RU2747660C1 - Method for personifying nutrition taking into account genetically determined factors - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method of nutrition personification is proposed, which includes the nutritive process, the selection of food products and their absorption to maintain life and health, the normal course of physiological processes of vital activity, to replenish the energy reserve and implement the processes of growth and development. The selection of food products is based on genetically determined factors: the immune system of the blood, the blood group and Rh factor, enterotypes, as well as gender. Food products are selected in stages. The blood group is determined by the amount of agglutinins α and β in plasma, agglutinogens A and B in red blood cells and the Rh factor is found. The method of polymerase chain reaction is used to determine the prevailing enterotype: enterotype No. 1 Bacteroides, enterotype No. 2 Prevotella, or enterotype No. 3 Ruminococcus. Foodstuffs that are difficult to digest in the established enterotype are removed from the diet.

EFFECT: invention provides for development of a highly effective method of personalized nutrition, taking into account genetically determined factors.

1 cl, 5 tbl

Description

The invention relates to the food industry and medicine, namely to the creation of personalized nutrition algorithms, taking into account genetically determined factors (the immune system of the blood - blood groups and Rh factor, enterotypes, as well as gender), which can serve as a scientific basis for the selection of products nutrition and the creation of personal nutrition diets.

The invention makes it possible to develop a highly effective method of personalized nutrition, taking into account the immune system of the blood (blood groups + Rh factor), gender (male or female) and enterotypes (enterotype No. 1 bacteroids - Bacteroides, enterotype No. 2 Prevotella - Prevotella or enterotype No. 3 Ruminococcus - Ruminococcus).

Known medical tables (diets) No. 1-15 according to Pevzner (food tables and diet), suggesting the selection of food products in accordance with the disease [1]:

- medical table (diet) No. 1 - for stomach ulcers and duodenal ulcers;

- medical table (diet) No. 2 - with atrophic gastritis, colitis;

- medical table (diet) No. 3 - for constipation;

- medical table (diet) No. 4 - for bowel disease with diarrhea;

- medical table (diet) No. 5 - for diseases of the biliary tract and liver;

- medical table (diet) No. 6 - for urolithiasis, gout;

- medical table (diet) No. 7 - for chronic and acute nephritis;

- treatment table (diet) No. 8 - for obesity;

- medical table (diet) No. 9 - for diabetes mellitus;

- medical table (diet) No. 10 - for diseases of the cardiovascular system;

- treatment table (diet) No. 11 - for tuberculosis;

- medical table (diet) No. 12 - for diseases of the nervous system;

- medical table (diet) No. 13 - for acute infectious diseases;

- medical table (diet) No. 14 - for kidney disease with the discharge of stones from phosphates;

- medical table (diet) No. 15 - for diseases that do not require special diets.

The disadvantage of treatment tables (diets) is, first of all, that these diets (tables) do not take into account genetically determined factors (the immune system of the blood - blood groups and Rh factor, enterotypes, as well as gender). The proposed diets are mainly aimed at stopping the acute form of the disease and the maximum possible stabilization of the existing condition. In therapeutic diets (tables), food is removed that can aggravate the condition of a sick person. At the same time, therapeutic diets, as a rule, are not able to lead to recovery without the use of highly specialized drugs and active methods of treatment.

The closest to the invention is [2] - the prototype is the process of nutrition (physiological act) - maintaining the life and health of a living organism with the help of food - the process of absorption of food by living organisms (including humans) to maintain the normal course of physiological processes of life, in in particular, to replenish energy reserves and implement growth and development processes; an integral part of metabolism.

The disadvantage of the prototype is the fact that they are all impersonal and do not take into account the individual characteristics of each specific person, which are determined by hereditary factors, and are clearly manifested in his phenotype: in particular, these are gender differences, differences in the immune system of the blood and the dominant intestinal microflora (enterotypes) ...

Thus, the technical problem to be solved by this invention is the development of a highly effective method of personalized nutrition, taking into account genetically determined factors (immune status of blood (blood groups and Rh factor), gender specificity (man or woman) and intestinal ecosystems (enterotype No. 1 : bacteroids Bacteroides, enterotype No. 2: Prevotella Prevotella or enterotype No. 3: Ruminococcus Ruminococcus).

