt 3780

3840

agatatgaag atactaatat aagaataaat ttagatagta atactagaag ttttatagtt 3900

ccaataataa ctacagaata tataagagaa aaattatcat attctttcta tggttcagga 3960

ggaacttatg cattgtctct ttctcaatat aatatgggta taaatataga attaagtgaa 4020

4080

aaaattaaaa aaggtgattt aatagaaggt attttatcta cactaagtat tgaagagaat 4140

aaaattatct taaatagcca tgagattaat ttttctggtg aggtaaatgg aagtaatgga 4200

tttgtttctt taacattttc aattttagaa ggaataaatg caattataga agttgattta 4260

ttatctaaat catataaatt acttatttct ggcgaattaa aaatattgat gttaaattca 4320

aatcatattc aacagaaaat agattatata ggattcaata gcgaattaca gaaaaatata 4380

ccatatagct ttgtagatag tgaaggaaaa gagaatggtt ttattaatgg ttcaacaaaa 4440

gaaggtttat ttgtatctga attacctgat gtagttctta taagtaaggt ttatatggat 4500

gatagtaagc cttcatttgg atattatagt aataatttga aagatgtcaa agttataact 4560

aaagataatg ttaatatatt aacaggttat tatcttaagg atgatataaa aatctctctt 4620

4680

ggagtagctg agattttgaa gttcatgaat agaaaaggta atacaaatac ttcagattct 4740

ttaatgagct ttttagaaag tatgaatata aaaagtattt tcgttaattt cttacaatct 4800

aatattaagt ttatattaga tgctaatttt ataataagtg gtactacttc tattggccaa 4860

tttgagttta tttgtgatga aaatgataat atacaaccat atttcattaa gtttaataca 4920

ctagaaacta attatacttt atatgtagga aatagacaaa atatgatagt ggaaccaaat 4980

tcaatttctc tcaaaagtat 5040

5100

gaaataaata taacgcctgt atatgaaaca aataatactt atccagaagt tattgtatta 5160

gatgcaaatt atataaatga aaaaataaat gttaatatca atgatctatc tatacgatat 5220

gtatggagta atgatggtaa tgattttatt cttatgtcaa ctagtgaaga aaataaggtg 5280

tcacaagtta aaataagatt cgttaatgtt tttaaagata agactttggc aaataagcta 5340

tcttttaact ttagtgataa acaagatgta cctgtaagtg aaataatctt atcatttaca 5400

ccttcatatt atgaggatgg attgattggc tatgatttgg gtctagtttc tttatataat 5460

gagaaatttt atattaataa ctttggaatg atggtatctg gattaatata tattaatgat 5520

tcattatatt attttaaacc accagtaaat aatttgataa ctggatttgt gactgtaggc 5580

gatgataaat actactttaa tccaattaat ggtggagctg cttcaattgg agagacaata 5640

attgatgaca aaaattatta tttcaaccaa agtggagtgt tacaaacagg tgtatttagt 5700

acagaagatg gatttaaata ttttgcccca gctaatacac ttgatgaaaa cctagaagga 5760

gaagcaattg attttactgg aaaattaatt attgacgaaa atatttatta ttttgatgat 5820

aattatagag gagctgtaga atggaaagaa ttagatggtg aaatgcacta ttttagccca 5880

gaaacaggta aagcttttaa aggtctaaat caaataggtg attataaata ctatttcaat 5940

tctgatggag ttatgcaaaa aggatttgtt agtataaatg ataataaaca ctattttgat 6000

gattctggtg ttatgaaagt aggttacact gaaatagatg gcaagcattt ctactttgct 6060

6120

catcataatg aagatttagg aaatgaagaa ggtgaagaaa tctcatattc tggtatatta 6180

6240

gatttagagg atggttcaaa gtattatttt gatgaagata cagcagaagc atatataggt 6300

ttgtcattaa taaatgatgg tcaatattat tttaatgatg atggaattat gcaagttgga 6360

tttgtcacta taaatgataa agtcttctac ttctctgact ctggaattat agaatctgga 6420

gtacaaaaca tagatgacaa ttatttctat tagatgata atggtatagt tcaaattggt 6480

gtatttgata cttcagatgg atataaatat tttgcacctg ctaatactgt aaatgataat 6540

atttacggac aagcagttga atatagtggt ttagttagag ttggtgaaga tgtatattat 6600

6660

aaatattatt tcaatccaga aactaaaaaa gcatgcaaag gtattaattt aattgatgat 6720

ataaaatatt attttgatga gaagggcata atgagaacgg gtcttatatc atttgaaaat 6780

aataattatt actttaatga gaatggtgaa atgcaatttg gttatataaa tatagaagat 6840

aagatgttct attttggtga agatggtgtc atgcagattg gagtatttaa tacaccagat 6900

ggatttaaat actttgcaca tcaaaatact ttggatgaga attttgaggg agaatcaata 6960

aactatactg gttggttaga tttagatgaa aagagatatt attttacaga tgaatatatt 7020

7080 gcagcaactg gttcagttat tattgatggt gaggagtatt

caattagtga ttagtgaata g 7101

<210> 15

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 15

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 16

<211> 8133

<212> DNA

<213> Clostridium difficile

<400> 16

atgtctttaa tatctaaaga agagttaata aaactcgcat atagcattag accaagagaa 60

aatgagtata aaactatact aactaattta gacgaatata ataagttaac tacaaacaat 120

aatgaaaata aatatttaca attaaaaaaa ctaaatgaat caattgatgt ttttatgaat 180

aaatataaaa attcaagcag aaatagagca ctctctaatc taaaaaaaga tatattaaaa 240

gaagtaattc ttattaaaaa ttccaataca agtcctgtag aaaaaaattt acattttgta 300

tggataggtg gagaagtcag tgatattgct cttgaataca taaaacaatg ggctgatatt 360

aatgcagaat ataatattaa actgtggtat gatagtgaag cattcttagt caatacacta 420

aaaaaggcta tagttgaatc ttctaccact gaagcattac agctactaga ggaagagatt 480

caaaatcctc aatttgataa tatgaaattt tacaaaaaaa ggatggaatt tatatatgat 540

agacaaaaaa ggtttataaa ttattataaa tctcaaatca ataaacctac agtacctaca 600

atagatgata ttataaagtc tcatctagta tctgaatata atagatga aactttatta 660

gaatcatata gaacaaattc tttgagaaaa ataaatagta atcatgggat agatatcagg 720

gctaatagtt tgtttacaga acaagagtta ttaaatattt atagtcagga gttgttaaat 780

cgtgggaatt tagctgcagc atctgacata gtaagattat tagccctaaa aaattttggc 840

ggagtatatt tagatgttga tatgcttcca ggtattcact ctgatttatt taaaacaata 900

cctagaccta gctctattgg actagaccgt tgggaaatga taaaattaga ggctattatg 960

1020

1080

1140 aaattagaaa atttaaatgt atctgatctt gaaattaaaa

gttataaatc aagccttgat atcaaaacaa ggttcatatc ttactaacct agtaatagaa 1200

1260

aataacttca cagatactac taagattttt catgattcac tatttaattc agctaccgca 1320

gaaaactcta tgtttttaac aaaaatagca ccatacttac aagtaggttt tatgccagaa 1380

gctcgctcca caataagttt aagtggtcca ggagcttatg catcagctta ctatgatttc 1440

ataaatttac aagaaaatac tatagaaaaa actttaaaag catcagattt aatagaattt 1500

1560

tttgatcaag caagtgcaaa atatcaattt gagaaatatg taagagatta tactggtgga 1620

tctctttctg aagacaatgg ggtagacttt aataaaaata ctgccctcga caaaaactat 1680

ttattaaata ataaaattcc atcaaacaat gtagaagaag ctggaagtaa aaattatgtt 1740

1800

tctaaaaatc ctaaaaatag tattattata caacgaaata tgaatgaaag tgcaaaaagt 1860

tactttttaa gtgatgatgg agaatctatt ttagaattaa ataaatatag gatacctgaa 1920

agattaaaaa ataaggaaaa agtaaaagta acctttattg gacatggtaa agatgaattc 1980

aacacaagcg aatttgctag attaagtgta gattcacttt ccaatgagat aagttcattt 2040

ttagatacca taaaattaga tatatcacct aaaaatgtag aagtaaactt gcttggatgt 2100

aatatgttta gttatgattt taatgttgaa gaaacttatc ctggtaagtt actattaagt 2160

attatggaca aaattacttc cactttacct gatgtaaata aagattctat tactatagga 2220

gcaaatcaat atgaagtaag aattaatagt gagggaagaa aagaacttct agctcactca 2280

ggtaaatgga taaataaaga ggaagctatt atgagcgatt tatctagtaa agaatacatt 2340

ttttttgatt ccatagataa taagctaaaa gcaaagtcca agaatattcc aggtttagcg 2400

tcaatatcag aagatataaa aacattatta cttgatgcaa gtgttagtcc tgatacaaaa 2460

tttattttaa ataatcttaa gcttaatatt gaatcttcta ttggtgatta catttattat 2520

gaaaaattag aacctgttaa aaatataatc cacaattcta tagatgattt aatagatgag 2580

ttcaatctac ttgaaaatgt atctgatgaa ttatatgaat taaaaaaatt aaataatcta 2640

gatgagaagt atttaatatc ttttgaagat atctcaaaaa ataattcaac ttattctgta 2700

agatttatta acaaaagtaa tggtgaatca gtttatgtag agacagaaaa agaaattttt 2760

2820

2880

ttaaacgcag cattctttat tcaatcatta atagattata gtagcaataa agatgtactg 2940

aatgatttaa gtacctcagt taaggttcaa ctttatgctc aactatttag tacaggttta 3000

aatactatat atgactctat ccaattagta aatttaatat caaatgcagt aaatgatact 3060

ataaatgtac tacctacaat aacagagggg atacctattg tatctactat attagacgga 3120

ataaacttag gtgcagcaat taaggaatta ctagacgaac atgacccatt actaaaaaaa 3180

gaactagaag ctaaggtggg tgttttagca ataaatatgt cattatctat agctgcaacg 3240

gtagcttcaa ttgttggaat aggtgctgaa gttactattt tcttattacc tatagctggt 3300

atatctgcgg gaataccttc attagttaat aatgaattaa tattgcatga taaggcaact 3360

tcagtggtaa actattttaa tcatttgtct gaatctaaag aatatggccc tcttaaaaca 3420

3480

aataattcga taaaactagg aacatgtaat atattagcaa tggagggggg atcaggacac 3540

acagtgactg gtaatataga tcactttttc tcatctccat atataagctc tcatattcct 3600

aataggtata aaaacagaaa atctagattt ttcaaaaaaa 3660

ataatgatgt taccaaatgc tccttcaaga gtgttttggt gggaaactgg agcagttcca 3720

3780

ccaggcaaat tttactggag attctatgcc tttttcgatt atgcaataac tacattaaaa 3840

ccagtgtatg aagacactaa tactaaaatt aaactagata aagatactag aaactttata 3900

atgccaacta taactactga cgaaattaga aacaaattat cttattcatt tgatggagca 3960

ggaggaactt actctttatt attatcttca tatccaatat caatgaatat aaatttatct 4020

4080

ggtactatta aaaaaggaaa tttaatagaa gatgttttaa gtaaaattga tataaataaa 4140

aataaactta ttataggcaa tcaaacaata gatttttcag gtgatataga taacaaagat 4200

agatatatat tcttgacttg tgagttagat gataaaatta gtttaataat agaaataaat 4260

cttgttgcaa aatcttatag tttgttattg tctggggata aaaattattt gatatccaat 4320

ttatctaata ctattgagaa aatcaatact ttaggcctag atagtaaaaa tatagcttac 4380

aattacactg atgaatctaa taataaatat tttggagcta tatctaaaac aagtcaaaaa 4440

agcataatac attataaaaa agacagtaaa aatatattag aattttataa tggcagtaca 4500

ttagaattta acagtaaaga ctttattgct gaagatataa atgtatttat gaaagatgat 4560

attaatacta taacaggaaa atactatgtt gataataata ctgataaaag tatagatttc 4620

tctatttctt tagttagtaa aaatcaagta aaagtaaatg gattatattt aaatgaatcc 4680

gtatactcat cttaccttga ttttgtgaaa aattcagatg gacaccataa tacttctaat 4740

tttatgaatt tatttttgaa caatataagt ttctggaaat tgtttggggtt tgaaaatata 4800

aattttgtaa tcgataaata ctttaccctt gttggtaaaa ctaatcttgg atatgtagaa 4860

acaataataa aaatatagat atatattttg gtgaatggaa aacatcgtca 4920

tctaaaagca ctatatttag cggaaatggt agaaatgttg tagtagagcc tatatataat 4980

cctgatacgg gtgaagatat atctacttca ctagattttt cctatgaacc tctctatgga 5040

atagatagat atatcaataa agtattgata gcacctgatt tatatacaag tttaataaat 5100

attaatacca attattattc aaatgagtac taccctgaga ttatagttct taacccaaat 5160

acattccaca aaaaagtaaa tataaattta gatagttctt cttttgagta taaatggtct 5220

acagaaggaa gtgactttat tttagttaga tacttagaag aaagtaataa aaaaatatta 5280

caaaaaataa gaatcaaagg tatcttatct aatactcaat catttaataa aatgagtata 5340

gattttaaag atattaaaaa actatcatta ggatatataa tgagtaattt taaatcattt 5400

aattctgaaa atgaattaga tagagatcat ttaggattta aaataataga taataaaact 5460

tattactatg atgaagatag taaattagtt aaaggattaa tcaatataaa taattcatta 5520

ttctattttg atcctataga atctaactta gtaactggat ggcaaactat caatggtaaa 5580

aaatattatt ttgatataaa tactggagca gcttcaacta gttataaaat tattaatggt 5640

aaacactttt attttaataa taatggtgtg atgcagttag gagtatttaa aggacctgat 5700

ggatttgagt attttgcacc tgccaatact cagaataata acatagaagg tcaggctata 5760

gtttatcaaa gtaaattctt aactttgaat ggcaaaaaat attattttga taatgactca 5820

aaagcagtca ctggatggag gattataac aatgagaaat attactttaa tcctaataat 5880

gctattgctg cagtcggatt gcaagtaatt gacaataata agtattattt caatcctgac 5940

actgctatca tctcaaaagg ttggcagact gttaatggta gtagatacta ctttgatact 6000

6060

agtgattgtg tagtgaaaat aggtgtgttt agtggctcta atggatttga atatttcgca 6120

6180

ttaactttga atggtaaaaa atattacttt gataataact caaaagcagt taccggatgg 6240

caaactattg atagtaaaaa atattacttt aatactaaca ctgctgaagc agctactgga 6300

tggcaaacta ttgatggtaa aaagtattac tttaatacta acactgctga agcagctact 6360

ggatggcaaa ctattgatgg taaaaaatat tactttaata ctaacacttc tatagcttca 6420

actggttata caattattaa tggtaaatat ttttatttta atactgatgg tattatgcag 6480

ataggagtgt ttaaagtacc taatggattt gaatactttg cacctgctaa tactcataat 6540

aataacatag aaggtcaagc tatactttac caaaataaat tcttaacttt gaatggtaaa 6600

aaatattact ttggtagtga ctcaaaagca attactggat ggcaaaccat tgatggtaaa 6660

aaatattact ttaatcctaa taatgctatt gctgcgactc atctatgcac tataaataac 6720

6780

6840

cctaatggat ttgagtattt tgcacctgct aatactcata ataataacat agaaggtcag 6900

gctatagttt accagaataa attcttaact ttgaatggca aaaaatatta ttttgataat 6960

gactcaaaag cagttactgg atggcaaact attgatagta aaaaatatta ctttaatctt 7020

aacactgctg ttgcagttac tggatggcaa actattgatg gtgaaaaata ttactttaat 7080

cttaacactg ctgaagcagc tactggatgg caaactattg atggtaaaag atactacttt 7140

aatactaaca cttatatagc ttcaactggt tatacgatta ttaatggtaa acatttttat 7200

tttaatactg atggtattat gcagatagga gtgtttaaag gacctgatgg atttgaatac 7260

tttgcacctg ctaatactca taataataac atagaaggtc aagctatact ttaccaaaat 7320

aaattcttaa ctttgaatgg taaaaaatat tactttggta gtgactcaaa agcagttacc 7380

ggattgcgaa ctattgatgg taaaaaatat tactttaata ctaacactgc tgttgcagtt 7440

actggatggc aaactattaa tggtaaaaaa tactacttta atactaacac ttatatagct 7500

tcaactggtt atacaattat tagtggtaaa catttttatt ttaatactga tggtattatg 7560

cagataggag tgtttaaagg acctgatgga tttgaatact ttgcacctgc taatacggat 7620

7680

aatatatatt actttggcaa tgattcaaaa gcggctactg gttgggcaac tattgatggt 7740

aatagatatt acttcgagcc taatacagct atgggtgcga atggttataa aactattgat 7800

aataaaaatt tttactttag aaatggttta cctcagatag gagtgtttaa aggacctaat 7860

ggatttgaat actttgcacc tgctaatacg gatgctaaca atatagatgg tcaagctata 7920

cgttatcaaa atagattcct acatttactt ggaaaaatat attactttgg taataactca 7980

aaagcagtta ctggatggca aactattaat agtaaagtat attactttat gcctgatact 8040

gctatggctg cagctggtgg acttttcgag attgatggtg ttatatattt ctttggtgtt 8100

gatggagtaa aagcccctgg gatatatggc taa 8133

<210> 17

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 17

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 18

<211> 8133

<212> DNA

<213> Clostridium difficile

<400> 18

atgtctttaa tatctaaaga agagttaata aaactcgcat atagcattag accaagagaa 60

aatgagtata aaactatact aactaattta gacgaatata ataagttaac tacaaacaat 120

aatgaaaata aatatttaca attaaaaaaa ctaaatgaat caattgatgt ttttatgaat 180

aaatataaaa attcaagcag aaatagagca ctctctaatc taaaaaaaga tatattaaaa 240

gaagtaattc ttattaaaaa ttccaataca agtcctgtag aaaaaaattt acattttgta 300

tggataggtg gagaagtcag tgatattgct cttgaataca taaaacaatg ggctgatatt 360

aatgcagaat ataatattaa actgtggtat gatagtgaag cattcttagt caatacacta 420

aaaaaggcta tagttgaatc ttctaccact gaagcattac agctactaga ggaagagatt 480

caaaatcctc aatttgataa tatgaaattt tacaaaaaaa ggatggaatt tatatatgat 540

agacaaaaaa ggtttataaa ttattataaa tctcaaatca ataaacctac agtacctaca 600

atagatgata ttataaagtc tcatctagta tctgaatata atagatga aactttatta 660

gaatcatata gaacaaattc tttgagaaaa ataaatagta atcatgggat agatatcagg 720

gctaatagtt tgtttacaga acaagagtta ttaaatattt atagtcagga gttgttaaat 780

cgtgggaatt tagctgcagc atctgacata gtaagattat tagccctaaa aaattttggc 840

ggagtatatt tagatgttga tatgcttcca ggtattcact ctgatttatt taaaacaata 900

cctagaccta gctctattgg actagaccgt tgggaaatga taaaattaga ggctattatg 960

1020

1080

1140 aaattagaaa atttaaatgt atctgatctt gaaattaaaa

gttataaatc aagccttgat atcaaaacaa ggttcatatc ttactaacct agtaatagaa 1200

1260

aataacttca cagatactac taagattttt catgattcac tatttaattc agctaccgca 1320

gaaaactcta tgtttttaac aaaaatagca ccatacttac aagtaggttt tatgccagaa 1380

gctcgctcca caataagttt aagtggtcca ggagcttatg catcagctta ctatgatttc 1440

ataaatttac aagaaaatac tatagaaaaa actttaaaag catcagattt aatagaattt 1500

1560

tttgatcaag caagtgcaaa atatcaattt gagaaatatg taagagatta tactggtgga 1620

tctctttctg aagacaatgg ggtagacttt aataaaaata ctgccctcga caaaaactat 1680

ttattaaata ataaaattcc atcaaacaat gtagaagaag ctggaagtaa aaattatgtt 1740

1800

tctaaaaatc ctaaaaatag tattattata caacgaaata tgaatgaaag tgcaaaaagt 1860

tactttttaa gtgatgatgg agaatctatt ttagaattaa ataaatatag gatacctgaa 1920

agattaaaaa ataaggaaaa agtaaaagta acctttattg gacatggtaa agatgaattc 1980

aacacaagcg aatttgctag attaagtgta gattcacttt ccaatgagat aagttcattt 2040

ttagatacca taaaattaga tatatcacct aaaaatgtag aagtaaactt gcttggatgt 2100

aatatgttta gttatgattt taatgttgaa gaaacttatc ctggtaagtt actattaagt 2160

attatggaca aaattacttc cactttacct gatgtaaata aagattctat tactatagga 2220

gcaaatcaat atgaagtaag aattaatagt gagggaagaa aagaacttct agctcactca 2280

ggtaaatgga taaataaaga ggaagctatt atgagcgatt tatctagtaa agaatacatt 2340

ttttttgatt ccatagataa taagctaaaa gcaaagtcca agaatattcc aggtttagcg 2400

tcaatatcag aagatataaa aacattatta cttgatgcaa gtgttagtcc tgatacaaaa 2460

tttattttaa ataatcttaa gcttaatatt gaatcttcta ttggtgatta catttattat 2520

gaaaaattag aacctgttaa aaatataatc cacaattcta tagatgattt aatagatgag 2580

ttcaatctac ttgaaaatgt atctgatgaa ttatatgaat taaaaaaatt aaataatcta 2640

gatgagaagt atttaatatc ttttgaagat atctcaaaaa ataattcaac ttattctgta 2700

agatttatta acaaaagtaa tggtgaatca gtttatgtag agacagaaaa agaaattttt 2760

2820

2880

ttaaacgcag cattctttat tcaatcatta atagattata gtagcaataa agatgtactg 2940

aatgatttaa gtacctcagt taaggttcaa ctttatgctc aactatttag tacaggttta 3000

aatactatat atgactctat ccaattagta aatttaatat caaatgcagt aaatgatact 3060

ataaatgtac tacctacaat aacagagggg atacctattg tatctactat attagacgga 3120

ataaacttag gtgcagcaat taaggaatta ctagacgaac atgacccatt actaaaaaaa 3180

gaactagaag ctaaggtggg tgttttagca ataaatatgt cattatctat agctgcaacg 3240

gtagcttcaa ttgttggaat aggtgctgaa gttactattt tcttattacc tatagctggt 3300

atatctgcgg gaataccttc attagttaat aatgaattaa tattgcatga taaggcaact 3360

tcagtggtaa actattttaa tcatttgtct gaatctaaag aatatggccc tcttaaaaca 3420

3480

aataattcga taaaactagg aacatgtaat atattagcaa tggagggggg atcaggacac 3540

acagtgactg gtaatataga tcactttttc tcatctccat atataagctc tcatattcct 3600

aataggtata aaaacagaaa atctagattt ttcaaaaaaa 3660

ataatgatgt taccaaatgc tccttcaaga gtgttttggt gggaaactgg agcagttcca 3720

3780

ccaggcaaat tttactggag attctatgcc tttttcgatt atgcaataac tacattaaaa 3840

ccagtgtatg aagacactaa tactaaaatt aaactagata aagatactag aaactttata 3900

atgccaacta taactactga cgaaattaga aacaaattat cttattcatt tgatggagca 3960

ggaggaactt actctttatt attatcttca tatccaatat caatgaatat aaatttatct 4020

4080

ggtactatta aaaaaggaaa tttaatagaa gatgttttaa gtaaaattga tataaataaa 4140

aataaactta ttataggcaa tcaaacaata gatttttcag gtgatataga taacaaagat 4200

agatatatat tcttgacttg tgagttagat gataaaatta gtttaataat agaaataaat 4260

cttgttgcaa aatcttatag tttgttattg tctggggata aaaattattt gatatccaat 4320

ttatctaata ctattgagaa aatcaatact ttaggcctag atagtaaaaa tatagcttac 4380

aattacactg atgaatctaa taataaatat tttggagcta tatctaaaac aagtcaaaaa 4440

agcataatac attataaaaa agacagtaaa aatatattag aattttataa tggcagtaca 4500

ttagaattta acagtaaaga ctttattgct gaagatataa atgtatttat gaaagatgat 4560

attaatacta taacaggaaa atactatgtt gataataata ctgataaaag tatagatttc 4620

tctatttctt tagttagtaa aaatcaagta aaagtaaatg gattatattt aaatgaatcc 4680

gtatactcat cttaccttga ttttgtgaaa aattcagatg gacaccataa tacttctaat 4740

tttatgaatt tatttttgaa caatataagt ttctggaaat tgtttggggtt tgaaaatata 4800

aattttgtaa tcgataaata ctttaccctt gttggtaaaa ctaatcttgg atatgtagaa 4860

acaataataa aaatatagat atatattttg gtgaatggaa aacatcgtca 4920

tctaaaagca ctatatttag cggaaatggt agaaatgttg tagtagagcc tatatataat 4980

cctgatacgg gtgaagatat atctacttca ctagattttt cctatgaacc tctctatgga 5040

atagatagat atatcaataa agtattgata gcacctgatt tatatacaag tttaataaat 5100

attaatacca attattattc aaatgagtac taccctgaga ttatagttct taacccaaat 5160

acattccaca aaaaagtaaa tataaattta gatagttctt cttttgagta taaatggtct 5220

acagaaggaa gtgactttat tttagttaga tacttagaag aaagtaataa aaaaatatta 5280

caaaaaataa gaatcaaagg tatcttatct aatactcaat catttaataa aatgagtata 5340

gattttaaag atattaaaaa actatcatta ggatatataa tgagtaattt taaatcattt 5400

aattctgaaa atgaattaga tagagatcat ttaggattta aaataataga taataaaact 5460

tattactatg atgaagatag taaattagtt aaaggattaa tcaatataaa taattcatta 5520

ttctattttg atcctataga atctaactta gtaactggat ggcaaactat caatggtaaa 5580

aaatattatt ttgatataaa tactggagca gcttcaacta gttataaaat tattaatggt 5640

aaacactttt attttaataa taatggtgtg atgcagttag gagtatttaa aggacctgat 5700

ggatttgagt attttgcacc tgccaatact cagaataata acatagaagg tcaggctata 5760

gtttatcaaa gtaaattctt aactttgaat ggcaaaaaat attattttga taatgactca 5820

aaagcagtca ctggatggag gattataac aatgagaaat attactttaa tcctaataat 5880

gctattgctg cagtcggatt gcaagtaatt gacaataata agtattattt caatcctgac 5940

actgctatca tctcaaaagg ttggcagact gttaatggta gtagatacta ctttgatact 6000

6060

agtgattgtg tagtgaaaat aggtgtgttt agtggctcta atggatttga atatttcgca 6120

6180

ttaactttga atggtaaaaa atattacttt gataataact caaaagcagt taccggatgg 6240

caaactattg atagtaaaaa atattacttt aatactaaca ctgctgaagc agctactgga 6300

tggcaaacta ttgatggtaa aaagtattac tttaatacta acactgctga agcagctact 6360

ggatggcaaa ctattgatgg taaaaaatat tactttaata ctaacacttc tatagcttca 6420

actggttata caattattaa tggtaaatat ttttatttta atactgatgg tattatgcag 6480

ataggagtgt ttaaagtacc taatggattt gaatactttg cacctgctaa tactcataat 6540

aataacatag aaggtcaagc tatactttac caaaataaat tcttaacttt gaatggtaaa 6600

aaatattact ttggtagtga ctcaaaagca attactggat ggcaaaccat tgatggtaaa 6660

aaatattact ttaatcctaa taatgctatt gctgcgactc atctatgcac tataaataac 6720

6780

6840

cctaatggat ttgagtattt tgcacctgct aatactcata ataataacat agaaggtcag 6900

gctatagttt accagaataa attcttaact ttgaatggca aaaaatatta ttttgataat 6960

gactcaaaag cagttactgg atggcaaact attgatagta aaaaatatta ctttaatctt 7020

aacactgctg ttgcagttac tggatggcaa actattgatg gtgaaaaata ttactttaat 7080

cttaacactg ctgaagcagc tactggatgg caaactattg atggtaaaag atactacttt 7140

aatactaaca cttatatagc ttcaactggt tatacgatta ttaatggtaa acatttttat 7200

tttaatactg atggtattat gcagatagga gtgtttaaag gacctgatgg atttgaatac 7260

tttgcacctg ctaatactca taataataac atagaaggtc aagctatact ttaccaaaat 7320

aaattcttaa ctttgaatgg taaaaaatat tactttggta gtgactcaaa agcagttacc 7380

ggattgcgaa ctattgatgg taaaaaatat tactttaata ctaacactgc tgttgcagtt 7440

actggatggc aaactattaa tggtaaaaaa tactacttta atactaacac ttatatagct 7500

tcaactggtt atacaattat tagtggtaaa catttttatt ttaatactga tggtattatg 7560

cagataggag tgtttaaagg acctgatgga tttgaatact ttgcacctgc taatacggat 7620

7680

aatatatatt actttggcaa tgattcaaaa gcggctactg gttgggcaac tattgatggt 7740

aatagatatt acttcgagcc taatacagct atgggtgcga atggttataa aactattgat 7800

aataaaaatt tttactttag aaatggttta cctcagatag gagtgtttaa aggacctaat 7860

ggatttgaat actttgcacc tgctaatacg gatgctaaca atatagatgg tcaagctata 7920

cgttatcaaa atagattcct acatttactt ggaaaaatat attactttgg taataactca 7980

aaagcagtta ctggatggca aactattaat agtaaagtat attactttat gcctgatact 8040

gctatggctg cagctggtgg acttttcgag attgatggtg ttatatattt ctttggtgtt 8100

gatggagtaa aagcccctgg gatatatggc taa 8133

<210> 19

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 19

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 20

<211> 8133

<212> DNA

<213> Clostridium difficile

<400> 20

atgtctttaa tatctaaaga agagttaata aaactcgcat atagcattag accaagagaa 60

aatgagtata aaactatact aactaattta gacgaatata ataagttaac tacaaacaat 120

aatgaaaata aatatttgca attaaaaaaa ctaaatgaat caattgatgt ttttatgaat 180

aaatataaaa cttcaagcag aaatagagca ctctctaatc taaaaaaaga tatattaaaa 240

gaagtaattc ttattaaaaa ttccaataca agccctgtag aaaaaaattt acattttgta 300

tggataggtg gagaagtcag tgatattgct cttgaataca taaaacaatg ggctgatatt 360

aatgcagaat ataatattaa actgtggtat gatagtgaag cattcttagt aaatacacta 420

aaaaaggcta tagttgaatc ttctaccact gaagcattac agctactaga ggaagagatt 480

caaaatcctc aatttgataa tatgaaattt tacaaaaaaa ggatggaatt tatatatgat 540

agacaaaaaa ggtttataaa ttattataaa tctcaaatca ataaacctac agtacctaca 600

atagatgata ttataaagtc tcatctagta tctgaatata atagatga aactgtatta 660

gaatcatata gaacaaattc tttgagaaaa ataaatagta atcatgggat agatatcagg 720

gctaatagtt tgtttacaga acaagagtta ttaaatattt atagtcagga gttgttaaat 780

cgtggaaatt tagctgcagc atctgacata gtaagattat tagccctaaa aaattttggc 840

ggagtatatt tagatgttga tatgcttcca ggtattcact ctgatttatt taaaacaata 900

tctagaccta gctctattgg actagaccgt tgggaaatga taaaattaga ggctattatg 960

1020

1080

1140 aaattagaaa atttaaatgt atctgatctt gaaattaaaa

gttataaatc aagccttgat atcaaaacaa ggttcatatc ttactaacct agtaatagaa 1200

1260

aataacttca cagatactac taaaattttt catgattcat tatttaattc agctaccgca 1320

gaaaactcta tgtttttaac aaaaatagca ccatacttac aagtaggttt tatgccagaa 1380

gctcgctcca caataagttt aagtggtcca ggagcttatg cgtcagctta ctatgatttc 1440

ataaatttac aagaaaatac tatagaaaaa actttaaaag catcagattt aatagaattt 1500

1560

tttgatcaag caagtgcaaa atatcaattt gagaaatatg taagagatta tactggtgga 1620

tctctttctg aagacaatgg ggtagacttt aataaaaata ctgccctcga caaaaactat 1680

ttattaaata ataaaattcc atcaaacaat gtagaagaag ctggaagtaa aaattatgtt 1740

1800

tctaaaaatc ctaaaaatag tattattata caacgaaata tgaatgaaag tgcaaaaagc 1860

tactttttaa gtgatgatgg agaatctatt ttagaattaa ataaatatag gatacctgaa 1920

agattaaaaa ataaggaaaa agtaaaagta acctttattg gacatggtaa agatgaattc 1980

aacacaagcg aatttgctag attaagtgta gattcacttt ccaatgagat aagttcattt 2040

ttagatacca taaaattaga tatatcacct aaaaatgtag aagtaaactt acttggatgt 2100

aatatgttta gttatgattt taatgttgaa gaaacttatc ctgggaagtt gctattaagt 2160

attatggaca aaattacttc cactttacct gatgtaaata aaaattctat tactatagga 2220

gcaaatcaat atgaagtaag aattaatagt gagggaagaa aagaacttct ggctcactca 2280

ggtaaatgga taaataaaga agaagctatt atgagcgatt tatctagtaa agaatacatt 2340

ttttttgatt ctatagataa taagctaaaa gcaaagtcca agaatattcc aggattagca 2400

tcaatatcag aagatataaa aacattatta cttgatgcaa gtgttagtcc tgatacaaaa 2460

tttattttaa ataatcttaa gcttaatatt gaatcttcta ttggggatta catttattat 2520

2580

ttcaatctac ttgaaaatgt atctgatgaa ttatatgaat taaaaaaatt aaataatcta 2640

gatgagaagt atttaatatc ttttgaagat atctcaaaaa ataattcaac ttactctgta 2700

agatttatta acaaaagtaa tggtgagtca gtttatgtag aaacagaaaa agaaattttt 2760

2820

2880

ttaaacgcag cattctttat tcaatcatta atagattata gtagcaataa agatgtactg 2940

aatgatttaa gtacctcagt taaggttcaa ctttatgctc aactatttag tacaggttta 3000

aatactatat atgactctat ccaattagta aatttaatat caaatgcagt aaatgatact 3060

ataaatgtac tacctacaat aacagagggg atacctattg tatctactat attagacgga 3120

ataaacttag gtgcagcaat taaggaatta ctagacgaac atgacccatt actaaaaaaa 3180

gaattagaag ctaaggtggg tgttttagca ataaatatgt cattatctat agctgcaact 3240

gtagcttcaa ttgttggaat aggtgctgaa gttactattt tcttattacc tatagctggt 3300

atatctgcag gaataccttc attagttaat aatgaattaa tattgcatga taaggcaact 3360

tcagtggtaa actattttaa tcatttgtct gaatctaaaa aatatggccc tcttaaaaca 3420

3480

aataattcga taaaactagg aacatgtaat atattagcaa tggagggggg atcaggacac 3540

acagtgactg gtaatataga tcactttttc tcatctccat ctataagttc tcatattcct 3600

3660

ataatgatgt tacctaatgc tccttcaaga gtgttttggt gggaaactgg agcagttcca 3720

3780

ccaggtaaat tttactggag attctatgct tttttcgatt atgcaataac tacattaaaa 3840

ccagtttatg aagacactaa tattaaaatt aaactagata aagatactag aaacttcata 3900

atgccaacta taactactaa cgaaattaga aacaaattat cttattcatt tgatggagca 3960

ggaggaactt actctttatt attatcttca tatccaatat caacgaatat aaatttatct 4020

4080

ggtactatta aaaaaggaaa gttaataaaa gatgttttaa gtaaaattga tataaataaa 4140

aataaactta ttataggcaa tcaaacaata gatttttcag gcgatataga taataaagat 4200

agatatatat tcttgacttg tgagttagat gataaaatta gtttaataat agaaataaat 4260

cttgttgcaa aatcttatag tttgttattg tctggggata aaaattattt gatatccaat 4320

ttatctaata ctattgagaa aatcaatact ttaggcctag atagtaaaaa tatagcgtac 4380

aattacactg atgaatctaa taataaatat tttggagcta tatctaaaac aagtcaaaaa 4440

agcataatac attataaaaa agacagtaaa aatatattag aattttataa tgacagtaca 4500

ttagaattta acagtaaaga ttttattgct gaagatataa atgtatttat gaaagatgat 4560

attaatacta taacaggaaa atactatgtt gataataata ctgataaaag tatagatttc 4620

tctatttctt tagttagtaa aaatcaagta aaagtaaatg gattatattt aaatgaatcc 4680

gtatactcat cttaccttga ttttgtgaaa aattcagatg gacaccataa tacttctaat 4740

tttatgaatt tatttttgga caatataagt ttctggaaat tgtttggggtt tgaaaatata 4800

aattttgtaa tcgataaata ctttaccctt gttggtaaaa ctaatcttgg atatgtagaa 4860

acaataataa aaatatagat atatattttg gtgaatggaa aacatcgtca 4920

tctaaaagca ctatatttag cggaaatggt agaaatgttg tagtagagcc tatatataat 4980

cctgatacgg gtgaagatat atctacttca ctagattttt cctatgaacc tctctatgga 5040

atagatagat atataaataa agtattgata gcacctgatt tatatacaag tttaataaat 5100

attaatacca attattattc aaatgagtac taccctgaga ttatagttct taacccaaat 5160

acattccaca aaaaagtaaa tataaattta gatagttctt cttttgagta taaatggtct 5220

acagaaggaa gtgactttat tttagttaga tacttagaag aaagtaataa aaaaatatta 5280

caaaaaataa gaatcaaagg tatcttatct aatactcaat catttaataa aatgagtata 5340

gattttaaag atattaaaaa actatcatta ggatatataa tgagtaattt taaatcattt 5400

aattctgaaa atgaattaga tagagatcat ttaggattta aaataataga taataaaact 5460

tattactatg atgaagatag taaattagtt aaaggattaa tcaatataaa taattcatta 5520

ttctattttg atcctataga atttaactta gtaactggat ggcaaactat caatggtaaa 5580

aaatattatt ttgatataaa tactggagca gctttaacta gttataaaat tattaatggt 5640

aaacactttt attttaataa tgatggtgtg atgcagttgg gagtatttaa aggacctgat 5700

ggatttgaat attttgcacc tgccaatact caaaataata acatagaagg tcaggctata 5760

gtttatcaaa gtaaattctt aactttgaat ggcaaaaaat attattttga taataactca 5820

aaagcagtca ctggatggag aattattaac aatgagaaat attactttaa tcctaataat 5880

gctattgctg cagtcggatt gcaagtaatt gacaataata agtattattt caatcctgac 5940

actgctatca tctcaaaagg ttggcagact gttaatggta gtagatacta ctttgatact 6000

6060

6120

6180

ttaactttga atggtaaaaa atattacttt gataataact caaaagcagt taccggattg 6240

caaactattg atagtaaaaa atattacttt aatactaaca ctgctgaagc agctactgga 6300

tggcaaacta ttgatggtaa aaaatattac tttaatacta acactgctga agcagctact 6360

ggatggcaaa ctattgatgg taaaaaatat tactttaata ctaacactgc tatagcttca 6420

actggttata caattattaa tggtaaacat ttttatttta atactgatgg tattatgcag 6480

ataggagtgt ttaaaggacc taatggattt gaatattttg cacctgctaa tacggatgct 6540

6600

aaatattact ttggtagtga ctcaaaagca gttactggat ggagaattat taacaataag 6660

aaatattact ttaatcctaa taatgctatt gctgcaattc atctatgcac tataaataat 6720

6780

6840

aatactcaca ataataacat agaaggtcag 6900

gctatagttt accagaacaa attcttaact ttgaatggca aaaaatatta ttttgataat 6960

gactcaaaag cagttactgg atggcaaacc attgatggta aaaaatatta ctttaatctt 7020

aacactgctg aagcagctac tggatggcaa actattgatg gtaaaaaata ttactttaat 7080

cttaacactg ctgaagcagc tactggatgg caaactattg atggtaaaaa atattacttt 7140

aatactaaca ctttcatagc ctcaactggt tatacaagta ttaatggtaa acatttttat 7200

tttaatactg atggtattat gcagatagga gtgtttaaag gacctaatgg atttgaatac 7260

tttgcacctg ctaatacgga tgctaacaac atagaaggtc aagctatact ttaccaaaat 7320

aaattcttaa ctttgaatgg taaaaaatat tactttggta gtgactcaaa agcagttacc 7380

ggactgcgaa ctattgatgg taaaaaatat tactttaata ctaacactgc tgttgcagtt 7440

actggatggc aaactattaa tggtaaaaaa tactacttta atactaacac ttctatagct 7500

tcaactggtt atacaattat tagtggtaaa catttttatt ttaatactga tggtattatg 7560

cagataggag tgtttaaagg acctgatgga tttgaatact ttgcacctgc taatacagat 7620

7680

aatatatatt attttggtaa taattcaaaa gcggctactg gttgggtaac tattgatggt 7740

aatagatatt acttcgagcc taatacagct atgggtgcga atggttataa aactattgat 7800

aataaaaatt tttactttag aaatggttta cctcagatag gagtgtttaa agggtctaat 7860

ggatttgaat actttgcacc tgctaatacg gatgctaaca atatagaagg tcaagctata 7920

cgttatcaaa atagattcct acatttactt ggaaaaatat attactttgg taataattca 7980

aaagcagtta ctggatggca aactattaat ggtaaagtat attactttat gcctgatact 8040

gctatggctg cagctggtgg acttttcgag attgatggtg ttatatattt ctttggtgtt 8100

gatggagtaa aagcccctgg gatatatggc taa 8133

<210> 21

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 21

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr

180 185 190

Gln Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser

1115 1120 1125

Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu

1325 1330 1335

Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Ser Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys

