RU2714440C2 - Method of anaesthesia in dentistry - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to dentistry, and can be used for pain relief in dentistry. That is ensured by single intravenous bolus introduction of one of non-steroidal anti-inflammatory compounds - ketorolac tromethamine in dose of 15–75 mg, or sodium metamizole in dose of 500–2500 mg, or ketoprofen in dose of 50–250 mg, or dexketoprofen in dose of 25–125 mg, or lornoxicam in dose of 4–20 mg - in a period of time from the moment ranging from 3 hours to 15 seconds before the beginning of anaesthesia and proper dental intervention before the beginning of the predicted time of beginning the resolution of local intraoperative anaesthesia, determined by selecting a specific preparation of local anaesthetics.

EFFECT: method provides complete absence of pain syndrome in the operated region developing immediately after the dental intervention and local postoperative anaesthesia termination within the first postoperative day.

1 cl, 2 tbl, 50 ex

Description

The invention relates to medicine, namely to dentistry, and can be used to prevent a pain syndrome that develops in patients in the operated area immediately after undergoing dental interventions, accompanied by trauma to the tissues of the dentofacial sphere or oral cavity, manifesting after the end of local intraoperative anesthesia.

A known analogue method of analgesia in dentistry during surgical interventions on the jaw, information source: Bunyatyan A.A. Guide to anesthesiology / A.A. Bunyatyan - Moscow: “Medicine”, 1994. - § 22.1., Paragraph 1. - P. 368. The known method in the analogue is as follows. After premedication with atropine, diazepam and promedol in generally accepted doses, a Burchet block of the chewing nerve and large chewing muscle is performed to facilitate opening of the mouth. The needle is inserted at a point 2 cm anterior to the tragus of the ear under the zygomatic arch. 3-5 ml of a 2% solution of trimecaine or a 2% solution of lidocaine is injected to a depth of 2-2.5 cm, and an additional 1-2 ml is injected when the needle is removed. After 5-10 minutes it is usually possible to open the mouth and perform intraoral blockade of the mandibular nerve. Infiltration anesthesia of the incision site in the submandibular region is also used. After the onset of the effect of conduction anesthesia, ketamine is administered intravenously at a dose of 1.5-2 mg / kg and an intervention is performed. Throughout the procedure, insufflation with a mixture of oxygen and nitrous oxide in a ratio of 40-60% through a nasal mask or catheter is carried out.

Disadvantages:

1. the presence of pain in the operated area, developing immediately after the completion of the dental intervention and the end of the operation of intraoperative anesthesia, and existing for a long time as part of the first day from the end of the dental intervention and the end of the operation of intraoperative anesthesia;

2. high complexity, namely multi-stage, technical complexity - the need for complex skills and the use of additional equipment, namely oxygen, anesthesia, artificial lung ventilation equipment, airway devices, a multicomponent set of medications.

The closest known method (prototype) of anesthesia in dentistry using local anesthesia is known, information source: LS Persin Pediatric Dentistry / Persin L.S., Elizarova V.M., Dyakov S.V. - Moscow: Medicine, 2006 .-- S. 118-121. The known method in the prototype is as follows. A solution of a local anesthetic is injected, namely, novocaine, trimecaine, lidocaine, trimecaine, mepivacaine, articaine, prilocaine, bupivacaine or analogues in soft tissues in the area of the causative tooth or other anatomical object of dental intervention. After exposure from a few seconds to several minutes, a state of local anesthesia develops in the operated area, which allows for dental intervention in the absence of pain in it. Depending on the features of the method, there are its application, infiltration and conductor options.

Disadvantages: the presence of pain in the operated area, which develops immediately after a dental intervention and the end of local intraoperative anesthesia, and exists for a long time as part of the first day from the end of the dental intervention and the end of intraoperative anesthesia. So, after performing a dental intervention and the term of local anesthesia, which is approximately 30-180 minutes, in patients in the area of dental intervention, accompanied by trauma to the tissues of the dentofacial sphere or oral cavity, a priori significant pain develops over the next 3- 20 hours

In order to eliminate the identified shortcomings, the authors proposed the inventive method having a high technical result.

Technical result: the absence of the development of a pain syndrome in the operated area immediately after a dental intervention and the end of the operation of intraoperative anesthesia, achieved with the low complexity of the method.