The solution to the technical problem is achieved by the fact that the method of personification of nutrition, taking into account genetically determined factors, including the process of nutrition (physiological act) - the selection of food products and their absorption to maintain life and health, the normal course of physiological processes of life, in particular, to replenish the supply of energy and the implementation of growth and development processes differs in that the selection of food products is based on genetically determined factors: the immune system of the blood - blood groups and Rh factor, enterotypes, as well as gender, while food products are selected in stages, according to the following algorithm:

- determine the blood group by the amount of agglutinins (α and β) in plasma, agglutinogens (A and B) in erythrocytes and find the Rh factor;

- the compatibility of food components with the components of the blood immune system is determined by the isoagglutination reaction of the nation: α and β-agglutinins, A- and B-agglutinogens, as well as Rh ⁺ and Rr ^{- the} Rh factor;

- remove food products from the diet, the components of which cause an agglutination reaction with the components of the blood immune system;

- the prevailing enterotype is determined by the polymerase chain reaction method: enterotype No. 1 bacteroids - Bacteroides, enterotype No. 2 Prevotella - Prevotella or enterotype No. 3 ruminococcus - Ruminococcus;

- I remove hard-to-digest food products from the diet, according to the established enterotype:

for enterotype No. 1 with a universal protein-fat-carbohydrate diet, it is possible not to remove food products,

for enterotype No. 2 with a carbohydrate diet, the amount of foods high in proteins and fats is reduced,

for enterotype No. 3 with a carbohydrate-fat diet, the amount of foods with a high protein content is reduced;

- remove food products from the diet, the components of which cause inhibition of the synthesis of sex hormones:

for women - progestogens and estrogens,

for men - androgens.

The method is implemented as follows.

Characteristics of human blood groups (distribution of agglutinins in plasma and agglutinogens in erythrocytes) are presented in Table 1.

Agglutinin is an antibody that causes an agglutination reaction of blood cells, bacteria and a number of other antigenic particles. Agglutinins are found in blood plasma. Their presence in the blood determines the group affiliation. Thus, the presence of α-agglutinin is characteristic of blood groups 0 (I) and B (III), β-agglutinin is present in blood groups 0 (I) and A (II). This protein compound is one of the participants in the immune response. In the blood, there are also agglutinogens specific for blood group AB (IV), also present in blood groups B (III) and A (II), acting as compensation for the missing agglutinins.

- «порождать») - антигены, вызывающие в организме образование агглютининов (аллоантител). Агглютиногены содержатся в клетках (например, на мембране эритроцитов человека) и обозначаются прописными латинскими буквами А и В. У одних людей на эритроцитах имеется агглютиноген-А, у других - агглютиноген-В, у третьих - агглютиноген-А и агглютиноген-В, у четвертых они вообще отсутствуют (0). По системе АВО, занимающей в исследованиях группы крови основное место, у людей выделяют четыре основные группы крови: 0(I), А(II), В(III), AB(IV).Agglutinogens (lat. Agglutinare - "to glue" and Greek.

- "generate") - antigens that cause the formation of agglutinins (alloantibodies) in the body. Agglutinogens are contained in cells (for example, on the membrane of human erythrocytes) and are designated by capital Latin letters A and B. Some people have agglutinogen-A on erythrocytes, others have agglutinogen-B, others have agglutinogen-A and agglutinogen-B, fourth, they are absent altogether (0). According to the ABO system, which occupies the main place in blood group studies, four main blood groups are distinguished in humans: 0 (I), A (II), B (III), AB (IV).

The isoagglutination reaction, which is the basis for the division of people into blood groups, is considered an immune response, and the agglutination properties of erythrocytes are considered antigens that have corresponding antibodies in the serum. Erythrocytes contain agglutinogens, and serum contains agglutinins. The agglutination reaction occurs when the agglutinogen present in the erythrocytes meets the corresponding agglutinin in the serum. Agglutination occurs when agglutinogen-A meets with α-agglutinin, agglutinogen-B - with β-agglutinin.

