RU2741209C1 - Cerebral cortex stimulation system for recovery of short-term and long-term memory in post-stroke period - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to medical equipment. System effects the receptor systems of the body: eyes using RGB-LEDs installed in the mask, on auditory receptors with the help of stereo headphones and magnetic field exposure locally to cerebral cortex by means of thirty-two emitters of magnetic effects fixed in helmet on patient's head. Device allows stimulating cerebral neuronal fields by setting the frequency difference on all radiators which are multiples of or close to brain rhythms (alpha, beta, delta, theta, rhythms), as well as colour combinations with supply of different colours to each eye and various frequency modulations of the influencing signal of the magnetic field.

EFFECT: these types of action on the cerebral cortex and hippocampus in the frequency range from 0.1 Hz to 700 Hz enable to stimulate short-term memory and stimulate long-term memory for rehabilitation of the patient in the poststroke period.

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Description

The proposed technical solution relates to the field of health, namely to restorative (rehabilitation) medicine, to the means of stimulating the structures of the neurons of the cerebral cortex and hippocampus in the post-stroke period. The task of the proposed system for stimulating the cerebral cortex to restore short-term and long-term memory in the post-stroke period is volumetric stimulation of the electrical activity of the neurons of the brain and hippocampus through the receptor systems - visual and auditory, as well as through the action of a magnetic field on the cerebral cortex, the parameters of which are close to the rhythms of electrical activity of the brain alpha, beta, theta, delta rhythms.

Of the modern approaches used in medical technical systems for the rehabilitation of people who have suffered a stroke, physiotherapy, computerized and robotic kinesiotherapy systems, training in virtual reality, electromyographic-biological feedback, functional electrical stimulation and transcranial magnetic stimulation can be distinguished. (Ibragimov, M.F., Khabirov, F.A., Khaibullin, T.I., Granatov, E.V. Modern approaches to the rehabilitation of patients with stroke // Practical medicine. - 2012. - No. 57.) [one]

Of the existing magnetic stimulation systems, the closest to the claimed technical solution are: Neuro MS / D, MagPro, Tamas, Magstim Rapid, a device for combined transcranial physiotherapy - application 2009117359/14, 05/06/2009, a device for transcranial exposure to a rotating magnetic field - application 2010129708 / 14, 15.07.2010, these devices have a number of disadvantages.

The Neuro MS / D, MagPro, Tamas, Magstim Rapid line of devices has technical drawbacks:

1) Insufficient number of influencing emitters, which does not allow to cover the entire cerebral cortex by stimulating effects of a magnetic field;

2) Limited variability of the influencing magnetic field from the point of view of changing the switching frequencies of the impact;

3) A large amplitude of the acting magnetic field from 1.5 T to 4 T, which causes motor reactions of the induced magnetic field on receptor neurons and does not affect the general functioning of neural fields, therefore this device cannot be used in the treatment and rehabilitation of patients with lesions of the cerebral cortex efficiently;

4) Lack of the possibility of audio-visual influences, with the difference in the frequencies of the effects equal to the different rhythms of the brain.

For devices for combined transcranial physiotherapy - application 2009117359/14, 05/06/2009, installation for transcranial exposure with a rotating magnetic field - application 2010129708/14, 07/15/2010 technical disadvantages are:

1) A small number of influencing emitters, which does not provide an accurate effect at the local level, and also does not allow stimulating many zones of a small area at the same time;

2) Insufficient amount of variation in characteristics of the influencing magnetic field;

3) The inability to regulate the characteristics of algorithms for exposure to the magnetic field of each emitter separately;

4) Lack of the possibility of audio-visual influences, with the difference in the frequencies of the effects equal to the different rhythms of the brain.

Of the existing devices for audio-visual stimulation, the closest to the declared technical solution are: Nova Pro 100, Inner Pulse, Luma 10, Pro Tutor - www.photosonix.com; Application 2002131036/14, 18.11.2002 and Lingvostim Sensory Stimulation Device - www.lingvostim.com; application: 2013111778/14, 03/15/2013. These devices have several disadvantages.