The technical result in the method of pain relief in dentistry is achieved by using a single intravenous bolus injection of one of the following drugs of non-steroidal anti-inflammatory compounds (hereinafter NSAIDs) - ketorolac tromethamine at a dose of 15-75 mg, or metamizole sodium at a dose of 500-2500 mg, or ketoprofen a dose of 50-250 mg, or dexketoprofen at a dose of 25-125 mg, or lornoxicam at a dose of 4-20 mg - in a period of time from the moment of 3 hours to 15 seconds before starting anesthesia and the actual dental intervention Until the start of the predicted start time for resolving local intraoperative anesthesia, determined by the choice of a specific preparation of local anesthetics.

Since alternative essential features are included in the independent claim, use a single intravenous bolus injection of one of the following preparations of non-steroidal anti-inflammatory compounds (NSAIDs) - ketorolac tromethamine at a dose of 15-75 mg, or metamizole sodium at a dose of 500-2500 mg, or Ketoprofen at a dose of 50-250 mg, or dexketoprofen at a dose of 25-125 mg, or lornoxicam at a dose of 4-20 mg, we explain the possibility of obtaining a technical result with various combinations of characteristics of these characteristics in. These signs with this alternative, in combination with other signs included in the claims, provide the same technical result - the absence of a pain syndrome in the operated area that develops when using the analogous methods immediately after a dental intervention and the end of local intraoperative anesthesia, and existing for a long time in the first day from the date of completion of dental interventions and the end of the action of intraoperative local anesthesia, achieved with the low complexity of the method.

The above NSAIDs - ketorolac tromethamine, metamizole sodium, ketoprofen, dexketoprofen, lornoxicam used in the present method are pharmacologically equivalent, because have similar pharmacokinetic characteristics and an identical mechanism of action. This allows you to use different representatives of the same pharmacological group, depending on the need - various production situations, availability on sale, different costs, varying costs.

The absence of a pain syndrome, which in traditional conditions develops after a dental intervention from the moment local anesthesia is completed, is achieved by the use of a single intravenous bolus injection of one of the following NSAIDs - ketorolac tromethamine at a dose of 15-75 mg, or metamizole sodium at a dose of 500- 2500 mg, or ketoprofen at a dose of 50-250 mg, or dexketoprofen at a dose of 25-125 mg, or lornoxicam at a dose of 4-20 mg - in a period of time from the moment of 3 hours to 15 seconds before starting Ia anesthesia and proper dental treatment before the start of the projected start time permits intraoperative local anesthesia, determines the choice of a particular drug of local anesthetics.

The use of NSAIDs inhibits the synthesis and release of prostaglandins from damaged tissues - pro-inflammatory mediators, which are the main tissue algogens. This prevents them from both primary and secondary sensitization of nociceptive structures of the peripheral nervous system, has a direct anti-inflammatory and analgesic effect, and also potentiates the analgesic effect of local anesthetics. The possibility of using ketorolac tromethamine at a dose of 15-75 mg, or metamizole sodium at a dose of 500-2500 mg, or ketoprofen at a dose of 50-250 mg, or dexketoprofen at a dose of 25-125 mg, or lornoxicam at a dose of 4-20 mg is explained by that these drugs have similar pharmacokinetic characteristics, homological similarity, and an identical mechanism of action.

A single administration of NSAIDs in the claimed method is sufficient to deliver their optimal dose, provide the necessary concentration in the target cells and, accordingly, the necessary intensity and duration of the anti-inflammatory / analgesic effect. Intravenous administration provides 100% bioavailability of the drugs used, their rapid accumulation and, accordingly, the early onset and the proper level of intensity of their pharmacological action. A bolus injection, in contrast to a drip infusion, allows for the rapid implementation of the method, which ensures the absence of a significant increase in the time required for the provision of dental benefits.

The introduction of NSAIDs precisely in the period from the time of 3 hours to 15 seconds before the start of anesthesia and the actual dental intervention to the start of the predicted time to start resolving local intraoperative anesthesia, determined by the choice of a particular preparation of local anesthetics, allows the multimodal and preventive analgesia and, thereby, achieve the desired level of effectiveness of the method.