Polymerase chain reaction (PCR) is an experimental method of molecular biology based on multiple selective copying of a specific region of a DNA nucleic acid using enzymes in vitro. In this case, copying occurs only of the area that meets the specified conditions, and only if it is present in the sample under study. Unlike DNA amplification in living organisms (replication), relatively short DNA regions are amplified using PCR. In a conventional PCR process, the length of the copied DNA regions is no more than 3000 base pairs (3 kbp). Using a mixture of various polymerases, using additives and under certain conditions, the length of the PCR fragment can reach 20-40 thousand base pairs. The PCR method allows you to very accurately determine the presence of microorganisms that make up the human enterotype.

The way to personify nutrition, taking into account genetically determined factors, consists in the phased selection of food products taking into account genetically determined factors (the immune system of the blood (blood groups + Rh factor), gender (man or woman) and enterotypes (enterotype No. 1 bacteroids - Bacteroides, enterotype No. 2 of Prevotella - Prevotella or enterotype No. 3 of Ruminococcus - Ruminococcus)), according to the following algorithm:

- determine the blood group by the amount of agglutinins (α and β) in plasma, agglutinogens (A and B) in erythrocytes and find the Rh factor;

- determine the compatibility of food components with the components of the blood immune system by the isoagglutination reaction: α and β-agglutinins, A- and B-agglutinogens, as well as Rh ⁺ and Rh ^{- the} Rh factor;

- remove food products from the diet, the components of which cause an agglutination reaction with the components of the blood immune system;

- the prevailing enterotype is determined by the polymerase chain reaction method: enterotype No. 1 bacteroids - Bacteroides, enterotype No. 2 Prevotella - Prevotella or enterotype No. 3 ruminococcus - Ruminococcus;

- I remove hard-to-digest food products from the diet, according to the established enterotype:

for enterotype No. 1 with a universal protein-fat-carbohydrate diet, it is possible not to remove food products,

for enterotype No. 2 with a carbohydrate diet, the amount of foods high in proteins and fats is reduced,

for enterotype No. 3 with a carbohydrate-fat diet, the amount of foods with a high protein content is reduced;

- remove food products from the diet, the components of which cause inhibition of the synthesis of sex hormones:

for women - progestogens and estrogens,

for men - androgens. Table 2 shows the main nutritional strategies recommended for people according to the enterotype (intestinal ecosystem), and Table 3 - according to their blood group.

The Rh factor, or Rh, Rh is one of 36 blood group systems recognized by the International Society of Transfusiology (ISBT). Clinically the most important system after the AB0 system.

The Rh factor system consists of blood groups determined by 59 antigens encoded by over 200 alleles. The antigens with increased immunogenic properties are of the greatest practical importance for medicine: D, C, C, E, E. Frequently used terms "Rh-positive" and "Rh-negative" refer only, respectively, to the presence or absence of the Rho antigen (D) with the highest immunogenicity. In addition to its role in blood transfusion, the Rh blood group, in particular the Rho (D) antigen, is an important cause of hemolytic jaundice in newborns or fetal erythroblastosis; To prevent these diseases, the prevention of Rh-conflict is key. The risk of Rh-conflict during pregnancy occurs in couples with an Rh-negative mother and an Rh-positive father.

Blood groups of the Rh factor system are found in different nationalities and in different regions with different frequencies. About 85% of Caucasians are Rh-positive.

In the intestines of each person, there are about a thousand different types of microorganisms (bacteria). This qualitative and quantitative (ratio) set of microorganisms is as individual as fingerprints. However, out of all the diversity, three main ecosystems are distinguished - the enterotype for the predominant microorganism. A microbial ecosystem or microbial or enterotype weighs on average about 2.5 kg and consists of trillions of microorganisms. It is believed that the more diverse the community of microorganisms, the healthier the person.

Each of the three detected enterotypes is named after the dominant group of microorganisms (Table 2):

1. Bacteroides - enterotype No. 1.

2. Prevotella - enterotype №2.

3. Ruminococcus (Ruminococcus) - enterotype No. 3.

Enterotype No. 1 is characterized by the predominance in the intestinal ecosystem of microorganisms of Bacteroides and good assimilation of proteins, animal fats, vegetable oils and carbohydrates. This group of microorganisms capable of synthesizing vitamins (C (ascorbic acid), B ₂ (riboflavin), _B5 (pantothenic acid), ₇ (biotin)).