The line of devices Nova Pro 100, Inner Pulse, Luma 10, Pro Tutor and devices for sensory stimulation "lingua" technical disadvantages are:

1) The inability to regulate the forms of influencing signals;

2) Lack of installation of various options for frequency modulation of influencing signals;

3) The inability to configure and control the impact on each eye with a separate signal and influencing frequency;

4) The inability to form the characteristics of the impact with a different color and frequency for each eye.

The task of this technical solution is to create an effective technical system for the restoration of short-term and long-term memory in the post-stroke period.

The solution to the problem of volumetric stimulation of the electrical activity of neurons in the cerebral cortex and hippocampus is achieved by the simultaneous application of the sum of influences: on the receptor systems (visual and auditory) and a low-intensity effect of a magnetic field on the neural fields of the brain. At the same time, the parameters of these influences and their electrical characteristics, determined by pre-measured encephalograms, are close to the parameters of alpha, beta, theta, delta rhythms of electrical activity of groups of brain neurons, which causes electrical resonance of induced signals on the axons of neurons, which have electrical signals of interneuronal connections. Through the receptor systems (eyes and ears) and through magnetic fields with the guidance of electrical signals in the neurons of the cerebral cortex and in the hippocampus, in this case, stimulation of neurons increases the activity of healthy (unaffected) neurons, which determine the work of the brain to fix reliable signals during the formation of elements memory, including short-term memory. Methodically, this is achieved by placing light emitters in glasses in front of each of the eyes, the location of sound emitters (audio signals) in each ear and magnetic emitters on the surface of the head in the amount of thirty-two pieces and the formation of the necessary influences determined by the block for forming the characteristics of magnetic influences. The difference in the frequencies of light and audio influences (sound range) applied to each of the eyes and to each of the ears are equal to or close to the frequencies of the rhythms of the electrical activity of the brain of a particular patient. Similarly, the difference in the number of switchings of switching on the emitters of magnetic fields is programmatically determined to be equal to or close to the alpha, beta, theta, delta rhythms of a particular patient measured before using this system, which makes it possible to increase the area and depth of stimulation of healthy neural fields of the patient's brain, which can restore piecewise »Fragments of memory, especially long-term memory, since, as studies carried out by various authors have shown, long-term memory is distributed throughout the cerebral cortex. [2]

By the term "short-term memory" we mean the period during which information is stored mainly in the structures of the hippocampus. The term "long-term memory" in this work means the final stage of the process of consolidation of the memory trace in the neocortex. Accordingly, "short-term" memory implies reversibility and possible leveling of the recorded data, while the registration of information in the "long-term" memory system is characterized by stability and irreversibility. [3]

After the primary processing of information about an object / event in the neocortex analyzers with the formation of its internal representation and the isolation of significant features, the information is directed to the structures of the parahippocampal and peririnal cortex [4, 5, 6]. The peririnal cortex analyzes the “nonspatial” features (what?) Of the object, while the parahippocampal cortex analyzes the spatial (where?) Information [4]. It has been shown that the parahippocampal structures of the cerebral cortex evaluate the novelty of information [4]. From the structures of the parahippocampal and peririnal cortex, processed information is transmitted to the medial and lateral parts of the entorhinal cortex, respectively [4, 5, 6]. The exact functions of the entorhial cortex remain unclear, but it is known that all information from the neocortex enters the hippocampus only through this structure.

The transition from short-term memory to long-term memory is called consolidation. In the process of consolidation, data accumulates, as well as their integration and association with other data in memory of this type, which provides a faster search for the required data. The basis of long-term memory is the engram. An engram is a kind of "imprint" of memory, which is formed as a result of activity. It is a combination of physical, chemical and morphological changes in nervous structures that have a significant impact on the reflex reactions of the body.