It should be clarified that the moment of the start of the resolution of local anesthesia should be considered the time that occurred after the introduction of the local anesthetic, at which the patient states that the initial signs of tissue sensitivity appeared in the injection zone (in other words, we can talk about the transition of anesthesia to hyposthesia). For articaine hydrochloride - a local anesthetic used in dentistry at present in the vast majority of cases (including in the present method), the time of onset of this moment after administration is 60-180 minutes. In turn, the termination of local anesthesia resolution traditionally means the complete restoration of the state of tissue sensitivity, which it was before the administration of the anesthetic (before anesthesia); in this case, there are no signs of anesthesia, its effect is virtually absent, the sensitivity in the operated area (injection zone) is fully restored.

The format of multimodal analgesia is realized by the fact that in the indicated period of administration of the claimed drugs the analgesic effect of NSAIDs that are part of the proposed method enters into drug synergism with the analgesic effect of local anesthetics, which are an essential component of almost any dental tool. The format of preventive analgesia is realized by the fact that the administration of the declared analgesic drugs from the pharmacological group of NSAIDs is carried out before the appearance of a pain syndrome manifesting against the background of a decrease in the effect of intraoperatively introduced local anesthetics.

The introduction of the claimed drugs no earlier than 3 hours before the start of local anesthesia and the actual dental intervention is explained by the fact that the minimum half-life (T _0.5 ) for the claimed NSAIDs does not exceed 3 hours. So, for ketorolac tromethamine, it is 2 , 4 hours, for metamizole sodium - 2 hours, for ketoprofen - 2 hours, for dexketoprofen - 1 hour, for lornoxicam - 3 hours. This means that if these drugs are administered earlier than 3 hours before local anesthesia and the actual dental interventions to At the time of intraoperative trauma of dental and paradental tissues, most of the administered dose of the drug is excreted from the target cells, which leads to a significant decrease in the proactive analgesic effect.

The introduction of the claimed drugs no later than 15 seconds before the start of local anesthesia and the actual dental intervention is due to the limitation of the maximum intravenous rate of the claimed NSAIDs at exactly 15 seconds by official manufacturing companies.

The introduction of the claimed drugs before the start of the predicted start time for the resolution of local intraoperative anesthesia, determined by the choice of a specific preparation of local anesthetics, is explained by the fact that when they are administered after the action of local anesthesia is resolved, there is no prevention of the development of pain, as in this situation, it already exists de facto. At the same time, the predicted start time for resolving local anesthesia is determined by the dentist choosing the specific preparation of local anesthetics. For example, for novocaine it will be 0.5-1 hours, for lidocaine - 1.5-1.5 hours, for articaine - 1-3 hours, etc.

The low complexity of the method is achieved by the fact that it is one-stage and technically simple - there is no need to use complex skills and additional equipment, namely oxygen, anesthesia, artificial lung ventilation equipment, airway patency devices, and also a multicomponent set of medicines. Moreover, for the implementation of the method requires only one active pharmacological drug.

In the present method, in contrast to analogues, a single intravenous bolus injection of one of the following NSAIDs is used - ketorolac tromethamine at a dose of 15-75 mg, or metamizole sodium at a dose of 500-2500 mg, or ketoprofen at a dose of 50-250 mg, or dexketoprofen in a dose of 25-125 mg, or lornoxicam in a dose of 4-20 mg - in the period from the moment of 3 hours to 15 seconds before the start of anesthesia and the actual dental intervention until the start of the predicted time for the resolution of local intraoperative Nesthesia, determined by the choice of a specific preparation of local anesthetics.

The use of the proposed method ensures the complete absence of pain in the operated area after the interventions with the low complexity of the application of the proposed method.

The inventive method does not have side effects, subject to the implementation technique, which consists in a single intravenous bolus injection of one of the following NSAIDs, namely ketorolac tromethamine at a dose of 15-75 mg, or metamizole sodium at a dose of 500-2500 mg, or ketoprofen at a dose of 50 -250 mg, or dexketoprofen at a dose of 25-125 mg, or lornoxicam at a dose of 4-20 mg. The minimum administration time is 15 seconds, the maximum administration time is variable and does not matter.

A comparative analysis of the proposed method with the prototype allows us to conclude that the claimed invention meets the conditions of patentability: it is new, has an inventive step and is industrially applicable.

Information on the use in dentistry of a single intravenous bolus injection of one of the following NSAIDs - ketorolac tromethamine at a dose of 15-75 mg, or metamizole sodium at a dose of 500-2500 mg, or ketoprofen at a dose of 50-250 mg, or dexketoprofen at a dose of 25-125 mg, or lornoxicam in a dose of 4-20 mg - in the period from the time from 3 hours to 15 seconds before the start of anesthesia and the actual dental intervention until the start of the predicted time to start resolving local intraoperative anesthesia, predelyaemogo choice of a particular drug of local anesthetics in the available literature and other information sources found.

