RU2745759C1 - Method for treatment of acute pulmonary insufficiency and device for its implementation savelieva b.s. - Google Patents

Abstract

FIELD: medical equipment.

SUBSTANCE: group of inventions relates to medical equipment and namely to a method for treating acute pulmonary insufficiency and a device for implementing the method. According to the method, the most intact lung is preliminarily isolated by artificial ventilation with an air-oxygen mixture, and an oxygenated solution of perfluorane is introduced into the second lung through an endotracheal tube equipped with obturating cuffs, followed by replacement of perfluorane with an air mixture. After removal of perfluorane from the lung, it is artificially ventilated with an air-oxygen mixture. In the method, wave biomechanotherapy of the lower leg and chest muscles is additionally carried out in the biomechanical resonance mode, in which the modes of exposure to the spine and respiratory muscles of the chest are synchronized with the breathing phases. At the same time, a mixture of oxygenated perfluorane solution with drugs is supplied to the second lung by impulses in the form of a solitary wave with the frequency of the biomechanical spectrum through the endotracheal tube using a unit for supplying a liquid respiratory mixture. This mixture is fed while inhaling under a pressure of 8÷30 mm Hg. and during exhalation under pressure minus 8÷30 mm Hg. until the partial pressure of oxygen in the blood is at least 80 mm Hg. Removal of perfluorane from the lungs after the cessation of the supply of liquid breathing mixture is carried out with the patient in the prone position, on the right and left sides, causing a cough reflex and synchronously with it, carrying out biomechanical stimulation of the respiratory muscles of the chest, and after the removal of anesthesia, wave biomechanotherapy of the muscles of the chest is performed. The device for implementing the method of treating acute pulmonary insufficiency includes a device for artificial ventilation of the lungs, a unit for supplying a liquid respiratory mixture, an endotracheal tube equipped with obturating cuffs. The device contains units for wave biomechanotherapy of the muscles of the lower leg and chest, a unit for biomechanical stimulation of the respiratory muscles of the chest, the obturating cuffs are made vibrating. The obturating cuffs of the endotracheal tube and all nodes operate at biomechanical resonance frequencies.

EFFECT: said method is aimed at reducing the likelihood of an inflammatory response of the respiratory tract to tracheal intubation, reducing the risk of ischemic damage to the tracheal mucosa, ensuring sufficient blood oxygenation in severe forms of hypoxemia, increasing the body's defense against infection, using a mixture of perfluorane with low doses of drugs for treatment of lung diseases, reducing postoperative lungs complications.

2 cl, 3 dwg

Description

The group of inventions relates to medicine, more precisely to surgery and resuscitation, and can be used in the treatment of parenchymal respiratory failure with low blood oxygenation, as well as in the treatment of acute diseases of the broncho-pulmonary system.

In acute pulmonary failure, the external respiration system does not provide a normal blood gas composition and its maintenance at a normal level is achieved due to excessive stress of this system, and the external respiration apparatus cannot provide the body with a sufficient amount of oxygen and eliminate carbon dioxide with normal energy consumption.

Pulmonary insufficiency in various pathological conditions is eliminated:

- by intrapulmonary injection and removal of the gas mixture (1), which can provide a positive therapeutic effect with a functioning pulmonary parenchyma and with preserved transmembrane gas exchange. However, with a pronounced degree of parenchymal respiratory failure, this method is ineffective;

- by connecting physicochemical oxygenators of blood into the bloodstream between the vein and the artery (2), which ensure complete oxygenation of the blood in any condition of the pulmonary parenchyma. However, this method is invasive and, due to its high trauma, can be used only for a fairly short time. At the same time, it does not have a therapeutic effect on the lung tissue.

A known method for the treatment of acute respiratory distress syndrome, including the introduction of perfluorocarbon into the patient's respiratory tract under artificial ventilation with positive pressure at the end of expiration, in which the level of positive pressure at the end of expiration is set higher than the pre-selected optimum by 4-8 cm of water column. , after 10-15 minutes of maintaining which perfluorocarbon is injected in the form of an aerosol using a nebulizer for 10-15 minutes. (Patent No. 2265434).

