RU2768572C1 - Personal evaporation device - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to medical equipment, namely to a cartridge with a starting material for delivering an active substance by inhalation. Cartridge contains an elongated body containing sections located along the long axis of the said body. Each of the sections contains a starting material containing an active substance capable of being released from the starting material during evaporation. Initial material is intended to provide a through air flow. Initial material in each of the sections is protected by an airtight sealant. Cartridge has a drive installed in a sliding manner on the elongated body. Drive is made with possibility of sliding along part of long axis of said housing between areas of selected sections. Actuator is made with possibility of local opening of sealant of selected sections to provide air flow through initial material for delivery of specified active substance to user. Drive is additionally designed to pass electric current through the heating element of each of the selected sections.

EFFECT: delivery of an active substance for a number of delivery events, in which a controlled portion of the starting material is heated independently of other portions of the starting material.

20 cl, 31 dwg

Description

RELATED APPLICATION

This application claims the benefit of priority under the provisions of 35 USC §119(e), US Provisional Application No. 62/277,060, filed January 11, 2016, the contents of which are hereby incorporated by reference in their entirety.

FIELD OF TECHNOLOGY AND BACKGROUND OF THE INVENTION

The present invention, in some embodiments, relates to the delivery of an active agent via inhalation, and more particularly, but not exclusively, to the delivery of at least one active agent through a plurality of delivery events in which a controlled portion of the source material is heated independently of other portions of the source material. .

DISCLOSURE OF THE INVENTION

According to one aspect of some embodiments of the invention, a device is provided for releasing at least one substance from a source material and comprising: a housing; some set of sections with the source material, located in fixed places relative to the housing; a plurality of airflow channels, each airflow channel associated with at least one of the source material sections, and each airflow channel associated with at least one blocking element that prevents the passage of airflow through the channel; and an actuator connected to the blocking element to operate the latter, the actuator being adapted to unblock the air flow path associated with at least one selected feed section to allow air flow to and through the feed material in that section. In some embodiments, each feed section is associated with a separate heating element. In some embodiments, the implementation of the heating element is designed to heat the source material to release at least one active agent. In some embodiments, the drive is designed to be electrically coupled to a heating element associated with a selected feed section. In some embodiments, the device is configured such that air that passes through the selected feed section does not affect unselected sections. In some embodiments, the device includes a controller programmed to coordinate between the flow of air passing through at least one section of the source material, and the inclusion of a heating element associated with at least one section of the source material. In some embodiments, the implementation of the device is designed so that you can use the sections with the source material in an order that is independent of the spatial arrangement of the sections with the source material. In some embodiments, the implementation of the blocking element includes a cover of the section with the source material. In some embodiments, the actuator is configured to slide the lid into a position where airflow can flow to and through the feedstock in the section. In some embodiments, the actuator is configured to move the lid by magnetic attraction. In some embodiments, the implementation of the device includes a mouthpiece and at least one channel for directing the flow of air through the heated section with the source material and to the mouthpiece. In some embodiments, a plurality of feed sections are arranged linearly along the long axis, and the actuator can move along the long axis. In some embodiments, the device is an inhaler designed to deliver at least one active agent to a user via inhalation. In some embodiments, the device is designed to deliver at least one active agent over a plurality of delivery events, with a controlled dose of the active agent being delivered to the user in each delivery event. In some embodiments, the device is a cartridge for use with an inhalation device. In some embodiments, the feed sections are separated from one another by an airtight barrier. In some embodiments, the implementation of the device includes at least one shared channel, passing along the sections with the source material. In some embodiments, the implementation of the source material in at least one of the sections includes nicotine in the amount of 1-10%. In some embodiments, the source material layer in each section is no more than 1 mm thick. In some embodiments, different feed sections include different feeds. In some embodiments, the implementation of the sections with the source material include different active substances or their compositions. In some embodiments, the implementation of the sections with the source material are linear relative to each other. In some embodiments, the amount of active substance decreases along the long axis defined by the group of sections. In some embodiments, the amount of active substance increases along the long axis defined by the group of sections.

According to one aspect of some embodiments of the invention, a device is provided for delivering by inhalation at least one active substance released from a source material, the device comprising: one or more sections with the source material, in which the source material is protected by an air-tight sealant, moreover, the sealant includes a control area that serves to locate at least one through hole in the sealant; a duct structure for directing airflow to a user of the device through one or more sections; and an actuator aligned with the sealant control portion and a channeling pattern for selectively opening at least one through hole in the sealant on the sections to allow air to pass through the parent material. In some embodiments, the control area of the sealant is temperature sensitive, and the actuator includes a heating element for heating the sealant to open at least one hole. In some embodiments, the actuator includes an air element for applying inhalation pressure to the sealant control site to open at least one opening. In some embodiments, the actuator includes an array of electrodes for delivering electricity to the sealant control area to open at least one opening. In some embodiments, the drive includes a knife or punch for perforating a test area of the sealant to expose at least one hole. In some embodiments, the implementation of the device includes a power source. In some embodiments, the actuator may move relative to one or more feed sections. In some embodiments, the drive is slidable, rolling, and/or draggable relative to the feed sections. In some embodiments, the device includes a progress indicator designed to indicate one or more of: the number of source material sections used, the number of source material sections remaining, the amount of source material remaining in the section, that all source material sections have been consumed, and that a certain part of the sections with the source material was used. In some embodiments, the implementation of the device has an elongated shape, and the progress indicator can move at least part of the length of the device. In some embodiments, the longitudinal position of the progress indicator corresponds to the sequential position of the source material section currently in use. In some embodiments, the progress indicator may move when a new section of source material is downloaded, the download being performed automatically and/or manually by the user. In some embodiments, the progress indicator includes one or more of a light indication and a color indication. In some embodiments, the source material sections are located in a cartridge that is inserted into the inhaler. In some embodiments, multiple feed cartridges are installed in the inhaler.

According to one aspect of some embodiments of the invention, there is provided a feed cartridge for use with an inhalation device and comprising: one or more sections comprising a feed, wherein the feed comprises at least one volatilized active, and the feed is located so as to pass a stream of air through it; wherein the parent material is protected by an air-tight sealant, wherein the sealant includes a control area that is sensitive to mechanical stress and/or temperature and serves to make at least one through hole in the sealant during use of the inhaler device to allow air to pass through the original the material of one or more selected sections for delivering at least one active substance to the user. In some embodiments, the implementation of the sealant is designed to open at least one hole as a result of heating. In some embodiments, the implementation of the sealant is designed to heat the source material. In some embodiments, the cartridge includes only one section of the source material, made in the form of an elongated tray, and the amount of active substance released from at least part of the tray is determined by adjusting the air flow into this part. In some embodiments, the cartridge includes a plurality of feed sections that are separated from one another by at least one of thermal insulation and electrical insulation. In some embodiments, the cartridge includes one or more channels through which drug-laden air flows for delivery to the user such that once the cartridge is installed in the inhaler, the drug-laden air flows only through the cartridge, thereby eliminating the possibility of residue build-up in the inhaler.

According to one aspect of some embodiments of the invention, a device is provided for delivering to a user at least one substance released from a source material, and comprising: a scaffold comprising one or more sections with source material; a mouthpiece and a channel for supplying a substance through at least one of the sections to the user, while the channel passes between at least one of the sections with the source material and the mouthpiece. In some embodiments, the frame is shaped and sized so that it can be connected to an inhaler device. In some embodiments, the implementation of at least one section with the source material and the channel is sealed, so that the air flow can only pass through this at least one section and the channel.

According to one aspect of some embodiments of the invention, a device is provided for delivering by inhalation at least one active substance released from a source material, and including: a substrate including a plurality of grooves, where each groove contains the source material and is associated with a separate channel for the flow air; a movable actuator positioned to unlock the airflow passage after aligning with the airflow passage opening to direct airflow through the parent material in at least one selected slot. In some embodiments, the apparatus also includes a heating element associated with each of the feed slots and circuitry for electrically connecting the heating element to a power source while the drive is moving. In some embodiments, the actuator rotates. In some embodiments, the implementation of the substrate includes a printed circuit board.

According to one aspect of some embodiments of the invention, an inhalation device is provided for delivering to a user at least one substance released from a source material, and comprising: one or more sections with source material located along a longitudinal axis; a movable drive designed for automatic or manual movement along the longitudinal axis to ensure the release of at least one substance from at least one section with the source material. In some embodiments, the implementation of the movable actuator is designed to unblock at least one channel for air flow associated with at least one section of the source material. In some embodiments, the implementation of the movable actuator is designed to turn on the heating element associated with at least one section of the source material.

According to one aspect of some embodiments of the invention, there is provided a feed cartridge comprising: one or more sealed sections containing feed; a transport channel for directing the flow of air into at least one non-sealed section with the source material; and a bypass channel that does not pass through the sections with the source material; while the flow through the bypass channel is regulated in accordance with the flow through the transport channel.

According to one aspect of some embodiments, an inhalation device is provided for delivering at least one substance released from a source material to a user, which device can accept a plurality of cartridges, each of which includes a plurality of source material sections, and wherein the device includes a controller for addressing at least one source material section of at least one of said plurality of cartridges according to a predetermined mode and for delivering at least one substance released from this at least one source material section to a user. In some embodiments, after a plurality of cartridges are installed in the inhaler, the cartridges remain stationary and do not move relative to each other even during use. In some embodiments, a plurality of feed sections of a single cartridge remain stationary and do not move relative to each other, even during use. In some embodiments, the implementation of the controller is designed to access at least one section of the source material at the request of the user. In some embodiments, a plurality of cartridges contain different starting materials or compositions thereof. In some embodiments, a plurality of feed sections of the same cartridge contain different feeds or compositions thereof.

According to one aspect of some embodiments of the invention, a device is provided for delivering by inhalation at least one active substance released from the source material by evaporation, and the device includes: a receptacle designed to receive at least one cartridge, including one or more sections with source material, in which the source material is protected by a sealant, impervious to air, and the sealant includes a control area that serves to perform at least one through hole in the sealant; a channel structure for directing air flow through one or more selected sections to a user of the device when the cartridge is installed in the receptacle; and an actuator aligned with the sealant control portion and channel structure to open at least one through hole in the sealant in selected sections to allow air to pass through the parent material. In some embodiments, the control area of the sealant is temperature sensitive, and the actuator includes a heating element for heating the sealant to open at least one hole. In some embodiments, the implementation of the heating element is designed to heat the source material to vaporize at least one active agent. In some embodiments, the actuator includes an air element for applying inhalation pressure to the sealant control site to open at least one opening. In some embodiments, the actuator includes an array of electrodes for delivering electricity to the sealant control area to open at least one opening. In some embodiments, the drive includes a knife or punch for perforating a test area of the sealant to expose at least one hole. In some embodiments, the implementation of the device includes a power supply. In some embodiments, the actuator may move relative to one or more cartridge feed sections. In some embodiments, the drive is slidable, rolling, and/or draggable relative to the feed sections. In some embodiments, the device is designed to deliver at least one active agent over a plurality of delivery events, wherein a controlled dose of the active agent is delivered to the user at each delivery event. In some embodiments, the device includes a progress indicator designed to indicate one or more of: the amount of starting material used, the remaining amount of starting material, that all of the starting material has been used up, and that a certain amount of starting material has been used. In some embodiments, the implementation of the device has an elongated shape, and the progress indicator is designed to move along at least part of the length of the device. In some embodiments, the longitudinal position of the progress indicator corresponds to the sequential position of the source material section currently in use. In some embodiments, the progress indicator may move when a new section of source material is downloaded, the download being performed automatically and/or manually by the user. In some embodiments, the progress indicator includes one or more of a light indication and a color indication.

According to one aspect of some embodiments of the invention, there is provided a feed cartridge for use with an evaporator device and comprising one or more feed containing sections, the sections being separated from one another by thermal and/or electrical insulation; the source material includes at least one active substance released upon evaporation; the source material is located so as to pass through it the flow of air; wherein the parent material in each of the sections is protected by an airtight sealant, the sealant including a control area which is mechanically and/or temperature sensitive and serves to make at least one through hole in the sealant during use of the evaporative device to allow air to pass through the source material of one or more selected sections to deliver at least one active substance to the user of the evaporation device. In some embodiments, the implementation of the sealant may be heated to open at least one hole. In some embodiments, the implementation of the sealant is designed to heat the source material. In some embodiments, the sealant is a foil comprising an electrically resistive substance, and the sealant is an electrically conductive foil designed to heat the starting material when an electric current is applied to the foil. In some embodiments, the sealant includes a shape memory material, such as, but not limited to, shape memory polymers, which deform when exposed to heat, thereby exposing the parent material. In some embodiments, one or more springs and/or other mechanisms are used to return the sealant to the closed position when the heating process is complete. Additionally or alternatively, the sealant includes a shape memory material having a bi-directional shape memory effect. In some embodiments, the sealant includes and/or is bonded to a shape memory material such as, but not limited to, shape memory alloys such as nitinol, copper-aluminum-zinc alloy, etc. In some embodiments, the sealant includes stainless steel . In some embodiments, the implementation of the sealant is designed to reseal after use of the original material. In some embodiments, the feed sections are designed to be depressurized in sequential order. In some embodiments, the feed section includes a feed in an amount sufficient to deliver a single dose of active agent after evaporation. In some embodiments, the starting material includes tobacco. In some embodiments, the starting material includes cannabis.

According to one aspect of some embodiments of the invention, there is provided a method for delivering by inhalation at least one active substance released from a starting material by evaporating the starting material, comprising: providing the starting material sealed with an airtight sealant; making at least one hole in the sealant with at least one of heating the sealant and applying a mechanical force to the sealant to allow air to pass through the starting material; directing the flow of air through the source material while heating the source material; delivering vapors of the active substance to the user via inhalation. In some embodiments, the method also includes aligning the actuator to open at least one sealant port with sealant and airflow. In some embodiments, at least one of opening the opening, directing the air flow, and heating begins in response to a user's inhalation. In some embodiments, the implementation of the direction includes dynamic movement on the source material of the element, the design of which allows you to direct the flow of air on the source material.

According to one aspect of some embodiments of the invention, there is provided a feed cartridge for use with an evaporative device, comprising:

a cartridge that includes one or more sections with the source material; mouthpiece; And

a channel designed to direct the flow of vapor, the channel being located between the cartridge and the mouthpiece.

According to one aspect of some embodiments of the invention, a feed cartridge is provided for use with a evaporator device, comprising: a cartridge including one or more feed sections, and a channel designed to direct the flow of vapor, and the channel is designed to be located when used with a evaporator device between the cartridge and the mouthpiece of the device.

According to one aspect of some embodiments of the invention, a device is provided for delivering by inhalation at least one active substance released from the source material by evaporation, and including: a receiving socket designed to receive at least one cartridge, including a plurality of sections with source material ; a heating element designed for separate heating of each of the sections with the source material; and a channel structure adapted to move along the cartridge to selectively direct airflow through one or more feed sections, when those sections are heated, to deliver active agent-laden air to a user via inhalation.