The inventive method is as follows.

Before starting the dental manual, a single intravenous bolus is administered in one of the following NSAIDs, namely ketorolac tromethamine at a dose of 15-75 mg, or metamizole sodium at a dose of 500-2500 mg, or ketoprofen at a dose of 50-250 mg, or dexketoprofen at a dose of 25 -125 mg, or lornoxicam in a dose of 4-20 mg - during the period from the moment of 3 hours to 15 seconds before the start of anesthesia and the actual dental intervention until the start of the predicted time for the resolution of local intraoperation constant anesthesia, determines the choice of a particular drug of local anesthetics.

The rate of administration is variable (but not faster than 15 seconds) and is not critical. As a result, a complete absence of pain in the operated area after undergoing dental interventions is achieved.

The application of the method leads to the achievement of the actual absence of pain after dental surgery, accompanied by trauma to the tissues of the dentofacial sphere or oral cavity (the possible level of pain is from 0 to 2 points on the Visual analogue scale (VAS) and Digital rating scale (TsRS), which equates to the actual absence of pain).

The minimum doses of NSAIDs claimed for use in the method are 15 mg for ketorolac tromethamine, 500 mg for metamizole, 50 mg for ketoprofen, 25 mg for dexketoprofen, and 4 mg for lornoxicam, because their smaller doses are ineffective.

The maximum doses of NSAIDs claimed for use in the method are 75 mg for ketorolac tromethamine, 2500 mg for metamizole sodium, 250 mg for ketoprofen, 125 mg for dexketoprofen, and 20 mg for lornoxicam, because their large doses are associated with a risk of developing overdose effects (nausea, vomiting, dizziness, poor health).

The optimal doses of NSAIDs claimed for use in the method are: for ketorolac tromethamine - 30 mg, for metamizole sodium - 1000 mg, for ketoprofen - 100 mg, for dexketoprofen - 50 mg, for lornoxicam - 8 mg, because they provide the optimal level of analgesic effect for the statistical majority of patients.

The minimum injection time is 15 seconds, because this is the minimum time required by the companies manufacturing NSAID drugs that are approved for intravenous administration.

The maximum time of administration is variable and does not matter.

The method provides a complete warning of the development of pain in the operated area after dental interventions due to intravenous administration of NSAIDs in certain doses at one of the specific time stages of the dental manual.

The proposed method is illustrated by examples of specific performance.

1. Examples using ketorolac tromethamine.

Example 1. Patient S., age 20 years, diagnosis: deep tooth decay 3.5 .; operation: preparation of the carious cavity; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 05.05.2014. Prevention of postoperative pain was performed by the claimed method: ketorolac tromethamine 30 mg intravenously 3 hours before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 2. Patient M., age 25 years old, diagnosis: pulpitis of the tooth 3.5 .; operation: pulp extraction; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 05/06/2014. Prevention of postoperative pain was performed by the claimed method: ketorolac tromethamine 45 mg intravenously 2 hours before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 3. Patient B., age 30 years, diagnosis: pulpitis of the tooth 3.6 .; operation: pulp extraction; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of the official solution of anesthetic); research date: 05/07/2014. Prevention of postoperative pain was performed by the claimed method: ketorolac tromethamine 15 mg intravenously 1 hour before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 4. Patient E., age 36 years old, diagnosis: periodontitis of the tooth 3.2 .; operation: preparation of root canals; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); study date: 05/08/2014. Prevention of postoperative pain was performed by the claimed method: ketorolac tromethamine 15 mg intravenously 30 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 5. Patient A., age 41 years old, diagnosis: deep tooth decay 1.1 .; operation: preparation of the carious cavity; intraoperative anesthesia: local infiltration (articaine hydrochloride 68 mg + adrenaline hydrochloride 0.006 mg in 1.7 ml of an official solution of anesthetic); research date: 05/09/2014. Prevention of postoperative pain was performed by the claimed method: ketorolac tromethamine 45 mg intravenously 20 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 6. Patient P., age 47 years old, diagnosis: pulpitis of the tooth 2.1 .; operation: cavity preparation, pulp extraction; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 05/13/2014. Prevention of postoperative pain was performed by the claimed method: ketorolac tromethamine 30 mg intravenously 10 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 7. Patient M., age 50 years old, diagnosis: deep tooth decay 4.8 .; operation: cavity preparation, pulp extraction; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 136 mg + adrenaline hydrochloride 0.02 mg in 3.4 ml of an official solution of anesthetic); research date: 05/14/2014. Prevention of postoperative pain was performed by the claimed method: ketorolac tromethamine 30 mg intravenously 5 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 1 points for CRS, which means the actual absence of pain).