Enterotype No. 2 is characterized by the predominance of Prevotella microorganisms in the intestinal ecosystem and good absorption of carbohydrates (especially fiber), as well as vegetable oils. This group of microorganisms is capable of synthesizing vitamins (B ₁ (thiamine) and B ₉ (folic acid)).

Enterotype No. 3 is characterized by the predominance of Rumminococcus microorganisms (Ruminococcus) in the intestinal ecosystem and good absorption of carbohydrates (especially polysaccharides: starch and fiber), as well as vegetable oils.

Enterotypes are the result of a balanced microbial community; therefore, phylogenetic and functional differences between enterotypes show the importance of their synergistic interaction with the host organism. The biological balance between humans and microbial flora, formed as a result of evolution, is a kind of indicator of the state of the macroorganism, reacting to various pathological processes in the body and to any changes in the environment. The intestinal microflora has a huge metabolic potential and is capable of carrying out many biochemical processes, making a certain contribution to human physiology. Malnutrition (excessive consumption of sugars, fats, deficiency of dietary fiber, preservatives, dyes and other xenobiotics; unbalanced diet; irregular diet; fasting, sudden changes in diet and diet), various stresses, industrial environmental pollutants, pesticides, lack of sleep , long trips lead to dysfunction of the intestinal microflora - dysbiosis. It has been proven that as a result of dysbiosis, the following pathological conditions develop: pathology of the gastrointestinal tract (irritable bowel syndrome, ulcerative colitis, Crohn's disease, pseudomembranous colitis); immunopathological diseases (rheumatoid arthritis, systemic lupus erythematosus, atopic dermatitis); metabolic diseases (type I and II diabetes, obesity); neurodegenerative diseases (multiple sclerosis, Parkinson's disease, epilepsy); oncological diseases of various origins; lipid metabolism disorders, vascular atherosclerosis. In particular, the development of obesity is associated with disturbances in the energy balance of the body, i.e. regulation of consumption, consumption and storage of energy. Excessive microbial fermentation of dietary fiber and certain other substrates provides the host with a small amount of additional energy, which can contribute to weight gain over time. In addition, it has been shown that microflora affects genes that regulate energy metabolism in the human body. An increased susceptibility of obese and diabetic people to intestinal infection and systemic inflammation has also been found. Intestinal epithelial cells usually provide a dense barrier that separates intestinal bacteria from the systemic circulation. Chronic hyperglycemia destroys the epithelial barrier and facilitates the movement of intestinal bacterial components into the bloodstream, where they contribute to systemic inflammation. The deleterious effects of chronically high glucose levels are mediated by functional reprogramming of epithelial metabolism and transcription. These cellular changes compromise the assembly of tight junction complexes, which are critical to maintaining an intact barrier. A person is not able to determine his enterotype on his own, and, therefore, to choose an optimal diet for himself, which would best meet the individual needs in the substrates of his intestinal microflora, thereby preventing the development of various pathological processes in the body.

Determination of the enterotype is currently carried out by PCR (polymerase chain reaction). The PCR method is the most accurate of all known. Indirect determination of enterotype can be carried out according to food preferences. The enterotype can be suggested by the softness or hardness of the stool. its texture is influenced, among other things, by the activity of the microbiome. The Prevotella hosts have excellent digestion, but the feces are usually thinner. Eterotypes with a predominance of Ruminococcus and Bacteroides are characterized by harder stools and prolonged digestion, but feces, in which there are more Bacteroides, are looser.

Thus, people who prefer meat, poultry, and seafood that do not deny themselves fat and sweet are referred to enterotype No. 1 with a predominance of bacteroids (Bacteroides). The proponents of a vegetarian diet develop enterotype # 2 with a predominance of Prevotella. Those who love cereals, buns, pasta and sweets are ranked as enterotype # 3 with a predominance of Ruminococcus.

Table 4 presents a matrix of 48 possible options for personalized nutrition, taking into account blood groups, rhesus factor, entertypes and gender.

The following table 5 shows examples of specific implementation of the invention.

The decline in the production of sex hormones with age is a determining factor contributing to the deterioration of health in both men and women. To a certain extent, eating can help slow this process down.