According to one aspect of some embodiments, a method is provided for delivering to a user at least one substance released from a source material, the method comprising: selecting at least one source material section from a plurality of source material sections; creating an air flow channel between the selected source material section and the user outlet so that each source material section is associated with at least one air flow channel. In some embodiments, creating an airflow path includes modifying a state of at least one airflow path associated with at least one selected source material section from a state in which airflow cannot flow through the path to a state in in which at least some of the air flow can pass through the channel. In some embodiments, creating an airflow channel includes unblocking at least one airflow channel. In some embodiments, the airflow channel state modification is reversible. In some embodiments, the method also includes releasing, via air flow, at least one substance from the source material and delivering the air flow, after it has become saturated with the substance, into the user's mouth. In some embodiments, releasing at least one substance includes electrically connecting a heating element associated with at least one feed section to heat the feed in that section. In some embodiments, the time to create an electrical connection is selected in accordance with the time to create a channel for air flow. In some embodiments, a subgroup of at least two source material sections is selected from a plurality of source material sections.

According to one aspect of some embodiments of the invention, there is provided a feed cartridge for use with an inhalation device and comprising: one or more sections containing the starting material, the sections being separated from one another by at least one of thermal insulation and electrical insulation; the source material includes at least one active substance released upon evaporation; the source material is located so as to pass through it the flow of air; and wherein the parent material in each of the sections is protected by an airtight sealant, the sealant including a control area which is mechanically and/or temperature sensitive and serves to make at least one through hole in the sealant during use of the inhaler device so that allow air to pass through the source material of one or more selected sections to deliver at least one active agent to the user. In some embodiments, the implementation of the sealant is designed to open at least one hole as a result of heating. In some embodiments, the implementation of the sealant is designed to heat the source material. In some embodiments, the implementation of the sealant is a foil, including an electrically resistive substance, and the foil is designed to heat the source material when an electric current is applied to the foil. In some embodiments, the implementation of the sealant includes a material with a shape memory. In some embodiments, the implementation of the sealant includes stainless steel. In some embodiments, the implementation of the sealant can be resealed after using the source material.

In some embodiments, the feed sections are arranged so that they can be depressurized in sequential order. In some embodiments, the starting material includes biologically active plant substances. In some embodiments, the starting material includes tobacco. In some embodiments, the starting material includes cannabis.

According to one aspect of some embodiments of the invention, there is provided a method for delivering by inhalation at least one active substance released from a starting material, the method comprising: providing the starting material sealed with an airtight sealant, making at least one of heating the sealant and applying a mechanical force to the sealant to allow air to pass through the parent material, directing air flow through the parent material while heating the parent material, and delivering active agent vapor to the user via inhalation. In some embodiments, the method also includes aligning an actuator for making at least one opening in the sealant with the sealant and airflow. In some embodiments, at least one of opening, directing airflow, and heating is initiated in response to a user's inhalation. In some embodiments, the implementation of the direction includes the dynamic movement of the source material of the element, the design of which allows you to direct the flow of air on the source material.

According to one aspect of some embodiments of the invention, a device is provided for delivering to a user at least one substance released from a source material, and comprising: at least one section of the source material, at least partially sealed with a liquid that changes its viscosity in response to to temperature change; an air flow channel associated with at least one of the feed sections; a heating element for heating said liquid, and one or more chambers into which said liquid can flow when its viscosity is reduced due to heating, thereby exposing at least a portion of the source material to the air flow. In some embodiments, the implementation of the liquid includes silicone oil.

According to one aspect of some embodiments of the invention, there is provided a device for delivering by inhalation at least one active substance released from a source material, the device comprising: a plurality of receptacles for receiving a plurality of cartridges, each cartridge comprising one or more sections with source material; a channel structure for directing air flow through one or more sections towards a user of the device when the cartridges are installed in the receptacles; and a drive for selectively accessing one or more sections of source material based on their contents. In some embodiments, a cartridge selected from a plurality of cartridges includes feed sections that differ in at least one of the amount of active, type of active, type of feed, or composition thereof. In some embodiments, a plurality of cartridges differ from each other in at least one of the amount of active agent, type of active agent, type of starting material, or composition thereof. In some embodiments, the device includes a plurality of feed sections.

According to one aspect of some embodiments of the invention, a device is provided for delivering by inhalation at least one active substance released from the source material by evaporation, and including: a receiving socket designed to receive at least one cartridge, including a plurality of sections with source material ; a heating element designed for separate heating of each of the sections with the source material; and a channel structure adapted to move along the cartridge to selectively direct airflow through one or more feed sections, when those sections are heated, to deliver active agent-laden air to a user via inhalation.

Unless otherwise indicated, all technical and/or scientific terms used herein have the same meaning as generally understood by one of ordinary skill in the art to which the invention pertains. The terms "example" and "such as" as used herein mean "serving as an example, example, or illustration". Any embodiment described as an example should not necessarily be construed as preferable over other embodiments and/or exclude the introduction of features from other embodiments. Although methods and materials similar or equivalent to the methods and materials described herein may be used in practice or to test embodiments of the invention, examples of methods and/or materials are described below. In case of conflict, the description of the invention, including definitions, takes precedence. In addition, the materials, methods, and examples are illustrative only and are not necessarily limiting.

BRIEF DESCRIPTION OF MULTIPLE DRAWING TYPES

Some embodiments of the invention are described herein, but by way of example only, with reference to the accompanying drawings. Now with specific reference to the detailed drawings, it should be emphasized that the details shown are for exemplary purposes only and for purposes of illustrative description of embodiments of the invention. In this regard, the description taken together with the drawings will make it obvious to those skilled in the art how embodiments of the invention may be practiced.

On the drawings:

Fig. 1A is a flow diagram of a general method of operating a device for delivering at least one active agent to a user via inhalation, in accordance with some embodiments of the invention;

Fig. 1B is a schematic view of a device for delivering at least one active agent by inhalation, according to some embodiments of the invention;

Fig. 2A-C are three constructions of the connection between the source material and the heating element according to some embodiments of the invention;

Fig. 3 is a design in which the heating element can move relative to the source material, according to some embodiments of the invention;

Fig. 4A-C illustrate methods and/or structures for dynamically changing the air permeability of a heating element and/or feedstock sealant, in accordance with some embodiments of the invention;

Fig. 5A-B are two flow patterns in which an airflow is directed through a parent material to deliver active agent-laden air to a user, in accordance with some embodiments of the invention;

Fig. 6A-C show mechanisms for moving an air element along a parent material in accordance with some embodiments of the invention;

Fig. 7 is a schematic view of a dynamic air element for directing air through a selected feed section, in accordance with some embodiments of the invention;

Fig. 8A-B illustrate the operation of a device incorporating a plurality of air elements, in accordance with some embodiments of the invention;

Fig. 9 is a schematic view of a heating element and/or sealant designed to allow air flow through the source material section currently being heated and to block flow through the unheated source material sections, in some embodiments;

Fig. 10A-F is a cylindrical cigarette device according to some embodiments of the invention;

Fig. 11A-C are various disposable and/or replaceable components of a device, in accordance with some embodiments of the invention;

Fig. 12A-E are different views of a flat rectangular device, in accordance with some embodiments of the invention;

Fig. 13A-B is an example device shown in FIG. 12A-E including a usage progress indicator, in accordance with some embodiments of the invention;

Fig. 14 is a flow diagram of a general method for delivering at least one substance released from a source material to a user, in accordance with some embodiments of the invention;

Fig. 15A-B is a schematic view of selectively unlocking an airflow channel associated with a selected feed section, in accordance with some embodiments of the invention;

Fig. 16A-B are an arrangement of source material sections for separate access to each of a plurality of source material sections, in accordance with some embodiments of the invention;

Fig. 17A-B is a moving actuator for unblocking at least one airflow channel associated with at least one source material section and/or for turning on a heating element associated with at least one source material section, according to some embodiments of the invention;

Fig. 18A-D are various design features of the drive, as an example of that shown in FIG. 17A-B, according to some embodiments of the invention;

Fig. 19A-B is a cam mechanism for selectively accessing feed sections in sequence, in accordance with some embodiments of the invention;

Fig. 20 - deformable access areas for selective access to one or more sections with the source material, according to some embodiments of the invention;

Fig. 21A-C: mouthpiece (21A and 21B) and frame for use with a group of stock sections (21C), in accordance with some embodiments of the invention;

Fig. 22 is a cross-sectional view of the arrangement of a plurality of feed sections and their respective air passages, in accordance with some embodiments of the invention;

Fig. 23 is an outside view of the arrangement shown as an example in FIG. 22, according to some embodiments of the invention;

Fig. 24A-B are examples of a rotary actuator for use with the arrangement shown as an example in FIG. 22, according to some embodiments of the invention;

Fig. 25A-C is an apparatus including the arrangement shown as an example in FIG. 22, according to some embodiments of the invention;

Fig. 26 is an alternate arrangement of a plurality of feed sections and their corresponding air passages, in accordance with some embodiments of the invention;

Fig. 27A-C are movement of a feed cap using a shape-changing element, in accordance with some embodiments of the invention;

Fig. 28 is an isometric view of an inhaler device with a linear arrangement of separately accessible feed sections, according to some embodiments;

Fig. 29A-B are schematic plan views of an arrangement in which a fluid with varying viscosity is used to seal the feed material, in accordance with some embodiments;

Fig. 30A-B are a schematic view of an inhaler device adapted to receive a plurality of feed cartridges, in accordance with some embodiments; And

Fig. 31A-B are a schematic view of an air flow regime through a device including a plurality of feed sections, in accordance with some embodiments.

DESCRIPTION OF SPECIFIC OPTIONS FOR CARRYING OUT THE INVENTION

The present invention, in some embodiments, relates to the delivery of at least one active agent via inhalation, and more specifically, but not exclusively, to the delivery of at least one active agent over a plurality of delivery events in which a controlled portion of the starting material is heated independently of other parts of the original material.

One aspect of some embodiments relates to an apparatus for heating at least one feed section selected from a plurality of feed sections, regardless of active agent sections not selected. In some embodiments, the implementation of the device is designed to simultaneously heat the section with the source material and the flow of air through this section with the source material to vaporize the active substance by heating.

In some embodiments, the source material is located in a plurality of sections. Optionally, the sections are insulated from one another with thermal or electrical insulation. Alternatively, the source material is located in one continuous section.

Optionally, only a portion of the continuous section is heated at any given time. Optionally, a plurality of sections are heated simultaneously to deliver a combination of actives.

In some embodiments, the source material is protected by a sealant. In some embodiments, the implementation of the sealant is a design and/or material that is impervious to air. In one example, the sealant is a foil, such as stainless steel foil. In some embodiments, the sealant includes a control area in which one or more through holes may be provided to allow air to pass through the sealant and through the parent material.

Optionally, holes are made during use.

In some embodiments, the control area of the sealant includes areas sensitive to mechanical stress, and at least one hole can be made in the sealant by applying force. In one example, a force in the form of air pressure is applied to the control region when the user inhales. In another example, a knife or punch is used to perforate the sealant. Additionally or alternatively, the control area of the sealant includes areas sensitive to temperature, and at least one hole can be made in the sealant by heating the sealant. Additionally or alternatively, an electric current is applied to the sealant to make at least one through hole.

Additionally or alternatively, the control area of the sealant includes areas that are sensitive to chemicals.

In some embodiments, the implementation of the sealant is designed to heat the source material to vaporize at least one active agent. For example, if the sealant is electrically resistive, it can heat the parent material when an electric current is applied to it. Optionally, the sealant includes a shape memory material that deforms when heated to allow air to pass through the sealant.

In some embodiments, heating of the sealant is performed using an additional component, such as magnetic induction of the sealant or other components; heat transfer to sealant or other components by radiation; heat convection from a heat source and/or other mechanisms suitable for heating the sealant. Optionally, the sealant includes a heat-sensitive material that dissolves when heated, allowing air to flow through.

In some embodiments, the heating element includes and/or is connected to electrodes that are energized to heat a temperature sensitive area, such as a sealant area. In some embodiments, the heating element includes a heated plate, a hot air source (eg, generator), a heat emitter, and/or any other suitable heat source.

In some embodiments, the holes provided in the sealant allow air flow in one direction while preventing reverse flow of the active agent. In some embodiments, the holes in the sealant can be resealed, for example, after the starting material has been used up.

Alternatively, the parent material is enclosed in and/or otherwise contacted with an element that is already air permeable, such as a mesh or perforated foil.

In some embodiments, the implementation of the device includes an air element designed to direct the flow of air through the section with the source material. Optionally, the air element dynamically moves (eg, by sliding, pulling, rolling) over the parent material. In some embodiments, the air element includes an array of electrodes for energizing the heating element and/or sealant of a selected feed section to heat the feed and/or perforate the sealant.

In some embodiments, the air stream is heated before passing through the parent material. Optionally, in embodiments where the parent material is encapsulated in and/or coated with a sealant that is impermeable to air, the heated airflow forms at least one through hole in the sealant to allow air to pass through at least a portion of the parent material.

In some embodiments, air drawn into the device in response to the suction force generated by the user's inhalation is directed through the source material section. In some embodiments, air passes through the parent material in thickness, such as entering through a first surface of the material and exiting through a second, optionally opposite, surface of the parent material. Additionally or alternatively, air enters and leaves the starting material on one side.

In some embodiments, heat is used to extract and/or otherwise release at least one active agent from the starting material and/or to open the sealant simultaneously with the passage of air through it. Air saturated with the active substance exiting the source material section is then delivered to the user via inhalation.

In some embodiments, the heating element and/or the air element and/or the electrical supply element (eg, electrodes) are aligned with each other and with one or more feed sections. Optionally, one or more of the heating element and/or the air element and/or the electrical supply element functions as a drive to open one or more openings (e.g. holes, perforations, slits) in the sealant after alignment with the sealant test site to let air pass through it. In some embodiments, the alignment is temporary. In some embodiments, the alignment of two or more of the heating element and/or the air element and/or the electrical supply element with respect to each other is controlled by software settings. Optionally, the controller of the inhalation device is for controlling the activation and/or positioning of the heating element and/or the air element and/or the element for supplying electricity in order to effect the alignment.

Optionally, alignment is performed before and/or during use of the selected section(s). Optionally, the alignment is maintained until the source material in the selected section is consumed and/or until another section is used with the source material.

In some embodiments, the amount of starting material in each section includes one dose of the active agent. In one embodiment, the device includes one section of the source material. Optionally, the amount of starting material in one section includes one dose of the active substance. In some embodiments, the amount of source material in one section is sufficient for a plurality of delivery events, which may include multiple breaths of the user. Optionally, the device is configured such that, at each delivery event, a smaller amount of active agent compared to the amount delivered at the previous delivery event is delivered to the user.

In some embodiments, the implementation of the device includes a loading mechanism (for example, in which the air element moves from the used section with the source material to the unused section). Optionally, the loading mechanism is controlled by the user, allowing the latter to trigger the transition of the device to an unused section of source material at will. A potential benefit of a user-controlled loading mechanism may include a psychological effect in which the user anticipates the maximum benefit from a new dose.

Additionally or alternatively, the loading mechanism may be operated automatically.

In some embodiments, the starting material comprises or consists of tobacco. In some embodiments, the starting material comprises or consists of cannabis.

Additionally or alternatively, the starting material includes or consists of other plant substances.

In some embodiments, the source material is the only material used in the device, or comprises at least 90% or at least 95% by weight of the material used in the device. Optionally, the saturated air flow delivered by the device to the user includes only one or more active substances extracted only from the source material. Optionally, any active agent in the saturated air stream delivered by the device to the user is restricted to odor and/or taste molecules.