The disadvantage of this method is that when perfluorocarbon is introduced in the form of an aerosol, a low degree of oxygenation is achieved, and when administered with a drug, it is difficult to deliver it to the alveoli through the bronchi with a small diameter, the aerosol will settle on the roots of the bronchi.

A known method of improving the oxygenating function of the lungs in patients with respiratory failure, who are on artificial lung ventilation, including the introduction of a drug, characterized in that the latter is used serotonin adipate, a solution of 10-500 mg of which is administered intravenously at a rate of 10-30 mg / h ... The intravenous administration procedure is continued for 10-14 days (Patent No. 2245139).

The main disadvantage of this method is a delayed action - the first clinical signs of an improvement in the oxygenating function of the lungs appear after 30-40 minutes due to the intravenous administration of the medicinal solution.

The intravenous procedure leads to exotoxicosis, artificial ventilation does not provide for liquid respiration - it is not effective in acute respiratory failure, namely in the treatment of parenchymal respiratory failure with low blood oxygenation.

A known method for the treatment of respiratory distress syndrome in adults, including artificial ventilation of the lungs and endobronchial administration of natural pulmonary surfactant, surfactant-BL is used as a surfactant, which is administered from the first hours of the development of respiratory failure in an amount of 700-1000 mg bolus or micro-jet, and then after 30 -60 minutes in the form of an aerosol constantly, for 15-60 hours in an amount of 30-60 mg / h, after which the patient is extruded (Patent No. 2149016).

It is assumed that the exogenous surfactant stabilizes the alveolar wall, prevents the collapse of the alveoli, thereby increasing the volume of the functioning lung parenchyma, while the pressure in the airways decreases.

This technique leads to depressurization of the circuit, collapse of unstable alveoli, an increase in pressure in the airways; violation of ventilation-perfusion relations; a long waiting time for a positive clinical effect, which develops only after a few hours; the need to extend the microjet injection of the drug; late initiation of surfactant therapy (over 24-72 hours), which gives a much smaller clinical effect, up to complete ineffectiveness.

In addition, in patients with more pronounced parenchymal damage to the lungs, the distribution of the drug is extremely uneven due to atelectasis of large areas of the pulmonary parenchyma.

Known devices for the treatment of pulmonary insufficiency include a ventilator and a gas supply unit. Respiratory mixtures are administered by aerosol or piston method (Patent Nos. 2265434, 2149016).

The disadvantage of the known devices lies in the difficulty of delivering the required amount of drugs to the alveoli through the bronchi with a small diameter, the aerosol will settle on the roots of the bronchi.

All methods increase the load on the heart, muscular system, respiratory system, which means that they increase oxygen consumption by the whole body during anesthesia, thereby reducing blood oxygenation.

The closest analogue is a method of treating pulmonary insufficiency, which consists in the fact that the most intact lung is preliminarily isolated by artificial ventilation with an air-oxygen mixture, and an oxygenated solution of perfluorane is injected through an endotracheal tube equipped with obturating cuffs into the second lung mixed with a solution 0.9% sodium chloride solution at a ratio of 1: 3-1: 10, and this mixture is fed through a catheter introduced into the lumen of the endotracheal tube under a pressure of 5-8 mm Hg. until the partial pressure of oxygen in the blood is at least 70 mm Hg, and after removal of perfluorane from the lung, it is artificially ventilated with an air-oxygen mixture for at least 30 minutes.

The device with which this method is carried out includes an artificial lung ventilation device, a piston unit for supplying a liquid respiratory mixture and an endotracheal tube equipped with obturating cuffs (Patent RU 2133606, publ. 1999).