The hippocampus receives information processed in the parahippocampal region through the structures of the entorhinal cortex. Information from the medial (spatial) and lateral (object-identifying) parts of the entorhinal cortex enters the same neural networks in the dentate gyrus and CA3 region of the hippocampus, but is projected into different neural networks in the CA1 and subiculum regions [4]. Such a neuromorphological organization of entorhinal-hippocampal connections ensures the association of events and contexts in some structures and their separate processing in other structures of the hippocampus. In general, the most important characteristic of the functioning of the memory system of mammals and, possibly, other animals is obligate registration of events and objects in combination with a visual-spatial context, i.e. at the initial stage, any information is registered as "episodic" [4]. It is known that the hippocampus forms the initial engram, but the mechanisms of this process continue to be actively studied. The hippocampus is a temporary storage of information patterns, and this function is realized due to the extremely high plasticity of the hippocampal cortex and its ability to “erase” and update the recorded data [7, 8]. Information in the hippocampus is stored unstructured and can be easily altered by interfering influences. Thus, the most important function of the hippocampus is the transfer of a significant information pattern to the structures of the cerebral cortex capable of reliable and long-term storage of structured knowledge. It is assumed that the transmission and consolidation of information in the corresponding zones of the neocortex is carried out by structures in the posterior parts of the hippocampus [9]. The transmission of information to the long-term memory of the neocortex is ensured by repeated “replays” by the hippocampus of significant information patterns with the integration of the relevant zones of the neocortex into a common neocortex [10, 11]. Repeated "playing" of information patterns by the hippocampus with concomitant activation of neocortex structures occur both in the waking state and in sleep [10, 12]. In humans, the functions of the hippocampus are lateralized; the left hippocampus is predominantly involved in memorizing verbal information, and the right hippocampus is non-verbal [13]. It is assumed that age-related changes in the volume of the hippocampal cortex are associated with a decrease in neurogenesis in this brain structure. [3]

Today, there are various hypotheses about the biochemical mechanisms of long-term memory. [14]

Of these, two main ones can be distinguished - these are synaptic and genomic.

The reason for the high popularity of the synaptic memory hypothesis is rooted in the main paradigm of modern neurophysiology. According to this paradigm, all functions of the nervous system are carried out exclusively at the level of neural networks. In this case, the neurons that form the networks are considered as simple elements, the function of which is reduced to generating electrical potentials and transmitting signals to other neurons. This concept applies equally to both the simpler functions of the nervous system (involuntary reflexes, control of breathing, locomotion and other rhythmic movements, maintaining homeostasis, etc.), carried out mainly by spinal-stem mechanisms, and to higher, mental functions of the human brain, carried by the large hemispheres. As noted in previous publications [16, 17], this concept actually reduces the brain to the level of a gigantic learning computer built of binary elements with two discrete states - “0” (rest) and “1” (excitation of the “ all or nothing").

According to the genomic hypothesis, long-term memory is mainly stored at the intracellular level in the form of genome modifications (in the broadest sense of the word, which includes epigenetic modifications). In other words, this hypothesis assumes that neurons of the corresponding parts of the brain are carriers of elementary traces of memory and that memories of various facts and events are the result of complex cooperative activity of such neurons. In this sense, the genomic hypothesis in no way denies, but expands on the synaptic memory hypothesis. [fifteen]

H. Hyden's hypothesis. According to his experiments, the formation of memory traces occurs along with changes in the properties of RNA and proteins in neurons. Different structure of impulse potentials in neurons causes different rearrangements of RNA molecules, specific for each signal of nucleotide movement in the chain. As a result, each signal is recorded as a specific imprint in the RNA structure. This, in turn, leads to the synthesis of a specific protein, which ensures the selective sensitivity of neurons to certain influences. [18-21]

The hypothesis of transferring memory D. Ungar. In the 1970s, D. Ungar suggested that certain proteins are involved in the storage of memory engrams. [22-26]

Lynch and Baudry hypothesis. The concentration of calcium ions around the postsynaptic membrane increases after repeated stimulation of neurons. As a result, calcium-dependent proteinase - calpein - is activated in the membrane of the postsynaptic neuron. Calpein, breaks down the structural protein - fodrin. As a result, glutamate-sensitive receptors, which were previously blocked, are activated. With an increase in the number of active glutamate receptors, the conductivity of the neuron synapse increases. [27-29]