Used in this document, the term "active substance" means a substance that evaporates under the action of heat, which includes a compound that has at least one medicinal and/or somatic and/or psychotropic effect. Optionally, the compound includes one or more cannabinoids, for example: tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN). Optionally, the compound comprises one or more alkaloids, for example: nicotine and/or 1,2,3,4-tetrahydroisoquinolines, anabasine, anatabine, cotinine, myosmin, nicotrine, norcotinine and/or nornicotine. In some embodiments, the heat vaporizable material vaporizes at a temperature requiring significant external heat input to achieve a temperature above ambient. For example, the substance evaporates at a temperature in the range of 80°C to 250°C, or in another range having the same, higher, lower and/or intermediate limits, for example 160 - 230°C. In some embodiments, the substance vaporizes at a temperature above 80°C, 100°C, 150°C, 200°C, 230°C, or other higher, lower, or intermediate temperature. In some embodiments, the time period until the evaporation temperature is reached is, for example, an interval of approximately 100 ms - 5 s, 100 - 750 ms, 150 - 300 ms, or another interval having the same, higher, lower and / or intermediate limits . Specifically, the time period is, for example, 250 ms, 500 ms, 1000 ms, or other higher, lower, or intermediate value.

In some embodiments, the sealant covers the entire parent material such that all of the material is protected by the sealant and there is no exposed material.

In some embodiments, the device has a substantially known cigarette shape, including, for example, a cylindrical shape. Alternatively, the device is in the form of a substantially flat strip and/or includes any other form suitable for delivering at least one active agent via inhalation.

One aspect of some embodiments relates to creating a channel for air flow between one or more selected sections with the source material and the exit to the user. In some embodiments, creating an airflow channel includes modifying the state of the airflow channel associated with one or more selected sections from a state in which airflow cannot pass to a state in which airflow can pass. In some embodiments, the implementation of the blocking element is missing, moved, removed and/or otherwise removed from the channel to allow air to pass. Once the channel is unblocked, air can flow to the parent material and optionally through the parent material of one or more selected sections. In some embodiments, the feedstock is heated in conjunction with (simultaneously and/or shortly before and/or after) the creation of an airflow path to extract at least one active from the feedstock and deliver that active through the airflow to the user. In some embodiments, heating is triggered by monitoring some airflow parameter (eg, pressure).

In some embodiments, the implementation of the sections with the source material remain stationary relative to each other. In some embodiments, the source material section remains stationary with respect to one or more of: a heating element associated with this section and designed to heat the source material, a channel associated with this section and passing between the section and exit to the user, the body of the source material cartridge .

Some embodiments include an actuator for creating a channel for air flow. For example, in some embodiments, the actuator is configured to move the blocking element (e.g., to open the feed section cover), align the channel opening with the air flow outlet, and/or otherwise modify the channel to allow air to flow to the feed. In some embodiments, the actuator is configured to turn on feed material heating, such as by closing an electrical circuit to turn on a heating element associated with a selected feed section. In some embodiments, after the duct is closed, heating is started or increased in response to the detection of airflow, such as in response to a user's inhalation.

In some embodiments, the actuator is operated in manual mode. Additionally or alternatively, the actuator operates in automatic mode, for example under the control of a device controller.

In some embodiments, operations such as selecting one or more feed sections and/or turning on feed material heating and/or modifying (eg, opening) the air flow path are mechanical. Additionally or alternatively, said operations are controlled or triggered by electronic means, such as a solid state switch such as a transistor.

One aspect of some embodiments relates to the use of a fluid that changes its viscosity as a starting material sealant. In some embodiments, a fluid that changes its viscosity in response to a change in temperature, such as silicone oil, coats at least a portion of the starting material. Optionally, the fluid is located on a grid or other scaffold containing the source material. In some embodiments, after the mesh is heated, the viscosity of the liquid decreases and the liquid drains (in one example, the liquid flows off the mesh and then collects in one or more side chambers), thereby exposing at least a portion of the feed material to airflow. Optionally, after the heating is stopped, the liquid cools and spontaneously returns to the place where the open area was previously covered. In some embodiments, changes in the surface tension and/or wetting properties of the fluid cause movement of the fluid, such as causing the fluid to drain to its original position. Optionally, the capillary action of the liquid allows it to pass through small diameter channels extending to and/or away from the grid.

One aspect of some embodiments relates to a device for receiving a plurality of cartridges, each of which includes one or more sections of source material, and the device, by choice, is designed to use sections according to their contents. In some embodiments, a plurality of source material sections are selected for use in a given order and/or on demand based on their content and/or location. In some embodiments, cartridge feed sections and/or different cartridges differ from each other in at least one of: source material type(s), active agent(s) type(s), amount(s) of source material(s). materials) and the amount(s) of the active substance(s).

The term "substrate" as used herein in connection with some embodiments may include a bar, a solid structure, a surface having a certain thickness, and/or other feature, including holes or grooves, which may contain the starting material.

The term "framework" as used herein in connection with some embodiments may include a structure having large void spaces, a shell, a cage-type casing, and/or any other element with spaces or sections that may contain source material.

Both the terms "substrate" and "framework" as used herein are intended to include a structure suitable for containing the starting material in one or more of the available spaces.

It should be noted that the at least one active agent delivered to the user is not limited to the form of a vapor and may additionally or alternatively be in the form of an aerosol.

Before at least one embodiment of the invention is explained in detail, it should be said that the invention is not necessarily limited in its application to the details of construction and arrangement of components and/or the methods set forth in the description and/or shown in the drawings and/or in the examples. The invention may have other embodiments or may be practiced in a variety of ways.

Now with reference to the drawings, where in FIG. 1A is a flow diagram of a method of operating a vaporizer for delivering at least one active agent to a user via inhalation, in accordance with some embodiments.

In some embodiments, the implementation of the device includes a cartridge or in some embodiments, the implementation is designed to install a cartridge that includes a number of separate sections (120) with the source material. In some embodiments, the implementation of the device includes one section with the source material.

In some embodiments, the parent material is coated with a sealant, such as in contact with one or more surfaces of the parent material. Optionally, the sealant is an artificial sealant, such as an electrically resistive material, which is optionally in the form of a foil, such as a metal foil.

In some embodiments, the implementation of the sealant does not allow air and/or moisture to enter the source material. Optionally, the sealant prevents the starting material and/or the active substance from evaporating and/or oxidizing and/or decomposing. In some embodiments, the sealant is made of a material suitable for heating the parent material, for example, by applying electrical current and/or a stream of warm air and/or radiation to the sealant, such as infrared heating and/or other heating methods.

In some embodiments, at least one feed section is not sealed (122).

Optionally, all of the respirable actives in the device, or at least 90% or at least 95% by weight of the respirables in the device, are encased in the sealant and their inhalation coincides with the depressurization. Optionally, at least a portion of the sealant becomes air permeable, allowing air to pass to and through the parent material. In some embodiments, the implementation of depressurization (for example, when making one or more through holes in the sealant) is performed by applying mechanical force to the sealant. The mechanical force may be applied in some embodiments by airflow and/or by adjusting the position of the airflow conduction system. Optionally, this is carried out by the device as a necessary step for inhaling any active substances through the device. Additionally or alternatively, the sealant includes one or more temperature-sensitive control areas, optionally including a temperature-sensitive material and/or structure, and depressurization is performed by heating the sealant. Optionally, the temperature sensitive control regions include a shape memory material such as nitinol.

In some embodiments, the source material is contained and/or otherwise in contact with an element that is already air permeable, such as a mesh or perforated foil.

In some embodiments, the device is designed to simultaneously direct the flow of air to and through the source material of one or more selected sections and to heat the source material in at least one of the selected sections so that the active substance is released when the source material (124) evaporates.

In some embodiments, the device is designed to deliver more than one active agent at the same time.

In some embodiments, the device includes an air element for directing flow through the feed section. Optionally, air entering the device, for example due to the suction force generated by the user's inhalation through the device, is conducted by the air element to the source material. In some embodiments, the implementation of the air element is designed to move through the source material, such as from section to section.

In some embodiments, the implementation of the device is designed to heat the source material. In some embodiments, the sealant (eg, foil) and/or heating element (eg, mesh) in contact with the source material is heated, eg, by applying electricity. In some embodiments, the air element includes electrodes for conducting current to the sealant and/or the heating element. Additionally or alternatively, the air element is designed to direct the flow and to heat the section with the source material, for example, includes a heating element (for example, a grid).

Additionally or alternatively, the heating of the source material is carried out by preheating the air flow, which is directed through the source material.

In some embodiments, the user's inhalation through the device triggers the movement of the air element towards the source material section that has not yet been consumed. In some embodiments, the user's inhalation through the device triggers the heating of the source material. In some embodiments, the user's inhalation through the device triggers a depressurization of the sealant on the parent material.

In some embodiments, the air that exits the heated source material includes vapors of at least one active agent released from the source material and is delivered to the user via inhalation (126).

In some embodiments, steps 122-126 are repeated on one or more different feed sections (128). Optionally, this process is repeated on the user's next breath. In some embodiments, the subsequent feed section is automatically depressurized. In some embodiments, the implementation of the air element is automatically moved to the next section with the source material. Additionally or alternatively, the air element is manually moved to the subsequent feed section. In some embodiments, the previously heated section sealant is resealed to prevent air from passing through the already heated starting material or to reduce the amount of air passing.

On FIG. 1B schematically shows a device for delivering at least one active agent by inhalation, according to some embodiments of the invention.

In some embodiments, the device is for therapeutic use. Additionally or alternatively, the device is intended for recreational use, such as the vaporization of tobacco and/or cannabis.

In some embodiments, the device 100 includes a housing 102; mouthpiece 104; a cartridge, such as 106 and/or 107, comprising one or more feedstocks; a power supply 108 for supplying electricity 109 to the cartridge to vaporize the active agent(s) by heating the raw material(s); and/or an air flow system 110 directing air flow through the heated source material section and through the mouthpiece for inhalation by the user. Optionally, the device includes a controller 112.

In some embodiments, a cartridge such as 107 includes a separate, discrete feed section 114. Alternatively, a cartridge such as 106 includes a single continuous feed located in one or more feed sections. In some embodiments, the source material is located in or otherwise in contact with the element 111, which is designed to heat the source material (for example, when it is energized) and / or to provide structural support with the source material, for example in the form of a frame containing the source material. In some embodiments, the implementation of the framework contains only the source material. Optionally, the source material is contained in separate sections, such as sections separated by walls. Optionally, the separation between the sections is designed to thermally and/or electrically insulate the sections with the source material from each other. Optionally, separation between sections prevents the sections from being in the same airflow path. Alternatively, the starting material is in the form of a continuous mass contained in a scaffold.

In some embodiments, element 111 is a mesh or foil. Optionally, the foil is air permeable. Alternatively, the foil is airtight and becomes airtight during use, for example as discussed herein below.

In some embodiments, the implementation of a discrete cartridge, such as 107, includes thermal or electrical insulating parts 116 located between the sections with the source material. In some embodiments, insulating members 116 include or consist of one or more of the following materials: liquid crystal polymer (LCP), Ultem, Teflon, Torlon, Amodel, Ryton, Forton, Xydear, Radel, Udel, polypropylene, Propylux, polysulfone, polyethersulfone, acrylic , ABS, nylon, PLA, polybenzimadazole, polycarbonate, polyetherimide, polyethylene, polyphenylene oxide, polyphenylene sulfide, polystyrene, polyvinyl chloride, other thermoplastic, polyimide (PI), polyaryletherketone (PAEK) such as polyetheretherketone (PEEK), polyetherketone (PEK), or polyetherketoneetherketoneketone ( PEKEKK), or a fluoropolymer such as polytetrafluoroethylene (PTFE), polyvinylidene fluoride (PVDF), ethylenetetrafluoroethylene (ETFE), PVDFELS, or fluorinated ethylene propylene (FEP) and/or other polymeric material. In some embodiments, parts 116 include a conductive material (eg, aluminum). Optionally, parts 116 include an electrically insulating layer in the form of an anodized coating.

A potential advantage of the LCP and/or PEEK material is good resistance at temperatures higher than the temperature required to vaporize the starting material contained in the cartridge, for example a vaporization temperature of 230°C.

In some embodiments, heat is applied only to a selected feed section (in cartridge 106 or 107), for example, by applying electricity. In some embodiments, the implementation of the air is directed only or for the most part through the selected section with the source material.

In some embodiments, each feed section is heated independently of the other sections, such as by energizing a separate electrically resistive heating element in contact with that section's feed. In some embodiments, the implementation of the heating is performed when the air is directed through the section with the source material for delivery to the user through the system 110 of the air.

In some embodiments, the heated section (or sections) is controlled by adjusting the airflow through the device and/or adjusting the heat. In some embodiments, the airflow is controlled as it passes through a specific feed section or portion thereof. Additionally or alternatively, heating is controlled to vaporize a specific feed section or a portion of it, for example by heating only a portion of element 111. In some embodiments, no feed sections other than a specific section are heated. Optionally, non-heated sections include sections that are already heated and/or sections that are not yet heated but are not a specific section.

In some embodiments, the implementation of the system 110 conduct the air flow is designed to pass the flow of air in a limited volume of the device. In some embodiments, the air flow is directed, optionally through one or more channels, to pass through a specific feed section. Additionally or alternatively, a degree of traction, obstruction and/or resistance to flow is created in the way the user inhales through the device to restrict flow.

In some embodiments, the device includes a controller 112. In some embodiments, the amount of active agent delivered by the device is controlled by the controller 112, for example, by adjusting one or more of: heating parameters (e.g., temperature, duration), flow parameters, amount of feedstock being heated and/or other options.

In some embodiments, the starting material includes plant material such as tobacco and/or cannabis and/or other plant materials. In some embodiments, the released active agent includes a compound having at least one of a medicinal and/or somatic and/or psychotropic effect. Optionally, the compound comprises THC and/or other cannabinoids and/or terpenes and/or nicotine and/or other alkaloids and/or 1,2,3,4-tetrahydroisoquinolines, anabazine, anatabine, cotinine, myosmin, nicotrine , norcotinine and/or nornicotine. In some embodiments, the starting material is a volatile material distributed over a pallet containing the carrier material. Optionally, the carrier material includes at least one plant matter, such as cannabis, tobacco, and/or other plant matter. Additionally or alternatively, the carrier material includes a porous and air-permeable absorbent matrix, such as foam, sponge, felt, and/or other fibrous matrix, which absorbs the active agent to hold it in place. In some embodiments, the absorbent matrix is not substantially brittle and has sufficient strength to, for example, allow other cartridge features, such as a heating element, to be directly attached to or in the absorbent matrix without the need for additional mechanical support to maintain surface and/or structure integrity. absorbent matrix. In some embodiments, the pallet is brittle, for example, includes granules, fibers, or other fine structure compacted to form a pallet.

In some embodiments, the source material includes one or more isolated materials, essential oils, extractables, and/or synthetic compounds.