The disadvantage of the known method for the treatment of pulmonary insufficiency and the device for its implementation is the prolonged immobility of the patient, especially during surgery and anesthesia, which inevitably leads to ventilation-perfusion disorders, since as a result of the action of the gravitational factor, perfusion is displaced into the lower parts of the lungs, and ventilation - in the overlying (3). Therefore, the introduction of a mixture of perfluorane through a catheter without a significant volume and under a pressure of 5-8 mm Hg. (without prolonged lavage of the bronchi of the lungs) does not eliminate ventilation-perfusion disorders. At the same time, inflation of the cuff and prolonged pressure of the cuffs on the walls of the bronchi and trachea creates the likelihood of an inflammatory reaction of the airways to tracheal intubation and increases the risk of ischemic damage to the tracheal mucosa, which can lead to the development of post-intubation laryngeal stenosis. The pressure of the cuffs reduces blood flow in the bronchial vessels that feed the lung, and the pulmonary vessels, intended for gas exchange of the whole body, in most cases of acute respiratory failure and anesthesia, the presence of a respiratory dead space cannot provide oxygen to the entire body. This factor is further aggravated by the immobility of the muscle-venous pump of the lower leg during anesthesia, which reduces its function of maintaining peripheral blood flow, and therefore increases the load on the heart, increases the oxygen consumption of the cardiovascular system. The load on the heart and lungs increases, which are a reservoir of blood included in the circulatory system between the right and left halves of the heart pump. Due to respiratory failure, the blood flow rate decreases and, as a result, an increase in viscosity and a decrease in the antibacterial properties of blood, which reduces the body's defense against infection and makes it difficult to use a mixture of pertfluorane with low doses of drugs for the treatment of lung diseases.

Other disadvantages of the known method include the lack of stimulation of discharge and artificial removal of perfluorane solution and sputum from the lungs, which creates the risk of postoperative complications from the lungs, especially due to insufficient partial pressure of oxygen in arterial blood equal to or less than 70 mm Hg. before removing perfluorane and phlegm from the lungs.

The objectives of the proposed group of inventions are:

- reducing the likelihood of an inflammatory response of the airways to tracheal intubation;

- reducing the risk of ischemic damage to the tracheal mucosa;

- ensuring sufficient oxygenation of the blood in severe forms of hypoxemia;

- increasing the body's defense against infection;

- the use of a mixture of perfluorane with low doses of drugs for the treatment of lung diseases;

- reduction of postoperative lung complications.

The problem is solved by the fact that in the method of treating acute pulmonary insufficiency Savelyev B.S., which consists in the fact that the most intact lung is preliminarily isolated by artificial ventilation with an air-oxygen mixture, and oxygenated perfluorane solution is introduced into the second lung through the endotracheal tube, equipped with occlusive cuffs, followed by replacement of perfluorane with an air mixture, and after removal of perfluorane from the lung, it is artificially ventilated with an air-oxygen mixture, unlike the closest analogue, wave biomechanotherapy of the leg and chest muscles is additionally carried out in the biomechanical resonance mode, in which the exposure modes the spine and respiratory muscles of the chest are synchronized with the phases of breathing, while through the endotracheal tube with the use of a liquid breathing mixture supply unit, the second lung is supplied with pulses in the form of a solitary wave with the frequency of the biomechanical spectrum a mixture of hydroxy a genated solution of perfluorane with drugs, and this mixture is fed with inhalation under a pressure of 8 ÷ 30 mm Hg. and during exhalation under pressure minus 8 ÷ 30 mm Hg. until the partial pressure of oxygen in the blood is at least 80 mm Hg, while the removal of perfluorane from the lung after the cessation of the supply of liquid breathing mixture is carried out with the patient in the prone position, on the right and left side, causing a cough reflex and synchronously with it, biomechanical stimulation of the respiratory muscles of the chest, and after the removal of anesthesia, wave biomechanotherapy of the muscles of the chest is performed.

A device for implementing the method of treating acute pulmonary insufficiency Savelyev B.S., including a ventilator, a liquid breathing mixture supply unit, an endotracheal tube equipped with obturating cuffs, in contrast to the closest analogue, additionally contains nodes for wave biomechanotherapy of the muscles of the leg and chest, a node biomechanical stimulation of the respiratory muscles of the chest, in addition, the obturating cuffs are made vibrating, and the obturating cuffs of the endotracheal tube and all units operate at frequencies of biomechanical resonance.