The assumption about the connection of EEG rhythms with memory processes fits into the general outline of ideas about the morphological and functional foundations of memory. According to the hypothesis of Donald Hebb, the repeated passage of electrical activity through closed circuits of neurons (reverberation) is a physiological mechanism for the preservation of a trace (engram) in short-term memory and a necessary condition for the transition of this trace into long-term memory. Continuing for a certain time, the reverberation leads to consolidation - morphofunctional and biochemical changes in the synapses of the neural ensemble [30]. When it is necessary to extract information from long-term memory, the latent engram is updated only when the "molecular code" is translated back to the level of electrical activity. Access to information stored in long-term memory is carried out by a certain supposed control system, which, in order to ensure the search for information through all memory neural networks, must be connected to the cortex by numerous axonal connections. The basal ganglia and the thalamus, which is associated with virtually all areas of the cortex, have such properties [31]. It is known that the EEG alpha rhythm is generated in thalamo-cortical neural networks [32; 33], and its amplitude correlates with the intensity of the hemodynamic signal in the thalamus [34; 35]. Given these facts, one can come to an assumption about the relationship between alpha and long-term memory.

Theta-rhythm of the EEG reflects the activity of the cortical-limbic neural networks [36; 37]. Many authors associate the processes of contextual coding of information with the activity of the limbic system and, above all, with the hippocampus, i.e. integration of relevant polymodal information to store new episodes in memory [38; 39]. If the hippocampus is actually involved in coding the context, then one would expect that there are numerous two-way connections of the hippocampus with the associative areas of the cortex. Such connections are well known [40]. It is also known that in the process of processing new information, only a small percentage of hippocampal-cortical feedback loops are synchronized [41]. This may mean that theta activity occurs selectively only in certain areas of the cortex, in which new information is encoded or recent information is retrieved from memory. Finally, it was shown that it is in the hippocampus that long-term potentiation occurs and that theta activity induces or at least enhances it [42]. Long-term potentiation represents a long-term increase in the efficiency of synaptic transmission and acts in the theory of synaptic plasticity as the basis of learning and memory mechanisms. The fact that long-term potentiation is regarded as the most important electrophysiological correlate of the process of coding new information underlines the possible importance of hippocampal theta for episodic memory processes. Theta rhythm is also considered as a necessary component of the control system serving the processes of working memory. [43.44]

Physiological and therapeutic effects of the magnetic field (MF) are due to the following physical phenomena - the Hall effect (magnetoelectric) and the Lorentz effect (magnetomechanical).

The Hall effect is that in moving conductors crossing the lines of force of the MF, an electrical potential difference arises, and if the moving conductor is a closed loop, an electric current arises in it. A constant magnetic field (PMF) induces a difference in electrical potentials and short-circuited eddy currents or Foucault currents in moving body fluids (blood, lymph, tissue fluid, cell cytoplasm), which are based on electrolytes (Na + and Cl- ions), which are electrical conductors. An alternating magnetic field (AMF) and a pulsed magnetic field (PMF) induce a difference in electrical potentials and short-circuited eddy currents not only in moving, but also in resting tissue fluids, which may be one of the main reasons for the more intense biological and therapeutic effect of these forms of MF on compared with PMP. The biological and therapeutic effect of induction microcurrents is based on the change in the state of cell membranes and enzymatic and receptor molecules associated with the membranes, an increase in the permeability of the plasmolemma of cells, caused by them. Under the action of high-intensity pulsed MFs with a magnetic induction of more than 0.8 T, currents are induced in the conductive media of the body, the strength of which exceeds the excitation threshold of the nervous and muscular structures, resulting in an avalanche-like depolarization of nerves and muscles, muscle contractions.

The Lorentz effect (magnetomechanical) is that mechanical forces of attraction and repulsion act between two sources of MF. The modality of the magnetomechanical interaction (the direction of the Lorentz force) depends on the direction of the lines of force (polarity) of the MF. If the magnetic field lines of the fields of two MF sources have opposite directions, then mechanical repulsive forces arise between them. If the magnetic field lines of the fields of two MF sources have the same (parallel) direction, then mechanical forces of attraction arise between them.