In some embodiments, the starting material comprises plant material, including at least one plant material selected from the group consisting of the following plants: Cannabis sativa, Cannabis indica, Cannabis ruderalis, Acacia spp., Conocybe cyanopus, Conocybe smithii, Copelandia bispora, Copelandia cambodgeniensis, Copelandia cyanescens, Copelandia tropicalis, Galerina steglichii, Gymnopilus aeruginosus, Gymnopilus luteofolius, Gymnopilus spectabilis, Gymnopilus purpuratus, Inocybe aeruginascens, Inocybe calamistrata, Inocybe corydalina var. erinaceomorpha, Inocybe haemacta, Panaeolus africanus, Panaeolus castaneifolius, Panaeolus subbalteatus, Pluteus salicinus, Psilocybe allenii, Psilocybe antioquensis, Psilocybe arcana, Psilocybe atlantis, Psilocybe aucklandii, Psilocybe australiana, Psilocybe aztecorum, Psilocybe azurescens, Psilocybe baeocystis, Psilocybe bohemica, Psilocybe brasiliensis, Psilocybe caerulescens Psilocybe caerulipes Psilocybe columbiana Psilocybe cordispora Psilocybe cubensis Psilocybe cyanescens Psilocybe cyanofibrillosa Psilocybe fagicola Psilocybe fimetaria Psilocybe heimii Psilocybe hispanica americana, Psilocybe mexicana, Psilocybe moravica, Psilocybe natalensis, Psilocybe ovoideocystidiata, Psilocybe pelliculosa, Psilocybe portoricensis, Psilocybe quebecensis, Psilocybe samuiensis, Psilocybe sanctorum, Psilocybe semilanceata, Psilocybe semperviva, Psilocybe sierrae, Psilocybe silvatica, Psilocybe stuntzii, Psilocybe stuntzii var. tenuis, Psilocybe subaeruginosa, Psilocybe subcubensis, Psilocybe tampanensis, Psilocybe uxpanapensis, Psilocybe villarrealiae, Psilocybe weilii, Psilocybe xalapenensis, Psilocybe yungensis, Psilocybe zapotecorum, Amanita muscaria, ayahuasca, Atropa belladonna, Areca catechu, Brugmansia spp., Brunfelsia latifolia, Desmanthus illinoensis, Banisteriopsis caapi, Trichocereus spp., Theobroma cacao, Capsicum spp., Cestrum spp., Erythroxylum coca, Solenostemon scutellarioides, Arundo donax, Coffea arabica, Datura spp., Desfontainia spp. Argyreia nervosa, Hyoscyamus niger, Tabernanthe iboga, Lagochilus inebriens, Justicia pectoralis, Sceletium tortuosum, Piper methysticum, Catha edulis, Mitragyna speciosa, Leonotis leonurus, Nymphaea spp., Nelumbo spp. Ipomoea violacea, Panaeolus spp., Myristica fragrans, Turbina corymbosa, Passiflora incarnata, Lophophora williamsii, Phalaris spp., Duboisia hopwoodii, Papaver somniferum, Psychotria viridis, spp., Salvia divinorum, Combretum quadrangulare, Trichocereus pachanoi, Heimia salicifolia, Stipa robusta, Solandra spp., Hypericum perforatum, Peganum harmala, Tabernaemontana spp., Camellia sinensis, Nicotiana tabacum, Nicotiana rustica, Virola theidora, Voacanga africana, Lactuca virosa, Artemisia absinthium, Ilex paraguariensis, Anadenanthera spp., Corynanthe yohimbe, Calea zacatechichi, Coffea spp. (Rubiaceae), Sapindaceae spp., Camellia spp., Malvaceae spp., Aquifoliaceae spp., Hoodia spp. Chamomilla recutita, Passiflora incarnate, Camellia sinensis, Mentha piperita, Mentha spicata, Rubus idaeus, Eucalyptus globulus, Lavandula officinalis, Thymus vulgaris, Melissa officinalis, tobacco, aloe vera, angelica, anise, ayahuasca (Banisteriopsis caapi), barberry, black hornwort, blue lotus, burdock, chamomile, cumin, pitecolobium cat's claw, clover, comfrey, corn stigmas, couch grass, damiana, dandelion, ephedra, eucalyptus, evening primrose, fennel, pyrethrum maidenhair, snow tree, garlic, ginger, ginkgo, ginseng, goldenrod , goldenseal, asiatica centella, green tea, guarana, hawthorn, hops, horsetail, hyssop, kola nut, kratom, lavender, lemon balm, licorice, lion's tail (wild dagga), peruvian maca, marshmallow, meadowsweet, spotted milk thistle, motherwort, passionflower, passion flower, peppermint, argemone, purslane, raspberry leaf, poppy seed, sage, saw palmetto, sida cordifolia, hamia, spearmint, calamus, common harmala ram (Peganum harmala), thyme, turmeric, valerian, wild yam, mugwort, yarrow, mate and yohimbe. In some embodiments, the starting material includes one or more active substances extracted and/or isolated from one or more of the above plants, and/or a synthetic version of such active substances.

In some embodiments, the starting material includes different plants, different varieties, different mixtures, different additives, and/or different concentrations of one or more substances.

In some embodiments, the feed material vaporizes at a temperature requiring a significant external heat input to achieve a temperature above ambient. For example, a substance vaporizes at a temperature in the range of 80°C - 250°C, or in another range having the same, higher, lower, and/or intermediate limits, for example, 160 - 230°C. In some embodiments, the substance vaporizes at a temperature above 80°C, 100°C, 150°C, 200°C, 230°C, or other higher, lower, or intermediate temperature. In some embodiments, the period of time required to reach the evaporation temperature is, for example, approximately 100 ms - 5 s, 100 - 750 ms, 150 - 300 ms, or another interval having the same, higher, lower, and/or intermediate borders. Specifically, the time period is, for example, 250 ms, 500 ms, 1000 ms, or other higher, lower, or intermediate value. In one example, nicotine is extracted at a boiling point of approximately 247° C. for a period of time of approximately 3 seconds or less. In some embodiments, element 111 is electrically resistive. Optionally, the element 111 consists of or includes a metal, such as nichrome, FeCrAl, cupronickel, titanium, and/or stainless steel.

In some embodiments, element 111 is packaged in thermal contact with a source material to heat the source material. Thermal contact includes, for example, direct contact or contact over a thermally conductive layer providing a high rate of heat transfer (for example, comprising a high thermal conductivity material such as copper, aluminum, bronze, or steel, and/or having a thin-walled structure less than about 10 µm thick, 20 µm, 25 µm, 50 µm or other greater, lesser or intermediate thickness). In some embodiments, thermal contact includes a sufficiently tight connection between the tray and element 111, when the tray pulls together substantially the full angle of thermal radiation of a part of the element lying on it, for example, greater than 90%, 95%, 99%, or another greater, lesser, or intermediate value. In some embodiments, the maximum current applied to the electrode is approximately 1-10 A, such as approximately 1 A, 2 A, 4 A, 6 A, or other higher, lower, or intermediate current.

In some embodiments, the thermal contact includes an element 111 extending over the pallet in contact with one or more of its surfaces, such as one side or two opposite sides of the pallet having the largest area. In some embodiments, the implementation of the thermal contact includes an element 111, at least partially inserted into the tray.

In some embodiments, element 111 is air permeable. In some embodiments, the tray is air permeable. Permeability is determined by certain conditions, such as passing air at ambient temperature through a heated tray assembly and element 111 at suction pressure, such as suction pressure generated by inhalation and/or pressurization generated on the side opposite the air inlet side of the cartridge. In some embodiments, the applied pressure is 5-20 mmHg, 10-25 mmHg, 5-30 mmHg, 25-40 mmHg, 30-50 mmHg . or another interval having the same, higher, lower and/or intermediate boundaries. In some embodiments, the sump has a breathable structure that provides a flow rate of at least 0.5 liters of gas per minute, or even at least 0.75 liters of gas per minute or 1 liter of gas per minute under a vacuum of at least 1 to 5 kPa (-1 - (-5) kPa). In some embodiments, the pallet has this permeability in its packaged form. In some embodiments, this permeability is achieved during the heating of the sump, for example, due to evaporation, drying, melting and/or burning of the components of the sump.

In some embodiments, power supply 108 is configured to supply sufficient electrical energy to heat a selected number of feed sections 114. Optionally, power supply 108 is configured to supply sufficient electrical energy to heat all of the feed material in the device. In some embodiments, the power source is a battery. Optionally, the battery is rechargeable. Optionally, the battery is charged from a source outside the device.

On FIG. 2A-C show three forms of connection between a starting material and an electroresistive heating element according to some embodiments of the invention.

In some embodiments, the source material 200 is connected to an electrically resistive heating element 202, such as a mesh or foil.

In some embodiments, the connection between the source material and the heating element is designed to provide uniform heating of the source material.

Optionally, the starting material is shaped before or during installation to conform to the optional flat shape of the heating element. Placing the feed material in a flat form is a potential advantage as the increased surface area and/or more uniform thickness potentially allows for faster and/or more evenly distributed heating and/or airflow during evaporative dosing and delivery. In some embodiments, the thickness of the starting material, measured in the direction in which the airflow passes through the starting material, is 0.5-5 mm, or 0.5-2 mm, or 0.5-1.5 mm, such as 1 mm , 2.5 mm, 4 mm or in between, greater or lesser thickness.

In the example shown in FIG. 2A, the feed material is located between two heating elements. A potential benefit of the double-sided feed closure used in some embodiments is the increased rate and/or uniformity of evaporation when current is applied to the heating element.

In the example shown in FIG. 2B, the bottom surface of the raw material is in contact with the heating element. Alternatively, the top surface of the starting material may be in contact with the heating element.

In the example shown in FIG. 2C, the heating element is inserted into the starting material.

In some embodiments, the source material 200 and/or the heating element 202 are positioned to allow airflow 204 to pass through. Optionally, the heating element 202 is a mesh and/or other breathable structure. Optionally, the parent material 200 is comprised of or contained within a porous matrix and/or otherwise positioned to allow air flow through it.

Alternatively, the heating element is airtight. Optionally, the heating element is designed to become permeable during use.

In some embodiments, the implementation of the heating element includes an infrared heater.

On FIG. 3 shows a design in which heating element 300 can move relative to source material 302, in accordance with some embodiments of the invention.

In some embodiments, optionally during use, the heating element 300 is moved to a position where it is in contact with the source material or part thereof. Optionally, the heating element is configured to move over the feed to heat another portion of the feed. Optionally, the heating element is sized to be in contact with a portion of the starting material containing an amount of active substance which, after evaporation, will provide one predetermined dose. In some embodiments, the starting material includes a support structure (not shown). Optionally, the support structure is air permeable. Optionally, the support structure is heat-resistant. In some embodiments, the movable heating element is designed to be attached to a support structure. In some embodiments, the movable heating element is formed as part of an air element and/or includes an air element, such as the one described herein below, that directs airflow 304 through the heated active agent section.

On FIG. 4A-C show methods and/or structures for dynamically changing the air permeability of a heating element and/or feedstock sealant, in accordance with some embodiments of the invention. In some embodiments, the implementation of the sealant is designed to heat the source material and, therefore, works as a heating element.

In some embodiments, the heating element, or at least a portion of the heating element, is already air permeable. Alternatively, the heating element is sealed and during use it will depressurize to allow air to pass through the starting material. On FIG. 4A-C show various methods and designs for dynamically changing the air permeability of the heating element and/or the sealant of the starting material.

In some embodiments, such as the one shown in FIG. 4A, the heating element is a foil 400 that includes one or more force-sensitive control areas 402. When a force (such as pressure, stretching, crushing, and/or bending force) is applied to the foil, its force-sensitive areas or portions deform to allow air to flow through it. Optionally, the flow is the air flow generated by the user breathing through the device.

Optionally, force sensitive control areas are etched into the foil.

Additionally or alternatively, the foil is perforated. Additionally or alternatively, the foil is folded to form a scale-like arrangement.

In some embodiments, the implementation of the heating element includes control areas that are sensitive to temperature. Optionally, the temperature sensitive areas include a shape memory material. Optionally, during heating, the sections or parts are deformed to allow airflow to pass through them. In some embodiments, as the heating element cools, the temperature sensitive areas close. A potential advantage of using temperature sensitive areas may include the inherent structure of the air ducts allowing airflow to flow only through heated parts while providing a barrier to flow through unheated parts. Optionally, the direction of deformation results in increased surface contact between the heating element and the material.

In the example in FIG. 4A, foil 400 includes 316L stainless steel foil, or alternatively, a conductive shape memory material such as nitinol and/or Cu-Al-Ni alloys and/or Fe-Mn-Si-Cr-Ni alloys, and/ or Cu50Zr50 alloys. In some embodiments, a scaly pattern is etched into the foil. Optionally, when force is applied and/or when heated, the foil deforms (e.g., expands or collapses) and at least some of the regions change shape to allow air to pass through, such as holes 404. In some embodiments, the application forces in the opposite direction and/or cooling of the foil deforms the areas that recover their original shape, and the holes through which the air passes are closed.

In some embodiments, such as the one shown in FIG. 4B, sealant 414 is designed to function as a flow valve. Optionally, when suction force and/or air pressure is applied (for example, during a user's inhalation through the device), one or more valves 406 in sealant 414 are moved to allow air to pass through the source material 408. Optionally, the valves are configured as sections sealant. In some embodiments, when the suction stops (eg, when inhalation is stopped), the valves move to the closed position. In the configuration described, it may be preferable to use a sealant in the form of a foil, such as stainless steel foil, or a flexible sealant made, for example, of silicone.

In some embodiments, the heating element 416 is located between the sealant 414 and the starting material 408.

In some embodiments, as shown, for example, in FIG. 4B, an air element 410 is used. Optionally, the air element is moved (eg, slid) over the sealant 414 and/or over the heating element 416 and/or directly over the feed and/or through the support structure. In some embodiments, the air element is positioned above the sealant portion such that only the valves provided in that portion are opened to allow air to pass, for example, when suction and/or air pressure is generated by the air element.

In some embodiments, such as the one shown in FIG. 4C, heating element 418 includes a shape memory material such as nitinol. Optionally, during heating, one or more petals 412 in the foil deform (eg, move away from the parent material) to allow air flow. In some embodiments, upon a power outage and as the heating element cools, the petals deform back into their closed shape. Additionally or alternatively, mechanical force can be applied to reseal the petals, for example using a stamp or roller.

Additionally or alternatively, the heating element is air permeable and is covered with a seal that will release during use to expose the heating element.

Additionally or alternatively, a mechanical element can be used to perforate the heating element, for example in the form of a rotary knife or punch.

Optionally, in embodiments where the heating element is air permeable and includes a sealant or cover, such as as discussed above, a mechanical element is used shaped and/or sized to open and/or perforate and/or remove part of the sealant.

Additionally or alternatively, the sealant or heating element cover may be manually removed by the user and/or removed mechanically, such as when the cartridge is installed in the device.

In some embodiments, the implementation of the sealant of the source material includes a silicone membrane. Optionally, the starting material is enclosed in a mesh or foil, and the silicone membrane is the covering of the mesh or foil. Optionally, the silicone membrane has a thickness of 100 - 500 µm, eg 200 µm, 300 µm, 400 µm. In some embodiments, the silicone membrane includes open slits to allow air to pass through in response to pressure, such as air pressure applied when air is directed against the feed section, such as air pressure generated by inhalation. Additionally or alternatively, the sealant includes a thin layer of perfluoroalkoxide (PFA) film, for example having a thickness of 10-50 µm, such as 15 µm, 25 µm, 40 µm. Optionally, the film includes slits, such as those mentioned herein above. Optionally, this material is resilient enough that when there is no air pressure, the slits close into a hermetic state.

In some embodiments, the sealant coats a material that is intended to expand its volume when heat is applied to it, such as an inert, non-toxic, low boiling gas (eg, helium), a solid, and/or a liquid to be sublimated. Optionally, the application of heat causes the material to expand and break the sealant.

On FIG. 5A-B show two flow patterns in which an airflow is directed through a parent material to deliver active agent-laden air to a user, in accordance with some embodiments of the invention.