Nutrition that increases the level of the male sex hormone - testosterone. Key nutrients

necessary to increase the level of testosterone in the body (i.e. for the nutrition of men) are: amino acids (protein), zinc, B vitamins, omega-3 fatty acids. These nutrients are found in both plant and animal foods, but there is no reason to believe that you need to eat steak, eggs, chicken, fish, or drink milk to increase testosterone levels. In fact, many animal products can actually increase estrogen levels in the body, which lowers testosterone levels and can lead to some negative side effects due to estrogen coming from animals that have hormones that our bodies shouldn't have. use.

Some of the most important testosterone-boosting foods include:

Pumpkin seeds. Pumpkin seeds are rich in zinc, an essential mineral needed for optimal testosterone levels. Zinc keeps the genitals healthy and promotes healthy metabolism, which aids in the conversion of certain hormones. They are also great sources of tryptophan, an amino acid that helps the body produce more serotonin, which helps balance your hormones even more. These alkaline green seeds are also one of the most overlooked sources of plant-based protein, iron, and are excellent sources of healthy omega-3 fats.

Coconut and coconut milk. Coconut is a great food for boosting muscle growth, maintaining lean body mass, and balancing your body's hormones, including testosterone. It is a great source of healthy saturated fat, which most people find it necessary to avoid, but when eaten from plant sources, it is actually beneficial in moderation. Saturated fats are essential for testosterone production, and they support the body's ability to produce cholesterol without the need for additional dietary cholesterol from animal products. A few tablespoons of raw coconut oil, crumbs, coconut milk, or fresh coconut meat are all you need to support your body with this healthy source of fat. It's still a good idea to limit all sources of saturated fat to 10 percent of your daily diet and not rely on them alone.

Maca. Maca is a great food to boost and normalize or improve hormones. It can boost libido and improve mood in both men and women, and is fantastic for reducing stress levels, which can affect healthy testosterone levels. Maca is also great for boosting your energy to help you exercise, which boosts testosterone in response. When you exercise, especially when you lift weights, you naturally increase your testosterone levels, making maca a great superfood to use in every way. Exercise and maca also support your body's production of growth hormones, which support your metabolism and keep your body young.

Avocado. Plus, it's a libido-boosting food, the fruit's healthy fats and high levels of vitamin B 6 reduce cortisol levels and improve testosterone production. They also support metabolism and overall mood function. Avocado fats also lower high levels of harmful cholesterol (LDL) levels that interfere with testosterone production. Animal fats raise high LDL levels, while vegetable fats lower LDL cholesterol and improve good cholesterol (HDL). Check out more herbal foods with good cholesterol levels that can also support your hormones here.

Chia seeds. Chia seeds directly increase testosterone levels in the body thanks to their amazing essential fatty acid (EFA) profile. They are an excellent source of omega-3 fats, along with other anti-inflammatory fats. Chia seeds are also a great source of potassium, zinc, iron, magnesium, which support your metabolism, blood pressure, blood sugar, and mood. These nutrients are also required for optimal energy and hormone production in the body. Hemp seeds are also amazing for your hormone levels, and they contain more protein, iron, and magnesium than chia seeds.

Fatty fish. The most useful are the following oily sea fish: herring, mackerel, salmon, sardine.

Food that helps to reduce the level of the male sex hormone - testosterone. There are a large number of foods that lower testosterone levels (i.e., have an antiandrogenic effect). Foods lower testosterone levels by increasing the activity of the enzyme aromatase, which converts testosterone to estrogen. The overall effect of increased aromatase activity is to lower testosterone levels and increase estrogen levels. This is especially important for men, whose aromatase enzyme activity seems to be more sensitive to food triggers: cheese, yogurt, bread, pasta, crackers, rice, cereals, chocolate, alcohol, coffee, mint.

Foods containing phytoestrogens in large quantities, i.e. increasing the level of estrogen - female sex hormones. There are a large number of foods containing phytoextrogens in large quantities that can only be useful for women:

Flax-seed. Flaxseeds are small, golden or brown seeds that have been gaining strength lately for their potential health benefits. They are incredibly rich in lignans, a group of chemical compounds that act like phytoestrogens. In fact, flaxseed contains 800 times more lignans than other plant foods. Research has shown that the phytoestrogens found in flax seeds may play an important role in lowering the risk of breast cancer, especially in postmenopausal women. Flax seeds are a rich source of lignans, chemical compounds that function as phytoestrogens. Eating flax seeds has been linked to a reduced risk of breast cancer.