1490 1495 1500

Pro Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys

1715 1720 1725

Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly

1760 1765 1770

Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu

1865 1870 1875

Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe

1925 1930 1935

Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp

1940 1945 1950

Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile

2090 2095 2100

Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln

2105 2110 2115

Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp

2255 2260 2265

Gly Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe

2270 2275 2280

Tyr Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 22

<211> 7101

<212> DNA

<213> Clostridium difficile

<400> 22

atgagtttag ttaatagaaa acagttagaa aaaatggcaa atgtaagatt tcgtgttcag 60

gaagatgaat atgtagcaat attggatgct ttagaagaat atcataatat gtcagagaat 120

actgtagtcg aaaaatattt aaaattaaaa gatataaata gtttaacaga tattatata 180

gatacatata aaaagtctgg tagaaataaa gccttaaaaa aatttaagga atacctagtt 240

acagaagtat tagagctaaa gaataataat ttaactccag ttgagaaaaa tttacatttt 300

360

gtaaatagtg attataatgt taatgttttt tatgatagta atgcattttt gataaacaca 420

ttgaaaaaaa ctatagtaga atcagcaaca aatgatacac ttgaatcatt tagagaaaac 480

ttaaatgacc ctagatttga ctataataaa ttttacagaa aacgtatgga gataatctat 540

gataagcaga aaaatttcat aaattactat aaaactcaaa gagaagaaaa tcctgacctt 600

ataattgatg atattgtaaa gatatatctt tcaaacgagt attcaaagga tatagatgaa 660

cttaattcct atattgaaga gtcattaaat aaagttacag aaaatagtgg gaatgatgtt 720

agaaactttg aagaatttaa aggtggagag tcattcaaat tatatgaaca agagttggta 780

gaaagatgga atttggcagc tgcttctgac atattaagaa tatctgcctt aaaagaagtt 840

ggtggtgtat atttagatgt tgatatgtta cggaatac aaccagacct atttgagtct 900

atagagaaac ctagttcagt aacagtggat ttttgggaaa tggtaaaatt agaagctata 960

atgaaataca aagaatacat accaggatat acttcagagc attttgatat gttggatgaa 1020

gaagttcaaa gtagttttga atctgttcta gcttctaagt cagataagtc agaaatattc 1080

tcatcacttg gcgatatgga ggcatcacca ctagaagtta aaattgcatt taatagtaaa 1140

ggtattataa atcaaggact aatttctgtg aaagactcat attgtagcaa tttaatagta 1200

1260

gataacgatt tcaatactac aacgaatgct tttattgata gtataatggc tgaagctaat 1320

gcagataatg gtagatttat gatggaacta ggaaagtatt taagagttgg tttcttccca 1380

gatgttaaaa ctactattaa cttaagtggc cctgaagcat atgcggcagc ttatcaagat 1440

ttattaatgt ttaaagaagg tagtatgaat atccatttga tagaagctga cttaagaaac 1500

tttgaaatct ctaaaactaa tatttctcaa tcaactgaac aagaaatggc tagcttatgg 1560

tcatttgacg atgcaagagc taaagctcaa tttgaagaat acaaaaaaaa ttactttgaa 1620

ggttctcttg gagaagatga caatcttgac ttttctcaaa atacagtagt tgacaaggag 1680

aaaaaatatc ttcattagca agaagttcag agagaggata tatacactat 1740

1800

actccttatg atagtgtact gtttcagaaa aatatagaag attcagaaat tgcatattat 1860

tataatcctg gagatggtga aatacaagaa atagacaagt ataaaattcc aagtataatt 1920

tctgatagac ctaagattaa attaacattt attggtcatg gtaaagatga atttaatact 1980

gatatatttg caggtcttga tgtagattca ttatccacag aaatagaaac agcaatagat 2040

ttagctaaag aggatatttc tcctaagtca atagaaataa acttactggg atgtaacatg 2100

tttagctatt ctgtaaatgt agaggagact tatcctggga aattattact tagagttaaa 2160

gataaagtat cagaattaat gccatctata agtcaagact ctattatagt aagtgcaaat 2220

caatatgaag ttagaataaa tagtgaagga agaagaat tattggatca ttctggtgaa 2280

tggataaata aagaagaaag tattataaag gatatttcat caaaagaata tatatcattt 2340

aatcctaaag aaaataaaat tatagtaaaa tctaaaaatt tacctgaatt atctacatta 2400

ttctaattca agtgatattg aactagaaga aaaagtaatg 2460

ttagcagaat gtgagataaa tgttatttca aatatagata cacaagtggt agaaggaagg 2520

attgaagaag ctaaaagctt aacttctgac tctattaatt atataaagaa tgaatttaaa 2580

ctaatagaat ctatttctga tgcactatac gatttaaaac aacagaatga attagaagag 2640

2700

attgataaag aaactggaga atctatattt gtagaaactg aaaaggcaat attctctgaa 2760

tatgctaatc atataactga agagatttct aagataaaag gtactatatt tgatactgta 2820

aatggtaagt tagtaaaaaa agtaaattta gatgctacac atgaagtgaa tactttaaat 2880

gctgcatttt ttatacaatc attaatagaa tataatagtt ctaaagaatc tcttagtaat 2940

ttaagtgtag caatgaaagt tcaagtttat gctcaattat ttagtactgg tttaaatact 3000

attacagatg cagccaaagt tgttgaatta gtatcaactg cattagatga aactatagat 3060

ttacttccta cattatctga aggattacct gtaattgcaa ctatcataga tggtgtaagt 3120

ttaggtgcag caatcaaaga gctaagtgaa acaagtgacc cattattaag acaagaaata 3180

gaagctaaga taggtataat ggcagtaaat ttaacagcag ctacaactgc aatcattact 3240

tcatctttag gaatagctag tggatttagt atacttttag ttcctttagc aggaatttca 3300

3360

gtagattatt ttagtcatat atcattagct gagtctgaag gagcatttac ttcattagat 3420

3480

tcaataactt taggtaaatg tgaaatctgg agaatggaag gtggctcagg tcatactgta 3540

actgatgata tagatcactt cttttcagca ccatcaataa catatagaga gccacactta 3600

3660

gtattaccta atgctccaaa tagagtattt gcttgggaaa caggatggac accaggttta 3720

agaagcttag aaaatgatgg cacaaaactg ttagaccgta taagagataa ctatgaaggt 3780

3840

agatatgaag atactaatat aagaataaat ttagatagta atactagaag ctttatagtc 3900

ccagtgataa ctacagaata tataagagag aaattatcat attcttttta tggttctgga 3960

ggaacttatg cattatctct ttctcaatac aatatgaata taaacataga attaaatgaa 4020

aatgatactt gggttataga tgtcgacaat gtcgtaagag atgtcactat agaatctgat 4080

4140

aaaattattt tagataatca tgaaattaat ttctctggaa cattaaatgg aggtaatgga 4200

tttgtatctt taacattctc aatcttagaa ggaataaatg cagttataga agttgattta 4260

ttatctaaat catataaagt tcttatttct ggtgaactaa aaacattgat ggcaaattca 4320

aattctgttc aacagaaaat agattatata ggattgaaca gcgaattaca aaaaaatata 4380

4440

gaaggtttat ttgtatctga attatctgat gtagttctta taagtaaagt ttatatggac 4500

aatagtaaac ctctatttgg atattgtagt aatgatttga aagatgttaa agtcataact 4560

aaagatgacg ttattatatt aacaggatat tatttaaaag atgatataaa aatctctctt 4620

tcttttacta tacaagatga aaatactata aaattaaatg gagtatattt agatgaaaat 4680

ggagtagctg aaatattgaa atttatgaat aaaaaaggta gtacaaatac ttcagattct 4740

ttaatgagct ttttagaaag tatgaatata aaaagtattt tcataaattc cttacaatct 4800

aatactaagc ttatattaga tactaatttt ataataagtg gtactacttc tattggtcaa 4860

tttgagttta tttgtgataa agataataat atacaaccat atttcattaa gtttaataca 4920

ctagaaacta aatatactct atatgtaggt aatagacaaa atatgatagt agaaccaaat 4980

tatgatttag atgattctgg agatatatct tcaactgtca ttaatttttc tcagaaatac 5040

ctttatggaa tagacagttg tgttaataaa gttataattt cgccaaatat atatacagat 5100

gaaataaaca taacacctat atatgaagca aataatactt atccagaagt gattgtatta 5160

5220

gtatggagta atgatggaag tgattttatt cttatgtcaa ctgatgaaga gaacaaggta 5280

tcacaagtta aaataagatt tactaatgtt tttaaaggta atactatatc agataagata 5340

tcttttaatt ttagtgataa gcaagatgta tctataaata aagttatttc aacatttaca 5400

ccttcatatt atgtggaagg attacttaat tatgatttag gtctgatttc tttatacaat 5460

gagaaatttt atattaataa ctttggaatg atggtgtctg gattagtata tattaatgat 5520

tcattatatt atttcaagcc accaataaag aacttgataa ctggatttac aactataggt 5580

gatgataaat actactttaa tccagataat ggtggagctg cttcagtcgg agaaacaata 5640

attgatggca aaaactacta cttcagccaa aatggagtgt tacaaacagg tgtatttagt 5700

acagaagatg gatttaaata ttttgctcca gcagatacac ttgatgaaaa tctagagggg 5760

gaagcaattg attttactgg caaactaact attgatgaaa atgtttatta ttttggagat 5820

aattatagag cagctataga atggcaaaca ttagatgatg aagtgtacta ttttagtaca 5880

gatacaggta gagcttttaa agggctaaat caaataggtg atgataaatt ctatttcaac 5940

tctgatggta ttatgcaaaa aggatttgtt aatataaatg ataagacatt ctattttgat 6000

6060

gagaatggag aaatgcaaat aggagtattt aatacagcag atggatttaa atattttgct 6120

catcatgatg aagatttagg aaatgaagaa ggtgaagcac tttcatattc tggtatactt 6180

6240

gatttagaag atggttcaaa atattacttt gatgaagata cagcagaagc atatataggt 6300

atctcaataa ttaatgatgg taaatattat tttaatgatt ctggaatcat gcaaattgga 6360

6420

6480

gtatttgaca cttcagatgg atataaatac tttgcaccag ctaatactgt aaatgataat 6540

atctatggac aagcagttga atatagtggt ttagttagag ttggtgaaga tgtatattat 6600

6660

aaatattatt tcgatccaga aactaaaaaa gcatataaag gtattaatgt aattgatgat 6720

6780

aatcattact attttaatga agatggtatt atgcaatatg gttatctaaa tatagaagat 6840

aagacgttct actttagtga agatggtatt atgcagattg gagtatttaa tacaccagat 6900

ggatttaaat attttgcaca tcaaaatact ttagatgaga attttgagggg agaatcaata 6960

aactatactg gttggttaga tttagatgaa aagagatatt attttacaga tgaatatatt 7020

gcagcaactg gttcagttat tattgatggt gaggagtatt attttgatcc tgatacagct 7080

caattagtga ttagtgaata g 7101

<210> 23

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 23

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr

180 185 190

Gln Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser

1115 1120 1125

Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu

1325 1330 1335

Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Ser Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys

1490 1495 1500

Pro Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys

1715 1720 1725

Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly

1760 1765 1770

Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu

1865 1870 1875

Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe

1925 1930 1935

Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp

1940 1945 1950

Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile

2090 2095 2100

Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln

2105 2110 2115

Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp

2255 2260 2265

Gly Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe

2270 2275 2280

Tyr Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 24

<211> 7101

<212> DNA

<213> Clostridium difficile

<400> 24

atgagtttag ttaatagaaa acagttagaa aaaatggcaa atgtaagatt tcgtgttcag 60

gaagatgaat atgtagcaat attggatgct ttagaagaat atcataatat gtcagagaat 120

actgtagtcg aaaaatattt aaaattaaaa gatataaata gtttaacaga tattatata 180

gatacatata aaaagtctgg tagaaataaa gccttaaaaa aatttaagga atacctagtt 240

acagaagtat tagagctaaa gaataataat ttaactccag ttgagaaaaa tttacatttt 300

360

gtaaatagtg attataatgt taatgttttt tatgatagta atgcattttt gataaacaca 420

ttgaaaaaaa ctatagtaga atcagcaaca aatgatacac ttgaatcatt tagagaaaac 480

ttaaatgacc ctagatttga ctataataaa ttttacagaa aacgtatgga gataatctat 540

gataagcaga aaaatttcat aaattactat aaaactcaaa gagaagaaaa tcctgacctt 600

ataattgatg atattgtaaa gatatatctt tcaaacgagt attcaaagga tatagatgaa 660

cttaattcct atattgaaga gtcattaaat aaagttacag aaaatagtgg gaatgatgtt 720

agaaactttg aagaatttaa aggtggagag tcattcaaat tatatgaaca agagttggta 780

gaaagatgga atttggcagc tgcttctgac atattaagaa tatctgcctt aaaagaagtt 840

ggtggtgtat atttagatgt tgatatgtta cggaatac aaccagacct atttgagtct 900

atagagaaac ctagttcagt aacagtggat ttttgggaaa tggtaaaatt agaagctata 960

atgaaataca aagaatacat accaggatat acttcagagc attttgatat gttggatgaa 1020

gaagttcaaa gtagttttga atctgttcta gcttctaagt cagataagtc agaaatattc 1080

tcatcacttg gcgatatgga ggcatcacca ctagaagtta aaattgcatt taatagtaaa 1140

ggtattataa atcaaggact aatttctgtg aaagactcat attgtagcaa tttaatagta 1200

1260

gataacgatt tcaatactac aacgaatgct tttattgata gtataatggc tgaagctaat 1320

gcagataatg gtagatttat gatggaacta ggaaagtatt taagagttgg tttcttccca 1380

gatgttaaaa ctactattaa cttaagtggc cctgaagcat atgcggcagc ttatcaagat 1440

ttattaatgt ttaaagaagg tagtatgaat atccatttga tagaagctga cttaagaaac 1500

tttgaaatct ctaaaactaa tatttctcaa tcaactgaac aagaaatggc tagcttatgg 1560

tcatttgacg atgcaagagc taaagctcaa tttgaagaat acaaaaaaaa ttactttgaa 1620

ggttctcttg gagaagatga caatcttgac ttttctcaaa atacagtagt tgacaaggag 1680

aaaaaatatc ttcattagca agaagttcag agagaggata tatacactat 1740

1800

actccttatg atagtgtact gtttcagaaa aatatagaag attcagaaat tgcatattat 1860

tataatcctg gagatggtga aatacaagaa atagacaagt ataaaattcc aagtataatt 1920

tctgatagac ctaagattaa attaacattt attggtcatg gtaaagatga atttaatact 1980

gatatatttg caggtcttga tgtagattca ttatccacag aaatagaaac agcaatagat 2040

ttagctaaag aggatatttc tcctaagtca atagaaataa acttactggg atgtaacatg 2100

tttagctatt ctgtaaatgt agaggagact tatcctggga aattattact tagagttaaa 2160

gataaagtat cagaattaat gccatctata agtcaagact ctattatagt aagtgcaaat 2220

caatatgaag ttagaataaa tagtgaagga agaagaat tattggatca ttctggtgaa 2280

tggataaata aagaagaaag tattataaag gatatttcat caaaagaata tatatcattt 2340

aatcctaaag aaaataaaat tatagtaaaa tctaaaaatt tacctgaatt atctacatta 2400

ttctaattca agtgatattg aactagaaga aaaagtaatg 2460

ttagcagaat gtgagataaa tgttatttca aatatagata cacaagtggt agaaggaagg 2520

attgaagaag ctaaaagctt aacttctgac tctattaatt atataaagaa tgaatttaaa 2580

ctaatagaat ctatttctga tgcactatac gatttaaaac aacagaatga attagaagag 2640

2700

attgataaag aaactggaga atctatattt gtagaaactg aaaaggcaat attctctgaa 2760

tatgctaatc atataactga agagatttct aagataaaag gtactatatt tgatactgta 2820

aatggtaagt tagtaaaaaa agtaaattta gatgctacac atgaagtgaa tactttaaat 2880

gctgcatttt ttatacaatc attaatagaa tataatagtt ctaaagaatc tcttagtaat 2940

ttaagtgtag caatgaaagt tcaagtttat gctcaattat ttagtactgg tttaaatact 3000

attacagatg cagccaaagt tgttgaatta gtatcaactg cattagatga aactatagat 3060

ttacttccta cattatctga aggattacct gtaattgcaa ctatcataga tggtgtaagt 3120

ttaggtgcag caatcaaaga gctaagtgaa acaagtgacc cattattaag acaagaaata 3180

gaagctaaga taggtataat ggcagtaaat ttaacagcag ctacaactgc aatcattact 3240

tcatctttag gaatagctag tggatttagt atacttttag ttcctttagc aggaatttca 3300

3360

gtagattatt ttagtcatat atcattagct gagtctgaag gagcatttac ttcattagat 3420

3480

tcaataactt taggtaaatg tgaaatctgg agaatggaag gtggctcagg tcatactgta 3540

actgatgata tagatcactt cttttcagca ccatcaataa catatagaga gccacactta 3600

3660

gtattaccta atgctccaaa tagagtattt gcttgggaaa caggatggac accaggttta 3720

agaagcttag aaaatgatgg cacaaaactg ttagaccgta taagagataa ctatgaaggt 3780

3840

agatatgaag atactaatat aagaataaat ttagatagta atactagaag ctttatagtc 3900

ccagtgataa ctacagaata tataagagag aaattatcat attcttttta tggttctgga 3960

ggaacttatg cattatctct ttctcaatac aatatgaata taaacataga attaaatgaa 4020

aatgatactt gggttataga tgtcgacaat gtcgtaagag atgtcactat agaatctgat 4080

4140

aaaattattt tagataatca tgaaattaat ttctctggaa cattaaatgg aggtaatgga 4200

tttgtatctt taacattctc aatcttagaa ggaataaatg cagttataga agttgattta 4260

ttatctaaat catataaagt tcttatttct ggtgaactaa aaacattgat ggcaaattca 4320

aattctgttc aacagaaaat agattatata ggattgaaca gcgaattaca aaaaaatata 4380

4440

gaaggtttat ttgtatctga attatctgat gtagttctta taagtaaagt ttatatggac 4500

aatagtaaac ctctatttgg atattgtagt aatgatttga aagatgttaa agtcataact 4560

aaagatgacg ttattatatt aacaggatat tatttaaaag atgatataaa aatctctctt 4620

tcttttacta tacaagatga aaatactata aaattaaatg gagtatattt agatgaaaat 4680

ggagtagctg aaatattgaa atttatgaat aaaaaaggta gtacaaatac ttcagattct 4740

ttaatgagct ttttagaaag tatgaatata aaaagtattt tcataaattc cttacaatct 4800

aatactaagc ttatattaga tactaatttt ataataagtg gtactacttc tattggtcaa 4860

tttgagttta tttgtgataa agataataat atacaaccat atttcattaa gtttaataca 4920

ctagaaacta aatatactct atatgtaggt aatagacaaa atatgatagt agaaccaaat 4980

tatgatttag atgattctgg agatatatct tcaactgtca ttaatttttc tcagaaatac 5040

ctttatggaa tagacagttg tgttaataaa gttataattt cgccaaatat atatacagat 5100

gaaataaaca taacacctat atatgaagca aataatactt atccagaagt gattgtatta 5160

5220

gtatggagta atgatggaag tgattttatt cttatgtcaa ctgatgaaga gaacaaggta 5280

tcacaagtta aaataagatt tactaatgtt tttaaaggta atactatatc agataagata 5340

tcttttaatt ttagtgataa gcaagatgta tctataaata aagttatttc aacatttaca 5400

ccttcatatt atgtggaagg attacttaat tatgatttag gtctgatttc tttatacaat 5460

gagaaatttt atattaataa ctttggaatg atggtgtctg gattagtata tattaatgat 5520

tcattatatt atttcaagcc accaataaag aacttgataa ctggatttac aactataggt 5580

gatgataaat actactttaa tccagataat ggtggagctg cttcagtcgg agaaacaata 5640

attgatggca aaaactacta cttcagccaa aatggagtgt tacaaacagg tgtatttagt 5700

acagaagatg gatttaaata ttttgctcca gcagatacac ttgatgaaaa tctagagggg 5760

gaagcaattg attttactgg caaactaact attgatgaaa atgtttatta ttttggagat 5820

aattatagag cagctataga atggcaaaca ttagatgatg aagtgtacta ttttagtaca 5880

gatacaggta gagcttttaa agggctaaat caaataggtg atgataaatt ctatttcaac 5940

tctgatggta ttatgcaaaa aggatttgtt aatataaatg ataagacatt ctattttgat 6000

6060

gagaatggag aaatgcaaat aggagtattt aatacagcag atggatttaa atattttgct 6120

catcatgatg aagatttagg aaatgaagaa ggtgaagcac tttcatattc tggtatactt 6180

6240

gatttagaag atggttcaaa atattacttt gatgaagata cagcagaagc atatataggt 6300

atctcaataa ttaatgatgg taaatattat tttaatgatt ctggaatcat gcaaattgga 6360

6420

6480

gtatttgaca cttcagatgg atataaatac tttgcaccag ctaatactgt aaatgataat 6540

atctatggac aagcagttga atatagtggt ttagttagag ttggtgaaga tgtatattat 6600

6660

aaatattatt tcgatccaga aactaaaaaa gcatataaag gtattaatgt aattgatgat 6720

6780

aatcattact attttaatga agatggtatt atgcaatatg gttatctaaa tatagaagat 6840

aagacgttct actttagtga agatggtatt atgcagattg gagtatttaa tacaccagat 6900

ggatttaaat attttgcaca tcaaaatact ttagatgaga attttgagggg agaatcaata 6960

aactatactg gttggttaga tttagatgaa aagagatatt attttacaga tgaatatatt 7020

7080 gcagcaactg gttcagttat tattgatggt gaggagtatt

caattagtga ttagtgaata g 7101

<210> 25

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 25

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 26

<211> 7101

<212> DNA

<213> Clostridium difficile

<400> 26

atgagtttag ttaatagaaa acagttagaa aaaatggcaa atgtaagatt tcgtactcaa 60

gaagatgaat atgttgcaat attggatgct ttagaagaat atcataatat gtcagagaat 120

actgtagtcg aaaaatattt aaaattaaaa gatataaata gtttaacaga tattatata 180

gatacatata aaaaatctgg tagaaataaa gccttaaaaa aatttaagga atatctagtt 240

acagaagtat tagagctaaa gaataataat ttaactccag ttgagaaaaa tttacatttt 300

gtttggattg gaggtcaaat 360

gtaaatagtg attataatgt taatgttttt tatgatagta atgcattttt gataaacaca 420

ttgaaaaaaa ctgtagtaga atcagcaata aatgatacac ttgaatcatt tagagaaaac 480

ttaaatgacc ctagatttga ctataataaa ttcttcagaa aacgtatgga aataatttat 540

gataaacaga aaaatttcat aaactactat aaagctcaaa gagaagaaaa tcctgaactt 600

ataattgatg atattgtaaa gacatatctt tcaaatgagt attcaaagga gatagatgaa 660

cttaatacct atattgaaga atccttaaat aaaattacac agaatagtgg aaatgatgtt 720

agaaactttg aagaatttaa aaatggagag tcattcaact tatatgaaca agagttggta 780

gaaaggtgga atttagctgc tgcttctgac atattaagaa tatctgcatt aaaagaaatt 840

ggtggtatgt atttagatgt tgatatgtta cggaatac aaccagactt atttgagtct 900

atagagaaac ctagttcagt aacagtggat ttttgggaaa tgacaaagtt agaagctata 960

atgaaataca aagaatatat accagaatat acctcagaac attttgacat gttagacgaa 1020

gaagttcaaa gtagttttga atctgttcta gcttctaagt cagataaatc agaaatattc 1080

tcatcacttg gtgatatgga ggcatcacca ctagaagtta aaattgcatt taatagtaag 1140

ggtattataa atcaagggct aatttctgtg aaagactcat attgtagcaa tttaatagta 1200

1260

gataatgatt ttaatactac aacgaatacc tttattgata gtataatggc tgaagctaat 1320

gcagataatg gtagatttat gatggaacta ggaaagtatt taagagttgg tttcttccca 1380

gatgttaaaa ctactattaa cttaagtggc cctgaagcat atgcggcagc ttatcaagat 1440

ttattaatgt ttaaagaagg cagtatgaat atccatttga tagaagctga tttaagaaac 1500

tttgaaatct ctaaaactaa tatttctcaa tcaactgaac aagaaatggc tagcttatgg 1560

1620

ggttctcttg gtgaagatga taatcttgat ttttctcaaa atatagtagt tgacaaggag 1680

aaaaaatatc ttcattagca agaagttcag agagaggata tatacactat 1740

1800

actccttatg atagtgtact gtttcagaaa aatatagaag attcagaaat tgcatattat 1860

tataatcctg gagatggtga aatacaagaa atagacaagt ataaaattcc aagtataatt 1920

tctgatagac ctaagattaa attaacattt attggtcatg gtaaagatga atttaatact 1980

gatatatttg caggttttga tgtagattca ttatccacag aaatagaagc agcaatagat 2040

ttagctaaag aggatatttc tcctaagtca atagaaataa atttattagg atgtaatatg 2100

tttagctact ctatcaacgt agaggagact tatcctggaa aattattact taaagttaaa 2160

gataaaatat cagaattaat gccatctata agtcaagact ctattatagt aagtgcaaat 2220

caatatgaag ttagaataaa tagtgaagga agaagaat tattggatca ttctggtgaa 2280

tggataaata aagaagaaag tattataaag gatatttcat caaaagaata tatatcattt 2340

aatcctaaag aaaataaaat tacagtaaaa tctaaaaatt tacctgagct atctacatta 2400

ttacaagaaa ttagaaataa ttctaattca agtgatattg aactagaaga aaaagtaatg 2460

2520

attgaagaag ctaagaattt aacttctgac tctattaatt atataaaaga tgaatttaaa 2580

ctaatagaat ctatttctga tgcactatgt gacttaaaac aacagaatga attagaagat 2640

2700

attaataaag aaactggaga atctatattt gtagaaactg aaaaaacaat attctctgaa 2760

tatgctaatc atataactga agagatttct aagataaaag gtactatatt tgatactgta 2820

aatggtaagt tagtaaaaaa agtaaattta gatactacacacgaagtaaa tactttaaat 2880

gctgcatttt ttatacaatc attaatagaa tataatagtt ctaaagaatc tcttagtaat 2940

ttaagtgtag caatgaaagt ccaagtttac gctcaattat ttagtactgg tttaaatact 3000

3060

ttacttccta cattatctga aggattacct ataattgcaa ctattataga tggtgtaagt 3120

ttaggtgcag caatcaaaga gctaagtgaa acgagtgacc cattattaag acaagaaata 3180

gaagctaaga taggtataat ggcagtaaat ttaacaacag ctacaactgc aatcattact 3240

tcatctttgg ggatagctag tggatttagt atacttttag ttcctttagc aggaatttca 3300

3360

3420

3480

tcaatagttt taggtaaatg tgaaatctgg agaatggaag gtggttcagg tcatactgta 3540

actgatgata tagatcactt cttttcagca ccatcaataa catatagaga gccacactta 3600

3660

gtattaccta atgctccaaa tagagtattt gcttgggaaa caggatggac accaggttta 3720

agaagcttag aaaatgatgg cacaaaactg ttagaccgta taagagataa ctatgaaggt 3780

3840

agatatgaag atactaatat aagaataaat ttagatagta atactagaag ttttatagtt 3900

ccaataataa ctacagaata tataagagaa aaattatcat attctttcta tggttcagga 3960

ggaacttatg cattgtctct ttctcaatat aatatgggta taaatataga attaagtgaa 4020

4080

aaaattaaaa aaggtgattt aatagaaggt attttatcta cactaagtat tgaagagaat 4140

aaaattatct taaatagcca tgagattaat ttttctggtg aggtaaatgg aagtaatgga 4200

tttgtttctt taacattttc aattttagaa ggaataaatg caattataga agttgattta 4260

ttatctaaat catataaatt acttatttct ggcgaattaa aaatattgat gttaaattca 4320

aatcatattc aacagaaaat agattatata ggattcaata gcgaattaca gaaaaatata 4380

ccatatagct ttgtagatag tgaaggaaaa gagaatggtt ttattaatgg ttcaacaaaa 4440

gaaggtttat ttgtatctga attacctgat gtagttctta taagtaaggt ttatatggat 4500

gatagtaagc cttcatttgg atattatagt aataatttga aagatgtcaa agttataact 4560

aaagataatg ttaatatatt aacaggttat tatcttaagg atgatataaa aatctctctt 4620

4680

ggagtagctg agattttgaa gttcatgaat agaaaaggta atacaaatac ttcagattct 4740

ttaatgagct ttttagaaag tatgaatata aaaagtattt tcgttaattt cttacaatct 4800

aatattaagt ttatattaga tgctaatttt ataataagtg gtactacttc tattggccaa 4860

tttgagttta tttgtgatga aaatgataat atacaaccat atttcattaa gtttaataca 4920

ctagaaacta attatacttt atatgtagga aatagacaaa atatgatagt ggaaccaaat 4980

tcaatttctc tcaaaagtat 5040

5100

gaaataaata taacgcctgt atatgaaaca aataatactt atccagaagt tattgtatta 5160

gatgcaaatt atataaatga aaaaataaat gttaatatca atgatctatc tatacgatat 5220

gtatggagta atgatggtaa tgattttatt cttatgtcaa ctagtgaaga aaataaggtg 5280

tcacaagtta aaataagatt cgttaatgtt tttaaagata agactttggc aaataagcta 5340

tcttttaact ttagtgataa acaagatgta cctgtaagtg aaataatctt atcatttaca 5400

ccttcatatt atgaggatgg attgattggc tatgatttgg gtctagtttc tttatataat 5460

gagaaatttt atattaataa ctttggaatg atggtatctg gattaatata tattaatgat 5520

tcattatatt attttaaacc accagtaaat aatttgataa ctggatttgt gactgtaggc 5580

gatgataaat actactttaa tccaattaat ggtggagctg cttcaattgg agagacaata 5640

attgatgaca aaaattatta tttcaaccaa agtggagtgt tacaaacagg tgtatttagt 5700

acagaagatg gatttaaata ttttgcccca gctaatacac ttgatgaaaa cctagaagga 5760

gaagcaattg attttactgg aaaattaatt attgacgaaa atatttatta ttttgatgat 5820

aattatagag gagctgtaga atggaaagaa ttagatggtg aaatgcacta ttttagccca 5880

gaaacaggta aagcttttaa aggtctaaat caaataggtg attataaata ctatttcaat 5940

tctgatggag ttatgcaaaa aggatttgtt agtataaatg ataataaaca ctattttgat 6000

gattctggtg ttatgaaagt aggttacact gaaatagatg gcaagcattt ctactttgct 6060

6120

catcataatg aagatttagg aaatgaagaa ggtgaagaaa tctcatattc tggtatatta 6180

6240

gatttagagg atggttcaaa gtattatttt gatgaagata cagcagaagc atatataggt 6300

ttgtcattaa taaatgatgg tcaatattat tttaatgatg atggaattat gcaagttgga 6360

tttgtcacta taaatgataa agtcttctac ttctctgact ctggaattat agaatctgga 6420

gtacaaaaca tagatgacaa ttatttctat tagatgata atggtatagt tcaaattggt 6480

gtatttgata cttcagatgg atataaatat tttgcacctg ctaatactgt aaatgataat 6540

atttacggac aagcagttga atatagtggt ttagttagag ttggggaaga tgtatattat 6600

6660

aaatattatt tcaatccaga aactaaaaaa gcatgcaaag gtattaattt aattgatgat 6720

ataaaatatt attttgatga gaagggcata atgagaacgg gtcttatatc atttgaaaat 6780

aataattatt actttaatga gaatggtgaa atgcaatttg gttatataaa tatagaagat 6840

aagatgttct attttggtga agatggtgtc atgcagattg gagtatttaa tacaccagat 6900

ggatttaaat actttgcaca tcaaaatact ttggatgaga attttgaggg agaatcaata 6960

aactatactg gttggttaga tttagatgaa aagagatatt attttacaga tgaatatatt 7020

gcagcaactg gttcagttat tattgatggt gaggagtatt attttgatcc tgatacagct 7080

caattagtga ttagtgaata g 7101

<210> 27

<211> 26039

<212> DNA

<213> Clostridium difficile

<400> 27

agctagtctt ggtgtattgt tagcaggatt ttttaatttg ccaattgaat tagttgcagc 60

cgttggctat gctagtgtct ttggtagtgc tacaaatact ttttttgcac ctgtatttat 120

aggggcagaa gtttttggat acagctattt accttatttc tttgtagtat gcgctatttc 180

aatatatttt aatatggata aatctattta ttcactacaa aaaatttcaa caaaacaata 240

aataaaacaa cataatgtat gattagaaga gaaagaatat tagagaaagg atagggtagg 300

360

aagaggataa agttacctaa cttattggga atgttactta caggaattat attaggtcca 420

tatgttttaa atttgattga taattcaata ctagatattt cttctgacct tagaaagatt 480

gcattgatta ttatattaac aagggctgga ttatctttag atataaacga tttgaagaaa 540

gtgggaagac ctgctgtact tatgtgcttt attccagcta cttttgaaat tatcggaatg 600

atagttttag caccaaagtt actaggcgtt tctatattgg aagcagcagt catgggtgca 660

gtagtaggag cagtttctcc tgcaattatt gtacctaaaa tgcttaaatt aatggaagaa 720

ggttatggta cagaaaaaag tattccacag atgcttttag caggaacttc tatagacgat 780

attttcgtaa ttgtgatgtt tacagtattc acaggattgg cacaaggaaa tagtatatca 840

gctattagtt ttttacaaat tccagtatca attatattag gtgtaatagc tggagcagtg 900

attggaatct gtttagcagt attttttaag aaggttcata tgagagattc tgctaaaggg 960

gtgttgcttt taagtatctc atttttaatg ataagtttag aaactgcttt aggggtatt 1020

gtgccatttt ctggattatt agcagttatg agtattggga ttttccttca gataaaatat 1080

cgtgtagttg caagaagatt gtctataaag tattcaaaac tatgggttgg cgctgaaatt 1140

ctcttgtttg ttttggtagg ggcaacagta gatataagtt atgcatttaa agcaggaatt 1200

ggagctgtaa ttttaatatt tggagttctt ttattccgta tgtaggagta ttcttctgcc 1260

ttattaagac aaatttgaca ataaaggaaa gattgttctg tatgattggc tatattccaa 1320

aggctacagt acaggcagca ataggaggtg taccacttgc aatggggatg gcatctggac 1380

aacttatttt gacgttagca gttctcgcta tacttataac tgcacctctt ggagcttttg 1440

gaattgatgt aacttataaa aaattattaa cttctgtaaa aggcgagagt aagtaaaaat 1500

1560

1620

1680

aagcggagtg ataactatgt gtttaaaaaa attatcaaaa ttagagttag ttattatgaa 1740

atttatttgg aatttagata taaaaaccaa ttcatatgag

agaacataat ttaccagaaa aagtagcttt aaaaacttta tcaaaactat caaagaaaaa 1860

tatgtattat acagttgcaa taaaagaaaa 1920

ggcatattta gagtttatat caagaaatgt gcaaaatctt ttgaagaata attttataag 1980

gaatttatta gtatcatttc acgaagagga gctaacagag gaaaagataa agtcgttaga 2040

aaactgggta gtaaattggg aagaagctta tgtataaatg ttattatttt tattacaatt 2100

tagataattt tggttttgta agctctgcaa ctatttttag atggttgcag agtttatttt 2160

tattttttat tcccttaagc aatacttaaa agtaaacgca tttatattta ctaacttcaa 2220

ttacttctaa tacttaaatt actttttaaa aatattttga tatgtcatct ctatagtaat 2280

2340

catttgatta aaaataacaa aatattaaat aattctactc tgatagtttg ttaaaaaaat 2400

aataaaaaat attaataaac aaaaaaaaaa ttatcttaag agaggagaat gttataatat 2460

2520

aagattttaa tttaatgatt gattaagtta aaaatgtgta tgtaataaat tttattttat 2580

ttattgacta aattataaag tttacataat tatttaataa ttatgtaatt gttacttgaa 2640

aattgatcta ttttaaaatc tagttataac ttcaaaaaag actgaaaatt aagaaaaaag 2700

aaatataaat ataaaaatat gtcatataga ttttttttat tttactttaa taaaatgatt 2760

tgtttttaca atacttttatt aatataaagt ttattgctaa aatactttat ttattagaaa 2820

aagatacta attaattatt aaaattaatg tattcataat gcatattttc atataaaatt 2880

taatttattt gccgattata taattataat tactgattta attccaatgt tgttcaaaat 2940

3000

3060

gtttaagcca ttagtaaaaa aacttagtag agttttacat tatgaagagg gagaaacaga 3120

tttaataata ttttttattg aattaataaa aaatattaaa ttaagtagct tttcagaaaa 3180

3240

3300

3360

tattttgaaa gaattatctg gtattcaaag aaaagtttatt ttttataaat atttaaaagg 3420

atattctgat agagaaatat cagtgaaatt aaaaatatct agacaagctg ttaataaggc 3480

taaaaataga gcatttaaaa aaataaaaaa agactatgaa aattatttta acttgtaatt 3540

3600

atcaataact taatctaaga atatcttaat ttttatattt tatatagaac aaagtttaca 3660

tatttatttc agacaacgtc tttattcaat cgaagagcaa attaatcaac tgagtgtctt 3720

3780

3840

3900

agatttcgta ctcaagaaga tgaatatgtt gcaatattgg atgctttaga agaatatcat 3960

4020

acagatattt atatagatac atataaaaaa tctggtagaa ataaagcctt aaaaaaattt 4080

aaggaatatc tagttacaga agtattagag ctaaagaata ataatttaac tccagttgag 4140

aaaaatttac attttgtttg gattggaggt caaataaatg acactgctat taattatata 4200

aatcaatgga aagatgtaaa tagtgattat aatgttaatg ttttttatga tagtaatgca 4260

tttttgataa acacattgaa aaaaactgta gtagaatcag caataaatga tacacttgaa 4320

aaaacttaaa tgaccctaga tttgactata ataaattctt cagaaaacgt 4380

atggaaataa tttatgataa acagaaaaat ttcataaact actataaagc tcaaagagaa 4440

gaaaatcctg aacttataat tgatgatatt gtaaagacat atctttcaaa tgagtattca 4500

4560

agtggaaatg atgttagaaa ctttgaagaa tttaaaaatg gagagtcatt caacttatat 4620

gaacaagagt tggtagaaag gtggaattta gctgctgctt ctgacatatt aagaatatct 4680

gcattaaaag aaattggtgg tatgtattta gatgttgata tgttaccagg aatacaacca 4740

gacttatttg agtctataga gaaacctagt tcagtaacag tggatttttg ggaaatgaca 4800

4860

gacatgttag acgaagaagt tcaaagtagt tttgaatctg ttctagcttc taagtcagat 4920

aaatcagaaa tattctcatc acttggtgat atggaggcat caccactaga agttaaaatt 4980

gcatttaata gtaagggtat tataaatcaa gggctaattt ctgtgaaaga ctcatattgt 5040

5100

ccagctatta gcgaggataa tgattttaat actacaacga atacctttat tgatagtata 5160

atggctgaag ctaatgcaga taatggtaga tttatgatgg aactaggaaa gtatttaaga 5220

gttggtttct tcccagatgt taaaactact attaacttaa gtggccctga agcatatgcg 5280

gcagcttatc aagatttatt aatgtttaaa gaaggcagta tgaatatcca tttgatagaa 5340

gctgatttaa gaaactttga aatctctaaa actaatattt ctcaatcaac tgaacaagaa 5400

atggctagct tatggtcatt tgacgatgca agagctaaag ctcaatttga agaatataaa 5460

aggaattatt ttgaaggttc tcttggtgaa gatgataatc ttgatttttc tcaaaatata 5520

gtagttgaca aggagtatct tttagaaaaa atatcttcat tagcaagaag ttcagagaga 5580

ggatatatac actatattgt tcagttacaa ggagataaaa ttagttatga agcagcatgt 5640

aacttatttg caaagactcc ttatgatagt gtactgtttc agaaaaatat agaagattca 5700

gaaattgcat attattataa tcctggagat ggtgaaatac aagaaataga caagtataaa 5760

attccaagta taatttctga tagacctaag attaaattaa catttattgg tcatggtaaa 5820

gatgaattta atactgatat atttgcaggt tttgatgtag attcattatc cacagaaata 5880

gaagcagcaa tagatttagc taaagaggat atttctccta agtcaataga aataaattta 5940

ttaggatgta atatgtttag ctactctatc aacgtagagg agacttatcc tggaaaatta 6000

ttacttaaag ttaaagataa aatatcagaa ttaatgccat ctataagtca agactctatt 6060

atagtaagtg caaatcaata tgaagttaga ataaatagtg aaggaagaag agaattattg 6120

6180

gaatatatat catttaatcc taaagaaaat aaaattacag taaaatctaa aaatttacct 6240

gagctatcta cattattaca agaaattaga aataattcta attcaagtga tattgaacta 6300

6360

attgttgagg aaaggattga agaagctaag aatttaactt ctgactctat taattatata 6420

6480

6540

6600

acaatattct ctgaatatgc taatcatata actgaagaga tttctaagat aaaaggtact 6660

atatttgata ctgtaaatgg taagttagta aaaaaagtaa atttagatac tacacacgaa 6720

6780

gaatctctta gtaatttaag tgtagcaatg aaagtccaag tttacgctca attatttagt 6840

actggtttaa atactattac agatgcagcc aaagttgttg aattagtatc aactgcatta 6900

6960

atagatggtg taagtttagg tgcagcaatc aaagagctaa gtgaaacgag tgacccatta 7020

ttaagacaag aaatagaagc taagataggt ataatggcag taaatttaac aacagctaca 7080

actgcaatca ttacttcatc tttggggata gctagtggat ttagtatact tttagttcct 7140

ttagcaggaa tttcagcagg tataccaagc ttagtaaaca atgaacttgt acttcgagat 7200

aaggcaacaa aggttgtaga ttattttaaa catgtttcat tagttgaaac tgaaggagta 7260

tttactttat tagatgataa aataatgatg ccacaagatg atttagtgat atcagaaata 7320

gattttaata ataattcaat agttttaggt aaatgtgaaa tctggagaat ggaaggtggt 7380

tcaggtcata ctgtaactga tgatatagat cacttctttt cagcaccatc aataacatat 7440

agagagccac acttatctat atatgacgta ttggaagtac aaaaagaaga acttgatttg 7500

tcaaaagatt taatggtatt acctaatgct ccaaatagag tatttgcttg ggaaacagga 7560

tggacaccag gtttaagaag cttagaaaat gatggcacaa aactgttaga ccgtataaga 7620

7680

acaacattaa aaccaagata tgaagatact aatataagaa taaatttaga tagtaatact 7740

agaagtttta tagttccaat aataactaca gaatatataa gagaaaaatt atcatattct 7800

ttctatggtt caggaggaac ttatgcattg tctctttctc aatataatat gggtataaat 7860

atagaattaa gtgaaagtga tgtttggatt atagatgttg ataatgttgt gagagatgta 7920

actatagaat ctgataaaat taaaaaaggt gatttaatag aaggtatttt atctacacta 7980

agtattgaag agaataaaat tatcttaaat agccatgaga ttaatttttc tggtgaggta 8040

aatggaagta atggatttgt ttctttaaca ttttcaattt tagaaggaat aaatgcaatt 8100

atagaagttg atttattatc taaatcatat aaattactta ttctggcga attaaaaata 8160

ttgatgttaa attcaaatca tattcaacag aaaatagatt atataggatt caatagcgaa 8220

ttacagaaaa atataccata tagctttgta gatagtgaag gaaaagagaa tggttttatt 8280

aatggttcaa caaaagaagg tttatttgta tctgaattac ctgatgtagt tcttataagt 8340

8400

8460

ataaaaatct ctctttcttt gactctacaa gatgaaaaaa ctataaagtt aaatagtgtg 8520

catttagatg aaagtggagt agctgagatt ttgaagttca tgaatagaaa aggtaataca 8580

aatacttcag attctttaat gagcttttta gaaagtatga atataaaaag tattttcgtt 8640

aatttcttac aatctaatat taagtttata ttagatgcta attttataat aagtggtact 8700

acttctattg gccaatttga gtttatttgt gatgaaaatg ataatataca accatatttc 8760

attaagttta atacactaga aactaattat actttatatg taggaaatag acaaaatatg 8820

atagtggaac caaattatga tttagatgat tctggagata tatcttcaac tgttatcaat 8880

ttctctcaaa agtatcttta tggaatagac agttgtgtta ataaagttgt aatttcacca 8940

aatattata cagatgaaat aaatataacg cctgtatatg aaacaaataa tacttatcca 9000

9060

ctatctatac gatatgtatg gagtaatgat ggtaatgatt ttattcttat gtcaactagt 9120

gaagaaaata aggtgtcaca agttaaaata agattcgtta atgtttttaa agataagact 9180

ttggcaaata agctatcttt taactttagt gataaacaag atgtacctgt aagtgaaata 9240

atcttatcat ttacaccttc atattatgag gatggattga ttggctatga tttgggtcta 9300

gtttctttat ataatgagaa attttatatt aataactttg gaatgatggt atctggatta 9360

atatatatta atgattcatt atattatttt aaaccaccag taaataattt gataactgga 9420

tttgtgactg taggcgatga taaatactac tttaatccaa ttaatggtgg agctgcttca 9480

attggagaga caataattga tgacaaaaat tattatttca accaaagtgg agtgttacaa 9540

acaggtgtat ttagtacaga agatggattt aaatattttg ccccagctaa tacacttgat 9600

gaaaacctag aaggagaagc aattgatttt actggaaaat taattattga cgaaaatatt 9660

tattattttg atgataatta tagaggagct gtagaatgga aagaattaga tggtgaaatg 9720

cactatttta gccgaaac aggtaaagct tttaaaggtc taaatcaaat aggtgattat 9780

aaatactatt tcaattctga tggagttatg caaaaaggat ttgttagtat aaatgataat 9840

aaacactatt ttgatgattc tggtgttatg aaagtaggtt acactgaaat agatggcaag 9900

catttctact ttgctgaaaa cggagaaatg caaataggag tatttaatac agaagatgga 9960

tttaaatatt ttgctcatca taatgaagat ttaggaaatg aagaaggtga agaaatctca 10020

10080

10140

gaagcatata taggtttgtc attaataaat gatggtcaat attattttaa tgatgatgga 10200

attatgcaag ttggatttgt cactataaat gataaagtct tctacttctc tgactctgga 10260

attatagaat ctggagtaca aaacatagat gacaattatt tctatataga tgataatggt 10320

atagttcaaa ttggtgtatt tgatacttca gatggatata aatattttgc acctgctaat 10380

actgtaaatg ataatattta cggacaagca gttgaatata gtggtttagt tagagttggg 10440

gaagatgtat attattttgg agaaacatat acaattgaga ctggatggat atatgatatg 10500

gaaaatgaaa gtgataaata ttatttcaat ccagaaacta aaaaagcatg caaaggtatt 10560

aatttaattg atgatataaa atattatttt gatgagaagg gcataatgag aacgggtctt 10620

atatcatttg aaaataataa ttattacttt aatgagaatg gtgaaatgca atttggttat 10680

ataaatatag aagataagat gttctatttt ggtgaagatg gtgtcatgca gattggagta 10740

10800

gagggagaat caataaacta tactggttgg ttagatttag atgaaaagag atattatttt 10860

acagatgaat atattgcagc aactggttca gttattattg atggtgagga gtattatttt 10920

10980

11040

11100

11160

11220

tacattatta ggatgtttaa gtgcaataaa aagtcgtaaa tttaattcta gttttggaat 11280

agatggagga atcagaaaag tagcaatgat agcatgtata ttttttttat cagtagttga 11340

cattcttaca aagtttaact ttttatttat gttaccacaa gattgtatca attttttaag 11400

actaaaacat cttggaatat ctgaattttt ctctatttta tttattttat atgaaagtgt 11460

aagtatatta aaaaatatgt gcttatgtgg attaccagta cctaagagat taaaggaaaa 11520

11580

11640

11700

acaagtatta aatacatata atttcgaagc aagtgttcat tactatatag atgacaaggt 11760

agtatatcaa acattggttc acaaagatgg tgcatggtca gttggtaaaa tctattaagc 11820

tacattagtt acagatatca caaactataa tagttaaaca tagaaatatg tgtaaattgt 11880

gatggaaatt attcaaaaac acaaaaatac gtgatgaagg acaaaatgat atagaaaata 11940

12000

12060

12120

tgatttaaat atgaaaactt aaattataaa aaatcaatat taatttattt ttaaaaaata 12180

gaaaggagtg tataagattt attttcaaag tttaaaaaca agaaaatcaa tttaaatttc 12240

agaaggaata aatgtggtta tagaagtgga tttattatca aaaataataa tactaggagg 12300

tttttatgtc tttaatatct aaagaagagt taataaaact cgcatatagc attagaccaa 12360

gagaaaatga gtataaaact atactaacta atttagacga atataataag ttaactacaa 12420

acaataatga aaataaatat ttgcaattaa aaaaactaaa tgaatcaatt gatgttttta 12480

tgaataaata taaaacttca agcagaaata gagcactctc taatctaaaa aaagatatat 12540

taaaagaagt aattcttatt aaaaattcca atacaagccc tgtagaaaaa aatttacatt 12600

ttgtatggat aggtggagaa gtcagtgata ttgctcttga atacataaaa caatgggctg 12660

tgaagcattc ttagtaaata 12720

12780

agattcaaaa tcctcaattt gataatatga aattttacaa aaaaaggatg gaatttatat 12840

12900

ctacaataga tgatattata aagtctcatc tagtatctga atataataga gatgaaactg 12960

tattagaatc atatagaaca aattctttga gaaaaataaa tagtaatcat gggatagata 13020

13080

taaatcgtgg aaatttagct gcagcatctg acatagtaag attattagcc ctaaaaaatt 13140

ttggcggagt atatttagat gttgatatgc ttccaggtat tcactctgat ttatttaaaa 13200

caatatctag acctagctct attggactag accgttggga aatgataaaa ttagaggcta 13260

ttatgaagta taaaaaatat ataaataatt atacatcaga aaactttgat aaacttgatc 13320

13380

tttctaaatt agaaaattta aatgtatctg atcttgaaat taaaatagct ttcgctttag 13440

gcagtgttat aaatcaagcc ttgatatcaa aacaaggttc atatcttact aacctagtaa 13500

tagaacaagt aaaaaataga tatcaatttt taaaccaaca ccttaaccca gccatagagt 13560

13620

13680

13740

13800

aatttaaatt cccagaaaat aatctatctc aattgacaga acaagaaata aatagtctat 13860

ggagctttga tcaagcaagt gcaaaatatc aatttgagaa atatgtaaga gattatactg 13920

gtggatctct ttctgaagac aatggggtag actttaataa aaatactgcc ctcgacaaaa 13980

actatttatt aaataataaa attccatcaa acaatgtaga agaagctgga agtaaaaatt 14040

14100

tattttctaa aaatcctaaa aatagtatta ttatacaacg aaatatgaat gaaagtgcaa 14160

14220

ctgaaagatt aaaaaataag gaaaaagtaa aagtaacctt tattggacat ggtaaagatg 14280

aattcaacac aagcgaattt gctagattaa gtgtagattc actttccaat gagataagtt 14340

catttttaga taccataaaa ttagatatat cacctaaaaa tgtagaagta aacttacttg 14400

gatgtaatat gtttagttat gattttaatg ttgaagaaac ttatcctggg aagttgctat 14460

taagtattat ggacaaaatt acttccactt tacctgatgt aaataaaaat tctattacta 14520

taggagcaaa tcaatatgaa gtaagaatta atagtgagg aagaaaagaa cttctggctc 14580

actcaggtaa atggataaat aaagaagaag ctattatgag cgatttatct agtaaagaat 14640

acattttttt tgattctata gataataagc taaaagcaaa gtccaagaat attccaggat 14700

14760

caaaatttat tttaaataat cttaagctta atattgaatc ttctattgggg gattacattt 14820

14880

atgagttcaa tctacttgaa aatgtatctg atgaattata tgaattaaaa aaattaaata 14940

atctagatga gaagtattta atatcttttg aagatatctc aaaaaataat tcaacttact 15000

15060

ttttttcaaa atatagcgaa catattacaa aagaaataag tactataaag aatagtataa 15120

15180

atacattaaa cgcagcattc tttattcaat cattaataga ttatagtagc aataaagatg 15240

tactgaatga tttaagtacc tcagttaagg ttcaactta tgctcaacta tttagtacag 15300

tctatccaat tagtaaattt aatatcaaat gcagtaaatg 15360

atactataaa tgtactacct acaataacag aggggatacc tattgtatct actatattag 15420

acggaataaa cttaggtgca gcaattaagg aattactaga cgaacatgac ccattactaa 15480

15540

caactgtagc ttcaattgtt ggaataggtg ctgaagttac tattttctta ttacctatag 15600

15660

caacttcagt ggtaaactat tttaatcatt tgtctgaatc taaaaaatat ggccctctta 15720

15780

ttaataataa ttcgataaaa ctaggaacat gtaatatatt agcaatggag gggggatcag 15840

gacacacagt gactggtaat atagatcact ttttctcatc tccatctata agttctcata 15900

ttccttcatt atcaatttat tctgcaatag gtatagaaac agaaaatcta gatttttcaa 15960

aaaaaataat gatgttacct aatgctcctt caagagtgtt ttggtgggaa actggagcag 16020

ttccaggttt aagatcattg gaaaatgacg gaactagatt acttgattca ataagagatt 16080

cgattatgca ataactacat 16140

taaaaccagt ttatgaagac actaatatta aaattaaact agataaagat actagaaact 16200

tcataatgcc aactataact actaacgaaa ttagaaacaa attatcttat tcatttgatg 16260

gagcaggagg aacttactct ttattattat cttcatatcc aatatcaacg aatataaatt 16320

16380

16440

ataaaaataa acttattata ggcaatcaaa caatagattt ttcaggcgat

16560

16620

ccaatttatc taatactatt gagaaaatca atactttagg cctagatagt aaaaatatag 16680

cgtacaatta cactgatgaa tctaataata aatattttgg agctatatct aaaacaagtc 16740

aaaaaagcat aatacattat aaaaaagaca gtaaaaatat attagaattt tataatgaca 16800

16860

atgatattaa tactataaca ggaaaatact atgttgataa taatactgat aaaagtatag 16920

16980

aatccgtata ctcatcttac cttgattttg tgaaaaattc agatggacac cataatactt 17040

ctaattttat gaatttattt ttggacaata taagtttctg gaaattgttt gggtttgaaa 17100

atataaattt tgtaatcgat aaatacttta cccttgttgg taaaactaat cttggatatg 17160

tagatttat ttgtgacaat aataaaaata tagatatata ttttggtgaa tggaaaacat 17220

17280

ataatcctga tacgggtgaa gatatatcta cttcactaga ttttttcctat gaacctctct 17340

17400

taaatattaa taccaattat tattcaaatg agtactaccc tgagattata gttcttaacc 17460

caaatacatt ccacaaaaaa gtaaatataa atttagatag ttcttctttt gagtataaat 17520

ggtctacaga aggaagtgac tttattttag ttagatactt agaagaaagt aataaaaaaa 17580

tattacaaaa aataagaatc aaaggtatct tatctaatac tcaatcattt aataaaatga 17640

gtatagattt taaagatatt aaaaaactat cattaggata tataatgagt aattttaaat 17700

catttaattc tgaaaatgaa ttagatagag atcatttagg atttaaaata atagataata 17760

aaacttatta ctatgatgaa gatagtaaat tagttaaagg attaatcaat ataaataatt 17820

cattattcta ttttgatcct atagaattta acttagtaac tggatggcaa actatcaatg 17880

gtaaaaaata ttatttttgat ataaatactg gagcagcttt aactagttat aaaattatta 17940

18000

ctgatggatt tgaatatttt gcacctgcca atactcaaaa taataacata gaaggtcagg 18060

ctatagttta tcaaagtaaa ttcttaactt tgaatggcaa aaaatattat tttgataata 18120

actcaaaagc agtcactgga tggagaatta ttaacaatga gaaatattac tttaatccta 18180

18240

ctgacactgc tatcatctca aaaggttggc agactgttaa tggtagtaga tactactttg 18300

atactgatac cgctattgcc tttaatggtt ataaaactat tgatggtaaa cacttttatt 18360

ttgatagtga ttgtgtagtg aaaataggtg tgtttagtac ctctaatgga tttgaatatt 18420

ttgcacctgc taatacttat aataataaca tagaaggtca ggctatagtt tatcaaagta 18480

aattcttaac tttgaatggt aaaaaatatt actttgataa taactcaaaa gcagttaccg 18540

gattgcaaac tattgatagt aaaaaatatt actttaatac taacactgct gaagcagcta 18600

ctggatggca aactattgat ggtaaaaaat attactttaa tactaacact gctgaagcag 18660

ctactggatg gcaaactatt gatggtaaaa aatattactt taatactaac actgctatag 18720

cttcaactgg ttatacaatt attaatggta aacattttta ttttaatact gatggtatta 18780

tgcagatagg agtgtttaaa ggacctaatg gatttgaata ttttgcacct gctaatacgg 18840

atgctaacaa catagaaggt caagctatac tttaccaaaa tgaattctta actttgaatg 18900

gtaaaaaata ttactttggt agtgactcaa aagcagttac tggatggaga attattaaca 18960

ataagaaata ttactttaat cctaataatg ctattgctgc aattcatcta tgcactataa 19020

19080

19140

aaggacctaa tggatttgag tattttgcac ctgctaatac tcacaataat aacatagaag 19200

gtcaggctat agtttaccag aacaaattct taactttgaa tggcaaaaaa tattattttg 19260

ataatgactc aaaagcagtt actggatggc aaaccattga tggtaaaaaa tattacttta 19320

atcttaacac tgctgaagca gctactggat ggcaaactat tgatggtaaa aaatattact 19380

ttaatcttaa cactgctgaa gcagctactg gatggcaaac tattgatggt aaaaaatatt 19440

actttaatac taacactttc atagcctcaa ctggttatac aagtattaat ggtaaacatt 19500

tttattttaa tactgatggt attatgcaga taggagtgtt taaaggacct aatggatttg 19560

aatactttgc acctgctaat acggatgcta acaacataga aggtcaagct atactttacc 19620

aaaataaatt cttaactttg aatggtaaaa aatattactt tggtagtgac tcaaaagcag 19680

ttaccggact gcgaactatt gatggtaaaa aatattactt taatactaac actgctgttg 19740

cagttactgg atggcaaact attaatggta aaaaatacta ctttaatact aacacttcta 19800

tagcttcaac tggttataca attattagtg gtaaacattt ttattttaat actgatggta 19860

ttatgcagat aggagtgttt aaaggacctg atggatttga atactttgca cctgctaata 19920

cagatgctaa caatatagaa ggtcaagcta tacgttatca aaatagattc ctatatttac 19980

atgacaatat atattatttt ggtaataatt caaaagcggc tactggttgg gtaactattg 20040

atggtaatag atattacttc gagcctaata cagctatgggg tgcgaatggt tataaaacta 20100

20160

ctaatggatt tgaatacttt gcacctgcta atacggatgc taacaatata gaaggtcaag 20220

20280

20340

atactgctat ggctgcagct ggtggacttt tcgagattga tggtgttata tatttctttg 20400

20460

attcctgtgc tactaagaaa ttatttttat ataataaata ttgagattta attaaaagtc 20520

atgtgttatt gtaatacatg acttttagtt aaaatttttc tatcatttaa taatctatta 20580

20640

ttgataaaaa atagataata tgctaaaagc aaaaactaat ttagagcctt gtaactgttt 20700

20760

tacaaaacaa tattaattaa ttttctctac agctatccct ggtatagtta tatttccacc 20820

catagttgat tcataagtta tagttccagc acttatacct cttatagtta tgtaatcatc 20880

20940

atttccagac acagctaatc ttatttgcac ctcatcacca tcttcaataa cttgaataac 21000

cttaccttca aatttacctt ttgtactata atcatcaggt gttctagcta attggtcata 21060

agtaatacca gtatcatatc ctttcttctc ctcttcttct tttttgcgtt gttcttcagc 21120

ctttttagct tcttcagctt ttttagcttc ttcagcttta cgttgatttt cagcttcaat 21180

agctttcttt tcgtcgtctt tcattttgaa ccatggttca gcatcagaca atttgctatt 21240

taaagtttct atttctgttt tttgagaatc tataactgat gtttggttag aaatgacctc 21300

ctcatggtct tcagaacaag ctggtgagga tatattgcca aaaaacacgc ctaaaataaa 21360

tgccagtaga gcaataccct ttgtgctctt aaagaattta attattttct tagagcttcc 21420

ttttccttca ttactaaatt cgttaccctc atttttttta gaaaacataa tacaatctcc 21480

cttttattag atatatttta ttttaaaagt taaaaactta aaataactag ttgactaaaa 21540

attatatatt catattttcc taaaatatat ttcccctaag cataatttta caaaataaag 21600

21660

tcttgaaggt gaattttata tattaaatta aacataaagt

tattatgatg taattaagtg actcagtgat ttagaggtgg taaaatatat atatatgaaa 21780

gagcataaat aaattgatat aataaaaaat taaatattaa atattaacta taataaaaaa 21840

atatctggta ataggtataa tataaaaaga atataccaga aagaaggtga agtatgggag 21900

aactacaaaa aattccaggg gtagggaaag caacagaaaa atctttaatc atgttaggat 21960

22020

22080

ttgcatcaac tgaaaatcca gaaccagaaa aattaaagtg gtggtattgg aaagattaaa 22140

22200

tactcaactc ttttttagtc gtaaatttta tgtaaatcta tttgtatggc taaatatacc 22260

catcaataaa tgtataaata taccaatcaa caaatgacta aacatactac ctaacaaagg 22320

22380

ccattttcta cattgctcaa tatttaccat agggtcaaaa ccttggtctt ttcccttatt 22440

taaaagcata tcacaaggga aagtatcaca ttcaccacaa tgattaagtt ccttactttc 22500

acagcaagtt ttaaccttac attctccacc ccaaaatggt ttttccatag ttgggcaacc 22560

agtgcaattt acttgttctt tttttgtaca actgtcacaa cagacaccac atcttgattc 22620

22680

22740

tggtaaattt ataaaaacta ttccaaaaat ctttttgaat atttcaaaac acaataaatt 22800

acttcaaatc cctttgaata tattttacag cattatagat tgctttaaat ctctttgaat 22860

attctacaag actatagatt agtttaaatc tctttgagta ttctacaaga ctatagatta 22920

gtttaaatcc ctttgaatat ttcaaaacac catagattac tttaaattcc tttgaatatt 22980

23040

taaatggagt tttatatcaa atttgccttc catcgaataa ccaaacttaa tttaattaca 23100

cattccaaga gtcaaatatt cattcaatat atttgataat tctatgttat agctataatt 23160

23220

ttaattaagt ttcattatat aatataaaaa ttgtttttgc attaagtttt aatataatac 23280

23340

23400

23460

ccattaagaa ataacatcat tctttctaaa atttctattg gcaatttcag aaaatactat 23520

23580

ctttataacc cccatacgac tacctaacat agaataaggg aaaaatatac caacagcagg 23640

ttttgctact attaatccca taccaaatag agaaaggcaa agactaatac caataggagt 23700

tgcaaaactt ctaatcttta tagacatgta taattgtata gaagctattg aaatagaaat 23760

aatccaacct ttagcaatcc aaccagtcaa ttctttaggt acactaccag aaaaaccaaa 23820

catatttcct gcaactatat aaaagataac aaagaaaact tgtgtaatag ctgtaagtat 23880

tgaaactact gtaagtttag ataaaaagat attttttaaa ttaactggca gtgtcattac 23940

attattccaa ttatgattca tatgttcaag cctacaaata tatgcacaaa agattgcgat 24000

taagatagga aagaaaaatt ccccataaaa aagactaact tgagtccata agctgtacca 24060

ttcttttttg agtatgcctt gatttagata aaaattacca gaaccaatca acacacttat 24120

aagtggcaaa gctagtaata cataccatat aaaagaattt tttaacttta gaatttctcc 24180

24240

cttccaatat aataaattag cattccaatt aagaaaacta aaatcgtaat agaaaaattc 24300

atatcaattc tatagacaga tgaacctaaa acattatcat aagcataact taaaggtgat 24360

aactctaggt aataagacca tataaacaat ctacgaatac cttgataaaa caaacctgat 24420

gtcaaaccta taaaactacc aatcatgcca aatgtaattg caatcatttg atttggaatt 24480

acagttgcaa tccataggtg tagtgcaatg atagcaatac ttacaagaat tgttcctaat 24540

gtgtatttta aaagtaaaga tacagaaatt gactcaataa cccctctaaa atgtccaaac 24600

aacacaatag ataacacttg catcaataca ggtatagata ccaaaatagc agaacataaa 24660

24720

tctcctttat gttctatatc gcttatacgt gatgtaatta ttgatattaa gataggaaag 24780

aatagaccat ttaaacttgc aaaactcata agcatatagg aatattcaaa tccacctaac 24840

atatctggat tacgtgtaat agccctattt gaatttacga tacaccacat tatttcaaca 24900

gctacaaata aaaaggtcat cagaataatc ttctttcttt taagtttata aaattctaga 24960

ccaaggtatt tcattataaa gtcaccgcct taccagtaat tctaagaata tatcttccaa 25020

25080

tattttagcg acatctgagt cttttaaatt ttcaatagtc aagtacccat cttgtataag 25140

25200

agcaatctga ctttgacctc tattatgaag ttcttttatg ctatcttgaa aaaccagttc 25260

25320

agagattaga acagtcatcc cgtatttttc tggtagagat ttttattaatt ctctaatttc 25380

ctcaatccct gctgggtcga gtccatttgt aggttcatca agtattaata atttgggaaa 25440

cttcattatt gccatagcaa tgccaagacg ttgcttcata cctaaagaat attgactaac 25500

ttttttattt ttttgatttt ctaaccttac aatttttaat gcttcattta cattttttt 25560

aggtaaatct aagagtcttt gcattatggt catgttttca agccctgtaa gatgaccata 25620

gtatgatgga gattctatca aagaacctat atcttttaaa attgatattc tatttttttc 25680

tttaactct ttacctaaaa tattaatatt tccttgtgtg ggtttagcaa gtccaagaag 25740

cattttaaga gtggtagatt ttccagctcc attaggaccc aaaaaaccat atacagctcc 25800

25860

tctttgtgtt ctaattatca tttccatatg tttcatcccc ttttttaatc tgtgcttatt 25920

gattctttta acttatatca gtataataac ttggttacat ttcaattagc tgaaatttac 25980

cttacaataa ccttaaaagt ctatttaggc aaagttgtga aaatgggtat atggtatac 26039

<210> 28

<211> 193

<212> PROTEIN

<213> Clostridium difficile

<400> 28

Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr Ile Lys Gln

1 5 10 15

Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp Tyr Asp Ser

20 25 30

Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val Glu Ser Ser

35 40 45

Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln Asn Pro Gln

50 55 60

Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe Ile Tyr Asp

65 70 75 80

Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile Asn Lys Pro

85 90 95

Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu Val Ser Glu

100 105 110

Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr Asn Ser Leu

115 120 125

Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala Asn Ser Leu

130 135 140

Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu Leu Leu Asn

145 150 155 160

Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu Leu Ala Leu

165 170 175

Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu Pro Gly Ile

180 185 190

His

<210> 29

<211> 542

<212> PROTEIN

<213> Clostridium difficile

<400> 29

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu

530 535 540

<210> 30

<211> 193

<212> PROTEIN

<213> Clostridium difficile

<400> 30

Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn Tyr Ile Asn

1 5 10 15

Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val Phe Tyr Asp

20 25 30

Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val Val Glu Ser

35 40 45

Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu Asn Asp Pro

50 55 60

Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu Ile Ile Tyr

65 70 75 80

Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln Arg Glu Glu

85 90 95

Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr Leu Ser Asn

100 105 110

Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile Glu Glu Ser

115 120 125

Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg Asn Phe Glu

130 135 140

Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln Glu Leu Val

145 150 155 160

Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg Ile Ser Ala

165 170 175

Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met Leu Pro Gly

180 185 190

ile

<210> 31

<211> 543

<212> PROTEIN

<213> Clostridium difficile

<400> 31

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 32

<211> 267

<212> PROTEIN

<213> Clostridium difficile

<400> 32

Ser Glu Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys

1 5 10 15

Asn Tyr Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala

20 25 30

Gly Ser Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp

35 40 45

Ile Ser Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn

50 55 60

Ser Ile Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe

65 70 75 80

Leu Ser Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile

85 90 95

Pro Glu Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly

100 105 110

His Gly Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val

115 120 125

Asp Ser Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu

130 135 140

Asp Ile Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met

145 150 155 160

Phe Ser Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu

165 170 175

Leu Ser Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys

180 185 190

Asn Ser Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser

195 200 205

Glu Gly Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys

210 215 220

Glu Glu Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe

225 230 235 240

Asp Ser Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly

245 250 255

Leu Ala Ser Ile Ser Glu Asp Ile Lys Thr Leu

260 265

<210> 33

<211> 224

<212> PROTEIN

<213> Clostridium difficile

<400> 33

Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys

1 5 10 15

Glu Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg

20 25 30

Gly Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr

35 40 45

Glu Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu

50 55 60

Phe Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro

65 70 75 80

Gly Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile

85 90 95

Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys

100 105 110

Asp Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu

115 120 125

Ser Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser

130 135 140

Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

145 150 155 160

Ser Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val

165 170 175

Lys Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile

180 185 190

Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

195 200 205

Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser

210 215 220

<210> 34

<211> 2710

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: C. difficile mutant

TcdA

<220>

<221> OTHER_INDICATOR

<222> (101)..(101)

<223> Xaa is any amino acid

<220>

<221> OTHER_INDICATOR

<222> (269)..(269)

<223> Xaa is any amino acid

<220>

<221> OTHER_INDICATOR

<222> (272)..(272)

<223> Xaa is any amino acid

<220>

<221> OTHER_INDICATOR

<222> (285)..(285)

<223> Xaa is any amino acid

<220>

<221> OTHER_INDICATOR

<222> (287)..(287)

<223> Xaa is any amino acid

<220>

<221> OTHER_INDICATOR

<222> (460)..(460)

<223> Xaa is any amino acid

<220>

<221> OTHER_INDICATOR

<222> (462)..(462)

<223> Xaa is any amino acid

<220>

<221> OTHER_INDICATOR

<222> (541)..(541)

<223> Xaa is any amino acid

<220>

<221> OTHER_INDICATOR

<222> (542)..(542)

<223> Xaa is any amino acid

<220>

<221> OTHER_INDICATOR

<222> (543)..(543)

<223> Xaa is any amino acid

<220>

<221> OTHER_INDICATOR

<222> (589)..(589)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (655)..(655)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (700)..(700)

<223> Xaa is any amino acid.

<400> 34

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Xaa Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Xaa Ile Val Xaa

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Xaa Val Xaa Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Xaa Ala Xaa Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Xaa Xaa Xaa Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Xaa Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly Xaa Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Xaa Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 35

<211> 2366

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: C. difficile mutant

TcdB

<220>

<221> OTHER_INDICATOR

<222> (102)..(102)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (270)..(270)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (273)..(273)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (286)..(286)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (288)..(288)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (384)..(384)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (520)..(520)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (543)..(543)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (544)..(544)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (587)..(587)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (600)..(600)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (653)..(653)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (698)..(698)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (751)..(751)

<223> Xaa is any amino acid.

<400> 35

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Xaa Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Xaa Ile Leu

260 265 270

Xaa Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Xaa Val Xaa

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Xaa

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Ala Val Ala Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Xaa Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Xaa Xaa

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Xaa Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Xaa Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly Xaa Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Xaa Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Xaa Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 36

<211> 146

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: variable

light chain region A3-25 mAb IgE

<400> 36

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Gly

1 5 10 15

Ser Ser Ser Asp Val Val Met Thr His Thr Pro Leu Ser Leu Pro Val

20 25 30

Ser Leu Gly Asp Gln Ala Ser Met Ser Cys Arg Ser Ser Gln Ser Leu

35 40 45

Ile His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro

50 55 60

Gly Gln Ser Pro Lys Leu Leu Ile Ser Lys Val Ser Asn Arg Phe Ser

65 70 75 80

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr

85 90 95

Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys

100 105 110

Ser Gln Thr Thr Tyr Phe Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu

115 120 125

Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro

130 135 140

Ser Ser

145

<210> 37

<211> 189

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: variable

heavy chain region A3-25 mAb IgE

<400> 37

Met Tyr Leu Gly Leu Asn Cys Val Phe Ile Val Phe Leu Leu Lys Gly

1 5 10 15

Val Gln Ser Glu Val Asn Leu Glu Glu Ser Gly Gly Gly Leu Val Gln

20 25 30

Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe

35 40 45

Thr Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu

50 55 60

Glu Trp Ile Ala Glu Ile Arg Leu Lys Ser His Asn Tyr Ala Thr His

65 70 75 80

Phe Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser

85 90 95

Lys Ser Ala Val Ser Leu Gln Met Thr Asn Leu Thr Pro Glu Asp Thr

100 105 110

Gly Ile Phe Tyr Cys Thr Trp Asp Tyr Tyr Gly Asn Pro Ala Phe Val

115 120 125

Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Ile Arg

130 135 140

Asn Pro Gln Leu Tyr Pro Leu Lys Pro Cys Lys Gly Thr Ala Ser Met

145 150 155 160

Thr Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Gly Pro Val Thr Val

165 170 175

Thr Trp Tyr Ser Asp Ser Leu Asn Met Ser Thr Val Asn

180 185

<210> 38

<211> 16

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: CDR1 variable

light chain region A3-25 mAb

<400> 38

Arg Ser Ser Gln Ser Leu Ile His Ser Asn Gly Asn Thr Tyr Leu His

1 5 10 15

<210> 39

<211> 7

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: CDR2 variable

light chain region A3-25 mAb

<400> 39

Lys Val Ser Asn Arg Phe Ser

fifteen

<210> 40

<211> 9

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: CDR3 variable

light chain region A3-25 mAb

<400> 40

Ser Gln Thr Thr Tyr Phe Pro Tyr Thr

fifteen

<210> 41

<211> 10

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: CDR1 variable

heavy chain area A3-25 mAb

<400> 41

Gly Phe Thr Phe Thr Asn Tyr Trp Met Asn

1 5 10

<210> 42

<211> 19

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: CDR2 variable

heavy chain area A3-25 mAb

<400> 42

Glu Ile Arg Leu Lys Ser His Asn Tyr Ala Thr His Phe Ala Glu Ser

1 5 10 15

Val Lys Gly

<210> 43

<211> 10

<212> PROTEIN

<213> Artificial

<220>

<223> Synthetic amino acid sequence: CDR3 variable

heavy chain area A3-25 mAb

<400> 43

Asp Tyr Tyr Gly Asn Pro Ala Phe Val Tyr

1 5 10

<210> 44

<211> 8142

<212> DNA

<213> Artificial

<220>

<223> Synthetic nucleotide sequence: TcdA gene (mutations

D285A D287A)

<400> 44

catatgtctt taatatctaa agaagagtta ataaaactcg catatagcat tagaccaaga 60

gaaaatgagt ataaaactat actaactaat ttagacgaat ataataagtt aactacaaac 120

aataatgaaa ataaatattt acaattaaaa aaactaaatg aatcaattga tgtttttatg 180

aataaatata aaacttcaag cagaaataga gcactctcta atctaaaaaa agatatatta 240

aaagaagtaa ttcttattaa aaattccaat acaagccctg tagaaaaaaa tttacatttt 300

gtatggatag gtggagaagt cagtgatatt gctcttgaat acataaaaca atgggctgat 360

attaatgcag aatataatat taaactgtgg tatgatagtg aagcattctt agtaaataca 420

ctaaaaaagg ctatagttga atcttctacc actgaagcat tacagctact agaggaagag 480

540

gatagacaaa aaaggtttat aaattattat aaatctcaaa tcaataaacc tacagtacct 600

acaatagatg atattataaa gtctcatcta gtatctgaat ataatagaga tgaaactgta 660

ttagaatcat atagaacaaa ttctttgaga aaaataaata gtaatcatgg gatagatatc 720

agggctaata gtttgtttac agaacaagag ttattaaata tttatagtca ggagttgtta 780

aatcgtggaa atttagctgc agcatctgac atagtaagat tattagccct aaaaaatttt 840

ggcggagtat atttagcagt tgcaatgctt ccaggtattc actctgattt atttaaaaca 900

atatctagac ctagctctat tggactagac cgttgggaaa tgataaaatt agaggctatt 960

1020

1080

tctaaattag aaaatttaaa tgtatctgat cttgaaatta aaatagcttt cgctttaggc 1140

agtgttataa atcaagcctt gatatcaaaa caaggttcat atcttactaa cctagtaata 1200

1260

1320

gcagaaaact ctatgttttt aacaaaaata

gaagctcgct ccacaataag tttaagtggt ccaggagctt atgcgtcagc ttactatgat 1440

ttcataaatt tacaagaaaa tactatagaa aaaactttaa aagcatcaga tttaatagaa 1500

tttaaattcc cagaaaataa tctatctcaa ttgacagaac aagaaataaa tagtctatgg 1560

1620

ggatctcttt ctgaagacaa tggggtagac tttaataaaa atactgccct cgacaaaaac 1680

tatttattaa ataataaaat tccatcaaac aatgtagaag aagctggaag taaaaattat 1740

1800

ttttctaaaa atcctaaaaa tagtattatt atacaacgaa atatgaatga aagtgcaaaa 1860

agctactttt taagtgatga tggagaatct attttagaat taaataaata taggatacct 1920

gaaagattaa aaaataagga aaaagtaaaa gtaaccttta ttggacatgg taaagatgaa 1980

ttcaacacaa gcgaatttgc tagattaagt gtagattcac tttccaatga gataagttca 2040

tttttagata ccataaaatt agatatatca cctaaaaatg tagaagtaaa cttacttgga 2100

2160

agtattatgg acaaaattac ttccacttta cctgatgtaa ataaaaattc tattactata 2220

ggagcaaatc aatatgaagt aagaattaat agtgagggaa gaaaagaact tctggctcac 2280

tcaggtaaat ggataaataa agaagaagct attatgagcg atttatctag taaagaatac 2340

attttttttg attctataga taataagcta aaagcaaagt ccaagaatat tccaggatta 2400

gcatcaatat cagaagatat aaaaacatta ttacttgatg caagtgttag tcctgataca 2460

aaatttattt taaataatct taagcttaat attgaatctt ctattggtga ttacatttat 2520

tatgaaaaat tagagcctgt taaaaatata attcacaatt ctatagatga tttaatagat 2580

gagttcaatc tacttgaaaa tgtatctgat gaattatatg aattaaaaaa attaaataat 2640

ctagatgaga agtatttaat atcttttgaa gatatctcaa aaaataattc aacttactct 2700

2760

ttttcaaaat atagcgaaca tattacaaaa gaaataagta ctataaagaa tagtataatt 2820

acagatgtta atggtaattt attggataat atacagttag atcatacttc tcaagttaat 2880

acattaaacg cagcattctt tattcaatca ttaatagatt atagtagcaa taaagatgta 2940

ctgaatgatt taagtacctc agttaaggtt caactttatg ctcaactatt tagtacaggt 3000

3060

actataaatg tactacctac aataacagag gggataccta ttgtatctac tatattagac 3120

3180

aaagaattag aagctaaggt gggtgtttta gcaataaata tgtcattatc tatagctgca 3240

actgtagctt caattgttgg aataggtgct gaagttacta ttttcttatt acctatagct 3300

aataatgaat taatattgca tgataaggca 3360

acttcagtgg taaactattt taatcatttg tctgaatcta aaaaatatgg ccctcttaaa 3420

3480

aataataatt cgataaaact aggaacatgt aatatattag caatggaggg gggatcagga 3540

3600

3660

3720

ccaggtttaa gatcattgga aaatgacgga actagattac ttgattcaat aagagattta 3780

tacccaggta aattttactg gagattctat gcttttttcg attatgcaat aactacatta 3840

aaaccagttt atgaagacac taatattaaa attaaactag ataaagatac tagaaacttc 3900

ataatgccaa ctataactac taacgaaatt agaaacaaat tatcttattc atttgatgga 3960

tcatatccaa tatcaacgaa tataaattta 4020

4080

4140

4200

gatagatata tattcttgac ttgtgagtta gatgataaaa ttagtttaat aatagaaata 4260

aatcttgttg caaaatctta tagtttgtta ttgtctgggg ataaaaatta tttgatatcc 4320

aatttatcta atattattga gaaaatcaat actttaggac tagatagtaa aaatatagcg 4380

tacaattaca ctgatgaatc taataataaa tattttggag ctatatctaa aacaagtcaa 4440

4500

acattagaat ttaacagtaa agattttatt gctgaagata taaatgtatt tatgaaagat 4560

gatattaata ctataacagg aaaatactat gttgataata atactgataa aagtatagat 4620

ttctctattt ctttagttag taaaaatcaa gtaaaagtaa atggattata tttaaatgaa 4680

tccgtatact catcttacct tgattttgtg aaaaattcag atggacacca taatacttct 4740

aattttatga atttattttt ggacaatata agttttctgga aattgtttgg gtttgaaaat 4800

ataaattttg taatcgataa atactttacc cttgttggta aaactaatct tggatatgta 4860

gaatttattt gtgacaataa taaaaatata gatatatatt ttggtgaatg gaaaacatcg 4920

4980

aatcctgata cgggtgaaga tatatctact tcactagatt tttcctatga acctctctat 5040

5100

aatattaata ccaattatta ttcaaatgag tactaccctg agattatagt tcttaaccca 5160

aatacattcc acaaaaaagt aaatataaat ttagatagtt cttcttttga gtataaatgg 5220

aagaaagtaa taaaaaaata 5280

ttacaaaaaa taagaatcaa aggtatctta tctaatactc aatcatttaa taaaatgagt 5340

atagatttta aagatattaa aaaactatca ttaggatata taatgagtaa ttttaaatca 5400

tttaattctg aaaatgaatt agatagagat catttaggat ttaaaataat agataataaa 5460

acttattact atgatgaaga tagtaaatta gttaaaggat taatcaatat aaataattca 5520

ttattctatt ttgatcctat agaatttaac ttagtaactg gatggcaaac tatcaatggt 5580

aaaaaatatt attttgatat aaatactgga gcagctttaa ttagttataa aattattaat 5640

ggtaaacact tttattttaa taatgatggt gtgatgcagt tgggagtatt taaaggacct 5700

gatggatttg aatattttgc acctgccaat actcaaaata ataacataga aggtcaggct 5760

atagtttc aaagtaaatt cttaactttg aatggcaaaa aatattattt tgataatgac 5820

tcaaaagcag tcactggatg gagaattatt aacaatgaga aatattactt taatcctaat 5880

aatgctattg ctgcagtcgg attgcaagta attgacaata ataagtatta tttcaatcct 5940

gacactgcta tcatctcaaa aggttggcag actgttaatg gtagtagata ctactttgat 6000

6060

aataggtgtg tttagtacct ctaatggatt tgaatatttt 6120

gcacctgcta atacttataa taataacata gaaggtcagg ctatagttta tcaaagtaaa 6180

6240

tggcaaacta ttgatagtaa aaaatattac tttaatacta acactgctga agcagctact 6300

ggatggcaaa ctattgatgg taaaaaatat tactttaata ctaacactgc tgaagcagct 6360

actggatggc aaactattga tggtaaaaaa tattacttta atactaacac tgctatagct 6420

6480

6540

6600

6660

aagaaatatt actttaatcc taataatgct attgctgcaa ttcatctatg cactataaat 6720

6780

agaaataatt tctattttga tgctaataat gaatctaaaa tggtaacagg agtatttaaa 6840

ggacctaatg gatttgagta ttttgcacct gctaatactc acaataataa catagaaggt 6900

6960

aatgactcaa aagcagttac tggatggcaa accattgatg gtaaaaaata ttactttaat 7020

cttaacactg ctgaagcagc tactggatgg caaactattg atggtaaaaa atattacttt 7080

aatcttaaca ctgctgaagc agctactgga tggcaaacta ttgatggtaa aaaatattac 7140

tttaatacta acactttcat agcctcaact ggttatacaa gtattaatgg taaacatttt 7200

tattttaata ctgatggtat tatgcagata ggagtgttta aaggacctaa tggatttgaa 7260

tactttgcac ctgctaatac tcataataat aacatagaag gtcaagctat actttaccaa 7320

aataaattct taactttgaa tggtaaaaaa tattactttg gtagtgactc aaaagcagtt 7380

accggattgc gaactattga tggtaaaaaa tattacttta atactaacac tgctgttgca 7440

gttactggat ggcaaactat taatggtaaa aaatactact ttaatactaa cacttctata 7500

gcttcaactg gttatacaat tattagtggt aaacattttt attttaatac tgatggtatt 7560

atgcagatag gagtgtttaa aggacctgat ggatttgaat actttgcacc tgctaataca 7620

gatgctaaca atatagaagg tcaagctata cgttatcaaa atagattcct atatttacat 7680

gacaatatat attattttgg taataattca aaagcagcta ctggttgggt aactattgat 7740

ggtaatagat attacttcga gcctaataca gctatggggtg cgaatggtta taaaactatt 7800

7860

aatggatttg aatactttgc acctgctaat acggatgcta acaatataga aggtcaagct 7920

atacgttatc aaaatagatt cctacattta cttggaaaaa tatattactt tggtaataat 7980

tcaaaagcag ttactggatg gcaaactatt aatggtaaag tatattactt tatgcctgat 8040

actgctatgg ctgcagcagg tggacttttc gagattgatg gtgttatata tttctttggt 8100

gttgatggag taaaagcccc tgggatatat ggctaaagat ct 8142

<210> 45

<211> 8136

<212> DNA

<213> Artificial

<220>

<223> Synthetic nucleotide sequence: TcdA gene (mutations

D285A D287A C700A)