In some embodiments, the device 514 includes an air element 500 including one or more channels and/or valves suitable for directing air flow through the feed or a selected portion thereof. In some embodiments, the air element 500 includes a passage 502 through which suction occurs, such as during inhalation, directing the flow of air entering the device through at least a portion 504 of the source material 506.

In some embodiments, the air element 500 includes one or more electrical contacts (not shown) for supplying current to at least a portion of the heating element 508 that is in contact with the source material. In some embodiments, the electrical contacts are shaped to supply current to a limited area of the heating element corresponding at least in part to portion 504. Optionally, the electrical contacts are located at the edges of the air element, i. run on opposite sides of the original material.

In some embodiments, the air element 500 is capable of moving through the parent material, such as by sliding, rolling, pulling, and/or otherwise moving through the parent material. In some embodiments, air element 500 is moved manually, such as using a manual slider. Optionally, this slider can be moved by the user with one hand holding the inhalation device, such as with the thumb. Additionally or alternatively, the movement of the air element 500 is automatic. In embodiments in which the device includes a controller, the controller may be used to start, change and/or stop the movement of the air element.

In some embodiments, the air element moves between successive delivery events (ie, events in which active agent vapor is delivered to the user via inhalation), heating a separate portion of the source material in each event.

Optionally, the delivery event includes one breath. Alternatively, the delivery event includes some set of breaths. In some embodiments, the implementation of the air element is moved to another part of the source material only after a certain number of delivery events. Optionally, the number of delivery events can be specified.

Additionally or alternatively, the air element is capable of moving a portion of the feed after a predetermined portion or all of the feed in the currently heated section has been consumed.

In some embodiments, the air element is shaped to direct flow through more than one feed section. Optionally, a plurality of feed sections are heated when the air element is moved to a position suitable for supplying airflow and electrical power to that number of feed sections. Optionally, a plurality of sections are heated simultaneously. Alternatively, a plurality of active agent sections are heated one after the other. Optionally, the heating element is located in the same location for a plurality of breaths, with each breath associated with heating a separate portion or section of the feed material that is located in portion 504.

In the cross sectional view in Fig. 5A, the flow of air entering the passage 502 of the air element 500 is directed through a portion of the raw material 504 and continues to flow as air saturated with the active substance to the mouthpiece 510 for delivery to the user.

In the cross sectional view in Fig. 5B, the flow entering the device through opening 512 is forced through the feed 506. In this example, the air element 500 is positioned above the feed. Optionally, air saturated with the active agent is delivered to the user through a channel 508 extending to the mouthpiece 510.

On FIG. 6A-C show the mechanisms of movement of the air element on the source material, according to some variants of implementation.

On FIG. 6A is a schematic representation of the movement of the air element through the parent material 600, including, for example, movement by rolling, sliding, dragging through the parent material, and/or other means. Optionally, the air element is positioned above the parent material. Additionally or alternatively, the air element is located under the source material.

On FIG. 6B, the air element 602 includes a roller 604 for rolling on the surface of a parent material 600, according to some embodiments.

Optionally, roll 604 is coupled to a lever 606 for pulling and/or pushing the roll over feed 600. In some embodiments, roll 604 includes a mesh and/or foil and/or other perforated surface designed to be heated when current is applied to heat the starting material in contact with the roller.

Optionally, the roller is partially surrounded by a sealing area which directs the air flow in the desired direction.

In some embodiments, the implementation of the surface of the roller has spikes. Optionally, the studded surface is not perforated, but designed to make holes in the sealant covering the parent material, according to some embodiments.

On FIG. 6C, the cartridge 620 includes a source material 600 located in and/or between layers of air-permeable heating element 618, in accordance with some embodiments. Optionally, the air element 610 includes two opposite surfaces 612, located so that the source material 600 is between them. Channels 614 extend from these surfaces to mouthpiece 616, allowing air to pass through.

It should be noted that the examples of starting material described herein are in the form of flat strips, but other forms are possible, such as a tubular arrangement (eg, having a circular or polygonal cross-sectional profile) and/or any other shape.

On FIG. 7 is a schematic diagram of a dynamic air element for directing air through a selected feed section, in accordance with some embodiments of the invention. In this example, the source material is stacked in layers 702, with each layer located in the frame 700 and is a section with the source material. In this example, each layer includes a flat (optionally square) mass of starting material. It should be said that other forms of layers and/or forms of placement of the starting material are also possible.

In some embodiments, an electrical resistive element 712, such as a foil or mesh, that is designed to heat the source material is in contact with the source material, such as covering at least one surface of the source material and/or enclosing the source material on both sides of a hole in the frame .

In some embodiments, air element 706 includes a movable blocking element 704 designed to direct air only through a specific feed section. In the example herein, airflow 708 passes through air element passage 706, guided into middle section 710 by blocking element 704, passes through parent material 700, and then back into air element passage 706 for delivery to the user.

On FIG. 8A-B show the operation of an apparatus including a plurality of air elements, in accordance with some embodiments of the invention.

In some embodiments, a plurality of air elements are positioned to direct flow and/or supply electrical current to a plurality of respective feed sections that are associated with the air elements. In some embodiments, air flow is selectively directed through one or more air elements, and not directed through others. On FIG. 8A, the airflow is directed through the first air element 800, through the first piece of raw material 802, and on to the mouthpiece 808 for delivery to the user. On FIG. 8B, the airflow is directed through the second air element 804, through the second piece of stock 806, and on to the mouthpiece 808 for delivery to the user. Optionally, the first air element 800 is blocked to stop the flow through the first section 802 with the active substance after it has been used up. In some embodiments, the portion of the starting material through which air can pass, such as portion 802, includes a single dose of the active agent. Alternatively, portion 802 includes a plurality of dose sections, and each of them can be heated separately, for example, for each delivery event. Optionally, the portion is delivered to the user in a single delivery event (eg, on a single device action, optionally including one or more consecutive user breaths through the device).

On FIG. 9 schematically shows a heating element 900 for allowing air flow through a feed section 902 currently being heated and blocking flow through sections not currently in use, according to some embodiments. In some embodiments, the heating element 900, such as in the form of a foil containing the feedstock, includes one or more portions 904 that must become air-permeable during use to allow airflow to pass through the heated feedstock section. Optionally, this permeable portion of the foil is resealed after the heating is stopped.

Optionally, for example, at the next delivery event and/or after inhalation, another part of the foil becomes air-permeable, allowing the flow to pass through another part of the starting material.

In some embodiments, a portion of the foil, such as portion 904, is connected to an array of electrodes through which current is applied to the foil. Optionally, a plurality of foil pieces are connected to a plurality of respective electrode groups. Optionally, groups of electrodes are connected individually to different target sections with source material. In some embodiments, such as the device shown in this figure, the device includes a controller that is designed to control the heating of different sections of the source material separately.

On FIG. 10A-F show a cigarette-like device having a cylindrical shape, according to some embodiments of the invention.

On FIG. 10A is an isometric view of the device 1000, FIG. 10B shows a cross-sectional view of the device 1000, FIG. 10C and 10D show various partially enlarged views of device 1000.

In some embodiments, as shown in FIG. 10B, parent material 1002 has an annular cross-sectional profile. In some embodiments, the feedstock is sandwiched between the inner and outer layers of foil 1004 for heating the feedstock, such as by applying electrical power to the foil. In some embodiments, electrical power is supplied through a pair of electrodes 1006 designed to contact foil 1004. In some embodiments, the outer layer of foil is surrounded by housing 1010.

Optionally, the housing 1010 includes a durable inert material. In some embodiments, this durable inert material includes one or more of the following: liquid crystal polymer (LCP), polyetheretherketone (PEEK), Ultem, Teflon, Torlon, Amodel, Ryton, Forton, Xydear, Radel, Udel, polypropylene, Propylux, polysulfone, polyethersulfone, acrylic, ABS, nylon, PLA, polybenzimidazole, polycarbonate, polyetherimide, polyethylene, polyphenylene oxide, polyphenylene sulfide, polystyrene, polyvinyl chloride, other thermoplastic and/or other polymer material.

In some embodiments, between the outer foil 1004 and the housing 1010 is a cylindrical cavity 1008 through which air can pass. In some embodiments, a cannula 1012 is located between the proximal end 1014 and the distal end 1016 (see Fig. 10A). Optionally, the cannula serves as a conduit for active agent-laden air to flow towards the proximal end for delivery to the user.

In some embodiments, the distal end 1016 includes a sealed portion 1018 and an open portion 1020 (shown more clearly in FIG. 10D) located radially outward from the sealant and allowing air flow 1021 to enter the device around the sealant and pass into the cavity 1008 and circumferentially around outer foil 1004.

In some embodiments, air passes from the cavity 1008 in a radially inward direction through the outer foil, through the currently heated section of the source material, through the inner foil and into the cannula 1012, through which it passes into the mouthpiece 1022 located at the proximal end 1014 of the device. The air stream entering the mouthpiece 1022 includes at least one active substance, for example in the form of vapors obtained from a heated section of the source material. In some embodiments, the mouthpiece 1022 is capable of preventing circumferential flow (eg, flow in cavity 1008) into the user's mouth. Optionally, only axial flow can pass. In some embodiments, backflow of air (i.e., air flowing from the user to the source material or in the same direction) is blocked, for example, through the use of one or more check valves and/or other elements suitable for blocking backflow air.

In some embodiments, the implementation of the electrodes 1006 are able to move along the cylinder to heat another section of the source material. Additionally or alternatively, a plurality of electrodes are located along the length of the cylinder and are connected in turn to apply current to heat the corresponding portion of the foil.

On FIG. 10E and 10F show an electronic cigarette including a first part 1030 and a second part 1032. Optionally, the first and second parts are axially connected to each other to create an elongated cylindrical shape, as shown, for example, in FIG. 10F.

In some embodiments, the first part 1030 houses the battery 1034 and/or the controller 1036. Optionally, an indicator light 1038 (eg, an LED) is provided on the outside of the first part to indicate the battery charge level and/or for other operating indications.

In some embodiments, the second portion 1032 includes a feed cartridge 1040. In some embodiments, the implementation of the second part 1032 includes a mouthpiece 1042 located at the proximal end of this part. In some embodiments, the second part 1032 includes the device 1000 shown, for example, in FIG. 10A-10D.

In some embodiments, portions 1030 and 1032 are mechanically and/or electrically connected to each other, for example, through connectors 1044 that extend proximate first portion 1030 and are installed in portion 1032. Optionally, connectors 1044 are or include electrical connectors for supplying electricity to the cartridge 1040 to heat the feedstock in the cartridge.

Additionally or alternatively, other connectors may be used to connect the parts.

In some embodiments, airflow 1046 enters portion 1032 through an annular opening at the distal end of portion 1032, shown, for example, in FIG. 10F and in FIG. 10A. In some embodiments, the source material in the cartridge is protected by a sealant that is designed to be released during use, such as as described herein above to allow air flow 1046. In some embodiments, part 1032 is disposable and part 1030 is for at least some many use cases. Optionally, the 1034 battery is rechargeable.

In some embodiments, portion 1032 includes a chip (not shown herein) encoded with a delivery schedule and/or dose course and/or personal data of the user. Optionally, the connection between the parts is for data transfer (for example, via a USB connection), so that the controller 1036 controls the delivery according to the data encoded in the part 1032.

On FIG. 11A-C show various disposable and/or replaceable components of a device according to some embodiments of the invention.

In some embodiments, the entire device is intended for single use.

Alternatively, one or more components, such as the cartridge 1100 containing the starting material (shown in Fig. 11A), and/or the battery 1102 (shown in Fig. 11A), and/or the air element 1104 (shown in Fig. 11B), and/or flow channel 1106 (shown in FIGS. 11B and 11C) and/or mouthpiece 1108 (shown in FIGS. 11B and 11C) are disposable. The mouthpiece may be configured to allow air flow from the device to the user and/or may be a mouthpiece sleeve included with the device.

In one example shown in FIG. 11C, cartridge 1100, channel 1106, and mouthpiece 1108 are combined into one refill.

In some embodiments, one or more of the aforementioned components may be removed and optionally replaced between delivery events. Additionally or alternatively, one or more of the above components can be removed and optionally replaced for different users. Additionally or alternatively, one or more of the above components may be removed and optionally replaced after a certain period of time. Additionally or alternatively, one or more of the above components may be removed and optionally replaced after all of the starting material has been consumed.

A potential advantage of using disposable components as some or all of the components through which the air saturated with the active agent passes may include the avoidance of excessive accumulation of residue of condensed active agent after using, for example, a plurality of cartridges, which, in turn, may reduce the risk of unpleasant odor during use.

On FIG. 12A-E show different views of a substantially flat rectangular evaporator device according to some embodiments of the invention.

It should be noted that a flat rectangular device is the only shape provided as an example, and the device may have other shapes, optionally non-planar, such as tubular, disc-shaped, triangular, and/or others.

On FIG. 12A is an isometric view of the device 1200. FIG. 12B, the device outer casing 1202 (shown in FIG. 12A) is omitted to expose the underlying structure. On FIG. 12C does not show the top layer 1206 of the device to open the cartridge 1204. In FIG. 12D shows a bottom view of the device. On FIG. 12E shows an example of a device boot mechanism according to some embodiments.

In some embodiments, the top layer 1206 shown in FIG. 12B includes a longitudinal slot 1208 optionally extending between the proximal end 1210 and distal end 1212 of the device. In some embodiments, layer 1206 is made from a flexible material such as silicone and/or rubber.

In some embodiments, an element is used to direct the flow of air and/or to supply electricity to the cartridge. In some embodiments, such as those presented herein, this element is in the form of a movable carriage 1214, which may be at least partially installed in the slot 1208. Optionally, the movable carriage includes a nozzle 1216 (shown in Fig. 12C) extending through the slot to the cartridge 1204, to direct the air flow to the corresponding part of the cartridge. In some embodiments, nozzle 1216 is slidably seated in layer 1206 such that the material of layer 1206 seals the area around the nozzle, allowing most of the volume (e.g., 80%, 90%, 95% of the flow) or all of the flow to pass through the nozzle.

In some embodiments, such as in FIG. 12C, carriage 1214 includes electrodes 1224 and 1226 for energizing the cartridge.

Optionally, the electrodes are located on the side edges of the carriage 1214.

In some embodiments, the carriage 1214 is moved manually, such as by sliding on the outer casing of the device, as shown, for example, in FIG. 12E. Additionally or alternatively, the carriage 1214 may automatically move along the cartridge.

In some embodiments, such as those provided herein, the cartridge 1204 includes a source material 1218 (such as tobacco and/or cannabis) in contact with a coating that can act as a heating element and/or as a sealant of the source material. In this example, the source material is enclosed in a perforated foil 1220. In some embodiments such as those presented herein, the cartridge 1204 is in the form of an elongated strip.

Alternatively, the cartridge 1204 may have other shapes, such as cylindrical.

In some embodiments, the cartridge 1204 includes an insulating element, such as in the form of a longitudinally extending shelf 1222 shown in FIG. 12C.

Optionally, an insulating member is provided to separate electrodes 1224 and 1226 so that current can be applied to the section of the cartridge that is currently in contact with the carriage.

In some embodiments, cartridge 1204 includes a ratchet 1228 to move the carriage in one direction, such as from the distal end to the proximal end.