Soya beans. Soybeans are processed into many plant-based foods such as tofu and tempeh. They can also be enjoyed whole, like edamame. Edamame beans are green, unripe soybeans that are often sold in frozen and unpeeled shells in inedible pods. Both soy and edamame have been linked to many health benefits and are rich in protein and many vitamins and minerals. They are also rich in phytoestrogens known as isoflavones. Soy isoflavones can induce estrogen-like activity in the body by mimicking the effects of natural estrogen. They can increase or decrease the level of estrogen in the blood. One study found that women who took soy protein supplements for 12 weeks had a moderate decrease in blood estrogen levels compared to a control group. Researchers have suggested that these effects may help protect against certain types of breast cancer. The effect of soy isoflavones on human estrogen levels is complex. Ultimately, more research is needed before conclusions can be drawn. Soybeans and edamame are rich in isoflavones, a type of phytoestrogen. Soy isoflavones can affect blood estrogen levels in your body, although more research is needed.

Dried fruits. Dried fruit is rich in nutrients, delicious and easy to eat as a snack. They are also a powerful source of various phytoestrogens. Dates, prunes and dried apricots are some of the richest phytoestrogen sources of dried foods. What's more, dried fruit is loaded with fiber and other essential nutrients, making it a healthy snack. Dried fruits are a powerful source of phytoestrogens. Dried apricots, dates and prunes are some of the dried fruits with the highest phytoestrogen content.

Sesame seeds. Sesame Seeds are small, fibrous seeds commonly added to Asian dishes to add a delicate crunch and nutty flavor. They are also quite rich in phytoestrogens, among other important nutrients. Interestingly, one study found that consumption of sesame seed powder could affect estrogen levels in postmenopausal women. The women in this study consumed 50 grams of sesame seed powder daily for 5 weeks. This not only increased estrogen activity, but also improved blood cholesterol levels. Sesame seeds are a powerful source of phytoestrogens. Regular consumption of sesame seeds has been shown to increase estrogen activity in postmenopausal women.

Garlic. Garlic is a popular ingredient that gives food a pungent flavor and aroma. Not only is it touted for its culinary qualities, it is also known for its medicinal properties. Although research into the effects of garlic in humans is limited, numerous animal studies have shown that it can affect blood estrogen levels. In addition, a month-long study in postmenopausal women found that garlic oil supplements may have protective effects against estrogen deficiency-related bone loss, although more research is needed. Along with its distinctive taste and health benefits, garlic is rich in phytoestrogens and may help reduce bone loss associated with estrogen deficiency. However, more human studies are needed.

Peaches. Peaches are a sweet fruit with yellowish white flesh and. They are not only rich in vitamins and minerals, but also rich in phytoestrogens known as lignans. Interestingly, research analyzes show that lignan-rich diets can reduce the risk of breast cancer by 15% in postmenopausal women. Perhaps this is due to the effect of lignans on estrogen production and blood levels, as well as their expression in the body. Peaches are sweet, tasty, and packed with a variety of nutrients. They are rich in lignans, a type of phytoestrogen.

Berries. Berries have long been touted for their many impressive health benefits. They are loaded with vitamins, minerals, fiber, and beneficial plant compounds including phytoestrogens. Strawberries, cranberries, and raspberries are particularly rich sources.

Wheat bran. Wheat bran is another concentrated source of phytoestrogens, especially lignans. Some dated human studies show that high-fiber wheat bran lowers serum estrogen levels in women. However, these results were likely related to the high fiber content of the wheat bran and not necessarily the lignan content. Ultimately, more research is needed to fully understand the effects of wheat bran on circulating estrogen levels in humans. Wheat bran is rich in phytoestrogens and fiber, which can lower estrogen levels. However, more research is needed.

Tofu. Tofu is made from coagulated soy milk pressed into solid white blocks. It is a popular source of plant-based protein, especially in vegan and vegetarian diets. It is also a concentrated source of phytoestrogens, mainly isoflavones. Tofu has the highest isoflavone content of any soy product, including soy blends and soy drinks. Tofu is made from soy milk condensed into solid white blocks. It is a rich source of isoflavones, a type of phytoestrogen.