The essence of the group of inventions lies in the use in the treatment of acute pulmonary insufficiency of an endotracheal double-lumen tube equipped with obturating vibrating cuffs, which allows, by deflation and filling of the cuffs according to the controller's program during intubation, to reduce friction about the trachea due to the fact that sliding friction occurs due to oscillation of the cuffs , and during the operation to avoid prolonged static pressure of the cuffs on the walls of the bronchi and trachea. This eliminates the inflammatory response of the airways to tracheal intubation and reduces the risk of ischemic injury to the tracheal mucosa. The elimination of cuff pressure promotes blood flow in the bronchial vessels that feed the lung. Inserting the tube with its distal end into the bronchus of the lung for oxygenation with a perfluorane solution reduces the hydrostatic resistance during liquid breathing, in contrast to the introduction of perfluorane through the holes in the bend of the tube. The supply of the air-oxygen mixture through the holes in the tube causes insignificant aerostatic resistance.

The method uses the techniques of wave biomechanotherapy (4, 5) and biomechanical stimulation (6, 7) in the form of exposure to solitary mechanical waves generated as a result of the movement of the elastic medium, in the proposed group of inventions it allows to use a muscular-venous pump to return blood to the heart. According to the controller's program, the cuff of the wave biomechanotherapy unit affects the muscles of the lower leg, which in the biomechanical resonance mode act as a peripheral heart and increase hemodynamics in the cardiovascular system, which means that they promote rapid oxygenation of the whole organism. Wave biomechanotherapy of the chest muscles reduces significant hydraulic pressure in the lungs during liquid breathing. Moreover, the modes of action on the spine and respiratory muscles of the chest are synchronized with the phases of breathing, that is, they are selected in the mode of biomechanical resonance (8), in which perftoran reaches the alveoli, but does not damage the tissues of the bronchi and lungs. This ensures bronchial lavage and stimulates the work of the respiratory muscles of the chest in the biomechanical resonance mode, which significantly reduces their oxygen consumption, which means that oxygenation of the whole organism increases.

The presence of a liquid artificial respiration system (9) of the lungs with a mixture of an oxygenated solution of perfluorane with drugs due to the delivery of perfluorane through the endotracheal tube by mechanical impulses with the frequency of the biomechanical spectrum makes it possible to reduce the hydraulic pressure in the bronchi. This is achieved due to the fact that the impulse supply of the liquid respiratory mixture generates a solitary wave, and not a harmonic wave, which occurs when the piston injection of perfluorane. A solitary wave is like a particle and spreads through the bronchi without significant hydraulic resistance. In this case, the maximum pressure in a solitary wave at the initial moment during inhalation, namely, in the node for supplying a liquid breathing mixture, is less than 8 mm Hg. causes hydraulic resistance, which reduces the wave velocity in the bronchi, and the maximum pressure is more than 30 mm Hg. can cause damage to the connective tissue of the bronchi. Similarly, when you exhale, a negative pressure of -8 mm Hg. does not allow to completely pump out perftoran from the lungs, and less than -30 mm Hg. can disrupt connective tissue and the functioning of the alveoli. The pressure and all parameters of liquid breathing are regulated by the frequency of oscillation of the cuffs in the unit for supplying the liquid breathing mixture. For example, inhalation lasts 2 seconds. During this time, piston pressure, as is the case with artificial ventilation with an air-oxygen mixture, it is extremely difficult to pump liquid into the bronchi due to the branched system of bronchial vessels of different diameters and, as a result, high hydraulic resistance. The presence of mechanical impulses with the frequency of the biomechanical spectrum allows the perfluorane solution to be delivered impulsively in the form of a solitary wave, which behaves like a particle, through the endobronchial tube. In this case, liquid respiration occurs and there is an effective assimilation of drugs by the lung tissue and, most importantly, by the alveoli, bypassing the delivery of drugs through the systemic circulation. At the same time, artificial ventilation with an air-oxygen mixture of a working lung sets the rhythm of liquid respiration and synchronizes the work of the whole organism for accelerated blood oxygenation in severe forms of hypoxemia until the partial pressure of oxygen in the blood is at least 80 mm Hg, sufficient for the supply of oxygen in the blood for in order to start, after the body has absorbed drugs, to remove perfluorane and sputum from the lungs using biomechanical stimulation of the respiratory muscles of the chest.