<400> 45

catatgtctt taatatctaa agaagagtta ataaaactcg catatagcat tagaccaaga 60

gaaaatgagt ataaaactat actaactaat ttagacgaat ataataagtt aactacaaac 120

aataatgaaa ataaatattt acaattaaaa aaactaaatg aatcaattga tgtttttatg 180

aataaatata aaacttcaag cagaaataga gcactctcta atctaaaaaa agatatatta 240

aaagaagtaa ttcttattaa aaattccaat acaagccctg tagaaaaaaa tttacatttt 300

gtatggatag gtggagaagt cagtgatatt gctcttgaat acataaaaca atgggctgat 360

attaatgcag aatataatat taaactgtgg tatgatagtg aagcattctt agtaaataca 420

ctaaaaaagg ctatagttga atcttctacc actgaagcat tacagctact agaggaagag 480

540

gatagacaaa aaaggtttat aaattattat aaatctcaaa tcaataaacc tacagtacct 600

acaatagatg atattataaa gtctcatcta gtatctgaat ataatagaga tgaaactgta 660

ttagaatcat atagaacaaa ttctttgaga aaaataaata gtaatcatgg gatagatatc 720

agggctaata gtttgtttac agaacaagag ttattaaata tttatagtca ggagttgtta 780

aatcgtggaa atttagctgc agcatctgac atagtaagat tattagccct aaaaaatttt 840

ggcggagtat atttagcagt tgcaatgctt ccaggtattc actctgattt atttaaaaca 900

atatctagac ctagctctat tggactagac cgttgggaaa tgataaaatt agaggctatt 960

1020

1080

tctaaattag aaaatttaaa tgtatctgat cttgaaatta aaatagcttt cgctttaggc 1140

agtgttataa atcaagcctt gatatcaaaa caaggttcat atcttactaa cctagtaata 1200

1260

1320

gcagaaaact ctatgttttt aacaaaaata

gaagctcgct ccacaataag tttaagtggt ccaggagctt atgcgtcagc ttactatgat 1440

ttcataaatt tacaagaaaa tactatagaa aaaactttaa aagcatcaga tttaatagaa 1500

tttaaattcc cagaaaataa tctatctcaa ttgacagaac aagaaataaa tagtctatgg 1560

1620

ggatctcttt ctgaagacaa tggggtagac tttaataaaa atactgccct cgacaaaaac 1680

tatttattaa ataataaaat tccatcaaac aatgtagaag aagctggaag taaaaattat 1740

1800

ttttctaaaa atcctaaaaa tagtattatt atacaacgaa atatgaatga aagtgcaaaa 1860

agctactttt taagtgatga tggagaatct attttagaat taaataaata taggatacct 1920

gaaagattaa aaaataagga aaaagtaaaa gtaaccttta ttggacatgg taaagatgaa 1980

ttcaacacaa gcgaatttgc tagattaagt gtagattcac tttccaatga gataagttca 2040

tttttagata ccataaaatt agatatatca cctaaaaatg tagaagtaaa cttacttgga 2100

2160

agtattatgg acaaaattac ttccacttta cctgatgtaa ataaaaattc tattactata 2220

ggagcaaatc aatatgaagt aagaattaat agtgagggaa gaaaagaact tctggctcac 2280

tcaggtaaat ggataaataa agaagaagct attatgagcg atttatctag taaagaatac 2340

attttttttg attctataga taataagcta aaagcaaagt ccaagaatat tccaggatta 2400

gcatcaatat cagaagatat aaaaacatta ttacttgatg caagtgttag tcctgataca 2460

aaatttattt taaataatct taagcttaat attgaatctt ctattggtga ttacatttat 2520

tatgaaaaat tagagcctgt taaaaatata attcacaatt ctatagatga tttaatagat 2580

gagttcaatc tacttgaaaa tgtatctgat gaattatatg aattaaaaaa attaaataat 2640

ctagatgaga agtatttaat atcttttgaa gatatctcaa aaaataattc aacttactct 2700

2760

ttttcaaaat atagcgaaca tattacaaaa gaaataagta ctataaagaa tagtataatt 2820

acagatgtta atggtaattt attggataat atacagttag atcatacttc tcaagttaat 2880

acattaaacg cagcattctt tattcaatca ttaatagatt atagtagcaa taaagatgta 2940

ctgaatgatt taagtacctc agttaaggtt caactttatg ctcaactatt tagtacaggt 3000

3060

actataaatg tactacctac aataacagag gggataccta ttgtatctac tatattagac 3120

3180

aaagaattag aagctaaggt gggtgtttta gcaataaata tgtcattatc tatagctgca 3240

actgtagctt caattgttgg aataggtgct gaagttacta ttttcttatt acctatagct 3300

aataatgaat taatattgca tgataaggca 3360

acttcagtgg taaactattt taatcatttg tctgaatcta aaaaatatgg ccctcttaaa 3420

3480

aataataatt cgataaaact aggaacatgt aatatattag caatggaggg gggatcagga 3540

3600

3660

3720

ccaggtttaa gatcattgga aaatgacgga actagattac ttgattcaat aagagattta 3780

tacccaggta aattttactg gagattctat gcttttttcg attatgcaat aactacatta 3840

aaaccagttt atgaagacac taatattaaa attaaactag ataaagatac tagaaacttc 3900

ataatgccaa ctataactac taacgaaatt agaaacaaat tatcttattc atttgatgga 3960

tcatatccaa tatcaacgaa tataaattta 4020

4080

4140

4200

gatagatata tattcttgac ttgtgagtta gatgataaaa ttagtttaat aatagaaata 4260

aatcttgttg caaaatctta tagtttgtta ttgtctgggg ataaaaatta tttgatatcc 4320

aatttatcta atattattga gaaaatcaat actttaggac tagatagtaa aaatatagcg 4380

tacaattaca ctgatgaatc taataataaa tattttggag ctatatctaa aacaagtcaa 4440

4500

acattagaat ttaacagtaa agattttatt gctgaagata taaatgtatt tatgaaagat 4560

gatattaata ctataacagg aaaatactat gttgataata atactgataa aagtatagat 4620

ttctctattt ctttagttag taaaaatcaa gtaaaagtaa atggattata tttaaatgaa 4680

tccgtatact catcttacct tgattttgtg aaaaattcag atggacacca taatacttct 4740

aattttatga atttattttt ggacaatata agttttctgga aattgtttgg gtttgaaaat 4800

ataaattttg taatcgataa atactttacc cttgttggta aaactaatct tggatatgta 4860

gaatttattt gtgacaataa taaaaatata gatatatatt ttggtgaatg gaaaacatcg 4920

4980

aatcctgata cgggtgaaga tatatctact tcactagatt tttcctatga acctctctat 5040

5100

aatattaata ccaattatta ttcaaatgag tactaccctg agattatagt tcttaaccca 5160

aatacattcc acaaaaaagt aaatataaat ttagatagtt cttcttttga gtataaatgg 5220

aagaaagtaa taaaaaaata 5280

ttacaaaaaa taagaatcaa aggtatctta tctaatactc aatcatttaa taaaatgagt 5340

atagatttta aagatattaa aaaactatca ttaggatata taatgagtaa ttttaaatca 5400

tttaattctg aaaatgaatt agatagagat catttaggat ttaaaataat agataataaa 5460

acttattact atgatgaaga tagtaaatta gttaaaggat taatcaatat aaataattca 5520

ttattctatt ttgatcctat agaatttaac ttagtaactg gatggcaaac tatcaatggt 5580

aaaaaatatt attttgatat aaatactgga gcagctttaa ttagttataa aattattaat 5640

ggtaaacact tttattttaa taatgatggt gtgatgcagt tgggagtatt taaaggacct 5700

gatggatttg aatattttgc acctgccaat actcaaaata ataacataga aggtcaggct 5760

atagtttc aaagtaaatt cttaactttg aatggcaaaa aatattattt tgataatgac 5820

tcaaaagcag tcactggatg gagaattatt aacaatgaga aatattactt taatcctaat 5880

aatgctattg ctgcagtcgg attgcaagta attgacaata ataagtatta tttcaatcct 5940

gacactgcta tcatctcaaa aggttggcag actgttaatg gtagtagata ctactttgat 6000

6060

aataggtgtg tttagtacct ctaatggatt tgaatatttt 6120

gcacctgcta atacttataa taataacata gaaggtcagg ctatagttta tcaaagtaaa 6180

6240

tggcaaacta ttgatagtaa aaaatattac tttaatacta acactgctga agcagctact 6300

ggatggcaaa ctattgatgg taaaaaatat tactttaata ctaacactgc tgaagcagct 6360

actggatggc aaactattga tggtaaaaaa tattacttta atactaacac tgctatagct 6420

6480

6540

6600

6660

aagaaatatt actttaatcc taataatgct attgctgcaa ttcatctatg cactataaat 6720

6780

agaaataatt tctattttga tgctaataat gaatctaaaa tggtaacagg agtatttaaa 6840

ggacctaatg gatttgagta ttttgcacct gctaatactc acaataataa catagaaggt 6900

6960

aatgactcaa aagcagttac tggatggcaa accattgatg gtaaaaaata ttactttaat 7020

cttaacactg ctgaagcagc tactggatgg caaactattg atggtaaaaa atattacttt 7080

aatcttaaca ctgctgaagc agctactgga tggcaaacta ttgatggtaa aaaatattac 7140

tttaatacta acactttcat agcctcaact ggttatacaa gtattaatgg taaacatttt 7200

tattttaata ctgatggtat tatgcagata ggagtgttta aaggacctaa tggatttgaa 7260

tactttgcac ctgctaatac tcataataat aacatagaag gtcaagctat actttaccaa 7320

aataaattct taactttgaa tggtaaaaaa tattactttg gtagtgactc aaaagcagtt 7380

accggattgc gaactattga tggtaaaaaa tattacttta atactaacac tgctgttgca 7440

gttactggat ggcaaactat taatggtaaa aaatactact ttaatactaa cacttctata 7500

gcttcaactg gttatacaat tattagtggt aaacattttt attttaatac tgatggtatt 7560

atgcagatag gagtgtttaa aggacctgat ggatttgaat actttgcacc tgctaataca 7620

gatgctaaca atatagaagg tcaagctata cgttatcaaa atagattcct atatttacat 7680

gacaatatat attattttgg taataattca aaagcagcta ctggttgggt aactattgat 7740

ggtaatagat attacttcga gcctaataca gctatggggtg cgaatggtta taaaactatt 7800

7860

aatggatttg aatactttgc acctgctaat acggatgcta acaatataga aggtcaagct 7920

atacgttatc aaaatagatt cctacattta cttggaaaaa tatattactt tggtaataat 7980

tcaaaagcag ttactggatg gcaaactatt aatggtaaag tatattactt tatgcctgat 8040

actgctatgg ctgcagcagg tggacttttc gagattgatg gtgttatata tttctttggt 8100

gttgatggag taaaagcccc tgggatatat ggctaa 8136

<210> 46

<211> 7110

<212> DNA

<213> Artificial

<220>

<223> Synthetic nucleotide sequence: TcdB (mutations D286A

D288A)

<400> 46

catatgagtt tagttaatag aaaacagtta gaaaaaatgg caaatgtaag atttcgtact 60

caagaagatg aatatgttgc aatattggat gctttagaag aatatcataa tatgtcagag 120

aatactgtag tcgaaaaata tttaaaatta aaagatataa atagtttaac agatattat 180

atagatacat ataaaaaatc tggtagaaat aaagccttaa aaaaatttaa ggaatatcta 240

gttacagaag tattagagct aaagaataat aatttaactc cagttgagaa aaatttacat 300

tttgtttgga ttggaggtca aataaatgac actgctatta attatataaa tcaatggaaa 360

gatgtaaata gtgattataa tgttaatgtt ttttatgata gtaatgcatt tttgataaac 420

acattgaaaa aaactgtagt agaatcagca ataaatgata cacttgaatc atttagagaa 480

aacttaaatg accctagatt tgactataat aaattcttca gaaaacgtat ggaaataatt 540

tatgataaac agaaaaattt cataaactac tataaagctc aaagagaaga aaatcctgaa 600

cttataattg atgatattgt aaagacatat ctttcaaatg agtattcaaa ggagatagat 660

gaacttaata cctatattga agaatcctta aataaaatta cacagaatag tggaaatgat 720

gttagaaact ttgaagaatt taaaaatgga gagtcattca acttatatga acaagagttg 780

gtagaaaggt ggaatttagc tgctgcttct gacatattaa gaatatctgc attaaaagaa 840

attggtggta tgtatttagc agttgcaatg ttaccaggaa tacaaccaga cttatttgag 900

tctatagaga aacctagttc agtaacagtg gatttttggg aaatgacaaa gttagaagct 960

ataatgaaat acaaagaata tataccagaa tatacctcag aacattttga catgttagac 1020

gaagaagttc aaagtagttt tgaatctgtt ctagcttcta agtcagataa atcagaaata 1080

ttctcatcac ttggtgatat ggaggcatca ccactagaag ttaaaattgc atttaatagt 1140

aagggtatta taaatcaagg gctaatttct gtgaaagact catattgtag caatttaata 1200

gtaaaacaaa tcgagaatag atataaaata ttgaataata gtttaaatcc agctattagc 1260

gaggataatg attttaatac tacaacgaat acctttattg atagtataat ggctgaagct 1320

1380

ccagatgtta aaactactat taacttaagt ggccctgaag cttatgcggc agcttatcaa 1440

gatttattaa tgtttaaaga aggcagtatg aatatccatt tgatagaagc tgatttaaga 1500

aactttgaaa tctctaaaac taatatttct caatcaactg aacaagaaat ggcttcttta 1560

1620

gaaggttctc ttggtgaaga tgataatctt gatttttctc aaaatatagt agttgacaag 1680

gagtatcttt tagaaaaaat atcttcatta gcaagaagtt cagagagagg atatatacac 1740

1800

aagactcctt atgatagtgt actgtttcag aaaaatatag aagattcaga aattgcatat 1860

tattataatc ctggagatgg tgaaatacaa gaaatagaca agtataaaat tccaagtata 1920

atttctgata gacctaagat taaattaaca tttattggtc atggtaaaga tgaatttaat 1980

actgatatat ttgcaggttt tgatgtagat tcattatcca cagaaataga agcagcaata 2040

gatttagcta aagaggatat ttctcctaag tcaatagaaa taaatttatt aggatgtaat 2100

atgtttagct actctatcaa cgtagaggag acttatcctg gaaaattatt acttaaagtt 2160

aaagataaaa tatcagaatt aatgccatct ataagtcaag actctattat agtaagtgca 2220

aatcaatatg aagttagaat aaatagtgaa ggaagaagag aattattgga tcattctggt 2280

catcaaaaga atatatatca 2340

tttaatccta aagaaaataa aattacagta aaatctaaaa atttacctga gctatctaca 2400

ttattacaag aaattagaaa taattctaat tcaagtgata ttgaactaga agaaaaagta 2460

2520

aggattgaag aagctaagaa tttaacttct gactctatta attatataaa agatgaattt 2580

aaactaatag aatctatttc tgatgcacta tgtgacttaa aacaacagaa tgaattagaa 2640

gattctcatt ttatcttt tgaggacata tcagagactg atgagggatt tagtataaga 2700

tttattaata aagaaactgg agaatctata tttgtagaaa ctgaaaaaac aatattctct 2760

gaatatgcta atcatataac tgaagagatt tctaagataa aaggtactat atttgatact 2820

gtaaatggta agttagtaaa aaaagtaaat ttagatacta cacacgaagt aaatacttta 2880

aatgctgcat tttttataca atcattaata gaatataata gttctaaaga atctcttagt 2940

aatttaagtg tagcaatgaa agtccaagtt tacgctcaat tatttagtac tggtttaaat 3000

actattacag atgcagccaa agttgttgaa ttagtatcaa ctgcattaga tgaaactata 3060

3120

acccattatt aagacaagaa 3180

3240

acttcatctt tggggatagc tagtggattt agtatacttt tagttccttt agcaggaatt 3300

3360

3420

3480

aattcaatag ttttaggtaa atgtgaaatc tggagaatgg aaggtggttc aggtcatact 3540

gtaactgatg atatagatca cttcttttca gcaccatcaa taacatatag agagccacac 3600

3660

atggtattac ctaatgctcc aaatagagta tttgcttggg aaacaggatg gacaccaggt 3720

ttaagaagct tagaaaatga tggcacaaaa ctgttagacc gtataagaga taactatgaa 3780

ggtgagtttt attggagata ttttgctttt atagctgatg ctttaataac aacattaaaa 3840

ccaagatatg aagatactaa tataagaata aatttagata gtaatactag aagttttata 3900

gttccaataa taactacaga atatataaga gaaaaattat catattcttt ctatggttca 3960

ggaggaactt atgcattgtc tctttctcaa tataatatgg gtataaatat agaattaagt 4020

gaaagtgatg tttggattat agatgttgat aatgttgtga gagatgtaac tatagaatct 4080

gataaaatta aaaaaggtga tttaatagaa ggtattttat ctacactaag tattgaagag 4140

aataaaatta tcttaaatag ccatgagatt aatttttctg gtgaggtaaa tggaagtaat 4200

ggatttgttt ctttaacatt ttcaatttta gaaggaataa atgcaattat agaagttgat 4260

ttattatcta aatcatataa attacttatt tctggcgaat taaaaatatt gatgttaaat 4320

tcaaatcata ttcaacagaa aatagattat ataggattca atagcgaatt acagaaaaat 4380

ataccatata gctttgtaga tagtgaagga aaagagaatg gttttattaa tggttcaaca 4440

aaagaaggtt tatttgtatc tgaattacct gatgtagttc ttataagtaa ggtttatatg 4500

gatgatagta agccttcatt tggatattat agtaataatt tgaaagatgt caaagttata 4560

actaaagata atgttaatat attaacaggt tattatctta aggatgatat aaaaatctct 4620

ctttctttga ctctacaaga tgaaaaaact ataaagttaa atagtgtgca tttagatgaa 4680

agtggagtag ctgagatttt gaagttcatg aatagaaaag gtaatacaaa tacttcagat 4740

tctttaatga gctttttaga aagtatgaat ataaaaagta ttttcgttaa tttcttacaa 4800

tctaatatta agtttatatt agatgctaat tttataataa gtggtactac ttctattggc 4860

caatttgagt ttatttgtga tgaaaatgat aatatacaac catatttcat taagtttaat 4920

acactagaaa ctaattatac tttatatgta ggaaatagac aaaatatgat agtggaacca 4980

aattatgatt tagatgattc tggagatata tcttcaactg ttatcaattt ctctcaaaag 5040

tatctttatg gaatagacag ttgtgttaat aaagttgtaa tttcaccaaa tatttataca 5100

5160

ttagatgcaa attatataaa tgaaaaaata aatgttaata tcaatgatct atctatacga 5220

tatgtatgga gtaatgatgg taatgatttt attcttatgt caactagtga agaaaataag 5280

gtgtcacaag ttaaaataag attcgttaat gtttttaaag ataagacttt ggcaaataag 5340

ctatctttta actttagtga taaacaagat gtacctgtaa gtgaaataat cttatcattt 5400

5460

aatgagaaat tttatattaa taactttgga atgatggtat ctggattaat atatattaat 5520

5580

ggcgatgata aatactactt taatccaatt aatggtggag ctgcttcaat tggagagaca 5640

ataattgatg acaaaaatta ttatttcaac caaagtggag tgttacaaac aggtgtattt 5700

agtacagaag atggatttaa atattttgcc ccagctaata cacttgatga aaacctagaa 5760

5820

gataattata gaggagctgt agaatggaaa gaattagatg gtgaaatgca ctattttagc 5880

ccagaaacag gtaaagcttt taaaggtcta aatcaaatag gtgattataa atactatttc 5940

6000

6060

6120

gctcatcata atgaagattt aggaaatgaa gaaggtgaag aaatctcata ttctggtata 6180

ttaaatttca ataataaaat ttactatttt gatgattcat ttactgctgt agttggatgg 6240

6300

6360

ggatttgtca ctataaatga taaagtcttc tacttctctg actctggaat tatagaatct 6420

ggagtacaaa acatagatga caattatttc tatatagatg ataatggtat agttcaaatt 6480

ggtgtatttg atacttcaga tggatataaa tattttgcac ctgctaatac tgtaaatgat 6540

6600

6660

6720

gatataaaat attattttga tgagaagggc ataatgagaa cgggtcttat atcatttgaa 6780

6840

gataagatgt tctattttgg tgaagatggt gtcatgcaga ttggagtatt taatacacca 6900

gatggattta aatactttgc acatcaaaat actttggatg agaattttga gggagaatca 6960

ataaactata ctggttggtt agatttagat gaaaagagat attattttac agatgaatat 7020

attgcagcaa ctggttcagt tattattgat ggtgaggagt

gctcaattag tgattagtga atagagatct 7110

<210> 47

<211> 7104

<212> DNA

<213> Artificial

<220>

<223> Synthetic nucleotide sequence: TcdB (mutations D286A

D288A C698A)

<400> 47

catatgagtt tagttaatag aaaacagtta gaaaaaatgg caaatgtaag atttcgtact 60

caagaagatg aatatgttgc aatattggat gctttagaag aatatcataa tatgtcagag 120

aatactgtag tcgaaaaata tttaaaatta aaagatataa atagtttaac agatattat 180

atagatacat ataaaaaatc tggtagaaat aaagccttaa aaaaatttaa ggaatatcta 240

gttacagaag tattagagct aaagaataat aatttaactc cagttgagaa aaatttacat 300

tttgtttgga ttggaggtca aataaatgac actgctatta attatataaa tcaatggaaa 360

gatgtaaata gtgattataa tgttaatgtt ttttatgata gtaatgcatt tttgataaac 420

acattgaaaa aaactgtagt agaatcagca ataaatgata cacttgaatc atttagagaa 480

aacttaaatg accctagatt tgactataat aaattcttca gaaaacgtat ggaaataatt 540

tatgataaac agaaaaattt cataaactac tataaagctc aaagagaaga aaatcctgaa 600

cttataattg atgatattgt aaagacatat ctttcaaatg agtattcaaa ggagatagat 660

gaacttaata cctatattga agaatcctta aataaaatta cacagaatag tggaaatgat 720

gttagaaact ttgaagaatt taaaaatgga gagtcattca acttatatga acaagagttg 780

gtagaaaggt ggaatttagc tgctgcttct gacatattaa gaatatctgc attaaaagaa 840

attggtggta tgtatttagc agttgcaatg ttaccaggaa tacaaccaga cttatttgag 900

tctatagaga aacctagttc agtaacagtg gatttttggg aaatgacaaa gttagaagct 960

ataatgaaat acaaagaata tataccagaa tatacctcag aacattttga catgttagac 1020

gaagaagttc aaagtagttt tgaatctgtt ctagcttcta agtcagataa atcagaaata 1080

ttctcatcac ttggtgatat ggaggcatca ccactagaag ttaaaattgc atttaatagt 1140

aagggtatta taaatcaagg gctaatttct gtgaaagact catattgtag caatttaata 1200

gtaaaacaaa tcgagaatag atataaaata ttgaataata gtttaaatcc agctattagc 1260

gaggataatg attttaatac tacaacgaat acctttattg atagtataat ggctgaagct 1320

1380

ccagatgtta aaactactat taacttaagt ggccctgaag cttatgcggc agcttatcaa 1440

gatttattaa tgtttaaaga aggcagtatg aatatccatt tgatagaagc tgatttaaga 1500

aactttgaaa tctctaaaac taatatttct caatcaactg aacaagaaat ggcttcttta 1560

1620

gaaggttctc ttggtgaaga tgataatctt gatttttctc aaaatatagt agttgacaag 1680

gagtatcttt tagaaaaaat atcttcatta gcaagaagtt cagagagagg atatatacac 1740

1800

aagactcctt atgatagtgt actgtttcag aaaaatatag aagattcaga aattgcatat 1860

tattataatc ctggagatgg tgaaatacaa gaaatagaca agtataaaat tccaagtata 1920

atttctgata gacctaagat taaattaaca tttattggtc atggtaaaga tgaatttaat 1980

actgatatat ttgcaggttt tgatgtagat tcattatcca cagaaataga agcagcaata 2040

gatttagcta aagaggatat ttctcctaag tcaatagaaa taaatttatt aggagctaat 2100

atgtttagct actctatcaa cgtagaggag acttatcctg gaaaattatt acttaaagtt 2160

aaagataaaa tatcagaatt aatgccatct ataagtcaag actctattat agtaagtgca 2220

aatcaatatg aagttagaat aaatagtgaa ggaagaagag aattattgga tcattctggt 2280

catcaaaaga atatatatca 2340

tttaatccta aagaaaataa aattacagta aaatctaaaa atttacctga gctatctaca 2400

ttattacaag aaattagaaa taattctaat tcaagtgata ttgaactaga agaaaaagta 2460

2520

aggattgaag aagctaagaa tttaacttct gactctatta attatataaa agatgaattt 2580

aaactaatag aatctatttc tgatgcacta tgtgacttaa aacaacagaa tgaattagaa 2640

gattctcatt ttatcttt tgaggacata tcagagactg atgagggatt tagtataaga 2700

tttattaata aagaaactgg agaatctata tttgtagaaa ctgaaaaaac aatattctct 2760

gaatatgcta atcatataac tgaagagatt tctaagataa aaggtactat atttgatact 2820

gtaaatggta agttagtaaa aaaagtaaat ttagatacta cacacgaagt aaatacttta 2880

aatgctgcat tttttataca atcattaata gaatataata gttctaaaga atctcttagt 2940

aatttaagtg tagcaatgaa agtccaagtt tacgctcaat tatttagtac tggtttaaat 3000

actattacag atgcagccaa agttgttgaa ttagtatcaa ctgcattaga tgaaactata 3060

3120

acccattatt aagacaagaa 3180

3240

acttcatctt tggggatagc tagtggattt agtatacttt tagttccttt agcaggaatt 3300

3360

3420

3480

aattcaatag ttttaggtaa atgtgaaatc tggagaatgg aaggtggttc aggtcatact 3540

gtaactgatg atatagatca cttcttttca gcaccatcaa taacatatag agagccacac 3600

3660

atggtattac ctaatgctcc aaatagagta tttgcttggg aaacaggatg gacaccaggt 3720

ttaagaagct tagaaaatga tggcacaaaa ctgttagacc gtataagaga taactatgaa 3780

ggtgagtttt attggagata ttttgctttt atagctgatg ctttaataac aacattaaaa 3840

ccaagatatg aagatactaa tataagaata aatttagata gtaatactag aagttttata 3900

gttccaataa taactacaga atatataaga gaaaaattat catattcttt ctatggttca 3960

ggaggaactt atgcattgtc tctttctcaa tataatatgg gtataaatat agaattaagt 4020

gaaagtgatg tttggattat agatgttgat aatgttgtga gagatgtaac tatagaatct 4080

gataaaatta aaaaaggtga tttaatagaa ggtattttat ctacactaag tattgaagag 4140

aataaaatta tcttaaatag ccatgagatt aatttttctg gtgaggtaaa tggaagtaat 4200

ggatttgttt ctttaacatt ttcaatttta gaaggaataa atgcaattat agaagttgat 4260

ttattatcta aatcatataa attacttatt tctggcgaat taaaaatatt gatgttaaat 4320

tcaaatcata ttcaacagaa aatagattat ataggattca atagcgaatt acagaaaaat 4380

ataccatata gctttgtaga tagtgaagga aaagagaatg gttttattaa tggttcaaca 4440

aaagaaggtt tatttgtatc tgaattacct gatgtagttc ttataagtaa ggtttatatg 4500

gatgatagta agccttcatt tggatattat agtaataatt tgaaagatgt caaagttata 4560

actaaagata atgttaatat attaacaggt tattatctta aggatgatat aaaaatctct 4620

ctttctttga ctctacaaga tgaaaaaact ataaagttaa atagtgtgca tttagatgaa 4680

agtggagtag ctgagatttt gaagttcatg aatagaaaag gtaatacaaa tacttcagat 4740

tctttaatga gctttttaga aagtatgaat ataaaaagta ttttcgttaa tttcttacaa 4800

tctaatatta agtttatatt agatgctaat tttataataa gtggtactac ttctattggc 4860

caatttgagt ttatttgtga tgaaaatgat aatatacaac catatttcat taagtttaat 4920

acactagaaa ctaattatac tttatatgta ggaaaatagac aaaatatgat agtggaacca 4980

aattatgatt tagatgattc tggagatata tcttcaactg ttatcaattt ctctcaaaag 5040

tatctttatg gaatagacag ttgtgttaat aaagttgtaa tttcaccaaa tatttataca 5100

5160

ttagatgcaa attatataaa tgaaaaaata aatgttaata tcaatgatct atctatacga 5220

tatgtatgga gtaatgatgg taatgatttt attcttatgt caactagtga agaaaataag 5280

gtgtcacaag ttaaaataag attcgttaat gtttttaaag ataagacttt ggcaaataag 5340

ctatctttta actttagtga taaacaagat gtacctgtaa gtgaaataat cttatcattt 5400

5460

aatgagaaat tttatattaa taactttgga atgatggtat ctggattaat atatattaat 5520

5580

ggcgatgata aatactactt taatccaatt aatggtggag ctgcttcaat tggagagaca 5640

ataattgatg acaaaaatta ttatttcaac caaagtggag tgttacaaac aggtgtattt 5700

agtacagaag atggatttaa atattttgcc ccagctaata cacttgatga aaacctagaa 5760

5820

gataattata gaggagctgt agaatggaaa gaattagatg gtgaaatgca ctattttagc 5880

ccagaaacag gtaaagcttt taaaggtcta aatcaaatag gtgattataa atactatttc 5940

6000

6060

6120

gctcatcata atgaagattt aggaaatgaa gaaggtgaag aaatctcata ttctggtata 6180

ttaaatttca ataataaaat ttactatttt gatgattcat ttactgctgt agttggatgg 6240

6300

6360

ggatttgtca ctataaatga taaagtcttc tacttctctg actctggaat tatagaatct 6420

ggagtacaaa acatagatga caattatttc tatatagatg ataatggtat agttcaaatt 6480

ggtgtatttg atacttcaga tggatataaa tattttgcac ctgctaatac tgtaaatgat 6540

6600

6660

6720

gatataaaat attattttga tgagaagggc ataatgagaa cgggtcttat atcatttgaa 6780

6840

gataagatgt tctattttgg tgaagatggt gtcatgcaga ttggagtatt taatacacca 6900

gatggattta aatactttgc acatcaaaat actttggatg agaattttga gggagaatca 6960

ataaactata ctggttggtt agatttagat gaaaagagat attattttac agatgaatat 7020

attgcagcaa ctggttcagt tattattgat ggtgaggagt

gctcaattag tgattagtga atag 7104

<210> 48

<211> 21

<212> DNA

<213> Artificial sequence

<220>

<223> Synthetic nucleic acid sequence

<400> 48

tcgtcgtttt tcggtgcttt t 21

<210> 49

<211> 118

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 49

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala

1 5 10 15

Pro Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr

20 25 30

Trp Met Asn Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile

35 40 45

Gly Arg Ile Asp Pro Ser Asn Ser Glu Ile Tyr Tyr Asn Gln Lys Phe

50 55 60

Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr

65 70 75 80

Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys

85 90 95

Ala Ser Gly His Tyr Gly Ser Ile Phe Ala Tyr Trp Gly Gln Gly Thr

100 105 110

Thr Leu Thr Val Ser Ser

115

<210> 50

<211> 19

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 50

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly

1 5 10 15

Val His Ser

<210> 51

<211> 10

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 51

Gly Tyr Ser Phe Thr Ser Tyr Trp Met Asn

1 5 10

<210> 52

<211> 15

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 52

Arg Ile Asp Pro Ser Asn Ser Glu Ile Tyr Tyr Asn Gln Lys Phe

1 5 10 15

<210> 53

<211> 9

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 53

Gly His Tyr Gly Ser Ile Phe Ala Tyr

fifteen

<210> 54

<211> 17

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 54

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Asn Ser

1 5 10 15

Lys

<210> 55

<211> 125

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 55

Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly Glu

1 5 10 15

Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu

20 25 30

Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Leu Tyr

35 40 45

Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser

50 55 60

Arg Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Ser Leu Glu Pro Glu

65 70 75 80

Asp Ser Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu Thr

85 90 95

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro

100 105 110

Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Glu Phe Gln

115 120 125

<210> 56

<211> 21

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 56

Met Arg Phe Gln Val Gln Val Leu Gly Leu Leu Leu Leu Trp Ile Ser

1 5 10 15

Gly Ala Gln Cys Asp

twenty

<210> 57

<211> 11

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 57

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala

1 5 10

<210> 58

<211> 7

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 58

Ser Gly Ser Thr Leu Gln Ser

fifteen

<210> 59

<211> 9

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 59

Gln Gln His Asn Glu Tyr Pro Leu Thr

fifteen

<210> 60

<211> 121

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 60

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala

1 5 10 15

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr

20 25 30

Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Asn Pro Ser Asn Gly Arg Ser Thr Tyr Ser Glu Lys Phe

50 55 60

Lys Thr Thr Ala Thr Val Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr

65 70 75 80

Met Gln Leu Ser Ile Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys

85 90 95

Ala Arg Ala Tyr Tyr Ser Thr Ser Tyr Tyr Ala Met Asp Tyr Trp Gly

100 105 110

Gln Gly Thr Ser Val Thr Val Ser Ser

115 120

<210> 61

<211> 19

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 61

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp

1 5 10 15

Val His Ser

<210> 62

<211> 10

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 62

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His

1 5 10

<210> 63

<211> 15

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 63

Val Ile Asn Pro Ser Asn Gly Arg Ser Thr Tyr Ser Glu Lys Phe

1 5 10 15

<210> 64

<211> 12

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 64

Ala Tyr Tyr Ser Thr Ser Tyr Tyr Ala Met Asp Tyr

1 5 10

<210> 65

<211> 17

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 65

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Asn Ser

1 5 10 15

Lys

<210> 66

<211> 130

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 66

Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp

1 5 10 15

Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser Asn

20 25 30

Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro

35 40 45

Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp

50 55 60

Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile Ser

65 70 75 80

Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser

85 90 95

His Phe Pro Phe Thr Phe Gly Thr Gly Thr Lys Leu Glu Ile Lys Arg

100 105 110

Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Glu

115 120 125

Phe Gln

130

<210> 67

<211> 20

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 67

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala

1 5 10 15

Ser Ser Ser Asp

twenty

<210> 68

<211> 16

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 68

Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu

1 5 10 15

<210> 69

<211> 7

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 69

Lys Val Ser Asn Arg Phe Ser

fifteen

<210> 70

<211> 9

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 70

Phe Gln Gly Ser His Phe Pro Phe Thr

fifteen

<210> 71

<211> 118

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 71

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala

1 5 10 15

Pro Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr

20 25 30

Trp Met Asn Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile

35 40 45

Gly Arg Ile Asp Pro Ser Asn Ser Glu Ile Tyr Tyr Asn Gln Lys Phe

50 55 60

Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr

65 70 75 80

Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys

85 90 95

Ala Ser Gly His Tyr Gly Ser Ile Phe Ala Tyr Trp Gly Gln Gly Thr

100 105 110

Thr Leu Thr Val Ser Ser

115

<210> 72

<211> 19

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 72

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly

1 5 10 15

Val His Ser

<210> 73

<211> 10

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 73

Gly Tyr Pro Phe Thr Asn Tyr Trp Met Asn

1 5 10

<210> 74

<211> 15

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 74

Arg Ile Asp Pro Ser Asn Ser Glu Ile Tyr Tyr Asn Gln Lys Phe

1 5 10 15

<210> 75

<211> 9

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 75

Gly His Tyr Gly Ser Ile Phe Ala Tyr

fifteen

<210> 76

<211> 17

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 76

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Asn Ser

1 5 10 15

Lys

<210> 77

<211> 125

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 77

Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly Glu

1 5 10 15

Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu

20 25 30

Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile Tyr

35 40 45

Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser

50 55 60

Arg Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Ser Leu Glu Pro Glu

65 70 75 80

Asp Ser Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu Thr

85 90 95

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro

100 105 110

Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Glu Phe Gln

115 120 125

<210> 78

<211> 21

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 78

Met Arg Phe Gln Val Gln Val Leu Gly Leu Leu Leu Leu Trp Ile Ser

1 5 10 15

Gly Ala Gln Cys Asp

twenty

<210> 79

<211> 11

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 79

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala

1 5 10

<210> 80

<211> 7

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 80

Ser Gly Ser Thr Leu Gln Ser

fifteen

<210> 81

<211> 9

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 81

Gln Gln His Asn Glu Tyr Pro Leu Thr

fifteen

<210> 82

<211> 2366

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<220>

<221> OTHER_INDICATOR

<222> (102)..(102)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (270)..(270)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (273)..(273)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (286)..(286)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (288)..(288)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (384)..(384)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (461)..(461)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (463)..(463)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (520)..(520)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (543)..(543)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (544)..(544)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (587)..(587)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (600)..(600)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (653)..(653)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (698)..(698)

<223> Xaa is any amino acid.

<220>

<221> OTHER_INDICATOR

<222> (751)..(751)

<223> Xaa is any amino acid.