Example 8. Patient S., age 54 years old, diagnosis: chronic fibrous pulpitis of the tooth 1.1 .; operation: tooth extraction 1.1 .; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 05/15/2014. Prevention of postoperative pain was performed by the claimed method: ketorolac tromethamine 15 mg intravenously 1 minute before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 9. Patient D., age 32 years old, diagnosis: chronic fibrous pulpitis of the tooth 4.8 .; operation: tooth extraction 4.8 .; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 05.16.2014. Prevention of postoperative pain was performed by the claimed method: ketorolac tromethamine 15 mg intravenously 30 seconds before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 10. Patient E., age 28 years old, diagnosis: dystopia, tooth retention 3.8 .; operation: tooth extraction 3.8 .; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.15 mg in the composition of 2.55 ml of the official solution of anesthetic); research date: 05/19/2014. Prevention of postoperative pain was performed by the claimed method: ketorolac tromethamine 30 mg intravenously 15 seconds before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 11. Patient A., age 41 years old, diagnosis: deep tooth decay 1.1 .; operation: preparation of the carious cavity; intraoperative anesthesia: local infiltration (articaine hydrochloride 68 mg + adrenaline hydrochloride 0.006 mg in 1.7 ml of an official solution of anesthetic); study date: 05/09/2014. Prevention of postoperative pain was performed by the claimed method: ketorolac tromethamine 15 mg intravenously 3 hours before local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the absence of a clinically significant pain syndrome was detected (maximum level - 2 points for YOUR, 2 points for central nervous system, which means the actual absence of pain).

2. Examples using metamizole sodium.

Example 1. Patient B., age 24 years old, diagnosis: deep tooth decay 3.5 .; operation: preparation of the carious cavity; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 05/20/2014. Prevention of postoperative pain was performed by the claimed method: metamizole sodium 1000 mg intravenously 3 hours before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 2. Patient M., age 21 years old, diagnosis: pulpitis of the tooth Z.5 .; operation: pulp extraction; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 05/21/2014. Prevention of postoperative pain was performed by the claimed method: metamizole sodium 1500 mg intravenously 2 hours before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 3. Patient A., age 37 years old, diagnosis: pulpitis of the tooth 3.6 .; operation: pulp extraction; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of the official solution of anesthetic); study date: 05/22/2014. Prevention of postoperative pain was performed by the claimed method: metamizole sodium 500 mg intravenously 1 hour before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 4. Patient S., age 30 years old, diagnosis: periodontitis of the tooth 3.2 .; operation: preparation of root canals; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 05/23/2014. Prevention of postoperative pain was performed by the claimed method: metamizole sodium 500 mg intravenously 30 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 5. Patient S., age 40 years old, diagnosis: deep tooth decay 1.1 .; operation: preparation of the carious cavity; intraoperative anesthesia: local infiltration (articaine hydrochloride 68 mg + adrenaline hydrochloride 0.006 mg in 1.7 ml of an official solution of anesthetic); research date: 05/26/2014. Prevention of postoperative pain was performed by the claimed method: metamizole sodium 1000 mg intravenously 20 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 6. Patient D., age 48 years old, diagnosis: pulpitis of the tooth 2.1 .; operation: cavity preparation, pulp extraction; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 05/27/2014. Prevention of postoperative pain was performed by the claimed method: metamizole sodium 1000 mg intravenously 10 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 7. Patient E., age 51 years old, diagnosis: deep tooth decay 4.8 .; operation: cavity preparation, pulp extraction; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 136 mg + adrenaline hydrochloride 0.02 mg in 3.4 ml of an official solution of anesthetic); research date: 05/28/2014. Prevention of postoperative pain was performed by the claimed method: metamizole sodium 1500 mg intravenously 5 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 1 points for CRS, which means the actual absence of pain).