In some embodiments, in use, air 1232 enters the device (eg, suction caused by the user's inhalation) through the distal end 1212, as shown in FIG. 12D. The airflow is directed through nozzle 1216 to and through the feedstock in the carriage-heated section of the cartridge. Air saturated with the active agent 1234, after exiting the cartridge, flows along the underside of the cartridge to enter the mouthpiece sheath 1230 for delivery to the user.

In some embodiments, another wall (not shown here) is located against the bottom wall of the cartridge. Optionally, it is the inner surface of the housing and is a coating or seal, including, for example, non-perforated foil, preventing the release of air saturated with the active substance.

In some embodiments, the mouthpiece shell 1230 includes foil. In some embodiments, the mouthpiece shell is heat resistant and/or electrically insulating.

In some embodiments, the mouthpiece 1230 (in this example, in the form of a shell), and/or the cartridge 1204, and/or the battery, and/or the flow channel (for example, between the bottom of the cartridge and the inner wall of the housing) are disposable and can be replaced.

In some embodiments, the implementation of the device may be designed to create a smoke effect during use, for example, allowing vapors to exit the device. Optionally, vapors are generated from the heated starting material and/or from an added substance, such as propylene glycol (PG) and/or vegetable glycerin (VG).

In some embodiments, the following can be used to provide an electronic cigarette that is equivalent to a conventional cigarette.

Approximately 20 mg of tobacco may be heated per delivery event. Optionally, the entire source material may be sufficient for 10 to 15 delivery events, with each delivery event including, for example, one breath. Optionally, the starting material is in the form of a strip with a thickness of 0.5 mm and/or another structure. Optionally, the starting material is covered with sheet perforated foil on the upper and lower surfaces of the strip.

In some embodiments, an electrical power source in the form of a battery or a hybrid of a supercapacitor and a battery is used to supply electrical power to each 20 mg starting material section. Optionally, the power supply is designed to supply enough electricity for one electronic cigarette. Alternatively, the power supply is designed to supply sufficient electricity for a plurality of electronic cigarettes. In one example, the battery is designed to deliver at least 4 watts, at least 3 watts, at least 6 watts, or some other higher or lower value of electricity per 1 mg of heated tobacco. Optionally, the battery is rechargeable. Optionally, the battery is disposable. Examples of commercially available batteries suitable for use in the device described in this document may include:

a. LiPo - lithium polymer; a battery of two consecutive batteries; a suitable battery is, for example, SLPB503435H4 from KoKam;

b. nanophosphate powerful lithium-ion battery ANR26650 company A123 and

c. hybrid supercapacitor and lithium-ion battery. The supercapacitor pulses power to the cartridge, while the battery charges the capacitor between uses. An example of a suitable supercapacitor is the Maxwell BCAP10350.

In another example, 20 mg of a mixture of ground tobacco and cannabis fluff can be used. In some embodiments, one dose comprises 10 mg to 50 mg ground plant material. Optionally, this dose is leveled so that its width perpendicular to the heating element is 0.5 - 1.5 mm. Some examples, but not limitation, include 20-40 mg of tobacco and/or cannabis and a mixture of 15 mg of tobacco and 25 mg of cinnamon with an evaporation temperature of, for example, 265°C.

In some embodiments, the amount of active substance delivered to the user from the starting material of one section is equivalent to the amount of active substance inhaled in one breath when smoking a conventional cigarette, for example, comprising 50-150 μg of nicotine. Optionally, this amount varies according to the concentration of the active substance in the starting material and the extraction efficiency of the device (calculated according to the amount of starting material and the amount of active substance delivered), which can be, for example, 10% - 85%, or 30% - 80%, or 40% - 75%, such as 40%, 60%, 75%, or somewhere in between, higher or lower. For example, with an extraction efficiency of 50%, each section can contain 100 - 300 micrograms of nicotine. In embodiments where the device corresponds to a conventional cigarette that can be smoked in approximately 10 to 12 puffs, the device may contain 1 to 3.6 mg of nicotine. Because the nicotine content can vary between different types of tobacco, the amount of tobacco can vary. In the first example, tobacco contains approximately 25 mg of nicotine per 1 g of tobacco. In the second example, tobacco contains approximately 15 mg of nicotine per 1 g of tobacco.

In some embodiments, the amount of starting material is equivalent to that contained in one or more conventional cigarettes. In one example, one cartridge contains sufficient starting material for 50-120 delivery events (delivered in 50-120 breaths or more) and corresponding to approximately 5-10 cigarettes depending on the nicotine content. For example, for tobacco having the aforementioned reduced nicotine content, the total amount of starting material may be 1.25 - 2.5 g of tobacco. For tobacco with a high nicotine content, the total amount of starting material can be 125 - 250 mg of tobacco. Optionally, when using tobacco with a relatively high nicotine content, the total amount in the cartridge can correspond to a larger number of cigarettes.

In some embodiments, the starting material comprises approximately 1-10%, 3-7%, 5-8%, 10-20%, or other intermediate higher or lower amount of nicotine.

In some embodiments, each starting material section comprises at least 5, 10-20, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 30, 40, 50 mg, or more high or lower amount of tobacco.

In one example, each stock section contains 15 mg of organic material such as tobacco or cannabis. Optionally, in this case, the cartridge, including 10 sections of the source material, contains a total of 150 mg of organic material.

It should be noted that materials other than tobacco may be used, and the amounts indicated herein may be applicable to other plant materials. Alternatively, if a synthetic and/or extracted and/or purified agent is used, even higher concentrations of the active agent can be provided and there may be more delivery events for a single feed cartridge.

On FIG. 13A-B show the device 1308 shown as an example in FIG. 12A-E, which includes a usage progress indicator, according to some embodiments.

In some embodiments, the device includes a usage progress indicator for indicating one or more of: the amount of starting material consumed, the remaining amount of starting material, that all of the starting material has been used up or approximately used up, and/or other parameters.

In this document, the source material (or amount of source material) is considered consumed when the device has already consumed the source material (for example, by heating and / or by passing air through it) and / or when the device is intended not to use the source material (even if no active substance is inhaled from it). Optionally, the signal indicates that a certain portion of the starting material has been consumed. For example, if the device is loaded with a source material that includes tobacco or nicotine to replace a plurality of cigarettes, there may be a separate indication that the amount of source material corresponding to one cigarette has been consumed, allowing the user to adjust the frequency of use.

In some embodiments, such an indicator is designed to provide a visual and/or audible and/or tactile and/or perceptible signal to the user. In one example, the indicator uses a source material odor released only during the last delivery event and/or the last 2-3 breaths. In another example, the indicator turns on the light tube. Optionally, the heat causes the tube material to deform so that the light transmission changes (eg transparent plastic turns whitish due to heat) indicating the progress of use to the user. In some embodiments, the indicator is designed to indicate (eg, by changing color and/or changing light intensity) the remaining active agent in the dose currently consumed and/or in the source material section currently being used. In one example, when the user navigates to a specific source material section, the indicator light turns on. The indicator glows dimly or flickers when the user inhales (in one or more breaths) to indicate the approximate amount of active agent remaining in this section. In one example, a high concentration and/or a large residual amount of an active agent may be indicated by one or more of: high light intensity, which decreases during use, high flicker frequency, which slows down during use, a gradual change in the color of the indicator (for example, from red to black). Optionally, after loading the next dose, the indicator returns to the state before inhalation, for example, light passes through the indicator, returning the indicator state to maximum brightness.

In some embodiments, the amount of active agent remaining in a section is calculated from one or more of: the amount and/or concentration of active agent in that section, the amount of starting material in that section, the number of breaths of the user that the active agent (or agents) was extracted from this section, the air flow during inhalation, the suction force generated during inhalation, the period of time for which this section was heated, the temperature to which the source material was heated, and/or the flow rate of air passing through this section.

In some embodiments, the indicator light is initially turned on at a low brightness and/or with a specific color, and the brightness increases and/or the color changes with continued inhalation and/or in response to the suction force generated by the inhalation. Optionally, the light returns to a low intensity state and/or to a base light after inhalation is terminated.

In some embodiments, such as the one shown in FIG. 13A-B, indicator 1300 includes a light and/or color indicia. Optionally, the indicator 1300 is designed to move in accordance with the loading mechanism of the device, for example, to move along with the carriage shown for example in FIG. 12A-E (1214). Optionally, the indicator moves from the distal end 1302 of the device to the proximal end 1304 where the mouthpiece 1306 is located. Optionally, the device body includes informative marking (not shown) of one or more positions of the indicator 1300. In some embodiments, the physical position of the indicator indicates the remaining sections with source material and/or spent sections with source material.

On FIG. 14 is a flow diagram of a general method for delivering at least one substance released from a source material to a user, in accordance with some embodiments of the invention.

In some embodiments, one or more feed sections from a plurality of feed sections are selected (1400) for use. Optionally, this one or more sections is selected automatically by the controller of the inhalation device. Additionally or alternatively, this one or more sections is selected by the user, for example, using a mechanical and/or electrical drive (eg, a disk, slider, switch, and/or other devices). Optionally, sections are selected sequentially in the order determined by their spatial arrangement in the device.

In some embodiments, different feed sections include different types of materials. Optionally, different types of plant materials are used, including, for example, tobacco, cannabis, and/or other plant materials, such as those mentioned herein above.

In some embodiments, the implementation of different sections with the source material include different compositions of substances.

In some embodiments, different feed sections include different amounts of actives, e.g., nicotine, THC, and/or other cannabinoids and/or alkaloids, and/or other actives, including, e.g., 1,2,3,4- tetrahydroisoquinolines, anabazine, anatabine, cotinine, myosmin, nicotrine, norcotinine and/or nornicotine.

In some embodiments, the implementation of the sections with the source material is located in the space of the cartridge according to their contents. For example, each of the sequence of sections with the source material includes a different amount of active agent, while the sections are located so that the amount of active agent varies along the cartridge (for example, decreases and/or increases along the cartridge). Optionally, the change refers to the composition of the actives, for example the amount of aroma and/or flavor actives in addition to a fixed or varying amount of another active (eg nicotine, THC and/or any other alkaloid or cannabinoid). Alternatively, the amount of active agent in each of a plurality of feed sections is constant.

In some embodiments, the implementation of the schedule and/or order of delivery of different materials and/or different amounts of active substances to the user is determined by the spatial arrangement of the sections with the source material relative to each other. Optionally, the sections are used according to their spatial arrangement. Alternatively, the sections are used in an order that is independent of their spatial arrangement. Optionally, the sections are used in the order specified by the user. Optionally, the controller determines the order in which the sections will be used, based on input and/or input from the user. Alternatively, the sections are used in the given order.

In some embodiments, one section is divided into a plurality of subsections, such as 2, 3, 5, 10 subsections. Optionally, only a portion of the subsections is selected for use.

In some embodiments, a subgroup is selected from a plurality of starting materials. Optionally, with each breath and/or each session of use of the device (such as a session of use involving a plurality of breaths), a different subset of sections is selected for use.

In some embodiments, an airflow channel is created between one or more selected feed sections and the user outlet (1402). In some embodiments, creating an airflow duct includes changing the state of an existing duct that leads to the selected section from a state in which airflow cannot flow through the duct to a state in which at least a portion of the airflow can flow through the duct. In some embodiments, the change includes generating a fluid communication between the selected feed section and the user, for example, by unlocking the channel, aligning displaced portions of the channel, switching a valve, and/or other actions appropriate to create air flow to the source material of the selected section, and through it to this channel and to the user.

In some embodiments, after the air flow can pass through the source material, at least one active substance is released from the latter (1404). Optionally, the active substance is released by evaporation of the starting material. In some embodiments, a heating element associated with the source material section is turned on to heat the source material in the selected section, such as by electrically connecting the heating element to a power source.

In some embodiments, the heating of the source material and the creation of a channel for air flow occur in a coordinated manner. Optionally, heating starts before the air flow (e.g. up to 2 min, 1 min, 30 s, 25 s, 20 s, 15 s, 10 s, 5 s, 2 s and/or another intermediate, longer or shorter period of time up to start of air flow Optionally, heating can be completed before the air flow channel is created.

Alternatively, heating starts after the airflow channel is created, for example, 1ms, 10ms, 500ms, 1s, 5s, 10s or less after the airflow channel is created.

Optionally, the heating starts before the creation of the air flow channel and increases after the creation of the air flow channel.

Additionally or alternatively, heating is initiated or increased in response to user input, such as in response to inhalation through the device.

In some embodiments, the creation of the airflow channel (eg, by unblocking the airflow channel) and the source material heating schedule are coordinated by the controller of the inhaler device. Optionally, the controller is programmed with one or more protocols in accordance with one or more of: the type (or types) of starting material used, the type (or types) of active substance to be recovered, the profile and needs of the user, and so on.

In some embodiments, the heating schedule is determined by monitoring the airflow, for example in response to a reading from a flow sensor, pressure sensor, and/or other flow-related reading. Optionally, heating starts or increases automatically in response to a flow related reading from one or more sensors. Additionally or alternatively, the heating is started or increased manually by the user of the device.

In some embodiments, the released (eg, vaporized) substance is then delivered to the user (1406). Optionally, the air drawn into the inhaler, optionally in response to the user's inhalation, passes through the source material in the selected section, into the airflow channel that has been created, and towards the user, for example through the mouthpiece. In some embodiments, the airflow reaching the user includes ambient air that has been drawn into the inhaler and saturated with vapor of the released active agent. Optionally, the airflow channel is insulated so that once the air has passed through the section, it can only exit the device through the mouthpiece. Optionally, the air stream containing the substance can only exit the device while the user is inhaling.

In some embodiments, once one or more feed sections have been used, their associated airflow channels are closed. Alternatively, the air passed through the used source material section (eg, through the air flow channel of the source material section currently in use) may come into contact with the used source material.

In some embodiments, a cartridge is provided that includes a plurality of feed sections and, optionally, at least a portion of associated airflow channels, the cartridge being designed to be installed in and/or otherwise operably connected to an inhalation device. In some embodiments, the implementation of the cartridge includes an exit to the user, for example in the form of a mouthpiece. In one example, a tube-shaped mouthpiece is used, optionally tapering towards the user to facilitate suction. In some embodiments, the cartridge includes an actuator for unblocking the respective flow channels of one or more selected feed sections and/or for turning on the heating of the feed in one or more selected sections.

On FIG. 15A-B schematically show selective unblocking of an airflow path associated with a selected feed section, in accordance with some embodiments.

In some embodiments, such as the one shown in FIG. 15A, there are a plurality of source material sections 1500, 1502, 1504. Optionally, each source material section is associated with a respective airflow path 1506, 1508, 1510 extending between that source material section and outlet 1512 to user 1514. Optionally, a plurality of airflow channels are connected to form one airflow channel before exit 1512. The multiple airflow channels in FIG. 15A are shown in a blocked state in which no air flow can pass through them.

In some embodiments, during use, such as shown in FIG. 15B, at least one airflow channel, such as 1506, is modified to allow airflow 1516 through. channel. In some embodiments, for example, after using the source material section, the airflow channel 1506 can be blocked again, for example by moving the blocking element 1518 to the blocked position.

In some embodiments, each feed section is associated with a heating element for heating at least a portion of the feed in that section. In some embodiments, the implementation of the heating element is located in contact and/or in sufficient proximity to the source material to ensure heating of the source material to a temperature sufficient to vaporize at least one active substance of the source material. In one example, the heating element includes a mesh that contacts the material at least partially. Optionally, the mesh defines at least one wall 1520 of the feed section. Optionally, the mesh includes openings through which air can flow to and/or through the parent material. Heating elements, such as those described herein above, may be used in addition to or alternatively to the grid.