<400> 82

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Xaa Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Xaa Ile Leu

260 265 270

Xaa Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Xaa Val Xaa

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Xaa

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Xaa Val Xaa Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Xaa Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Xaa Xaa

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Xaa Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Xaa Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly Xaa Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Xaa Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Xaa Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 83

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 83

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Ala Ile Val Ala Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Ala Ala Ala Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 84

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 84

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 85

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 85

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Ala Val Ala Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 86

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 86

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 87

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 87

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 88

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 88

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 89

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 89

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 90

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 90

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 91

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 91

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 92

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 92

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 93

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 93

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Thr Asn Thr Ala Glu Thr Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Asp Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 94

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 94

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 95

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 95

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Asp Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 96

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 96

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 97

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 97

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 98

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 98

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 99

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 99

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Asp Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 100

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 100

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Lys Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 101

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 101

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Asp Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 102

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 102

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Leu Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 103

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 103

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Leu Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 104

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 104

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Leu Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 105

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 105

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 106

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 106

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 107

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 107

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 108

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 108

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 109

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 109

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 110

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 110

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr

180 185 190

Gln Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser

1115 1120 1125

Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu

1325 1330 1335

Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Ser Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys

1490 1495 1500

Pro Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys

1715 1720 1725

Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly

1760 1765 1770

Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu

1865 1870 1875

Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe

1925 1930 1935

Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp

1940 1945 1950

Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile

2090 2095 2100

Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln

2105 2110 2115

Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp

2255 2260 2265

Gly Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe

2270 2275 2280

Tyr Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 111

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 111

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 112

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 112

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr

180 185 190

Gln Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser

1115 1120 1125

Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu

1325 1330 1335

Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Ser Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys

1490 1495 1500

Pro Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys

1715 1720 1725

Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly

1760 1765 1770

Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu

1865 1870 1875

Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe

1925 1930 1935

Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp

1940 1945 1950

Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile

2090 2095 2100

Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln

2105 2110 2115

Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp

2255 2260 2265

Gly Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe

2270 2275 2280

Tyr Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 113

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 113

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 114

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 114

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Arg Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 115

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 115

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 116

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 116

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 117

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 117

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 118

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 118

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 119

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 119

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr

180 185 190

Gln Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser

1115 1120 1125

Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu

1325 1330 1335

Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Ser Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys

1490 1495 1500

Pro Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys

1715 1720 1725

Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly

1760 1765 1770

Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu

1865 1870 1875

Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe

1925 1930 1935

Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp

1940 1945 1950

Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile

2090 2095 2100

Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln

2105 2110 2115

Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp

2255 2260 2265

Gly Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe

2270 2275 2280

Tyr Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 120

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 120

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Asp Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 121

<211> 2367

<212> PROTEIN

<213> Clostridium difficile

<400> 121

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Ile Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met

165 170 175

Gln Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu

260 265 270

Arg Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro

290 295 300

Asp Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala

305 310 315 320

Ile Met Lys His Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe

325 330 335

Asp Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala

340 345 350

Ser Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu

355 360 365

Val Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile

370 375 380

Asn Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu

385 390 395 400

Ile Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly

405 410 415

Pro Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe

420 425 430

Gly Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile

435 440 445

Ala Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn

450 455 460

Thr Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys

465 470 475 480

Asp Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser

485 490 495

Ser Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala

500 505 510

Thr Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala

515 520 525

Lys Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Thr Asp Lys

545 550 555 560

Glu Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg

565 570 575

Gly Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr

580 585 590

Glu Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu

595 600 605

Phe Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro

610 615 620

Thr Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg

625 630 635 640

Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys

645 650 655

Ala Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu

660 665 670

Ser Ser Glu Ile Glu Thr Ala Ile Gly Leu Ala Lys Glu Asp Ile Ser

675 680 685

Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Ser Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val

705 710 715 720

Lys Asp Lys Val Ser Glu Leu Met Pro Ser Met Ser Gln Asp Ser Ile

725 730 735

Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser

755 760 765

Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys

770 775 780

Glu Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr

785 790 795 800

Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu

805 810 815

Glu Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn

820 825 830

Ile Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu

835 840 845

Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu

850 855 860

Ser Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu

865 870 875 880

Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly

885 890 895

Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val

900 905 910

Glu Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu

915 920 925

Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys

930 935 940

Leu Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys

965 970 975

Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val

995 1000 1005

Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu

1010 1015 1020

Pro Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp

1025 1030 1035

Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser

1040 1045 1050

Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met

1055 1060 1065

Ala Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser

1070 1075 1080

Leu Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val

1100 1105 1110

Leu Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val

1115 1120 1125

Ser Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys

1130 1135 1140

Val Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe

1175 1180 1185

Phe Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile

1190 1195 1200

Tyr Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys

1205 1210 1215

Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp

1220 1225 1230

Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe

1250 1255 1260

Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr

1265 1270 1275

Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp

1280 1285 1290

Ser Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr

1295 1300 1305

Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr

1310 1315 1320

Tyr Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu

1325 1330 1335

Leu Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val

1340 1345 1350

Arg Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu

1355 1360 1365

Ile Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile

1370 1375 1380

Ile Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly

1385 1390 1395

Ser Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile

1400 1405 1410

Asn Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu

1415 1420 1425

Leu Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His

1430 1435 1440

Ile Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln

1445 1450 1455

Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn

1460 1465 1470

Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu

1475 1480 1485

Leu Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser

1490 1495 1500

Lys Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys

1505 1510 1515

Val Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu

1520 1525 1530

Lys Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu

1535 1540 1545

Lys Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val

1550 1555 1560

Ala Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr

1565 1570 1575

Ser Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser

1580 1585 1590

Ile Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp

1595 1600 1605

Ala Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu

1610 1615 1620

Phe Ile Cys Asp Glu Asn Asn Asn Ile Gln Pro Tyr Phe Ile Lys

1625 1630 1635

Phe Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg

1640 1645 1650

Gln Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly

1655 1660 1665

Asp Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr

1670 1675 1680

Gly Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile

1685 1690 1695

Tyr Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn

1700 1705 1710

Thr Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu

1715 1720 1725

Lys Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp

1730 1735 1740

Ser Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu

1745 1750 1755

Asn Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys

1760 1765 1770

Asp Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys

1775 1780 1785

Gln Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser

1790 1795 1800

Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser

1805 1810 1815

Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val

1820 1825 1830

Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro

1835 1840 1845

Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp

1850 1855 1860

Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly

1865 1870 1875

Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

1880 1885 1890

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr

1895 1900 1905

Phe Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala

1910 1915 1920

Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr

1925 1930 1935

Phe Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp

1940 1945 1950

Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys

1955 1960 1965

Gly Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp

1970 1975 1980

Gly Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His

1985 1990 1995

Tyr Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile

2000 2005 2010

Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile

2015 2020 2025

Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His

2030 2035 2040

Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser

2045 2050 2055

Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser

2060 2065 2070

Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys

2075 2080 2085

Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser

2090 2095 2100

Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met

2105 2110 2115

Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

2120 2125 2130

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn

2135 2140 2145

Tyr Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe

2150 2155 2160

Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val

2165 2170 2175

Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val

2180 2185 2190

Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile

2195 2200 2205

Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr

2210 2215 2220

Tyr Phe Asp Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu

2225 2230 2235

Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg

2240 2245 2250

Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu

2255 2260 2265

Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met

2270 2275 2280

Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn

2285 2290 2295

Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp

2300 2305 2310

Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp

2315 2320 2325

Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala

2330 2335 2340

Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro

2345 2350 2355

Asp Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 122

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 122

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 123

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 123

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 124

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 124

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 125

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 125

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 126

<211> 2367

<212> PROTEIN

<213> Clostridium difficile

<400> 126

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met

165 170 175

Gln Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu

260 265 270

Arg Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro

290 295 300

Asp Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala

305 310 315 320

Ile Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe

325 330 335

Asp Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala

340 345 350

Ser Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu

355 360 365

Val Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile

370 375 380

Asn Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu

385 390 395 400

Ile Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly

405 410 415

Pro Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe

420 425 430

Gly Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile

435 440 445

Ala Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn

450 455 460

Thr Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys

465 470 475 480

Asp Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser

485 490 495

Ser Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala

500 505 510

Thr Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala

515 520 525

Lys Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Ile Asp Lys

545 550 555 560

Glu Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg

565 570 575

Gly Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr

580 585 590

Glu Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu

595 600 605

Phe Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro

610 615 620

Thr Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg

625 630 635 640

Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Leu Ile Gly His Gly Lys

645 650 655

Ala Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu

660 665 670

Ser Ser Glu Ile Glu Thr Ile Ile Asp Leu Ala Lys Ala Asp Ile Ser

675 680 685

Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Ser Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val

705 710 715 720

Lys Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile

725 730 735

Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser

755 760 765

Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys

770 775 780

Glu Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr

785 790 795 800

Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu

805 810 815

Glu Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn

820 825 830

Ile Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu

835 840 845

Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu

850 855 860

Ser Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu

865 870 875 880

Glu Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly

885 890 895

Phe Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val

900 905 910

Glu Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu

915 920 925

Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys

930 935 940

Leu Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys

965 970 975

Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val

995 1000 1005

Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu

1010 1015 1020

Pro Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp

1025 1030 1035

Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser

1040 1045 1050

Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met

1055 1060 1065

Ala Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser

1070 1075 1080

Leu Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile

1115 1120 1125

Ser Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys

1130 1135 1140

Ile Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile

1190 1195 1200

Tyr Asp Val Leu Glu Val Lys Lys Glu Glu Leu Asp Leu Ser Lys

1205 1210 1215

Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Gly Trp

1220 1225 1230

Glu Thr Gly Trp Thr Pro Gly Leu Arg Gly Leu Glu Asn Asp Gly

1235 1240 1245

Thr Lys Leu Leu Asp Arg Ile Arg Asp Gln Tyr Glu Gly Gln Phe

1250 1255 1260

Tyr Trp Arg Phe Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr

1265 1270 1275

Leu Lys Pro Arg Tyr Glu Asp Thr Asn Val Arg Ile Ser Leu Asp

1280 1285 1290

Ser Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr

1295 1300 1305

Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr

1310 1315 1320

Tyr Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu

1325 1330 1335

Leu Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val

1340 1345 1350

Arg Ser Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu

1355 1360 1365

Ile Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile

1370 1375 1380

Ile Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly

1385 1390 1395

Gly Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile

1400 1405 1410

Asn Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val

1415 1420 1425

Leu Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser

1430 1435 1440

Val Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln

1445 1450 1455

Lys Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn

1460 1465 1470

Gly Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu

1475 1480 1485

Leu Ser Asp Val Val Leu Ile Ile Lys Val Tyr Met Asp Asn Ser

1490 1495 1500

Lys Pro Pro Phe Gly Tyr Tyr Ser Asn Asp Leu Lys Asp Val Lys

1505 1510 1515

Ala Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu

1520 1525 1530

Lys Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Lys

1535 1540 1545

Asn Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val

1550 1555 1560

Ala Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr

1565 1570 1575

Ser Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser

1580 1585 1590

Ile Phe Ile Lys Ser Leu Lys Ser Asn Ala Lys Leu Ile Leu Asp

1595 1600 1605

Thr Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu

1610 1615 1620

Phe Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys

1625 1630 1635

Phe Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg

1640 1645 1650

Gln Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly

1655 1660 1665

Asp Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr

1670 1675 1680

Gly Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile

1685 1690 1695

Tyr Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn

1700 1705 1710

Thr Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu

1715 1720 1725

Lys Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp

1730 1735 1740

Ser Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu

1745 1750 1755

Asn Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys

1760 1765 1770

Gly Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys

1775 1780 1785

Gln Asp Val Ser Ile Asn Lys Ile Ile Ser Thr Phe Thr Pro Ser

1790 1795 1800

Tyr Tyr Val Glu Gly Leu Leu Asn Tyr His Leu Gly Leu Ile Ser

1805 1810 1815

Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val

1820 1825 1830

Ser Gly Leu Val Tyr Ile Asp Ser Leu Tyr Tyr Phe Lys Pro

1835 1840 1845

Pro Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp

1850 1855 1860

Lys Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly

1865 1870 1875

Glu Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Pro Asn Gly

1880 1885 1890

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr

1895 1900 1905

Phe Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala

1910 1915 1920

Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Val Tyr Tyr

1925 1930 1935

Phe Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp

1940 1945 1950

Asp Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys

1955 1960 1965

Gly Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp

1970 1975 1980

Gly Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe

1985 1990 1995

Tyr Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile

2000 2005 2010

Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile

2015 2020 2025

Gly Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His

2030 2035 2040

Asp Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser

2045 2050 2055

Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser

2060 2065 2070

Phe Thr Ala Val Val Gly Trp Lys Asp Ser Glu Asp Gly Ser Lys

2075 2080 2085

Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser

2090 2095 2100

Thr Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met

2105 2110 2115

Gln Ile Gly Phe Val Thr Ile Asn Glu Val Phe Tyr Phe Ser

2120 2125 2130

Asp Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn

2135 2140 2145

Tyr Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe

2150 2155 2160

Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val

2165 2170 2175

Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val

2180 2185 2190

Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile

2195 2200 2205

Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr

2210 2215 2220

Tyr Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val

2225 2230 2235

Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg

2240 2245 2250

Thr Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu

2255 2260 2265

Asp Gly Ile Met Gln Tyr Gly Tyr Ile Asn Ile Glu Asp Lys Met

2270 2275 2280

Phe Tyr Phe Asn Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn

2285 2290 2295

Thr Ala Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp

2300 2305 2310

Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp

2315 2320 2325

Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala

2330 2335 2340

Ile Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro

2345 2350 2355

Asp Thr Ala Glu Leu Val Ile Ser Glu

2360 2365

<210> 127

<211> 2367

<212> PROTEIN

<213> Clostridium difficile

<400> 127

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met

165 170 175

Gln Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu

260 265 270

Arg Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro

290 295 300

Asp Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala

305 310 315 320

Ile Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe

325 330 335

Asp Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala

340 345 350

Ser Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu

355 360 365

Val Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile

370 375 380

Asn Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu

385 390 395 400

Ile Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly

405 410 415

Pro Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe

420 425 430

Gly Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile

435 440 445

Ala Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn

450 455 460

Thr Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys

465 470 475 480

Asp Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser

485 490 495

Ser Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala

500 505 510

Thr Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala

515 520 525

Lys Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Ile Asp Lys

545 550 555 560

Glu Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg

565 570 575

Gly Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr

580 585 590

Glu Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu

595 600 605

Phe Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro

610 615 620

Thr Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg

625 630 635 640

Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Leu Ile Gly His Gly Lys

645 650 655

Ala Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu

660 665 670

Ser Ser Glu Ile Glu Thr Ile Ile Asp Leu Ala Lys Ala Asp Ile Ser

675 680 685

Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Ser Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val

705 710 715 720

Lys Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile

725 730 735

Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser

755 760 765

Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys

770 775 780

Glu Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr

785 790 795 800

Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu

805 810 815

Glu Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn

820 825 830

Ile Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu

835 840 845

Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu

850 855 860

Ser Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu

865 870 875 880

Glu Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly

885 890 895

Phe Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val

900 905 910

Glu Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu

915 920 925

Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys

930 935 940

Leu Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys

965 970 975

Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val

995 1000 1005

Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu

1010 1015 1020

Pro Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp

1025 1030 1035

Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser

1040 1045 1050

Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met

1055 1060 1065

Ala Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser

1070 1075 1080

Leu Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile

1115 1120 1125

Ser Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys

1130 1135 1140

Ile Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile

1190 1195 1200

Tyr Asp Val Leu Glu Val Lys Lys Glu Glu Leu Asp Leu Ser Lys

1205 1210 1215

Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Gly Trp

1220 1225 1230

Glu Thr Gly Trp Thr Pro Gly Leu Arg Gly Leu Glu Asn Asp Gly

1235 1240 1245

Thr Lys Leu Leu Asp Arg Ile Arg Asp Gln Tyr Glu Gly Gln Phe

1250 1255 1260

Tyr Trp Arg Phe Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr

1265 1270 1275

Leu Lys Pro Arg Tyr Glu Asp Thr Asn Val Arg Ile Ser Leu Asp

1280 1285 1290

Ser Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr

1295 1300 1305

Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr

1310 1315 1320

Tyr Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu

1325 1330 1335

Leu Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val

1340 1345 1350

Arg Ser Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu

1355 1360 1365

Ile Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile

1370 1375 1380

Ile Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly

1385 1390 1395

Gly Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile

1400 1405 1410

Asn Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val

1415 1420 1425

Leu Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser

1430 1435 1440

Val Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln

1445 1450 1455

Lys Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn

1460 1465 1470

Gly Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu

1475 1480 1485

Leu Ser Asp Val Val Leu Ile Ile Lys Val Tyr Met Asp Asn Ser

1490 1495 1500

Lys Pro Pro Phe Gly Tyr Tyr Ser Asn Asp Leu Lys Asp Val Lys

1505 1510 1515

Ala Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu

1520 1525 1530

Lys Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Lys

1535 1540 1545

Asn Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val

1550 1555 1560

Ala Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr

1565 1570 1575

Ser Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser

1580 1585 1590

Ile Phe Ile Lys Ser Leu Lys Ser Asn Ala Lys Leu Ile Leu Asp

1595 1600 1605

Thr Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu

1610 1615 1620

Phe Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys

1625 1630 1635

Phe Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg

1640 1645 1650

Gln Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly

1655 1660 1665

Asp Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr

1670 1675 1680

Gly Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile

1685 1690 1695

Tyr Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn

1700 1705 1710

Thr Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu

1715 1720 1725

Lys Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp

1730 1735 1740

Ser Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu

1745 1750 1755

Asn Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys

1760 1765 1770

Gly Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys

1775 1780 1785

Gln Asp Val Ser Ile Asn Lys Ile Ile Ser Thr Phe Thr Pro Ser

1790 1795 1800

Tyr Tyr Val Glu Gly Leu Leu Asn Tyr His Leu Gly Leu Ile Ser

1805 1810 1815

Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val

1820 1825 1830

Ser Gly Leu Val Tyr Ile Asp Ser Leu Tyr Tyr Phe Lys Pro

1835 1840 1845

Pro Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp

1850 1855 1860

Lys Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly

1865 1870 1875

Glu Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Pro Asn Gly

1880 1885 1890

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr

1895 1900 1905

Phe Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala

1910 1915 1920

Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Val Tyr Tyr

1925 1930 1935

Phe Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp

1940 1945 1950

Asp Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys

1955 1960 1965

Gly Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp

1970 1975 1980

Gly Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe

1985 1990 1995

Tyr Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile

2000 2005 2010

Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile

2015 2020 2025

Gly Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His

2030 2035 2040

Asp Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser

2045 2050 2055

Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser

2060 2065 2070

Phe Thr Ala Val Val Gly Trp Lys Asp Ser Glu Asp Gly Ser Lys

2075 2080 2085

Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser

2090 2095 2100

Thr Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met

2105 2110 2115

Gln Ile Gly Phe Val Thr Ile Asn Glu Val Phe Tyr Phe Ser

2120 2125 2130

Asp Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn

2135 2140 2145

Tyr Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe

2150 2155 2160

Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val

2165 2170 2175

Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val

2180 2185 2190

Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile

2195 2200 2205

Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr

2210 2215 2220

Tyr Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val

2225 2230 2235

Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg

2240 2245 2250

Thr Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu

2255 2260 2265

Asp Gly Ile Met Gln Tyr Gly Tyr Ile Asn Ile Glu Asp Lys Met

2270 2275 2280

Phe Tyr Phe Asn Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn

2285 2290 2295

Thr Ala Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp

2300 2305 2310

Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp

2315 2320 2325

Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala

2330 2335 2340

Ile Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro

2345 2350 2355

Asp Thr Ala Glu Leu Val Ile Ser Glu

2360 2365

<210> 128

<211> 2367

<212> PROTEIN

<213> Clostridium difficile

<400> 128

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met

165 170 175

Gln Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu

260 265 270

Arg Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro

290 295 300

Asp Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala

305 310 315 320

Ile Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe

325 330 335

Asp Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala

340 345 350

Ser Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu

355 360 365

Val Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile

370 375 380

Asn Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu

385 390 395 400

Ile Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly

405 410 415

Pro Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe

420 425 430

Gly Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile

435 440 445

Ala Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn

450 455 460

Thr Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys

465 470 475 480

Asp Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser

485 490 495

Ser Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala

500 505 510

Thr Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala

515 520 525

Lys Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Ile Asp Lys

545 550 555 560

Glu Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg

565 570 575

Gly Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr

580 585 590

Glu Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu

595 600 605

Phe Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro

610 615 620

Thr Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg

625 630 635 640

Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Leu Ile Gly His Gly Lys

645 650 655

Ala Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu

660 665 670

Ser Ser Glu Ile Glu Thr Ile Ile Asp Leu Ala Lys Ala Asp Ile Ser

675 680 685

Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Ser Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val

705 710 715 720

Lys Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile

725 730 735

Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser

755 760 765

Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys

770 775 780

Glu Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr

785 790 795 800

Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu

805 810 815

Glu Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn

820 825 830

Ile Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu

835 840 845

Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu

850 855 860

Ser Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu

865 870 875 880

Glu Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly

885 890 895

Phe Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val

900 905 910

Glu Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu

915 920 925

Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys

930 935 940

Leu Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys

965 970 975

Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val

995 1000 1005

Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu

1010 1015 1020

Pro Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp

1025 1030 1035

Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser

1040 1045 1050

Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met

1055 1060 1065

Ala Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser

1070 1075 1080

Leu Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile

1115 1120 1125

Ser Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys

1130 1135 1140

Ile Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile

1190 1195 1200

Tyr Asp Val Leu Glu Val Lys Lys Glu Glu Leu Asp Leu Ser Lys

1205 1210 1215

Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Gly Trp

1220 1225 1230

Glu Thr Gly Trp Thr Pro Gly Leu Arg Gly Leu Glu Asn Asp Gly

1235 1240 1245

Thr Lys Leu Leu Asp Arg Ile Arg Asp Gln Tyr Glu Gly Gln Phe

1250 1255 1260

Tyr Trp Arg Phe Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr

1265 1270 1275

Leu Lys Pro Arg Tyr Glu Asp Thr Asn Val Arg Ile Ser Leu Asp

1280 1285 1290

Ser Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr

1295 1300 1305

Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr

1310 1315 1320

Tyr Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu

1325 1330 1335

Leu Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val

1340 1345 1350

Arg Ser Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu

1355 1360 1365

Ile Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile

1370 1375 1380

Ile Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly

1385 1390 1395

Gly Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile

1400 1405 1410

Asn Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val

1415 1420 1425

Leu Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser

1430 1435 1440

Val Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln

1445 1450 1455

Lys Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn

1460 1465 1470

Gly Phe Ile Asn Cys Ser Thr Lys Asp Gly Leu Phe Val Ser Glu

1475 1480 1485

Leu Ser Asp Val Val Leu Ile Ile Lys Val Tyr Met Asp Asn Ser

1490 1495 1500

Lys Pro Pro Phe Gly Tyr Tyr Ser Asn Asp Leu Lys Asp Val Lys

1505 1510 1515

Ala Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu

1520 1525 1530

Lys Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Lys

1535 1540 1545

Asn Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val

1550 1555 1560

Ala Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr

1565 1570 1575

Ser Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser

1580 1585 1590

Ile Phe Ile Lys Ser Leu Lys Ser Asn Ala Lys Leu Ile Leu Asp

1595 1600 1605

Thr Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu

1610 1615 1620

Phe Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys

1625 1630 1635

Phe Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg

1640 1645 1650

Gln Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly

1655 1660 1665

Asp Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr

1670 1675 1680

Gly Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile

1685 1690 1695

Tyr Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn

1700 1705 1710

Thr Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu

1715 1720 1725

Lys Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp

1730 1735 1740

Ser Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu

1745 1750 1755

Asn Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys

1760 1765 1770

Gly Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys

1775 1780 1785

Gln Asp Val Ser Ile Asn Lys Ile Ile Ser Thr Phe Thr Pro Ser

1790 1795 1800

Tyr Tyr Val Glu Gly Leu Leu Asn Tyr His Leu Gly Leu Ile Ser

1805 1810 1815

Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val

1820 1825 1830

Ser Gly Leu Val Tyr Ile Asp Ser Leu Tyr Tyr Phe Lys Pro

1835 1840 1845

Pro Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp

1850 1855 1860

Lys Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly

1865 1870 1875

Glu Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Pro Asn Gly

1880 1885 1890

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr

1895 1900 1905

Phe Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala

1910 1915 1920

Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Val Tyr Tyr

1925 1930 1935

Phe Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp

1940 1945 1950

Asp Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys

1955 1960 1965

Gly Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp

1970 1975 1980

Gly Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe

1985 1990 1995

Tyr Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile

2000 2005 2010

Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile

2015 2020 2025

Gly Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His

2030 2035 2040

Asp Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser

2045 2050 2055

Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser

2060 2065 2070

Phe Thr Ala Val Val Gly Trp Lys Asp Ser Glu Asp Gly Ser Lys

2075 2080 2085

Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser

2090 2095 2100

Thr Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met

2105 2110 2115

Gln Ile Gly Phe Val Thr Ile Asn Glu Val Phe Tyr Phe Ser

2120 2125 2130

Asp Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn

2135 2140 2145

Tyr Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe

2150 2155 2160

Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val

2165 2170 2175

Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val

2180 2185 2190

Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile

2195 2200 2205

Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr

2210 2215 2220

Tyr Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val

2225 2230 2235

Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg

2240 2245 2250

Thr Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu

2255 2260 2265

Asp Gly Ile Met Gln Tyr Gly Tyr Ile Asn Ile Glu Asp Lys Met

2270 2275 2280

Phe Tyr Phe Asn Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn

2285 2290 2295

Thr Ala Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp

2300 2305 2310

Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp

2315 2320 2325

Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala

2330 2335 2340

Ile Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro

2345 2350 2355

Asp Thr Ala Glu Leu Val Ile Ser Glu

2360 2365

<210> 129

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 129

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 130

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 130

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 131

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 131

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Leu Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 132

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 132

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 133

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 133

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr

180 185 190

Gln Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser

1115 1120 1125

Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu

1325 1330 1335

Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Ser Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys

1490 1495 1500

Pro Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys

1715 1720 1725

Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly

1760 1765 1770

Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu

1865 1870 1875

Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe

1925 1930 1935

Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp

1940 1945 1950

Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile

2090 2095 2100

Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln

2105 2110 2115

Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp

2255 2260 2265

Gly Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe

2270 2275 2280

Tyr Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 134

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 134

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 135

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 135

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 136

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 136

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asn Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Gly Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 137

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 137

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asn Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Gly Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 138

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 138

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 139

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 139

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 140

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 140

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asn Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 141

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 141

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 142

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 142

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 143

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 143

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 144

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 144

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 145

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 145

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 146

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 146

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 147

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 147

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 148

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 148

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 149

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 149

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 150

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 150

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 151

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 151

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Gly Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 152

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 152

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 153

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 153

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 154

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 154

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 155

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 155

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 156

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 156

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Gly Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 157

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 157

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asn Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 158

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 158

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 159

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 159

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 160

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 160

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 161

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 161

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 162

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 162

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 163

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 163

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 164

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 164

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 165

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 165

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 166

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 166

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 167

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 167

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Ile Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 168

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 168

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 169

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 169

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 170

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 170

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Asp Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 171

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 171

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Asp Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 172

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 172

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Asp Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 173

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 173

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 174

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 174

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Arg Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 175

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 175

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Arg Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 176

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 176

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Arg Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 177

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 177

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Arg Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 178

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 178

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asn Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Gly Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 179

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 179

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Glu Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 180

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 180

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Asp Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 181

<211> 2366

<212> PROTEIN

<213> Clostridium difficile

<400> 181

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys

515 520 525

Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu

915 920 925

Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp

2000 2005 2010

Gly Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Gln Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 182

<211> 2367

<212> PROTEIN

<213> Clostridium difficile

<400> 182

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Ile Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Ile Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met

165 170 175

Gln Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu

260 265 270

Arg Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro

290 295 300

Asp Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala

305 310 315 320

Ile Met Lys His Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe

325 330 335

Asp Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala

340 345 350

Ser Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu

355 360 365

Val Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile

370 375 380

Asn Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu

385 390 395 400

Ile Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly

405 410 415

Pro Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe

420 425 430

Gly Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile

435 440 445

Ala Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn

450 455 460

Thr Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys

465 470 475 480

Asp Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser

485 490 495

Ser Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala

500 505 510

Thr Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala

515 520 525

Lys Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Thr Asp Lys

545 550 555 560

Glu Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg

565 570 575

Gly Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr

580 585 590

Glu Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu

595 600 605

Phe Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro

610 615 620

Thr Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg

625 630 635 640

Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys

645 650 655

Ala Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu

660 665 670

Ser Ser Glu Ile Glu Thr Ala Ile Gly Leu Ala Lys Glu Asp Ile Ser

675 680 685

Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Ser Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val

705 710 715 720

Lys Asp Lys Val Ser Glu Leu Met Pro Ser Met Ser Gln Asp Ser Ile

725 730 735

Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser

755 760 765

Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys

770 775 780

Glu Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr

785 790 795 800

Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu

805 810 815

Glu Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn

820 825 830

Ile Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu

835 840 845

Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu

850 855 860

Ser Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu

865 870 875 880

Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly

885 890 895

Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val

900 905 910

Glu Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu

915 920 925

Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys

930 935 940

Leu Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys

965 970 975

Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val

995 1000 1005

Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu

1010 1015 1020

Pro Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp

1025 1030 1035

Gly Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser

1040 1045 1050

Asp Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met

1055 1060 1065

Ala Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser

1070 1075 1080

Leu Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val

1100 1105 1110

Leu Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val

1115 1120 1125

Ser Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys

1130 1135 1140

Val Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe

1175 1180 1185

Phe Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile

1190 1195 1200

Tyr Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys

1205 1210 1215

Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp

1220 1225 1230

Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe

1250 1255 1260

Tyr Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr

1265 1270 1275

Leu Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp

1280 1285 1290

Ser Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr

1295 1300 1305

Ile Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr

1310 1315 1320

Tyr Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu

1325 1330 1335

Leu Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val

1340 1345 1350

Arg Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu

1355 1360 1365

Ile Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile

1370 1375 1380

Ile Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly

1385 1390 1395

Ser Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile

1400 1405 1410

Asn Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu

1415 1420 1425

Leu Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His

1430 1435 1440

Ile Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln

1445 1450 1455

Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn

1460 1465 1470

Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu

1475 1480 1485

Leu Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser

1490 1495 1500

Lys Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys

1505 1510 1515

Val Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu

1520 1525 1530

Lys Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu

1535 1540 1545

Lys Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val

1550 1555 1560

Ala Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr

1565 1570 1575

Ser Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser

1580 1585 1590

Ile Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp

1595 1600 1605

Ala Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu

1610 1615 1620

Phe Ile Cys Asp Glu Asn Asn Asn Ile Gln Pro Tyr Phe Ile Lys

1625 1630 1635

Phe Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg

1640 1645 1650

Gln Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly

1655 1660 1665

Asp Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr

1670 1675 1680

Gly Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile

1685 1690 1695

Tyr Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn

1700 1705 1710

Thr Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu

1715 1720 1725

Lys Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp

1730 1735 1740

Ser Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu

1745 1750 1755

Asn Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys

1760 1765 1770

Asp Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys

1775 1780 1785

Gln Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser

1790 1795 1800

Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser

1805 1810 1815

Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val

1820 1825 1830

Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro

1835 1840 1845

Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp

1850 1855 1860

Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly

1865 1870 1875

Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

1880 1885 1890

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr

1895 1900 1905

Phe Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala

1910 1915 1920

Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr

1925 1930 1935

Phe Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp

1940 1945 1950

Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys

1955 1960 1965

Gly Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp

1970 1975 1980

Gly Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His

1985 1990 1995

Tyr Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile

2000 2005 2010

Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile

2015 2020 2025

Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His

2030 2035 2040

Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser

2045 2050 2055

Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser

2060 2065 2070

Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys

2075 2080 2085

Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser

2090 2095 2100

Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met

2105 2110 2115

Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

2120 2125 2130

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn

2135 2140 2145

Tyr Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe

2150 2155 2160

Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val

2165 2170 2175

Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val

2180 2185 2190

Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile

2195 2200 2205

Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr

2210 2215 2220

Tyr Phe Asp Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu

2225 2230 2235

Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg

2240 2245 2250

Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu

2255 2260 2265

Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met

2270 2275 2280

Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn

2285 2290 2295

Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp

2300 2305 2310

Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp

2315 2320 2325

Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala

2330 2335 2340

Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro

2345 2350 2355

Asp Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 183

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 183

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Lys Tyr Ser Ser Asn Lys

965 970 975

Lys Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 184

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 184

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Lys Tyr Asn Ser Ser Lys Lys Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 185

<211> 320

<212> PROTEIN

<213> Clostridium difficile

<400> 185

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn

1 5 10 15

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

20 25 30

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

35 40 45

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

50 55 60

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp

65 70 75 80

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly

85 90 95

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser

100 105 110

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe

115 120 125

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

130 135 140

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

145 150 155 160

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile

165 170 175

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile

180 185 190

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn

195 200 205

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu

210 215 220

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala

225 230 235 240

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr

245 250 255

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

260 265 270

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

275 280 285

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

290 295 300

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro

305 310 315 320

<210> 186

<211> 611

<212> PROTEIN

<213> Clostridium difficile

<400> 186

Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys Ile

1 5 10 15

Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu Ser

20 25 30

Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile Leu

35 40 45

Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu

50 55 60

Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly

65 70 75 80

Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe

85 90 95

Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp

100 105 110

Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly

115 120 125

Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

130 135 140

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

145 150 155 160

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe

165 170 175

Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp Asn

180 185 190

Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His Tyr

195 200 205

Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile Gly

210 215 220

Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly Phe

225 230 235 240

Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val Met

245 250 255

Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala Glu

260 265 270

Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe Lys

275 280 285

Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu

290 295 300

Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe

305 310 315 320

Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly

325 330 335

Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu

340 345 350

Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met

355 360 365

Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

370 375 380

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

385 390 395 400

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser

405 410 415

Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile

420 425 430

Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp

435 440 445

Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr

450 455 460

Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys

465 470 475 480

Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe

485 490 495

Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn

500 505 510

Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn

515 520 525

Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile

530 535 540

Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn

545 550 555 560

Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp

565 570 575

Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala

580 585 590

Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro

595 600 605

Asp Thr Ala

610

<210> 187

<211> 965

<212> PROTEIN

<213> Clostridium difficile

<400> 187

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

1 5 10 15

Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr

20 25 30

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn

35 40 45

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

50 55 60

Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys

65 70 75 80

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp Arg Ile

85 90 95

Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala

100 105 110

Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp

115 120 125

Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr

130 135 140

Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly

145 150 155 160

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn

165 170 175

Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn

180 185 190

Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

195 200 205

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

210 215 220

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

225 230 235 240

Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys

245 250 255

Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr

260 265 270

Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln

275 280 285

Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

290 295 300

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn

305 310 315 320

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

325 330 335

Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

340 345 350

Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly

355 360 365

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr

370 375 380

Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met

385 390 395 400

Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro

405 410 415

Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

420 425 430

Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

435 440 445

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

450 455 460

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp

465 470 475 480

Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe

485 490 495

Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala

500 505 510

Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His

515 520 525

Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr

530 535 540

Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr

545 550 555 560

Ala Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr

565 570 575

Phe Phe Gly Val Asp Gly Val Lys Ala Pro Gly Phe Val Ser Ile Asn

580 585 590

Asp Asn Lys His Tyr Phe Asp Ser Gly Val Met Lys Val Gly Tyr

595 600 605

Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met

610 615 620

Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His

625 630 635 640

His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser

645 650 655

Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

660 665 670

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

675 680 685

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile Asn

690 695 700

Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val Gly Phe

705 710 715 720

Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile Ile

725 730 735

Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Asp

740 745 750

Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys

755 760 765

Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala

770 775 780

Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe

785 790 795 800

Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn

805 810 815

Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys

820 825 830

Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly

835 840 845

Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe

850 855 860

Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys

865 870 875 880

Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn

885 890 895

Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

900 905 910

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

915 920 925

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser

930 935 940

Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln

945 950 955 960

Leu Val Ile Ser Glu

965

<210> 188

<211> 965

<212> PROTEIN

<213> Clostridium difficile

<400> 188

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

1 5 10 15

Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr

20 25 30

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn

35 40 45

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

50 55 60

Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys

65 70 75 80

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp Arg Ile

85 90 95

Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala

100 105 110

Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp

115 120 125

Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr

130 135 140

Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly

145 150 155 160

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn

165 170 175

Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn

180 185 190

Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

195 200 205

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

210 215 220

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

225 230 235 240

Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys

245 250 255

Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr

260 265 270

Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln

275 280 285

Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

290 295 300

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn

305 310 315 320

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

325 330 335

Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

340 345 350

Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly

355 360 365

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr

370 375 380

Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met

385 390 395 400

Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro

405 410 415

Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

420 425 430

Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

435 440 445

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

450 455 460

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp

465 470 475 480

Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe

485 490 495

Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala

500 505 510

Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His

515 520 525

Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr

530 535 540

Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr

545 550 555 560

Ala Met Ala Ala Ala Gly Gly Leu Asn Gln Ile Gly Asp Tyr Lys Tyr

565 570 575

Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser Ile Asn

580 585 590

Asp Asn Lys His Tyr Phe Asp Ser Gly Val Met Lys Val Gly Tyr

595 600 605

Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met

610 615 620

Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His

625 630 635 640

His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser

645 650 655

Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

660 665 670

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

675 680 685

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile Asn

690 695 700

Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val Gly Phe

705 710 715 720

Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile Ile

725 730 735

Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Asp

740 745 750

Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys

755 760 765

Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala

770 775 780

Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe

785 790 795 800

Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn

805 810 815

Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys

820 825 830

Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly

835 840 845

Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe

850 855 860

Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys

865 870 875 880

Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn

885 890 895

Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

900 905 910

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

915 920 925

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser

930 935 940

Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln

945 950 955 960

Leu Val Ile Ser Glu

965

<210> 189

<211> 832

<212> PROTEIN

<213> Clostridium difficile

<400> 189

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

1 5 10 15

Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr

20 25 30

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn

35 40 45

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

50 55 60

Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys

65 70 75 80

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp Arg Ile

85 90 95

Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala

100 105 110

Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp

115 120 125

Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr

130 135 140

Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly

145 150 155 160

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn

165 170 175

Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn

180 185 190

Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

195 200 205

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

210 215 220

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

225 230 235 240

Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys

245 250 255

Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr

260 265 270

Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln

275 280 285

Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

290 295 300

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn

305 310 315 320

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

325 330 335

Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

340 345 350

Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly

355 360 365

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr

370 375 380

Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met

385 390 395 400

Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro

405 410 415

Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

420 425 430

Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

435 440 445

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

450 455 460

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp

465 470 475 480

Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe

485 490 495

Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala His His Asn Glu Asp Leu

500 505 510

Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe

515 520 525

Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr Ala Val Val Gly

530 535 540

Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr

545 550 555 560

Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile Asp Gly Gln Tyr Tyr

565 570 575

Phe Asn Asp Asp Gly Ile Met Gln Val Gly Phe Val Thr Ile Asn Asp

580 585 590

Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile Ile Glu Ser Gly Val Gln

595 600 605

Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln

610 615 620

Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala

625 630 635 640

Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly

645 650 655

Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr

660 665 670

Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr

675 680 685

Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

690 695 700

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

705 710 715 720

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu

725 730 735

Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly

740 745 750

Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro Asp Gly Phe

755 760 765

Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu

770 775 780

Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr

785 790 795 800

Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile Asp Gly

805 810 815

Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val Ile Ser Glu

820 825 830

<210> 190

<211> 1056

<212> PROTEIN

<213> Clostridium difficile

<400> 190

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

1 5 10 15

Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr

20 25 30

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn

35 40 45

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

50 55 60

Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys

65 70 75 80

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp Arg Ile

85 90 95

Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala

100 105 110

Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp

115 120 125

Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr

130 135 140

Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly

145 150 155 160

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn

165 170 175

Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn

180 185 190

Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

195 200 205

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

210 215 220

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

225 230 235 240

Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys

245 250 255

Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr

260 265 270

Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln

275 280 285

Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

290 295 300

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn

305 310 315 320

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

325 330 335

Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

340 345 350

Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly

355 360 365

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr

370 375 380

Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met

385 390 395 400

Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro

405 410 415

Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

420 425 430

Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

435 440 445

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

450 455 460

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp

465 470 475 480

Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe

485 490 495

Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala

500 505 510

Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His

515 520 525

Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr

530 535 540

Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr

545 550 555 560

Ala Met Ala Ala Ala Gly Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr

565 570 575

Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr Gly Val Phe Ser Thr Glu

580 585 590

Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu

595 600 605

Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn

610 615 620

Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu

625 630 635 640

Leu Asp Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe

645 650 655

Lys Gly Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp

660 665 670

Gly Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

675 680 685

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

690 695 700

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val Phe

705 710 715 720

Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu Asp Leu

725 730 735

Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe

740 745 750

Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr Ala Val Val Gly

755 760 765

Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr

770 775 780

Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile Asp Gly Gln Tyr Tyr

785 790 795 800

Phe Asn Asp Asp Gly Ile Met Gln Val Gly Phe Val Thr Ile Asn Asp

805 810 815

Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile Ile Glu Ser Gly Val Gln

820 825 830

Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln

835 840 845

Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala

850 855 860

Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly

865 870 875 880

Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr

885 890 895

Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr

900 905 910

Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

915 920 925

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

930 935 940

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu

945 950 955 960

Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly

965 970 975

Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro Asp Gly Phe

980 985 990

Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu

995 1000 1005

Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg Tyr

1010 1015 1020

Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile

1025 1030 1035

Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val

1040 1045 1050

Ile Ser Glu

1055

<210> 191

<211> 970

<212> PROTEIN

<213> Clostridium difficile

<400> 191

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

1 5 10 15

Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr

20 25 30

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn

35 40 45

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

50 55 60

Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys

65 70 75 80

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp Arg Ile

85 90 95

Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala

100 105 110

Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp

115 120 125

Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr

130 135 140

Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly

145 150 155 160

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn

165 170 175

Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn

180 185 190

Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

195 200 205

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

210 215 220

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

225 230 235 240

Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys

245 250 255

Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr

260 265 270

Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln

275 280 285

Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

290 295 300

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn

305 310 315 320

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

325 330 335

Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

340 345 350

Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly

355 360 365

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr

370 375 380

Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met

385 390 395 400

Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro

405 410 415

Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

420 425 430

Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

435 440 445

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

450 455 460

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp

465 470 475 480

Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe

485 490 495

Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala

500 505 510

Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His

515 520 525

Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr

530 535 540

Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr

545 550 555 560

Ala Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr

565 570 575

Phe Phe Gly Val Asp Gly Val Lys Ala Pro Gly Ile Tyr Gly Gly Gly

580 585 590

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

595 600 605

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

610 615 620

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

625 630 635 640

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

645 650 655

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

660 665 670

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

675 680 685

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

690 695 700

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

705 710 715 720

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

725 730 735

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

740 745 750

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

755 760 765

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

770 775 780

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

785 790 795 800

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

805 810 815

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

820 825 830

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

835 840 845

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

850 855 860

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

865 870 875 880

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

885 890 895

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

900 905 910

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

915 920 925

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

930 935 940

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

945 950 955 960

Pro Asp Thr Ala Gln Leu Val Ile Ser Glu

965 970

<210> 192

<211> 1112

<212> PROTEIN

<213> Clostridium difficile

<400> 192

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

1 5 10 15

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His

20 25 30

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly

35 40 45

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn

50 55 60

Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn

65 70 75 80

Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp

85 90 95

Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile

100 105 110

Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser

115 120 125

Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn

130 135 140

Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe

145 150 155 160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn

165 170 175

Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr

180 185 190

Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr

195 200 205

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr

210 215 220

Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

225 230 235 240

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

245 250 255

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly

260 265 270

Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile

275 280 285

Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala

290 295 300

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr

305 310 315 320

Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser

325 330 335

Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr

340 345 350

Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile

355 360 365

Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr

370 375 380

Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly

385 390 395 400

Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe

405 410 415

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

420 425 430

Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly

435 440 445

Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg

450 455 460

Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

465 470 475 480

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

485 490 495

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

500 505 510

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe

515 520 525

Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala

530 535 540

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro

545 550 555 560

Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val

565 570 575

Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro Gly Ile Tyr Gly

580 585 590

Gly Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn Pro

595 600 605

Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp Lys

610 615 620

Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr Gly Val Phe Ser

625 630 635 640

Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp Glu

645 650 655

Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp

660 665 670

Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp

675 680 685

Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys

690 695 700

Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn

705 710 715 720

Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys

725 730 735

His Tyr Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile

740 745 750

Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

755 760 765

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

770 775 780

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile Leu

785 790 795 800

Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr Ala Val

805 810 815

Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr Phe Asp Glu

820 825 830

Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile Asn Asp Gly Gln

835 840 845

Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val Gly Phe Val Thr Ile

850 855 860

Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile Ile Glu Ser Gly

865 870 875 880

Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Asp Asn Gly Ile

885 890 895

Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala

900 905 910

Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr

915 920 925

Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr

930 935 940

Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp

945 950 955 960

Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn

965 970 975

Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg

980 985 990

Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

995 1000 1005

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

1010 1015 1020

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

1025 1030 1035

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

1040 1045 1050

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

1055 1060 1065

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

1070 1075 1080

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

1085 1090 1095

Thr Ala Gln Leu Val Ile Ser Glu His His His His His His His

1100 1105 1110

<210> 193

<211> 1107

<212> PROTEIN

<213> Clostridium difficile

<400> 193

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

1 5 10 15

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His

20 25 30

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly

35 40 45

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn

50 55 60

Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn

65 70 75 80

Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp

85 90 95

Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile

100 105 110

Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser

115 120 125

Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn

130 135 140

Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe

145 150 155 160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn

165 170 175

Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr

180 185 190

Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr

195 200 205

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr

210 215 220

Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

225 230 235 240

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

245 250 255

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly

260 265 270

Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile

275 280 285

Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala

290 295 300

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr

305 310 315 320

Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser

325 330 335

Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr

340 345 350

Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile

355 360 365

Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr

370 375 380

Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly

385 390 395 400

Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe

405 410 415

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

420 425 430

Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly

435 440 445

Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg

450 455 460

Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

465 470 475 480

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

485 490 495

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

500 505 510

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe

515 520 525

Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala

530 535 540

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro

545 550 555 560

Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val

565 570 575

Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Val Thr Gly Phe Val

580 585 590

Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala

595 600 605

Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn

610 615 620

Gln Ser Gly Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe

625 630 635 640

Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu

645 650 655

Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr

660 665 670

Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

675 680 685

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

690 695 700

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met

705 710 715 720

Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp

725 730 735

Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe

740 745 750

Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu

755 760 765

Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu

770 775 780

Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys

785 790 795 800

Ile Tyr Tyr Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp

805 810 815

Leu Glu Asp Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala

820 825 830

Tyr Ile Gly Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp

835 840 845

Asp Gly Ile Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe

850 855 860

Tyr Phe Ser Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp

865 870 875 880

Asp Asn Tyr Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val

885 890 895

Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val

900 905 910

Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

915 920 925

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

930 935 940

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn

945 950 955 960

Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile

965 970 975

Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser

980 985 990

Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe

995 1000 1005

Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp

1010 1015 1020

Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys

1025 1030 1035

Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu

1040 1045 1050

Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg Tyr

1055 1060 1065

Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile

1070 1075 1080

Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val

1085 1090 1095

Ile Ser Glu His His His His His His His

1100 1105

<210> 194

<211> 1128

<212> PROTEIN

<213> Clostridium difficile

<400> 194

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

1 5 10 15

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His

20 25 30

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly

35 40 45

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn

50 55 60

Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn

65 70 75 80

Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp

85 90 95

Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile

100 105 110

Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser

115 120 125

Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn

130 135 140

Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe

145 150 155 160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn

165 170 175

Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr

180 185 190

Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr

195 200 205

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr

210 215 220

Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

225 230 235 240

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

245 250 255

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly

260 265 270

Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile

275 280 285

Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala

290 295 300

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr

305 310 315 320

Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser

325 330 335

Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr

340 345 350

Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile

355 360 365

Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr

370 375 380

Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly

385 390 395 400

Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe

405 410 415

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

420 425 430

Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly

435 440 445

Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg

450 455 460

Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

465 470 475 480

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

485 490 495

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

500 505 510

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe

515 520 525

Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala

530 535 540

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro

545 550 555 560

Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val

565 570 575

Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Val Ser Gly Leu Ile

580 585 590

Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val Asn Asn Leu

595 600 605

Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn Pro

610 615 620

Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp Lys

625 630 635 640

Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr Gly Val Phe Ser

645 650 655

Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp Glu

660 665 670

Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp

675 680 685

Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp

690 695 700

Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys

705 710 715 720

Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn

725 730 735

Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys

740 745 750

His Tyr Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile

755 760 765

Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

770 775 780

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

785 790 795 800

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile Leu

805 810 815

Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr Ala Val

820 825 830

Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr Phe Asp Glu

835 840 845

Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile Asn Asp Gly Gln

850 855 860

Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val Gly Phe Val Thr Ile

865 870 875 880

Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile Ile Glu Ser Gly

885 890 895

Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Asp Asn Gly Ile

900 905 910

Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala

915 920 925

Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr

930 935 940

Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr

945 950 955 960

Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp

965 970 975

Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn

980 985 990

Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg

995 1000 1005

Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu

1010 1015 1020

Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met

1025 1030 1035

Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn

1040 1045 1050

Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp

1055 1060 1065

Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp

1070 1075 1080

Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala

1085 1090 1095

Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro

1100 1105 1110

Asp Thr Ala Gln Leu Val Ile Ser Glu His His His His His His His

1115 1120 1125

<210> 195

<211> 994

<212> PROTEIN

<213> Clostridium difficile

<400> 195

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

1 5 10 15

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His

20 25 30

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly

35 40 45

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn

50 55 60

Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn

65 70 75 80

Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp

85 90 95

Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile

100 105 110

Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser

115 120 125

Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn

130 135 140

Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe

145 150 155 160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn

165 170 175

Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr

180 185 190

Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr

195 200 205

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr

210 215 220

Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

225 230 235 240

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

245 250 255

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly

260 265 270

Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile

275 280 285

Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala

290 295 300

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr

305 310 315 320

Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser

325 330 335

Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr

340 345 350

Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile

355 360 365

Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr

370 375 380

Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly

385 390 395 400

Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe

405 410 415

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

420 425 430

Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly

435 440 445

Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg

450 455 460

Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

465 470 475 480

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

485 490 495

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

500 505 510

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe

515 520 525

Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala

530 535 540

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro

545 550 555 560

Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val

565 570 575

Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Val Lys Gly Leu Asn

580 585 590

Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln

595 600 605

Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser

610 615 620

Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr

625 630 635 640

Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp

645 650 655

Gly Phe Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu

660 665 670

Gly Glu Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile

675 680 685

Tyr Tyr Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu

690 695 700

Glu Asp Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr

705 710 715 720

Ile Gly Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp

725 730 735

Gly Ile Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr

740 745 750

Phe Ser Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp

755 760 765

Asn Tyr Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe

770 775 780

Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

785 790 795 800

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

805 810 815

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly

820 825 830

Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro

835 840 845

Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys

850 855 860

Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe

865 870 875 880

Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly

885 890 895

Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val

900 905 910

Met Gln Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala

915 920 925

His Gln Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr

930 935 940

Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu

945 950 955 960

Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr

965 970 975

Phe Asp Pro Asp Thr Ala Gln Leu Val Ile Ser Glu His His His His

980 985 990

His His

<210> 196

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 196

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Val Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 197