Example 8. Patient A., age 49 years old, diagnosis: chronic fibrous pulpitis of the tooth 1.1 .; operation: tooth extraction 1.1 .; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 05/29/2014. Prevention of postoperative pain was performed by the claimed method: metamizole sodium 1000 mg intravenously 1 minute before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 9. Patient B., age 31 years old, diagnosis: chronic fibrous pulpitis of the tooth 4.8 .; operation: tooth extraction 4.8 .; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 05/30/2014. Prevention of postoperative pain was performed by the claimed method: metamizole sodium 500 mg intravenously 30 seconds before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 10. Patient M., age 37 years old, diagnosis: dystopia, tooth retention 3.8 .; operation: tooth extraction 3.8 .; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.15 mg in the composition of 2.55 ml of the official solution of anesthetic); study date: 06/02/2014. Prevention of postoperative pain was performed by the claimed method: metamizole sodium 1000 mg intravenously 15 seconds before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

3. Examples using ketoprofen.

Example 1. Patient M .., age 21 years old, diagnosis: deep tooth decay 3.5 .; operation: preparation of the carious cavity; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 06/03/2014. Prevention of postoperative pain was performed by the claimed method: ketoprofen 100 mg intravenously 3 hours before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 2. Patient M., age 23 years, diagnosis: pulpitis of the tooth 3.5 .; operation: pulp extraction; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 06/04/2014. Prevention of postoperative pain was performed by the claimed method: ketoprofen 150 mg intravenously 2 hours before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 3. Patient B., age 39 years old, diagnosis: pulpitis of the tooth 3.6 .; operation: pulp extraction; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of the official solution of anesthetic); research date: 05.06.2014. Prevention of postoperative pain was performed by the claimed method: ketoprofen 50 mg intravenously 1 hour before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 4. Patient A., age 35 years old, diagnosis: periodontitis of the tooth 3.2 .; operation: preparation of root canals; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 06.06.2014. Prevention of postoperative pain was performed by the claimed method: ketoprofen 50 mg intravenously 30 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 5. Patient E., age 43 years old, diagnosis: deep tooth decay 1.1 .; operation: preparation of the carious cavity; intraoperative anesthesia: local infiltration (articaine hydrochloride 68 mg + adrenaline hydrochloride 0.006 mg in 1.7 ml of an official solution of anesthetic); research date: 06/09/2014. Prevention of postoperative pain was performed by the claimed method: ketoprofen 100 mg intravenously 20 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 6. Patient A., age 49 years old, diagnosis: pulpitis of the tooth 2.1 .; operation: cavity preparation, pulp extraction; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 06/10/2014. Prevention of postoperative pain was performed by the claimed method: ketoprofen 150 mg intravenously 10 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 7. Patient B., age 54 years, diagnosis: deep tooth decay 4.8 .; operation: cavity preparation, pulp extraction; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 136 mg + adrenaline hydrochloride 0.02 mg in 3.4 ml of an official solution of anesthetic); research date: 06/11/2014. Prevention of postoperative pain was performed by the claimed method: ketoprofen 100 mg intravenously 5 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 1 points for CRS, which means the actual absence of pain).

Example 8. Patient G., age 47 years old, diagnosis: chronic fibrous pulpitis of the tooth 1.1 .; operation: tooth extraction 1.1 .; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 06/12/2014. Prevention of postoperative pain was performed by the claimed method: ketoprofen 50 mg intravenously 1 minute before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 9. Patient I., age 33 years old, diagnosis: chronic fibrous pulpitis of the tooth 4.8 .; operation: tooth extraction 4.8 .; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); study date: 06/16/2014. Prevention of postoperative pain was performed by the claimed method: ketoprofen 100 mg intravenously 30 seconds before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 10. Patient K., age 25 years old, diagnosis: dystopia, tooth retention 3.8 .; operation: tooth extraction 3.8 .; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.15 mg in the composition of 2.55 ml of the official solution of anesthetic); research date: June 16, 2014. Prevention of postoperative pain was performed by the claimed method: ketoprofen 50 mg intravenously 15 seconds before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