The Lorenz effect explains many of the biological and healing effects of MF. The specific activity of some intracellular enzymes and membrane receptors that mediate the action of hormones and mediators changes. This is due to the presence of an uncompensated magnetic moment in the molecules included in the active center of these biologically active macromolecules. As a result of external magnetic influence in atoms with unpaired valence electrons, a shift of electron clouds occurs, which leads to a change in the conformation of the active center of the enzyme or receptor. The sensitivity of receptors to ligands (hormones, mediators) changes, the nature of the interaction of the enzyme with the substrate changes, resulting in an acceleration or slowdown of intracellular biochemical reactions. [45]

A more detailed mechanism of the effect of a magnetic field on the cerebral cortex at the cellular level is described in the following sources. [46-53]

It is rather difficult to obtain an accurate visualization of the effect of a magnetic field on the cerebral cortex: methods of electrical recording in the brain or spinal cord are invasive and are mainly used for studies on animals, artifacts arising from exposure to a magnetic field make it difficult to record during and immediately after an exposure pulse. uncertainty about the foci of stimulation, as well as experimental approaches, do not yet allow assessing the neural response in terms of depth, position and types of cells [54-56]. Optical imaging techniques such as two-photon calcium imaging [57,58] can overcome some of these limitations, including magnetic field artifacts and cell type identification, although the action potential of induced calcium transients may be too long (> 100 ms ) to distinguish direct from indirect activation of cells [59]. However, these methods have not yet been used in the study of TMS in humans and non-human primates. [60]

Visual stimulation is a method in which a change in the functional state of the central nervous system is achieved through exposure to periodic pulses of light (flash) on the visual analyzer (eyes). The frequencies of the signals acting on both eyes can be either the same or with a certain frequency difference, which must correspond to the rhythm of the brain.

Color stimulation is a method in which a change in the functional state of the central nervous system is achieved through exposure to combinations of color compositions (red, blue and green). The colors exposed to the eyes can be the same or different.

Audio stimulation using binaural beats is a method of influencing auditory analyzers (ears) with frequencies that differ from each other in a certain range not exceeding 30 Hz. The frequencies of the acting signals to both ears can be either the same or with a certain frequency difference, which must correspond to the rhythm of the brain.

In this system, we combine the effect of MF on the cerebral cortex with magnetic field values up to 1-5 mT, together with audio-visual stimulation (ABC) on the human receptor system. We believe that there is no need to influence large magnetic fields with a magnitude of up to 2.2 T. And quite enough values of the order of 1-5 mT with the use of various frequency modulations of the signal, types of impulses.

As a result of the combined effect, neurons of the cerebral cortex and hippocampus are stimulated, which are responsible for the functioning of short-term and long-term memory, which leads to the restoration of the patient's memory in the post-stroke period.

Taking into account the above hypotheses, the technical result is a created system for stimulating the cerebral cortex to restore short-term and long-term memory in the post-stroke period, which is capable of forming the characteristics of the acting audio-video signals and magnetic fields separately applied to the right and left eyes, right and left ear , and on magnetic emitters in certain combinations that allow you to effectively influence the neural fields of the brain, which will significantly increase the area of stimulation of the cerebral cortex and hippocampus due to the use of 32 magnetic emitters covering the entire cerebral cortex, as well as expand the field of application in medicine specifically for recovery short-term and long-term memory in the post-stroke period. The authors carried out experiments on healthy volunteers, which confirms the effectiveness of this system. [61]

A functional diagram of a system for stimulating the cerebral cortex to restore short-term and long-term memory in the post-stroke period is shown in Fig. 1. Which includes a control unit and software audio-light-color-magnetic effects, which includes a block of programs for light and color effects of influences, a block of programs for audio effects, a block of programs for magnetic effects; blocks of formation of characteristics of light and color effects, blocks of formation of characteristics of audio effects, blocks of formation of characteristics of magnetic effects, the parameters of which are determined by the control unit; speakers located in stereo headphones, RGB-LEDs located in glasses, 32 solenoids-emitters fixed in the helmet.

The arrangement of the magnetic field emitters of the magnetic action unit is shown in Fig. 2.

The design of the system for stimulating the cerebral cortex to restore short-term and long-term memory in the post-stroke period is shown in FIG. 3. The system for stimulating the cerebral cortex to restore short-term and long-term memory in the post-stroke period includes an audio action unit 35, a light action unit 34, a helmet with mounts for emitters 33 and a generation and control unit 36.