The presence in the proposed group of inventions of biomechanical stimulation of the respiratory muscles of the chest can increase the force of contraction and hemodynamics of the respiratory muscles and significantly reduce their energy consumption. The combination of low oxygen consumption in the respiratory muscles of the chest, contracting with a large amplitude, with the cough reflex when the patient is in the prone position, on the right and left sides, causes the effective removal of a mixture of perfluorane and sputum. Artificial ventilation of both lungs with an air-oxygen mixture after removing a mixture of perfluorane and sputum and removing anesthesia, carrying out biomechanical stimulation of the respiratory muscles of the chest eliminates the risk of postoperative complications from the broncho-pulmonary system.

The proposed method for the treatment of acute pulmonary insufficiency and a device for its implementation Saveliev B.S. are illustrated by drawings, where

in fig. 1 shows a diagram of the location of the endotracheal tube in the patient's body;

in fig. 2. shows a device for implementing the method of treating acute pulmonary insufficiency Saveliev B.S .;

in fig. 3 shows the operation of a cylinder with pneumatic cuffs for supplying a liquid breathing mixture.

A device for implementing the method of treating acute pulmonary insufficiency Savelyeva B.S. contains an endotracheal double-lumen tube 1 with obturating vibrating cuffs 2 (Fig. 1) with air ducts 3 and 4 (Fig. 1) for supplying air with variable programmable pressure in them, air duct 5 for artificial ventilation of the lungs with an air-oxygen mixture, a fitting 7 for connection unit for supplying liquid breathing mixture, compressor 8, block of electro-pneumatic valves 9, control controller 10, unit for supplying liquid breathing mixture, consisting of a cylinder with pneumatic cuffs 11 for inhaling perfluorane and a cylinder with pneumatic cuffs 12 for exhaling perfluorane, compressor 13, block of electro-pneumatic valves 14, controller 15 , artificial lung ventilation device 16, node for wave biomechanotherapy of leg muscles 17, node for wave biomechanotherapy of chest muscles 18, node for biomechanical stimulation of respiratory muscles of the chest 19, compressor 20, electro-pneumatic valves 21 and 22, controller 23, check valve 24, liquid receiver 25, device 26 for purification and oxygenation of perfluorane, pump 27 , non-return valve 28, non-return valve 29.

A method for the treatment of acute pulmonary insufficiency Saveliev B.A. using the proposed device is carried out as follows.

When a patient develops a critical condition, for example, with a severe form of hypoxemia, the patient is intubated with an endotracheal tube 1 with obturating vibrating cuffs 2. The endotracheal tube 1 is inserted with its distal end into the bronchus of the lung for oxygenation with a perfluorane solution. The patient is placed on the cuff of the wave biomechanotherapy unit of the chest muscles 18 to stimulate the respiratory muscles of the chest from the back. Further, the cuff of the wave biomechanotherapy unit of the leg muscles 17 is fixed on the legs to eliminate venous stasis on the lower extremities of the patient's body. Wave biomechanotherapy of the leg and chest muscles is started using the Biom-Wave complex, reg. certificate No. FSR 2010/07031 dated December 29, 2012. An air-oxygen mixture is supplied to the most efficient lung with the help of an artificial ventilation device 16 through the air duct 5 of the endotracheal tube 1. The artificial lung ventilation device 16 sets a breathing rhythm, through which a unit for supplying a liquid breathing mixture is connected, consisting of a cylinder with pneumatic cuffs 11 for inhaling perfluorane and cylinder with pneumatic cuffs 12 for exhalation of perfluorane. Before inhalation with the help of the compressor 8, the block of electro-pneumatic valves 9 and the control controller 10, all pneumo-cuffs of the cylinder 11 are deflated to create an inhalation of perfluorane. Cylinder 11 is filled with a mixture of perfluorane from a liquid receiver 25 through a check valve 24. At this point in time, the pneumo-cuff of cylinder 12, which serves for the exhalation of perfluorane, is filled with air due to the compressor 13 and the operation of the block of electro-pneumatic valves 14 under the control of controller 15. Perftoran is displaced from cylinder 12 through check valve 29 for purification and oxygenation of perfluorane into device 26. Check valve 28 is closed and does not allow perfluorane from cylinder 12 to enter the lungs through endotracheal tube 1. At the moment of the beginning of inhalation, the electric pneumatic valves of the block 9 are switched on by command, and the pneumatic cuffs inside the cylinder 11 are filled with air alternately (Fig. 3), thereby causing the impulsive displacement of the perfluorane from the cylinder 11 into the lung.