4. Examples using dexketoprofen.

Example 1. Patient M., age 23 years, diagnosis: deep tooth decay 3.5 .; operation: preparation of the carious cavity; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 06/17/2014. Prevention of postoperative pain was performed by the claimed method: dexketoprofen 50 mg intravenously 3 hours before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 2. Patient K., age 20 years, diagnosis: pulpitis of the tooth 3.5 .; operation: pulp extraction; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 06/18/2014 Prevention of postoperative pain was performed by the claimed method: dexketoprofen 75 mg intravenously 2 hours before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 3. Patient A., age 37 years old, diagnosis: pulpitis of the tooth 3.6 .; operation: pulp extraction; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of the official solution of anesthetic); research date: 06/19/2014. Prevention of postoperative pain was performed by the claimed method: dexketoprofen 25 mg intravenously 1 hour before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 4. Patient S., age 32 years, diagnosis: periodontitis of the tooth 3.2 .; operation: preparation of root canals; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 06/20/2014. Prevention of postoperative pain was performed by the claimed method: dexketoprofen 25 mg intravenously 30 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 5. Patient B., age 40 years old, diagnosis: deep tooth decay 1.1 .; operation: preparation of the carious cavity; intraoperative anesthesia: local infiltration (articaine hydrochloride 68 mg + adrenaline hydrochloride 0.006 mg in 1.7 ml of an official solution of anesthetic); research date: 06/23/2014. Prevention of postoperative pain was performed by the claimed method: dexketoprofen 50 mg intravenously 20 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 6. Patient E., age 46 years old, diagnosis: pulpitis of the tooth 2.1 .; operation: cavity preparation, pulp extraction; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 06/24/2014 Prevention of postoperative pain was performed by the claimed method: dexketoprofen 75 mg intravenously 10 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 7. Patient D., age 52 years old, diagnosis: deep tooth decay 4.8 .; operation: cavity preparation, pulp extraction; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 136 mg + adrenaline hydrochloride 0.02 mg in 3.4 ml of an official solution of anesthetic); research date: 06/25/2014. Prevention of postoperative pain was performed by the claimed method: dexketoprofen 25 mg intravenously 5 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 1 points for CRS, which means the actual absence of pain).

Example 8. Patient M., age 55 years old, diagnosis: chronic fibrous pulpitis of the tooth 1.1 .; operation: tooth extraction 1.1 .; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 06/26/2014. Prevention of postoperative pain was performed by the claimed method: dexketoprofen 25 mg intravenously 1 minute before starting local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 9. Patient A., age 30 years old, diagnosis: chronic fibrous pulpitis of the tooth 4.8 .; operation: tooth extraction 4.8 .; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 06/27/2014. Prevention of postoperative pain was performed by the claimed method: dexketoprofen 50 mg intravenously 30 seconds before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 10. Patient E., age 29 years old, diagnosis: dystopia, tooth retention 3.8 .; operation: tooth extraction 3.8 .; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.15 mg in the composition of 2.55 ml of the official solution of anesthetic); research date: 06/30/2014. Prevention of postoperative pain was performed by the claimed method: dexketoprofen 50 mg intravenously 15 seconds before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

5. Examples using lornoxicam.

Example 1. Patient K., age 22 years old, diagnosis: deep tooth decay 3.5 .; operation: preparation of the carious cavity; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 07/01/2014. Prevention of postoperative pain was performed by the claimed method: 8 mg of lornoxicam intravenously 3 hours before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 2. Patient O., age 24 years old, diagnosis: pulpitis of the tooth 3.5 .; operation: pulp extraction; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 07/02/2014. Prevention of postoperative pain was performed by the claimed method: lornoxicam 12 mg intravenously 2 hours before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 3. Patient B., age 32 years, diagnosis: pulpitis of the tooth 3.6 .; operation: pulp extraction; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of the official solution of anesthetic); study date: 07/03/2014. Prevention of postoperative pain was performed by the claimed method: 4 mg of lornoxicam intravenously 1 hour before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 4. Patient E., age 34 years old, diagnosis: periodontitis of the tooth 3.2 .; operation: preparation of root canals; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 07/04/2014. Prevention of postoperative pain was performed by the claimed method: 4 mg of lornoxicam intravenously 30 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 5. Patient N., age 42 years, diagnosis: deep tooth decay 1.1 .; operation: preparation of the carious cavity; intraoperative anesthesia: local infiltration (articaine hydrochloride 68 mg + adrenaline hydrochloride 0.006 mg in 1.7 ml of an official solution of anesthetic); study date: 07/07/2014. Prevention of postoperative pain was performed by the claimed method: lornoxicam 8 mg intravenously 20 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 6. Patient I., age 47 years old, diagnosis: pulpitis of the tooth 2.1 .; operation: cavity preparation, pulp extraction; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 07/08/2014. Prevention of postoperative pain was performed by the claimed method: lornoxicam 12 mg intravenously 10 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 0 points for central nervous system, which means the actual absence of pain).