For example, in some embodiments, the heating element may be made from or include one or more of the following electrically resistive materials: semiconductors such as doped ceramics, conductive ceramics (such as molybdenum disilicide), carbon, graphite, metals, metal alloys, and composite materials made of ceramic material and metal material. Such composite materials may include alloyed or unalloyed ceramics. Examples of suitable doped ceramics include doped silicon carbides. Examples of suitable metals include titanium, zirconium, tantalum and the platinum group metals. Examples of suitable metal alloys include stainless steel, alloys containing nickel, cobalt, chromium, aluminium, titanium, zirconium, hafnium, niobium, molybdenum, tantalum, tungsten, tin, gallium, manganese and iron, as well as high temperature alloys based on nickel, iron , cobalt, stainless steel, Timetal® and iron-manganese-aluminum alloys. Other materials may include silver, platinum, copper, nickel and palladium.

In some embodiments, a plurality of feed sections are separated from one another by an airtight barrier, such as including a wall 1522. Optionally, the airtight barrier can be removed or moved, for example, to allow access to two feed sections at the same time.

In some embodiments, the source material section, such as 1500, is fixed relative to the device body 1524. Optionally, there is no relative movement between the feed section and the heating element 1520; there is no relative movement between the section with the source material and the associated channel for air flow 1506; and/or there is no relative motion between the source material section and one or more device components, such as the outlet 1512 (eg, mouthpiece).

In some embodiments, the source material layer in each section has a thickness of no more than 1 mm, no more than 0.5 mm, no more than 2 mm, no more than 5 mm, or other thickness in between, greater or lesser. For example, the layer may be 0.5 - 5 mm, or 0.5 - 2 mm, or 0.5 - 1.5 mm along the path of air flow through the material.

On FIG. 16A-B show an isometric view (16A) and a side view (16B) of an arrangement of source material sections configured to provide separate access to each of a plurality of source material sections, in some embodiments.

In some embodiments, the location 1600 includes a number of sections with source material 1602. Optionally, the sections are linearly aligned with each other, such as shown herein. It should be said that other arrangements and/or spatial distributions of a plurality of sections are also possible. In some embodiments, each section 1602 may be accessed by lifting, sliding, and/or otherwise moving a cover 1604 that blocks the passage of air to and through the feedstock in and through the section. In some embodiments, movement of the lid is by magnetic means, manually or electrically. In some embodiments, the cover 1604 is rotatably connected to the hinge.

In some embodiments, the air that passes into the open section of the source material passes through the source material and into the channel (the opening of which is shown at position 1606) for delivery to the user. Optionally, the channel is a shared channel for a plurality of source material sections.

On FIG. 17A-B show a movable actuator 1700 for unlocking at least one airflow passage associated with at least one feed section and/or for turning on a heating element associated with at least one feed section, according to some embodiments of the invention.

In some embodiments, the actuator 1700 moves along the housing 1702, such as along the long axis of the housing, i.e., in the direction shown by arrow 1704, to provide access to one or more selected feed sections in the housing 1702. In some embodiments, the actuator 1700 is designed to slide the cover (such cover 1604, mentioned in this document above) of the corresponding section with the source material.

In some embodiments, actuator 1700 is configured to turn on a heating element associated with the feed section, such as by electrically connecting the heating element (such as a conductive grid) to a power source, such as a battery.

Additionally or alternatively, in some embodiments, the electrical connection is made in response to inspiration.

Optionally, the electrical circuit is closed in response to the detection of a flow-related parameter (eg, pressure or pressure change). Additionally or alternatively, the electrical circuit is completed by the movement of the damper, valve and/or other mechanical element that moves in response to the air flow. In some embodiments, inhalation initiates electrical connection and heating by changing the position of a mechanical element, such as a leaf or spring, completing an electrical circuit when propelled by sufficient airflow. Other examples of such mechanical elements include bimetal switches that are responsive to air flow, an electromechanical generator that generates electrical power as a result of the flow, and/or other suitable devices.

In some embodiments, inhalation acts as a trigger for a physical and/or electronic sensor for, but is not limited to, lip conductance, lip temperature, pressure change due to inhalation, characteristic accelerations caused by movement relative to the earth's gravity, proximity sensors, and/or light sensors. In some embodiments, breath detection is performed by a mechanical element, such as a petal or spring, that changes its position to complete an electrical circuit when moved by sufficient airflow. Optionally, mechanical airflow detection is performed in conjunction with electrical and/or electromechanical elements such as conductivity sensors and/or bend sensors. Other examples include bimetal switches that are responsive to air flow, an electromechanical generator that generates electrical power as a result of the flow, and/or other suitable devices and/or sensors.

In some embodiments, an actuator is used to connect an electrical circuit to make the aforementioned connection, such as through spring contacts, spade connections, direct galvanic connection, and/or the like.

In some embodiments, the electric heater is turned on based on a change in airflow, such as WO2013060784, which is incorporated herein by reference. For example, any sensor that can track airflow can be used. Any electromechanical device can serve as a sensor. Alternatively, the sensor may be any one of a mechanical device, an optical device, an optomechanical device, a microelectromechanical system (MEMS), and an acoustic sensor. The sensor can be a thermal conductometric flow sensor, pressure sensor, anemometer. Optionally, the sensor may be capable of not only monitoring the airflow, but also measuring it. The sensor may be designed to deliver an analog electrical signal or digital data that represents the amplitude of the air flow.

In some embodiments, movement of actuator 1700 is performed manually (eg, by a user). In some embodiments, the user moves the actuator 1700 before and/or during use of the device. A potential advantage of a user-controlled drive may include the ability for the user to control the rate and/or duration and/or amount of active agent delivered.

Alternatively, the movement of the actuator 1700 is automatic, eg according to a predetermined protocol.

On FIG. 17A shows the first side of the device on which the actuator 1700 travels; in FIG. 17B shows a second, opposite side of the device, including a plurality of slots 1706 through which air enters the device. Air entering the device can enter the feed section after the corresponding airflow channel (not shown in this example) is unblocked.

On FIG. 18A-D show various actuator design features such as those shown in FIGS. 17A-B, according to some embodiments.

In some embodiments, the actuator is configured to move the feed section cover using magnetic attraction. Optionally, as shown, for example, in FIG. 18A, the actuator includes one or more magnets 1800 having a size, position, and magnetic force sufficient to move a magnet-attracted feed section cover. On FIG. 18B shows the actuator design without magnets.

In some embodiments, such as the one shown in FIG. 18C, the actuator includes electrical connectors 1802 for completing an electrical circuit or becoming part of the electrical circuit of the feed sections when the actuator is in a certain position. In some embodiments, the completion of the electrical circuit includes a heating element to heat the source material of the selected section. In some embodiments, the implementation of the circuit can be closed only after sliding the cover of the selected section with the source material. In some embodiments, the circuit may be closed only after the air flow commences or exceeds a certain threshold.

In some embodiments, the drive is shaped and/or sized to fit on a housing that encloses the feed sections. In one example of this document, the actuator has a rectangular profile sized to overlap the housing. It should be noted that the actuator may be of any other shape suitable for engaging the blocking element of the section with the source material during movement and/or other movement of the actuator to unlock the element.

In some embodiments, such as the one shown in FIG. 18D, the actuator includes one or more structural elements that are shaped to facilitate gripping of the actuator by hand, such as ribs 1804.

On FIG. 19A-B show a cam mechanism for sequential use of a plurality of feed sections, in accordance with some embodiments of the invention. In some embodiments, the camshaft 1900 extends along at least a portion of the feed section 1902 into position. suitable for sliding covers of feed sections (lids not shown). In some embodiments, the camshaft cams 1906 extend to engage with the lids such that as the camshaft rotates, the lids are lifted one by one by the cams, thereby allowing air to pass into and through the open section parent material.

On FIG. 20 shows deformable areas for selectively accessing one or more source material sections, in some embodiments. In some embodiments, the panel 2000 covers a number of feed sections (not shown). In some embodiments, the panel includes a plurality of access areas 2002 at different locations of the source material sections. In one example, the access area 2002 is located directly above the source material section. In some embodiments, access portion 2002 includes a portion that is less durable than the surrounding panel material such that it can be removed, perforated, and/or otherwise deformed to allow air to pass through. In some embodiments, the access site includes a perforated and/or etched layer.

In some embodiments, the access site is made of magnetic material and/or includes magnetic material such that it can be removed by pulling a magnet, such as moving a magnetic actuator, such as described herein above. Optionally, when the magnetic force is no longer applied (eg, when the drive is moved further), the access section returns to its original closed state.

In some embodiments, the access site includes one or more of: magnetic materials, stainless steel, iron sheet, nickel, ferrous metal foil, and/or others.

On FIG. 21A-C show a mouthpiece for use with a number of feed sections, in some embodiments. In some embodiments, the mouthpiece 2100 (shown in the front view in Fig. 21A and in the back view in Fig. 21B) is designed to be attached to the frame 2102 (shown in Fig. 21C) of a number of feed sections (not shown here). Optionally, the mouthpiece 2100 is detachably attached to the frame 2102, for example, so that it can be washed and reinstalled. Additionally or alternatively, the mouthpiece 2100 is disposable.

In some embodiments, a seal, such as in the form of an o-ring (not shown), is located at the attachment of the mouthpiece to the frame to provide fluid communication.

On FIG. 22 is a cross-sectional view of the location of a plurality of feed sections and their respective air passages, in some embodiments.

In some embodiments, the source material is contained in a plurality of slots 2200 formed in the substrate 2202. In some embodiments, one or more airflow channels, such as a channel 2204, extend from the slot 2200 to the central airflow outlet 2206.

In some embodiments, the implementation of the actuator, for example in the form of a rotary switch, which is described in this document below, is located at the outlet 2206 air flow. Optionally, duct 2204 is unlocked to allow air to flow through the duct to and through the parent material of the selected slot and through that parent material by aligning the opening of the rotary switch with the distal opening of duct 2204.

In some embodiments, such a switch simultaneously closes the electrical circuit of the selected slot with the source material to turn on the heating of the source material. Additionally or alternatively, in some embodiments, the electrical connection is made in response to inspiration. Optionally, the electrical circuit is closed in response to the detection of a flow-related parameter (eg, pressure or pressure change in response to the user inhaling through the device). Optionally, closing the electrical circuit turns on the heating. Optionally, the electrical circuit is closed mechanically by the air flow.

In some embodiments, the heat vaporizes the source material and air saturated with at least one active agent flows through the airflow outlet 2206 to be delivered to the user (e.g., via one or more additional channels and a mouthpiece - not shown here).

In some embodiments, substrate 2202 is a printed circuit board with circuitry associated with feed slots. Optionally, the printed circuit board is flexible. In some embodiments, substrate 2202 may include a removable board and/or free form using adhesive (terminal mounting). In some embodiments, substrate 2202 includes heat resistant materials and/or inert materials such as Kapton, polyimide, mica foil, and/or others.

On FIG. 23 is an outside view of the arrangement shown as an example in FIG. 22, according to some embodiments.

This figure shows a housing 2300 including the arrangement shown, for example, in FIG. 22. For illustrative purposes, empty slots 2302 with source material are shown on the right side of the body, and slots 2304 covered with mesh (optionally already loaded with source material) are shown on the left side of the body 2300.

On FIG. 24A-B show examples of a rotary actuator for use with the arrangement shown as an example in FIG. 22, according to some embodiments.

In some embodiments, rotary actuator 2400 includes a calibrated orifice 2402 through which air can flow. Optionally, as the actuator is rotated, the calibrated port 2402 aligns with the far port of the airflow path leading to the feed section (eg, the feed slot described above herein).

In some embodiments, the drive includes electrical connections to complete the circuit with the selected feed section. Optionally, the electrical connections include spring leads and/or other spring-loaded contacts suitable for making a temporary electrical connection to the circuitry for the selected feed slot.

On FIG. 25A-C show an apparatus including an arrangement in some embodiments similar to that shown in FIG. 22.

In the cross sectional view in Fig. 25C, a substrate 2500 (eg, a printed circuit board) can be seen including a plurality of source material slots 2502 and associated channels 2504. In this example, slots 2502 are arranged in a different geometry than in FIG. 22. Central airflow outlet 2506 including distal duct openings 2508 according to some embodiments is shown without rotary actuator. On FIG. 25B shows rotary actuator grip 2510 projecting outward from substrate 2500, with actuator located at airflow outlet 2506. Coating 2512 is layered on substrate 2500 to block the openings of slots 2502, in some embodiments, from at least one direction. In some embodiments, distal ports 2508 are locked and selectively opened by an actuator, such as rotary actuator 2400, shown as an example in FIG. 24A-B.

On FIG. 25A shows a fully assembled device according to some embodiments. In some embodiments, the outer housing 2514 includes one or more marks 2516 to indicate to the user the position of the rotary actuator 2510.

On FIG. 26 shows an alternate arrangement of a plurality of feed sections and their respective air passages, in some embodiments. In this example, all of the feed slots 2600 made in the substrate 2602 are aligned linearly with each other. In some embodiments, such as those shown herein, an airflow outlet 2604 is located at the proximal and/or distal end of the substrate. Air flow channels 2604 are shown extending from their associated feed slots to an air flow outlet 2604.

Some embodiments may include more than one main airflow outlet, such as 2, 3, 5 airflow outlets.

On FIG. 27A-C show the movement of a parent material coating using a shape-changing element, in accordance with some embodiments of the invention.

In some embodiments, the shape-changing member includes one or more shape memory materials that deform in response to a change in temperature.

In some embodiments, the shape-changing member, such as the transformable body 2700, may slide, lift, and/or otherwise move the feed section cover 2702 to allow airflow to pass through. In some embodiments, the transformable body 2700 may deform in response to a change in temperature, such as expand, bend, and/or straighten in response to a rise in temperature. In some embodiments, the transformable body 2700 is designed to return to its original shape in response to cooling. In some embodiments, the transformable body 2700 is adjacent to and/or in contact with or at the location where it is to interact with the heating element 2704 of the source material section. Optionally, when the heating element 2704 is turned on, for example by closing an electrical circuit, the transformable body 2700 expands in one or more directions to thereby move the cover 2702 into a position in which air flow can pass through the source material, as shown, for example, in Fig. 27b. In this example, transformable body 2700 expands longitudinally (i.e., along an axis substantially perpendicular to lid 2702 when lid 2702 is closed) in response to heat, while raising at least a portion of lid 2702.

In some embodiments, the shape-changing member is designed to move, fold, perforate, slide, and/or otherwise act on at least a portion of the feed section cover. In some embodiments, the shape-changing element includes polyurethane foam, shape memory polyurethane, polymers, silicone, thermosets with suitable melting points such as wax, and/or other materials that change their state and/or shape in response to change. temperature.

In some embodiments, the flow of air through the device (eg, in response to inspiration) causes a temperature change that affects the shape-changing element.

In some embodiments, one or more mechanical elements such as a spring, tab, pin, and/or others are used in addition to or instead of the shape-changing element to open the lid.

In some embodiments, closing the lid (eg, after using the parent material contained underneath) is accomplished using the same shape-changing element (eg, using a double-sided shape memory material). For example, cooling the transformable body 2700 causes it to return to its original shape and/or deform again into a shape that allows the lid to return to its original position. Additionally or alternatively, closing the lid is accomplished using another shape-changing element, such as using a second transformable body for closing the lid. Optionally, the opposite second transformable body expands or contracts with a delay relative to the first transformable body 2700 (e.g., after 0.5 s, 1 s, 3 s, 4 s, or other intermediate, longer or shorter period of time) to close the lid after using the section. Optionally, the delay is carried out by using a heat insulating material that slows down the transfer of heat to the second transformable body, and/or by using a fuse that blows when heat is applied.