The magnetic impact unit consists of a helmet with mounts for emitters 33 and thirty-two magnetic emitters 1-32.

The system works as follows. An action algorithm is selected on the control unit, which sets: the operating mode, characteristics of the influencing signals and the exposure time of each of them. After setting all the parameters, the "Start" button is pressed. Further, the programmed formation of the exposed influences in the formation unit, where the conversion takes place through the emitters into an audio signal. Similarly formed characteristics are fed to rgb-LEDs, which convert the impact into a light and color signal. A similarly generated signal is fed to the emitting coil. All impacts or each of them ends after the expiration of time.

Algorithms of exposure to stimulate neural fields and the hippocampus to restore short-term memory:

1. We use 6 magnetic emitters indicated in the figure under the numbers 15,16,25,27,28,30; the frequency of exposure corresponds to 4 to 8 Hz (theta rhythm), we set the exposure period to 10 minutes. We set the type of impulse: sinusoid, rectangular, triangular and sawtooth. The location of the emitters is above the hippocampus (six emitters above the ears numbered 15,16,25,27,28,30).

Impact type Emitter / Color Audio- The signal frequency is 440 Hz, the frequency difference between the emitters is equal to theta rhythm, the exposure time is 6-8 minutes, the type of pulse: sinusoid, rectangular. Light- • The frequency on both emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular.
• The frequency difference on the emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular. Color- • Red, blue, green, purple and their combinations. Sequential inclusion of the same color combinations on both eyes at the same time.
• Red, blue, green, purple and their combinations. Sequential inclusion of different color combinations for both eyes. Magnetic Emitters with numbers 15,16,25,27,28,30 (see figure 2).

2. We use 6 magnetic emitters indicated in the figure under the numbers 15,16,25,27,28,30; used initial exposure frequency 4 Hz, exposure periods of 6 minutes followed by a frequency shift of 1 Hz at an initial frequency of 4 Hz. The total number of shift periods is 5. Set the type of impulse: sine, rectangular, triangular and sawtooth. The location of the emitters is above the hippocampus (six emitters above the ears numbered 15,16,25,27,28,30).

Impact type Emitter / Color Audio- The signal frequency is 440 Hz, the frequency difference between the emitters is equal to theta rhythm, the exposure time is 6-8 minutes, the type of pulse: sinusoid, rectangular. Light- • The frequency on both emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular.
• The frequency difference on the emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular. Color- • Red, blue, green, purple and their combinations. Sequential inclusion of the same color combinations on both eyes at the same time.
• Red, blue, green, purple and their combinations. Sequential inclusion of different color combinations for both eyes. Magnetic Emitters with numbers 15,16,25,27,28,30 (see figure 2).

3. We use 6 magnetic emitters indicated in the figure under the numbers 15,16,25,27,28,30; we use frequency modulation, the frequency deviation of the modulated signal is from 4 to 8 Hz, we set Fmin = 4 Hz, Fmax = 8 Hz, the modulating signal corresponds to 4 to 8 Hz (theta rhythm), the exposure period is 10 minutes. We set the type of pulse of the modulated signal: sinusoid, rectangular, triangular and sawtooth. We set the type of pulse of the modulating signal: sinusoid, rectangular, triangular and sawtooth. The location of the emitters is above the hippocampus (six emitters above the ears numbered 15,16,25,27,28,30).

Impact type Emitter / Color Audio- The signal frequency is 440 Hz, the frequency difference between the emitters is equal to theta rhythm, the exposure time is 6-8 minutes, the type of pulse: sinusoid, rectangular. Light- • The frequency on both emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular.
• The frequency difference on the emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular. Color- • Red, blue, green, purple and their combinations. Sequential inclusion of the same color combinations on both eyes at the same time.
• Red, blue, green, purple and their combinations. Sequential inclusion of different color combinations for both eyes. Magnetic Emitters with numbers 15,16,25,27,28,30 (see figure 2).