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 197

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 198

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 198

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 199

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 199

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 200

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 200

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 201

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 201

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asp Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Val

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Ser Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 202

<211> 2710

<212> PROTEIN

<213> Clostridium difficile

<400> 202

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Lys Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Glu Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Asp Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Asp Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 203

<211> 2710

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 203

Gly Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Gln Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 204

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 204

Gly Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 205

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 205

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 206

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 206

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 207

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 207

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ala Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 208

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 208

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 209

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 209

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His

2165 2170 2175

Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 210

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 210

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 211

<211> 718

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 211

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu

705 710 715

<210> 212

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<220>

<221> other_characteristic

<222> (100)..(100)

<223> Xaa can be any naturally occurring amino acid

<220>

<221> OPTION

<222> (101)..(101)

<223> Xaa is any amino acid other than Trp

<220>

<221> OPTION

<222> (286)..(286)

<223> Xaa is any amino acid other than Asp

<220>

<221> OPTION

<222> (513)..(513)

<223> Xaa is any amino acid other than Glu

<220>

<221> OPTION

<222> (518)..(518)

<223> Xaa is any amino acid other than Trp

<220>

<221> OPTION

<222> (699)..(699)

<223> Xaa is any amino acid other than Cys

<400> 212

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Xaa Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Xaa Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Xaa Ile Asn Ser Leu Xaa Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Xaa Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 213

<211> 2366

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 213

Gly Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Gln Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 214

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 214

Gly Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 215

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 215

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 216

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 216

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 217

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 217

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ala Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 218

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 218

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 219

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 219

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser Val

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys Asp

705 710 715 720

Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu

1115 1120 1125

Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn

1325 1330 1335

Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Ser

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys Pro

1490 1495 1500

Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys Ile

1715 1720 1725

Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly Asn

1760 1765 1770

Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile

1835 1840 1845

Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr

1865 1870 1875

Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly

1925 1930 1935

Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu

1940 1945 1950

Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile

2090 2095 2100

Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp Gly

2255 2260 2265

Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe Tyr

2270 2275 2280

Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 220

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 220

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Val

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys Asp

705 710 715 720

Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu

1115 1120 1125

Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn

1325 1330 1335

Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Ser

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys Pro

1490 1495 1500

Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys Ile

1715 1720 1725

Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly Asn

1760 1765 1770

Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile

1835 1840 1845

Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr

1865 1870 1875

Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly

1925 1930 1935

Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu

1940 1945 1950

Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile

2090 2095 2100

Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp Gly

2255 2260 2265

Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe Tyr

2270 2275 2280

Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 221

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 221

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 222

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<220>

<221> OPTION

<222> (101)..(101)

<223> Xaa is any amino acid other than Trp

<220>

<221> OPTION

<222> (287)..(287)

<223> Xaa is any amino acid other than Asp

<220>

<221> OPTION

<222> (514)..(514)

<223> Xaa is any amino acid other than Glu

<220>

<221> OPTION

<222> (519)..(519)

<223> Xaa is any amino acid other than Trp

<220>

<221> OPTION

<222> (697)..(697)

<223> Xaa is any amino acid other than Cys

<400> 222

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Xaa Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Xaa Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Xaa Met Ala Ser Leu Xaa Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Xaa Asn Met Phe Ser Tyr Ser Val

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys Asp

705 710 715 720

Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu

1115 1120 1125

Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn

1325 1330 1335

Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Ser

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys Pro

1490 1495 1500

Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys Ile

1715 1720 1725

Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly Asn

1760 1765 1770

Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile

1835 1840 1845

Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr

1865 1870 1875

Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly

1925 1930 1935

Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu

1940 1945 1950

Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile

2090 2095 2100

Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp Gly

2255 2260 2265

Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe Tyr

2270 2275 2280

Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 223

<211> 769

<212> PROTEIN

<213> Clostridium difficile

<400> 223

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala

<210> 224

<211> 541

<212> PROTEIN

<213> Clostridium difficile

<400> 224

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 225

<211> 228

<212> PROTEIN

<213> Clostridium difficile

<400> 225

Leu Ser Glu Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp

1 5 10 15

Lys Asn Tyr Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu

20 25 30

Ala Gly Ser Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp

35 40 45

Asp Ile Ser Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys

50 55 60

Asn Ser Ile Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr

65 70 75 80

Phe Leu Ser Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg

85 90 95

Ile Pro Glu Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile

100 105 110

Gly His Gly Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser

115 120 125

Val Asp Ser Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys

130 135 140

Leu Asp Ile Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn

145 150 155 160

Met Phe Ser Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu

165 170 175

Leu Leu Ser Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn

180 185 190

Lys Asn Ser Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn

195 200 205

Ser Glu Gly Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn

210 215 220

Lys Glu Glu Ala

225

<210> 226

<211> 1039

<212> PROTEIN

<213> Clostridium difficile

<400> 226

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

1 5 10 15

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

20 25 30

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

35 40 45

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

50 55 60

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

65 70 75 80

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

85 90 95

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

100 105 110

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

115 120 125

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

130 135 140

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

145 150 155 160

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

165 170 175

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

180 185 190

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

195 200 205

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

210 215 220

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

225 230 235 240

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu Pro

245 250 255

Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly Ile

260 265 270

Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro Leu

275 280 285

Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn Met

290 295 300

Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly Ala

305 310 315 320

Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile

325 330 335

Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr Ser

340 345 350

Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys Tyr Gly Pro

355 360 365

Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val

370 375 380

Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys

385 390 395 400

Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn

405 410 415

Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser

420 425 430

Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe

435 440 445

Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

450 455 460

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

465 470 475 480

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr

485 490 495

Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro

500 505 510

Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg

515 520 525

Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu

530 535 540

Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser

545 550 555 560

Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp

565 570 575

Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn Gly

580 585 590

Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile Asp

595 600 605

Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser

610 615 620

Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu

625 630 635 640

Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser

645 650 655

Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu

660 665 670

Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn

675 680 685

Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

690 695 700

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

705 710 715 720

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser

725 730 735

Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile

740 745 750

Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser

755 760 765

Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn

770 775 780

Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val

785 790 795 800

Lys Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe

805 810 815

Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn

820 825 830

Phe Val Ile Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly

835 840 845

Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe

850 855 860

Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn

865 870 875 880

Gly Arg Asn Val Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu

885 890 895

Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile

900 905 910

Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser

915 920 925

Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

930 935 940

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

945 950 955 960

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp

965 970 975

Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln

980 985 990

Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe Asn Lys

995 1000 1005

Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser Leu Gly Tyr

1010 1015 1020

Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn Glu Leu Asp

1025 1030 1035

Arg

<210> 227

<211> 266

<212> PROTEIN

<213> Clostridium difficile

<400> 227

Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile Asn Thr Ile Thr

1 5 10 15

Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser

20 25 30

Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn Gly Leu Tyr Leu

35 40 45

Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp

50 55 60

Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile

65 70 75 80

Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp

85 90 95

Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe

100 105 110

Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys

115 120 125

Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

130 135 140

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

145 150 155 160

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr Ile

165 170 175

Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile Asn Ile

180 185 190

Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile Ile Val Leu

195 200 205

Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn Leu Asp Ser Ser

210 215 220

Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp Phe Ile Leu Val

225 230 235 240

Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln Lys Ile Arg Ile

245 250 255

Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe

260 265

<210> 228

<211> 902

<212> PROTEIN

<213> Clostridium difficile

<400> 228

Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys Thr Tyr Tyr Tyr Asp

1 5 10 15

Glu Asp Ser Lys Leu Val Lys Gly Leu Ile Asn Ile Asn Asn Ser Leu

20 25 30

Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp Gln Thr

35 40 45

Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Leu

50 55 60

Ile Ser Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asp

65 70 75 80

Gly Val Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr

85 90 95

Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile

100 105 110

Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe

115 120 125

Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu

130 135 140

Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

145 150 155 160

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

165 170 175

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr

180 185 190

Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His

195 200 205

Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr

210 215 220

Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn

225 230 235 240

Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn

245 250 255

Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp

260 265 270

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

275 280 285

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

290 295 300

Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys

305 310 315 320

Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr

325 330 335

Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln

340 345 350

Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

355 360 365

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn

370 375 380

Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

385 390 395 400

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

405 410 415

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn

420 425 430

Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile

435 440 445

Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys

450 455 460

Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala

465 470 475 480

Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr

485 490 495

Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

500 505 510

Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr

515 520 525

Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

530 535 540

Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr

545 550 555 560

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

565 570 575

Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr

580 585 590

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn

595 600 605

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

610 615 620

Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

625 630 635 640

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

645 650 655

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val

660 665 670

Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn

675 680 685

Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe

690 695 700

Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro

705 710 715 720

Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile

725 730 735

Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp

740 745 750

Asn Ile Tyr Tyr Phe Gly Asn Ser Lys Ala Ala Thr Gly Trp Val

755 760 765

Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly

770 775 780

Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn

785 790 795 800

Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr

805 810 815

Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile

820 825 830

Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe

835 840 845

Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys

850 855 860

Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

865 870 875 880

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

885 890 895

Ala Pro Gly Ile Tyr Gly

900

<210> 229

<211> 204

<212> PROTEIN

<213> Clostridium difficile

<400> 229

Arg Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys

1 5 10 15

Thr Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys

20 25 30

Ile Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

35 40 45

Asn Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

50 55 60

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

65 70 75 80

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe

85 90 95

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly

100 105 110

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp

115 120 125

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile

130 135 140

Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn

145 150 155 160

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

165 170 175

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

180 185 190

Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn

195 200

<210> 230

<211> 457

<212> PROTEIN

<213> Clostridium difficile

<400> 230

Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe

1 5 10 15

Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro

20 25 30

Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile

35 40 45

Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

50 55 60

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

65 70 75 80

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala

85 90 95

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu

100 105 110

Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys

115 120 125

Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser

130 135 140

Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile

145 150 155 160

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

165 170 175

Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

180 185 190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

195 200 205

Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

210 215 220

Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys

225 230 235 240

Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr

245 250 255

Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln

260 265 270

Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

275 280 285

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

290 295 300

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

305 310 315 320

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe

325 330 335

Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn

340 345 350

Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys

355 360 365

Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn

370 375 380

Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu

385 390 395 400

Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly

405 410 415

Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala

420 425 430

Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe

435 440 445

Phe Gly Val Asp Gly Val Lys Ala Pro

450 455

<210> 231

<211> 320

<212> PROTEIN

<213> Clostridium difficile

<400> 231

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn

1 5 10 15

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

20 25 30

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

35 40 45

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

50 55 60

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp

65 70 75 80

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly

85 90 95

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser

100 105 110

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe

115 120 125

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

130 135 140

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

145 150 155 160

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile

165 170 175

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile

180 185 190

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn

195 200 205

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu

210 215 220

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala

225 230 235 240

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr

245 250 255

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

260 265 270

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

275 280 285

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

290 295 300

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro

305 310 315 320

<210> 232

<211> 864

<212> PROTEIN

<213> Clostridium difficile

<400> 232

Phe Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp Gln Thr Ile Asn

1 5 10 15

Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser

20 25 30

Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val

35 40 45

Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala

50 55 60

Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr

65 70 75 80

Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

85 90 95

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

100 105 110

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile

115 120 125

Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser Lys

130 135 140

Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr Asp Thr

145 150 155 160

Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His Phe Tyr

165 170 175

Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr Ser Asn

180 185 190

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu

195 200 205

Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys

210 215 220

Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr

225 230 235 240

Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

245 250 255

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn

260 265 270

Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr

275 280 285

Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile

290 295 300

Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

305 310 315 320

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

325 330 335

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

340 345 350

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala

355 360 365

Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro

370 375 380

Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys

385 390 395 400

Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile

405 410 415

Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val

420 425 430

Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

435 440 445

Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn

450 455 460

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser

465 470 475 480

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

485 490 495

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly

500 505 510

Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp

515 520 525

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile

530 535 540

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn

545 550 555 560

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

565 570 575

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

580 585 590

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

595 600 605

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp

610 615 620

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly

625 630 635 640

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser

645 650 655

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe

660 665 670

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

675 680 685

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

690 695 700

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile

705 710 715 720

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile

725 730 735

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn

740 745 750

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu

755 760 765

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala

770 775 780

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr

785 790 795 800

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

805 810 815

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

820 825 830

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

835 840 845

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro

850 855 860

<210> 233

<211> 403

<212> PROTEIN

<213> Clostridium difficile

<400> 233

Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp

1 5 10 15

Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys

20 25 30

Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

35 40 45

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala

50 55 60

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn

65 70 75 80

Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe

85 90 95

Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro

100 105 110

Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile

115 120 125

Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

130 135 140

Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

145 150 155 160

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

165 170 175

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr

180 185 190

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His

195 200 205

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly

210 215 220

Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn

225 230 235 240

Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His

245 250 255

Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp

260 265 270

Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met

275 280 285

Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg

290 295 300

Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu

305 310 315 320

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala

325 330 335

Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr

340 345 350

Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly

355 360 365

Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly

370 375 380

Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

385 390 395 400

Lys Ala Pro

<210> 234

<211> 872

<212> PROTEIN

<213> Clostridium difficile

<400> 234

Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp

1 5 10 15

Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala

20 25 30

Ala Leu Ile Ser Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn

35 40 45

Asn Asp Gly Val Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe

50 55 60

Glu Tyr Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln

65 70 75 80

Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

85 90 95

Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn

100 105 110

Asn Glu Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly

115 120 125

Leu Gln Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala

130 135 140

Ile Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

145 150 155 160

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

165 170 175

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe

180 185 190

Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn

195 200 205

Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr

210 215 220

Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr

225 230 235 240

Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

245 250 255

Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

260 265 270

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

275 280 285

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly

290 295 300

Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile

305 310 315 320

Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala

325 330 335

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr

340 345 350

Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser

355 360 365

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr

370 375 380

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

385 390 395 400

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

405 410 415

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu

420 425 430

Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr

435 440 445

Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile

450 455 460

Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe

465 470 475 480

Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys

485 490 495

Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln

500 505 510

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala

515 520 525

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

530 535 540

Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His

545 550 555 560

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly

565 570 575

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn

580 585 590

Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn

595 600 605

Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu

610 615 620

Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

625 630 635 640

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

645 650 655

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys

660 665 670

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys

675 680 685

Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn

690 695 700

Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu

705 710 715 720

His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly

725 730 735

Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala

740 745 750

Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe

755 760 765

Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe

770 775 780

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

785 790 795 800

Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr

805 810 815

Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn

820 825 830

Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly

835 840 845

Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly

850 855 860

Val Lys Ala Pro Gly Ile Tyr Gly

865 870

<210> 235

<211> 743

<212> PROTEIN

<213> Clostridium difficile

<400> 235

Ala Val Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro

1 5 10 15

Asp Thr Ala Ile Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg

20 25 30

Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr

35 40 45

Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile

50 55 60

Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

65 70 75 80

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

85 90 95

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys

100 105 110

Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn

115 120 125

Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys

130 135 140

Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln

145 150 155 160

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile Ala

165 170 175

Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

180 185 190

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

195 200 205

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala

210 215 220

Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr

225 230 235 240

Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn

245 250 255

Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu

260 265 270

Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu

275 280 285

Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala

290 295 300

Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

305 310 315 320

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

325 330 335

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

340 345 350

Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile

355 360 365

Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr

370 375 380

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr

385 390 395 400

Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

405 410 415

Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn

420 425 430

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

435 440 445

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His

450 455 460

Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu

465 470 475 480

Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val

485 490 495

Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn

500 505 510

Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr

515 520 525

Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile

530 535 540

Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

545 550 555 560

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

565 570 575

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe

580 585 590

Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala

595 600 605

Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro

610 615 620

Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn

625 630 635 640

Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser

645 650 655

Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile

660 665 670

Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly

675 680 685

Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln

690 695 700

Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala

705 710 715 720

Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly

725 730 735

Val Asp Gly Val Lys Ala Pro

740

<210> 236

<211> 816

<212> PROTEIN

<213> Clostridium difficile

<400> 236

Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala

1 5 10 15

Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr

20 25 30

Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

35 40 45

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

50 55 60

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile

65 70 75 80

Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser Lys

85 90 95

Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr Asp Thr

100 105 110

Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His Phe Tyr

115 120 125

Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr Ser Asn

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys

165 170 175

Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr

180 185 190

Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

195 200 205

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn

210 215 220

Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr

225 230 235 240

Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile

245 250 255

Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

260 265 270

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

275 280 285

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

290 295 300

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala

305 310 315 320

Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro

325 330 335

Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys

340 345 350

Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile

355 360 365

Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val

370 375 380

Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

385 390 395 400

Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn

405 410 415

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser

420 425 430

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

435 440 445

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly

450 455 460

Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp

465 470 475 480

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile

485 490 495

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn

500 505 510

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

515 520 525

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

530 535 540

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

545 550 555 560

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp

565 570 575

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly

580 585 590

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser

595 600 605

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe

610 615 620

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

625 630 635 640

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

645 650 655

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile

660 665 670

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile

675 680 685

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn

690 695 700

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu

705 710 715 720

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala

725 730 735

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr

740 745 750

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

755 760 765

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

770 775 780

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

785 790 795 800

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro

805 810 815

<210> 237

<211> 767

<212> PROTEIN

<213> Clostridium difficile

<400> 237

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly

565 570 575

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly

610 615 620

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser

660 665 670

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser

690 695 700

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys

705 710 715 720

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser

755 760 765

<210> 238

<211> 543

<212> PROTEIN

<213> Clostridium difficile

<400> 238

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg

1 5 10 15

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu

20 25 30

Glu Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys

35 40 45

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys

50 55 60

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val

65 70 75 80

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys

85 90 95

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile

100 105 110

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn

115 120 125

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr

130 135 140

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn

145 150 155 160

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met

165 170 175

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala

180 185 190

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr

195 200 205

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr

210 215 220

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val

225 230 235 240

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu

245 250 255

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu

260 265 270

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp

275 280 285

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro

290 295 300

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp

325 330 335

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn

370 375 380

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val

385 390 395 400

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro

405 410 415

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile

420 425 430

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met

435 440 445

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr

450 455 460

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp

465 470 475 480

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala

485 490 495

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr

500 505 510

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys

515 520 525

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 239

<211> 224

<212> PROTEIN

<213> Clostridium difficile

<400> 239

Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys

1 5 10 15

Glu Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg

20 25 30

Gly Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr

35 40 45

Glu Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu

50 55 60

Phe Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro

65 70 75 80

Gly Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile

85 90 95

Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys

100 105 110

Asp Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu

115 120 125

Ser Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser

130 135 140

Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

145 150 155 160

Ser Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val

165 170 175

Lys Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile

180 185 190

Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

195 200 205

Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser

210 215 220

<210> 240

<211> 1066

<212> PROTEIN

<213> Clostridium difficile

<400> 240

Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys

1 5 10 15

Glu Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr

20 25 30

Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu

35 40 45

Glu Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn

50 55 60

Ile Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu

65 70 75 80

Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu

85 90 95

Ser Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu

100 105 110

Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly

115 120 125

Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val

130 135 140

Glu Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu

145 150 155 160

Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys

165 170 175

Leu Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu

180 185 190

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys

195 200 205

Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala

210 215 220

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val

225 230 235 240

Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

245 250 255

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

260 265 270

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro Leu

275 280 285

Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val Asn Leu

290 295 300

Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly Ile Ala Ser

305 310 315 320

Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile Ser Ala Gly Ile

325 330 335

Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg Asp Lys Ala Thr Lys

340 345 350

Val Val Asp Tyr Phe Lys His Val Ser Leu Val Glu Thr Glu Gly Val

355 360 365

Phe Thr Leu Leu Asp Asp Lys Ile Met Met Pro Gln Asp Asp Leu Val

370 375 380

Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val Leu Gly Lys Cys

385 390 395 400

Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp

405 410 415

Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His

420 425 430

Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu

435 440 445

Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala

450 455 460

Trp Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

465 470 475 480

Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

485 490 495

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

500 505 510

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn Thr

515 520 525

Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg Glu Lys

530 535 540

Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala Leu Ser Leu

545 550 555 560

Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser Glu Ser Asp Val

565 570 575

Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp Val Thr Ile Glu Ser

580 585 590

Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu Gly Ile Leu Ser Thr Leu

595 600 605

Ser Ile Glu Glu Asn Lys Ile Ile Leu Asn Ser His Glu Ile Asn Phe

610 615 620

Ser Gly Glu Val Asn Gly Ser Asn Gly Phe Val Ser Leu Thr Phe Ser

625 630 635 640

Ile Leu Glu Gly Ile Asn Ala Ile Ile Glu Val Asp Leu Leu Ser Lys

645 650 655

Ser Tyr Lys Leu Leu Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn

660 665 670

Ser Asn His Ile Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu

675 680 685

Leu Gln Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu

690 695 700

Asn Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu

705 710 715 720

Leu Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

725 730 735

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

740 745 750

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp Asp

755 760 765

Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr Ile Lys

770 775 780

Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu Ile Leu Lys

785 790 795 800

Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp Ser Leu Met Ser

805 810 815

Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe Val Asn Phe Leu Gln

820 825 830

Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn Phe Ile Ile Ser Gly Thr

835 840 845

Thr Ser Ile Gly Gln Phe Glu Phe Ile Cys Asp Glu Asn Asp Asn Ile

850 855 860

Gln Pro Tyr Phe Ile Lys Phe Asn Thr Leu Glu Thr Asn Tyr Thr Leu

865 870 875 880

Tyr Val Gly Asn Arg Gln Asn Met Ile Val Glu Pro Asn Tyr Asp Leu

885 890 895

Asp Asp Ser Gly Asp Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys

900 905 910

Tyr Leu Tyr Gly Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro

915 920 925

Asn Ile Tyr Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn

930 935 940

Asn Thr Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu

945 950 955 960

Lys Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

965 970 975

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

980 985 990

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr

995 1000 1005

Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp Val

1010 1015 1020

Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr Glu

1025 1030 1035

Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr Asn

1040 1045 1050

Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1055 1060 1065

<210> 241

<211> 514

<212> PROTEIN

<213> Clostridium difficile

<400> 241

Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn Pro

1 5 10 15

Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp Lys

20 25 30

Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr Gly Val Phe Ser

35 40 45

Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp Glu

50 55 60

Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp

65 70 75 80

Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp

85 90 95

Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys

100 105 110

Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn

115 120 125

Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys

130 135 140

His Tyr Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile

145 150 155 160

Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

165 170 175

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

180 185 190

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile Leu

195 200 205

Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr Ala Val

210 215 220

Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr Phe Asp Glu

225 230 235 240

Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile Asn Asp Gly Gln

245 250 255

Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val Gly Phe Val Thr Ile

260 265 270

Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile Ile Glu Ser Gly

275 280 285

Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Asp Asn Gly Ile

290 295 300

Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala

305 310 315 320

Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr

325 330 335

Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr

340 345 350

Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp

355 360 365

Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn

370 375 380

Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg

385 390 395 400

Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

405 410 415

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

420 425 430

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro Asp

435 440 445

Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe Glu

450 455 460

Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg

465 470 475 480

Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile

485 490 495

Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val Ile

500 505 510

SerGlu

<210> 242

<211> 210

<212> PROTEIN

<213> Clostridium difficile

<400> 242

Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala

1 5 10 15

Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr

20 25 30

Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr

35 40 45

Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp

50 55 60

Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn

65 70 75 80

Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg

85 90 95

Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

100 105 110

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

115 120 125

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro Asp

130 135 140

Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe Glu

145 150 155 160

Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg

165 170 175

Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile

180 185 190

Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val Ile

195 200 205

SerGlu

210

<210> 243

<211> 311

<212> PROTEIN

<213> Clostridium difficile

<400> 243

Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp

1 5 10 15

Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys

20 25 30

Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

35 40 45

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

50 55 60

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly

65 70 75 80

Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile

85 90 95

Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly

100 105 110

Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly

115 120 125

Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr

130 135 140

Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met

145 150 155 160

Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala

165 170 175

Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu

180 185 190

Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr

195 200 205

Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu

210 215 220

Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val

225 230 235 240

Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu

245 250 255

Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp

260 265 270

Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

275 280 285

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

290 295 300

Ala Gln Leu Val Ile Ser Glu

305 310

<210> 244

<211> 768

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 244

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

<210> 245

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 245

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 246

<211> 766

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 246

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asn Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly Ala Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser

755 760 765

<210> 247

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 247

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 248

<211> 228

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 248

Leu Ser Glu Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp

1 5 10 15

Lys Asn Tyr Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu

20 25 30

Ala Gly Ser Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asn

35 40 45

Asp Ile Ser Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys

50 55 60

Asn Ser Ile Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr

65 70 75 80

Phe Leu Ser Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg

85 90 95

Ile Pro Glu Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile

100 105 110

Gly Ala Gly Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser

115 120 125

Val Asp Ser Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys

130 135 140

Leu Asp Ile Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn

145 150 155 160

Met Phe Ser Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu

165 170 175

Leu Leu Ser Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn

180 185 190

Lys Asn Ser Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn

195 200 205

Ser Glu Gly Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn

210 215 220

Lys Glu Glu Ala

225

<210> 249

<211> 224

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 249

Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys

1 5 10 15

Glu Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg

20 25 30

Gly Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asn Lys Ile Ser Tyr

35 40 45

Glu Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu

50 55 60

Phe Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro

65 70 75 80

Gly Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile

85 90 95

Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly Ala Gly Lys

100 105 110

Asp Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu

115 120 125

Ser Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser

130 135 140

Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

145 150 155 160

Ser Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val

165 170 175

Lys Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile

180 185 190

Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

195 200 205

Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser

210 215 220

<210> 250

<211> 322

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 250

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn

1 5 10 15

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

20 25 30

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

35 40 45

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

50 55 60

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp

65 70 75 80

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly

85 90 95

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser

100 105 110

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe

115 120 125

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

130 135 140

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

145 150 155 160

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile

165 170 175

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile

180 185 190

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn

195 200 205

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu

210 215 220

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala

225 230 235 240

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr

245 250 255

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

260 265 270

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

275 280 285

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

290 295 300

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro

305 310 315 320

Leu Glu

<210> 251

<211> 320

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 251

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn

1 5 10 15

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

20 25 30

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Asn Asn Asn Ile Glu Gly Gln

35 40 45

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

50 55 60

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp

65 70 75 80

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly

85 90 95

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser

100 105 110

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe

115 120 125

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

130 135 140

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

145 150 155 160

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile

165 170 175

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile

180 185 190

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn

195 200 205

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu

210 215 220

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala

225 230 235 240

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr

245 250 255

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

260 265 270

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

275 280 285

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

290 295 300

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro

305 310 315 320

<210> 252

<211> 320

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 252

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn

1 5 10 15

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

20 25 30

Glu Tyr Phe Ala Pro Ala Asn Thr His Ala Asn Asn Ile Glu Gly Gln

35 40 45

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

50 55 60

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp

65 70 75 80

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly

85 90 95

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser

100 105 110

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe

115 120 125

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

130 135 140

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

145 150 155 160

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile

165 170 175

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile

180 185 190

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn

195 200 205

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu

210 215 220

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala

225 230 235 240

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr

245 250 255

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

260 265 270

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

275 280 285

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

290 295 300

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro

305 310 315 320

<210> 253

<211> 320

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 253

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn

1 5 10 15

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

20 25 30

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

35 40 45

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

50 55 60

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp

65 70 75 80

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly

85 90 95

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser

100 105 110

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe

115 120 125

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

130 135 140

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

145 150 155 160

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile

165 170 175

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile

180 185 190

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn

195 200 205

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu

210 215 220

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala

225 230 235 240

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr

245 250 255

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

260 265 270

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

275 280 285

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

290 295 300

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro

305 310 315 320

<210> 254

<211> 872

<212> PROTEIN

<213> Clostridium difficile

<400> 254

His Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val

1 5 10 15

Arg Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu

20 25 30

Glu Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu

35 40 45

Lys Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr

50 55 60

Lys Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu

65 70 75 80

Val Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu

85 90 95

Lys Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala

100 105 110

Ile Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val

115 120 125

Asn Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys

130 135 140

Thr Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu

145 150 155 160

Asn Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg

165 170 175

Met Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys

180 185 190

Ala Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys

195 200 205

Thr Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr

210 215 220

Tyr Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp

225 230 235 240

Val Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr

245 250 255

Glu Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile

260 265 270

Leu Ala Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val

275 280 285

Ala Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys

290 295 300

Pro Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala

305 310 315 320

Ile Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe

325 330 335

Asp Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala

340 345 350

Ser Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu

355 360 365

Ala Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile

370 375 380

Asn Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile

385 390 395 400

Val Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn

405 410 415

Pro Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe

420 425 430

Ile Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met

435 440 445

Met Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys

450 455 460

Thr Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln

465 470 475 480

Asp Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu

485 490 495

Ala Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser

500 505 510

Thr Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala

515 520 525

Lys Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

Gly Ser Gly Gly Gly Gly Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly

545 550 555 560

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

565 570 575

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn

580 585 590

Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr

595 600 605

Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr

610 615 620

Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

625 630 635 640

Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

645 650 655

Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

660 665 670

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

675 680 685

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

690 695 700

Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu

705 710 715 720

Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala

725 730 735

Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn

740 745 750

Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe

755 760 765

Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn

770 775 780

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

785 790 795 800

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys

805 810 815

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr

820 825 830

Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala

835 840 845

Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val

850 855 860

Asp Gly Val Lys Ala Pro Leu Glu

865 870

<210> 255

<211> 206

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 255

Arg Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys

1 5 10 15

Thr Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys

20 25 30

Ile Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

35 40 45

Asn Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

50 55 60

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

65 70 75 80

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe

85 90 95

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly

100 105 110

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp

115 120 125

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile

130 135 140

Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn

145 150 155 160

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

165 170 175

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

180 185 190

Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Leu Glu

195 200 205

<210> 256

<211> 865

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 256

Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly

1 5 10 15

Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr

20 25 30

Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met

35 40 45

Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro

50 55 60

Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

65 70 75 80

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

85 90 95

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr Tyr

100 105 110

Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile Asp

115 120 125

Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser Lys Gly

130 135 140

Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr Asp Thr Ala

145 150 155 160

Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His Phe Tyr Phe

165 170 175

Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr Ser Asn Gly

180 185 190

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly

195 200 205

Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys

210 215 220

Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile

225 230 235 240

Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr

245 250 255

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

260 265 270

Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

275 280 285

Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

290 295 300

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

305 310 315 320

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

325 330 335

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu

340 345 350

Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val

355 360 365

Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro Asn

370 375 380

Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys Tyr

385 390 395 400

Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu

405 410 415

Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr

420 425 430

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

435 440 445

Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys

450 455 460

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys

465 470 475 480

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

485 490 495

Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys

500 505 510

Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln

515 520 525

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala

530 535 540

Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

545 550 555 560

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

565 570 575

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala

580 585 590

Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr

595 600 605

Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly

610 615 620

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp

625 630 635 640

Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile

645 650 655

Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn

660 665 670

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

675 680 685

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

690 695 700

Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr

705 710 715 720

Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp

725 730 735

Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly

740 745 750

Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro

755 760 765

Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro

770 775 780

Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

785 790 795 800

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

805 810 815

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr

820 825 830

Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu Ile

835 840 845

Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro Leu

850 855 860

Glu

865

<210> 257

<211> 459

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 257

Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe

1 5 10 15

Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro

20 25 30

Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile

35 40 45

Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

50 55 60

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

65 70 75 80

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala

85 90 95

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu

100 105 110

Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys

115 120 125

Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser

130 135 140

Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile

145 150 155 160

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

165 170 175

Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

180 185 190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

195 200 205

Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

210 215 220

Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys

225 230 235 240

Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr

245 250 255

Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln

260 265 270

Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

275 280 285

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

290 295 300

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

305 310 315 320

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe

325 330 335

Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn

340 345 350

Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys

355 360 365

Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn

370 375 380

Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu

385 390 395 400

Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly

405 410 415

Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala

420 425 430

Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe

435 440 445

Phe Gly Val Asp Gly Val Lys Ala Pro Leu Glu

450 455

<210> 258

<211> 888

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 258

Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly

1 5 10 15

Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp

20 25 30

Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala

35 40 45

Ala Leu Ile Ser Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn

50 55 60

Asn Asp Gly Val Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe

65 70 75 80

Glu Tyr Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln

85 90 95

Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

100 105 110

Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn

115 120 125

Asn Glu Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly

130 135 140

Leu Gln Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala

145 150 155 160

Ile Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

165 170 175

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

180 185 190

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe

195 200 205

Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn

210 215 220

Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr

225 230 235 240

Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr

245 250 255

Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

260 265 270

Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

275 280 285

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

290 295 300

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly

305 310 315 320

Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile

325 330 335

Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala

340 345 350

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr

355 360 365

Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser

370 375 380

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr

385 390 395 400

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

405 410 415

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

420 425 430

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu

435 440 445

Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr

450 455 460

Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile

465 470 475 480

Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe

485 490 495

Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys

500 505 510

Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln

515 520 525

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala

530 535 540

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

545 550 555 560

Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His

565 570 575

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly

580 585 590

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn

595 600 605

Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn

610 615 620

Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu

625 630 635 640

Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

645 650 655

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

660 665 670

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys

675 680 685

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys

690 695 700

Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn

705 710 715 720

Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu

725 730 735

His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly

740 745 750

Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala

755 760 765

Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe

770 775 780

Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe

785 790 795 800

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

805 810 815

Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr

820 825 830

Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn

835 840 845

Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly

850 855 860

Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly

865 870 875 880

Val Lys Ala Pro Gly Ile Tyr Gly

885

<210> 259

<211> 832

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 259

Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly

1 5 10 15

Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala

20 25 30

Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr

35 40 45

Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

50 55 60

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

65 70 75 80

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile

85 90 95

Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser Lys

100 105 110

Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr Asp Thr

115 120 125

Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His Phe Tyr

130 135 140

Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr Ser Asn

145 150 155 160

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu

165 170 175

Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys

180 185 190

Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr

195 200 205

Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

210 215 220

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn

225 230 235 240

Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr

245 250 255

Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile

260 265 270

Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

275 280 285

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

290 295 300

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

305 310 315 320

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala

325 330 335

Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro

340 345 350

Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys

355 360 365

Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile

370 375 380

Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val

385 390 395 400

Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

405 410 415

Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn

420 425 430

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser

435 440 445

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

450 455 460

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly

465 470 475 480

Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp

485 490 495

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile

500 505 510

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn

515 520 525

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

530 535 540

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

545 550 555 560

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

565 570 575

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp

580 585 590

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly

595 600 605

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser

610 615 620

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe

625 630 635 640

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

645 650 655

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

660 665 670

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile

675 680 685

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile

690 695 700

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn

705 710 715 720

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu

725 730 735

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala

740 745 750

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr

755 760 765

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

770 775 780

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

785 790 795 800

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

805 810 815

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro

820 825 830

<210> 260

<211> 759

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 260

Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly

1 5 10 15

Ala Val Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro

20 25 30

Asp Thr Ala Ile Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg

35 40 45

Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr

50 55 60

Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile

65 70 75 80

Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

85 90 95

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

100 105 110

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys

115 120 125

Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn

130 135 140

Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys

145 150 155 160

Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln

165 170 175

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile Ala

180 185 190

Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

195 200 205

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

210 215 220

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala

225 230 235 240

Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr

245 250 255

Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn

260 265 270

Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu

275 280 285

Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu

290 295 300

Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala

305 310 315 320

Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

325 330 335

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

340 345 350

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

355 360 365

Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile

370 375 380

Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr

385 390 395 400

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr

405 410 415

Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

420 425 430

Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn

435 440 445

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

450 455 460

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His

465 470 475 480

Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu

485 490 495

Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val

500 505 510

Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn

515 520 525

Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr

530 535 540

Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile

545 550 555 560

Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

565 570 575

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

580 585 590

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe

595 600 605

Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala

610 615 620

Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro

625 630 635 640

Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn

645 650 655

Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser

660 665 670

Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile

675 680 685

Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly

690 695 700

Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln

705 710 715 720

Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala

725 730 735

Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly

740 745 750

Val Asp Gly Val Lys Ala Pro

755

<210> 261

<211> 419

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 261

Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly

1 5 10 15

Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp

20 25 30

Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys

35 40 45

Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

50 55 60

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala

65 70 75 80

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn

85 90 95

Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe

100 105 110

Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro

115 120 125

Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile

130 135 140

Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

145 150 155 160

Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

165 170 175

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

180 185 190

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr

195 200 205

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His

210 215 220

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly

225 230 235 240

Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn

245 250 255

Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His

260 265 270

Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp

275 280 285

Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met

290 295 300

Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg

305 310 315 320

Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu

325 330 335

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala

340 345 350

Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr

355 360 365

Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly

370 375 380

Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly

385 390 395 400

Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

405 410 415

Lys Ala Pro

<210> 262

<211> 244

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 262

Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly

1 5 10 15

Leu Ser Glu Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp

20 25 30

Lys Asn Tyr Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu

35 40 45

Ala Gly Ser Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asn

50 55 60

Asp Ile Ser Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys

65 70 75 80

Asn Ser Ile Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr

85 90 95

Phe Leu Ser Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg

100 105 110

Ile Pro Glu Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile

115 120 125

Gly Ala Gly Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser

130 135 140

Val Asp Ser Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys

145 150 155 160

Leu Asp Ile Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn

165 170 175

Met Phe Ser Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu

180 185 190

Leu Leu Ser Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn

195 200 205

Lys Asn Ser Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn

210 215 220

Ser Glu Gly Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn

225 230 235 240

Lys Glu Glu Ala

<210> 263

<211> 281

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 263

Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly

1 5 10 15

Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile Asn Thr Ile Thr Gly

20 25 30

Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser Ile

35 40 45

Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn Gly Leu Tyr Leu Asn

50 55 60

Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly

65 70 75 80

His His Asn Thr Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser

85 90 95

Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys

100 105 110

Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile

115 120 125

Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

130 135 140

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

145 150 155 160

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr Ser

165 170 175

Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr Ile Asn

180 185 190

Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile Asn Ile Asn

195 200 205

Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile Ile Val Leu Asn

210 215 220

Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn Leu Asp Ser Ser Ser

225 230 235 240

Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp Phe Ile Leu Val Arg

245 250 255

Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln Lys Ile Arg Ile Lys

260 265 270

Gly Ile Leu Ser Asn Thr Gln Ser Phe

275 280

<210> 264

<211> 240

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 264

Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly

1 5 10 15

Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys

20 25 30

Glu Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg

35 40 45

Gly Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asn Lys Ile Ser Tyr

50 55 60

Glu Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu

65 70 75 80

Phe Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro

85 90 95

Gly Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile

100 105 110

Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly Ala Gly Lys

115 120 125

Asp Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu

130 135 140

Ser Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser

145 150 155 160

Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

165 170 175

Ser Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val

180 185 190

Lys Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile

195 200 205

Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

210 215 220

Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser

225 230 235 240

<210> 265

<211> 782

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 265

Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly

1 5 10 15

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

20 25 30

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

35 40 45

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

50 55 60

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

65 70 75 80

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

85 90 95

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

100 105 110

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

115 120 125

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

130 135 140

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

145 150 155 160

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

165 170 175

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

180 185 190

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

195 200 205

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

210 215 220

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

225 230 235 240

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

245 250 255

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

260 265 270

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

275 280 285

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

290 295 300

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

305 310 315 320

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

325 330 335

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

340 345 350

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

355 360 365

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

370 375 380

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

385 390 395 400

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

405 410 415

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

420 425 430

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

435 440 445

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

450 455 460

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

465 470 475 480

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

485 490 495

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

500 505 510

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

515 520 525

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

530 535 540

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

545 550 555 560

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

565 570 575

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

580 585 590

Ile His Tyr Ile Val Gln Leu Gln Gly Asn Lys Ile Ser Tyr Glu Ala

595 600 605

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

610 615 620

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

625 630 635 640

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

645 650 655

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly Ala Gly Lys Asp Glu

660 665 670

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

675 680 685

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

690 695 700

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

705 710 715 720

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

725 730 735

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

740 745 750

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

755 760 765

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser

770 775 780

<210> 266

<211> 558

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 266

Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly

1 5 10 15

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

20 25 30

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

35 40 45

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

50 55 60

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

65 70 75 80

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

85 90 95

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

100 105 110

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

115 120 125

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

130 135 140

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

145 150 155 160

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

165 170 175

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

180 185 190

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

195 200 205

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

210 215 220

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

225 230 235 240

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

245 250 255

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

260 265 270

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

275 280 285

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

290 295 300

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

305 310 315 320

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

325 330 335

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

340 345 350

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

355 360 365

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

370 375 380

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

385 390 395 400

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

405 410 415

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

420 425 430

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

435 440 445

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

450 455 460

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

465 470 475 480

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

485 490 495

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

500 505 510

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

515 520 525

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

530 535 540

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

545 550 555

<210> 267

<211> 532

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 267

Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly

1 5 10 15

Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn Pro

20 25 30

Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp Lys

35 40 45

Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr Gly Val Phe Ser

50 55 60

Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp Glu

65 70 75 80

Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp

85 90 95

Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp

100 105 110

Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys

115 120 125

Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn

130 135 140

Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys

145 150 155 160

His Tyr Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile

165 170 175

Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

180 185 190

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

195 200 205

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile Leu

210 215 220

Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr Ala Val

225 230 235 240

Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr Phe Asp Glu

245 250 255

Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile Asn Asp Gly Gln

260 265 270

Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val Gly Phe Val Thr Ile

275 280 285

Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile Ile Glu Ser Gly

290 295 300

Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Asp Asn Gly Ile

305 310 315 320

Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala

325 330 335

Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr

340 345 350

Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr

355 360 365

Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp

370 375 380

Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn

385 390 395 400

Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg

405 410 415

Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

420 425 430

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

435 440 445

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro Asp

450 455 460

Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe Glu

465 470 475 480

Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg

485 490 495

Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile

500 505 510

Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val Ile

515 520 525

Ser Glu Leu Glu

530

<210> 268

<211> 228

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 268

Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly

1 5 10 15

Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala

20 25 30

Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr

35 40 45

Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr

50 55 60

Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp

65 70 75 80

Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn

85 90 95

Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg

100 105 110

Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

115 120 125

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

130 135 140

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro Asp

145 150 155 160

Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe Glu

165 170 175

Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg

180 185 190

Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile

195 200 205

Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val Ile

210 215 220

Ser Glu Leu Glu

225

<210> 269

<211> 304

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 269

Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln Gly

1 5 10 15

Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp

20 25 30

Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys

35 40 45

Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

50 55 60

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

65 70 75 80

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly

85 90 95

Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile

100 105 110

Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly

115 120 125

Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly

130 135 140

Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr

145 150 155 160

Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met

165 170 175

Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala

180 185 190

Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu

195 200 205

Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr

210 215 220

Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu

225 230 235 240

Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val

245 250 255

Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu

260 265 270

Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp

275 280 285

Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

290 295 300

<210> 270

<211> 360

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 270

Arg Gly Ser His His His His His His His Gly Met Ala Ser Met Thr Gly

1 5 10 15

Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp Arg

20 25 30

Trp Gly Ser Ser Arg Ile Thr Arg Ala Ser Thr Gly Tyr Thr Ser Ile

35 40 45

Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

50 55 60

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

65 70 75 80

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

85 90 95

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala

100 105 110

Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

115 120 125

Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys

130 135 140

Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile

145 150 155 160

Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile

165 170 175

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

180 185 190

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

195 200 205

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys

210 215 220

Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu

225 230 235 240

Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys

245 250 255

Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly

260 265 270

Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn

275 280 285

Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu

290 295 300

Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp

305 310 315 320

Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met

325 330 335

Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe

340 345 350

Gly Val Asp Gly Val Lys Ala Pro

355 360

<210> 271

<211> 329

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<220>

<221> OPTION

<222> (327)..(327)

<223> Xaa is any amino acid

<400> 271

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn

1 5 10 15

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

20 25 30

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

35 40 45

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

50 55 60

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp

65 70 75 80

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly

85 90 95

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser

100 105 110

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe

115 120 125

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

130 135 140

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

145 150 155 160

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile

165 170 175

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile

180 185 190

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn

195 200 205

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu

210 215 220

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala

225 230 235 240

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr

245 250 255

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

260 265 270

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

275 280 285

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

290 295 300

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro

305 310 315 320

Thr Glu Ser Thr Cys Arg Xaa Gln Ala

325

<210> 272

<211> 369

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<220>

<221> OPTION

<222> (367)..(367)

<223> Xaa is any amino acid.

<220>

<221> OPTION

<222> (368)..(368)

<223> Xaa is any amino acid.

<400> 272

Arg Gly Ser His His His His His His His Gly Met Ala Ser Met Thr Gly

1 5 10 15

Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp Arg

20 25 30

Trp Gly Ser Ser Arg Ile Thr Arg Ala Ser Thr Gly Tyr Thr Ser Ile

35 40 45

Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

50 55 60

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

65 70 75 80

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

85 90 95

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala

100 105 110

Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

115 120 125

Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys

130 135 140

Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile

145 150 155 160

Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile

165 170 175

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

180 185 190

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

195 200 205

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys

210 215 220

Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu

225 230 235 240

Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys

245 250 255

Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly

260 265 270

Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn

275 280 285

Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu

290 295 300

Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp

305 310 315 320

Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met

325 330 335

Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe

340 345 350

Gly Val Asp Gly Val Lys Ala Pro Thr Glu Ser Thr Cys Arg Xaa Gln

355 360 365

Ala

<210> 273

<211> 360

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 273

Arg Gly Ser His His His His His His His Gly Met Ala Ser Met Thr Gly

1 5 10 15

Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp Arg

20 25 30

Trp Gly Ser Ser Arg Ile Thr Arg Ala Ser Thr Gly Tyr Thr Ser Ile

35 40 45

Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

50 55 60

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

65 70 75 80

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

85 90 95

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala

100 105 110

Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

115 120 125

Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys

130 135 140

Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile

145 150 155 160

Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile

165 170 175

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

180 185 190

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

195 200 205

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys

210 215 220

Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu

225 230 235 240

Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys

245 250 255

Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly

260 265 270

Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn

275 280 285

Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu

290 295 300

Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp

305 310 315 320

Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met

325 330 335

Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe

340 345 350

Gly Val Asp Gly Val Lys Ala Pro

355 360

<210> 274

<211> 329

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<220>

<221> OPTION

<222> (327)..(327)

<223> Xaa is any amino acid.

<400> 274

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn

1 5 10 15

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

20 25 30

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

35 40 45

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

50 55 60

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp

65 70 75 80

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly

85 90 95

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser

100 105 110

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe

115 120 125

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

130 135 140

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

145 150 155 160

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile

165 170 175

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile

180 185 190

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn

195 200 205

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu

210 215 220

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala

225 230 235 240

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr

245 250 255

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

260 265 270

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

275 280 285

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

290 295 300

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro

305 310 315 320

Thr Glu Ser Thr Cys Arg Xaa Gln Ala

325

<210> 275

<211> 369

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<220>

<221> OPTION

<222> (367)..(367)

<223> Xaa is any amino acid

<400> 275

Arg Gly Ser His His His His His His His Gly Met Ala Ser Met Thr Gly

1 5 10 15

Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp Arg

20 25 30

Trp Gly Ser Ser Arg Ile Thr Arg Ala Ser Thr Gly Tyr Thr Ser Ile

35 40 45

Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

50 55 60

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

65 70 75 80

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

85 90 95

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala

100 105 110

Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

115 120 125

Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys

130 135 140

Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile

145 150 155 160

Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile

165 170 175

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

180 185 190

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

195 200 205

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys

210 215 220

Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu

225 230 235 240

Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys

245 250 255

Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly

260 265 270

Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn

275 280 285

Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu

290 295 300

Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp

305 310 315 320

Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met

325 330 335

Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe

340 345 350

Gly Val Asp Gly Val Lys Ala Pro Thr Glu Ser Thr Cys Arg Xaa Gln

355 360 365

Ala

<210> 276

<211> 2710

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 276

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 277

<211> 2710

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 277

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 278

<211> 2710

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 278

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Val Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu

1355 1360 1365

Ile Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 279

<211> 2710

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 279

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 280

<211> 2710

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 280

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 281

<211> 2710

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 281

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 282

<211> 2710

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 282

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Thr Asn Thr Ala Glu Thr Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Asp Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 283

<211> 2710

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 283

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp

1235 1240 1245

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asn Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val

2465 2470 2475

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser

2495 2500 2505

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 284

<211> 2710

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 284

Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile

1 5 10 15

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu

20 25 30

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu

35 40 45

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn

50 55 60

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys

65 70 75 80

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu

100 105 110

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu

115 120 125

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile

130 135 140

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile

145 150 155 160

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu

165 170 175

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln

180 185 190

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His

195 200 205

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg

210 215 220

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg

225 230 235 240

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln

245 250 255

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg

260 265 270

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser

290 295 300

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys

325 330 335

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys

340 345 350

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser

355 360 365

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln

370 375 380

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu

385 390 395 400

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala

405 410 415

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp

420 425 430

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys

435 440 445

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr

450 455 460

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe

465 470 475 480

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp

485 490 495

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu

500 505 510

Gln Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr

515 520 525

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu

530 535 540

Asp Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr

545 550 555 560

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser

565 570 575

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser

580 585 590

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile

595 600 605

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser

610 615 620

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu

625 630 635 640

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly

645 650 655

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser

660 665 670

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile

675 680 685

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser

690 695 700

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser

705 710 715 720

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser

725 730 735

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly

740 745 750

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu

755 760 765

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser

770 775 780

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala

785 790 795 800

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser

805 810 815

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser

820 825 830

Ser Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn

835 840 845

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu

850 855 860

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu

865 870 875 880

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser

885 890 895

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr

900 905 910

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr

915 920 925

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly

930 935 940

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr

945 950 955 960

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn

965 970 975

Lys Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr

980 985 990

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln

995 1000 1005

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val

1010 1015 1020

Leu Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu

1025 1030 1035

Asp Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu

1040 1045 1050

His Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val

1055 1060 1065

Leu Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser

1070 1075 1080

Ile Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile

1085 1090 1095

Ala Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu

1100 1105 1110

Ile Leu His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His

1115 1120 1125

Leu Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp

1130 1135 1140

Lys Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp

1145 1150 1155

Phe Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala

1160 1165 1170

Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His

1175 1180 1185

Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser

1190 1195 1200

Ile Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser

1205 1210 1215

Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp

1220 1225 1230

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn

1235 1240 1245

Gly Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys

1250 1255 1260

Phe Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr

1265 1270 1275

Leu Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp

1280 1285 1290

Lys Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu

1295 1300 1305

Ile Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr

1310 1315 1320

Tyr Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn

1325 1330 1335

Leu Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val

1340 1345 1350

Arg Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu

1355 1360 1365

Ile Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu

1370 1375 1380

Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn

1385 1390 1395

Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile

1400 1405 1410

Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu

1415 1420 1425

Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn

1430 1435 1440

Thr Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile

1445 1450 1455

Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala

1460 1465 1470

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp

1475 1480 1485

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe

1490 1495 1500

Asn Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys

1505 1510 1515

Asp Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn

1520 1525 1530

Thr Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn

1535 1540 1545

Gln Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser

1550 1555 1560

Ser Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr

1565 1570 1575

Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys

1580 1585 1590

Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe

1595 1600 1605

Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys

1610 1615 1620

Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr

1625 1630 1635

Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val

1640 1645 1650

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser

1655 1660 1665

Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg

1670 1675 1680

Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu

1685 1690 1695

Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu

1700 1705 1710

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile

1715 1720 1725

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly

1730 1735 1740

Ser Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys

1745 1750 1755

Ile Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln

1760 1765 1770

Ser Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu

1775 1780 1785

Ser Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu

1790 1795 1800

Asn Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn

1805 1810 1815

Lys Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu

1820 1825 1830

Ile Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser

1835 1840 1845

Asn Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr

1850 1855 1860

Phe Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile

1865 1870 1875

Asn Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu

1880 1885 1890

Gly Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala

1895 1900 1905

Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln

1910 1915 1920

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn

1925 1930 1935

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys

1940 1945 1950

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln

1955 1960 1965

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile

1970 1975 1980

Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe

1985 1990 1995

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly

2015 2020 2025

Val Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2030 2035 2040

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

2045 2050 2055

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

2060 2065 2070

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr

2075 2080 2085

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr

2090 2095 2100

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val

2105 2110 2115

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2120 2125 2130

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2135 2140 2145

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2150 2155 2160

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2165 2170 2175

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys

2180 2185 2190

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser

2195 2200 2205

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr

2210 2215 2220

Phe Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile

2225 2230 2235

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn

2240 2245 2250

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn

2255 2260 2265

Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly

2270 2275 2280

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu

2285 2290 2295

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly

2300 2305 2310

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp

2315 2320 2325

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala

2330 2335 2340

Val Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr

2345 2350 2355

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2360 2365 2370

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser

2375 2380 2385

Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr

2390 2395 2400

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe

2405 2410 2415

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

2420 2425 2430

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2435 2440 2445

Lys Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg

2450 2455 2460

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu

2465 2470 2475

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2480 2485 2490

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn

2495 2500 2505

Asp Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly

2510 2515 2520

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2525 2530 2535

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2540 2545 2550

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn

2555 2560 2565

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr

2570 2575 2580

Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile

2585 2590 2595

Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile

2600 2605 2610

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala

2615 2620 2625

Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln

2630 2635 2640

Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn

2645 2650 2655

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

2660 2665 2670

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu

2675 2680 2685

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val

2690 2695 2700

Lys Ala Pro Gly Ile Tyr Gly

2705 2710

<210> 285

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 285

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His

2165 2170 2175

Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 286

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 286

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 287

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 287

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 288

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 288

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2465 2470 2475

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 289

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 289

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Lys Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 290

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 290

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2465 2470 2475

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 291

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 291

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Leu

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 292

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 292

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Leu

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 293

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 293

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Leu

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 294

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 294

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 295

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 295

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 296

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 296

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 297

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 297

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 298

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 298

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His

2165 2170 2175

Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 299

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 299

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 300

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 300

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 301

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 301

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 302

<211> 2708

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 302

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Gly

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Gln Gln

500 505 510

Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln Phe

515 520 525

Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp Asn

530 535 540

Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu Leu

545 550 555 560

Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys Asn

565 570 575

Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr Glu

580 585 590

Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile Ile

595 600 605

Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp Asp

610 615 620

Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg Leu

625 630 635 640

Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu Ser

660 665 670

Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser Pro

675 680 685

Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Asp

690 695 700

Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile Met

705 710 715 720

Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile Thr

725 730 735

Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Lys

740 745 750

Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala Ile

755 760 765

Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile Asp

770 775 780

Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser Ile

785 790 795 800

Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro Asp

805 810 815

Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser Ile

820 825 830

Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile Ile

835 840 845

His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu Asn

850 855 860

Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp Glu

865 870 875 880

Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr Tyr

885 890 895

Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys Glu

915 920 925

Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn Leu

930 935 940

Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys Asp

965 970 975

Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu Val

995 1000 1005

Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu Pro

1010 1015 1020

Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly

1025 1030 1035

Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp

1040 1045 1050

Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala

1055 1060 1065

Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val

1070 1075 1080

Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His Leu Ser

1115 1120 1125

Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile

1130 1135 1140

Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile Tyr

1190 1195 1200

Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys Lys

1205 1210 1215

Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp Glu

1220 1225 1230

Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr

1250 1255 1260

Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys

1265 1270 1275

Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp

1280 1285 1290

Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg

1295 1300 1305

Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser

1310 1315 1320

Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser

1325 1330 1335

Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu

1340 1345 1350

Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys

1355 1360 1365

Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile Ile

1370 1375 1380

Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys Asp

1385 1390 1395

Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser Leu

1400 1405 1410

Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu Leu

1415 1420 1425

Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile Ile

1430 1435 1440

Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala Tyr

1445 1450 1455

Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile Ser

1460 1465 1470

Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser Lys

1475 1480 1485

Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser

1490 1495 1500

Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp

1505 1510 1515

Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp

1520 1525 1530

Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val

1535 1540 1545

Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr

1550 1555 1560

Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser Asn

1565 1570 1575

Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe

1580 1585 1590

Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr Leu

1595 1600 1605

Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp Asn

1610 1615 1620

Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser Ser

1625 1630 1635

Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val Val

1640 1645 1650

Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr Ser

1655 1660 1665

Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr Ile

1670 1675 1680

Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile Asn

1685 1690 1695

Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile Ile

1700 1705 1710

Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn Leu

1715 1720 1725

Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp

1730 1735 1740

Phe Ile Leu Val Arg Tyr Leu Glu Ser Asn Lys Lys Ile Leu

1745 1750 1755

Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe

1760 1765 1770

Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser Leu

1775 1780 1785

Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn Glu

1790 1795 1800

Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys Thr

1805 1810 1815

Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile Asn

1820 1825 1830

Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu

1835 1840 1845

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp

1850 1855 1860

Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn Gly

1865 1870 1875

Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly Val

1880 1885 1890

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

1895 1900 1905

Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

1910 1915 1920

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser

1925 1930 1935

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr Tyr

1940 1945 1950

Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile

1955 1960 1965

Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser

1970 1975 1980

Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr

1985 1990 1995

Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys

2000 2005 2010

His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe

2015 2020 2025

Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr

2030 2035 2040

Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe

2045 2050 2055

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys

2060 2065 2070

Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe

2075 2080 2085

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2090 2095 2100

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr

2105 2110 2115

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn

2120 2125 2130

Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His

2135 2140 2145

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys

2150 2155 2160

Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala

2165 2170 2175

Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu

2180 2185 2190

Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala

2195 2200 2205

Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn

2210 2215 2220

Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn

2225 2230 2235

Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr

2240 2245 2250

Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu

2255 2260 2265

Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2270 2275 2280

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2285 2290 2295

Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2300 2305 2310

Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr

2315 2320 2325

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala

2330 2335 2340

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2345 2350 2355

Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly

2360 2365 2370

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly

2375 2380 2385

Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly

2390 2395 2400

Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr

2405 2410 2415

Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala

2420 2425 2430

Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

2435 2440 2445

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

2450 2455 2460

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val

2465 2470 2475

Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr

2480 2485 2490

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys

2495 2500 2505

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2510 2515 2520

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2525 2530 2535

Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe

2540 2545 2550

Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys

2555 2560 2565

Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe

2570 2575 2580

Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp

2585 2590 2595

Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val

2600 2605 2610

Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2615 2620 2625

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2630 2635 2640

Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser

2645 2650 2655

Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr

2660 2665 2670

Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

2675 2680 2685

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

2690 2695 2700

Pro Gly Ile Tyr Gly

2705

<210> 303

<211> 2708

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 303

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Gln Gln

500 505 510

Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln Phe

515 520 525

Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp Asn

530 535 540

Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu Leu

545 550 555 560

Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys Asn

565 570 575

Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr Glu

580 585 590

Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile Ile

595 600 605

Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp Asp

610 615 620

Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg Leu

625 630 635 640

Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys Asp

645 650 655

Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu Ser

660 665 670

Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser Pro

675 680 685

Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Asp

690 695 700

Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile Met

705 710 715 720

Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile Thr

725 730 735

Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Lys

740 745 750

Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala Ile

755 760 765

Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile Asp

770 775 780

Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser Ile

785 790 795 800

Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro Asp

805 810 815

Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser Ile

820 825 830

Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile Ile

835 840 845

His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu Asn

850 855 860

Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp Glu

865 870 875 880

Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr Tyr

885 890 895

Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val Glu

900 905 910

Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys Glu

915 920 925

Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn Leu

930 935 940

Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys Asp

965 970 975

Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu Val

995 1000 1005

Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu Pro

1010 1015 1020

Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly

1025 1030 1035

Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp

1040 1045 1050

Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala

1055 1060 1065

Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val

1070 1075 1080

Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

His Asp Lys Ala Thr Ser Val Val Asn Tyr Phe Asn His Leu Ser

1115 1120 1125

Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys Ile

1130 1135 1140

Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile Tyr

1190 1195 1200

Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys Lys

1205 1210 1215

Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp Glu

1220 1225 1230

Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr

1250 1255 1260

Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys

1265 1270 1275

Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp

1280 1285 1290

Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg

1295 1300 1305

Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser

1310 1315 1320

Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser

1325 1330 1335

Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu

1340 1345 1350

Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys

1355 1360 1365

Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile Ile

1370 1375 1380

Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys Asp

1385 1390 1395

Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser Leu

1400 1405 1410

Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu Leu

1415 1420 1425

Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr Ile

1430 1435 1440

Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala Tyr

1445 1450 1455

Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile Ser

1460 1465 1470

Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser Lys

1475 1480 1485

Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser

1490 1495 1500

Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp

1505 1510 1515

Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp

1520 1525 1530

Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val

1535 1540 1545

Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr

1550 1555 1560

Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser Asn

1565 1570 1575

Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe

1580 1585 1590

Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr Leu

1595 1600 1605

Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp Asn

1610 1615 1620

Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser Ser

1625 1630 1635

Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val Val

1640 1645 1650

Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr Ser

1655 1660 1665

Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr Ile

1670 1675 1680

Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile Asn

1685 1690 1695

Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile Ile

1700 1705 1710

Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn Leu

1715 1720 1725

Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp

1730 1735 1740

Phe Ile Leu Val Arg Tyr Leu Glu Ser Asn Lys Lys Ile Leu

1745 1750 1755

Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe

1760 1765 1770

Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser Leu

1775 1780 1785

Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn Glu

1790 1795 1800

Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys Thr

1805 1810 1815

Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile Asn

1820 1825 1830

Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu

1835 1840 1845

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp

1850 1855 1860

Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn Gly

1865 1870 1875

Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly Val

1880 1885 1890

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

1895 1900 1905

Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

1910 1915 1920

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser

1925 1930 1935

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr Tyr

1940 1945 1950

Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile

1955 1960 1965

Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser

1970 1975 1980

Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr

1985 1990 1995

Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys

2000 2005 2010

His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe

2015 2020 2025

Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr

2030 2035 2040

Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe

2045 2050 2055

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys

2060 2065 2070

Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe

2075 2080 2085

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2090 2095 2100

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr

2105 2110 2115

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn

2120 2125 2130

Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His

2135 2140 2145

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys

2150 2155 2160

Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala

2165 2170 2175

Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu

2180 2185 2190

Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala

2195 2200 2205

Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn

2210 2215 2220

Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn

2225 2230 2235

Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr

2240 2245 2250

Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu

2255 2260 2265

Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2270 2275 2280

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2285 2290 2295

Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2300 2305 2310

Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr

2315 2320 2325

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala

2330 2335 2340

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2345 2350 2355

Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly

2360 2365 2370

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly

2375 2380 2385

Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly

2390 2395 2400

Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr

2405 2410 2415

Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala

2420 2425 2430

Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr

2435 2440 2445

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

2450 2455 2460

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val

2465 2470 2475

Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr

2480 2485 2490

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys

2495 2500 2505

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2510 2515 2520

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2525 2530 2535

Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe

2540 2545 2550

Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys

2555 2560 2565

Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe

2570 2575 2580

Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp

2585 2590 2595

Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val

2600 2605 2610

Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2615 2620 2625

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2630 2635 2640

Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser

2645 2650 2655

Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr

2660 2665 2670

Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu

2675 2680 2685

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

2690 2695 2700

Pro Gly Ile Tyr Gly

2705

<210> 304

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 304

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 305

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 305

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asn Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Gly Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 306

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 306

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asn Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Gly Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 307

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 307

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 308

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 308

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 309

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 309

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asn Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 310

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 310

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 311

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 311

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asn Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Gly Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 312

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 312

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 313

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 313

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Ala Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 314

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 314

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 315

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 315

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2465 2470 2475

Ala Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 316

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 316

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 317

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 317

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 318

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 318

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 319

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 319

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2465 2470 2475

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 320

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 320

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Gly

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 321

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 321

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 322

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 322

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asn Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 323

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 323

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Ala Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Gln Ile Asn Ser Leu Ala Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 324

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 324

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

His Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Val

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys Asp

705 710 715 720

Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu

1115 1120 1125

Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn

1325 1330 1335

Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Ser

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys Pro

1490 1495 1500

Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys Ile

1715 1720 1725

Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly Asn

1760 1765 1770

Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile

1835 1840 1845

Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr

1865 1870 1875

Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly

1925 1930 1935

Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu

1940 1945 1950

Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile

2090 2095 2100

Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp Gly

2255 2260 2265

Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe Tyr

2270 2275 2280

Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 325

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 325

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

His Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 326

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 326

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

His Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Val

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys Asp

705 710 715 720

Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu

1115 1120 1125

Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn

1325 1330 1335

Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Ser

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys Pro

1490 1495 1500

Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys Ile

1715 1720 1725

Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly Asn

1760 1765 1770

Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile

1835 1840 1845

Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr

1865 1870 1875

Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly

1925 1930 1935

Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu

1940 1945 1950

Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile

2090 2095 2100

Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp Gly

2255 2260 2265

Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe Tyr

2270 2275 2280

Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 327

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 327

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

His Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 328

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 328

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

His Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Arg Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 329

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 329

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

His Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 330

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 330

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 331

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 331

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 332

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 332

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 333

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 333

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Val

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys Asp

705 710 715 720

Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu

1115 1120 1125

Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn

1325 1330 1335

Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Ser

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys Pro

1490 1495 1500

Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys Ile

1715 1720 1725

Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly Asn

1760 1765 1770

Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile

1835 1840 1845

Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr

1865 1870 1875

Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly

1925 1930 1935

Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu

1940 1945 1950

Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile

2090 2095 2100

Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp Gly

2255 2260 2265

Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe Tyr

2270 2275 2280

Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 334

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 334

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Asp Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 335

<211> 2366

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 335

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Ile

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys His Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Gln Lys Asn Ser Leu Ala Gln Phe Asn Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Thr Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg Gly

565 570 575

Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Thr

610 615 620

Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Ala

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Ser Glu Ile Glu Thr Ala Ile Gly Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Met Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Val

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 336

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 336

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 337

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 337

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 338

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 338

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 339

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 339

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 340

<211> 2366

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 340

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Gln Lys Asn Ser Leu Ala Gln Phe Asn Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Ile Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg Gly

565 570 575

Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Thr

610 615 620

Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Leu Ile Gly His Gly Lys Ala

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Ser Glu Ile Glu Thr Ile Ile Asp Leu Ala Lys Ala Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser

1115 1120 1125

Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Lys Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Gly Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Gly Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Gln Tyr Glu Gly Gln Phe Tyr

1250 1255 1260

Trp Arg Phe Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Val Arg Ile Ser Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu

1325 1330 1335

Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Ser Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Ser Asp Val Val Leu Ile Ile Lys Val Tyr Met Asp Asn Ser Lys

1490 1495 1500

Pro Pro Phe Gly Tyr Tyr Ser Asn Asp Leu Lys Asp Val Lys Ala

1505 1510 1515

Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Lys Asn

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Ile Lys Ser Leu Lys Ser Asn Ala Lys Leu Ile Leu Asp Thr

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys

1715 1720 1725

Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly

1760 1765 1770

Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Ser Ile Asn Lys Ile Ile Ser Thr Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Val Glu Gly Leu Leu Asn Tyr His Leu Gly Leu Ile Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu

1865 1870 1875

Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Pro Asn Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Val Tyr Tyr Phe

1925 1930 1935

Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp

1940 1945 1950

Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Ser Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Thr

2090 2095 2100

Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln

2105 2110 2115

Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp

2255 2260 2265

Gly Ile Met Gln Tyr Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Asn Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Ala Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Ile

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Glu Leu Val Ile Ser Glu

2360 2365

<210> 341

<211> 2366

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 341

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Gln Lys Asn Ser Leu Ala Gln Phe Asn Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Ile Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg Gly

565 570 575

Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Thr

610 615 620

Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Leu Ile Gly His Gly Lys Ala

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Ser Glu Ile Glu Thr Ile Ile Asp Leu Ala Lys Ala Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser

1115 1120 1125

Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Lys Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Gly Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Gly Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Gln Tyr Glu Gly Gln Phe Tyr

1250 1255 1260

Trp Arg Phe Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Val Arg Ile Ser Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu

1325 1330 1335

Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Ser Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Ser Asp Val Val Leu Ile Ile Lys Val Tyr Met Asp Asn Ser Lys

1490 1495 1500

Pro Pro Phe Gly Tyr Tyr Ser Asn Asp Leu Lys Asp Val Lys Ala

1505 1510 1515

Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Lys Asn

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Ile Lys Ser Leu Lys Ser Asn Ala Lys Leu Ile Leu Asp Thr

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys

1715 1720 1725

Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly

1760 1765 1770

Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Ser Ile Asn Lys Ile Ile Ser Thr Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Val Glu Gly Leu Leu Asn Tyr His Leu Gly Leu Ile Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu

1865 1870 1875

Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Pro Asn Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Val Tyr Tyr Phe

1925 1930 1935

Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp

1940 1945 1950

Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Ser Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Thr

2090 2095 2100

Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln

2105 2110 2115

Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp

2255 2260 2265

Gly Ile Met Gln Tyr Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Asn Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Ala Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Ile

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Glu Leu Val Ile Ser Glu

2360 2365

<210> 342

<211> 2366

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 342

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Gln Lys Asn Ser Leu Ala Gln Phe Asn Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Ile Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg Gly

565 570 575

Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Thr

610 615 620

Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Leu Ile Gly His Gly Lys Ala

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Ser Glu Ile Glu Thr Ile Ile Asp Leu Ala Lys Ala Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser

1115 1120 1125

Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Lys Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Gly Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Gly Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Gln Tyr Glu Gly Gln Phe Tyr

1250 1255 1260

Trp Arg Phe Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Val Arg Ile Ser Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu

1325 1330 1335

Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Ser Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Cys Ser Thr Lys Asp Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Ser Asp Val Val Leu Ile Ile Lys Val Tyr Met Asp Asn Ser Lys

1490 1495 1500

Pro Pro Phe Gly Tyr Tyr Ser Asn Asp Leu Lys Asp Val Lys Ala

1505 1510 1515

Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Lys Asn

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Ile Lys Ser Leu Lys Ser Asn Ala Lys Leu Ile Leu Asp Thr

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys

1715 1720 1725

Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly

1760 1765 1770

Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Ser Ile Asn Lys Ile Ile Ser Thr Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Val Glu Gly Leu Leu Asn Tyr His Leu Gly Leu Ile Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu

1865 1870 1875

Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Pro Asn Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Val Tyr Tyr Phe

1925 1930 1935

Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp

1940 1945 1950

Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Ser Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Thr

2090 2095 2100

Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln

2105 2110 2115

Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp

2255 2260 2265

Gly Ile Met Gln Tyr Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Asn Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Ala Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Ile

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Glu Leu Val Ile Ser Glu

2360 2365

<210> 343

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 343

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 344

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 344

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 345

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 345

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Leu Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 346

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 346

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 347

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 347

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Val

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys Asp

705 710 715 720

Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu

1115 1120 1125

Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn

1325 1330 1335

Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Ser

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys Pro

1490 1495 1500

Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys Ile

1715 1720 1725

Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly Asn

1760 1765 1770

Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile

1835 1840 1845

Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr

1865 1870 1875

Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly

1925 1930 1935

Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu

1940 1945 1950

Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile

2090 2095 2100

Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp Gly

2255 2260 2265

Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe Tyr

2270 2275 2280

Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 348

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 348

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 349

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 349

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 350

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 350

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 351

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 351

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 352

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 352

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 353

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 353

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 354

<211> 2366

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 354

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Ile

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys His Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Gln Lys Asn Ser Leu Ala Gln Phe Asn Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Thr Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg Gly

565 570 575

Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Thr

610 615 620

Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Ala

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Ser Glu Ile Glu Thr Ala Ile Gly Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Met Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Val

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 355

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 355

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 356

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 356

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 357

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 357

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 358

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 358

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 359

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 359

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 360

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 360

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 361

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 361

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Glu Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 362

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 362

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 363

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 363

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 364

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 364

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 365

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 365

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 366

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 366

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 367

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 367

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 368

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 368

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 369

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 369

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 370

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 370

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 371

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 371

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 372

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 372

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Ile

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 373

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 373

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Ala Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Gln Met Ala Ser Leu Ala Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 374

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 374

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asp Ser Lys Ala Ala Thr Gly Trp Ala Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 375

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 375

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 376

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 376

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asp Ser Lys Ala Ala Thr Gly Trp Ala Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 377

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 377

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 378

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 378

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 379

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 379

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 380

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 380

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr

85 90 95

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Arg Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala

195 200 205

Asn Gly Tyr Lys Ile Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 381

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 381

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 382

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 382

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr

85 90 95

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Arg Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala

195 200 205

Asn Gly Tyr Lys Ile Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 383

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 383

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asp Ser Lys Ala Ala Thr Gly Trp Ala Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 384

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 384

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 385

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 385

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 386

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 386

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr

85 90 95

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Arg Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala

195 200 205

Asn Gly Tyr Lys Ile Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 387

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 387

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 388

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 388

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr

85 90 95

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Arg Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala

195 200 205

Asn Gly Tyr Lys Ile Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 389

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 389

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asp Ser Lys Ala Ala Thr Gly Trp Ala Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 390

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 390

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asp Ser Lys Ala Ala Thr Gly Trp Ala Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 391

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 391

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asp Ser Lys Ala Ala Thr Gly Trp Ala Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 392

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 392

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 393

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 393

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 394

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 394

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 395

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 395

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 396

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 396

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asp Ser Lys Ala Ala Thr Gly Trp Ala Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 397

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 397

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 398

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 398

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 399

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 399

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 400

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 400

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 401

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 401

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 402

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 402

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 403

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 403

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 404

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 404

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 405

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 405

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 406

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 406

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 407

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 407

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 408

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 408

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 409

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 409

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 410

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 410

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 411

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 411

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Ala Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Arg Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala

195 200 205

Asn Gly Tyr Lys Ile Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 412

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 412

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 413

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 413

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Arg Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala

195 200 205

Asn Gly Tyr Lys Ile Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 414

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 414

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 415

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 415

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Arg Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala

195 200 205

Asn Gly Tyr Lys Ile Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 416

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 416

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Arg Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala

195 200 205

Asn Gly Tyr Lys Ile Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 417

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 417

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr

85 90 95

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Arg Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala

195 200 205

Asn Gly Tyr Lys Ile Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 418

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 418

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 419

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 419

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Arg Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Ile Gly Ala

195 200 205

Asn Gly Tyr Lys Ile Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 420

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 420

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 421

<211> 321

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 421

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe

1 5 10 15

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly

20 25 30

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly

35 40 45

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

50 55 60

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile

65 70 75 80

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr

85 90 95

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr

100 105 110

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr

115 120 125

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp

130 135 140

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu

145 150 155 160

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn

165 170 175

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr

180 185 190

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala

195 200 205

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly

210 215 220

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe

225 230 235 240

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg

245 250 255

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly

260 265 270

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val

275 280 285

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

290 295 300

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala

305 310 315 320

Pro

<210> 422

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 422

Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Thr Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Ser Ile Asn Lys Val Ile

35 40 45

Ser Thr Phe Thr Pro Ser Tyr Tyr Val Glu Gly Leu Leu Asn Tyr Asp

50 55 60

Leu Gly Leu Ile Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val

115 120 125

Gly Glu Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly Asp

180 185 190

Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu Val Tyr

195 200 205

Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ala Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asp Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Leu Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Ile Ser Ile Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile

355 360 365

Met Gln Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asp Pro Glu Thr

465 470 475 480

Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Thr Phe Glu Asp

500 505 510

Asn His Tyr Tyr Phe Asn Glu Asp Gly Ile Met Gln Tyr Gly Tyr Leu

515 520 525

Asn Ile Glu Asp Lys Thr Phe Tyr Phe Ser Glu Asp Gly Ile Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 423

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 423

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 424

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 424

Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Thr Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Ser Ile Asn Lys Val Ile

35 40 45

Ser Thr Phe Thr Pro Ser Tyr Tyr Val Glu Gly Leu Leu Asn Tyr Asp

50 55 60

Leu Gly Leu Ile Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val

115 120 125

Gly Glu Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly Asp

180 185 190

Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu Val Tyr

195 200 205

Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ala Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asp Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Leu Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Ile Ser Ile Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile

355 360 365

Met Gln Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asp Pro Glu Thr

465 470 475 480

Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Thr Phe Glu Asp

500 505 510

Asn His Tyr Tyr Phe Asn Glu Asp Gly Ile Met Gln Tyr Gly Tyr Leu

515 520 525

Asn Ile Glu Asp Lys Thr Phe Tyr Phe Ser Glu Asp Gly Ile Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 425

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 425

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 426

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 426

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 427

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 427

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 428

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 428

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 429

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 429

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 430

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 430

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 431

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 431

Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Thr Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Ser Ile Asn Lys Val Ile

35 40 45

Ser Thr Phe Thr Pro Ser Tyr Tyr Val Glu Gly Leu Leu Asn Tyr Asp

50 55 60

Leu Gly Leu Ile Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val

115 120 125

Gly Glu Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly Asp

180 185 190

Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu Val Tyr

195 200 205

Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ala Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asp Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Leu Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Ile Ser Ile Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile

355 360 365

Met Gln Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asp Pro Glu Thr

465 470 475 480

Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Thr Phe Glu Asp

500 505 510

Asn His Tyr Tyr Phe Asn Glu Asp Gly Ile Met Gln Tyr Gly Tyr Leu

515 520 525

Asn Ile Glu Asp Lys Thr Phe Tyr Phe Ser Glu Asp Gly Ile Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 432

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 432

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 433

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 433

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asp Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 434

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 434

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 435

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 435

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 436

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 436

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 437

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 437

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 438

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 438

Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Thr Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Ser Ile Asn Lys Ile Ile

35 40 45

Ser Thr Phe Thr Pro Ser Tyr Tyr Val Glu Gly Leu Leu Asn Tyr His

50 55 60

Leu Gly Leu Ile Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val

115 120 125

Gly Glu Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Pro Asn Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Val Tyr Tyr Phe Gly Asp

180 185 190

Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu Val Tyr

195 200 205

Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ala Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asp Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Leu Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Ser Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Ile Ser Thr Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile

355 360 365

Met Gln Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asp Pro Glu Thr

465 470 475 480

Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Thr Phe Glu Asp

500 505 510

Asn His Tyr Tyr Phe Asn Glu Asp Gly Ile Met Gln Tyr Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Asn Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Ile Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 439

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 439

Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Thr Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Ser Ile Asn Lys Ile Ile

35 40 45

Ser Thr Phe Thr Pro Ser Tyr Tyr Val Glu Gly Leu Leu Asn Tyr His

50 55 60

Leu Gly Leu Ile Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val

115 120 125

Gly Glu Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Pro Asn Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Val Tyr Tyr Phe Gly Asp

180 185 190

Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu Val Tyr

195 200 205

Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ala Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asp Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Leu Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Ser Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Ile Ser Thr Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile

355 360 365

Met Gln Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asp Pro Glu Thr

465 470 475 480

Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Thr Phe Glu Asp

500 505 510

Asn His Tyr Tyr Phe Asn Glu Asp Gly Ile Met Gln Tyr Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Asn Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Ile Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 440

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 440

Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Thr Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Ser Ile Asn Lys Ile Ile

35 40 45

Ser Thr Phe Thr Pro Ser Tyr Tyr Val Glu Gly Leu Leu Asn Tyr His

50 55 60

Leu Gly Leu Ile Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val

115 120 125

Gly Glu Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Pro Asn Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Val Tyr Tyr Phe Gly Asp

180 185 190

Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu Val Tyr

195 200 205

Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ala Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asp Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Leu Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Ser Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Ile Ser Thr Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile

355 360 365

Met Gln Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asp Pro Glu Thr

465 470 475 480

Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Thr Phe Glu Asp

500 505 510

Asn His Tyr Tyr Phe Asn Glu Asp Gly Ile Met Gln Tyr Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Asn Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Ile Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 441

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 441

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 442

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 442

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 443

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 443

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Leu Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 444