The frequency with which the pneumatic cuff is filled with air belongs to the biomechanical spectrum, as a result of which a pulsed supply of a mixture of oxygenated perfluorane solution with drugs to the lung occurs. In this case, it becomes possible to supply perfluorane under a pressure of 5 to 30 mm Hg. impulsively in the form of a solitary wave, the properties of which allow perftoran to spread through the bronchi without hydraulic resistance. After filling the bronchi with pertfluorane and ending the inhalation, the exhalation phase is carried out by alternately deflating the pneumo-cuffs of the cylinder 12 by turning off the electro-pneumatic valves of the unit 14 under the control of the controller 15 and alternately releasing the air from the pneumatic cuffs. At the same time, the pressure in the cylinder 12 drops, a vacuum is created and the check valve 29 closes, but the check valve 28 opens, through which, due to the vacuum, the perfluorane flows from the lungs into the cylinder 12. To repeat the inhalation, it is necessary through the pump 27 from the device 26 for purification and oxygenation of perfluorane, fill the liquid receiver 25 with perfluorane. Periodically, during liquid breathing, the programmed controller 23 controls, using the compressor 20 and the electro-pneumatic valves 21, 22, the filling and outflow of air in the occluding vibrating cuffs of the endotracheal double-lumen tube 1 through the air ducts 3 and 4 (Fig. 1). Thus, a variable programmable pressure is created in them and eliminates ischemic damage to the tracheal mucosa and the formation of blood clots in the bronchial vessels due to prolonged pressure of the endotracheal tube cuffs 1.

Artificial ventilation with an air-oxygen mixture of a working lung and liquid breathing create conditions for accelerated blood oxygenation in severe forms of hypoxemia to achieve a partial pressure of oxygen in the blood of at least 80 mm Hg, which is necessary for the onset of adequate spontaneous breathing and a sufficient margin of time to start after assimilation of drugs by the body to remove perfluorane and sputum from the lungs using biomechanical stimulation of the respiratory muscles. To do this, remove the air in the cuffs 2 of the endotracheal tube 1, remove it from the patient's trachea, stop the work and remove the nodes of wave biomechanotherapy of the muscles of the lower leg 17 and chest 18. Further, when the patient is on his stomach, on the right and left sides, they cause a cough reflex and synchronously with him, acting from the back with the help of a unit for biomechanical stimulation of the respiratory muscles of the chest 19 (complex "Biom-Wave", per. certificate No. FSR 2010/07031 dated 29.12.2012) remove perfluorane and sputum from the lungs. After that, artificial ventilation of both lungs is carried out with an air-oxygen mixture, and after removal of anesthesia, wave biomechanotherapy of the chest muscles is carried out using the wave biomechanotherapy unit of the chest muscles 18 (Biom-Wave complex, registration certificate No. FSR 2010/07031 dated 29.12. 2012).

A method for the treatment of acute pulmonary insufficiency Saveliev B.A. with the help of the proposed device in comparison with the known has a number of significant advantages. Most lung diseases are associated with parenchymal respiratory failure and inflammation of the lung tissue, usually of infectious origin, with a predominant lesion of the alveoli and interstitial lung tissue. However, traditional antibacterial and antiviral therapies involve administering medication through an intravenous catheter. As drugs move through the vascular system, they penetrate into various organs and are absorbed by them, causing exotoxicosis. The dose of drugs that goes directly to the lungs is significantly less than the amount administered. The proposed method is devoid of this drawback. A mixture of oxygenated perfluorane solution with drugs is delivered directly to the affected alveoli. Therefore, this method of treatment is effective in the treatment of pneumonia and in the treatment of acute diseases of the bronchopulmonary system. The circulation of perfluorane with drugs ensures a continuous supply of oxygen to the functional elements of the lung and a sufficient supply of drugs to the alveoli and lung tissues.

The use of wave biomechanotherapy (4, 5), biomechanical stimulation (6, 7) and treatment with oxygenated perfluorane solution (9) have been tested and have practical applicability. The combined use of all elements will significantly increase the effectiveness of treatment and reduce the rehabilitation period after treatment of acute pulmonary failure.