Example 7. Patient K., age 50 years old, diagnosis: deep tooth decay 4.8 .; operation: cavity preparation, pulp extraction; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 136 mg + adrenaline hydrochloride 0.02 mg in 3.4 ml of an official solution of anesthetic); research date: 07/09/2014. Prevention of postoperative pain was performed by the claimed method: 8 mg of lornoxicam intravenously 5 minutes before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain was observed (maximum level - 0 points for YOUR, 1 points for CRS, which means the actual absence of pain).

Example 8. Patient I., age 53 years old, diagnosis: chronic fibrous pulpitis of the tooth 1.1 .; operation: tooth extraction 1.1 .; intraoperative anesthesia: local infiltration (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 07/10/2014. Prevention of postoperative pain was performed by the claimed method: 4 mg of lornoxicam intravenously 1 minute before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 9. Patient Y., age 32 years old, diagnosis: chronic fibrous pulpitis of the tooth 4.8 .; operation: tooth extraction 4.8 .; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.015 mg in the composition of 2.55 ml of an official solution of anesthetic); research date: 07/11/2014. Prevention of postoperative pain was performed by the claimed method: 4 mg of lornoxicam intravenously 30 seconds before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

Example 10. Patient B., age 27 years old, diagnosis: dystopia, retention of the tooth 3.8 .; operation: tooth extraction 3.8 .; intraoperative anesthesia: local conductor mandibular (articaine hydrochloride 102 mg + adrenaline hydrochloride 0.15 mg in the composition of 2.55 ml of the official solution of anesthetic); research date: 07/14/2014. Prevention of postoperative pain was performed by the claimed method: 8 mg of lornoxicam intravenously 15 seconds before the start of local anesthesia and the actual dental intervention. When observing the patient within 24 hours after the end of the dental intervention, the complete absence of postoperative pain syndrome was observed (maximum level - 1 point according to YOUR, 1 point according to the central nervous system, which means the actual absence of pain).

The method was applied in 100 patients with indications for dental interventions. A total of 200 patients were examined with indications for dental interventions (of which 100 patients with the claimed and 100 patients with the known method, respectively). The studies were carried out during the first days from the moment of completion of the dental intervention. The results obtained are statistically significant and are presented in tables 1 and 2.

Thus, from the data given in table 1, it follows that preventing the development of postoperative pain syndrome during dental interventions in the vast majority of cases is possible using the proposed method (at the level of 91%), but not possible using the known method.

The data of table 2 show that when using the proposed method, the flow rates of postoperative pain syndrome are statistically significant and fundamentally different from those using the known method. So, when using the proposed method, the following data are obvious: in the vast majority of cases, there is no postoperative pain syndrome; in the same minimum number of cases in which it does develop, its level is not clinically significant (the maximum intensity is 2 points with a threshold (unacceptable) value of 4 points). When using the known method, on the contrary, postoperative pain is present in all cases; while its level is always clinically significant, because has invalid values (4 or more points). The level of statistical significance of differences in the indicator of postoperative pain syndrome between the compared methods is more than 99% (since the exact value is p <0.01).

Thus, the claimed method, in contrast to the known, can practically prevent the likelihood of developing postoperative pain syndrome during dental interventions. This does not occur when applying analog methods.

Technical and economic effect.

Using the proposed method will ensure the absence of pain in the operated area that develops immediately after a dental intervention and the end of local intraoperative anesthesia, achieved with a low complexity of the method.

Claims (1)

A method of analgesia in dentistry, characterized in that they use a single intravenous bolus injection of one of the following preparations of non-steroidal anti-inflammatory compounds - ketorolac tromethamine at a dose of 15-75 mg, or metamizole sodium at a dose of 500-2500 mg, or ketoprofen at a dose of 50-250 mg, or dexketoprofen at a dose of 25-125 mg, or lornoxicam at a dose of 4-20 mg - in the period from the moment of 3 hours to 15 seconds before the start of anesthesia and the actual dental intervention until the beginning we predict the time of the beginning of the resolution of local intraoperative anesthesia, determined by the choice of a specific preparation of local anesthetics.