4. We use 6 magnetic emitters indicated in the figure under the numbers 15,16,25,27,28,30; we use frequency modulation, the frequency deviation of the modulated signal is from 0 to 700 Hz, we set Fmin = 0 Hz, Fmax = 700 Hz, the modulating signal corresponds to 4 Hz, then after each exposure period it increases by 1 Hz, the exposure period is 6 minutes, the total number of shift periods equals 5. Set the type of pulse of the modulated signal: sinusoid, rectangular, triangular and sawtooth. We set the type of pulse of the modulating signal: sinusoid, rectangular, triangular and sawtooth. The location of the emitters is above the hippocampus (six emitters above the ears numbered 15,16,25,27,28,30).

Impact type Emitter / Color Audio- The signal frequency is 440 Hz, the frequency difference between the emitters is equal to theta rhythm, the exposure time is 6-8 minutes, the type of pulse: sinusoid, rectangular. Light- • The frequency on both emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular.
• The frequency difference on the emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular. Color- • Red, blue, green, purple and their combinations. Sequential inclusion of the same color combinations on both eyes at the same time.
• Red, blue, green, purple and their combinations. Sequential inclusion of different color combinations for both eyes. Magnetic Emitters with numbers 15,16,25,27,28,30 (see figure 2).

Algorithms for stimulating neural fields to restore long-term memory:

5. We activate all magnetic emitters, we use frequency modulation, the frequency deviation of the modulated signal is from 4 to 8 Hz, we set Fmin = 4 Hz, Fmax = 8 Hz, the modulating signal corresponds to 4 to 8 Hz (theta rhythm), the exposure period is 10 minutes. We set the type of pulse of the modulated signal: sinusoid, rectangular, triangular and sawtooth. We set the type of pulse of the modulating signal: sinusoid, rectangular, triangular and sawtooth.

Impact type Emitter / Color Audio- The signal frequency is 440 Hz, the frequency difference between the emitters is equal to theta rhythm, the exposure time is 6-8 minutes, the type of pulse: sinusoid, rectangular. Light- • The frequency on both emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular.
• The frequency difference on the emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular. Color- • Red, blue, green, purple and their combinations. Sequential inclusion of the same color combinations on both eyes at the same time.
• Red, blue, green, purple and their combinations. Sequential inclusion of different color combinations for both eyes. Magnetic All magnetic emitters (see figure 2).

6. We activate all magnetic emitters, we use frequency modulation, the frequency deviation of the modulated signal is from 4 to 8 Hz, we set Fmin = 4 Hz, Fmax = 8 Hz, the modulating signal corresponds to 4 Hz, then after each exposure period it increases by 1 Hz, the exposure period 6 minutes, the total number of shift periods is 5. Set the type of pulse of the modulated signal: sinusoid, rectangular, triangular and sawtooth. We set the type of pulse of the modulating signal: sinusoid, rectangular, triangular and sawtooth.

Impact type Emitter / Color Audio- The signal frequency is 440 Hz, the frequency difference between the emitters is equal to theta rhythm, the exposure time is 6-8 minutes, the type of pulse: sinusoid, rectangular. Light- • The frequency on both emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular.
• The frequency difference on the emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular. Color- • Red, blue, green, purple and their combinations. Sequential inclusion of the same color combinations on both eyes at the same time.
• Red, blue, green, purple and their combinations. Sequential inclusion of different color combinations for both eyes. Magnetic All magnetic emitters (see figure 2).

7. We activate all magnetic emitters, we use frequency modulation, the frequency deviation of the modulated signal is from 0 to 200 Hz, we set Fmin = 0 Hz, Fmax = 200 Hz, the modulating signal corresponds to 4 to 8 Hz (theta rhythm), the exposure period is 10 minutes. We set the type of pulse of the modulated signal: sinusoid, rectangular, triangular and sawtooth. We set the type of pulse of the modulating signal: sinusoid, rectangular, triangular and sawtooth.

Impact type Emitter / Color Audio- The signal frequency is 440 Hz, the frequency difference between the emitters is equal to theta rhythm, the exposure time is 6-8 minutes, the type of pulse: sinusoid, rectangular. Light- • The frequency on both emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular.
• The frequency difference on the emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular. Color- • Red, blue, green, purple and their combinations. Sequential inclusion of the same color combinations on both eyes at the same time.
• Red, blue, green, purple and their combinations. Sequential inclusion of different color combinations for both eyes. Magnetic All magnetic emitters (see figure 2).

