RU2717078C1 - Method for obtaining nanocapsules of dry plantain extract - Google Patents

Abstract

FIELD: nanotechnologies.

SUBSTANCE: invention relates to the field of nanotechnology, medicine, cosmetic and food industry. Method of producing nano capsules of a plantain extract is characterized by that a plantain yeast extract is added to a kappa-carrageenan suspension in isoheptane in presence of 0.01 g glycerol ester with one or two food fatty acid molecules and one or two molecules of citric acid as surfactant while stirring 700 rpm, acetonitrile is then poured, the resulting nanocapsule suspension is filtered and dried at room temperature, with the core:shell mass ratio being 1:1, 1:2 or 1:3.

EFFECT: method for obtaining nanocapsules of dry plantain extract has been proposed.

1 cl, 3 ex

Description

The invention relates to the field of nanotechnology, medicine, pharmacology, cosmetic and food industries.

Previously known methods for producing microcapsules.

In US Pat. 2173140 IPC A61K 009/50, A61K 009/127 Russian Federation published September 10, 2001. A method for producing silicon organolipid microcapsules using a rotary-cavitation unit with high shear forces and powerful sonar and ultrasonic sonar acoustic dispersion ranges is proposed.

The disadvantage of this method is the use of special equipment - a rotary cavitation unit, which has an ultrasonic effect, which affects the formation of microcapsules and can cause adverse reactions due to the fact that ultrasound destructively affects polymers of a protein nature, therefore, the proposed method is applicable when work with polymers of synthetic origin

In US Pat. 2359662 IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 published 06/27/2009 The Russian Federation proposed a method of producing microcapsules of sodium chloride using spray cooling in a Niro spray cooling tower under the following conditions: inlet air temperature 10 ° C, outlet air temperature 28 ° C, the rotation speed of the spray drum 10,000 rpm. The microcapsules of the invention have improved stability and provide controlled and / or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, a set of certain conditions (air temperature at the inlet 10 ° C, air temperature at the outlet 28 ° C, rotation speed of the spray drum 10,000 rpm).

The closest method is the method proposed in US Pat. 2134967 IPC A01N 53/00, A01N 25/28 published on 08.27.1999 Russian Federation (1999). A solution of a mixture of natural lipids and a pyrethroid insecticide in a weight ratio of 2-4: 1 in an organic solvent is dispersed in water, which simplifies the microencapsulation method.

The disadvantage of this method is dispersion in an aqueous medium, which makes the proposed method inapplicable for producing microcapsules of water-soluble preparations in water-soluble polymers.

The technical task is to simplify and accelerate the process of obtaining nanocapsules, reducing losses in obtaining nanocapsules (increase in yield by mass).

The solution to the technical problem is achieved by the method of producing nanocapsules, characterized in that kappa-carrageenan is used as the shell of the nanocapsules, and plantain dry extract is used as the core when nanocapsules are prepared by non-solvent precipitation using acetonitrile as a precipitant.

A distinctive feature of the proposed method is the preparation of nanocapsules by non-solvent precipitation using acetonitrile as a precipitant, as well as the use of kappa-carrageenan as a particle shell and dry plantain extract as a core.

The result of the proposed method are obtaining nanocapsules of dry plantain extract.

EXAMPLE 1. Obtaining nanocapsules of dry plantain extract, the ratio of core: shell 1: 3

1 g of dry plantain extract is added to a suspension of 3 g of kappa-carrageenan in isoheptane in the presence of 0.01 g of the preparation E472 s (glycerol ester with one or two molecules of food fatty acids and one or two molecules of citric acid, with citric acid as a tribasic , can be esterified with other glycerides and as an acid with other fatty acids. Free acid groups can be neutralized with sodium) as a surfactant with stirring at 700 rpm. Then poured 7 ml of acetonitrile. The resulting suspension was filtered and dried at room temperature.

Received 4 g of nanocapsule powder. The yield was 100%.

EXAMPLE 2. Obtaining nanocapsules of dry plantain extract, the ratio of core: shell 1: 1

1 g of dry plantain extract is added to a suspension of 1 g of kappa-carrageenan in isoheptane in the presence of 0.01 g of the preparation E472 c as a surfactant with stirring at 700 rpm. Then poured 7 ml of acetonitrile. The resulting suspension was filtered and dried at room temperature.

Received 2 g of nanocapsule powder. The yield was 100%.

Example 3. Obtaining nanocapsules of dry plantain extract, the ratio of the core: bog 1: 2

1 g of dry plantain extract is added to a suspension of 2 g of kappa-carrageenan in isoheptane in the presence of 0.01 g of E472 c as a surfactant with stirring at 700 rpm. Then poured 7 ml of acetonitrile. The resulting suspension was filtered and dried at room temperature.

Received 3 g of nanocapsule powder. The yield was 100%.

Claims (1)

A method of producing nanocapsules of dry plantain extract, characterized in that the plantain dry extract is added to a suspension of kappa-carrageenan in isoheptane in the presence of 0.01 g of glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid as a surface the active substance with stirring at 700 rpm, then pour acetonitrile, the resulting suspension of nanocapsules is filtered off and dried at room temperature, while the mass ratio of the core: shell is 1: 1, 1: 2 or 1: 3.