The proposed method for the treatment of acute pulmonary insufficiency and a device for its implementation Savelyev B.S. eliminates pulmonary insufficiency in critical conditions of the patient (severe lesions of the lung parenchyma, respiratory distress syndrome), accompanied by a severe form of hypoxemia, makes it possible to effectively treat pneumonia and acute diseases of the broncho-pulmonary system.

The proposed method simultaneously has a therapeutic effect on the lung tissue, relieving its edema and restoring the ability of the alveolar membranes for gas exchange, and can be used for a sufficiently long time necessary to saturate the blood with oxygen with normal partial pressure and drugs, which cannot be provided by other known methods. At the same time, the method significantly reduces the period of rehabilitation after treatment.

According to experts, for example, the treatment of pneumonia using this method is possible in 2-4 days. At the same time, much less drugs will be required than with traditional treatment, and at the same time it becomes possible to significantly reduce toxicosis from the use of antibacterial and antiviral drugs.

Information sources

1. Burlakov R.I. and other Artificial ventilation of the lungs. Moscow: Medicine, 1986.

2. Osipov V.P. Fundamentals of artificial blood circulation. M .: Medicine, 1976, 320 p.

3. Prasmytskiy O.T. Intensive therapy of diseases accompanied by acute respiratory failure: method. Recommendations / O.T. Prasmytsky, R.E. Rzheutskaya. Minsk: BSMU, 2008 .-- 68 p.

4. Method of wave biomechanotherapy. United States Patent 7094210 B2. Date of Patent: August 22, 2006.

5. Method of wave biomechanotherapy B.S. Saveliev. Invention patent RU 2202323, C2 IPC A61H 9/00, publ. 2003.04.20.

6. Nazarov V.T. Biomechanical stimulation: reality and hope. - Minsk: Polymya, 1986 .-- 95 p.

7.A.S. USSR No. 1797494, class. А63В 23/00. A method of training muscles according to the method of Savelyev B.S. / B.S. Savelier ,. Bulletin No. 7, 1993.

8. Agashin F.K. Biomechanics of percussion movements. - M .: Physical culture and sport, 1977 .-- 207 p.

9. Beloyartsev FF, Perfluorinated carbons in biology and medicine, Sat: Pushchino, 1980, p. 5-21.

Claims (2)

1. A method for the treatment of acute pulmonary insufficiency, which consists in the fact that the most intact lung is preliminarily isolated by artificial ventilation of it with an air-oxygen mixture, and an oxygenated solution of perfluorane is introduced into the second lung through an endotracheal tube equipped with obturating cuffs, followed by replacement of perftorane with an air mixture, and after removal of perfluorane from the lung, artificial ventilation is carried out with an air-oxygen mixture, characterized in that it additionally carries out wave biomechanotherapy of the muscles of the lower leg and chest in the biomechanical resonance mode, in which the modes of action on the spine and respiratory muscles of the chest are synchronized with the phases of breathing , at the same time, through the endotracheal tube using a liquid breathing mixture supply unit, a mixture of oxygenated perfluorane solution with drugs is supplied to the second lung by pulses in the form of a solitary wave with the frequency of the biomechanical spectrum, moreover, this mixture is served while inhaling under a pressure of 8 ÷ 30 mm Hg. and during exhalation under pressure minus 8 ÷ 30 mm Hg. until the partial pressure of oxygen in the blood is at least 80 mm Hg, while the removal of perfluorane from the lungs after the cessation of the supply of liquid breathing mixture is carried out with the patient in the prone position, on the right and left side, causing a cough reflex and synchronously with it, carrying out biomechanical stimulation of the respiratory muscles of the chest, and after the removal of anesthesia, wave biomechanotherapy of the muscles of the chest is performed. 2. A device for implementing the method of treating acute pulmonary insufficiency according to claim 1, comprising a ventilator, a liquid breathing mixture supply unit, an endotracheal tube equipped with obturating cuffs, characterized in that it additionally contains units for wave biomechanotherapy of the leg and chest muscles, a unit biomechanical stimulation of the respiratory muscles of the chest, the obturating cuffs are made vibrating, and the obturating cuffs of the endotracheal tube and all units operate at biomechanical resonance frequencies.

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