Cruciferous vegetables. Cruciferous vegetables are a large group of plants with a variety of flavors, textures, and nutrients. Cauliflower, broccoli, Brussels sprouts, and cabbage are cruciferous vegetables that are rich in phytoestrogens. Cauliflower and broccoli are rich in secoisolariciresinol, a type of phytoestrogen lignan. In addition, Brussels sprouts and kale are rich in coumestrol, another type of phytonutrient that has been shown to exhibit estrogenic activity. Cruciferous vegetables are rich in phytoestrogens, including lignans and coumestrol.

Tempe. Tempeh is a fermented soy product and a popular vegetarian meat substitute. It is made from soybeans that have been fermented and compressed into a hard, dense cake. Tempeh is not only an excellent source of protein, prebiotics, vitamins and minerals, but also a rich source of phytoestrogens, especially isoflavones.

Nuts. Nuts are perhaps the healthiest snack food. You can have them raw or you can fry them. Consume nuts like pistachios, peanuts, and walnuts as they are excellent sources of estrogen. A bowl full of these nuts can offer just the right amount of phytoestrogens and isoflavones your body needs.

Red wine. Red wine contains high amounts of the phytoestrogen resveratrol, which can improve the functioning of female hormones. Limiting consumption of this drink may reduce the risk of heart disease.

) и энтеротипов (энтеротип №1: бактероиды (Bacteroides), энтеротип №2: превотелла (Prevotella) и энтеротип №3: руминококки (Ruminococcus)), позволяющий осуществлять точную и максимально персональную регуляцию пищевого поведения человека.Thus, we have proposed a highly effective method for personifying nutrition, taking into account blood groups (0 (I), 0A (II), 0B (III), AB (IV)), blood Rh factor (Rh ⁺ and Rh ^- ), gender (

) and enterotypes (enterotype No. 1: Bacteroides, enterotype No. 2: Prevotella and enterotype No. 3: Ruminococcus), which allows for precise and maximally personal regulation of human eating behavior.

Sources of information taken into account when completing the application:

1. Information Internet: Croncolith. Information and educational project. Treatment tables (diets) No. 1-15 according to Pevzner: food tables and diet: https://kronkolit.pro/lechebnyye-stoly-diyety-№-1-15-po-pevzneru/. - Date of entry: 12/27/2019

2. Information Internet: Material from Wikipedia - the free encyclopedia: Nutrition: https://ru.wikipedia.org/wiki/ Nutrition. - Date of entry: 12/30/2019

Claims (12)

A method of personifying nutrition, taking into account genetically determined factors, including the nutrition process - the selection of food products and their absorption to maintain life and health, the normal course of physiological processes of life, to replenish the energy supply and implement the processes of growth and development, characterized in that the selection of food products is based on genetically determined factors: the immune system of the blood - blood groups and Rh factor, enterotypes, as well as gender, while food products are selected in stages, according to the following algorithm: - determine the blood group by the amount of agglutinins α and β in plasma, agglutinogens A and B in erythrocytes and find the Rh factor; - the compatibility of food components with the components of the blood immune system is determined by the isoagglutination reaction: α- and β-agglutinins, A- and B-agglutinogens, as well as Rh ⁺ and Rh ^{- the} Rh factor; - remove food products from the diet, the components of which cause an agglutination reaction with the components of the blood immune system; - the prevailing enterotype is determined by the polymerase chain reaction method: enterotype No. 1 bacteroids - Bacteroides, enterotype No. 2 Prevotella - Prevotella or enterotype No. 3 ruminococcus - Ruminococcus; - remove from the diet food products that are difficult to digest for the established enterotype: for enterotype No. 1 with a universal protein-fat-carbohydrate diet, it is possible not to remove food products, for enterotype No. 2 with a carbohydrate diet, they reduce the amount of foods high in proteins and fats, for enterotype No. 3 with a carbohydrate-fat diet, the amount of foods with a high protein content is reduced; - remove food products from the diet, the components of which cause inhibition of the synthesis of sex hormones: for women - progestogens and estrogens, for men - androgens.