8. We activate all magnetic emitters, we use frequency modulation, the frequency deviation of the modulated signal is from 0 to 200 Hz, we set Fmin = 0 Hz, Fmax = 200 Hz, the modulating signal corresponds to 4 Hz, then after each period of exposure it increases by 1 Hz, the period of exposure 6 minutes, the total number of shift periods is 5. Set the type of pulse of the modulated signal: sinusoid, rectangular, triangular and sawtooth. We set the type of pulse of the modulating signal: sinusoid, rectangular, triangular and sawtooth.

Impact type Emitter / Color Audio- The signal frequency is 440 Hz, the frequency difference between the emitters is equal to theta rhythm, the exposure time is 6-8 minutes, the type of pulse: sinusoid, rectangular. Light- • The frequency on both emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular.
• The frequency difference on the emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular. Color- • Red, blue, green, purple and their combinations. Sequential inclusion of the same color combinations on both eyes at the same time.
• Red, blue, green, purple and their combinations. Sequential inclusion of different color combinations for both eyes. Magnetic All magnetic emitters (see figure 2).

9. We activate all magnetic emitters, we use frequency modulation, the frequency deviation of the modulated signal is from 0 to 700 Hz, we set Fmin = 0 Hz, Fmax = 700 Hz, the modulating signal corresponds to 4 to 8 Hz (theta rhythm), the exposure period is 10 minutes. We set the type of pulse of the modulated signal: sinusoid, rectangular, triangular and sawtooth. We set the type of pulse of the modulating signal: sinusoid, rectangular, triangular and sawtooth.

Impact type Emitter / Color Audio- The signal frequency is 440 Hz, the frequency difference between the emitters is equal to theta rhythm, the exposure time is 6-8 minutes, the type of pulse: sinusoid, rectangular. Light- • The frequency on both emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular.
• The frequency difference on the emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular. Color- • Red, blue, green, purple and their combinations. Sequential inclusion of the same color combinations on both eyes at the same time.
• Red, blue, green, purple and their combinations. Sequential inclusion of different color combinations for both eyes. Magnetic All magnetic emitters (see figure 2).

10. We activate all magnetic emitters, we use frequency modulation, the frequency deviation of the modulated signal is from 0 to 700 Hz, we set Fmin = 0 Hz, Fmax = 700 Hz, the modulating signal corresponds to 4 Hz, then after each exposure period it increases by 1 Hz, the exposure period 6 minutes, the total number of shift periods is 5. Set the type of pulse of the modulated signal: sinusoid, rectangular, triangular and sawtooth. We set the type of pulse of the modulating signal: sinusoid, rectangular, triangular and sawtooth.

Impact type Emitter / Color Audio- The signal frequency is 440 Hz, the frequency difference between the emitters is equal to theta rhythm, the exposure time is 6-8 minutes, the type of pulse: sinusoid, rectangular. Light- • The frequency on both emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular.
• The frequency difference on the emitters corresponds to the theta rhythm, the exposure time is 6-8 minutes. Pulse type: sine wave, rectangular. Color- • Red, blue, green, purple and their combinations. Sequential inclusion of the same color combinations on both eyes at the same time.
• Red, blue, green, purple and their combinations. Sequential inclusion of different color combinations for both eyes. Magnetic All magnetic emitters (see figure 2).

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Claims (3)

1. The system of stimulation of the cerebral cortex for the restoration of short-term and long-term memory in the post-stroke period includes a control unit and a program audio-light-color-magneto effect, consisting of a block of audio-light-color-magnetism programs, a block of programs of light and color effects, a block of programs of magnetic influence, formation of characteristics of audio, light, color and magnetic influences, emitters of audio effects, made with the possibility of fixing on each ear, emitters of light and color effects, made with the possibility of fixing on each eye, thirty-two emitters of magnetic influences, fixed in the helmet on the head the patient. 2. The system according to claim 1, characterized in that the emitters of audio effects are made in the form of stereo headphones. 3. The system according to claim 1, characterized in that the emitters of light and color effects are made in the form of glasses.

Images