Additionally or alternatively, the closing is effected by one or more mechanical elements, such as a spring, shaped, sized and positioned to counteract the expansion of the transformable body.

In some embodiments, the transformable body includes one or more shape memory materials, such as shape memory polymers (e.g., foam), thermal expansion components, where such component can vaporize, causing another component to expand, etc.

In some examples, the lid 2702 includes silicone foil.

On FIG. 28 is an isometric view of an inhaler device 2800 including linearly arranged feed sections with separate access, in some embodiments.

In some embodiments, each feed section includes a lid 2802 designed to be opened separately from another or more other lids. Optionally, the cover 2802 is opened by a shape memory mechanism. In some embodiments, the lid 2802 itself includes a shape memory material that deforms, moves, and/or otherwise changes shape or position, thereby allowing air to pass to and optionally through at least a portion of the parent material protected by the lid 2802.

On FIG. 29A-B are schematic plan views of an arrangement 2900 in which a fluid medium of varying viscosity is used to seal the feed, in accordance with some embodiments.

In some embodiments, a fluid that changes its viscosity in response to a change in temperature, such as silicone oil, seals the starting material without allowing air flow. Optionally, a variable viscosity fluid (shown in this figure as an opaque colored surface) is layered on a mesh or other scaffold 2902 surrounding the source material. On FIG. 29A shows an unheated (cold) state in which the fluid is high enough in viscosity to seal the starting material underneath, in accordance with some embodiments. On FIG. 29B shows a heated state in which the viscosity is reduced to allow fluid to flow through the capillary channels 2904 and into one or more side chambers 2906. In some embodiments, the flow of fluid from the parent material mesh or frame opens the parent material to air flow.

In some embodiments, a change in temperature creates a change in the surface tension of the fluid. Optionally, the change in surface tension and viscosity results in capillary movement of the fluid which opens at least a portion of the feedstock to air.

In some embodiments, upon cessation of heating and cooling of the fluid, the latter spontaneously moves back, closing the open area. Optionally, the fluid flows (eg, through capillary channels) due to changes in surface tension and/or wetting properties of the fluid.

On FIG. 30A-B schematically show an inhaler device for receiving a plurality of feed cartridges, in accordance with some embodiments.

In some embodiments, inhaler device 3000 includes a plurality of recesses, slots, receptacles, connectors, and/or other structures, each for receiving one or more source material cartridges. In the example shown, apparatus 3000 includes an empty receptacle 3004 and three feed cartridges 3006, 3008, 3010 installed in respective three receptacles. Examples of such cartridges may include the cartridges and/or devices described herein, such as those shown in FIG. 8A-8B, 9, 10A-10F, 11B, 12C-12D, 16A-16B, 22, 23, 26, 28 and 31A-31B.

In some embodiments, each cartridge includes a plurality of source material sections 3012. In some embodiments, such as shown as cartridge 3006, a plurality of source material sections comprise identical contents, such as the same plants or herbal compositions and/or the same and the same active substance or the same compositions of active substances. Alternatively, eg shown as cartridge 3010, different feed sections comprise different contents, eg different plants or herbal compositions and/or different actives or actives compositions.

In some embodiments, a particular cartridge and/or a particular feed section of the cartridge is accessed in a predetermined manner. Additionally or alternatively, the reference to a particular cartridge and/or a particular section of the source material in the cartridge occurs on demand, for example at the choice of the user according to his need and/or desire. In this example, in Fig. 30A shows selection of feed sections in cartridge 3006; in FIG. 30B shows the selection of feed sections in cartridge 3010.

In some embodiments, during use, the feedstock of one or more selected sections is heated (e.g., using a heating element as described herein above) and air 3014 that is drawn into and/or otherwise introduced into the device (e.g., through conduit 3018 ) can pass and/or be guided through the material of the selected section. Air 3015 saturated with the released active agent(s) is then delivered to the user through the device outlet 3016 (eg, including a mouthpiece). In some embodiments, active agent-laden air exits the inhaler in response to the user's inhalation. Additionally or alternatively, the device includes a fan or compressed air source (not shown) that can enhance and/or replace the user's inspiratory force.

In some embodiments, the selected sections differ in content such that different actives or compositions thereof are released from each section for delivery to the user. For example, in FIG. 30A, air 3015 saturated with the active agent(s) released from the source material section 3012 exits the inhaler device for delivery to the user; in FIG. 30B, air 3030 saturated with another active agent and/or another composition of active agents (compared to the active agent or composition released from section 3012 in FIG. 30A) is released from the source material section 3032.

In some embodiments, the device 3000 includes a controller 3022 for controlling selection and/or access to one or more specific feed sections and/or access to a selected cartridge. Optionally, two or more sections are accessed simultaneously to obtain a selected amount of active agent, a selected composition of active agents and/or a selected effect for the patient. Optionally, different air flow and/or heating modes are used for each of a plurality of sections accessed simultaneously, thereby affecting the composition or proportion of actives in the air flow to the user.

Optionally, the controller selects sections that are identical in content. Alternatively, the controller selects sections that differ in content. Optionally, the controller selects sections in one cartridge. Alternatively, the controller selects sections from different cartridges.

In some embodiments, the controller 3022 is configured to select a section of source material to use in a predetermined order, such as according to some mode.

In addition to or alternatively to a controller, device 3000 includes a manual control (eg, an actuator such as a slider) for selecting a section and/or turning on the heating of the selected section and/or for accessing the selected section.

In some embodiments, the implementation of the controller and/or body of manual control is designed to "mix and match" different sections of the source material for their content.

In some embodiments, the implementation of several sections of the source material have content that is different from one another and is selected for the treatment of a particular medical condition. Examples of compositions of active substances and medical conditions that can potentially be treated using such active substances may include: active agents that give a synergistic effect, active agents that give the same effect, but each of which has its own advantages or disadvantages, active agents that enhance or weaken each other or other active agents (e.g., change each other's effective therapeutic window or therapeutic index), active agents that have the opposite effect, such as cannabidiol (CBD) antagonizes tetrahydrocannabinol (THC), and active agents that have opposite effects. , but desirable, effects and should be kept separately.

Some combinations of active agents that can be effectively delivered by devices provided herein according to embodiments of the present disclosure include, but are not limited to, nicotine and THC, caffeine and THC, and CBD and THC. Some combinations are intended for recreational use and may include combining or substituting different bags of tobacco, tobacco with different additives, different strains or blends of cannabis, different plant material from other plants, and any combination of these.

In some embodiments, selection of multiple feed sections is performed with precise control of the amounts of actives, such as by using different feed sections that contain different amounts of active. For example, a first starting material section containing 5 mg of active may be used together with a second starting material section containing only 1 mg of active to give an accurate total of 6 mg of active.

In some embodiments, the device 3000 includes a communications module 3024. Optionally, the communications module is configured to send and/or receive data from one or more user input devices, a database, a memory, an online data source, a clinician, and/or others. Optionally, the selection of the section (or sections) with raw materials to use is carried out according to instructions received through the communication module. In some embodiments, the data received from the user input device includes feedback data regarding the effect of the treatment. Optionally, the feedback data comes from one or more sensors of the user input device. In some embodiments, the implementation of the treatment is controlled (eg, adjusted according to a given regimen) according to the received feedback data.

On FIG. 31A-B is a schematic diagram showing the airflow pattern through an apparatus including a plurality of feed sections, in accordance with some embodiments.

In some embodiments, the device 3100 includes one or more air inlets 3102 through which incoming air 3112 that enters the device flows to and through the open feed section 3104. As shown, stream 3130 saturated with the active agent from the source material passes from section 3104 through a transport channel 3103 that reaches the mouthpiece 3106 for delivery to the user. In some embodiments, the device includes a bypass channel 3108 that connects to the transport channel 3013 without passing through the source material, for example, connects at 3105. Alternatively, in some embodiments, the bypass channel 3108 extends directly into the mouthpiece 3106, separate from the transport channel 3103 .

In some embodiments, the implementation of the valve 3110 is located on the opening of the bypass channel and regulates the flow entering the bypass channel. In use, the bypass flow is adjusted in response to airflow through the device (eg, through a selected feed section(s)). Optionally, as shown in FIG. 31A, when the flow rate of the incoming air flow 3112 is within the specified limits, the valve 3110 remains closed. If the input airflow rate becomes higher than the threshold value, as shown in FIG. 31B, the valve 3110 opens to direct at least a portion 3132 of the incoming air stream 3112 into the bypass. In some embodiments, the flow rate, velocity, volume, and/or pressure of the incoming air flow is determined by the sensor 3114.

In some embodiments, inspiration below the threshold will not trigger heating of the source material. Optionally, in such a situation, a warning (eg, an optical and/or audible and/or tactile indication) is given to the user to increase the inspiratory effort.

In some embodiments, the device 3110 is self-contained. Alternatively, the device 3110 is a cartridge that fits into an inhaler device. Optionally, in the latter (i.e., device 3110 is a cartridge), bypass channel 3108 (with or without valve 3110 and/or sensor 3114) is part of the inhalation device rather than the cartridge. Alternatively, the bypass channel 3108 is part of the cartridge.

In some embodiments, valve 3110 operates automatically, such as under the control of a controller. Optionally, the position of the valve 3110 is set in accordance with the indication related to the flow, which is received from the sensor 3114. Additionally or alternatively, the valve 3110 opens mechanically at a given flow rate.

The terms "include", "including", "includes", "having" and their derivatives mean "including but not limited to".

The term "consisting of" means "including and limited to".

The term "consisting essentially of" means that a composition, method, or design may include additional ingredients, steps, and/or details, but only if such additional ingredients, steps, and/or details do not materially change the basic and new characteristics of the claimed composition, method, or design. .

As used herein, the singular form includes references to the plural unless the context clearly indicates otherwise. For example, the term "compound" or "at least one compound" may include a variety of compounds, including mixtures thereof.

In the text of the present application, in various embodiments of the present invention, the values may be presented in interval format. It should be understood that the indication in the interval format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the invention. Accordingly, an indication of an interval is to be taken as specifically indicating all possible smaller intervals and individual numerical values within that interval. For example, specifying an interval of 1 - 6 should be considered specifically indicating smaller intervals such as 1 - 3, 1 - 4, 1 - 5, 2 - 4, 2 - 6, 3 - 6, etc., as well as individual numbers in this interval, for example, 1, 2, 3, 4, 5 and 6. This applies regardless of the width of the interval.

When a numerical value is specified in this document, it means that it includes any number (fractional or integer) in the specified range. The phrases "from ... to" the first specified number and the second specified number in various forms are used interchangeably herein and include the first and second specified numbers and all fractional and integer numbers in between.

As used herein, the term "method" refers to a procedure, means, techniques, and operations used to solve a problem, including, but not limited to, procedures, means, techniques, and operations that are either known or can be readily developed from known order, means, techniques and operations by practitioners in the chemical, pharmacological, biological and medical industries.

As used herein, the term "treatment" includes abolishing, substantially inhibiting, slowing or reversing the progress of a condition, substantially reducing the clinical or perceived symptoms of the condition, or substantially preventing the onset of the clinical or perceived symptoms of the condition.

It should be understood that certain features of the invention, which are indicated in the context of separate embodiments for clarity, may also be presented in combination in one embodiment. Conversely, various features of the invention, which for brevity are indicated in the context of one embodiment, may also be presented individually, or in any suitable combination, or suitable for any other described embodiment of the invention. Certain features indicated in the context of various embodiments should not be considered essential features of those embodiments unless the embodiment operates without those elements.

Claims (27)

1. Cartridge with the starting material for the delivery of the active substance by inhalation, containing: an elongated body containing sections along the long axis of said body, each of said sections containing a source material containing at least one active substance capable of being released from said source material upon evaporation; while said source material is designed to provide a through flow of air; moreover, the mentioned source material in each of the said sections is protected by an airtight sealant; an actuator mounted in a sliding manner on said elongated housing, wherein said actuator is slidable along at least a portion of said long axis of said housing between regions of one or more of said selected sections, wherein said actuator is configured to locally open said sealant of one or more said selected sections for allowing air to flow through said feed to deliver at least one said active to a user; wherein said drive is additionally intended for: passing electric current through the heating element of each of said selected sections. 2. Cartridge according to claim 1, characterized in that said cartridge contains at least one channel through which air saturated with the active substance is directed to flow for delivery to the user. 3. Cartridge according to claim 1, characterized in that said drive is designed to perform function (a), and each section with the source material is connected to a dedicated heating element configured to heat said source material. 4. The cartridge according to any one of paragraphs. 1-3, characterized in that said sections with the source material are separated from each other by an airtight barrier. 5. Cartridge according to any one of paragraphs. 1-4, containing at least one shared channel passing along the mentioned sections with the source material. 6. The cartridge according to any one of paragraphs. 1-5, characterized in that the starting material inside at least one of said sections contains nicotine. 7. Cartridge according to any one of paragraphs. 1-6, characterized in that the source material layer inside each section contains an air-permeable solid pallet containing a single mass of granular substance, and the thickness of said pallet is not more than 1 mm. 8. The cartridge according to any one of paragraphs. 1-7, characterized in that said drive is designed to transmit electric current due to the content of a group of electrodes. 9. The cartridge according to any one of paragraphs. 1-8 comprising a progress indicator for indicating one or more of: the number of source material sections used, the number of source material sections remaining, the amount of source material remaining in the section, that all source material sections have been used up, and that a certain part of the sections with the source material has been used up. 10. The cartridge according to any one of paragraphs. 1-9, characterized in that said sealant is designed to perform at least one function selected from the group consisting of: a. opening as a result of heating; b. heating said starting material. 11. Cartridge according to any one of paragraphs. 1-10, characterized in that said sections with the source material are separated from each other by at least one of the thermal insulation and electrical insulation. 12. The cartridge according to any one of paragraphs. 1-11, characterized in that said housing comprises an elongated slot extending along at least said part of said long axis, and said drive is inserted into said slot and is slidable in the direction of its length. 13. Cartridge according to any one of paragraphs. 1-12, characterized in that said drive is slidable along said slot under the action of the user's hand. 14. The cartridge according to any one of paragraphs. 1-13, characterized in that said drive is designed to selectively direct the air flow into and through one or more of said selected sections. 15. Cartridge according to claim 14, characterized in that said actuator is designed to selectively direct the air flow into and through one or more of said selected sections by means of a nozzle that is configured to direct said air flow to one or more of said selected sections. 16. Cartridge according to claim 8, characterized in that said cartridge comprises an insulating element in the form of a longitudinally extending shelf, which is configured to separate said electrodes of said actuator. 17. Cartridge according to any one of paragraphs. 1-16, comprising a ratchet mechanism which is configured to move said actuator in one direction along said elongated housing. 18. Cartridge according to any one of paragraphs. 1-17, containing a light or color indicator made with the possibility of joint movement with the mentioned drive to indicate the remaining or used sections. 19. Cartridge according to any one of paragraphs. 1-18, characterized in that said cartridge is in the form of a flat strip. 20. The cartridge according to any one of paragraphs. 1-19, characterized in that said cartridge is in the form of a cigarette designed to be held by the user's hand.

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