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 444

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 445

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 445

Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Thr Asn Val Phe Lys Gly Asn Thr Ile Ser Asp Lys Ile

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Ser Ile Asn Lys Val Ile

35 40 45

Ser Thr Phe Thr Pro Ser Tyr Tyr Val Glu Gly Leu Leu Asn Tyr Asp

50 55 60

Leu Gly Leu Ile Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val

115 120 125

Gly Glu Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly Asp

180 185 190

Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu Val Tyr

195 200 205

Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ala Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asp Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Leu Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Ile Ser Ile Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile

355 360 365

Met Gln Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asp Pro Glu Thr

465 470 475 480

Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Thr Phe Glu Asp

500 505 510

Asn His Tyr Tyr Phe Asn Glu Asp Gly Ile Met Gln Tyr Gly Tyr Leu

515 520 525

Asn Ile Glu Asp Lys Thr Phe Tyr Phe Ser Glu Asp Gly Ile Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 446

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 446

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 447

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 447

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 448

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 448

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 449

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 449

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 450

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 450

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 451

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 451

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 452

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 452

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asp Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 453

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 453

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 454

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 454

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 455

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 455

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 456

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 456

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 457

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 457

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 458

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 458

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 459

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 459

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 460

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 460

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 461

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 461

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 462

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 462

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 463

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 463

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 464

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 464

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 465

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 465

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 466

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 466

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 467

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 467

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 468

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 468

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 469

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 469

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 470

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 470

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Ser Ala Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Ile Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met Tyr

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Ile Glu Ile Asp Gly Lys Tyr Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Ser Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Ala Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Tyr Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Asn Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asp Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Gln Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 471

<211> 612

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 471

Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val Ser Gln Val Lys

1 5 10 15

Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu Ala Asn Lys Leu

20 25 30

Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val Ser Glu Ile Ile

35 40 45

Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu Ile Gly Tyr Asp

50 55 60

Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe

65 70 75 80

Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr

85 90 95

Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly

100 105 110

Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile

115 120 125

Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly

130 135 140

Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

145 150 155 160

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

165 170 175

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp Asp

180 185 190

Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu Met His

195 200 205

Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu Asn Gln Ile

210 215 220

Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val Met Gln Lys Gly

225 230 235 240

Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp Asp Ser Gly Val

245 250 255

Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His Phe Tyr Phe Ala

260 265 270

Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr Glu Asp Gly Phe

275 280 285

Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn Glu Glu Gly Glu

290 295 300

Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr

305 310 315 320

Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp

325 330 335

Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly

340 345 350

Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile

355 360 365

Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser

370 375 380

Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

385 390 395 400

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

405 410 415

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn

420 425 430

Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu

435 440 445

Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile

450 455 460

Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr

465 470 475 480

Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr

485 490 495

Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn

500 505 510

Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile

515 520 525

Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln

530 535 540

Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln

545 550 555 560

Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly

565 570 575

Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile

580 585 590

Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp

595 600 605

Pro Asp Thr Ala

610

<210> 472

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 472

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 473

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 473

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 474

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 474

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 475

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 475

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 476

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 476

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 477

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 477

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 478

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 478

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 479

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 479

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 480

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 480

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 481

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 481

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 482

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 482

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 483

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 483

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 484

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 484

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 485

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 485

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 486

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 486

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 487

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 487

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 488

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 488

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 489

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 489

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 490

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 490

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 491

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 491

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 492

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 492

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 493

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 493

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 494

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 494

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 495

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 495

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 496

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 496

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 497

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 497

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 498

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 498

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Gly

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 499

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 499

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 500

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 500

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 501

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 501

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 502

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 502

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 503

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 503

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 504

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 504

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 505

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 505

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 506

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 506

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 507

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 507

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 508

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 508

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 509

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 509

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 510

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 510

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 511

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 511

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 512

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 512

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 513

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 513

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 514

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 514

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 515

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 515

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 516

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 516

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Gly

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 517

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 517

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 518

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 518

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 519

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 519

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 520

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 520

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 521

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 521

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 522

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 522

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 523

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 523

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 524

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 524

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 525

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 525

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 526

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 526

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 527

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 527

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 528

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 528

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 529

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 529

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 530

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 530

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 531

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 531

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 532

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 532

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 533

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 533

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 534

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 534

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 535

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 535

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 536

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 536

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 537

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 537

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 538

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 538

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 539

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 539

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 540

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 540

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 541

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 541

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 542

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 542

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 543

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 543

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 544

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 544

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 545

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 545

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 546

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 546

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Gly

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 547

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 547

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 548

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 548

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 549

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 549

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 550

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 550

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 551

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 551

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 552

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 552

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 553

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 553

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 554

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 554

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 555

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 555

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 556

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 556

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 557

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 557

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 558

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 558

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 559

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 559

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 560

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 560

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 561

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 561

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 562

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 562

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 563

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 563

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 564

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 564

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Gly

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 565

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 565

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 566

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 566

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 567

<211> 540

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 567

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser

530 535 540

<210> 568

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 568

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 569

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 569

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 570

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 570

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 571

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 571

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 572

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 572

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 573

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 573

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 574

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 574

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 575

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 575

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 576

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 576

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 577

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 577

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 578

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 578

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 579

<211> 543

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 579

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Ile

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys His Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

<210> 580

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 580

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 581

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 581

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 582

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 582

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 583

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 583

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 584

<211> 543

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 584

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

<210> 585

<211> 543

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 585

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

<210> 586

<211> 543

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 586

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

<210> 587

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 587

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 588

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 588

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 589

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 589

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 590

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 590

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 591

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 591

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 592

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 592

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 593

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 593

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 594

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 594

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 595

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 595

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 596

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 596

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 597

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 597

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 598

<211> 543

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 598

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Ile

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys His Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

<210> 599

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 599

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 600

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 600

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 601

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 601

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 602

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 602

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 603

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 603

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 604

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 604

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 605

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 605

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 606

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 606

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 607

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 607

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 608

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 608

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 609

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 609

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 610

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 610

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 611

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 611

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 612

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 612

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 613

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 613

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 614

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 614

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 615

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 615

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Ile

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 616

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 616

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 617

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 617

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 618

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 618

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 619

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 619

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 620

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 620

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 621

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 621

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 622

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 622

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 623

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 623

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 624

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 624

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 625

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 625

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 626

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 626

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 627

<211> 543

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 627

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Ile

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Ala Ile Leu Ala

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys His Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

<210> 628

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 628

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 629

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 629

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 630

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 630

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 631

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 631

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 632

<211> 543

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 632

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Ala Ile Leu Ala

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

<210> 633

<211> 543

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 633

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Ala Ile Leu Ala

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

<210> 634

<211> 543

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 634

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Ala Ile Leu Ala

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

<210> 635

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 635

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 636

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 636

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 637

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 637

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 638

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 638

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 639

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 639

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 640

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 640

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 641

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 641

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 642

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 642

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 643

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 643

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 644

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 644

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 645

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 645

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 646

<211> 543

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 646

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Ile

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Ala Ile Leu Ala

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys His Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu

530 535 540

<210> 647

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 647

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 648

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 648

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 649

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 649

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 650

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 650

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 651

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 651

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 652

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 652

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 653

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 653

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 654

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 654

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 655

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 655

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 656

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 656

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 657

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 657

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 658

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 658

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 659

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 659

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 660

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 660

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 661

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 661

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 662

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 662

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 663

<211> 542

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 663

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Ile

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu

530 535 540

<210> 664

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 664

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His

2165 2170 2175

Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 665

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 665

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 666

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 666

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His

2165 2170 2175

Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 667

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 667

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 668

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 668

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 669

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 669

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 670

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 670

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Thr Asn Thr Ala Glu Thr Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2465 2470 2475

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 671

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 671

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 672

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 672

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2465 2470 2475

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 673

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 673

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His

2165 2170 2175

Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 674

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 674

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 675

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 675

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 676

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 676

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2465 2470 2475

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 677

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 677

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Lys Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 678

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 678

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2465 2470 2475

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 679

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 679

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Leu

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 680

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 680

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Leu

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 681

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 681

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Thr Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Leu

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 682

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 682

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 683

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 683

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 684

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 684

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 685

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 685

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 686

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 686

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Pro Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Tyr Ile Ser Ser His Ile Pro Ser Leu Ser Val

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Thr Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asp Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Met Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Asn Leu Ile

1355 1360 1365

Glu Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asn Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Ser Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

Tyr Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Val Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His

2165 2170 2175

Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Ile Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Glu Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Arg Tyr Tyr Phe Asn Thr Asn Thr Tyr Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Tyr Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asp Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Ala Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Ser Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 687

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 687

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 688

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 688

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 689

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 689

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 690

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 690

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Gly

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 691

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 691

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 692

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 692

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 693

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 693

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asn Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Gly Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 694

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 694

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asn Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Gly Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 695

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 695

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 696

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 696

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 697

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 697

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asn Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 698

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 698

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Val Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 699

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 699

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asn Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Gly Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 700

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 700

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 701

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 701

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Ala Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 702

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 702

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 703

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 703

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2465 2470 2475

Ala Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 704

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 704

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 705

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 705

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 706

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 706

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 707

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 707

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Val Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala

2465 2470 2475

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Asp

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 708

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 708

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Gly

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Ile

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 709

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 709

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Asn Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Val Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Tyr Asn Arg Asp Glu Thr Leu Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Glu Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asp Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Thr Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Val Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Leu Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Glu Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ala Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Lys Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asn Gly

1235 1240 1245

Thr Lys Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Gly Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Ala Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ala Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Val Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Val Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Ala Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Ser Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asn Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Arg Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Ala Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Thr His Leu Tyr Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Val

2330 2335 2340

Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Ala Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Arg Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Ile Gly Ala Asn Gly Tyr Lys Ile Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Asp Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Asn Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Asn Met Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 710

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 710

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asn Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asp Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 711

<211> 2709

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 711

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg

1 5 10 15

Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr

20 25 30

Asn Lys Leu Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys

35 40 45

Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser

50 55 60

Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu

65 70 75 80

Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu

85 90 95

His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr

100 105 110

Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp

115 120 125

Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val

130 135 140

Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln

145 150 155 160

Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe

165 170 175

Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile

180 185 190

Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu

195 200 205

Val Ser Glu Ser Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr

210 215 220

Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala

225 230 235 240

Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu

245 250 255

Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu

260 265 270

Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu

275 280 285

Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser

290 295 300

Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys

305 310 315 320

Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu

325 330 335

Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser

340 345 350

Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp

355 360 365

Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala

370 375 380

Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln

385 390 395 400

Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile

405 410 415

Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser

420 425 430

Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile

435 440 445

Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile

450 455 460

Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile

465 470 475 480

Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu

485 490 495

Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln

500 505 510

Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln

515 520 525

Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp

530 535 540

Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu

545 550 555 560

Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys

565 570 575

Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr

580 585 590

Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile

595 600 605

Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp

610 615 620

Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg

625 630 635 640

Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys

645 650 655

Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu

660 665 670

Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser

675 680 685

Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr

690 695 700

Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile

705 710 715 720

Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile

725 730 735

Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg

740 745 750

Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala

755 760 765

Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile

770 775 780

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser

785 790 795 800

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro

805 810 815

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser

820 825 830

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile

835 840 845

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu

850 855 860

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp

865 870 875 880

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr

885 890 895

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val

900 905 910

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys

915 920 925

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn

930 935 940

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu

945 950 955 960

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys

965 970 975

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala

980 985 990

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu

995 1000 1005

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu

1010 1015 1020

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp

1025 1030 1035

Gly Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His

1040 1045 1050

Asp Pro Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu

1055 1060 1065

Ala Ile Asn Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile

1070 1075 1080

Val Gly Ile Gly Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala

1085 1090 1095

Gly Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile

1100 1105 1110

Leu His Asp Lys Ala Thr Ser Val Asn Tyr Phe Asn His Leu

1115 1120 1125

Ser Glu Ser Lys Lys Tyr Gly Pro Leu Lys Thr Glu Asp Asp Lys

1130 1135 1140

Ile Leu Val Pro Ile Asp Asp Leu Val Ile Ser Glu Ile Asp Phe

1145 1150 1155

Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys Asn Ile Leu Ala Met

1160 1165 1170

Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn Ile Asp His Phe

1175 1180 1185

Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser Leu Ser Ile

1190 1195 1200

Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe Ser Lys

1205 1210 1215

Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp Trp

1220 1225 1230

Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly

1235 1240 1245

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe

1250 1255 1260

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Leu

1265 1270 1275

Lys Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys

1280 1285 1290

Asp Thr Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile

1295 1300 1305

Arg Asn Lys Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr

1310 1315 1320

Ser Leu Leu Leu Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu

1325 1330 1335

Ser Lys Asp Asp Leu Trp Ile Phe Asn Ile Asp Asn Glu Val Arg

1340 1345 1350

Glu Ile Ser Ile Glu Asn Gly Thr Ile Lys Lys Gly Lys Leu Ile

1355 1360 1365

Lys Asp Val Leu Ser Lys Ile Asp Ile Asn Lys Asn Lys Leu Ile

1370 1375 1380

Ile Gly Asn Gln Thr Ile Asp Phe Ser Gly Asp Ile Asp Asn Lys

1385 1390 1395

Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu Asp Asp Lys Ile Ser

1400 1405 1410

Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser Tyr Ser Leu Leu

1415 1420 1425

Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu Ser Asn Thr

1430 1435 1440

Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn Ile Ala

1445 1450 1455

Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala Ile

1460 1465 1470

Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser

1475 1480 1485

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn

1490 1495 1500

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp

1505 1510 1515

Asp Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr

1520 1525 1530

Asp Lys Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln

1535 1540 1545

Val Lys Val Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser

1550 1555 1560

Tyr Leu Asp Phe Val Lys Asn Ser Asp Gly His His Asn Thr Ser

1565 1570 1575

Asn Phe Met Asn Leu Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu

1580 1585 1590

Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp Lys Tyr Phe Thr

1595 1600 1605

Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe Ile Cys Asp

1610 1615 1620

Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys Thr Ser

1625 1630 1635

Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val Val

1640 1645 1650

Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr

1655 1660 1665

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr

1670 1675 1680

Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile

1685 1690 1695

Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile

1700 1705 1710

Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn

1715 1720 1725

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser

1730 1735 1740

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile

1745 1750 1755

Leu Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser

1760 1765 1770

Phe Asn Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser

1775 1780 1785

Leu Gly Tyr Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn

1790 1795 1800

Glu Leu Asp Arg Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys

1805 1810 1815

Thr Tyr Tyr Tyr Asp Glu Asp Ser Lys Leu Val Lys Gly Leu Ile

1820 1825 1830

Asn Ile Asn Asn Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn

1835 1840 1845

Leu Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe

1850 1855 1860

Asp Ile Asn Thr Gly Ala Ala Leu Thr Ser Tyr Lys Ile Ile Asn

1865 1870 1875

Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val Met Gln Leu Gly

1880 1885 1890

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn

1895 1900 1905

Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser

1910 1915 1920

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn

1925 1930 1935

Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr

1940 1945 1950

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val

1955 1960 1965

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile

1970 1975 1980

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp

1985 1990 1995

Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val

2015 2020 2025

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2030 2035 2040

Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys

2045 2050 2055

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser

2060 2065 2070

Lys Ala Val Thr Gly Leu Gln Thr Ile Asp Ser Lys Lys Tyr Tyr

2075 2080 2085

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile

2090 2095 2100

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala

2105 2110 2115

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr

2120 2125 2130

Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys

2135 2140 2145

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe

2150 2155 2160

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp

2165 2170 2175

Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe

2180 2185 2190

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys

2195 2200 2205

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn

2225 2230 2235

Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly

2240 2245 2250

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn

2255 2260 2265

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe

2270 2275 2280

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly

2285 2290 2295

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys

2300 2305 2310

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln

2315 2320 2325

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu

2330 2335 2340

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe

2345 2350 2355

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp

2360 2365 2370

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr

2375 2380 2385

Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp

2390 2395 2400

Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu

2405 2410 2415

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln

2420 2425 2430

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys

2435 2440 2445

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr

2450 2455 2460

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala

2465 2470 2475

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn

2480 2485 2490

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly

2495 2500 2505

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val

2510 2515 2520

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr

2525 2530 2535

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg

2540 2545 2550

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser

2555 2560 2565

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr

2570 2575 2580

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile

2585 2590 2595

Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly

2600 2605 2610

Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn

2615 2620 2625

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn

2630 2635 2640

Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn

2645 2650 2655

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr

2660 2665 2670

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe

2675 2680 2685

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys

2690 2695 2700

Ala Pro Gly Ile Tyr Gly

2705

<210> 712

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 712

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Val

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys Asp

705 710 715 720

Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu

1115 1120 1125

Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn

1325 1330 1335

Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Ser

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys Pro

1490 1495 1500

Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys Ile

1715 1720 1725

Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly Asn

1760 1765 1770

Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile

1835 1840 1845

Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr

1865 1870 1875

Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly

1925 1930 1935

Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu

1940 1945 1950

Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile

2090 2095 2100

Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp Gly

2255 2260 2265

Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe Tyr

2270 2275 2280

Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 713

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 713

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 714

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 714

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Val

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys Asp

705 710 715 720

Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu

1115 1120 1125

Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn

1325 1330 1335

Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Ser

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys Pro

1490 1495 1500

Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys Ile

1715 1720 1725

Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly Asn

1760 1765 1770

Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile

1835 1840 1845

Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr

1865 1870 1875

Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly

1925 1930 1935

Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu

1940 1945 1950

Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile

2090 2095 2100

Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp Gly

2255 2260 2265

Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe Tyr

2270 2275 2280

Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 715

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 715

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 716

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 716

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Arg Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 717

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 717

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 718

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 718

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 719

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 719

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 720

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 720

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 721

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 721

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Val

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys Asp

705 710 715 720

Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu

1115 1120 1125

Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn

1325 1330 1335

Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Ser

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys Pro

1490 1495 1500

Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys Ile

1715 1720 1725

Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly Asn

1760 1765 1770

Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile

1835 1840 1845

Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr

1865 1870 1875

Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly

1925 1930 1935

Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu

1940 1945 1950

Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile

2090 2095 2100

Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp Gly

2255 2260 2265

Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe Tyr

2270 2275 2280

Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 722

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 722

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Asp Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 723

<211> 2366

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 723

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Ile

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys His Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Thr Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg Gly

565 570 575

Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Thr

610 615 620

Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Ala

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Ser Glu Ile Glu Thr Ala Ile Gly Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Met Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Val

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 724

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 724

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 725

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 725

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 726

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 726

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 727

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 727

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 728

<211> 2366

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 728

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Ile Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg Gly

565 570 575

Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Thr

610 615 620

Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Leu Ile Gly His Gly Lys Ala

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Ser Glu Ile Glu Thr Ile Ile Asp Leu Ala Lys Ala Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser

1115 1120 1125

Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Lys Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Gly Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Gly Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Gln Tyr Glu Gly Gln Phe Tyr

1250 1255 1260

Trp Arg Phe Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Val Arg Ile Ser Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu

1325 1330 1335

Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Ser Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Ser Asp Val Val Leu Ile Ile Lys Val Tyr Met Asp Asn Ser Lys

1490 1495 1500

Pro Pro Phe Gly Tyr Tyr Ser Asn Asp Leu Lys Asp Val Lys Ala

1505 1510 1515

Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Lys Asn

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Ile Lys Ser Leu Lys Ser Asn Ala Lys Leu Ile Leu Asp Thr

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys

1715 1720 1725

Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly

1760 1765 1770

Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Ser Ile Asn Lys Ile Ile Ser Thr Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Val Glu Gly Leu Leu Asn Tyr His Leu Gly Leu Ile Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu

1865 1870 1875

Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Pro Asn Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Val Tyr Tyr Phe

1925 1930 1935

Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp

1940 1945 1950

Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Ser Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Thr

2090 2095 2100

Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln

2105 2110 2115

Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp

2255 2260 2265

Gly Ile Met Gln Tyr Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Asn Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Ala Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Ile

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Glu Leu Val Ile Ser Glu

2360 2365

<210> 729

<211> 2366

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 729

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Ile Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg Gly

565 570 575

Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Thr

610 615 620

Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Leu Ile Gly His Gly Lys Ala

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Ser Glu Ile Glu Thr Ile Ile Asp Leu Ala Lys Ala Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser

1115 1120 1125

Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Lys Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Gly Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Gly Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Gln Tyr Glu Gly Gln Phe Tyr

1250 1255 1260

Trp Arg Phe Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Val Arg Ile Ser Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu

1325 1330 1335

Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Ser Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Ser Asp Val Val Leu Ile Ile Lys Val Tyr Met Asp Asn Ser Lys

1490 1495 1500

Pro Pro Phe Gly Tyr Tyr Ser Asn Asp Leu Lys Asp Val Lys Ala

1505 1510 1515

Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Lys Asn

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Ile Lys Ser Leu Lys Ser Asn Ala Lys Leu Ile Leu Asp Thr

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys

1715 1720 1725

Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly

1760 1765 1770

Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Ser Ile Asn Lys Ile Ile Ser Thr Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Val Glu Gly Leu Leu Asn Tyr His Leu Gly Leu Ile Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu

1865 1870 1875

Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Pro Asn Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Val Tyr Tyr Phe

1925 1930 1935

Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp

1940 1945 1950

Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Ser Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Thr

2090 2095 2100

Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln

2105 2110 2115

Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp

2255 2260 2265

Gly Ile Met Gln Tyr Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Asn Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Ala Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Ile

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Glu Leu Val Ile Ser Glu

2360 2365

<210> 730

<211> 2366

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 730

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Ile Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg Gly

565 570 575

Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Thr

610 615 620

Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Leu Ile Gly His Gly Lys Ala

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Ser Glu Ile Glu Thr Ile Ile Asp Leu Ala Lys Ala Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser

1115 1120 1125

Leu Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ser Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Lys Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Gly Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Gly Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Gln Tyr Glu Gly Gln Phe Tyr

1250 1255 1260

Trp Arg Phe Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Val Arg Ile Ser Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu

1325 1330 1335

Asn Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Ser Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile

1370 1375 1380

Leu Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Cys Ser Thr Lys Asp Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Ser Asp Val Val Leu Ile Ile Lys Val Tyr Met Asp Asn Ser Lys

1490 1495 1500

Pro Pro Phe Gly Tyr Tyr Ser Asn Asp Leu Lys Asp Val Lys Ala

1505 1510 1515

Ile Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Lys Asn

1535 1540 1545

Thr Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Ile Lys Ser Leu Lys Ser Asn Ala Lys Leu Ile Leu Asp Thr

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys

1715 1720 1725

Ile Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly

1760 1765 1770

Asn Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Ser Ile Asn Lys Ile Ile Ser Thr Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Val Glu Gly Leu Leu Asn Tyr His Leu Gly Leu Ile Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Ile Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu

1865 1870 1875

Thr Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Pro Asn Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Val Tyr Tyr Phe

1925 1930 1935

Gly Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp

1940 1945 1950

Glu Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Ile Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Ser Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Thr

2090 2095 2100

Ile Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln

2105 2110 2115

Ile Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp

2255 2260 2265

Gly Ile Met Gln Tyr Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Asn Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Ala Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Ile

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Glu Leu Val Ile Ser Glu

2360 2365

<210> 731

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 731

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 732

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 732

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 733

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 733

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Leu Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 734

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 734

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 735

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 735

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr Gln

180 185 190

Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Val

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys Asp

705 710 715 720

Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Ser His Ile Ser Leu

1115 1120 1125

Ala Glu Ser Glu Gly Ala Phe Thr Ser Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Thr Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Val Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Asn Ile Asn Ile Glu Leu Asn

1325 1330 1335

Glu Asn Asp Thr Trp Val Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Asn Ile Leu Ser Lys Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asp Asn His Glu Ile Asn Phe Ser Gly Thr Leu Asn Gly Gly Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Val Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Val Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Thr Leu Met Ala Asn Ser Asn Ser Val Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Leu Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Met Asp Asp Lys Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Cys Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Ser

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asn Ser Lys Pro

1490 1495 1500

Leu Phe Gly Tyr Cys Ser Asn Asp Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asp Val Ile Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Ile Gln Asp Glu Asn Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val Tyr Leu Asp Glu Asn Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Ile Asn Ser Leu Gln Ser Asn Thr Lys Leu Ile Leu Asp Thr Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Lys Asp Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Lys Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Ile Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Ile Tyr Glu Ala Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Thr Asn Tyr Ile Ser Glu Lys Ile

1715 1720 1725

Asn Ile Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Ser Asp Phe Ile Leu Met Ser Thr Asp Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Thr Asn Val Phe Lys Gly Asn

1760 1765 1770

Thr Ile Ser Asp Lys Ile Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Ser Ile Asn Lys Val Ile Ser Thr Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Val Glu Gly Leu Leu Asn Tyr Asp Leu Gly Leu Ile Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Val Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Ile

1835 1840 1845

Lys Asn Leu Ile Thr Gly Phe Thr Thr Ile Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Asp Asn Gly Gly Ala Ala Ser Val Gly Glu Thr

1865 1870 1875

Ile Ile Asp Gly Lys Asn Tyr Tyr Phe Ser Gln Asn Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asp Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Thr Ile Asp Glu Asn Val Tyr Tyr Phe Gly

1925 1930 1935

Asp Asn Tyr Arg Ala Ala Ile Glu Trp Gln Thr Leu Asp Asp Glu

1940 1945 1950

Val Tyr Tyr Phe Ser Thr Asp Thr Gly Arg Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Phe Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Asn Ile Asn Asp Lys Thr Phe Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Ser Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ala Asp Gly Phe Lys Tyr Phe Ala His His Asp Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Leu Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Ile Ser Ile Ile

2090 2095 2100

Asn Asp Gly Lys Tyr Tyr Phe Asn Asp Ser Gly Ile Met Gln Ile

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Glu Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Val Glu Ser Gly Met Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Asn Gly Leu Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asp Pro Glu Thr Lys Lys Ala Tyr Lys Gly Ile Asn Val Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Thr Phe Glu Asp Asn His Tyr Tyr Phe Asn Glu Asp Gly

2255 2260 2265

Ile Met Gln Tyr Gly Tyr Leu Asn Ile Glu Asp Lys Thr Phe Tyr

2270 2275 2280

Phe Ser Glu Asp Gly Ile Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 736

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 736

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 737

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 737

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 738

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 738

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 739

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 739

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 740

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 740

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 741

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 741

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 742

<211> 2366

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 742

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Ile

65 70 75 80

Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met Gln

165 170 175

Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu Arg

260 265 270

Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro Asp

290 295 300

Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala Ile

305 310 315 320

Met Lys His Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe Asp

325 330 335

Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser

340 345 350

Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu Val

355 360 365

Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile Asn

370 375 380

Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu Ile

385 390 395 400

Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly Pro

405 410 415

Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe Gly

420 425 430

Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile Ala

435 440 445

Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn Thr

450 455 460

Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys Asp

465 470 475 480

Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser Ser

485 490 495

Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala Thr

500 505 510

Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Glu Arg Ala Lys

515 520 525

Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu Gly

530 535 540

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Thr Asp Lys Glu

545 550 555 560

Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg Gly

565 570 575

Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu

580 585 590

Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu Phe

595 600 605

Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Thr

610 615 620

Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg Ile

625 630 635 640

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Ala

645 650 655

Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser

660 665 670

Ser Glu Ile Glu Thr Ala Ile Gly Leu Ala Lys Glu Asp Ile Ser Pro

675 680 685

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser

690 695 700

Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys

705 710 715 720

Asp Lys Val Ser Glu Leu Met Pro Ser Met Ser Gln Asp Ser Ile Ile

725 730 735

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg

740 745 750

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile

755 760 765

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu

770 775 780

Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu

785 790 795 800

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu

805 810 815

Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile

820 825 830

Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu Thr

835 840 845

Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser

850 855 860

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp

865 870 875 880

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe

885 890 895

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu

900 905 910

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu

915 920 925

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu

930 935 940

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn

945 950 955 960

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Ser Lys Glu

965 970 975

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln

980 985 990

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val

995 1000 1005

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro

1010 1015 1020

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly

1025 1030 1035

Val Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp

1040 1045 1050

Pro Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala

1055 1060 1065

Val Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu

1070 1075 1080

Gly Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly

1085 1090 1095

Ile Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu

1100 1105 1110

Arg Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser

1115 1120 1125

Leu Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Val

1130 1135 1140

Met Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn

1145 1150 1155

Asn Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu

1160 1165 1170

Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe

1175 1180 1185

Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr

1190 1195 1200

Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp

1205 1210 1215

Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu

1220 1225 1230

Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr

1235 1240 1245

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr

1250 1255 1260

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Leu

1265 1270 1275

Lys Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser

1280 1285 1290

Asn Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile

1295 1300 1305

Arg Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr

1310 1315 1320

Ala Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu

1325 1330 1335

Ser Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg

1340 1345 1350

Asp Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile

1355 1360 1365

Glu Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile

1370 1375 1380

Leu Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser

1385 1390 1395

Asn Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn

1400 1405 1410

Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu

1415 1420 1425

Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile

1430 1435 1440

Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys

1445 1450 1455

Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly

1460 1465 1470

Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu

1475 1480 1485

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys

1490 1495 1500

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val

1505 1510 1515

Ile Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys

1520 1525 1530

Asp Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys

1535 1540 1545

Thr Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala

1550 1555 1560

Glu Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser

1565 1570 1575

Asp Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile

1580 1585 1590

Phe Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala

1595 1600 1605

Asn Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe

1610 1615 1620

Ile Cys Asp Glu Asn Asn Asn Ile Gln Pro Tyr Phe Ile Lys Phe

1625 1630 1635

Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln

1640 1645 1650

Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp

1655 1660 1665

Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly

1670 1675 1680

Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr

1685 1690 1695

Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr

1700 1705 1710

Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys

1715 1720 1725

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser

1730 1735 1740

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn

1745 1750 1755

Lys Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp

1760 1765 1770

Lys Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln

1775 1780 1785

Asp Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr

1790 1795 1800

Tyr Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu

1805 1810 1815

Tyr Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser

1820 1825 1830

Gly Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro

1835 1840 1845

Val Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys

1850 1855 1860

Tyr Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu

1865 1870 1875

Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val

1880 1885 1890

Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe

1895 1900 1905

Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile

1910 1915 1920

Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe

1925 1930 1935

Glu Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly

1940 1945 1950

Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly

1955 1960 1965

Leu Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly

1970 1975 1980

Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr

1985 1990 1995

Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp

2000 2005 2010

Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly

2015 2020 2025

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn

2030 2035 2040

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly

2045 2050 2055

Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe

2060 2065 2070

Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr

2075 2080 2085

Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu

2090 2095 2100

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln

2105 2110 2115

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp

2120 2125 2130

Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr

2135 2140 2145

Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp

2150 2155 2160

Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn

2165 2170 2175

Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg

2180 2185 2190

Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu

2195 2200 2205

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr

2210 2215 2220

Phe Asp Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile

2225 2230 2235

Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr

2240 2245 2250

Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn

2255 2260 2265

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe

2270 2275 2280

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr

2285 2290 2295

Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu

2300 2305 2310

Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu

2315 2320 2325

Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr

2330 2335 2340

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp

2345 2350 2355

Thr Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 743

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 743

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 744

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 744

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 745

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 745

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 746

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 746

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 747

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 747

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Phe Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ser Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 748

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 748

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 749

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 749

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Glu Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 750

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 750

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 751

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 751

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 752

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 752

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 753

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 753

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 754

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 754

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 755

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 755

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 756

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 756

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 757

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 757

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 758

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 758

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 759

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 759

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Arg Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 760

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 760

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Ile

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Ile

130 135 140

Val Glu Ser Ala Ile Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Gly Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys Val

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Arg Gly Glu Ile

915 920 925

Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Val Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Ala Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Val Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Ile Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Ala Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Ile Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asn Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ser Pro Thr Ile Thr Tyr Ile Lys Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Glu Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp His Tyr Lys Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Asn Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu His Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe His Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Asp Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Asp Asn Lys Ile Ile Leu

1370 1375 1380

Asn His His Glu Ile Asn Phe Ser Gly Asp Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Ile Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Phe Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Gly Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Lys Lys Gly Ser Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Val Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Lys Ile Asn Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Thr Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Asn Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Ser Ala Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Thr Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asn Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Ile Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Leu Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Glu

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met Tyr Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Asp Lys Tyr Tyr Phe Asn Ser Asp Gly Ile

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Lys Lys Tyr Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Ile Glu Ile Asp Gly

2000 2005 2010

Lys Tyr Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Ser Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Ala Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Tyr Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Val Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asn Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Glu Lys Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Glu Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Asp Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Ile Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Asn Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asp Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Gln

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

<210> 761

<211> 2365

<212> PROTEIN

<213> Artificial sequence

<220>

<223> Synthetic amino acid sequence

<400> 761

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe

1 5 10 15

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu

20 25 30

Tyr His Asn Met Ser Glu Asn Thr Val Glu Lys Tyr Leu Lys Leu

35 40 45

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys

50 55 60

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr

65 70 75 80

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn

85 90 95

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn

100 105 110

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val

115 120 125

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val

130 135 140

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu

145 150 155 160

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu

165 170 175

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln

180 185 190

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr

195 200 205

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile

210 215 220

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg

225 230 235 240

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln

245 250 255

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg

260 265 270

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met

275 280 285

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser

290 295 300

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met

305 310 315 320

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met

325 330 335

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys

340 345 350

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser

355 360 365

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln

370 375 380

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys

385 390 395 400

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala

405 410 415

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp

420 425 430

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu

435 440 445

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr

450 455 460

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu

465 470 475 480

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp

485 490 495

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu

500 505 510

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala

515 520 525

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu

530 535 540

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr

545 550 555 560

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr

565 570 575

Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala

580 585 590

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln

595 600 605

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp

610 615 620

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser

625 630 635 640

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu

645 650 655

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr

660 665 670

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys

675 680 685

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile

690 695 700

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp

705 710 715 720

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val

725 730 735

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu

740 745 750

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile

755 760 765

Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn

770 775 780

Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu

785 790 795 800

Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu

805 810 815

Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp

820 825 830

Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser

835 840 845

Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile

850 855 860

Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser

865 870 875 880

His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser

885 890 895

Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr

900 905 910

Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile

915 920 925

Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val

930 935 940

Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala

945 950 955 960

Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser

965 970 975

Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu

980 985 990

Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val Glu

995 1000 1005

Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr

1010 1015 1020

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val

1025 1030 1035

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro

1040 1045 1050

Leu Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val

1055 1060 1065

Asn Leu Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly

1070 1075 1080

Ile Ala Ser Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile

1085 1090 1095

Ser Ala Gly Ile Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg

1100 1105 1110

Asp Lys Ala Thr Lys Val Val Asp Tyr Phe Lys His Val Ser Leu

1115 1120 1125

Val Glu Thr Glu Gly Val Phe Thr Leu Leu Asp Asp Lys Ile Met

1130 1135 1140

Met Pro Gln Asp Asp Leu Val Ile Ser Glu Ile Asp Phe Asn Asn

1145 1150 1155

Asn Ser Ile Val Leu Gly Lys Cys Glu Ile Trp Arg Met Glu Gly

1160 1165 1170

Gly Ser Gly His Thr Val Thr Asp Asp Ile Asp His Phe Phe Ser

1175 1180 1185

Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu Ser Ile Tyr Asp

1190 1195 1200

Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser Lys Asp Leu

1205 1210 1215

Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp Glu Thr

1220 1225 1230

Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr Lys

1235 1240 1245

Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp

1250 1255 1260

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys

1265 1270 1275

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn

1280 1285 1290

Thr Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg

1295 1300 1305

Glu Lys Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala

1310 1315 1320

Leu Ser Leu Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser

1325 1330 1335

Glu Ser Asp Val Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp

1340 1345 1350

Val Thr Ile Glu Ser Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu

1355 1360 1365

Gly Ile Leu Ser Thr Leu Ser Ile Glu Glu Asn Lys Ile Ile Leu

1370 1375 1380

Asn Ser His Glu Ile Asn Phe Ser Gly Glu Val Asn Gly Ser Asn

1385 1390 1395

Gly Phe Val Ser Leu Thr Phe Ser Ile Leu Glu Gly Ile Asn Ala

1400 1405 1410

Ile Ile Glu Val Asp Leu Leu Ser Lys Ser Tyr Lys Leu Leu Ile

1415 1420 1425

Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser Asn His Ile Gln

1430 1435 1440

Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu Gln Lys Asn

1445 1450 1455

Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn Gly Phe

1460 1465 1470

Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu Pro

1475 1480 1485

Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro

1490 1495 1500

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile

1505 1510 1515

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp

1520 1525 1530

Asp Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr

1535 1540 1545

Ile Lys Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu

1550 1555 1560

Ile Leu Lys Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp

1565 1570 1575

Ser Leu Met Ser Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe

1580 1585 1590

Val Asn Phe Leu Gln Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn

1595 1600 1605

Phe Ile Ile Ser Gly Thr Thr Ser Ile Gly Gln Phe Glu Phe Ile

1610 1615 1620

Cys Asp Glu Asn Asp Asn Ile Gln Pro Tyr Phe Ile Lys Phe Asn

1625 1630 1635

Thr Leu Glu Thr Asn Tyr Thr Leu Tyr Val Gly Asn Arg Gln Asn

1640 1645 1650

Met Ile Val Glu Pro Asn Tyr Asp Leu Asp Asp Ser Gly Asp Ile

1655 1660 1665

Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr Leu Tyr Gly Ile

1670 1675 1680

Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn Ile Tyr Thr

1685 1690 1695

Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn Thr Tyr

1700 1705 1710

Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys Ile

1715 1720 1725

Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn

1730 1735 1740

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys

1745 1750 1755

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys

1760 1765 1770

Thr Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp

1775 1780 1785

Val Pro Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr

1790 1795 1800

Glu Asp Gly Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr

1805 1810 1815

Asn Glu Lys Phe Tyr Ile Asn Asn Phe Gly Met Met Val Ser Gly

1820 1825 1830

Leu Ile Tyr Ile Asn Asp Ser Leu Tyr Tyr Phe Lys Pro Pro Val

1835 1840 1845

Asn Asn Leu Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr

1850 1855 1860

Tyr Phe Asn Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr

1865 1870 1875

Ile Ile Asp Asp Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu

1880 1885 1890

Gln Thr Gly Val Phe Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala

1895 1900 1905

Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly Glu Ala Ile Asp

1910 1915 1920

Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr Tyr Phe Asp

1925 1930 1935

Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp Gly Glu

1940 1945 1950

Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly Leu

1955 1960 1965

Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val

1970 1975 1980

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe

1985 1990 1995

Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly

2000 2005 2010

Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val

2015 2020 2025

Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu

2030 2035 2040

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile

2045 2050 2055

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr

2060 2065 2070

Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr

2075 2080 2085

Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile

2090 2095 2100

Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val

2105 2110 2115

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser

2120 2125 2130

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe

2135 2140 2145

Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr

2150 2155 2160

Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp

2165 2170 2175

Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val

2180 2185 2190

Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr

2195 2200 2205

Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe

2210 2215 2220

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp

2225 2230 2235

Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly

2240 2245 2250

Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly

2255 2260 2265

Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr

2270 2275 2280

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro

2285 2290 2295

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn

2300 2305 2310

Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp

2315 2320 2325

Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly

2330 2335 2340

Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr

2345 2350 2355

Ala Gln Leu Val Ile Ser Glu

2360 2365

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Claims (27)

1. A method of inducing an immune response in a human against Clostridium difficile infection, comprising administering to a human an effective dose of a composition containing a C. difficile toxoid having the amino acid sequence of SEQ ID NO: 4, where the parent methionine is absent, and a C. difficile toxoid having the amino acid sequence of SEQ ID NO: 6, where the original methionine is absent, while the composition is administered at least three times, with the second administration occurring approximately 30 days after the first administration and the third administration approximately 180 days after the first administration, and the immune response against difficile toxin A and toxin B of C. difficile persist for at least about 60 days, with the composition resulting in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in humans after the third dose than the concentration of specific to toxin B neutralizing antibodies in a person receiving a third dose approximately 30 days after the first dose, when measured under identical conditions in the cytotoxicity assay. 2. The method of claim 1, wherein the immune response elicited comprises a neutralizing monoclonal antibody against toxin A. 3. The method of claim 1, wherein the immune response elicited comprises a neutralizing monoclonal antibody against toxin B. 4. The method of claim 1, wherein the immune response elicited comprises a neutralizing monoclonal antibody against toxin A and a neutralizing monoclonal antibody against toxin B, wherein the concentration of the neutralizing monoclonal antibody is at least 10 µg/mL. 5. The method of claim 1, wherein the composition comprises C. difficile toxoid A and/or C. difficile toxoid B, each of which is at least 90% or more pure. 6. The method of claim 1 wherein the composition comprises C. difficile toxoid A and/or C. difficile toxoid B in a ratio of about 3:1 to about 1:1. 7. The method according to claim 1, characterized in that the composition contains C. difficile toxoid A and/or C. difficile toxoid B in a ratio of 1:1. 8. The method according to p. 1, characterized in that the composition contains an adjuvant. 9. The method according to p. 1, characterized in that the composition contains an aluminum-based adjuvant. 10. The method of claim 1, wherein the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 180 days. 11. The method of claim 1, wherein the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 365 days. 12. The method of claim 1, wherein the immune response against C. difficile toxin A and/or B toxin is maintained for at least about 540 days. 13. The method of claim 1, wherein C. difficile toxoid A and C. difficile toxoid B are lyophilized. 14. The method of claim 1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the first dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose. , when measured under identical conditions in the cytotoxicity assay. 15. The method of claim 1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the first dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose. , when measured under identical conditions in the cytotoxicity assay. 16. The method of claim 1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the first dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose. , when measured under identical conditions in the cytotoxicity assay. 17. The method of claim 1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the first dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose. , when measured under identical conditions in the cytotoxicity assay. 18. The method of claim 1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the second dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose. , when measured under identical conditions in the cytotoxicity assay. 19. The method of claim 1, wherein the composition results in a toxin A-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the second dose than the toxin A-specific neutralizing antibody concentration in the human prior to the first dose. , when measured under identical conditions in the cytotoxicity assay. 20. The method of claim 1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 2-fold higher in the human after the second dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose. , when measured under identical conditions in the cytotoxicity assay. 21. The method of claim 1, wherein the composition results in a toxin B-specific neutralizing antibody concentration that is at least 32-fold higher in the human after the second dose than the toxin B-specific neutralizing antibody concentration in the human prior to the first dose. , when measured under identical conditions in the cytotoxicity assay. 22. The method of claim 1, wherein the individual is seronegative for toxin B. 23. The method of claim 1, wherein the individual is seronegative for toxin A. 24. The method of claim 1, wherein the individual is seronegative for toxin A and toxin B. 25. The method of claim 1, wherein the individual is seropositive for toxin B. 26. The method of claim 1, wherein the individual is seropositive for toxin A. 27. The method of claim 1, wherein the individual is seropositive for toxin A and toxin B.

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